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Journal articles on the topic 'LCFAs'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

LOUET, Jean-Francç;ois, Florence CHATELAIN, Jean-Francç;ois DECAUX та ін. "Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway". Biochemical Journal 354, № 1 (2001): 189–97. http://dx.doi.org/10.1042/bj3540189.

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Liver carnitine palmitoyltransferase I (L-CPT I) catalyses the transfer of long-chain fatty acid (LCFA) for translocation across the mitochondrial membrane. Expression of the L-CPT I gene is induced by LCFAs as well as by lipid-lowering compounds such as clofibrate. Previous studies have suggested that the peroxisome-proliferator-activated receptor α (PPARα) is a common mediator of the transcriptional effects of LCFA and clofibrate. We found that free LCFAs rather than acyl-CoA esters are the signal metabolites responsible for the stimulation of L-CPT I gene expression. Using primary culture o

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Schaffer, Jean E. "Fatty acid transport: the roads taken." American Journal of Physiology-Endocrinology and Metabolism 282, no. 2 (2002): E239—E246. http://dx.doi.org/10.1152/ajpendo.00462.2001.

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Efficient uptake and channeling of long-chain fatty acids (LCFAs) are critical cellular functions. Although spontaneous flip-flop of nonionized LCFAs from one leaflet of a bilayer to the other is rapid, evidence is emerging that proteins are important mediators and/or regulators of trafficking of LCFAs into and within cells. Genetic screens have led to the identification of proteins that are required for fatty acid import and utilization in prokaryotic organisms. In addition, functional screens have elucidated proteins that facilitate fatty acid import into mammalian cells. Although the mechan

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Jay, Anthony G., Jeffrey R. Simard, Nasi Huang, and James A. Hamilton. "SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect FA translocation." Journal of Lipid Research 61, no. 5 (2020): 790–807. http://dx.doi.org/10.1194/jlr.ra120000648.

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Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric pH indicator (2′,7′-bis-(2-carboxyethyl)-5-(and-6-)-carboxyfluorescein and acrylodated intestinal FA-binding protein-based dual fluorescence assays, we investigated the effects of nine inhibitors of the putative FA transporter protein CD36 on the binding and transmembrane movement

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Dasa, Kris Triwulan, Supansa Y. Westman, Ria Millati, Muhammad Nur Cahyanto, Mohammad J. Taherzadeh, and Claes Niklasson. "Inhibitory Effect of Long-Chain Fatty Acids on Biogas Production and the Protective Effect of Membrane Bioreactor." BioMed Research International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/7263974.

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Anaerobic digestion of lipid-containing wastes for biogas production is often hampered by the inhibitory effect of long-chain fatty acids (LCFAs). In this study, the inhibitory effects of LCFAs (palmitic, stearic, and oleic acid) on biogas production as well as the protective effect of a membrane bioreactor (MBR) against LCFAs were examined in thermophilic batch digesters. The results showed that palmitic and oleic acid with concentrations of 3.0 and 4.5 g/L resulted in >50% inhibition on the biogas production, while stearic acid had an even stronger inhibitory effect. The encased cells in

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Felton, Erin, Aszia Burrell, Hollis Chaney, et al. "Inflammation in children with cystic fibrosis: contribution of bacterial production of long-chain fatty acids." Pediatric Research 90, no. 1 (2021): 99–108. http://dx.doi.org/10.1038/s41390-021-01419-4.

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Abstract Background Cystic fibrosis (CF) affects >70,000 people worldwide, yet the microbiologic trigger for pulmonary exacerbations (PExs) remains unknown. The objective of this study was to identify changes in bacterial metabolic pathways associated with clinical status. Methods Respiratory samples were collected at hospital admission for PEx, end of intravenous (IV) antibiotic treatment, and follow-up from 27 hospitalized children with CF. Bacterial DNA was extracted and shotgun DNA sequencing was performed. MetaPhlAn2 and HUMAnN2 were used to evaluate bacterial taxonomic and pathway rel

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Johnson, Erika Segear, Kelly R. Lindblom, Alexander Robeson, et al. "Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis." Journal of Biological Chemistry 288, no. 20 (2013): 14463–75. http://dx.doi.org/10.1074/jbc.m112.437210.

