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Journal articles on the topic 'Lc-hrms'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Katahira, Takehiro, Akio Kanazawa, Mai Shinohara, et al. "Postprandial Plasma Glucagon Kinetics in Type 2 Diabetes Mellitus: Comparison of Immunoassay and Mass Spectrometry." Journal of the Endocrine Society 3, no. 1 (2018): 42–51. http://dx.doi.org/10.1210/js.2018-00142.

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Abstract Context Accurate glucagon level measurements are necessary for investigation of mechanisms for postprandial hyperglycemia in type 2 diabetes. Objective To evaluate the accuracy of postprandial glucagon level measurements using a sandwich ELISA vs a recently established liquid chromatography-high resolution mass spectrometry (LC-HRMS) method in type 2 diabetes mellitus. Design and Participants Twenty patients with type 2 diabetes treated with insulin underwent a meal test before and after administration of the dipeptidyl peptidase-4 inhibitor anagliptin for 4 weeks. Blood samples were

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Sun, Yuchen, Shin-ichiro Nitta, Kosuke Saito, et al. "Development of a bioanalytical method for an antisense therapeutic using high-resolution mass spectrometry." Bioanalysis 12, no. 24 (2020): 1739–56. http://dx.doi.org/10.4155/bio-2020-0225.

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Background: Ion-pairing reverse-phase LC coupled with high-resolution mass spectrometry (IP-LC/HRMS) has gained attention in oligonucleotide therapeutic bioanalyses owing to its high sensitivity and selectivity. However, optimization and validation of IP-LC/HRMS-based methods are rare. The objective of this study is the development of a sensitive and reproducible IP-LC/HRMS-based bioanalytical method using clinically approved mipomersen as a model for antisense oligonucleotides. Materials & methods/results: Mipomersen was extracted from rat plasma using Clarity OTX SPE and quantified by IP

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Maldini, Mariateresa, Gilda D’Urso, Giordana Pagliuca, et al. "HPTLC-PCA Complementary to HRMS-PCA in the Case Study of Arbutus unedo Antioxidant Phenolic Profiling." Foods 8, no. 8 (2019): 294. http://dx.doi.org/10.3390/foods8080294.

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A comparison between High-Performance Thin-Layer Chromatography (HPTLC) analysis and Liquid Chromatography High Resolution Mass Spectrometry (LC–HRMS), coupled with Principal Component Analysis (PCA) was carried out by performing a combined metabolomics study to discriminate Arbutus unedo (A. unedo) plants. For a rapid digital record of A. unedo extracts (leaves, yellow fruit, and red fruit collected in La Maddalena and Sassari, Sardinia), HPTLC was used. Data were then analysed by PCA with the results of the ability of this technique to discriminate samples. Similarly, extracts were acquired

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Lefebvre, Donatien, Kevin Blanco-Valle, Jacques-Antoine Hennekinne, et al. "Multiplex Detection of 24 Staphylococcal Enterotoxins in Culture Supernatant Using Liquid Chromatography Coupled to High-Resolution Mass Spectrometry." Toxins 14, no. 4 (2022): 249. http://dx.doi.org/10.3390/toxins14040249.

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Staphylococcal food poisoning outbreaks are caused by the ingestion of food contaminated with staphylococcal enterotoxins (SEs). Among the 27 SEs described in the literature to date, only a few can be detected using immuno-enzymatic-based methods that are strongly dependent on the availability of antibodies. Liquid chromatography, coupled to high-resolution mass spectrometry (LC-HRMS), has, therefore, been put forward as a relevant complementary method, but only for the detection of a limited number of enterotoxins. In this work, LC-HRMS was developed for the detection and quantification of 24

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Kritmetapak, Kittrawee, Louis A. Losbanos, Jolaine M. Hines, et al. "Chemical Characterization and Quantification of Circulating Intact PTH and PTH Fragments by High-Resolution Mass Spectrometry in Chronic Renal Failure." Clinical Chemistry 67, no. 6 (2021): 843–53. http://dx.doi.org/10.1093/clinchem/hvab013.

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Abstract Background The precise concentrations of full-length parathyroid hormone (PTH1-84) and the identity and concentrations of PTH fragments in patients with various stages of chronic renal failure are unknown. Methods We developed a liquid chromatography-high resolution mass spectrometry (LC-HRMS) method to characterize and quantify PTH1-84 and PTH fragments in serum of 221 patients with progressive renal dysfunction. Following capture by matrix-bound amino-terminal or carboxyl-terminal region-specific antibodies and elution from matrix, PTH1-84 and PTH fragments were identified and quant

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Liu, Ju, Jing Li, Chris Tran, et al. "Oligonucleotide quantification and metabolite profiling by high-resolution and accurate mass spectrometry." Bioanalysis 11, no. 21 (2019): 1967–80. http://dx.doi.org/10.4155/bio-2019-0137.

