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Journal articles on the topic 'Laxatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Werth, Barry L., and Sybèle-Anne Christopher. "Laxative Use in the Community: A Literature Review." Journal of Clinical Medicine 10, no. 1 (2021): 143. http://dx.doi.org/10.3390/jcm10010143.

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Laxatives are widely available without prescription and, as a consequence, they are commonly used for self-management of constipation by community-dwelling adults. However, it is not clear to what extent laxatives are used. Nor is it clear how laxatives are chosen, how they are used and whether consumers are satisfied with their performance. This review of published literature in the last 30 years shows the prevalence of laxative use in community-dwelling adults varied widely from 1% to 18%. The prevalence of laxative use in adults with any constipation (including both chronic and sporadic con

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Konovalova, N. V., O. V. Stopinchuk, and O. Y. Krikus. "Inconvenient topic: laxative abuse. review and clinical case." Reports of Vinnytsia National Medical University 24, no. 4 (2020): 720–25. http://dx.doi.org/10.31393/reports-vnmedical-2020-24(4)-28.

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Annotation. Laxatives are drugs with different mechanism of action that are used to treat or prevent constipation. Use of laxatives to control body weight is considered a dangerous tendency, especially among young women with eating disorders. Natural or synthetic stimulant purgatives are the most commonly used for weight loss because they are cost-effective, have rapid onset of action, and available in various dosage forms. Excessive use of laxatives results in a gradual efficacy decrease causes specific damage of the gastrointestinal tract, other organs and systems. This condition is known as

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Sazhin, Vladimir, and Pushkal Pushkal. "Predictors of laxative use in inpatients with schizophrenia on clozapine." Australasian Psychiatry 30, no. 1 (2021): 105–9. http://dx.doi.org/10.1177/10398562211042368.

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Objectives: Constipation, a clinical manifestation of gastrointestinal hypomotility, is a common and potentially serious complication of clozapine therapy, requiring laxatives for its prevention and treatment. We explored the predictive factors of the increased laxative use in inpatients receiving a long-term clozapine therapy. Methods: In the cross-sectional study of 93 patients in a psychiatric rehabilitation hospital, we examined a four-week prevalence of laxative use and a range of demographic and clinical factors associated with the number of prescribed laxatives. Results: Seventy-four pe

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Wahyuni, Eko Sari, Rudi Hamarno, Taufan Arif, Erlina Suci Astuti, and Rossyana Septiasih. "Effects Of Laxatives On Postoperative Intestinal Sound Recovery." Health Frontiers 2, no. 1 (2024): 1–7. https://doi.org/10.62255/mjhp.v2i1.124.

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Intestinal sound is produced by muscle movements in the digestive tract. The return of intestinal sound after surgery is an important indicator for patients to return to eating and drinking normally. This study aimed to determine whether the administration of laxatives before surgery can speed up the recovery of intestinal sound in patients undergoing surgery with general anesthesia. The study involved 30 patients divided into two groups: a laxative group and a control group. The laxative group received laxatives before surgery, while the control group did not. Intestinal sound recovery time w

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Bruin, Frans de, Karin Hek, Jan van Lieshout, et al. "Laxative co-medication and changes in defecation patterns during opioid use." Journal of Oncology Pharmacy Practice 25, no. 7 (2018): 1613–21. http://dx.doi.org/10.1177/1078155218801066.

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Introduction Opioid-induced constipation is a clinically relevant side effect and a cause of potentially avoidable drug-related hospital admissions. Objectives To describe the presence of laxative co-medication, the reasons for not starting laxatives and to evaluate changes in stool patterns of opioid initiators. Methods In this observational study community pharmacists evaluated the availability of laxative co-medication in starting opioid users and registered reasons for non-use. Two opioid initiators per pharmacy were invited to complete questionnaires (‘Bristol stool form scale’ and ‘Rome

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Yamamoto, Sayuri, Wataru Ohashi, Yoshiharu Yamaguchi, et al. "Factors Associated with Defecation Satisfaction among Japanese Adults with Chronic Constipation." Journal of Clinical Medicine 13, no. 11 (2024): 3216. http://dx.doi.org/10.3390/jcm13113216.