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The accumulation of long-chain fatty acids (LCFAs) in non-adipose tissues results in lipid-induced cytotoxicity (or lipoapoptosis). Lipoapoptosis has been proposed to play an important role in the pathogenesis of several metabolic diseases, including non-alcoholic fatty liver disease, diabetes mellitus, and cardiovascular disease. In this report, we demonstrate a novel role for caspase-2 as an initiator of lipoapoptosis. Using a metabolomics approach, we discovered that the activation of caspase-2, the initiator of apoptosis in Xenopus egg extracts, is associated with an accumulation of LCFA m

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Miller, Rhea M., Andrew P. Tomaras, Adam P. Barker, et al. "Pseudomonas aeruginosa Twitching Motility-Mediated Chemotaxis towards Phospholipids and Fatty Acids: Specificity and Metabolic Requirements." Journal of Bacteriology 190, no. 11 (2008): 4038–49. http://dx.doi.org/10.1128/jb.00129-08.

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ABSTRACT Pseudomonas aeruginosa demonstrates type IV pilus-mediated directional twitching motility up a gradient of phosphatidylethanolamine (PE). Only one of four extracellular phospholipases C of P. aeruginosa (i.e., PlcB), while not required for twitching motility per se, is required for twitching-mediated migration up a gradient of PE or phosphatidylcholine. Whether other lipid metabolism genes are associated with this behavior was assessed by analysis of transcription during twitching up a PE gradient in comparison to transcription during twitching in the absence of any externally applied

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ko, jaesung, Jae Moon Koh, Jae-Seon So, and Doo Hyun Chung. "Palmitic acid promotes t-bet and gata-3 mRNA degradation in NKT cells via regulated IRE1a-dependent decay." Journal of Immunology 198, no. 1_Supplement (2017): 75.3. http://dx.doi.org/10.4049/jimmunol.198.supp.75.3.

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Abstract Long chain fatty acids (LCFAs) exert pro-inflammatory effects in vivo. However, little is known regarding the effect of LCFAs on invariant (i) NKT cell functions. Here, we report an inhibitory effect of saturated LCFAs on transcription factors in iNKT cell. Among the saturated LCFAs, palmitic acid (PA) specifically inhibited IL-4 and IFN-g production and reduced gata-3 and t-bet transcript levels in iNKT cells during TCR-mediated activation. In iNKT cells, PA was localized and induced dilation in the endoplasmic reticulum and increased the mRNA levels of downstream molecules of IRE1 R

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Karasuta, Chayakorn, Supakorn Sirimittagoon, Ratchanon Chantanuson, and Varong Pavarajarn. "Effect of Type of Metals on Site Selective Dehydrogenation of Stearic Acid." MATEC Web of Conferences 333 (2021): 05001. http://dx.doi.org/10.1051/matecconf/202133305001.

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Short-chain fatty acids (SCFAs) have been used as raw materials in wide range of chemical and medical applications. One technique to produce SCFAs is oxidative cleavage of long-chain fatty acids (LCFAs). However, unless the LCFAs are unsaturated, the yield of SCFAs is often very low because the carboxylic group of the fatty acid is more active than other part of the molecule. This work explores the idea of introducing a double bond into saturated LCFA, i.e., stearic acid, via selective dehydrogenation using commercial heterogeneous catalysts. However, cracking of the LCFA is also catalysed. Di

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Karasuta, Chayakorn, Supakorn Sirimittagoon, Ratchanon Chantanuson, and Varong Pavarajarn. "Effect of Type of Metals on Site Selective Dehydrogenation of Stearic Acid." MATEC Web of Conferences 333 (2021): 05001. http://dx.doi.org/10.1051/matecconf/202133305001.

