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1

Coscollà, Raga Clara. "Multi-residue methods for the analysis of pesticides in airborne particulate matter by LC_MS/ and GC-MS/MS. Monitoring levels in the atmosphere." Doctoral thesis, Universitat de València, 2011. http://hdl.handle.net/10803/81296.

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Los plaguicidas actualmente utilizados en agricultura (CUPs) pueden encontrarse en la atmósfera como consecuencia de su uso intensivo en zonas agrícolas sobre todo durante el periodo de aplicación. Más de 300 sustancias activas están actualmente aprobadas por la UE y pueden ser aplicadas en distintos cultivos según la Directiva 91/414/CEE. La cantidad total de plaguicidas utilizados en la (EU-27) durante el 2008 fue de unas 310.011 toneladas de sustancia activa, con Francia (25.3%), España (12.9%) e Italia (13.3%) como los tres países con mayor consumo. La emisión de los plaguicidas durante
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2

Pereira, Denize Duarte. "Determinação de Flunitrazepam e 7¬aminoflunitrazepam em soro por cromatografia líquida de alta eficiência acoplada à espectrometria de massa em tandem com a utilização de extração on line: aspecto forense." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-29012018-154046/.

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Atualmente os benzodiazepínicos constituem o grupo de fármacos de prescrição mais consumidas em todo o mundo. Além da utilização desta classe farmacológica como fármacos de abuso, mais recentemente seu uso está associado a uma nova cultura psicodélica emergente. O termo \"club drugs\" tem sido usado para descrever estes fármacos que levam a efeitos psicodélicos e euforizantes. Acresça-se a isto à preocupante utilização destas substâncias em situações de estupro e/ou assalto, as chamadas \"drug-facilitated sexual assault\", destacando-se o flunitrazepam. Devido às pequenas doses administradas e
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3

Lorenz, Anja. "Kooperationsunterstützung in einem Learning Content Management System (LCMS)." Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-82022.

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Learning Content Management Systeme (LCMS) unterstützen die professionelle Erstellung, Verwaltung und Auslieferung von Lernmaterialien [BHMH02]. Die Speicherung der hierfür verarbeiteten Lerninhalte in einem zentralen Repository ermöglicht neben deren Wiederverwendung auch den Zugriff für mehrere Nutzer und somit das Zusammenführen der verschiedenen Kompetenzen, die während der Erstellung benötigt werden: Die mithilfe der Lernmaterialien zu vermittelnden Inhalte müssen nicht nur fachlich richtig, sondern auch didaktisch, gestalterisch und technisch für ein oder mehrere Zielgruppen individuell
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Lorenz, Anja. "Unterstützung der Nutzung des kollektiven Wissens in einem LCMS." Universitätsbibliothek Chemnitz, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-70694.

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Bei der Erstellung von Lernmaterialien für die Aus- und Weiterbildung in Unternehmen treffen verschiedene Anforderungen aufeinander: Die Kursmaterialien sollen fachlich richtig, didaktisch sinnvoll und gestalterisch ansehnlich aufbereitet sein. Zugleich finden sich in den Unternehmen unterschiedliche Zielgruppen und Einsatzzwecke, sodass hohe Ansprüche an den effektiven Einsatz und somit an die Wiederverwendbarkeit einmal erstellter Lerninhalte bestehen. Learning Content Management Systeme (LCMS) begegnen diesen Herausforderungen und stellen Funktionalitäten zur Erstellung, Bearbeitung, Verwal
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Lorenz, Anja. "Über kurz oder lang. Ein Schlichtungsversuch zur Debatte über Micro- und Macrolearning." Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-82098.

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Die Vorteile von Microlearning gegenüber langatmiger (Online-) Schulungen liegen auf der Hand: Sie führen schnell zu Lernerfolgen, unterbrechen den Alltag nur kurz und entsprechen der Kultur der „Net Generation“. Mit einem Blogeintrag stellte sich Gabi Reinmann [Rei10a] diesen Argumenten offen entgegen und sprach sich für die Notwendigkeit langer Lernphasen für eine umfassende Bildung aus. Dabei widersprechen sich die Lernkonzepte nicht, sondern können und müssen einander ergänzen. Auch die dafür benötigten Lernmaterialen sollten nicht isoliert voneinander erstellt werden: durch eine geeignete
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6

Michaud, François-Thomas. "Profilage protéomique par analyse multivariée de signaux LCMS appliqué en ingénierie cellulaire." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/26366/26366.pdf.