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Background: Constipation causes substantial morbidity worldwide. Methods: This survey assessed constipation-related factors in Japan using the Japanese version of the Irritable Bowel Syndrome Quality of Life (IBS-QOL-J) instrument. We also examined the relationship among laxative type, Bristol Stool Form Scale (BSFS) scores, and treatment cost. Finally, we examined differences in satisfaction scores according to laxative type, treatment type, treatment cost, and BSFS score. Results: IBS-QOL-J was higher among those taking salt and/or irritation laxatives. Those paying >JPY 5000 (USD 50.00)

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Hoang Anh, Trung, Phung-Anh Nguyen, Anh Duong, et al. "Contact Laxative Use and the Risk of Arteriovenous Fistula Maturation Failure in Patients Undergoing Hemodialysis: A Multi-Center Cohort Study." International Journal of Environmental Research and Public Health 19, no. 11 (2022): 6842. http://dx.doi.org/10.3390/ijerph19116842.

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Laxatives are commonly prescribed for constipation management; however, they are recognized as an independent factor associated with cardiovascular diseases. Arteriovenous fistula (AVF) is the closest to the ideal model of hemodialysis (HD) vascular access and part of the cardiovascular system. Our study aims to explore the association of contact laxative use with AVF maturation outcomes in patients undergoing HD. We conducted a multi-center cohort study of 480 contact laxative users and 472 non-users who had undergone initial AVF creation. All patients were followed until the outcomes of AVF

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White, Nicole C., Rafael Mendo-Lopez, Konstantinos Papamichael, et al. "Laxative Use Does Not Preclude Diagnosis or Reduce Disease Severity in Clostridiodes difficile Infection." Clinical Infectious Diseases 71, no. 6 (2019): 1472–78. http://dx.doi.org/10.1093/cid/ciz978.

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Abstract Background To optimize utility of laboratory testing for Clostridiodes difficile infection (CDI), the 2017 Infectious Diseases Society of America–Society for Healthcare Epidemiology of America (IDSA-SHEA) clinical practice guidelines recommend excluding patients from stool testing for C. difficile if they have received laxatives within the preceding 48 hours. Sparse data support this recommendation. Methods Patients with new-onset diarrhea (≥3 bowel movements in any 24-hour period in the 48 hours before stool collection) and a positive stool C. difficile nucleic acid amplification tes

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Tao, Heqing, Ligang Liu, Weipeng Lu, et al. "The Effects of Prophylactic Laxative Use on Critically Ill Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study." Diseases 12, no. 11 (2024): 274. http://dx.doi.org/10.3390/diseases12110274.

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Objective: To investigate the effects of prophylactic use of stimulant laxatives and/or docusate on the clinical outcomes in critically ill patients who required mechanical ventilation (MV). Methods: A single-center, retrospective, cohort study was conducted. Patients who received MV in the first 24 h after intensive care unit (ICU) admission were enrolled and divided into four groups: non-laxative, stimulant laxatives, docusate, and stimulant laxatives–docusate combination. The primary outcome was in-hospital mortality. The major secondary outcomes included ICU-free days and ventilator-free d

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Pranoto, Wiji Joko, Supriatmo Supriatmo, Melda Deliana, and Atan Baas Sinuhaji. "Oral versus rectal laxatives for functional constipation in child." Paediatrica Indonesiana 56, no. 3 (2016): 162. http://dx.doi.org/10.14238/pi56.3.2016.162-6.

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Background Functional constipation is a common childhood condition. Benefits of oral and rectal laxatives in terms of recovery and recurrence in children with functional constipation are still controversial.Objective To compare the effectiveness of oral and rectal laxatives in terms of recovery and recurrence in children with functional constipation.Methods Children aged 8 to 17 years who met the Rome III criteria for functional constipation were enrolled in this open randomised trial. Data was collected through questionnaires, interviews, and physical examinations. The participants were rando

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Khartode, Swati, Chandrakant Sahare, Kiran Shinde, Sushant Shinde, Chagan Khartode, and Namdev Jagtap. "Raisins with clarified butter or ghee for the relief of acute and chronic constipation - A Clinical Study." American Journal of Food Sciences and Nutrition 3, no. 2 (2021): 1–15. http://dx.doi.org/10.47672/ajfsn.816.