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Short-chain fatty acids (SCFAs) have been used as raw materials in wide range of chemical and medical applications. One technique to produce SCFAs is oxidative cleavage of long-chain fatty acids (LCFAs). However, unless the LCFAs are unsaturated, the yield of SCFAs is often very low because the carboxylic group of the fatty acid is more active than other part of the molecule. This work explores the idea of introducing a double bond into saturated LCFA, i.e., stearic acid, via selective dehydrogenation using commercial heterogeneous catalysts. However, cracking of the LCFA is also catalysed. Di

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Hatamoto, Masashi, Hiroyuki Imachi, Akiyoshi Ohashi, and Hideki Harada. "Identification and Cultivation of Anaerobic, Syntrophic Long-Chain Fatty Acid-Degrading Microbes from Mesophilic and Thermophilic Methanogenic Sludges." Applied and Environmental Microbiology 73, no. 4 (2006): 1332–40. http://dx.doi.org/10.1128/aem.02053-06.

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ABSTRACT We investigated long-chain fatty acid (LCFA)-degrading anaerobic microbes by enrichment, isolation, and RNA-based stable isotope probing (SIP). Primary enrichment cultures were made with each of four LCFA substrates (palmitate, stearate, oleate, or linoleate, as the sole energy source) at 55ï¿½C or 37ï¿½C with two sources of anaerobic granular sludge as the inoculum. After several transfers, we obtained seven stable enrichment cultures in which LCFAs were converted to methane. The bacterial populations in these cultures were then subjected to 16S rRNA gene-based cloning, in situ hybri

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Xiao, Xiaolan, Wansheng Shi, and Wenquan Ruan. "Effects of High Sludge Cycle Frequency on Performance and Syntrophic Metabolism of Anaerobic Membrane Bioreactor for Treating High-Lipid Kitchen Waste Slurry." Energies 12, no. 14 (2019): 2673. http://dx.doi.org/10.3390/en12142673.

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The performance and syntrophic metabolism of the Anaerobic Membrane Bio-reactor (AnMBR) treating high-lipid kitchen waste slurry under different sludge cycle frequencies were investigated in this study. When the sludge cycle frequencies were 3.6 cycles/h, 9.0 cycles/h and 14.4 cycles/h, the obtained Organic Loading Rates (OLRs) were 10.3 kg-COD/m3d, 12.4 kg-COD/m3d and 18.1 kg-COD/m3d, while the corresponding biogas productions were 190 L/d, 310 L/d and 520 L/d. Moreover, with an increase of sludge cycle frequency, the Chemical Oxygen Demand (COD) removal efficiency improved from 86.2% to 90.4

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Fanfoni, Elisabetta, Erika Sinisgalli, Alessandra Fontana, Mariangela Soldano, Mirco Garuti, and Lorenzo Morelli. "Microbial Characterisation of a Two-Stage Anaerobic Digestion Process for Conversion of Agri-Based Feedstock in Biogas and Long-Chain Fatty Acids in a Circular Economy Framework." Fermentation 10, no. 6 (2024): 293. http://dx.doi.org/10.3390/fermentation10060293.

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In addition to energy recovery, the anaerobic digestion of agro-industrial byproducts can also produce different high-value-added compounds. Two-stage and single-stage reactors were compared for microbial communities’ selection and long-chain fatty acid (LCFA) accumulation to investigate which microbial genera are most linked to the production of these compounds. The microbial communities present in the two reactors’ configuration in the steady state were characterised by 16S rRNA amplicon sequencing, while LCFAs were extracted and quantified from digestate samples by gas chromatography. The r

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Tenagy, Kengo Tejima, Xinyue Chen, Shun Iwatani, and Susumu Kajiwara. "Long-Chain Acyl-CoA Synthetase is Associated with the Growth of Malassezia spp." Journal of Fungi 5, no. 4 (2019): 88. http://dx.doi.org/10.3390/jof5040088.

