Relevant bibliographies by topics / LC-MS/MS bioanalysis

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'LC-MS/MS bioanalysis'

Author: Grafiati
Published: 4 June 2025
Last updated: 15 July 2025

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Journal articles on the topic "LC-MS/MS bioanalysis"

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Arnold, Don W., and Shane R. Needham. "Micro-LC–MS/MS: the future of bioanalysis." Bioanalysis 5, no. 11 (2013): 1329–31. http://dx.doi.org/10.4155/bio.13.31.

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Jemal, Mohammed. "High-throughput quantitative bioanalysis by LC/MS/MS." Biomedical Chromatography 14, no. 6 (2000): 422–29. http://dx.doi.org/10.1002/1099-0801(200010)14:6<422::aid-bmc25>3.0.co;2-i.

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Li, Xiaotong, Yuanqiang Su, Xinxin Wen, et al. "Rapid adenosine bioanalysis with LS-LC-MS/MS." Drug Metabolism and Pharmacokinetics 61 (June 2025): 101211. https://doi.org/10.1016/j.dmpk.2025.101211.

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Deng, Pan, Yan Zhan, Xiaoyan Chen, and Dafang Zhong. "Derivatization methods for quantitative bioanalysis by LC–MS/MS." Bioanalysis 4, no. 1 (2012): 49–69. http://dx.doi.org/10.4155/bio.11.298.

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Bergeron, Annik, and Fabio Garofolo. "Importance of matrix effects in LC–MS/MS bioanalysis." Bioanalysis 5, no. 19 (2013): 2331–32. http://dx.doi.org/10.4155/bio.13.237.

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van Dongen, William D., and Wilfried MA Niessen. "LC–MS systems for quantitative bioanalysis." Bioanalysis 4, no. 19 (2012): 2391–99. http://dx.doi.org/10.4155/bio.12.221.

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Glaser, Vicki. "Optimizing LC/MS for Drug Bioanalysis." Genetic Engineering & Biotechnology News 32, no. 5 (2012): 1–27. http://dx.doi.org/10.1089/gen.32.5.09.

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Kotapati, Srikanth, Madhura Deshpande, Aarti Jashnani, Dharam Thakkar, Hongwu Xu, and Gavin Dollinger. "The role of ligand-binding assay and LC–MS in the bioanalysis of complex protein and oligonucleotide therapeutics." Bioanalysis 13, no. 11 (2021): 931–54. http://dx.doi.org/10.4155/bio-2021-0009.

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Ligand-binding assay (LBA) and LC–MS have been the preferred bioanalytical techniques for the quantitation and biotransformation assessment of various therapeutic modalities. This review provides an overview of the applications of LBA, LC–MS/MS and LC–HRMS for the bioanalysis of complex protein therapeutics including antibody–drug conjugates, fusion proteins and PEGylated proteins as well as oligonucleotide therapeutics. The strengths and limitations of LBA and LC–MS, along with some guidelines on the choice of appropriate bioanalytical technique(s) for the bioanalysis of these therapeutic mod
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Zhang, Zhengqi, Yuetian Yan, Shunhai Wang, and Ning Li. "Development of a chromatography-free method for high-throughput MS-based bioanalysis of therapeutic monoclonal antibodies." Bioanalysis 13, no. 9 (2021): 725–35. http://dx.doi.org/10.4155/bio-2021-0021.

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Aim: Our objective was to test the feasibility of developing an LC-free, MS-based approach for high-throughput bioanalysis of humanized therapeutic monoclonal antibodies. Methodology: A universal tryptic peptide from human IgG1, IgG3 and IgG4 was selected as the surrogate peptide for quantitation. After tryptic digestion, the surrogate peptide was fractionated via solid-phase extraction before being subjected to direct infusion-based MS/MS analysis. A high-resolution, multiplexed (MSX = 2) parallel reaction monitoring method was developed for data acquisition. Results &amp; conclusion: This pr
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Liu, Aowen, Ming Cheng, Yixuan Zhou, and Pan Deng. "Bioanalysis of Oligonucleotide by LC–MS: Effects of Ion Pairing Regents and Recent Advances in Ion-Pairing-Free Analytical Strategies." International Journal of Molecular Sciences 23, no. 24 (2022): 15474. http://dx.doi.org/10.3390/ijms232415474.

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Oligonucleotides (OGNs) are relatively new modalities that offer unique opportunities to expand the therapeutic targets. Reliable and high-throughput bioanalytical methods are pivotal for preclinical and clinical investigations of therapeutic OGNs. Liquid chromatography–mass spectrometry (LC–MS) is now evolving into being the method of choice for the bioanalysis of OGNs. Ion paring reversed-phase liquid chromatography (IP-RPLC) has been widely used in sample preparation and LC–MS analysis of OGNs; however, there are technical issues associated with these methods. IP-free methods, such as hydro
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Dissertations / Theses on the topic "LC-MS/MS bioanalysis"

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Brown, Stacy D., and J. Carmichael. "Phospholipid Depletion Techniques in LC-MS Bioanalysis." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7850.