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Aim: Advancements in RNA interference therapeutics have triggered development of improved bioanalytical methods for oligonucleotide metabolite profiling and high-throughput quantification in biological matrices. Results & methodology: HPLC coupled with high-resolution mass spectrometry (LC-HRMS) methods were developed to investigate the metabolism of a REVERSIR™ molecule in vivo. Plasma and tissue samples were extracted using solid-phase extraction followed by LC-HRMS analysis for metabolite profiling and quantification. The method was qualified from 10 to 5000 ng/ml (plasma) and 100 to 50

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Luo, Y. R., C. Yun, K. L. Lynch, and K. Comstock. "A High-Resolution Liquid Chromatography-Mass Spectrometry Method for Identification of Toxic Natural Products in Clinical Cases." American Journal of Clinical Pathology 154, Supplement_1 (2020): S128. http://dx.doi.org/10.1093/ajcp/aqaa161.280.

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Abstract Introduction/Objective Many natural products have biological effects on humans and animals. Poisoning caused by natural products is often found in clinical toxicology cases. Liquid chromatography-high-resolution-mass spectrometry (LC-HRMS) has recently emerged as a powerful analytical tool for large-scale target screening, and the application of LC-HRMS can be expanded to solve the clinical cases of natural product poisoning. Methods The LC-HRMS method is based on a spectral library of 121 natural products. The spectral library was constructed by analyzing standards either in a Q-TOF

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Chernonosov, Alexander, Liliya Aksenova, and Vladimir Koval. "The Development of a Liquid Chromatography High-Resolution Mass Spectrometric Method for Apixaban Quantification in Dried Plasma Spots in Parallel Reaction Monitoring Mode." Processes 9, no. 3 (2021): 450. http://dx.doi.org/10.3390/pr9030450.

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This work aimed at developing and validating a rapid, sensitive, and robust method of liquid chromatography with high-resolution mass spectrometry (LC–HRMS) in parallel reaction monitoring (PRM) mode for apixaban quantification in dried plasma spots (DPSs) with a simple extraction procedure. A 25 µL sample of human plasma was placed onto Whatman 903 Protein Saver Cards and allowed to dry; 3.2 mm diameter disks were cut out from DPSs using a puncher, and 100 µL of a working internal standard solution was added to each sample. After this, they were vortexed on a shaker for 15 min at 800 rpm and

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Wei, Cong, Louis S. Chupak, Thomas Philip, Benjamin M. Johnson, Robert Gentles, and Dieter M. Drexler. "Screening and Characterization of Reactive Compounds with In Vitro Peptide-Trapping and Liquid Chromatography/High-Resolution Accurate Mass Spectrometry." Journal of Biomolecular Screening 19, no. 2 (2013): 297–307. http://dx.doi.org/10.1177/1087057113492852.

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The present study describes a novel methodology for the detection of reactive compounds using in vitro peptide-trapping and liquid chromatography–high-resolution accurate mass spectrometry (LC-HRMS). Compounds that contain electrophilic groups can covalently bind to nucleophilic moieties in proteins and form adducts. Such adducts are thought to be associated with drug-mediated toxicity and therefore represent potential liabilities in drug discovery programs. In addition, reactive compounds identified in biological screening can be associated with data that can be misinterpreted if the reactive

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Kurniawati, Farida, Dona Fitria, Aan Risma Uli Nainggolan, and Puspita Ayu Wardani. "Identifikasi dan Karakterisasi Tanaman Kratom melalui Pendekatan Profil Kandungan Senyawa Penanda secara LC-HRMS QToF dan Penetapan Nilai Retention Index secara GCMS." Eruditio : Indonesia Journal of Food and Drug Safety 3, no. 1 (2023): 79–90. http://dx.doi.org/10.54384/eruditio.v3i1.141.

