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Journal articles on the topic 'Laxative effect'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Wahyuni, Eko Sari, Rudi Hamarno, Taufan Arif, Erlina Suci Astuti, and Rossyana Septiasih. "Effects Of Laxatives On Postoperative Intestinal Sound Recovery." Health Frontiers 2, no. 1 (2024): 1–7. https://doi.org/10.62255/mjhp.v2i1.124.

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Intestinal sound is produced by muscle movements in the digestive tract. The return of intestinal sound after surgery is an important indicator for patients to return to eating and drinking normally. This study aimed to determine whether the administration of laxatives before surgery can speed up the recovery of intestinal sound in patients undergoing surgery with general anesthesia. The study involved 30 patients divided into two groups: a laxative group and a control group. The laxative group received laxatives before surgery, while the control group did not. Intestinal sound recovery time w

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Bruin, Frans de, Karin Hek, Jan van Lieshout, et al. "Laxative co-medication and changes in defecation patterns during opioid use." Journal of Oncology Pharmacy Practice 25, no. 7 (2018): 1613–21. http://dx.doi.org/10.1177/1078155218801066.

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Introduction Opioid-induced constipation is a clinically relevant side effect and a cause of potentially avoidable drug-related hospital admissions. Objectives To describe the presence of laxative co-medication, the reasons for not starting laxatives and to evaluate changes in stool patterns of opioid initiators. Methods In this observational study community pharmacists evaluated the availability of laxative co-medication in starting opioid users and registered reasons for non-use. Two opioid initiators per pharmacy were invited to complete questionnaires (‘Bristol stool form scale’ and ‘Rome

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Hammack, Taylor, Clayton J. Hamilton, and Amber Martinson. "Examining the effect of a Whole Health Primary Care Pain Education and Opioid Monitoring Program (PC-POP) at preventing opioid-induced constipation." Journal of Opioid Management 21, no. 2 (2025): 163–69. https://doi.org/10.5055/jom.0918.

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Objective: The prevention of opioid-induced constipation (OIC) in patients treated for chronic pain is important for an improved quality of life and prevention of complications. This study aims to determine whether the implementation of the Primary Care Pain Education and Opioid Monitoring Program (PC-POP) improved the management of OIC in patients receiving opioids for chronic noncancer pain. Design/measure: Pharmacy records regarding the presence of an appropriate laxative prescription, prescription fills, and laxative types were obtained. The primary outcome was the proportion of patients w

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Kawamata, *Yasushi, Norio Sugawara, Taro Sasaki, et al. "FACTORS ASSOCIATED WITH THE INITIATION OF LAXATIVE USE IN THE SAME PATIENTS WITH SCHIZOPHRENIA OVER A 20-YEAR PERIOD: RETROSPECTIVE COHORT STUDY." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i356—i357. https://doi.org/10.1093/ijnp/pyae059.633.

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Abstract Background Constipation is a common adverse effect of antipsychotics, but little investigation has been conducted. We aimed to address the factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20-year period. Methods We enrolled patients with schizophrenia attending each hospital (n=14) from April 1, 2021, and retrospectively examined all prescriptions as of April 1, 2016, 2011, 2006, and 2001, every 5 years starting in 2021, for this population. 716 participants with complete data were included in the analysis. The Cochran Q test follow

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Freeman, David E., Pamela L. Ferrante, and Jonathan E. Palmer. "Comparison of the effects of intragastric infusions of equal volumes of water, dioctyl sodium sulfosuccinate, and magnesium sulfate on fecal composition and output in clinically normal horses." American Journal of Veterinary Research 53, no. 8 (1992): 1347–53. http://dx.doi.org/10.2460/ajvr.1992.53.08.1347.

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Summary A Latin square design was used to compare the effects of laxatives and a corresponding volume of water on gastrointestinal tract function in 4 healthy horses. Horses were intragastrically infused with each of the following: dioctyl sodium sulfosuccinate (dss; 50 mg/kg of body weight); magnesium sulfate (0.5 g/kg—low dosage); magnesium sulfate (1.0 g/kg—high dosage); and an equal volume of water (6 L) given as a control infusion. From 5 to 33 hours after the high dosage of magnesium sulfate, feces were slightly softer than usual in all horses. In 1 horse, dss caused mild colic, hyperpne

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G., Gayathry, and Murugesan R. "Laxative Properties of Bacterial Cellulose Isolated from Gluconacetobacter xylinum sju-1 against Loperamide Induced Constipated Sprague-Dawley Rats." Journal of Scientific Research & Reports 14, no. 6 (2017): 1–7. https://doi.org/10.9734/JSRR/2017/34631.