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Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthca
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Bianchi, Michele. "LC-MS applications in Pharmaceutical Analysis, Bioanalysis and Proteomics." Doctoral thesis, Università del Piemonte Orientale, 2019. http://hdl.handle.net/11579/102458.

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Liquid Chromatography tandem Mass Spectrometry (LC-MS) is a powerful tool available to scientists with multidisciplinary applications. In this thesis, LC-MS technique had a key role to perform exciting experiments giving back an outstanding contribute to each project caught up. Different LC-MS instruments were involved. We worked with HPLC and UHPLC systems operating with micro- or nano-flow rates. At the same time, various MS analyzers working in different scan modes (full MS, MS2, MS3, SRM, MRM and DDA) were chosen depending by the expected results. The projects addressed by this thesis were
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Nascimento, DemÃtrius Fernandes do. "Nimodipine determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS-MS)." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=31.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A rapid, specific and highly sensitive liquid chromatography-tandem mass spectrometry method was developed to determine nimodipine in human plasma using dibucaine as the internal standard (IS) is described. The analyte (m/z 418,6 > 342,6) and IS (m/z 344,2 > 271,0) were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1v/v). Chromatography was performed on a Varian Polaris C18 analytical column (3 micrometer, 50 x 2,0 mm) and pre-column SecurityguardTM C18 (4,0 x 3,0 mm). The phase mobile c
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Chambers, Erin. "Improving the sensitivity and specificity of LC/MS to enable bioanalysis of therapeutic and endogenous proteins and peptides." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/improving-the-sensitivity-and-specificity-of-lcms-to-enable-bioanalysis-of-therapeutic-and-endogenous-proteins-and-peptides(06b872cd-02df-4afa-8a8c-793cbd209e32).html.

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This thesis establishes LC/MS as a viable, robust, and attractive alternative analytical platform to ligand binding assays for the quantification of therapeutic and endogenous peptides/proteins in biological fluids. A rigorous investigation of the parameters that affect assay sensitivity, specificity and robustness revealed that a careful combination of mixed-mode solid phase extraction, reversed-phase liquid chromatography utilizing sub 2μm charged surface solid core stationary phases, coupled to tandem quadrupole mass spectrometry can deliver a generic platform for assay development. By exte
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Howard, James W. "The development of mass spectrometry-based methodologies for the high throughput quantitation of peptides in biological matrices." Thesis, Loughborough University, 2018. https://dspace.lboro.ac.uk/2134/32454.

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The aim of this research was the development of mass spectrometry-based methodologies for the high-throughput quantitation of peptides in biological matrices. Glucagon and GLP-1, which are of interest as biomarkers and in the development of therapeutics, were chosen as model peptides. Immunoassays that are traditionally used to quantify these often perform poorly; therefore, necessitating the development of alternative methodologies. Application of mass spectrometry-based methodologies to these analytes has, however, been limited, primarily due to sensitivity challenges, but also due to analyt
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Shah, Kumar. "Quantitative Analysis of Tobacco Specific Nitrosamine in Human Urine Using Molecularly Imprinted Polymers as a Potential Tool for Cancer Risk Assessment." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1954.

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Measuring urinary tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide conjugate may provide the best biomarker of tobacco smoke lung carcinogen metabolism. Existence of differences in the extent of NNAL metabolism rates may be potentially related to an individuals’ lung cancer susceptibility. Low concentrations of NNAL in smokers urine (<1 ng/mL) require sensitive and selective methods for analysis. Traditionally, this involves extensive, time-consuming sample preparation that limits throughput and adds to measurement variability. Molecularly i
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JAIN, LOKESH. "IDENTIFICATION OF CLINICAL, LABORATORY AND GENETIC COVARIATES FOR PHARMACOKINETICS, EFFICACY AND TOXICITY OF SORAFENIB IN PATIENTS WITH SOLID TUMORS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1973.

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The goal of this research work was to understand the clinical-pharmacology based treatment approaches for sorafenib. Treatment with sorafenib is associated with high inter-patient variability in pharmacokinetic exposures, efficacy and toxicity. We explored the demographic, laboratory, clinical and pharmacogenetic factors to elucidate the sources of variability. In addition, we examined the impact of pharmacogenetic variation in VEGFR2, an important mediator of the VEGF pathway, on risk of prostate cancer. To support these investigations, (mainly single-dose) pharmacokinetic, pharmacogene
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ZORZOLI, MARIA CHIARA. "AUTOMATION OF SAMPLE PRAPARATION IN BIOANALYTICS FOR HIGH-THROUGHPUT, ACCURATE LC-MS/MS ANALYSIS AND LABORATORY INFORMATION MANAGEMENT SYSTEM." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150037.