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7

Melton, Tyler, and Stacy D. Brown. "Monitoring the Effects of Chlorination Treatment on Sulfamethazine using LCMS-IT-TOF." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/5291.

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8

Blanchette, Maxime. "Development of a method for the LCMS determination of vicinal diketones in beer." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100772.

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No existent analytical method allowed the determination of the vicinal diketones (VDK), 2,3-butanedione (diacetyl) and 2,3-pentanedione, by liquid chromatography/mass spectrometry (LC/MS). An LC/MS method was developed for the simultaneous determination of diacetyl and 2,3-pentanedione in beer. A method allowing the determination of the amino acids (AA) related to the formation of VDK during fermentation was also developed. VDK were derivatized with o-phenylenediamine (OPDA) to form quinoxaline compounds. The reaction of VDK with OPDA was studied to optimize reaction time. Conversion of the di
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9

Felts, Jennifer Elaine. "An evaluation of extraction parameters and LCMS analysis of oligonucleotides from biological matrices." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-3/r1/feltsj/jenniferfelts.pdf.

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10

Brown, Stacy D., J. T. Connor, N. C. Smallwood, and Ralph A. Lugo. "Quantitative Determination of Lansoprazole for Stability Study in Oral Suspensions Using LCMS-IT-TOF." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/5293.

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11

Roberts, Joanne B. "Determination and identification of drug and chemical metabolites in waste water by LCMS/MS." Thesis, Glasgow Caledonian University, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.726806.

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12

Lorenz, Anja. "Über kurz oder lang. Ein Schlichtungsversuch zur Debatte über Micro- und Macrolearning." Hochschule Zittau/Görlitz, 2010. https://monarch.qucosa.de/id/qucosa%3A19644.

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Die Vorteile von Microlearning gegenüber langatmiger (Online-) Schulungen liegen auf der Hand: Sie führen schnell zu Lernerfolgen, unterbrechen den Alltag nur kurz und entsprechen der Kultur der „Net Generation“. Mit einem Blogeintrag stellte sich Gabi Reinmann [Rei10a] diesen Argumenten offen entgegen und sprach sich für die Notwendigkeit langer Lernphasen für eine umfassende Bildung aus. Dabei widersprechen sich die Lernkonzepte nicht, sondern können und müssen einander ergänzen. Auch die dafür benötigten Lernmaterialen sollten nicht isoliert voneinander erstellt werden: durch eine geeignete
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13

Press, Mark Gottfried Clarence. "But are they Lutheran? an analytical study of the work and thought of LCMS church planters /." Theological Research Exchange Network (TREN) Access this title online, 2004. http://www.tren.com.

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14

Lorenz, Anja, and Lars Fassmann. "Lernmaterialien effektiv aufbereiten und wiederverwenden." Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-82101.

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Hochwertige Schulungsmaterialien für die unternehmensinterne Weiterbildung sind ein erster wichtiger Schritt hin zu einem effektiven Wissensmanagement. Einmal erstellt, können digitale Lerninhalte immer wieder eingesetzt werden. Allerdings ist die Pflege und Anpassung an die Anforderungen verschiedener Zielgruppen und Auslieferungsformate mit herkömmlicher E-Learning-Autorensoftware sehr aufwändig. Nicht so bei serverbasierter Software – sie ermöglicht die Planung, Erstellung, Auslieferung, Verwaltung und Pflege wiederverwendbarer digitaler Lernmaterialien. Dies ist der Ausgangspunkt für eine
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Russell, Susan P. "Characterizing Modified Nucleosides in RNA by LC/UV/MS." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353951985.

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Malkin, Douglas Scott, and Douglas Scott Malkin. "An Investigation of a Novel Monolithic Chromatography Column, Silica Colloidal Crystal Packed Columns." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/193936.

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Many researchers have investigated ways to improve the separation power of conventional chromatography, most notable is the development of ultra-high performance liquid chromatography (UHPLC). However, only slight improvements in separation efficiency have been achieved up to this point, and unfortunately, modern reversed phase liquid chromatography (RPLC) methods do not have high enough resolving power to analyze complex proteomic mixtures.Uniformly sized silica particles from 10 nm to 1 micron are known to self-assemble into a highly ordered face centered cubic crystal. Silica colloidal crys
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Lorenz, Anja, and Lars Fassmann. "Lernmaterialien effektiv aufbereiten und wiederverwenden." Büro für Medien Oliver Lehnert e.K, 2010. https://monarch.qucosa.de/id/qucosa%3A19645.

