Relevant bibliographies by topics / LC-MS/MS method validation

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'LC-MS/MS method validation'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "LC-MS/MS method validation"

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Wang, Meng, Wen Jia Zhou, Quan Ying Zhang, and Ming Huang. "Development and Validation of a LC–MS/MS Method." Advanced Materials Research 722 (July 2013): 255–59. http://dx.doi.org/10.4028/www.scientific.net/amr.722.255.

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A simple, sensitive, selective, rapid, reproducible and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the identification and quantification of paroxetine (PAX) in human plasma,. Chromatographic separation was performed on XTerra RP18 (5 μm, 150 mm × 4.6 mm i.d.) column with mobile phase composed of 10 mM ammonium acetate containing 0.2% formic acid: methanol (30:70, v/v) at flow rate of 0.9 mL min-1. PAX and CZP were detected with proton adducts at m/z (amu) 330.1 192.1 and 327.2 270.1, in multiple reaction monitoring (MRM) positive mode. The method was validated over the concentration range of 0.05 - 30 ng mL-1. The lower limit of quantification (LLOQ) was 0.05 ng mL-1. The inter-run and intra-run precision was within 2.1-11.8% and 2.2-5.8%, respectively
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Kim, Yunjeong, Song-Hee Han, Ji-Young Jeon, Min-Ho Hwang, Yong-Jin Im, Sun Young Lee, Soo-Wan Chae, and Min-Gul Kim. "Validation of LC-MS/MS method for determination of ginsenoside Rg1 in human plasma." Analytical Science and Technology 26, no. 4 (August 25, 2013): 221–27. http://dx.doi.org/10.5806/ast.2013.26.4.221.

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Iram, Farah, Huma Iram, Mohd Arif, A. A. Siddiqui, and Asif Husain. "Bioanalytical Method Development and Validation by Hyphenated Technique (LC-MS/MS)." Journal of Pharmaceutical and Medicinal Chemistry 2, no. 1 (2016): 11–26. http://dx.doi.org/10.21088/jpmc.2395.6615.2116.2.

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Yang, Lufang, Gordon Ball, and Gordon Hoag. "Validation of a LC–MS/MS method for urinary free cortisol." Clinical Biochemistry 48, no. 15 (October 2015): 1014. http://dx.doi.org/10.1016/j.clinbiochem.2015.07.059.

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Kwak, Eun-Young. "Method validation of heterocyclic amines in fish with LC-MS/MS." Drug Metabolism and Pharmacokinetics 32, no. 1 (January 2017): S29. http://dx.doi.org/10.1016/j.dmpk.2016.10.134.

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Kim, Yun-Jeong, Song-Hee Han, Ji-Young Jeon, Min-Ho Hwang, Yong-Jin Im, Soo-Wan Chae, and Min-Gul Kim. "Validation of LC-MS/MS method for determination of ertapenem in human plasma and urine." Analytical Science and Technology 25, no. 1 (February 25, 2012): 19–24. http://dx.doi.org/10.5806/ast.2012.25.1.019.

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Erdoğar, Nazlı, Tuba Reçber, Alper B. İskit, Erem Bilensoy, Sedef Kır, and Emirhan Nemutlu. "Determination and validation of aprepitant in rat plasma using LC−MS/MS." Bioanalysis 13, no. 5 (March 2021): 363–72. http://dx.doi.org/10.4155/bio-2020-0293.

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Aim: The assessment of efficacy should be paralleled with extensive pharmacokinetic parameters, and a valid bioanalytical method is a pre-condition for accurate plasma concentration. Materials & methods: A simple, specific, rapid and sensitive LC−MS/MS method has been developed for quantitative analysis of aprepitant in rat plasma. A C18 column was used as stationary phase and the mobile phase consisted of a mixture of formic acid in water and formic acid in acetonitrile. Quantification was performed using multiple reaction monitoring mode. Results: The selectivity, linearity, accuracy, precision, robustness and ruggedness of the method were evaluated in accordance with bioanalytical method validation guideline of ICH and all results were within the acceptable range. Conclusion: The validated LC−MS/MS method was found to be useful for the quantitative analysis of aprepitant in rat plasma samples.
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L. Pithiya, Gaurang, Nilesh K. Patel, Ashok B. Patel, Amit J. Vyas, and Ajay Patel. "A Review on Bioanalytical Method Development and Validation by LC-MS/MS." Journal of Pharmaceutical and Medicinal Chemistry 2, no. 1 (2016): 95–101. http://dx.doi.org/10.21088/jpmc.2395.6615.2116.9.