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Background: Constipation is a very distressful symptom, affecting to all age group. The only treatment is laxatives, which is having many adverse effects mainly dependency on laxatives. Purpose: To evaluate the laxative effect of raisins and to get relief from daily dependency on laxative medicines for acute and chronic constipation Methods: Interventional / Experimental study of raisins and clarified butter or ghee performed at ‘Vishwaraj Hospital’ Pune, Maharashtra, India from March 2021 to June 2021, after appropriate ethical approval obtained from the Vishwaraj Hospital’s Ethic

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Paré, Pierre, and Richard N. Fedorak. "Systematic Review of Stimulant and Nonstimulant Laxatives for the Treatment of Functional constipation." Canadian Journal of Gastroenterology and Hepatology 28, no. 10 (2014): 549–57. http://dx.doi.org/10.1155/2014/631740.

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BACKGROUND: Constipation is an uncomfortable and common condition that affects many, irrespective of age. Since 1500 BC and before, health care practitioners have provided treatments and prevention strategies to patients for chronic constipation despite the significant variation in both medical and personal perceptions of the condition.OBJECTIVE: To review relevant research evidence from clinical studies investigating the efficacy and safety of commercially available pharmacological laxatives in Canada, with emphasis on studies adopting the Rome criteria for defining functional constipation.SE

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Ji-Xu, A., C. Moezinia, N. Lovett, and D. Krishan Sharma. "18 The Use of A Multifactorial Intervention to Improve Bowel Chart Recording and Laxative Prescription in A Tertiary Geriatrics Department." Age and Ageing 49, Supplement_1 (2020): i1—i8. http://dx.doi.org/10.1093/ageing/afz183.18.

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Abstract Introduction Constipation has a high prevalence of 30-40% in those aged over 65. It can lead to complications including delirium, faecal impaction, stercoral ulceration, and bowel obstruction. Although stool charts are used in geriatric wards to monitor bowel movements to guide management of constipation, they are often inconsistently recorded. Similarly, regular laxatives are often not prescribed for constipated patients due to ward pressures or unawareness regarding their importance. Aims Our aims were to audit the rates of recording on stool charts and laxative prescription in a ge

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Sari, Yuli Perwita, and Dipta Bthari Candraruna. "The Potential of Polysaccharides from Various Plants as Constipation Treatment." Journal of Applied Food Technology 10, no. 2 (2023): 48–57. http://dx.doi.org/10.17728/jaft.20621.

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Constipation is one of the disorders of Irritable Bowel Syndrome (IBS). Lack of consumption of water and food with fiber are some of the causes of constipation. Treatment for constipation patients can be solved by administering laxatives through drugs (pharmaceuticals) or using polysaccharide parts from plants. There are at least three types of laxatives: bulking agents (having the ability to bulk up), osmotic agents, and stimulants. Polysaccharides can be sourced from whole or some parts of the plants. Each type of plant has different polysaccharide components, and their effects on constipati

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Boyd, Holly, and Anna Manso de Zuniga. "Clozapine & constipation: an audit of bowel habit monitoring and laxative prescribing in inpatients on clozapine." BJPsych Open 7, S1 (2021): S67. http://dx.doi.org/10.1192/bjo.2021.220.

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AimsTo establish how often bowel habits are monitored in inpatients on clozapineTo determine how many of these patients are prescribed laxatives and whether these are utilisedBackgroundIt's estimated that 30-60% of patients will suffer from constipation whilst on clozapine; this can lead to ileus, intestinal obstruction and bowel ischaemia, all of which can be fatal. Constipation is much more common than clozapine-induced blood dyscrasias, and has a higher mortality rate. Despite this, there is no strict universal framework for bowel habit monitoring equivalent to the compulsory FBC monitoring

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Round, Andrew M., Min Cheol Joo, Carolyn M. Barakso, Nader Fallah, Vanessa K. Noonan, and Andrei V. Krassioukov. "Neurogenic Bowel in Acute Rehabilitation Following Spinal Cord Injury: Impact of Laxatives and Opioids." Journal of Clinical Medicine 10, no. 8 (2021): 1673. http://dx.doi.org/10.3390/jcm10081673.

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Objective: To explore the association between bowel dysfunction and use of laxatives and opioids in an acute rehabilitation setting following spinal cord injury (SCI). Methods: Data was collected regarding individuals with acute traumatic/non-traumatic SCI over a two-year period (2012–2013) during both the week of admission and discharge of their inpatient stay. Results: An increase in frequency of bowel movement (BM) (p = 0.003) and a decrease in frequency of fecal incontinence (FI) per week (p < 0.001) between admission and discharge was found across all participants. There was a reductio

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&NA;. "Laxatives." Reactions Weekly &NA;, no. 354 (1991): 10. http://dx.doi.org/10.2165/00128415-199103540-00041.