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<strong>Aims: </strong>To evaluate the laxative properties of bacterial cellulose (BC) isolated from <em>Gluconacetobacter xylinum</em> sju-1 against loperamide induced constipated Sprague-Dawley rats. <strong>Study Design:</strong> Completely Randomised Design (CRD). <strong>Place and Duration of Study:</strong> Department of Agricultural Microbiology,Tamil Nadu Agricultural University (TNAU), Coimbatore, Tamil Nadu and Kovai Medical College Hospital, KMCH College of Pharmacy, Institute Animal House Facility, Coimbatore, Tamil Nadu between March 2013- April 2014. <strong>Methodology:</strong>

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Bahmani, Ehsan, Fariba Bahmani, and Saber Abbaszadeh. "Ethnobotanical Study of Effective Medicinal Plants as Laxative (Anti-constipation): A Case Study in Arasbaran Forests, Northwest Iran." Journal of Biochemicals and Phytomedicine 2, no. 2 (2023): 59–63. http://dx.doi.org/10.34172/jbp.2023.12.

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Introduction: Constipation is recognized as a common gastrointestinal problem that many sick and healthy individuals suffer from. Laxative therapy is a reliable way to treat constipation. Several medicinal plants exert laxative potential. Hence, we decided to identify medicinal plants with laxative properties in Arasbaran Forests, East Azerbaijan Province, Northwest Iran. Methods: This ethnobotanical study was conducted in Arasbaran Forests, East Azerbaijan Province, and Northwest Iran from October 2022 to December 2022. Questionnaires were distributed among 20 traditional medicine doctors and

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Sari, Yuli Perwita, and Dipta Bthari Candraruna. "The Potential of Polysaccharides from Various Plants as Constipation Treatment." Journal of Applied Food Technology 10, no. 2 (2023): 48–57. http://dx.doi.org/10.17728/jaft.20621.

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Constipation is one of the disorders of Irritable Bowel Syndrome (IBS). Lack of consumption of water and food with fiber are some of the causes of constipation. Treatment for constipation patients can be solved by administering laxatives through drugs (pharmaceuticals) or using polysaccharide parts from plants. There are at least three types of laxatives: bulking agents (having the ability to bulk up), osmotic agents, and stimulants. Polysaccharides can be sourced from whole or some parts of the plants. Each type of plant has different polysaccharide components, and their effects on constipati

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Laiyemo, Adeyinka O., Kolapo A. Idowu, Clinton Burnside, et al. "Comparison of patterns of laxative ingestion to improve bowel preparation for colonoscopy: a pilot randomized clinical trial." Endoscopy International Open 08, no. 05 (2020): E617—E622. http://dx.doi.org/10.1055/a-1118-3526.

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Abstract Background and study aims Negative experiences with bowel preparation are a barrier to uptake of colonoscopy. The aim of this study was to examine the impact of different flavoring of polyethylene glycol (PEG) laxatives on patient satisfaction with and adequacy of bowel preparation during colonoscopy. Patients and methods This was a single-blind (endoscopist), parallel design, randomized trial (NCT 02062112) during which patients scheduled for colonoscopy were assigned to one of three groups: Group 1 (no laxative flavoring, n = 84); Group 2 (flavored entire laxative, n = 90) and Group

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Seniuk, Igor, Bashar Jabbar Ali Al-Sahlanee, Abdulhadi Ashour Bakri Bakri, Vira Kravchenko, and Oksana Shovkova. "Study of laxative and hepatoprotective activity of extracts obtained from Prunus domestica fruits." Pharmacia 68, no. 2 (2021): 485–92. http://dx.doi.org/10.3897/pharmacia.68.e64159.