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Duggan, Jeffrey X., Faye Vazvaei, and Rand Jenkins. "Bioanalytical method validation considerations for LC–MS/MS assays of therapeutic proteins." Bioanalysis 7, no. 11 (June 2015): 1389–95. http://dx.doi.org/10.4155/bio.15.69.

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Meyer, Lyndsey F., and Dhaval K. Shah. "Development and validation of an LC-MS/MS method for tyrphostin A9." Journal of Pharmaceutical Analysis 9, no. 3 (June 2019): 163–69. http://dx.doi.org/10.1016/j.jpha.2019.03.003.

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Dissertations / Theses on the topic "LC-MS/MS method validation"

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Gorityala, Shashank. "TARGETED AND UNTARGETED OMICS FOR DISEASE BIOMARKERS USING LC-MS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1547093694357568.

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Clarin, Leona. "Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma." Thesis, KTH, Tillämpad fysikalisk kemi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-287570.

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Infections in critically ill patients are a problem for the healthcare system and at any one time, 70 % of all intensive care unit (ICU) patients are treated with antibiotics. Antibiotics bind toproteins in the blood, but only unbound drug can diffuse over capillary membranes and bindto the targeted receptor. Standard protein binding percentages for antibiotics have been developed from studies on healthy volunteers and dosing regimens for patients are adapted accordingly. The determination of the total concentration of antibiotics in patients’ bloodsamples is, based on the standard percentages, ordinarily representative for the pharmacological effect of the antibiotic. However, certain conditions that are common incritically ill patients can alter protein binding percentages, resulting in a larger or smaller unbound fraction. This in turn can result in toxicity or therapeutic failure. The aim of this project was to develop an analytical method for the determination of the unbound concentration of the Beta-Lactam antibiotics cefotaxime, flucloxacillin, cloxacillin and piperacillin in plasma. A method was successfully developed using ultrafiltration for the extraction of unbound analytes and ultra high performance liquid chromatography tandem mass spectrometry, UHPLC-MS/MS, for their quantification. The method was partly validated according to the European Medicines Agency’s guidelines on bioanalytical method validation.
Kritiskt sjuka patienter med infektioner är en börda för sjukvården och 70 % av alla patienter på intensivvårdsavdelningar är ordinerade antibiotika. Antibiotika binder till proteiner i blodet, men enbart den icke-proteinbundna (fria) fraktionen kan diffundera över kapillära membran och binda till receptorer. Standardproteinbindningsgrad för olika antibiotika har utvecklats från studier på friska frivilliga och doseringen av läkemedlen är anpassade därefter. Den totala koncentrationen av antibiotika i patienters blod är vanligen representativ för den farmakologiska effekten. Dock kan vissa sjukdomar påverka proteinbindningsgraden vilket resulterar i en större eller mindre mängd fria antibiotika i blodcirkulationen. Det här kan i sintur resultera i toxicitet eller otillräcklig effekt av läkemedlet. Syftet med det här projektet var att utveckla en analytisk metod för att bestämma den fria koncentrationen av Beta-Lactam antibiotikan cefotaxim, flukloxacillin, kloxacillin och piperacillin i plasma. En metod utvecklades med ultrafiltrering för extraktion av den fria fraktionen och högupplösande vätskekromatografi och tandem masspektrometri, UHPLCMS/MS, för kvantifiering av analyterna. Metoden validerades delvis enligt den Europeiska Läkemedelsmyndighetens riktlinjer för bioanalytisk metodvalidering.
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Harder, Ulrike [Verfasser], and Berthold [Akademischer Betreuer] Koletzko. "Amino acid analysis in biofluids using LC-MS/MS : method development, validation and application in clinical research and dairy science / Ulrike Harder. Betreuer: Berthold Koletzko." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1048361772/34.

