Academic literature on the topic 'Lateralization index'

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Journal articles on the topic "Lateralization index"

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Zou, Hongliang, and Jian Yang. "Exploring the Brain Lateralization in ADHD Based on Variability of Resting-State fMRI Signal." Journal of Attention Disorders 25, no. 2 (December 6, 2018): 258–64. http://dx.doi.org/10.1177/1087054718816170.

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Objective: In this study, we investigate the brain lateralization in ADHD patients. Furthermore, we also explore the difference between male and female patients, and the difference among distinct ADHD subtypes, that is, ADHD–inattentive (ADHD-IA) and ADHD–combined (ADHD-C). Method: We employed the standard deviation to quantify the variability of resting-state functional magnetic resonance imaging (fMRI) signal and measure the lateralization index (LI). Results: ADHD patients showed significantly increased rightward lateralization in the inferior frontal gyrus (opercular), precuneus, and paracentral lobule, and decreased rightward lateralization in the insula. Compared with male patients, female patients showed significantly rightward lateralization in the putamen and lobule VII of cerebellar hemisphere. ADHD-C patients exhibited increased rightward lateralization in the inferior frontal gyrus (opercular), and decreased rightward lateralization in the inferior temporal gyrus, as compared with ADHD-IA. The LI was also found to be related to inattentive and hyper/impulsive scores. Conclusion: These key findings may aid in understanding the pathology of ADHD.
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Yozamp, Nicholas, Gregory L. Hundemer, Marwan Moussa, Jonathan Underhill, Tali Fudim, Barry Sacks, and Anand Vaidya. "Adrenocorticotropic Hormone–Stimulated Adrenal Venous Sampling Underestimates Surgically Curable Primary Aldosteronism: A Retrospective Cohort Study and Review of Contemporary Studies." Hypertension 78, no. 1 (July 2021): 94–103. http://dx.doi.org/10.1161/hypertensionaha.121.17248.

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Guidelines recommend adrenal venous sampling to determine disease laterality in primary aldosteronism. Adrenocorticotropic hormone (ACTH) stimulation clearly improves the likelihood of successful adrenal vein catheterization but may lead to a decrease in lateralization rates. To examine the impact of ACTH on lateralization, we performed a retrospective analysis of 340 patients with confirmed primary aldosteronism who underwent adrenal venous sampling with a single interventional radiology team using a protocol of sampling both before and after an ACTH bolus. In addition to this original research, we conducted a review of similar studies from the past 5 years to develop a consensus on the impact of ACTH on lateralization for primary aldosteronism. In the original research analysis, following a bolus of ACTH, 58% of patients had a decline in lateralization index which led to discordance between the pre-ACTH and post-ACTH classifications of lateralization in up to 26% of cases. The majority of discordant cases were due to reclassification from unilateral disease pre-ACTH to bilateral disease post-ACTH. In patients who already lateralized with unstimulated sampling, the response to ACTH did not have any impact on surgical outcomes. In a review of contemporary studies, we identified 11 similar studies in the past 5 years, of which 10 reported either no change or a decrease in lateralization index following ACTH, resulting in ≈25% discordance between unstimulated and stimulated lateralization rates. We conclude that ACTH stimulation during adrenal venous sampling can underestimate surgically remediable primary aldosteronism and recommend that the role of ACTH be limited primarily to enhancing selectivity.
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Gazit, Tomer, Fani Andelman, Yifat Glikmann-Johnston, Tal Gonen, Aliya Solski, Irit Shapira-Lichter, Moran Ovadia, et al. "Probabilistic machine learning for the evaluation of presurgical language dominance." Journal of Neurosurgery 125, no. 2 (August 2016): 481–93. http://dx.doi.org/10.3171/2015.7.jns142568.

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OBJECTIVE Providing a reliable assessment of language lateralization is an important task to be performed prior to neurosurgery in patients with epilepsy. Over the last decade, functional MRI (fMRI) has emerged as a useful noninvasive tool for language lateralization, supplementing or replacing traditional invasive methods. In standard practice, fMRI-based language lateralization is assessed qualitatively by visual inspection of fMRI maps at a specific chosen activation threshold. The purpose of this study was to develop and evaluate a new computational technique for providing the probability of each patient to be left, right, or bilateral dominant in language processing. METHODS In 76 patients with epilepsy, a language lateralization index was calculated using the verb-generation fMRI task over a wide range of activation thresholds (from a permissive threshold, analyzing all brain regions, to a harsh threshold, analyzing only the strongest activations). The data were classified using a probabilistic logistic regression method. RESULTS Concordant results between fMRI and Wada lateralization were observed in 89% of patients. Bilateral and right-dominant groups showed similar fMRI lateralization patterns differentiating them from the left-dominant group but still allowing classification in 82% of patients. CONCLUSIONS These findings present the utility of a semi-supervised probabilistic learning approach for presurgical language-dominance mapping, which may be extended to other cognitive domains such as memory and attention.
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O’Toole, Samuel Matthew, Wing-Chiu Candy Sze, Teng-Teng Chung, Scott Alexander Akker, Maralyn Rose Druce, Mona Waterhouse, Sarah Pitkin, et al. "Low-grade Cortisol Cosecretion Has Limited Impact on ACTH-stimulated AVS Parameters in Primary Aldosteronism." Journal of Clinical Endocrinology & Metabolism 105, no. 10 (August 12, 2020): e3776-e3784. http://dx.doi.org/10.1210/clinem/dgaa519.