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The lipophilic fungal pathogen Malassezia spp. must acquire long-chain fatty acids (LCFAs) from outside the cell. To clarify the mechanism of LCFA acquisition, we investigated fatty acid uptake by this fungus and identified the long-chain acyl-CoA synthetase (ACS) gene FAA1 in three Malassezia spp.: M. globosa, M. pachydermatis, and M. sympodialis. These FAA1 genes could compensate for the double mutation of FAA1 and FAA4 in Saccharomyces cerevisiae, suggesting that Malassezia Faa1 protein recognizes exogenous LCFAs. MgFaa1p and MpFaa1p utilized a medium-chain fatty acid, lauric acid (C12:0).

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Sakurai, Riku, Shuhei Takizawa, Yasuhiro Fukuda, and Chika Tada. "Exploration of microbial communities contributing to effective methane production from scum under anaerobic digestion." PLOS ONE 16, no. 9 (2021): e0257651. http://dx.doi.org/10.1371/journal.pone.0257651.

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Scum is formed by the adsorption of long-chain fatty acids (LCFAs) onto biomass surface in anaerobic digestion of oily substrates. Since scum is a recalcitrant substrate to be digested, it is disposed via landfilling or incineration, which results in biomass washout and a decrease in methane yield. The microbes contributing to scum degradation are unclear. This study aimed to investigate the cardinal microorganisms in anaerobic scum digestion. We pre-incubated a sludge with scum to enrich scum-degrading microbes. Using this sludge, a 1.3-times higher methane conversion rate (73%) and a faster

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Durgan, David J., Justin K. Smith, Margaret A. Hotze, et al. "Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 6 (2006): H2480—H2497. http://dx.doi.org/10.1152/ajpheart.01344.2005.

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The molecular mechanism(s) responsible for channeling long-chain fatty acids (LCFAs) into oxidative versus nonoxidative pathways is (are) poorly understood in the heart. Intracellular LCFAs are converted to long-chain fatty acyl-CoAs (LCFA-CoAs) by a family of long-chain acyl-CoA synthetases (ACSLs). Cytosolic thioesterase 1 (CTE1) hydrolyzes cytosolic LCFA-CoAs to LCFAs, generating a potential futile cycle at the expense of ATP utilization. We hypothesized that ACSL isoforms and CTE1 are differentially regulated in the heart during physiological and pathophysiological conditions. Using quanti

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Ma, Chunxiang, Reshma Vasu, and Hu Zhang. "The Role of Long-Chain Fatty Acids in Inflammatory Bowel Disease." Mediators of Inflammation 2019 (November 3, 2019): 1–10. http://dx.doi.org/10.1155/2019/8495913.

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Inflammatory bowel disease (IBD) is a complicated disease involving multiple pathogenic factors. The complex relationships between long-chain fatty acids (LCFAs) and the morbidity of IBD drive numerous studies to unravel the underlying mechanisms. A better understanding of the role of LCFAs in IBD will substitute or boost the current IBD therapies, thereby obtaining mucosal healing. In this review, we focused on the roles of LCFAs on the important links of inflammatory regulation in IBD, including in the pathogen recognition phase and in the inflammatory resolving phase, and the effects of LCF

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J., Kamishikiryo. "Differential Effects of 2 to16 Carbon Saturated Fatty Acids on Autophagy and Cell Viability of HepG2 Cells." International Journal of Pharmacy and Biological Sciences (IJPBS) 13, no. 2 (2023): 223–30. https://doi.org/10.5281/zenodo.10608294.

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AbstractDietary fat increases levels of saturated fatty acids (SFAs) in plasma, which exacerbate metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Palmitic acid, a long-chain SFA (LCFA), inhibits autophagy and causes apoptosis of hepatocytes. However, the effects of other SFAs on hepatocytes remain unknown. In this study, we explored how SFAs whose chain lengths range from 2- to 16-carbon atoms affect autophagy and cell viability of hepatocytes in vitro. Our results showed that only 14- and 16-carbon LCFAs suppress autophagy and reduce cell viability; 2- to 12-carbon SFAs, whic

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Wu, Jia-Qi, Xue-Ming Zhu, Jian-Dong Bao, et al. "The MoLfa1 Protein Regulates Fungal Development and Septin Ring Formation in Magnaporthe oryzae." International Journal of Molecular Sciences 25, no. 6 (2024): 3434. http://dx.doi.org/10.3390/ijms25063434.