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Huang, Qianyang. "Development and Validation of UPLC/MS/MS Methods for Quantification of Gangliosides in the Clinical Study of Ganglioside GM3 Synthase Deficiency." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1472042152.

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Reinsch, Martin. "Entwicklung von Analyseverfahren zur Bestimmung von Ochratoxin A in Lebensmitteln." Doctoral thesis, [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980847982.

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Hellmuth, Christian [Verfasser], and Berthold [Akademischer Betreuer] Koletzko. "LC-MS/MS applications in Targeted Clinical Metabolomics : method development and validation with focus on sulphur-containing amino acids and nonesterified fatty acids / Christian Hellmuth. Betreuer: Berthold Koletzko." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1049891201/34.

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Bunch, Nathan. "Oral Fluid Method Validation for Bowling Green State University." Bowling Green State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1586969951770212.

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Jakob-Rodamer, Verena [Verfasser], Fritz [Gutachter] Sörgel, Ulrike [Gutachter] Holzgrabe, and Petra [Gutachter] Högger. "Development and validation of LC-MS/MS methods to determine PK/PD parameters of anti-infectives / Verena Jakob-Rodamer. Gutachter: Fritz Sörgel ; Ulrike Holzgrabe ; Petra Högger." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1112040285/34.

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Silva, Márcia Aparecida da. "Determinação de clorpropamida em plasma empregando empregando cromatografia liquida de alta eficiencia acoplada a espectrometria de massa sequencial (LC/MS/MS) e sua aplicação em um estudo de bioequivalencia." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309495.

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Orientador: Gilberto de Nucci
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-11T03:36:14Z (GMT). No. of bitstreams: 1 Silva_MarciaAparecidada_D.pdf: 10125609 bytes, checksum: 145f4a9b65da8eb2521c6f76e1d715a9 (MD5) Previous issue date: 2007
Resumo: A biodisponibilidade relativa, de duas formulações de comprimido de clorpropamida 250 mg, foi avaliada em voluntários sadios de ambos os sexos. O estudo foi aberto, aleatorizado, cruzado em dois períodos com intervalo de três semanas, para o qual foram selecionados 36 voluntários. As amostras de sangue foram coletadas antes da administração de dose única de cada formulação, uma Teste (T) e outra Referência (R) e durante 72 horas após a administração. A concentração plasmática de clorpropamida foi determinada por cromatografia líquida de alta eficiência acoplada à espectrometria de massa seqüencial (LC/MS/MS), usando ionização tipo eletrospray no modo positivo com monitoramento de reação múltipla (MRM). O limite de quantificação foi de 0,1 µg/mL. O padrão interno foi a glibenclamida. A ASC0-72, que representa ASC truncada, Cmax e Tmax foram obtidas da curva de concentração plasmática em função do tempo. A ASC foi calculada empregando o método trapezoidal. Apenas ASC0-72 e Cmax de ambas as formulações foram estatisticamente comparados. A média geométrica e o intervalo de confiança (90%) da razão T/R foram respectivamente 93,99 (87,11%¿101,41%) para Cmax e 92,45 (85,96%-99,44%) para ASC0-72. Como o intervalo de confiança (90%), para ASC0-72 e Cmax, apresenta-se dentro do intervalo de confiança de 80-125% proposto pela Agência Nacional de Vigilância Sanitária (Anvisa) e pelo Food and Drug Administration (FDA-EUA), concluiu-se que ambas as formulações estudadas são bioequivalentes, no que diz respeito à magnitude e a velocidade de absorção e, portanto podem ser clinicamente intercambiáveis sem prejuízo terapêutico. Palavras-chave: Clorpropamida, bioequivalência, HPLC acoplada à espectrometria de massa seqüencial (LC/MS/MS), biodisponibilidade, farmacocinética
Abstract: The relative bioavailability between two formulations of chlorpropamide was assessed on the dosage form tablet 250 mg, in healthy volunteers of both sexes. The study was conducted using an open, randomized, two-period crossover design with the 3-week washout interval. Thirty-six subjects were selected. The blood samples were collected at the time prior to dosing and over an interval of 72 hours, of the single dose of each formulation, a Test (T) and another Reference (R). Chlorpropamide plasma concentrations were analyzed by high performance liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS) with positive ion electrospray ionization using multiple reaction monitoring (MRM). The limit of quantification was 0,1 µg/mL for plasma Chlorpropamide analysis. The internal standard was the glibenclamide. The AUC 0-72, which represents AUC truncated, Cmax and Tmax were obtained from plasma concentration-time curve. The AUC was calculated using the trapezoidal rule. Only AUC0-72 and Cmax of the each other formulations were statistically compared. The geometric mean and respective 90% confidence interval (CI) of T/R ratios were 93.99 (87.11%¿101.41%) for Cmax and 92.45 (85.96%-99.44 %) for AUC0-72. Since the interval confidential (90%) for AUC0-72 and Cmax ratios were within the 80-125% interval proposed by the Agência Nacional de Vigilância Sanitária-Brazil (Brasil-Anvisa) and by the Food and Drug Administration (USA-FDA), it was concluded that both the formulations studied are bioequivalent for both the rate and extent of absorption and, therefore can be used interchangeably without impairing therapeutic effectiveness. Key words: Chlorpropamide, bioequivalence, high performance liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS), bioavailability, pharmacokinetic
Doutorado
Doutor em Farmacologia
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Samano, Kimberly L. "Behavioral Assessment and HPLC/MS/MS Identification of the Synthetic Cannabinoid, CP47,497, in Mice." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3328.