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The experimental work focused on the study of the pharmacological properties of extracts obtained from the Prunus domestica fruits to create a prospective laxative drug with moderate hepatoprotective properties. Prunus domestica fruit extracts have been shown to have a pronounced laxative and moderate hepatoprotective effect. Extract containing fibers at a dose of 200 mg/kg was selected as the most active extract for laxative and hepatoprotective activity among all extracts from the Prunus domestica fruits. It was conventionally named “Prunophyte”. Studies of the specific pharmacological actio

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Seniuk, Igor, Bashar Jabbar Ali Al-Sahlanee, Abdulhadi Ashour Bakri Bakri, Vira Kravchenko, and Oksana Shovkova. "Study of laxative and hepatoprotective activity of extracts obtained from Prunus domestica fruits." Pharmacia 68, no. (2) (2021): 485–92. https://doi.org/10.3897/pharmacia.68.e64159.

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The experimental work focused on the study of the pharmacological properties of extracts obtained from the Prunus domestica fruits to create a prospective laxative drug with moderate hepatoprotective properties. Prunus domestica fruit extracts have been shown to have a pronounced laxative and moderate hepatoprotective effect. Extract containing fibers at a dose of 200 mg/kg was selected as the most active extract for laxative and hepatoprotective activity among all extracts from the Prunus domestica fruits. It was conventionally named "Prunophyte". Studies of the specific pharmacological actio

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Attard, Azizah, Andrew Iles, Stephen Attard, Nathan Atkinson, and Anita Patel. "Clozapine: why wait to start a laxative?" BJPsych Advances 25, no. 6 (2019): 377–86. http://dx.doi.org/10.1192/bja.2019.42.

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SUMMARYClozapine, the antipsychotic of choice for treatment-resistant schizophrenia, has a number of side-effects, some of which are potentially life-threatening. Historically viewed as a relatively minor side-effect, there is increasing awareness of the potentially severe sequalae of constipation secondary to clozapine-induced gastrointestinal hypomotility (CIGH). These include ileus, intestinal obstruction, bowel ischaemia, gastrointestinal necrosis, toxic megacolon and death. CIGH is significantly more common than clozapine-induced blood dyscrasias and has a higher mortality rate. Although

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Seo, Ji Yeon, Seong Soon Kim, Hyo Jung Kim, Kwang-Hyeon Liu, Hak-Yong Lee, and Jong-Sang Kim. "Laxative effect of peanut sprout extract." Nutrition Research and Practice 7, no. 4 (2013): 262. http://dx.doi.org/10.4162/nrp.2013.7.4.262.

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Gilani, Anwar‐ul‐Hassan, Nauman Aziz, M. A. Khan, Saba Khan, and Viqar Zaman. "Laxative effect of ispaghula: physical or chemical effect?" Phytotherapy Research 12, S1 (1998): S63—S65. http://dx.doi.org/10.1002/(sici)1099-1573(1998)12:1+3.0.co;2-7.

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Khartode, Swati, Chandrakant Sahare, Kiran Shinde, Sushant Shinde, Chagan Khartode, and Namdev Jagtap. "Raisins with clarified butter or ghee for the relief of acute and chronic constipation - A Clinical Study." American Journal of Food Sciences and Nutrition 3, no. 2 (2021): 1–15. http://dx.doi.org/10.47672/ajfsn.816.

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Background: Constipation is a very distressful symptom, affecting to all age group. The only treatment is laxatives, which is having many adverse effects mainly dependency on laxatives. Purpose: To evaluate the laxative effect of raisins and to get relief from daily dependency on laxative medicines for acute and chronic constipation Methods: Interventional / Experimental study of raisins and clarified butter or ghee performed at ‘Vishwaraj Hospital’ Pune, Maharashtra, India from March 2021 to June 2021, after appropriate ethical approval obtained from the Vishwaraj Hospital’s Ethic

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Kon, Risako, Miho Yamamura, Yukari Matsunaga, et al. "Laxative effect of repeated Daiokanzoto is attributable to decrease in aquaporin-3 expression in the colon." Journal of Natural Medicines 72, no. 2 (2018): 493–502. http://dx.doi.org/10.1007/s11418-018-1174-1.

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Abstract Daiokanzoto (DKT) exerts its laxative effect via colonic inflammation caused by sennoside A in Daio (rhubarb). Previously, we showed that the laxative effect of sennoside A is related to decreased aquaporin-3 (AQP3) expression in mucosal epithelial cells due to colonic inflammation. We also found that a combination of glycyrrhizin, an ingredient in Kanzo (glycyrrhiza), and sennoside A attenuates the inflammatory response induced by sennoside A and reduces its laxative effect. These findings indicate that DKT may be a long-term treatment for chronic constipation, but there is no eviden

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Ikarashi, Nobutomo, Ayako Mimura, Risako Kon, et al. "The concomitant use of an osmotic laxative, magnesium sulphate, and a stimulant laxative, bisacodyl, does not enhance the laxative effect." European Journal of Pharmaceutical Sciences 45, no. 1-2 (2012): 73–78. http://dx.doi.org/10.1016/j.ejps.2011.10.024.