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Septins play a key regulatory role in cell division, cytokinesis, and cell polar growth of the rice blast fungus (Magnaporthe oryzae). We found that the organization of the septin ring, which is essential for appressorium-mediated infection in M. oryzae, requires long-chain fatty acids (LCFAs), which act as mediators of septin organization at membrane interfaces. However, it is unclear how septin ring formation and LCFAs regulate the pathogenicity of the rice blast fungus. In this study, a novel protein was named MoLfa1 because of its role in LCFAs utilization. MoLfa1 affects the utilization o

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Akkaoui, Marie, Isabelle Cohen, Catherine Esnous, et al. "Modulation of the hepatic malonyl-CoA–carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids1." Biochemical Journal 420, no. 3 (2009): 429–38. http://dx.doi.org/10.1042/bj20081932.

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Liver mitochondrial β-oxidation of LCFAs (long-chain fatty acids) is tightly regulated through inhibition of CPT1A (carnitine palmitoyltransferase 1A) by malonyl-CoA, an intermediate of lipogenesis stimulated by glucose and insulin. Moreover, CPT1A sensitivity to malonyl-CoA inhibition varies markedly depending on the physiopathological state of the animal. In the present study, we asked whether an increase in CPT1A activity solely or in association with a decreased malonyl-CoA sensitivity could, even in the presence of high glucose and insulin concentrations, maintain a sustained LCFA β-oxida

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Duchaine, Caroline, Pierre-Hugues Carmichael, Nancy Presse, et al. "Plasma Long Chain Fatty Acids and Cognitive Function in Older Adults: A Comparison of Statistical Analyses." Innovation in Aging 5, Supplement_1 (2021): 13. http://dx.doi.org/10.1093/geroni/igab046.048.

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Abstract Omega-3 fatty acids (FAs) have been suggested as modifiable protective factors for cognitive decline because of their neuroprotective properties. However, the evidence is still inconsistent regarding types of omega-3 FAs, and the probable interrelation with other circulating long chain FAs (LCFAs). This study aimed to evaluate associations between 14 plasma LCFAs and four cognitive domains using a principal component analysis (PCA) and to compare results with those obtained using standard methods. A group of 386 healthy older adults aged 77 ± 4 years (53% women), selected from the Nut

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Valdez-Salazar, Hilda A., Miguel A. Ares, Francisco J. Fernández, et al. "Long-chain fatty acids alter transcription of Helicobacter pylori virulence and regulatory genes." PeerJ 9 (November 1, 2021): e12270. http://dx.doi.org/10.7717/peerj.12270.

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Infection with Helicobacter pylori is one of the most important risk factors for developing gastric cancer (GC). The type IV secretion system (T4SS) encoded in the cag pathogenicity island is the main virulence factor of H. pylori associated with GC. Additionally, other virulence factors have been shown to play a role in the H. pylori virulence, such as vacuolizing cytotoxin (VacA), urease, flagella, and adhesins. Long-chain fatty acids (LCFAs) are signaling molecules that affect the transcription of virulence genes in several pathogenic bacteria such as Salmonella enterica, Vibrio cholerae, P

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Ajie, H. O., M. J. Connor, W. N. Lee, S. Bassilian, E. A. Bergner, and L. O. Byerley. "In vivo study of the biosynthesis of long-chain fatty acids using deuterated water." American Journal of Physiology-Endocrinology and Metabolism 269, no. 2 (1995): E247—E252. http://dx.doi.org/10.1152/ajpendo.1995.269.2.e247.