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Hochwertige Schulungsmaterialien für die unternehmensinterne Weiterbildung sind ein erster wichtiger Schritt hin zu einem effektiven Wissensmanagement. Einmal erstellt, können digitale Lerninhalte immer wieder eingesetzt werden. Allerdings ist die Pflege und Anpassung an die Anforderungen verschiedener Zielgruppen und Auslieferungsformate mit herkömmlicher E-Learning-Autorensoftware sehr aufwändig. Nicht so bei serverbasierter Software – sie ermöglicht die Planung, Erstellung, Auslieferung, Verwaltung und Pflege wiederverwendbarer digitaler Lernmaterialien. Dies ist der Ausgangspunkt für eine
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18

Li, Siwei. "High Throughput Automated Comparative Analysis of RNAs Using Isotope Labeling and LC-MS/MS." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384427990.

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19

Lomberský, Jakub. "Využití LMS v podnikové praxi." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-149989.

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The goal of my master's thesis is a description of the Moodle learning management system, and demonstration of its usability in human resources supporting the whole process of systematical approach in training and further development of employees. In order to confirm its applicability I describe the real system implementation. My master's thesis also includes supporting objectives to support the main objectives. The purpose of their use is to introduce the reader to the problematic of training and further development. Supporting objectives are: to introduce the issue of training and further de
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20

Alsudairy, Ziad. "Identification of Major Organic Constituents of Saffron Isolated by Solid Phase Extraction and Column Chromatography." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2019. http://digitalcommons.auctr.edu/cauetds/200.

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Water extracts of saffron, a spice derived from the plant Crocus Sativus L. obtained from India and Iran, were analyzed by liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). The components in the extracts were separated on four different solid phase extraction cartridges with four different solvents and by silica gel column. Analysis was done by GC-MS, LC-MS and UV-Vis spectroscopy. The extracts separated into three distinct bands (two bright yellow and one orange) on the silica gel column. Based on GC-MS, the extracted compounds show many structu
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21

Martins, Gabriel Nobrega da Rocha. "Detecção e quantificação de derivados e intermediários de hispidina em fungos bioluminescentes e plantas por LC-MS/MS." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46137/tde-24092018-160058/.

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A bioluminescência desperta o interesse humano há muitos séculos. Presente em quatro dos sete reinos taxonômicos, Monera, Chromista, Animalia e Fungi, cada um com mecanismos muito diferentes. Pode-se dizer que o estudo químico da bioluminescência começou com os experimentos de Dubois no século XIX, que cunhou os termos luciferina e luciferase, termos genéricos para o substrato e enzima envolvidos na reação, respectivamente. No caso específico de fungos, o envolvimento de enzimas foi debatido por quase cinco décadas, após a proposta enzimática de Airth e Foerster na década de 1960 e a não enzim
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Dürr, Julia. "Folate, choline, betaine, resistant starch & dietary fiber in Swedish lentils : Effect of cultivar and growing conditions." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-96847.

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Background: One key component in the development of sustainable farming and foodstuffs is to increase the cultivation of legumes, due to their environmental and health benefits. Legumes contain several essential vitamins and minerals, protein and fiber, but cultivation can be problematic due to their weak stem strength which results in loss of crops as a result of crop lodging and susceptibility to weed invasion. One possible solution is co-cultivation with cereal crops such as oats as they provide support and outcompete weed growth, however, it is still unknown if co-cultivation will affect t
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Correia, Carolina Mourão. "Fitorremediação de águas contaminadas com fármacos." Master's thesis, Universidade de Évora, 2010. http://hdl.handle.net/10174/16262.

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A presença de compostos farmacêuticos e seus metabolitos no ambiente aquático tornou-se nos últimos anos num problema ambiental emergente. Em particular, uma especial atenção tem vindo a ser dada aos antibióticos dada a sua ecotoxicidade e devido ao problema específico de desenvolvimento de estirpes bacterianas resistentes à sua acção. A baixa eficiência das ETARs na remoção da maior parte deste tipo de poluentes é uma das principais razões para a contaminação dos recursos hídricos e, portanto, é necessário o desenvolvimento de novos processos de tratamento que sejam eficientes na remoção de f
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Rådemar, Joakim. "Concerning the transition of learning : A case study of the LMS and e-learning situation at university department level." Thesis, Uppsala universitet, Institutionen för informatik och media, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-295831.