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Gasior, Alessandra, Giulia Brisighelli, Karen Diefenbach, et al. "Surgical Management of Functional Constipation: Preliminary Report of a New Approach Using a Laparoscopic Sigmoid Resection Combined with a Malone Appendicostomy." European Journal of Pediatric Surgery 27, no. 04 (2016): 336–40. http://dx.doi.org/10.1055/s-0036-1593606.

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Introduction Functional constipation is a common problem in children. It usually can be managed with laxatives but a small subset of patients develop intolerable cramps and need to be temporarily treated with enemas. The senior author has previously reported: 1) open sigmoid resection as a surgical option, but this did not sufficiently reduce the laxative need, then 2) a transanal approach (with resection of rectosigmoid), but this led to a high rate of soiling due to extensive stretching of the anal canal and loss of the rectal reservoir. The understanding of these procedures' results has led

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Kawamata, *Yasushi, Norio Sugawara, Taro Sasaki, et al. "FACTORS ASSOCIATED WITH THE INITIATION OF LAXATIVE USE IN THE SAME PATIENTS WITH SCHIZOPHRENIA OVER A 20-YEAR PERIOD: RETROSPECTIVE COHORT STUDY." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i356—i357. https://doi.org/10.1093/ijnp/pyae059.633.

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Abstract Background Constipation is a common adverse effect of antipsychotics, but little investigation has been conducted. We aimed to address the factors associated with the initiation of laxative use in the same patients with schizophrenia over a 20-year period. Methods We enrolled patients with schizophrenia attending each hospital (n=14) from April 1, 2021, and retrospectively examined all prescriptions as of April 1, 2016, 2011, 2006, and 2001, every 5 years starting in 2021, for this population. 716 participants with complete data were included in the analysis. The Cochran Q test follow

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Laiyemo, Adeyinka O., Kolapo A. Idowu, Clinton Burnside, et al. "Comparison of patterns of laxative ingestion to improve bowel preparation for colonoscopy: a pilot randomized clinical trial." Endoscopy International Open 08, no. 05 (2020): E617—E622. http://dx.doi.org/10.1055/a-1118-3526.

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Abstract Background and study aims Negative experiences with bowel preparation are a barrier to uptake of colonoscopy. The aim of this study was to examine the impact of different flavoring of polyethylene glycol (PEG) laxatives on patient satisfaction with and adequacy of bowel preparation during colonoscopy. Patients and methods This was a single-blind (endoscopist), parallel design, randomized trial (NCT 02062112) during which patients scheduled for colonoscopy were assigned to one of three groups: Group 1 (no laxative flavoring, n = 84); Group 2 (flavored entire laxative, n = 90) and Group

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Gelder, Chloé Louise, Melissa Bautista, Sidra Arif Awan, and Ian A. Anderson. "Unaccounted for enteral volume loss linked to delayed cerebral ischemia after subarachnoid hemorrhage." Neurosurgical Focus 52, no. 3 (2022): E5. http://dx.doi.org/10.3171/2021.12.focus21603.

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OBJECTIVE Delayed ischemic neurological deficit (DIND) is seen as a clinical manifestation of cerebral vasospasm and is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH). Currently, the standard of care for DIND prevention in patients who have sustained aSAH is prophylactic nimodipine therapy and ensuring adequate fluid intake, alongside other treatments such as bowel care. Osmotic laxatives trap water within the bowel lumen to accelerate the transport of the gut contents through the bowel. Given the potential for DIND secondary to cerebral vaso

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Al-Bahou, Amanda, Rod Quilitz, Yanina Pasikhova, and John Greene. "755. Clostridioides difficile Testing and the Use of Laxatives in Immunocompromised Adults." Open Forum Infectious Diseases 8, Supplement_1 (2021): S474—S475. http://dx.doi.org/10.1093/ofid/ofab466.952.

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Abstract Background Clostridioides difficile infection (CDI) rates have plateaued at historical highs in the United States since 2010 and remains a major health problem. While optimal CDI testing remains unclear, current literature recommends testing patients whose symptoms are not clinically attributable to underlying conditions, e.g., laxatives. At Moffitt Cancer Center, a soft-stop alert was implemented to alert the provider if the patient received a laxative within the previous 48 hours of CDI testing. We aim to evaluate the incidence of CDI rates with prior laxative use in immunocompromis

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Kim, Won Shik, and Beom Jae Lee. "Safe and appropriate use of laxatives for colonoscopy." Journal of the Korean Medical Association 64, no. 8 (2021): 561–69. http://dx.doi.org/10.5124/jkma.2021.64.8.561.