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To determine the contributions of preexisting fatty acid, de novo synthesis, and chain elongation in long-chain fatty acid (LCFA) synthesis, the synthesis of LCFAs, palmitate (16:0), stearate (18:0), arachidate (20:0), behenate (22:0), and lignocerate (24:0), in the epidermis, liver, and spinal cord was determined using deuterated water and mass isotopomer distribution analysis in hairless mice and Sprague-Dawley rats. Animals were given 4% deuterated water for 5 days or 8 wk in their drinking water. Blood was withdrawn at the end of these times for the determination of deuterium enrichment, a

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Manzo, Teresa, Carina Nava Lauveson, Teresa Maria Frasconi, et al. "668 Lipid-instructed metabolic rewiring unleash the anti-tumor potential of CD8+ T cells." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A696. http://dx.doi.org/10.1136/jitc-2021-sitc2021.668.

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BackgroundAdoptive cell therapy (ACT) harnesses the immune system to recognise tumor cells and carry out an anti-tumor function. However, metabolic constraints imposed by the tumour microenvironment (TME) suppress anti-tumor responses of CTL by reshaping their metabolism and epigenetic landscape. We have recently demonstrated that progressive accumulation of specific long-chain fatty acids (LCFAs) impair mitochondrial function and drives CD8+ T cell dysfunction. In this scenario, maintaining T cells in a less-differentiated state and with high metabolic plasticity during ex vivo T cell product

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Luiken, Joost J. F. P., Jan F. C. Glatz, and Arend Bonen. "Fatty Acid Transport Proteins Facilitate Fatty Acid Uptake in Skeletal Muscle." Canadian Journal of Applied Physiology 25, no. 5 (2000): 353–412. http://dx.doi.org/10.1139/h00-026.

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In view of the importance of long chain fatty acids (LCFAs) to many cellular processes, it may be desirable to regulate the LCFA disposition in the cell. Such regulation may be present at the level of the plasma membrane, since a number of putative LCFA transport proteins have been cloned. The development of a model system of giant vesicles has proven to be important in identifying the metabolic role of the LCFA transport system. LCFA transport rates and transporters (FABPpm and FAT/CD36) are scaled with oxidative capacity of heart and muscle. FAT/CD36 is a critical LCFA transport protein in m

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TEBOUL, Lydia, Maria FEBBRAIO, Danielle GAILLARD, Ez-Zoubir AMRI, Roy SILVERSTEIN, and Paul A. GRIMALDI. "Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation." Biochemical Journal 360, no. 2 (2001): 305–12. http://dx.doi.org/10.1042/bj3600305.

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Fatty acid translocase (FAT/CD36) is a cell-surface glycoprotein that functions as a receptor/transporter for long-chain fatty acids (LCFAs), and interacts with other protein and lipid ligands. FAT/CD36 is expressed by various cell types, including platelets, monocytes/macrophages and endothelial cells, and tissues with an active LCFA metabolism, such as adipose, small intestine and heart. FAT/CD36 expression is induced during adipose cell differentiation and is transcriptionally up-regulated by LCFAs and thiazolidinediones in pre-adipocytes via a peroxisome-proliferator-activated receptor (PP

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de Kluijver, Anna, Klaas G. J. Nierop, Teresa M. Morganti, et al. "Bacterial precursors and unsaturated long-chain fatty acids are biomarkers of North-Atlantic deep-sea demosponges." PLOS ONE 16, no. 1 (2021): e0241095. http://dx.doi.org/10.1371/journal.pone.0241095.

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Sponges produce distinct fatty acids (FAs) that (potentially) can be used as chemotaxonomic and ecological biomarkers to study endosymbiont-host interactions and the functional ecology of sponges. Here, we present FA profiles of five common habitat-building deep-sea sponges (class Demospongiae, order Tetractinellida), which are classified as high microbial abundance (HMA) species. Geodia hentscheli, G. parva, G. atlantica, G. barretti, and Stelletta rhaphidiophora were collected from boreal and Arctic sponge grounds in the North-Atlantic Ocean. Bacterial FAs dominated in all five species and p

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Sahlin, Kent. "Control of lipid oxidation at the mitochondrial levelThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process." Applied Physiology, Nutrition, and Metabolism 34, no. 3 (2009): 382–88. http://dx.doi.org/10.1139/h09-027.