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Saat ini senyawa penanda yang diperlukan sulit diperoleh di peredaran karena termasuk senyawa dilarang di Indonesia. Penelitian ini dilakukan untuk mengembangkan alternatif metode tanpa baku pembanding dengan pendekatan profil kandungan senyawa penanda menggunakan spektrometer massa. Spektrometri massa dilakukan baik menggunakan gas kromatografi maupun liquid chromatography high resolution mass spectrometry (LC-HRMS). Kedua metode tersebut dikembangkan untuk uji konfirmasi identitas senyawa penanda pada tanaman kratom. Uji spektrometri massa dilakukan setelah senyawa penanda diekstraksi dari t

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LeBlanc, Patricia, Nadine Merkley, Krista Thomas, et al. "Isolation and Characterization of [D-Leu1]microcystin-LY from Microcystis aeruginosa CPCC-464." Toxins 12, no. 2 (2020): 77. http://dx.doi.org/10.3390/toxins12020077.

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[D-Leu1]MC-LY (1) ([M + H]+ m/z 1044.5673, Δ 2.0 ppm), a new microcystin, was isolated from Microcystis aeruginosa strain CPCC-464. The compound was characterized by 1H and 13C NMR spectroscopy, liquid chromatography–high resolution tandem mass spectrometry (LC–HRMS/MS) and UV spectroscopy. A calibration reference material was produced after quantitation by 1H NMR spectroscopy and LC with chemiluminescence nitrogen detection. The potency of 1 in a protein phosphatase 2A inhibition assay was essentially the same as for MC-LR (2). Related microcystins, [D-Leu1]MC-LR (3) ([M + H]+ m/z 1037.6041,

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Ruth, Ashley C., Connie M. Gryniewicz-Ruzicka, Michael L. Trehy, Nicole Kornspan, and Gary Coody. "Consistency of Label Claims of Internet-Purchased Hemp Oil and Cannabis Products as Determined using IMS and LC-MS : A Marketplace Survey." Journal of Regulatory Science 4, no. 3 (2016): 1–6. http://dx.doi.org/10.21423/jrs-v04n03p001.

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In this paper we describe the use of ion mobility spectrometry (IMS) and liquid chromatography – high resolution mass spectrometry (LC-HRMS) to screen for the presence of cannabinoids and other potential hazards in a set of products with hemp oil and/or cannabinoid label claims purchased via the internet. Preliminary screening was performed using IMS to examine the products for the presence of cannabinoids, illicit drugs or undeclared pharmaceuticals before analysis by LC-HRMS to quantitatively determine the presence of four of the most common naturally occurring cannabinoids while simultaneou

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Marchand, Jérémy, Yann Guitton, Estelle Martineau, et al. "Extending the Lipidome Coverage by Combining Different Mass Spectrometric Platforms: An Innovative Strategy to Answer Chemical Food Safety Issues." Foods 10, no. 6 (2021): 1218. http://dx.doi.org/10.3390/foods10061218.

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From a general public health perspective, a strategy combining non-targeted and targeted lipidomics MS-based approaches is proposed to identify disrupted patterns in serum lipidome upon growth promoter treatment in pigs. Evaluating the relative contributions of the platforms involved, the study aims at investigating the potential of innovative analytical approaches to highlight potential chemical food safety threats. Serum samples collected during an animal experiment involving control and treated pigs, whose food had been supplemented with ractopamine, were extracted and characterised using t

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Bamberger, Michelle, Marika Nell, Ahmed H. Ahmed, et al. "Surface water and groundwater analysis using aryl hydrocarbon and endocrine receptor biological assays and liquid chromatography-high resolution mass spectrometry in Susquehanna County, PA." Environmental Science: Processes & Impacts 21, no. 6 (2019): 988–98. http://dx.doi.org/10.1039/c9em00112c.

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Gören, Ahmet C., T. Cagdas Akalın, Şule Yalçın, and Ayşenur Gunaydin Akyildiz. "Determination of adulteration in hair serums by LC-HRMS §." Journal of Chemical Metrology, J (June 29, 2023): 93–99. http://dx.doi.org/10.25135/jcm.90.2304.2599.

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Slobodchikova, Irina, Reajean Sivakumar, Md Samiur Rahman, and Dajana Vuckovic. "Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography—High-Resolution Mass Spectrometry." Toxins 11, no. 8 (2019): 433. http://dx.doi.org/10.3390/toxins11080433.