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Background: Appropriate bowel preparation is essential for effective colonoscopy. Inadequate use of bowel preparation solutions reduces patient compliance, makes the detection of lesions such as adenoma difficult, and increases the risk of complication such as perforation. Current Concepts: A 4-L polyethylene glycol (PEG) solution can be safely used for bowel preparation, even in most individuals with underlying diseases. However, it requires a high preparation-volume intake and has poor patient compliance due to its unpleasant taste. Therefore, a 2- or 1- L sulfate-free, PEG-based laxative wa

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Torriani, Francesca, Frank Myers Robert El-Kareh, Minji Kang, Randy Taplitz, and Shira Abeles. "Clostridioides difficile Testing Stewardship for Laxative Use Is Effective and Safe When Combined With Expert Clinical Input." Infection Control & Hospital Epidemiology 41, S1 (2020): s169—s170. http://dx.doi.org/10.1017/ice.2020.696.

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Background: In January 2019, our large academic medical center implemented hard stops for ordering Clostridiodes difficile nucleic acid amplification testing (NAAT), and required a discussion with an infectious diseases physician if the order was placed in a clinical scenario not consistent with the 2017 IDSA/SHEA C. difficile infection (CDI) testing guidelines. Recently, some groups have expressed concerns that requiring the discontinuation of laxatives may delay the diagnosis of CDI and result in serious adverse outcomes. Methods:C. difficile testing stewardship interventions were performed

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Kirkpatrick, F., and P. Crawford. "551 EASING THE STRAIN OF CONSTIPATION IN CARE HOMES." Age and Ageing 50, Supplement_2 (2021): ii8—ii13. http://dx.doi.org/10.1093/ageing/afab116.20.

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Abstract Introduction Older individuals are particularly prone to constipation with a reported prevalence of up 50% for those living in community with the prevalence rising to 70% within nursing homes (De Giorgio et al, 2015 1). Objectives To assess impact of staff education & pharmacist intervention on appropriateness of laxative use: Staff education: Examine the baseline knowledge of care home staff on constipation and laxative use: Formulate an education package to deliver to care home staff on key aspects of laxative use: Evaluate the staff knowledge, post the educational intervention.

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McMillan, Matthew, and Alexandra Jayne Burgess. "Prescribe, Review, Now!: an assessment of adequate PRN analgesia and associated laxative prescribing using Hospital Electronic Prescribing and Medicines Administration (HEPMA)." BMJ Open Quality 12, no. 1 (2023): e002090. http://dx.doi.org/10.1136/bmjoq-2022-002090.

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IntroductionOn HEPMA there is no way to notify a prescriber if patients are regularly accessing PRN (as-required) analgesia. We aimed to assess how well PRN analgesia use is identified, the WHO analgesic ladder and whether laxatives were prescribed with opioid analgesia.Methods3 data collection cycles were carried out for all medical inpatients between February-April 2022. Medication was reviewed to determine: 1) PRN analgesia prescribed? 2) Is the patient accessing it >3 times in 24hours? 3) Con-current laxatives prescribed. Between each cycle, an intervention was implemented. Intervention

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Filho, Aldo J. Peixoto, and M. Nathan Lassman. "Severe Hyperphosphatemia Induced by a Phosphate-Containing Oral Laxative." Annals of Pharmacotherapy 30, no. 2 (1996): 141–43. http://dx.doi.org/10.1177/106002809603000206.

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OBJECTIVE: To describe a case of severe hyperphosphatemia following unintentional overdosage with an oral phosphate laxative, and raise attention to the risks of using such medications in the elderly. CASE SUMMARY: An 84-year-old white woman was admitted with confusion 8 hours after inadvertently ingesting 12 fluid ounces of Fleet Phospho-Soda (instead of the prescribed 1½ fluid ounces) prior to a colonoscopy. Her serum phosphate and ionized calcium concentrations were 10.3 mmol/L and 0.56 mmol/L, respectively. She was treated conservatively with oral phosphate binders and made an uneventful r

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Shelton, Joseph H., Carol A. Santa Ana, Donald R. Thompson, Michael Emmett, and John S. Fordtran. "Factitious Diarrhea Induced by Stimulant Laxatives: Accuracy of Diagnosis by a Clinical Reference Laboratory Using Thin Layer Chromatography." Clinical Chemistry 53, no. 1 (2007): 85–90. http://dx.doi.org/10.1373/clinchem.2006.077883.