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Uppsala University (UU) is a complex institution, which combines geographically disparate campuses, as well as distance education programs and metropolitan sites for international students. Like many other universities, UU is currently reviewing its e­learning and Learning Management Systems (LMS) situation. In effect, signalling the desire for a strategic change in the future management of learning and teaching arrangement. This thesis analyzes UU’s strategic position and current drivers of change from a LMS and e­learning perspective. Conclusions drawn on the results suggests both retarding
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Jones, Natalie Kaye. "Tetracyclines In Swine Waste." TopSCHOLAR®, 2014. http://digitalcommons.wku.edu/theses/1326.

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Antibiotics are added to animal feeds as prophylactic agents and to encourage weight gain in livestock. However, there is concern that the widespread use of antibiotics in animal agriculture encourages for the selection of resistance genes and has contributed to the rise of multiply antibiotic resistant strains of pathogenic bacteria. For this reason, there is interest in quantifying antibiotics in environmental samples. The determination of three antibiotics in swine waste, namely chlortetracycline, tetracycline and oxytetracycline, using LC-MS with electrospray ionization is presented here i
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Robin, Tiphaine. "Mise au point de méthodes de recherche large de xénobiotiques par chromatographie liquide couplée à la spectrométrie de masse en tandem." Thesis, Limoges, 2020. http://www.theses.fr/2020LIMO0052.

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Dans de nombreux contextes de toxicologie clinique, le screening ou criblage toxicologique est la première analyse effectuée chez un patient, lorsque la nature ou la présence même de médicaments ou de toxiques est totalement inconnue. Le plus souvent, le screening précède la mise en œuvre de méthodes quantitatives spécifiques. Les méthodes d’extractions peuvent être diverses mais celles-ci restent en général manuelles.Les objectifs de nos travaux étaient de développer des méthodes de screening qualitatives, quantitatives et automatisées avec un spectromètre de masse en tandem (modèle 8060 ; Sh
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Rocha, Otávio Pelegrino. "Disposição cinética dos enantiômeros da ifosfamida em pacientes portadoras de câncer de colo do útero." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-26062013-092507/.

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A ifosfamida é um pró-fármaco que apresenta um átomo de fósforo quiral, disponível na clínica como mistura racêmica dos enantiômeros(+)-(R)-ifosfamida e (-)-(S)-ifosfamida para a utilização na quimioterapia. O objetivo do presente estudo foi o de avaliar a disposição cinética dos enantiômeros da ifosfamida em plasma de pacientes portadoras de câncer de colo do útero. As pacientes investigadas (n=6) receberam 2,5 g/m2 de ifosfamida racêmica administrada como infusão de 12 horas, sendo coletadas amostras de sangue imediatamente antes da administração e em 6, 10, 11, 12, 13, 14, 16, 18, 20 e 22 h
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Fly, Richard Derek. "Approaches for the study of leaf carbohydrate metabolic compartmentation in arabidopsis thaliana." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5332.

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Thesis (MSc (Plant Biotechnology))--University of Stellenbosch, 2010.<br>Includes bibliography.<br>ENGLISH ABSTRACT: The study of plants on a sub-cellular level is an important, yet challenging area and its application allows for novel insight into the understanding of metabolism and its regulation. In this study I describe the development of a reverse phase liquid chromatography mass spectrometry (RPLC-MS) technique in which 29 phosphorylated and nucleotide sugars could be detected and quantified. The method was validated with the use of authentic standards and the system displayed very good
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Friggi, Caroline do Amaral. "Determinação multiclasse de resíduos de agrotóxicos e medicamentos veterinários em carnes por LC-MS/MS." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/4219.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The agribusiness has been incorporating new technologies in the production of meat, including good management of farms, health, balanced diet, breeding and integrated production. Allied to this, there is a growing concern with issues related to residues and contaminants in animals intended for food production. In the study, were compared four extraction methods based on the method QuEChERS for the determination of 79 pesticides and 15 veterinary drugs analyzed by Liquid Chromatography coupled to tandem Mass Spectrometry in samples
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Leite, Flávia Pine. "Determinação de club dugs em sangue total por cromatografia líquida acoplada a espectrometria de massas com analisador hí­brido quadrupolo-tempo de voo (LC-QTOF-MS)." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-11062018-110009/.