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Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to measure metabolites in vivo after exposure and to establish which mycotoxin metabolites should be prioritized for the inclusion during large-scale biomonitoring efforts. The objective of this study was to perform human in vitro microsomal incubations of 17 mycotoxins and systematically characterize all resulting metabolites using liquid chroma

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Windarsih, Anjar, Nor Kartini Abu Bakar, Dachriyanus, Nancy Dewi Yuliana, Florentinus Dika Octa Riswanto, and Abdul Rohman. "Analysis of Pork in Beef Sausages Using LC-Orbitrap HRMS Untargeted Metabolomics Combined with Chemometrics for Halal Authentication Study." Molecules 28, no. 16 (2023): 5964. http://dx.doi.org/10.3390/molecules28165964.

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Beef sausage (BS) is one of the most favored meat products due to its nutrition and good taste. However, for economic purposes, BS is often adulterated with pork by unethical players. Pork consumption is strictly prohibited for religions including Islam and Judaism. Therefore, advanced detection methods are highly required to warrant the halal authenticity of BS. This research aimed to develop a liquid chromatography–high-resolution mass spectrometry (LC–HRMS) method to determine the halal authenticity of BS using an untargeted metabolomics approach. LC–HRMS was capable of detecting various me

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Aksenova, Liliya V., Vladimir V. Koval, and Alexander A. Chernonosov. "Parallel Reaction Monitoring Mode for Atenolol Quantification in Dried Plasma Spots by Liquid Chromatography Coupled with High-Resolution Mass Spectrometry." Processes 10, no. 7 (2022): 1240. http://dx.doi.org/10.3390/pr10071240.

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In this study, we reported a rapid, sensitive, robust, and validated method for atenolol quantification in dried plasma spots (DPS) by liquid chromatography with high-resolution mass spectrometry (LC-HRMS) using parallel reaction monitoring mode (PRM). Aliquots of 25 µL human plasma were placed onto Whatman 903 Cards and air-dried. Disks (3.2 mm internal diameter) were punched, and a 100 µL working internal standard solution was added to each sample and then incubated on a shaker for 15 min at 40 °C, followed by rapid centrifugation (10,000× g, 10 s). The supernatant was transferred into 300 µ

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Kryuchkov, Fedor, Alison Robertson, Elizabeth M. Mudge, Christopher O. Miles, Soetkien Van Gothem, and Silvio Uhlig. "Reductive Amination for LC–MS Signal Enhancement and Confirmation of the Presence of Caribbean Ciguatoxin-1 in Fish." Toxins 14, no. 6 (2022): 399. http://dx.doi.org/10.3390/toxins14060399.

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Ciguatera poisoning is a global health concern caused by the consumption of seafood containing ciguatoxins (CTXs). Detection of CTXs poses significant analytical challenges due to their low abundance even in highly toxic fish, the diverse and in-part unclarified structures of many CTX congeners, and the lack of reference standards. Selective detection of CTXs requires methods such as liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) or high-resolution MS (LC–HRMS). While HRMS data can provide greatly improved resolution, it is typically less sensitive than targeted LC–MS/MS

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Jiang, Meng-Ying, Yun-Qing Huang, Jie-Mei Chu, et al. "A magnetic ZrO2 based solid-phase extraction strategy for selective enrichment and profiling of glycosylated compounds in rice." Analytical Methods 8, no. 34 (2016): 6436–43. http://dx.doi.org/10.1039/c6ay01383j.

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Lucci, Paolo, Javier Saurina, and Oscar Núñez. "Trends in LC-MS and LC-HRMS analysis and characterization of polyphenols in food." TrAC Trends in Analytical Chemistry 88 (March 2017): 1–24. http://dx.doi.org/10.1016/j.trac.2016.12.006.

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Alygizakis, Nikiforos, Vasileios Konstantakos, Grigoris Bouziotopoulos, Evangelos Kormentzas, Jaroslav Slobodnik, and Nikolaos S. Thomaidis. "A Multi-Label Classifier for Predicting the Most Appropriate Instrumental Method for the Analysis of Contaminants of Emerging Concern." Metabolites 12, no. 3 (2022): 199. http://dx.doi.org/10.3390/metabo12030199.

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Liquid chromatography-high resolution mass spectrometry (LC-HRMS) and gas chromatography-high resolution mass spectrometry (GC-HRMS) have revolutionized analytical chemistry among many other disciplines. These advanced instrumentations allow to theoretically capture the whole chemical universe that is contained in samples, giving unimaginable opportunities to the scientific community. Laboratories equipped with these instruments produce a lot of data daily that can be digitally archived. Digital storage of data opens up the opportunity for retrospective suspect screening investigations for the

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Lotfy, Momen M., Ahmed M. Sayed, Asmaa M. AboulMagd, et al. "Metabolomic profiling, biological evaluation of Aspergillus awamori, the river Nile-derived fungus using epigenetic and OSMAC approaches." RSC Advances 11, no. 12 (2021): 6709–19. http://dx.doi.org/10.1039/d0ra07578g.