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Abstract Background: Surreptitious ingestion of laxatives can lead to serious factitious diseases that are difficult to diagnose. Most cases involve ingestion of bisacodyl or senna. Thin layer chromatography (TLC) of urine or stool is the only commercially available test for these laxatives. Such testing is considered highly reliable, but its accuracy in clinical practice is unknown. Our aim was to evaluate the reliability of TLC laxative testing by a clinical reference laboratory in the United States. Methods: Diarrhea was induced in healthy volunteers by ingestion of bisacodyl, senna, or a c

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Christensen, Helene Nordahl, Urban Olsson, Jesper From, and Harald Breivik. "Opioid-induced constipation, use of laxatives, and health-related quality of life." Scandinavian Journal of Pain 11, no. 1 (2016): 104–10. http://dx.doi.org/10.1016/j.sjpain.2015.12.007.

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AbstractBackground and aimsReal-life data on laxative use in patients suffering from opioid-induced constipation (OIC) are very limited, and many OIC patients are only using over the counter laxatives to resolve their constipation. Our aim was to describe laxative utilization and quality of life in participants in Norway who ever experienced OIC.MethodsThis was a cross-sectional online survey conducted between 27th of June and 3rd of July 2014 among participants above 18 years with self-reported OIC and who had agreed to receive information from the pharmacy chain (Boots A/S, Norway). The ques

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Rockney, Randy. "LAXATIVES [letter]." Pediatric Annals 28, no. 7 (1999): 412. http://dx.doi.org/10.3928/0090-4481-19990701-05.

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Spiller, H. A. "Senna Laxatives." Clin-Alert 41, no. 9 (2003): 3. http://dx.doi.org/10.1177/0069477003041009004.

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Lee, Bong Eun, Tae Hee Lee, Seong-Eun Kim, et al. "Conventional Laxatives." Korean Journal of Medicine 88, no. 1 (2015): 1. http://dx.doi.org/10.3904/kjm.2015.88.1.1.

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Plotnikova, E. Yu, T. Yu Gracheva, M. N. Sinkovа, and L. K. Isakov. "The role of dietary fiber in the correction of digestion and constipation of various etiologies." Medical Council, no. 14 (October 11, 2019): 99–106. http://dx.doi.org/10.21518/2079-701x-2019-14-99-106.

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Psyllium is a predominantly soluble fiber among other natural plant-based dietary fiber used in food and pharmaceuticals and is sold as a laxative fiber. Isphagula (lat. ispaghula)– international nonproprietary name of a medicine of «psyllium». Accordingly to ATX belongs to the group of «Laxatives», subgroup «A06AC «Laxatives increasing volume of intestinal contents» (Bulking laxatives) and has the following code and name: «A06AC01 «Ispaghula» (plantain oval seeds)». Isphagula is a medical dietary fiber; in the context of gastrointestinal problems in terms of «ispaghula» and «psyllium» are syn

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Plotnikova, E. Yu, and K. A. Krasnov. "Constipation needs to be treated." Medical Council, no. 14 (October 10, 2018): 61–66. http://dx.doi.org/10.21518/2079-701x-2018-14-61-66.

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The article presents etiology, pathophysiology and epidemiology of constipation. The main groups of drugs that are used for this pathology are described in the section Treatment of Constipation. Stimulant laxatives are the most commonly demanded by the patients. The article provides the analysis of the use of sodium picosulfate in various clinical studies. Sodium picosulfate is one of the main drugs from the stimulant laxative group.

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Doyle, D. "Per rectum: a history of enemata." Journal of the Royal College of Physicians of Edinburgh 35, no. 4 (2005): 367–70. https://doi.org/10.1177/1478271520053504008.

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Enemas and clysters have been administered since before recorded history, using instruments ranging from cow horns and hollowed out bamboo shoots to metal syringes to inject laxatives, herbs, opium, turpentine, tobacco, oxygen and noxious chemicals. The potentially lethal dangers are today well recognised. The rectal route, now less often used for laxative enemas is still proving useful for other medications, increasingly in suppository form.