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Ladas, Spiros D., and Sotirios A. Raptis. "Honey, Fructose, Absorption and the Laxative Effect." Nutrition 15, no. 7-8 (1999): 591–92. http://dx.doi.org/10.1016/s0899-9007(99)00092-1.

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AUTORE, G. "Kinins and the laxative effect of phenolphthalein." Pharmacological Research 22 (October 1990): 105–6. http://dx.doi.org/10.1016/1043-6618(90)90830-7.

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De Lisle, Robert C., Eileen Roach, and Kyle Jansson. "Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestine." American Journal of Physiology-Gastrointestinal and Liver Physiology 293, no. 3 (2007): G577—G584. http://dx.doi.org/10.1152/ajpgi.00195.2007.

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The accumulation of mucus in affected organs is characteristic of cystic fibrosis (CF). The CF mouse small intestine has dramatic mucus accumulation and exhibits slower interdigestive intestinal transit. These factors are proposed to play cooperative roles that foster small intestinal bacterial overgrowth (SIBO) and contribute to the innate immune response of the CF intestine. It was hypothesized that decreasing the mucus accumulation would reduce SIBO and might improve other aspects of the CF intestinal phenotype. To test this, solid chow-fed CF mice were treated with an osmotic laxative to i

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Plotnikova, E. Yu, T. Yu Gracheva, M. N. Sinkovа, and L. K. Isakov. "The role of dietary fiber in the correction of digestion and constipation of various etiologies." Medical Council, no. 14 (October 11, 2019): 99–106. http://dx.doi.org/10.21518/2079-701x-2019-14-99-106.

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Psyllium is a predominantly soluble fiber among other natural plant-based dietary fiber used in food and pharmaceuticals and is sold as a laxative fiber. Isphagula (lat. ispaghula)– international nonproprietary name of a medicine of «psyllium». Accordingly to ATX belongs to the group of «Laxatives», subgroup «A06AC «Laxatives increasing volume of intestinal contents» (Bulking laxatives) and has the following code and name: «A06AC01 «Ispaghula» (plantain oval seeds)». Isphagula is a medical dietary fiber; in the context of gastrointestinal problems in terms of «ispaghula» and «psyllium» are syn

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Mamadou, Dosso, Kouamé YaoYves, Coulibaly Adama, and Soro Gninnatchan Issouf. "Saba senegalensis (A.DC) Pichon (Apocynaceae): Treatment of Loperamide-induced Constipation in Mice." Annual Research & Review in Biology 40, no. 2 (2025): 54–61. https://doi.org/10.9734/arrb/2025/v40i22200.

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This study aimed to assess the laxative properties of an aqueous extract of Saba senegalensis leaves, an African medicinal plant, in mice. To this end, tests were carried out to assess the laxative activity of the aqueous extract of Saba senagalenisis leaves and its effect on intestinal motility. As regards the evaluation of its laxative activity, four batches of five mice, non-constipated and constipated with loperamide, were formed. Batch 1 served as a control, while batch 2 received Forlax, a reference osmotic laxative. Batches 3 and 4 were treated orally with Saba senegalensis with concent

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Edi Kamal, Sainal, Muhammad Saharuddin, and Jumrah Jumrah. "Potential of Pineapple (Ananas comocus (L.) Merr.) Flesh as a Laxative in Mice (Mus muscullus)." Jurnal Farmasi Sandi Karsa 9, no. 1 (2023): 52–59. http://dx.doi.org/10.36060/jfs.v9i1.122.

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The pineapple plant, Ananas comocus (L) Merr, has growing shoots at the base that grow into a midrib. The sword-like leaves are strong and substantial. For defecation, the bromelin enzyme, which is contained in pineapples, is frequently used as a laxative (constipation). The purpose of this study was to ascertain the laxative effects of pineapple flesh (Ananas comocus (L) Merr.) extract and the dosages at which it was effective. The Pharmacology Laboratory, Faculty of Mathematics and Natural Sciences, Pancasakti University, used an experimental study design. In this investigation, 25 mice were

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Dhande, S. R., S. P. Bhutkar, and J. V. Mahadik. "EFFECT OF HARITAKI CHURNA ON CARDIOPROTECTIVE ACTION OF ARJUNA IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS." INDIAN DRUGS 54, no. 01 (2017): 41–48. http://dx.doi.org/10.53879/id.54.01.10603.