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Flores, Cintia, and Josep Caixach. "High Levels of Anabaenopeptins Detected in a Cyanobacteria Bloom from N.E. Spanish Sau-Susqueda-El Pasteral Reservoirs System by LC–HRMS." Toxins 12, no. 9 (2020): 541. http://dx.doi.org/10.3390/toxins12090541.

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The appearance of a bloom of cyanobacteria in the Sau-Susqueda-El Pasteral system (River Ter, NE Spain) in the autumn of 2015 has been the most recent episode of extensive bloom detected in Catalonia. This system is devoted mainly to urban supply, regulation of the river, irrigation and production of hydroelectric energy. In fact, it is one of the main supply systems for the metropolitan area of cities such as Barcelona and Girona. An assessment and management plan was implemented in order to minimize the risk associated to cyanobacteria. The reservoir was confined and periodic sampling was ca

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Chang, Wei, Genye He, Kuan Yan, et al. "Doping control analysis of small peptides in human urine using LC-HRMS with parallel reaction monitoring mode: screening and confirmation." Analytical Methods 13, no. 48 (2021): 5838–50. http://dx.doi.org/10.1039/d1ay01677f.

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This study described a reliable analytical method, which combines solid-phase extraction with LC-HRMS employing the parallel reaction monitoring mode, for screening and confirming small peptides in human urine.

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Qu, Lihua, Wenjun Wang, Debin Zeng, Yaxin Lu, and Zheng Yin. "Quantitative performance of online SPE-LC coupled to Q-Exactive for the analysis of sofosbuvir in human plasma." RSC Advances 5, no. 119 (2015): 98269–77. http://dx.doi.org/10.1039/c5ra20233g.

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Hemmer, Selina, Sascha K. Manier, Svenja Fischmann, Folker Westphal, Lea Wagmann, and Markus R. Meyer. "Comparison of Three Untargeted Data Processing Workflows for Evaluating LC-HRMS Metabolomics Data." Metabolites 10, no. 9 (2020): 378. http://dx.doi.org/10.3390/metabo10090378.

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The evaluation of liquid chromatography high-resolution mass spectrometry (LC-HRMS) raw data is a crucial step in untargeted metabolomics studies to minimize false positive findings. A variety of commercial or open source software solutions are available for such data processing. This study aims to compare three different data processing workflows (Compound Discoverer 3.1, XCMS Online combined with MetaboAnalyst 4.0, and a manually programmed tool using R) to investigate LC-HRMS data of an untargeted metabolomics study. Simple but highly standardized datasets for evaluation were prepared by in

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Mantzourani, Christiana, and Maroula G. Kokotou. "Targeted and Suspect Fatty Acid Profiling of Royal Jelly by Liquid Chromatography—High Resolution Mass Spectrometry." Biomolecules 13, no. 3 (2023): 424. http://dx.doi.org/10.3390/biom13030424.

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Royal jelly (RJ) is a bee product produced by the mandibular and hypopharyngeal glands of worker honeybees which has attracted special attention because of its numerous pharmacological activities and its applications to dermatology and cosmetics. In 2020, we demonstrated a liquid chromatography–high resolution mass spectrometry (LC–HRMS) method for the determination of seven medium-chain FFAs in RJ samples. The aim of the present work was to extend our studies on FA profiling of RJ, exploring the presence of common long-chain saturated, mono-unsaturated and poly-unsaturated free FAs in RJ samp

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Windarsih, Anjar, Florentinus Dika Octa Riswanto, Nor Kartini Abu Bakar, Nancy Dewi Yuliana, Dachriyanus, and Abdul Rohman. "Detection of Pork in Beef Meatballs Using LC-HRMS Based Untargeted Metabolomics and Chemometrics for Halal Authentication." Molecules 27, no. 23 (2022): 8325. http://dx.doi.org/10.3390/molecules27238325.

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Adulteration of high-quality meat products using lower-priced meats, such as pork, is a crucial issue that could harm consumers. The consumption of pork is strictly forbidden in certain religions, such as Islam and Judaism. Therefore, the objective of this research was to develop untargeted metabolomics using liquid chromatography-high resolution mass spectrometry (LC-HRMS) combined with chemometrics for analysis of pork in beef meatballs for halal authentication. We investigated the use of non-targeted LC-HRMS as a method to detect such food adulteration. As a proof of concept using six techn

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Lin, Xiao, Ling Chai, Hong Rui Zhu, et al. "Applying molecular networking for targeted isolation of depsipeptides." RSC Advances 11, no. 5 (2021): 2774–82. http://dx.doi.org/10.1039/d0ra09388b.