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Developing high-capacity sample preparation systems and strategies are of key importance in providing breakthrough in the time required to develop a drug by increasing the number/time of analyzed samples. This objective must be achieved without loosing quality within the obtained data and it is of paramount importance in Pharmacokinetic/dynamic studies. The aim of this PhD project in Analytical Chemistry is to automize the manual sample preparation processes for LC/MS analysis using high throughput techniques, and to insert the developed process in the frame of a pharmaceutical bioanalytical p
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Fan, Bin. "Pharmaceutical analysis of the prodrug metronidazole benzoate ; bioanalysis of anti-HIV drugs in human serum using HPLC, CE, LC-MS-MS." 2001. http://purl.galileo.usg.edu/uga%5Fetd/fan%5Fbin%5F200112%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2001.<br>Directed by James T. Stewart. Includes an article published in International journal of pharmaceutical compounding, articles submitted to Drug development and industrial pharmacy, Journal of pharmaceutical and biomedical analysis, Biomedical chromatography, Journal of capillary electrophoresis, Journal of liquid chromatography & related technologies, and Veterinary anaesthesia and analgesia, and an article accepted by Journal of liquid chromatography & ralated technologies. Includes bibliographical references.
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Books on the topic "LC-MS/MS bioanalysis"

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Xu, Q. Alan, and Timothy L. Madden, eds. LC-MS in Drug Bioanalysis. Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-3828-1.

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Li, Wenkui, Jie Zhang, and Francis L. S. Tse, eds. Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.

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L, Madden Timothy, and SpringerLink (Online service), eds. LC-MS in Drug Bioanalysis. Springer US, 2012.

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Xu, Q. Alan, and Timothy L. Madden. LC-MS in Drug Bioanalysis. Springer, 2014.

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Xu, Q. Alan, and Timothy L. Madden. LC-MS in Drug Bioanalysis. Springer, 2012.

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Li, Wenkui, Wenying Jian, and Yunlin Fu. Sample Preparation in LC-MS Bioanalysis. Wiley & Sons, Limited, John, 2019.

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Li, Wenkui, Wenying Jian, and Yunlin Fu, eds. Sample Preparation in LC‐MS Bioanalysis. Wiley, 2019. http://dx.doi.org/10.1002/9781119274315.

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Li, Wenkui, Wenying Jian, and Yunlin Fu. Sample Preparation in LC-MS Bioanalysis. Wiley & Sons, Incorporated, John, 2019.

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Li, Wenkui, Wenying Jian, and Yunlin Fu. Sample Preparation in LC-MS Bioanalysis. Wiley & Sons, Incorporated, John, 2019.

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Sample Preparation in LC-MS Bioanalysis. Wiley, 2019.

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Book chapters on the topic "LC-MS/MS bioanalysis"

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Bruins, A. P. "LC-MS and LC-MS-MS for Biomedical Analyses." In Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-9424-3_48.

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Santa, Tomofumi. "Derivatization in LC-MS Bioanalysis." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch19.

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Tweed, Joseph A. "Automation in LC-MS Bioanalysis." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch22.

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Hoffman, David. "LC-MS Bioanalysis-Related Statistics." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch32.

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Wang, Laixin, and Min Meng. "LC-MS Bioanalysis of Nucleosides." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch43.

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Cohen, Sabine, Marie-Claude Gagnieu, Isabelle Lefebvre, and Jérôme Guitton. "LC-MS Bioanalysis of Nucleotides." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch44.

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Zhang, Jie, and Frank Z. Stanczyk. "LC-MS Bioanalysis of Steroids." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch45.

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Yang, Ziping, Wenkui Li, Harold T. Smith, and Francis L. S. Tse. "LC-MS Bioanalysis of Proteins." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch47.

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Bartlett, Michael G., Buyun Chen, and A. Cary McGinnis. "LC-MS Bioanalysis of Oligonucleotides." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch48.

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Seger, Christoph, and Michael Vogeser. "Pitfalls of LC-MS/MS in the Clinical Laboratory." In LC-MS in Drug Bioanalysis. Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-3828-1_5.

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Conference papers on the topic "LC-MS/MS bioanalysis"

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Soares, MO, FP Mazete, DR Ramadan, S. Tufik, and EK Sugawara. "DESENVOLVIMENTO E VALIDAÇÃO DE MÉTODO ANALÍTICO PARA QUANTIFICAÇÃO DE VITAMINA E EM SORO POR LC-MS/MS." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.6720.

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Objetivo: O objetivo deste estudo foi desenvolver e validar um método de preparação fácil e rápida para a análise de α-tocoferol. Método: Foi utilizado cromatógrafo líquido acoplado a espectrometria de massas, modelo XEVO TQS micro (LC-MS/MS) Waters. Foram monitorados os íons exclusivos do α-tocoferol, íons quantificadores 431,4 &gt; 165,1 e íons qualificadores 431,4 &gt; 83. Para o preparo das amostras, utilizaram-se 50 µl de soro, seguidos por extração líquido-líquido. O eluato foi submetido à evaporação sob fluxo de nitrogênio e, após ressuspensão, foi injetado 1 µl no sistema; em seguida,
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