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Co-administration of prescribed drug with that of over the counter products may either lead to altered therapeutic effect, adverse effects or depleted efficacy of one or both drugs. One such example is geriatric patients being treated with ayurvedic cardioprotectives formulations for ischemia generally suffer from bowel movement discomfort and tend to consume herbal laxatives simultaneously without physician’s consent. The proposed study was undertaken to determine whether any interaction exists when Arjuna, a cardioprotective agent is concomitantly administered orally with Haritaki churna, a

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Jannah, Isnaini Nur, Arifa Mustika, and Edith Frederika Puruhito. "Reduction of Constipating Scoring System Among Women Aged 18-25 Years Old as A Result of Decocted Trengguli (Cassia fistula L.)." Journal Of Vocational Health Studies 1, no. 2 (2017): 58. http://dx.doi.org/10.20473/jvhs.v1.i2.2017.58-62.

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Background: Constipation is a condition when someone has difficulty to defecate. Constipation is indicated by hard and large size stool as well as a decrease frequency of bowel movement. Commonly, constipation is indicated by anxiety during bowel movement due to disruption defecation. Constipation can cause severe stress resulting from discomforts for patient. The severity of the constipation can be measured using the Constipation Scoring System (CSS). CSS is a scoring system for patient, which based on the answers about the symptoms being asked in the questionnaire. One of the herbs to handle

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HARA, Hideaki, Yasuaki ISE, Nobutaka MORIMOTO, et al. "Laxative Effect of Agarwood Leaves and Its Mechanism." Bioscience, Biotechnology, and Biochemistry 72, no. 2 (2008): 335–45. http://dx.doi.org/10.1271/bbb.70361.

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Spallek, A., A. Meister, and G. F. Schusser. "Laxative effect of gastric emptying in normal horses." Pferdeheilkunde Equine Medicine 23, no. 4 (2007): 366–68. http://dx.doi.org/10.21836/pem20070407.

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Bekker, A. R., Yu V. Bykov, A. O. Shkurat, and A. S. Voronina. "Magnesium Preparations in Psychiatry, Addiction Medicine, Neurology and General Medicine (Part I. History)." Acta Biomedica Scientifica 4, no. 3 (2019): 63–80. http://dx.doi.org/10.29413/abs.2019-4.3.9.

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The use of magnesium preparations in medicine has a long history. According to some sources, first attempts by humans to consume magnesium- and calcium-rich minerals orally, presumably for medicinal purposes, could have occurred even in prehistoric times. First attempts to use natural magnesium-calcium alkaline materials to increase the bioavailability of the alkaloids of some psychoactive plants, such as betel, tobacco, and coca, also date back to prehistoric times.Later, several ancient authors, in particular, Hippocrates II, Claudius Galen and Soran of Ephesus, have described the profound l

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Uthia, Rahimatul, Devina Prima Yolanda, Aried Eriadi, and Dwi Dinni Aulia Bakhtra. "Laxative Activity Test of Gynura procumbens (Lour.) Merr. Leave on White Male Mice Induced by Loperamide." Metamorfosa: Journal of Biological Sciences 6, no. 2 (2019): 137. http://dx.doi.org/10.24843/metamorfosa.2019.v06.i02.p01.

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Constipation is a symptom of a problematic, non-smooth and irregular defecation process. While laxative is a substance that stimulates intestinal peristalsis as a reflex of direct stimulation of the intestinal wall that can cause or facilitate defecation. This study aimed to determine the ethanol extract of the leaves of Gynura procumbens (L.) Merr. effect as a laxative in white male mice induced by loperamide. The methods used for laxative testing are defecation patterns and intestinal transit methods. The parameters observed included frequency of defecation, stool consistency, stool weight e

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Bashar Jabbar Ali Al-Sahlanee, O. Yu Koshova, and I. V. Senyuk. "THE INFLUENCE OF EXTRACTS FROM PRUNUS DOMESTICA ON DISORDERS OF INTESTINAL PERISTALSIS INDUCED BY BARIUM CHLORIDE ACTION IN MICE." Фармацевтичний часопис, no. 4 (December 9, 2019): 66–72. http://dx.doi.org/10.11603/2312-0967.2019.4.10669.