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Sasse, Michael, and Matthias Rainer. "Mass Spectrometric Methods for Non-Targeted Screening of Metabolites: A Future Perspective for the Identification of Unknown Compounds in Plant Extracts." Separations 9, no. 12 (2022): 415. http://dx.doi.org/10.3390/separations9120415.

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Phyto products are widely used in natural products, such as medicines, cosmetics or as so-called “superfoods”. However, the exact metabolite composition of these products is still unknown, due to the time-consuming process of metabolite identification. Non-target screening by LC-HRMS/MS could be a technique to overcome these problems with its capacity to identify compounds based on their retention time, accurate mass and fragmentation pattern. In particular, the use of computational tools, such as deconvolution algorithms, retention time prediction, in silico fragmentation and sophisticated se

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You, Youwen, Rachel M. Proctor, Kevin Guo, et al. "Use of high resolution/accurate mass full scan/data-dependent acquisition for targeted/non-targeted screening in equine doping control." Analytical Methods 13, no. 13 (2021): 1565–75. http://dx.doi.org/10.1039/d0ay02297g.

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A targeted/non-targeted LC-HRMS/MS method for equine doping screening analysis was developed using a QE-Plus Orbitrap mass spectrometer combined with an in-house built compound database and spectral library.

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Verougstraete, Nick, and Alain Verstraete. "Identification of etazene metabolites in human urine by LC-HRMS." Toxicologie Analytique et Clinique 34, no. 3 (2022): S60. http://dx.doi.org/10.1016/j.toxac.2022.06.076.

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Vargas-Medina, Lorena, Lydia F. Yamaguchi, and Ericsson Coy-Barrera. "LC-ESI-HRMS-Based Chemical Characterization of Lupinus bogotensis Roots." Revista Facultad de Ciencias Básicas 12, no. 2 (2016): 200–211. http://dx.doi.org/10.18359/rfcb.2028.

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Plants of the genus Lupinus (Fabaceae) have been studied due to the occurrence of different compounds, especially those possessing quinolizidine and isoflavone-like structures. These kinds of compounds are characterized by both medical and industrial applications, providing various benefits to human being. However, organs such as roots have not been equally studied and there is a lack of such records for native species. Therefore, in the present study, the chemical composition of nodulated roots from greenhouse-established L. bogotensis plants was determined. The resulting crude ethanolic extr

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Kunzelmann, Marco, Martin Winter, Magnus Åberg, Karl-Erik Hellenäs, and Johan Rosén. "Non-targeted analysis of unexpected food contaminants using LC-HRMS." Analytical and Bioanalytical Chemistry 410, no. 22 (2018): 5593–602. http://dx.doi.org/10.1007/s00216-018-1028-4.

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Olesti, Eulalia, Arnaud Garcia, Rita Rahban, et al. "Steroid profile analysis by LC-HRMS in human seminal fluid." Journal of Chromatography B 1136 (January 2020): 121929. http://dx.doi.org/10.1016/j.jchromb.2019.121929.

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Qiu, Jiangbing, Elliott J. Wright, Krista Thomas, Aifeng Li, Pearse McCarron, and Daniel G. Beach. "Semiquantitation of Paralytic Shellfish Toxins by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry Using Relative Molar Response Factors." Toxins 12, no. 6 (2020): 398. http://dx.doi.org/10.3390/toxins12060398.

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Paralytic shellfish toxins (PSTs) are a complex class of analogs of the potent neurotoxin saxitoxin (STX). Since calibration standards are not available for many PSTs, including C-11 hydroxyl analogs called M-toxins, accurate quantitation by liquid chromatography–mass spectrometry (LC-MS) can be challenging. In the absence of standards, PSTs are often semiquantitated using standards of a different analog (e.g., STX), an approach with a high degree of uncertainty due to the highly variable sensitivity between analytes in electrospray ionization. Here, relative molar response factors (RMRs) were

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Albergamo, Vittorio, Beate I. Escher, Emma L. Schymanski, et al. "Evaluation of reverse osmosis drinking water treatment of riverbank filtrate using bioanalytical tools and non-target screening." Environmental Science: Water Research & Technology 6, no. 1 (2020): 103–16. http://dx.doi.org/10.1039/c9ew00741e.