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As chamadas club drugs compreendem um vasto grupo de substâncias frequentemente utilizadas em bares, festas e raves, com a finalidade de intensificar o contato social e a estimulação sensorial. Englobam desde substâncias sintéticas comumente conhecidas, como a anfetamina, a metanfetamina, o MDMA, até moléculas de surgimento mais recente, denominadas novas substâncias psicoativas. Isoladas ou associadas a outras drogas, é possível que sejam causa de morte per se, ou que predisponham o usuário a envolver-se em situações potencialmente fatais, sendo necessário que os órgãos de Perícia Criminal (I
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Rainville, Paul. "The investigation and application of alternative strategies for LC/MS based bioanalytical research." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-investigation-and-application-of-alternative-strategies-for-lcms-based-bioanalytical-research(9e73e438-c941-4e4f-8502-69f6e4decef9).html.

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The work presented here demonstrates two unique approaches in the application of LC/MS for the analysis of drugs and endogenous compounds in biofluids. First, the use of basic aqueous mobile phases in conjunction with both methanol and acetonitrile by LC/MS operating in electrospray positive ionization mode was investigated. Second, the design and development of a prototype ceramic micro-fluidic device (CMFD) and optimized MS source was carried out. The CMFD was packed with sub 2 μm bridged ethyl hybrid (BEH) chromatographic particles that could withstand operating pressures of up to 12,000 ps
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Donadio, Mauro. "Progettazione e sviluppo di estensioni per AContent." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/4553/.

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In questo documento di tesi viene descritta la progettazione e la realizzazione di estensioni per il sistema di authoring AContent. L'idea è di creare un'estensione dell'authoring tool che implementi il concetto di template ovvero strumenti di grande efficacia e di facile utilizzo nelle fasi di redazione dei contenuti. Si prevede di aggiungerli ad AContent senza la necessità di integrare un intero motore di template ma utilizzando strutture dati esistenti e specifiche standard di e-learning. I servizi aggiuntivi da offrire agli autori sono stati organizzati secondo tre approcci diversi da cui
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Alves, Marcela Nogueira Rabelo. "Análise de canabinóides e cocaínicos em amostras de cabelo e sua correlação com sintomas psiquiátricos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-10082015-082913/.

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O consumo dos diferentes tipos de drogas está associado a problemas sociais, econômicos e de saúde pública, em todas as regiões no mundo. Dentre os problemas de saúde pública, podemos destacar a alta prevalência de comorbidade entre o uso de drogas e os transtornos mentais. A Cannabis, a cocaína e o crack são as drogas ilícitas mais consumidas no Brasil. A utilização do cabelo como matriz biológica para determinação destas drogas permite avaliar o uso crônicos pelos indivíduos, uma vez que o cabelo é uma matriz estável, de fácil manipulação e a janela de detecção depende apenas do comprimento
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Sobral, Sónia Rolland. "B-Learning em disciplinas introdutórias de programação." Doctoral thesis, https://repositorium.sdum.uminho.pt/bitstream/1822/9054/1/CapitulosFinal030408vf.pdf, 2008. https://repositorium.sdum.uminho.pt/bitstream/1822/9054/1/CapitulosFinal030408vf.pdf.

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Tese de Doutoramento em Tecnologias e Sistemas de Informação na Área de Sociedade de Informação, apresentada na Universidade do Minha- Escola de Engenharia.<br>As Tecnologias de Informação e Comunicação já são parte integrante da vida dos cidadãos e dos lares portugueses. A nova era da sociedade do conhecimento conjuga-se na escola com as mudanças do aluno e do seu perfil e o processo de Bolonha. O ensino a distância mediado pela Web e a sua generalização, em particular a aprendizagem mista, b-learning, pelas suas características intrínsecas como o auto-estudo a qualquer hora e em qua
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Jordão, Nuno Ricardo de Oliveira. "Study of the cell surface proteome for the analysis of Parkinson’s disease associated DJ-1 mutations." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15483.