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The aim of the work. To confirm by experimental studies the laxative activity of fiber-containing extract and extract with polysaccharide complex obtained from the Prunus domestica fruits in a model of intestinal peristalsis damage induced by barium chloride in mice, to identify the most effective extract among them and determine its effective dose. Materials and Methods. Dry extracts from the Prunus domestica fruits (fiber-containing extract (PEF) and extract with polysaccharide complex (PEPC)) were used in the experimental studiesThe investigated extracts were obtained by the original

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Malanicheva, T. G., N. V. Ziatdinova, and Ch I. Ashrafullina. "Efficient methods of therapy of pediatric functional constipation." Meditsinskiy sovet = Medical Council, no. 19 (November 14, 2022): 105–9. http://dx.doi.org/10.21518/2079-701x-2022-16-19-105-109.

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Constipation holds an important place among the functional gastrointestinal disorders. The following are among the main reasons for the development of functional constipation: alimentary factors, impaired nervous and endocrine regulation (functional immaturity of the colon, perinatal injury of the central nervous system, endocrine disease), psychosomatic factors, hypodynamia, previous intestinal infections, iatrogenic effects, food allergies and anorectal pathology, genetic predisposition. Treatment of constipation should be comprehensive and include lifestyle maneuvers, dietary recommendation

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Hale, Martin E., James E. Wild, Tadaaki Yamada, et al. "Naldemedine is effective in the treatment of opioid-induced constipation in patients with chronic non-cancer pain who had a poor response to laxatives." Therapeutic Advances in Gastroenterology 14 (January 2021): 175628482110323. http://dx.doi.org/10.1177/17562848211032320.

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Background: Two studies demonstrated the efficacy and safety of naldemedine in adult patients with chronic non-cancer pain and opioid-induced constipation (OIC). However, no studies have compared the efficacy of peripherally acting µ-opioid receptor antagonists in patients with adequate and inadequate responses to prior OIC therapy with laxatives. This post hoc analysis of integrated data from the two previous studies compared the efficacy of naldemedine in patients who were unsuccessfully treated with laxatives [poor laxative responders (PLRs)] with those who either did not receive laxatives

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George, Mathew, Lincy Joseph, and Nimisha M. Paul. "Screening of Laxative Effect of Leaves of Ficus auriculata." International Journal of Current Research and Academic Review 4, no. 7 (2016): 44–49. http://dx.doi.org/10.20546/ijcrar.2016.407.006.

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Sivakumar, A., and T. Panneer Selvam. "Laxative Effect of Eugenia Jambolana Crude Leaf Bud Extract." Pharmacology & Pharmacy 02, no. 03 (2011): 164–67. http://dx.doi.org/10.4236/pp.2011.23023.

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Round, Andrew M., Min Cheol Joo, Carolyn M. Barakso, Nader Fallah, Vanessa K. Noonan, and Andrei V. Krassioukov. "Neurogenic Bowel in Acute Rehabilitation Following Spinal Cord Injury: Impact of Laxatives and Opioids." Journal of Clinical Medicine 10, no. 8 (2021): 1673. http://dx.doi.org/10.3390/jcm10081673.

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Objective: To explore the association between bowel dysfunction and use of laxatives and opioids in an acute rehabilitation setting following spinal cord injury (SCI). Methods: Data was collected regarding individuals with acute traumatic/non-traumatic SCI over a two-year period (2012–2013) during both the week of admission and discharge of their inpatient stay. Results: An increase in frequency of bowel movement (BM) (p = 0.003) and a decrease in frequency of fecal incontinence (FI) per week (p < 0.001) between admission and discharge was found across all participants. There was a reductio

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Zhong, Xue-Mei, and Xu-Rui Liu. "Effect of laxative use and laxative type on colorectal cancer risk: A pooling up analysis and evidence synthesis." Oncology Letters 29, no. 6 (2025): 1–8. https://doi.org/10.3892/ol.2025.15030.

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Choi, Jae-Suk, Joo Wan Kim, Ki-Young Kim, Jong-Kwang Lee, Jae Hak Sohn, and Sae-Kwang Ku. "Synergistic Effect of Fermented Rice Extracts on the Probiotic and Laxative Properties of Yoghurt in Rats with Loperamide-Induced Constipation." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/878503.