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CP47,497 and other synthetic cannabinoid compounds were incipiently synthesized as research tools to investigate the mechanisms by which marijuana affects the brain and to aid in the development of therapeutic agents. Recently, these cannabinoid compounds have resurfaced in the designer drug market, marketed as “herbal incense products” (HIPs). Their popular use has resulted in an alarming rate of reported adverse effects and toxicities. Current legislation classified CP47,497 and several other synthetic cannabinoids compounds as Schedule I agents, but abuse of these compounds persists with serious consequences to public health and safety. In vivo studies examining the behavioral consequences of abused synthetic cannabinoids are limited. As a result, the goals of this research were to elucidate the acute and chronic pharmacological effects of CP47,497 and to develop a bioanalytical method for CP47,497 drug detection in mice. Cannabimimetic effects were evaluated in well-established in vivo models, the tetrad paradigm and drug discrimination assay. The tetrad test is comprised of four outcome measures sensitive to the primary psychoactive cannabinoid present in marijuana, delta-9-tetrahydrocannabinol (THC): catalepsy (bar test), antinociception (tail withdrawal latency), hypothermia, and decreases in spontaneous locomotor activity. While many pharmacological agents can produce one or a subset of these tetrad effects, drugs that activate CB1 receptors produce characteristic effects in all four parameters. An HPLC/MS/MS method was developed and confirmed the presence of CP47,497 in brain. We investigated whether CB1 receptors mediate the pharmacological effects of CP47,497. Cumulative dose-response experiments determined CP47,497 is more potent than THC in vivo in using multiple behavioral assays. Complementary pharmacological (CB1 receptor antagonist, rimonabant) and genetic (CB1 (-/-) mice) approaches were used to investigate whether CB1 receptors mediate the effects of CP47,497. Rimonabant (3 mg/kg or 10 mg/kg, depending on independent measure) blocked all cannabinoid-like pharmacological effects of CP47,497. Supporting these findings, CB1(-/-) mice were resistant to cannabimimetic effects of CP47,497. CP47,497 fully substituted for THC in the drug discrimination assay, with a potency of more than 5 times that of THC. Collectively, these results indicate that CP47,497 is markedly more potent (i.e. 5-8 fold) than THC, and its repeated administration produces tolerance to the cataleptic, antinociceptive, hypothermic and hypolocomotor effects in mice, with significant presentation of somatic withdrawal signs (paw flutter and head shakes) upon drug cessation. These findings are consistent with the high incidence of adverse events in humans abusing synthetic cannabinoids.
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Books on the topic "LC-MS/MS method validation"

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LC-MS/MS Method for Mycotoxin Analysis. MDPI, 2017. http://dx.doi.org/10.3390/books978-3-03842-607-3.

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A novel method for the determination of sildenafil (Viagra) and its metabolite (UK-103,320) in postmortem specimens using LC/MS/MS and LC/MS/MS/MS: Final report. Washington, D.C: U.S. Dept. of Transportation, Federal Aviation Administration, Office of Aviation Medicine, 2000.