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Mestrado em Biotecnologia - Biotecnologia Molecular<br>Parkinson’s disease (PD) is a neurodegenerative disease, characterized with selective neurodegeneration and dopamine depletion. Despite most cases appear to have sporadic origin, it has been associated various monogenic mutations to the onset of a parkinsonian phenotype. DJ-1 protein is of particular interest given its neuroprotective role against oxidative stress and mitochondria impairment, and the identification of several mutations correlated with early onset PD. For this study, it were then produced two pathological mutations of DJ-1
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Chambers, Erin. "Improving the sensitivity and specificity of LC/MS to enable bioanalysis of therapeutic and endogenous proteins and peptides." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/improving-the-sensitivity-and-specificity-of-lcms-to-enable-bioanalysis-of-therapeutic-and-endogenous-proteins-and-peptides(06b872cd-02df-4afa-8a8c-793cbd209e32).html.

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This thesis establishes LC/MS as a viable, robust, and attractive alternative analytical platform to ligand binding assays for the quantification of therapeutic and endogenous peptides/proteins in biological fluids. A rigorous investigation of the parameters that affect assay sensitivity, specificity and robustness revealed that a careful combination of mixed-mode solid phase extraction, reversed-phase liquid chromatography utilizing sub 2μm charged surface solid core stationary phases, coupled to tandem quadrupole mass spectrometry can deliver a generic platform for assay development. By exte
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Koot, Dwayne Jonathan. "Strategic pre-clinical development of Riminophenazines as resistance circumventing anticancer agents." Thesis, University of Pretoria, 2012. http://hdl.handle.net/2263/24163.

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Cancer is responsible for upward of 13% of human deaths. Contemporary chemotherapy of disseminated cancer is often thwarted by dose limiting systemic toxicity and by multi-drug resistance (MDR). Riminophenazines are a novel class of potential anticancer agents that possess a potent multi-mechanistic antineoplastic action. Apart from their broad action against intrinsic, non-classical resistance, Riminophenazines inhibit the action of Pgp and hypothetically all ABC transporters demonstrating their great utility against classical MDR. Considering that combination chemotherapy is the norm, the vi
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Brolio, Debora Richter. "A tecnologia na educação: o uso de um sistema gerenciador de conteúdo e aprendizagem." reponame:Repositório Institucional do FGV, 2017. http://hdl.handle.net/10438/18096.

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Submitted by Débora Richter Brólio (debora.richter@gmail.com) on 2017-03-23T19:29:42Z No. of bitstreams: 1 Debora Richter Brolio - Tecnologia e Educacao.pdf: 2650713 bytes, checksum: 5cb436474bd5da005c9f4c049773a304 (MD5)<br>Approved for entry into archive by Pamela Beltran Tonsa (pamela.tonsa@fgv.br) on 2017-03-23T19:32:52Z (GMT) No. of bitstreams: 1 Debora Richter Brolio - Tecnologia e Educacao.pdf: 2650713 bytes, checksum: 5cb436474bd5da005c9f4c049773a304 (MD5)<br>Made available in DSpace on 2017-03-24T13:53:48Z (GMT). No. of bitstreams: 1 Debora Richter Brolio - Tecnologia e Educacao.p
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TSENG, CHIH-WEI, and 曾智偉. "The Design of Embedded Collaborative LCMS Broker." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/46335407959226497165.

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碩士<br>大葉大學<br>資訊工程學系碩士在職專班<br>95<br>This study mainly has two contributions. First, this study proposes a design for Embedded Learning Content Management System Broker (Embedded LCMS Broker) with load-balancing capabilities. Through this Embedded LCMS Broker with load-balancing function, one is able to balance the loading of multiple LCMS by dynamic recording method. The proposed decomposed system platform includes the Learning Management System (LMS) that records online education, LCMS that provides the teaching material, as well as Embedded LCMS Broker that distributes the network loading by
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Lyu, Shih-Ren, and 呂世仁. "A SCORM-Compliant LCRMS Based on Dublin Core and RDF for Reusable Learning Object." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/14537367043409880594.

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碩士<br>國立中正大學<br>資訊工程研究所<br>91<br>In this thesis, the Learning Content Recommend Management System (LCRMS) based on Dublin Core and Resource Description Framework (RDF) is proposed for managing the knowledge and sharing the SCORM-Compliant learning content. The system consists of a content package suite and a content recommend management system. A friendly GUI for creating a reusable, sharable and SCORM-compliant learning material is provided by the suite. The learning material can be imported into any SCORM-compliant learning management system. Additionally, the Library of Congress Classificat
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Michaud, François-Thomas. "Profilage protéomique par analyse multivariée de signaux LCMS appliqué en ingénierie cellulaire /." 2009. http://www.theses.ulaval.ca/2009/26366/26366.pdf.