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Aim. The objective was to evaluate the synergistic effects of fermented rice extracts (FRe) on the laxative and probiotic properties of yoghurt in rats with loperamide-induced constipation. Methods. After constipation induction, yoghurt containing FRe (BFRe; 0.05%, 0.1%, or 1%) was administered orally once per day for 6 days.Results. Loperamide treatment caused marked decreases in fecal pellet numbers and water content discharged, as well as in the surface mucosal thickness of the colonic lumen, intestinal charcoal transit ratio, thickness, and number of mucous-producing goblet cells in the co

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Zhan, Yu, Xuegui Tang, Hong Xu та Shiyu Tang. "Maren Pills Improve Constipation via Regulating AQP3 and NF-κB Signaling Pathway in Slow Transit Constipation In Vitro and In Vivo". Evidence-Based Complementary and Alternative Medicine 2020 (23 липня 2020): 1–12. http://dx.doi.org/10.1155/2020/9837384.

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Background. Maren pills have been used to treat constipation. Aquaporin 3 (AQP3) plays a vital role in regulating water transfer in the colon. It has been reported that the downregulation of AQP3 can regulate liquid water metabolism and intestinal permeability in irritable bowel syndrome (IBS) rats’ colon via NF-κB pathway. In this study, we investigated whether the laxative effect of Maren pills is associated with the regulation of AQP3 and NF-κB signaling pathway in the colon. Methods. The compound diphenoxylate suspension-induced STC rats received Maren pills intragastrically for 1 consecut

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Hannah, Hannah, M. Juffrie, and S. Yati Soenarto. "Effectiveness of synbiotics as laxative agent for constipation in children." Paediatrica Indonesiana 48, no. 3 (2016): 136. http://dx.doi.org/10.14238/pi48.3.2008.136-41.

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Background Constipation in children can cause serious problems.Laxative is needed for the management of constipation. Orallaxative has been used frequently, even though a safe oral laxativeagents for children is limited. Prebiotic and probiotic have alreadybeen proven to have laxative effect in constipation in children andadults. The effectiveness of these agents as a laxative has not beenproven yet.Objective To evaluate the effectiveness of laxative synbiotic inconstipation in children compared to that of fiber foods.Methods A randomized double blind controlled trial wasconducted on children

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Luo, DanDan, Chao Qu, ZhenBiao Zhang, et al. "Granularity and Laxative Effect of Ultrafine Powder of Dendrobium officinale." Journal of Medicinal Food 20, no. 2 (2017): 180–88. http://dx.doi.org/10.1089/jmf.2016.3827.

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Leng-Peschlow, Elke. "Sennoside-lnduced Secretion and Its Relevance for the Laxative Effect." Pharmacology 47, no. 1 (1993): 14–21. http://dx.doi.org/10.1159/000139838.

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Lorenzo De Fraia, Stephanos Christodoulides, and Ioannis Patrikios. "Laxative effect of prebiotics in chronic constipation: Mechanisms of action." Magna Scientia Advanced Biology and Pharmacy 9, no. 2 (2023): 008–13. http://dx.doi.org/10.30574/msabp.2023.9.2.0046.

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Constipation is a condition that affects a consistent part of the general population, with increasing numbers of incidence worldwide. Its causes can be attributed to several factors. One of these factors (and one of the most relevant causes) is dietary choices. For instance, poor nutrition habits have been shown to adversely affect the function of the digestive tract, eliciting abnormal physiological responses that might lead to constipation. Prebiotics are specialized types of fermentable fibres which have been hypothesised to play a beneficial role in the treatment of chronic idiopathic cons

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Sheptulin, A. A. "Modern Possibilities of Using Lactulose in Clinical Practice." Russian Journal of Gastroenterology, Hepatology, Coloproctology 33, no. 4 (2023): 70–75. http://dx.doi.org/10.22416/1382-4376-2023-33-4-70-75.