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Book chapters on the topic "LC-MS/MS method validation"

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Garofolo, Fabio. "LC-MS Instrument Calibration." In Analytical Method Validation and Instrument Performance Verification, 197–220. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2004. http://dx.doi.org/10.1002/0471463728.ch13.

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Zhang, Jie, Tapan K. Majumdar, Jimmy Flarakos, and Francis L. S. Tse. "Best Practices in LC-MS Method Development and Validation for Dried Blood Spots." In Handbook of LC-MS Bioanalysis, 379–89. Hoboken, NJ, USA: John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch30.

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Arnold, Mark E., Rafael E. Barrientos-Astigarraga, Fabio Garofolo, Shinobu Kudoh, Shrinivas S. Savale, Daniel Tang, Philip Timmerman, and Peter van Amsterdam. "Current Regulations for Bioanalytical Method Validations." In Handbook of LC-MS Bioanalysis, 37–46. Hoboken, NJ, USA: John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch4.

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Meng, Min, and Patrick K. Bennett. "Method Development, Validation, and Sample Analysis for Regulated Quantitative Bioanalysis Using LC-MS/MS." In LC-MS in Drug Bioanalysis, 33–66. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-3828-1_2.

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Begou, Olga, Helen G. Gika, Georgios A. Theodoridis, and Ian D. Wilson. "Quality Control and Validation Issues in LC-MS Metabolomics." In Methods in Molecular Biology, 15–26. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7643-0_2.

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Li, Wenkui. "Considerations in Development and Validation of LC-MS/MS Method for Quantitative Analysis of Small Molecules in Dried Blood Spot Samples." In Dried Blood Spots, 168–78. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118890837.ch14.

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Yu, Jingbo, Nengsheng Ye, Xuexin Gu, and Ni Liu. "VALIDATION OF AN HPLC-DAD-ESI/MS/MS METHOD FOR THE CLASSIFICATION OF GREEN TEAS." In Computer and Computing Technologies in Agriculture II, Volume 3, 1707–19. Boston, MA: Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-0213-9_21.

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Nemirovskiy, Olga, Wenlin Wendy Li, and Gabriella Szekely-Klepser. "Design and Validation of an Immunoaffinity LC–MS/MS Assay for the Quantification of a Collagen Type II Neoepitope Peptide in Human Urine: Application as a Biomarker of Osteoarthritis." In Methods in Molecular Biology, 253–70. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-711-2_15.

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Lin, Zhongping John, Wenkui Li, and Naidong Weng. "Lc-Ms Bioanalytical Method Transfer." In Handbook of LC-MS Bioanalysis, 65–70. Hoboken, NJ, USA: John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch6.

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Middleberg, Robert A., and Joseph Homan. "LC-MS/MS Method for the Detection of Common Laxatives." In Methods in Molecular Biology, 157–66. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-934-1_14.

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Conference papers on the topic "LC-MS/MS method validation"

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Kubczak, Christian, Tiziana Margaria, Arno Fritsch, and Bernhard Steffen. "Biological LC/MS Preprocessing and Analysis with jABC, jETI and xcms." In Second International Symposium on Leveraging Applications of Formal Methods, Verification and Validation (isola 2006). IEEE, 2006. http://dx.doi.org/10.1109/isola.2006.48.

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Magni, Paola. "Entomotoxicology: Development and validation of CG-MS and LC/MS-MS methods for nicotine, metanfetamine, endosulfan, and coumatetraryl detection in blowflies." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94572.

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Zangarini, Monique, Neil Rajan, Marina Danilenko, Philip Berry, and Gareth J. Veal. "Abstract 333: Development and validation of a LC-MS/MS method for the quantification of the tropomyosin receptor kinase (Trk) inhibitor pegcantratinib in human skin tumors." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-333.

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Miralles Cardiel, Esther, Marcelle Silva-Abreu, Ana Cristina Calpena, and Isidre Casals. "Nanoparticles as carrier for improve therapeutic efficacy of pioglitazone in ocular inflammatory disorders: development and validation of a high throughput LC–MS/MS method for quantitation in ocular tissues." In The 1st International Electronic Conference on Pharmaceutics. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecp2020-08685.