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Thèse (Ph. D.)--Université Laval, 2009.<br>Texte en français avec résumés en français et en anglais. Bibliogr.: f. 157-170. Publié aussi en version électronique dans la Collection Mémoires et thèses électroniques.
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Keith, Matthew Ward Cheryl A. "A model for studying World War II-era LCMs in the archaeological record." 2004. http://etd.lib.fsu.edu/theses/available/etd-11142004-230531.

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Thesis (M.A.)--Florida State University, 2004.<br>Advisor: Dr. Cheryl A. Ward, Florida State University, College of Arts and Sciences, Dept. of Anthropology. Title and description from dissertation home page (viewed Jan. 14,2005). Includes bibliographical references.
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"Untargeted Lcms Serum Metabolomics Of The Sierra Leonean Lassa Fever Patient And Metaanalysis Of The Virion Proteome." 2016.

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Araújo, Ana Sofia Fernandes. "Validação do método de quantificação de micotoxinas por LCMS/MS em farinhas de trigo, aveia e milho." Dissertação, 2017. https://hdl.handle.net/10216/110738.

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Araújo, Ana Sofia Fernandes. "Validação do método de quantificação de micotoxinas por LCMS/MS em farinhas de trigo, aveia e milho." Master's thesis, 2017. https://hdl.handle.net/10216/110738.

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Fleischer, Alexander [Verfasser]. "Entwurf und Implementierung innovativer Architekturen für Learning Content Management Systeme (LCMS) zum Einsatz im erlösorientierten Bildungsexport / von Alexander Fleischer." 2008. http://d-nb.info/99458220X/34.

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Zhen, Lin. "Effects of filtration sterilization on the stability of ketamine, selected benzodiazepines and metabolites in female urine." Thesis, 2017. https://hdl.handle.net/2144/20791.

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Benzodiazepines (Benzos) and ketamine (K) are compounds that have been encountered in Drug-Facilitated Sexual Assault (DFSA) cases. Due to the intimate nature of these crimes, evidence collection is often postponed due to delays and/or reluctance in reporting these crimes. Further delays in analysis may be encountered in laboratories with large caseloads and/or backlogs. Drug identification in biological samples is important to determine whether victims knowingly or unknowingly took an impairing substance, however, the results could be negative due to chemical degradation over a long storag
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Pinto, Carlos Manuel dos Prazeres. "O e-Learning e as plataformas para gestão de conteúdos e aprendizagens LMS/LCMS: a utilização no contexto do ensino de Informática." Master's thesis, 2016. http://hdl.handle.net/10348/6823.

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Dissertação de Mestrado em Ensino de Informática<br>O presente relatório de estágio relata de forma crítica a experiência da prática de ensino supervisionada no segundo ciclo do ensino básico e ensino profissional, na Escola Secundária Dr. João de Araújo Correia, no Peso da Régua. Neste âmbito, foi possível colocar em prática algumas modalidades do e–Learning e trabalhar com plataformas LMS e LCMS, para a gestão das aprendizagens e dos conteúdos lecionados. Neste contexto, procura-se contextualizar teoricamente e refletir sobre a implementação das tecnologias e a dinamização do e-Learning nas
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Sung, Woon Hee. "Classifying learning management platforms by examining features and educational affordances." Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-08-4278.

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Learning management systems(LMSs) have become one of the most common computer systems adopted at universities, colleges and distance learning organizations. In order to identify different features and accordance of each LMS, LMSs’ features were compared by using four different categories; communication tools, productivity and student involvement tools, course delivery tools, and administration tools. Based upon the comparison of the different features affecting different usage patterns, this paper proposes a classification of seven selected LMSs; ANGEL, Blackboard, Moodle, Sakai, WebCT, Ning a
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Yang, John. "Pharmacokinetics and cytoprotective evaluation of Caffeic Acid Phenethyl Amide and fluorinated derivatives against oxidative stress." 2012. http://hdl.handle.net/2152/19620.

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Ischemic injury occurs when the flow of blood is reduced or blocked to an area of the body and can cause significant tissue damage by generation of reactive oxygen species (ROS), activation of apoptotic pathways and through induction of the inflammatory response. Restoration of blood flow and reperfusion of the blocked site, while essential, can generate a second injury that itself needs to be controlled. Together the two injuries are termed ischemia/reperfusion (I/R) injury. This type of injury is frequently encountered in medicine and is a major medical problem. Therapeutic strategies to com
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