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Organic micropollutants that occurred in a natural drinking water source induced effects that were not detectable after reverse osmosis. Bioactive compounds were characterised by non-target screening of LC-HRMS data using open cheminformatics approaches.

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Haiß, Annette, Andrew Jordan, Janin Westphal, Evgenia Logunova, Nicholas Gathergood, and Klaus Kümmerer. "On the way to greener ionic liquids: identification of a fully mineralizable phenylalanine-based ionic liquid." Green Chemistry 18, no. 16 (2016): 4361–73. http://dx.doi.org/10.1039/c6gc00417b.

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Biodegradability screening ofl-phenylalanine based ILs and LC-HRMS analysis of the degradation products led to the identification of a pyridinium IL which was fully mineralizable and is proposed as a basic structure for green ILs.

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D'Urso, Gilda, Assunta Napolitano, Ciro Cannavacciuolo, Milena Masullo, and Sonia Piacente. "Okra fruit: LC-ESI/LTQOrbitrap/MS/MSn based deep insight on polar lipids and specialized metabolites with evaluation of anti-oxidant and anti-hyperglycemic activity." Food & Function 11, no. 9 (2020): 7856–65. http://dx.doi.org/10.1039/d0fo00867b.

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The chemical composition of okra fruit was analysed by LC-HRMS. Metabolites belonging to different polar lipid classes, along with phenolic acids and flavonoids were identified. The antioxidant activity and inhibition of α-glucosidase were assayed.

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Klijnstra, Mirjam, and Arjen Gerssen. "A Sensitive LC-MS/MS Method for Palytoxin Using Lithium Cationization." Toxins 10, no. 12 (2018): 537. http://dx.doi.org/10.3390/toxins10120537.

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Palytoxin (PlTX) and analogues are produced by certain dinoflagellates, sea anemones, corals and cyanobacteria. PlTX can accumulate in the food chain and when consumed it may cause intoxication with symptoms like myalgia, weakness, fever, nausea, and vomiting. The analysis of PlTXs is challenging, and because of the large molecular structure, it is difficult to develop a sensitive and selective liquid chromatography-mass spectrometry (LC-MS/MS) method. In this work, an LC-MS/MS method was developed to analyse PlTXs with use of lithium iodine and formic acid as additives in the mobile phase. Fo

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Ramadhan, Muhammad Fajri, Endang Astuti, and Respati Tri Swasono. "Screening and Toxicity Assay of Bioactive Compounds from Ethyl Acetate Extract of Indonesian Marine Sponge <i>Dysidia </i>sp<i>.</i> from Hoga Island." Materials Science Forum 1061 (May 26, 2022): 165–71. http://dx.doi.org/10.4028/p-rg4242.

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Screening of the toxic active compounds from the ethyl acetate fraction of the sponge Dysidea sp. from Hoga Island, Wakatobi National Park. This study aims to determine the toxic properties of the ethyl acetate fraction of sponge Dysidea sp. Isolation was carried out by extraction method using methanol as solvent, then the extract was partitioned using various solvents, such as N-Hexane, Dichloromethane, Ethyl Acetate and Acetone. The obtained fraction was then tested for toxicity using the Brine Shrimp Lethality Test (BSLT) and phytochemical tests. Identification of compounds from the fractio

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Estevez, Pablo, Manoella Sibat, José Manuel Leão-Martins, Pedro Reis Costa, Ana Gago-Martínez, and Philipp Hess. "Liquid Chromatography Coupled to High-Resolution Mass Spectrometry for the Confirmation of Caribbean Ciguatoxin-1 as the Main Toxin Responsible for Ciguatera Poisoning Caused by Fish from European Atlantic Coasts." Toxins 12, no. 4 (2020): 267. http://dx.doi.org/10.3390/toxins12040267.

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Ciguatera poisoning (CP) is a common seafood intoxication mainly caused by the consumption of fish contaminated by ciguatoxins. Recent studies showed that Caribbean ciguatoxin-1 (C-CTX1) is the main toxin causing CP through fish caught in the Northeast Atlantic, e.g., Canary Islands (Spain) and Madeira (Portugal). The use of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) combined with neuroblastoma cell assay (N2a) allowed the initial confirmation of the presence of C-CTX1 in contaminated fish samples from the abovementioned areas, nevertheless the lack of commercially av

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Kotapati, Srikanth, Madhura Deshpande, Aarti Jashnani, Dharam Thakkar, Hongwu Xu, and Gavin Dollinger. "The role of ligand-binding assay and LC–MS in the bioanalysis of complex protein and oligonucleotide therapeutics." Bioanalysis 13, no. 11 (2021): 931–54. http://dx.doi.org/10.4155/bio-2021-0009.