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Abstract Context In primary aldosteronism, cosecretion of cortisol may alter cortisol-derived adrenal venous sampling indices. Objective To identify whether cortisol cosecretion in primary aldosteronism alters adrenal venous sampling parameters and interpretation. Design Retrospective case–control study Setting A tertiary referral center Patients 144 adult patients with primary aldosteronism who had undergone both adrenocorticotropic hormone-stimulated adrenal venous sampling and dexamethasone suppression testing between 2004 and 2018. Main Outcome Measures Adrenal venous sampling indices including adrenal vein aldosterone/cortisol ratios and the selectivity, lateralization, and contralateral suppression indices. Results 21 (14.6%) patients had evidence of cortisol cosecretion (defined as a failure to suppress cortisol to ≤50 nmol/L post dexamethasone). Patients with evidence of cortisol cosecretion had a higher inferior vena cava cortisol concentration (P = .01) than those without. No difference was observed between the groups in terms of selectivity index, lateralization index, lateralization of aldosterone excess, or adrenal vein cannulation rate. Conclusions Cortisol cosecretion alters some parameters in adrenocorticotrophic hormone-stimulated adrenal venous sampling but does not result in alterations in patient management.
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Dadda, Marco, Wouter H. Koolhaas, and Paolo Domenici. "Behavioural asymmetry affects escape performance in a teleost fish." Biology Letters 6, no. 3 (January 20, 2010): 414–17. http://dx.doi.org/10.1098/rsbl.2009.0904.

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Escape performance is fundamental for survival in fish and most other animals. While previous work has shown that both intrinsic (e.g. size, shape) and extrinsic (e.g. temperature, hypoxia) factors can affect escape performance, the possibility that behavioural asymmetry may affect timing and locomotor performance in startled fish is largely unexplored. Numerous studies have found a relationship between brain lateralization and performance in several cognitive tasks. Here, we tested the hypothesis that behavioural lateralization may affect escape performance in a teleost, the shiner perch Cymatogaster aggregata . Escape responses were elicited by mechanical stimulation and recorded using high-speed video (250 Hz). A number of performance variables were analysed, including directionality, escape latency, turning rate and distance travelled within a fixed time. A lateralization index was obtained by testing the turning preference of each subject in a detour test. While lateralization had no effect on escape directionality, strongly lateralized fish showed higher escape reactivity, i.e. shorter latencies, which were associated with higher turning rates and longer distances travelled. Therefore, lateralization is likely to result in superior ability to escape from predator attacks, since previous work has shown that escape timing, turning rate and distance travelled are among the main determinants of escape success.
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Herbrecht, A., M. Messerer, and F. Parker. "Development of a lateralization index for intramedullary astrocytomas and ependymomas." Neurochirurgie 63, no. 5 (November 2017): 410–12. http://dx.doi.org/10.1016/j.neuchi.2016.04.006.

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WHITEHOUSE, ANDREW J. O., NICHOLAS BADCOCK, MARGRIET A. GROEN, and DOROTHY V. M. BISHOP. "Reliability of a novel paradigm for determining hemispheric lateralization of visuospatial function." Journal of the International Neuropsychological Society 15, no. 6 (November 2009): 1028–32. http://dx.doi.org/10.1017/s1355617709990555.

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AbstractIn most individuals, language production and visuospatial skills are subserved predominantly by the left and right hemispheres, respectively. Functional Transcranial Doppler (fTCD) provides a noninvasive and relatively low-cost method for measuring functional lateralization. However, while the silent word generation task provides an accurate and reliable paradigm for investigating lateralization of language production, there is no comparable gold-standard method for measuring visuospatial skills. Thirty undergraduate students (19 females) completed a task of spatial memory while undergoing fTCD recording. Participants completed this task at two different time points, separated by between 26 to 155 days. The relative activation between hemispheres averaged across all participants was found to be consistent across testing sessions. This was observed at the individual level also, with a quantitative index of lateralization showing high reproducibility. These findings indicate that the use of the spatial memory task with fTCD is a robust methodology for examining laterality of visuospatial skills. (JINS, 2009, 15, 1028–1032.)
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Prabhakar, Anuj, Niranjan Khandelwal, Sameer Vyas, Vivek Gupta, ParampreetS Kharbanda, and Manju Mohanty. "Functional MRI in epilepsy – Comparison of Lateralization index and language scoring." Indian Journal of Radiology and Imaging 29, no. 2 (2019): 168. http://dx.doi.org/10.4103/ijri.ijri_281_18.

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Lim, Dae-Woon, Byung-Chan Min, Hyun-Jun Kim, Mi-Hyun Choi, Soo-Jeong Lee, Jae-Hoon Jun, Bongsoo Lee, and Soon-Cheol Chung. "Cerebral Lateralization Index Based on Intensity of Bold Signal of FMRI." International Journal of Neuroscience 118, no. 11 (January 2008): 1628–42. http://dx.doi.org/10.1080/00207450802330777.