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Long, Yanfang, Li Li, Xi Chen, Lingyun Tian, Haiyan He, and Ying-lan Li. "Traditional laxatives in preventing opioid-induced constipation in adult patients with cancer: a systematic review and meta-analysis protocol." BMJ Open 14, no. 12 (2024): e086001. https://doi.org/10.1136/bmjopen-2024-086001.

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IntroductionOpioid-induced constipation (OIC) affects up to 90% of patients with cancer receiving long-term opioid-related analgesic therapy, resulting in various potential complications, compromised pain management and decreased quality of life. Laxatives stimulate or facilitate bowel evacuation. Traditional laxatives, such as polyethylene glycol and lactulose, are widely used because of their low cost, easy accessibility and tolerability. OIC prophylaxis with laxatives is recommended for patients receiving opioid therapy. However, systematic reviews that support this practice are lacking. Th

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Morales, M. A., D. Hernández, S. Bustamante, I. Bachiller, and A. Rojas. "Is Senna Laxative Use Associated to Cathartic Colon, Genotoxicity, or Carcinogenicity?" Journal of Toxicology 2009 (2009): 1–8. http://dx.doi.org/10.1155/2009/287247.

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Due to their natural origin, apparent low oral toxicity, effectiveness, and accessibility without a medical prescription, the anthranoid laxatives are a popular remedy for constipation and are frequently used abusively. Therefore, it is important to characterize its harmful and/or toxic effects. The sennosides, main active metabolites of senna, exhibit a very low toxicity in rats, and its genotoxic activity in bacterial strains as well as mammal cells was classified as weak in those cases where it was shown to be significant. The toxicological and mutagenic status of the crude extract of senna

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Balekuduru, Avinash, and Manoj Kumar Sahu. "Expert opinion on the habit forming properties of laxatives in patients with constipation." F1000Research 11 (July 19, 2022): 803. http://dx.doi.org/10.12688/f1000research.123407.1.

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Constipation is a commonly reported disorder in many patients. Constipation treatment using laxatives on a regular and long term basis can lead to patient dependence, especially among the elderly. However, there is scanty data on the habit-forming potential of laxatives in Indian constipated patients. This review has explored literature evidence and expert opinion on patients’ experience regarding habit-forming attributes of stimulant and osmotic laxatives. Additionally, structured face-to-face discussions were conducted with 2 key opinion leaders to understand their clinical experience on the

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Balekuduru, Avinash, and Manoj Kumar Sahu. "Habit forming properties of laxatives for chronic constipation: A review." F1000Research 11 (June 9, 2023): 803. http://dx.doi.org/10.12688/f1000research.123407.2.

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Abstract:

Constipation is a commonly reported disorder in many patients. Constipation treatment using laxatives on a regular and long term basis can lead to patient dependence, especially among the elderly. However, there is scanty data on the habit-forming potential of laxatives in Indian constipated patients. This review has explored literature evidence and expert opinion on patients’ experience regarding habit-forming attributes of stimulant and osmotic laxatives. Additionally, structured face-to-face discussions were conducted with 2 key opinion leaders to understand their clinical experience on the

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Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "Understanding the Mechanism of Action of Drugs Acting on Purgatives." Journal of Research and Reviews in Homeopathy, Siddha & Unani 1, no. 1 (2024): 17–20. https://doi.org/10.5281/zenodo.10851560.

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<em>Purgatives are termed as laxatives. Purgatives enhance bowel movements to eliminate fecal matter from the body. Bulk-forming laxatives namely psyllium and methyl cellulose show their action by enhancing the volume and water content of the stool and the passage of stool occurs through intestines via peristalsis. Osmotic laxatives such as lactulose and propylene glycol act by drawing water into the intestines. Osmotic laxatives result in constipation. stimulant laxatives such as bisacodyl and senna act by irritating the intestinal lining which results in enhanced peristalsis and increased bo

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Shin, Jeong Eun, Kyoung Sup Hong, Kee Wook Jung, et al. "Guidelines for the Use of Laxatives: Which Laxatives, When?" Korean Journal of Medicine 88, no. 1 (2015): 22. http://dx.doi.org/10.3904/kjm.2015.88.1.22.

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Matveev, I. A., S. V. Lipovoy, M. P. Kozlov, and N. N. Povarnin. "Sodium picosulfate in the clinical practice of a surgeon." Ambulatornaya khirurgiya = Ambulatory Surgery (Russia) 20, no. 2 (2023): 135–43. http://dx.doi.org/10.21518/akh2023-016.