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Ligand-binding assay (LBA) and LC–MS have been the preferred bioanalytical techniques for the quantitation and biotransformation assessment of various therapeutic modalities. This review provides an overview of the applications of LBA, LC–MS/MS and LC–HRMS for the bioanalysis of complex protein therapeutics including antibody–drug conjugates, fusion proteins and PEGylated proteins as well as oligonucleotide therapeutics. The strengths and limitations of LBA and LC–MS, along with some guidelines on the choice of appropriate bioanalytical technique(s) for the bioanalysis of these therapeutic mod

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Kintz, Pascal, Alice Ameline, Laurie Gheddar, and Jean‐Sébastien Raul. "Testing for GW501516 (cardarine) in human hair using LC/MS–MS and confirmation by LC/HRMS." Drug Testing and Analysis 12, no. 7 (2020): 980–86. http://dx.doi.org/10.1002/dta.2802.

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Millet, Aurélien, Nihel Khoudour, Dorothée Lebert, et al. "Development, Validation, and Comparison of Two Mass Spectrometry Methods (LC-MS/HRMS and LC-MS/MS) for the Quantification of Rituximab in Human Plasma." Molecules 26, no. 5 (2021): 1383. http://dx.doi.org/10.3390/molecules26051383.

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Rituximab is a chimeric immunoglobulin G1-kappa (IgG1κ) antibody targeting the CD20 antigen on B-lymphocytes. Its applications are various, such as for the treatment of chronic lymphoid leukemia or non-Hodgkin’s lymphoma in oncology, and it can also be used in the treatment of certain autoimmune diseases. Several studies support the interest in therapeutic drug monitoring to optimize dosing regimens of rituximab. Thus, two different laboratories have developed accurate and reproductive methods to quantify rituximab in human plasma: one using liquid chromatography quadripolar tandem mass spectr

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Malm, Louise, Emma Palm, Amina Souihi, Merle Plassmann, Jaanus Liigand, and Anneli Kruve. "Guide to Semi-Quantitative Non-Targeted Screening Using LC/ESI/HRMS." Molecules 26, no. 12 (2021): 3524. http://dx.doi.org/10.3390/molecules26123524.

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Non-targeted screening (NTS) with reversed phase liquid chromatography electrospray ionization high resolution mass spectrometry (LC/ESI/HRMS) is increasingly employed as an alternative to targeted analysis; however, it is not possible to quantify all compounds found in a sample with analytical standards. As an alternative, semi-quantification strategies are, or at least should be, used to estimate the concentrations of the unknown compounds before final decision making. All steps in the analytical chain, from sample preparation to ionization conditions and data processing can influence the si

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van Herwerden, Denice, Jake W. O'Brien, Phil M. Choi, Kevin V. Thomas, Peter J. Schoenmakers, and Saer Samanipour. "Naive Bayes classification model for isotopologue detection in LC-HRMS data." Chemometrics and Intelligent Laboratory Systems 223 (April 2022): 104515. http://dx.doi.org/10.1016/j.chemolab.2022.104515.

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Narduzzi, Luca, Anne-Lise Royer, Emmanuelle Bichon, et al. "Ammonium Fluoride as Suitable Additive for HILIC-Based LC-HRMS Metabolomics." Metabolites 9, no. 12 (2019): 292. http://dx.doi.org/10.3390/metabo9120292.

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Hydrophilic Interaction Liquid Chromatography (HILIC) chromatography is widely applied in metabolomics as a complementary strategy to reverse phase chromatography. Nevertheless, it still faces several issues in terms of peak shape and compounds ionization, limiting the automatic de-convolution and data semi-quantification performed through dedicated software. A way to improve the chromatographic and ionization performance of a HILIC method is to modify the electrostatic interactions of the analytes with both mobile and stationary phases. In this study, using a ZIC-HILIC chromatographic phase,

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Vrobel, Ivo, David Friedecký, Edgar Faber, et al. "Novel sulphur-containing imatinib metabolites found by untargeted LC-HRMS analysis." European Journal of Pharmaceutical Sciences 104 (June 2017): 335–43. http://dx.doi.org/10.1016/j.ejps.2017.04.014.

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