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Muller, I. B., P. Heydari, M. Lin, E. A. Struys, R. Hebing, C. J. van der Laken, D. van Schaardenburg, et al. "AB0236 Development and validation of a sensitive lc-ms/ms-based method for analysis of enzymatic activity of folylpolyglutamate synthetase and methotrexate polyglutamates in peripheral blood mononuclear cells of rheumatoid arthritis patients." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.5602.

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Zhan, Shuyu, Amy Paik, Felicia Onyeabor, Baoyue Ding, Sunil Prabhu, and Jeffrey Wang. "Abstract 6252: Development and validation of an LC/MS/MS method for the determination of celastrol in rat plasma and its application to the pharmacokinetic evaluation of celastrol-encapsulated silk fibroin nanoparticles." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-6252.

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Stair, Todd, and Gary Makowiecki. "Improved Validation Method for Annular Casing Packers." In SPE/IADC Middle East Drilling Technology Conference and Exhibition. Society of Petroleum Engineers, 2016. http://dx.doi.org/10.2118/178212-ms.

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Krueger, Aaron M., Vincent A. Mousseau, and Yassin A. Hassan. "Rigorous Code Verification: An Additional Tool to Use With the Method of Manufactured Solutions." In ASME 2019 Verification and Validation Symposium. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/vvs2019-5166.

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Abstract The Method of Manufactured Solutions (MMS) has proven to be useful for completing code verification studies. MMS allows the code developer to verify that the observed order-of-accuracy matches the theoretical order-of accuracy. Even though the solution to the partial differential equation is not intuitive, it provides an exact solution to a problem that most likely could not be solved analytically. The code developer can then use the exact solution as a debugging tool. While the order-of-accuracy test has been historically treated as the most rigorous of all code verification methods, it fails to indicate code “bugs” that are of the same order as the theoretical order-of-accuracy. The only way to test for these types of code bugs is to verify that the theoretical local truncation error for a particular grid matches the difference between the manufactured solution (MS) and the solution on that grid. The theoretical local truncation error can be computed by using the modified equation analysis (MEA) with the MS and its analytic derivatives, which we call modified equation analysis method of manufactured solutions (MEAMMS). In addition to describing the MEAMMS process, this study shows the results of completing a code verification study on a conservation of mass code. The code was able to compute the leading truncation error term as well as additional higher-order terms. When the code verification process was complete, not only did the observed order-of-accuracy match the theoretical order-of-accuracy for all numerical schemes implemented in the code, but it was also able to cancel the discretization error to within roundoff error for a 64-bit system.
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Ingsoy, P., and S. M. Skjaeveland. "Experimental Validation of a New Method for Optimizing Miscible Flooding of Stratified Reservoirs." In SPE/DOE Enhanced Oil Recovery Symposium. Society of Petroleum Engineers, 1990. http://dx.doi.org/10.2118/20241-ms.

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Dupuis, Dominique, Didier Augis, Andre Sagot, Thierry Delahaye, Ulysse Cartalos, and Bruno Burban. "Validation of Kick Control Method and Pressure Loss Predictions on a Slim Hole Well." In SPE/IADC Drilling Conference. Society of Petroleum Engineers, 1995. http://dx.doi.org/10.2118/29348-ms.

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Reports on the topic "LC-MS/MS method validation"

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Owens, J., and C. Koester. Analysis of Thiodiglycol: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS777. Office of Scientific and Technical Information (OSTI), July 2008. http://dx.doi.org/10.2172/945866.

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Owens, J., A. Vu, and C. Koester. Analysis of Ethanolamines: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS888. Office of Scientific and Technical Information (OSTI), October 2008. http://dx.doi.org/10.2172/945589.

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Owens, J., A. Vu, and C. Koester. Analysis of Phosphonic Acids: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS999. Office of Scientific and Technical Information (OSTI), October 2008. http://dx.doi.org/10.2172/945524.

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Owens, J., and C. Koester. Analysis of Carbamate Pesticides: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS666. Office of Scientific and Technical Information (OSTI), May 2008. http://dx.doi.org/10.2172/945575.

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