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Aim of the publication. To present an overview of current literature data on the possibilities of application of lactulose in clinical practice.Key findings. Lactulose is a synthetic disaccharide belonging to the class of osmotic laxatives. Officially permitted indications for its appointment in Russian Federation are functional constipation (including in children, the elderly and senile, pregnant women and women in postpartum period), an obstipation type of irritable bowel syndrome, the need to soften the consistency of feces in hemorrhoids and anal fissures, after operations on the colon and

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Karmakar, Utpal Kumar, Animesh Paul, Pritam Kundu, and Progga Paramita Paul. "Exploration of Anthelmintic, Blood Coagulant, Diuretic and Laxative Activities of Different Solvent Fractions of Flagellaria Indica Leaves." Jordan Journal of Pharmaceutical Sciences 16, no. 3 (2023): 655–70. http://dx.doi.org/10.35516/jjps.v16i3.976.

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Flagellaria indica (Family: Flagellariaceae) is a common climbing plant found primarily in tropical regions of many countries. The plant has various traditional uses, although most of them lack scientific published reports. The crude ethanolic extract of F. indica leaves was fractionated based on polarity using water, ethyl acetate, and n-hexane. Biological screening was conducted on the anthelmintic, blood coagulation, diuretic, and laxative activities of the water, ethyl acetate, and n-hexane fractions of F. indica leaves. In the anthelmintic test, the n-hexane fraction showed a moderate eff

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Chda, Alae, Youssef Mahou, Youssra Znata, et al. "Investigation on the gastrointestinal properties of ethanolic extract of Cannabis sativa through in vivo and in vitro approaches." Journal of Herbmed Pharmacology 12, no. 3 (2023): 344–55. http://dx.doi.org/10.34172/jhp.2023.37.

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Introduction: For thousands of years, Cannabis sativa has been used for its medical and recreational benefits. Nowadays, there is an increasing interest in the use of C. sativa and its non-psychoactive products/effects to treat certain diseases. This study was conducted to examine the gastrointestinal effects of a sequential ethanolic fraction of C. sativa threshing residues (EFCS). Methods: In vivo and in vitro approaches were used to investigate the gastrointestinal properties of EFCS. Antidiarrheal, antibacterial, spasmodic, laxative, and antiulcer effects were tested respectively against c

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Shekunova, E. V., E. V. Mazukina, V. A. Vavilova, et al. "Experimental Study of the Efficacy and Safety of a New PEG-Based Laxative." Safety and Risk of Pharmacotherapy 10, no. 2 (2022): 176–95. http://dx.doi.org/10.30895/2312-7821-2022-10-2-176-195.

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Bowel-cleansing PEG-based agents, including Moviprep®, are commonly used to prepare the large intestine for diagnostic examinations. PLNV-next is a newly developed fixed combination medicinal product with a composition similar to that of Moviprep®.The aim of the study was to estimate the pharmacological efficacy and toxicity of PLNV-next.Materials and methods: The study evaluated pharmacological efficacy of four formulations of PLNV-next in comparison with Moviprep® after a single administration in a therapeutic dose to outbred rats. The evaluation was carried out based on the laxative effect

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He, Yanghang, Gang Liu, Chen Xia, et al. "Laxative effect of mulberry ferment on two models of constipated mice." Journal of Functional Foods 90 (March 2022): 104971. http://dx.doi.org/10.1016/j.jff.2022.104971.

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Gull, Imtiaz. "Effect of laxative polyherbal paste for loperamide induced constipation in rats." American Journal of Translational Research 16, no. 9 (2024): 4714–27. http://dx.doi.org/10.62347/xsfh4004.

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Eor, Ju Young, Pei Lei Tan, Sei Mi Lim, et al. "Laxative effect of probiotic chocolate on loperamide-induced constipation in rats." Food Research International 116 (February 2019): 1173–82. http://dx.doi.org/10.1016/j.foodres.2018.09.062.

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Williams, Rachel E., Nevzeta Bosnic, Carolyn T. Sweeney, et al. "Prevalence of Opioid Dispensings and Concurrent Gastrointestinal Medications in Quebec." Pain Research and Management 13, no. 5 (2008): 395–400. http://dx.doi.org/10.1155/2008/435738.

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BACKGROUND: Opioids are frequently prescribed for moderate to severe pain. A side effect of opioid usage is the inhibition of gastrointestinal (GI) motility, known as opioid-induced bowel dysfunction (OBD). OBD is typically treated prophylactically with laxatives and/or acid suppressants.AIM: The present study describes the prevalence of outpatient opioid dispensing, opioid patient demographics, and concomitant dispensing of opioids and GI medications in the Quebec Public Prescription Drug Insurance Plan in 2005.METHODS: Using a retrospective cohort design, opioid dispensings were identified u

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