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Picosulfate, a diphenylmethane derivative, belongs to a group of drugs called stimulant laxatives. It is widely used in surgery to treat various colon evacuation disorders due to its effectiveness, safety of use and ease of dosage selection, as well as the option to combine with other laxatives. It is administered much more frequently for colorectal cancer screening, when the colon is prepared using sodium picosulfate combined with other osmotic laxatives, most often polyethylene glycol, which allows to use smaller volumes of solution. According to the literature, this method for cleaning the

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Ибрагимова, Л. Н., М. Ж. Наурызгалиева, З. Б. Сакипова, and О. В. Сермухамедова. "ANALYSIS OF LAXATIVE DRUGS IN THE PHARMACEUTICAL MARKET OF THE REPUBLIC OF KAZAKHSTAN." Farmaciâ Kazahstana, no. 3 (July 16, 2021): 26–31. http://dx.doi.org/10.53511/pharmkaz.2021.53.45.007.

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В статье представлен обзор рынка слабительных лекарственных за 2020 г., установлены основные особенности развития данного сегмента фармацевтического рынка Казахстана. Проведен анализ слабительных препаратов по соотношению стран-производителей, лекарственных форм, цен. The article provides an overview of the market for laxative drugs for 2020 and identifies the main features of this segment of the pharmaceutical market in Kazakhstan. The analysis of laxatives according to the ratio of manufacturing countries, dosage forms, prices was carried out.

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Fattah, Areen Sarteep, and Zaher Tahir Mousheer. "Osmotic laxative versus stimulant laxative in the management of childhood functional constipation." Advanced Medical Journal 6, no. 1 (2020): 1–6. http://dx.doi.org/10.56056/amj.2020.111.

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Background and objectives: Constipation within children is an extremely common problem. The objective of this study is to evaluate and compare the efficacy and safety of osmotic and stimulant laxative used to treat functional constipation in children. Methods:This interventional clinical study was conducted between August 2018 till February 2019; at Rapareen Pediatrics Teaching Hospital, in Erbil governorate. One hundred cases, between one to five years of age, were collected. All patients were suffering from functional constipation and fulfilled 2-3 ROME IV criteria. Patients were randomly di

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Torii, Akira. "V. Osmotic Laxatives." Nihon Naika Gakkai Zasshi 108, no. 1 (2019): 36–39. http://dx.doi.org/10.2169/naika.108.36.

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Shannon, Michael, Susan S. Fish, and Frederick H. Lovejoy. "Cathartics and Laxatives." Medical Toxicology 1, no. 4 (1986): 247–52. http://dx.doi.org/10.1007/bf03259841.

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Hong, Sung Noh, Jeong Eun Shin, Kyoung Sup Hong, et al. "New Generation Laxatives." Korean Journal of Medicine 88, no. 1 (2015): 9. http://dx.doi.org/10.3904/kjm.2015.88.1.9.

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Johnson, C. D., M. Chir, J. Budd, and A. J. Ward. "Laxatives after hemorrhoidectomy." Diseases of the Colon & Rectum 30, no. 10 (1987): 780–81. http://dx.doi.org/10.1007/bf02554626.

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Hale, Martin E., James E. Wild, Tadaaki Yamada, et al. "Naldemedine is effective in the treatment of opioid-induced constipation in patients with chronic non-cancer pain who had a poor response to laxatives." Therapeutic Advances in Gastroenterology 14 (January 2021): 175628482110323. http://dx.doi.org/10.1177/17562848211032320.

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Background: Two studies demonstrated the efficacy and safety of naldemedine in adult patients with chronic non-cancer pain and opioid-induced constipation (OIC). However, no studies have compared the efficacy of peripherally acting µ-opioid receptor antagonists in patients with adequate and inadequate responses to prior OIC therapy with laxatives. This post hoc analysis of integrated data from the two previous studies compared the efficacy of naldemedine in patients who were unsuccessfully treated with laxatives [poor laxative responders (PLRs)] with those who either did not receive laxatives

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&NA;. "Combat laxative abuse by stopping stimulant laxatives and establishing healthy gastrointestinal function." Drugs & Therapy Perspectives 27, no. 3 (2011): 12–14. http://dx.doi.org/10.2165/11206580-000000000-00000.

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