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Liu, Wei, Jingjing Zhang, Yaling Yang, Yinxin Jin, Zaizhao Li, Liting You, Jianguang Luo, and Xin Su. "Effect of Adrenocorticotropic Hormone Stimulation During Simultaneous Bilateral Adrenal Vein Sampling in Primary Aldosteronism." Hormone and Metabolic Research 53, no. 06 (June 2021): 364–70. http://dx.doi.org/10.1055/a-1498-6958.

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AbstractThe aim of the study was to investigate the significance and influence of adrenocorticotropic hormone (ACTH) stimulation in primary aldosteronism (PA) patients with simultaneous bilateral adrenal vein sampling (AVS). All patients diagnosed with PA underwent simultaneous bilateral AVS with ACTH. In 95 patients, the post-ACTH SI significantly increased (p<0.001), and it gradually decreased from t10–t30 after ACTH stimulation (p<0.001). The unsuccessful catheterization decreased after ACTH stimulation. Time points within 20 min after ACTH stimulation were better for sampling, and the selectivity did not increase over longer periods. According to lateralization before and after ACTH stimulation, the patients could be divided into 3 groups (U, unilateral; B, bilateral): U/U , U/B or B/U, and B/B. Compared with the U/U group, in the U/B or B/U and B/B groups, the lateralization index (LI) was lower both at baseline and after ACTH stimulation (p<0.0001), the contralateral index (CLI) was higher after ACTH stimulation (p<0.003), the serum potassium level was higher (p<0.001), and the carbon dioxide combining power (CO2CP) and base excess (BE) levels were lower. In conclusion, in simultaneous bilateral AVS, ACTH stimulation had significant effects on increasing the catheterization selectivity. Lateralization change was observed after stimulation. After ACTH stimulation, fewer patients could be diagnosed with lateralized PA. Patients with consistent lateralized PA showed a more serious phenotype.
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Dissertations / Theses on the topic "Lateralization index"

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Bonnkirch, Nils. "Sprachlateralisierung bei Patienten mit idiopathischem Stottern und bei gesunden Probanden: Ein Vergleich der Ergebnisse funktioneller Magnetresonanztomografie mit denen der Diffusionstensorbildgebung." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0022-5D63-A.

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Die Ursache für das idiopathische Stottern ist bis zum jetzigen Zeitpunkt unbekannt. Typischerweise beginnt die Redeflussstörung im Vorschulalter. Es wird davon ausgegangen, dass 1% der Bevölkerung an Stottern leidet. Bei der Frage nach pathophysiologischen Hintergründen von Sprech- und Sprachstörungen ist der Zusammenhang zwischen einer pathologischen, funktionellen Lateralisierung und einer morphologischen Asymmetrie im Bereich von neuronalen Netzwerken der Sprachbildung bereits seit längerem Gegenstand der Forschung. Im Rahmen der vorliegenden Arbeit wurde die Lateralisierung von Sprache bei 17 stotternden Probanden und 20, im Alter entsprechenden, flüssig sprechenden Probanden untersucht. Hierbei wurde die Sprachlateralisierung mithilfe der fMRT sowohl mit einem Satz- als auch mit einem Wortgenerierungsparadigma ermittelt. Ausgehend von den in der fMRT ermittelten Sprachzentren wurde die angrenzende weiße Substanz unter Verwendung der DTI auf eine Asymmetrie hin untersucht. Im Vergleich zu der Gruppe der Normalprobanden zeigten die schwer stotternden Probanden eine Verschiebung der Indexwerte, deren endgültige Ursache offen bleibt. Gesteigerte funktionelle Aktivierung in Bereichen der rechtshemisphärischen Analoga der Sprachzentren scheint ein möglicher Erklärungsansatz. Vorausgegangene funktionelle Untersuchungen u. a. mittels PET und fMRT bei stotternden Probanden belegten eine Überaktivierung von Teilen des motorischen Kortex sowie eine atypische Lateralisierung bei der Produktion von Sprache mit rechtsseitiger Lateralisierung oder eine bilaterale Aktivität. Darüber hinaus zeigte sich eine morphologische Veränderung, im Sinne einer Abnahme einer linkshemisphärischen Asymmetrie bei den schwer stotternden Probanden, besonders in der an das Wernicke-Areal angrenzenden weißen Substanz. Mithilfe der VBM konnten in mehreren früheren Studien morphologische Unterschiede bei Stotternden gezeigt werden. Gegenüber dem rein morphologischen Untersuchungsansatz vorangegangener Untersuchungen berücksichtigte die Kombination der funktionellen und der diffusionsgewichteten Analyse stärker die intraindividuelle Variabilität der Sprachzentren.
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Book chapters on the topic "Lateralization index"

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"Index." In Cerebral Lateralization in Nonhuman Species, 279–88. Elsevier, 1985. http://dx.doi.org/10.1016/b978-0-12-286480-3.50018-5.

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