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The rate of lipid oxidation during exercise is controlled at several sites, and there is a reciprocal dependency between oxidation of lipids and carbohydrates (CHO). It is well known that the proportion of the 2 fuels oxidized is influenced by substrate availability and exercise intensity, but the mechanisms regulating fuel preferences remain unclear. During intense exercise, oxidation of long-chain fatty acids (LCFAs) decreases, and the major control is likely to be at the mitochondrial level. Potential mitochondrial sites for control of lipid oxidation include transport of LCFAs into mitocho

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Ogata, Ruiko, Yi Luo, Rina Fujiwara-Tani, et al. "Long-Chain Fatty Acids Alter Estrogen Receptor Expression in Breast Cancer Cells." International Journal of Molecular Sciences 26, no. 14 (2025): 6722. https://doi.org/10.3390/ijms26146722.

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Long-chain fatty acids (LCFAs) have emerged as important regulators of cancer metabolism, but their impact on hormone receptor expression in breast cancer (BCA) remains poorly understood. In this study, we investigated the effects of five LCFAs—linoleic acid (LA), oleic acid (OA), elaidic acid (EA), palmitic acid (PA), and α-linolenic acid (LNA)—on two BCA cell lines: luminal-type MCF7 and triple-negative MDA-MB-231 (MB231). All LCFAs suppressed cell viability and mitochondrial function in a dose-dependent manner, accompanied by decreased membrane potential, increased reactive oxygen species p

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Piccirillo, Ann, William F. Hawse, Ashley V. Menk, et al. "The role of LPC and lipid transporter MFSD2A in CD8 T cells." Journal of Immunology 198, no. 1_Supplement (2017): 121.2. http://dx.doi.org/10.4049/jimmunol.198.supp.121.2.

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Abstract Little is known about how effector CD8 T cells obtain exogenous long chain fatty acids (LCFAs) during T cell activation. LCFAs assist with membrane biogenesis and are required for rapid proliferation as well as effector molecule generation. One potential mechanism of fatty acid import is in the form of lysophophatidylcholine (LPC) by lipid carrier major facilitator superfamily domain containing 2a (MFSD2A). Here, we show that MFSD2A is highly expressed in activated CD8 T cells. Conditional loss of MFSD2A caused an altered effector response and resulted in defective memory cell formati

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Palmer, Nicholette D., Hayrettin Okut, Fang-Chi Hsu, et al. "Metabolomics Identifies Distinctive Metabolite Signatures for Measures of Glucose Homeostasis: The Insulin Resistance Atherosclerosis Family Study (IRAS-FS)." Journal of Clinical Endocrinology & Metabolism 103, no. 5 (2018): 1877–88. http://dx.doi.org/10.1210/jc.2017-02203.

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Abstract Context Metabolomics provides a biochemical fingerprint that, when coupled with clinical phenotypes, can provide insight into physiological processes. Objective Survey metabolites associated with dynamic and basal measures of glucose homeostasis. Design Analysis of 733 plasma metabolites from the Insulin Resistance Atherosclerosis Family Study. Setting Community based. Participants One thousand one hundred eleven Mexican Americans. Main Outcome Dynamic measures were obtained from the frequently sampled intravenous glucose tolerance test and included insulin sensitivity and acute insul

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Storey, Stephen M., Avery L. McIntosh, Huan Huang, et al. "Loss of intracellular lipid binding proteins differentially impacts saturated fatty acid uptake and nuclear targeting in mouse hepatocytes." American Journal of Physiology-Gastrointestinal and Liver Physiology 303, no. 7 (2012): G837—G850. http://dx.doi.org/10.1152/ajpgi.00489.2011.

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The liver expresses high levels of two proteins with high affinity for long-chain fatty acids (LCFAs): liver fatty acid binding protein (L-FABP) and sterol carrier protein-2 (SCP-2). Real-time confocal microscopy of cultured primary hepatocytes from gene-ablated (L-FABP, SCP-2/SCP-x, and L-FABP/SCP-2/SCP-x null) mice showed that the loss of L-FABP reduced cellular uptake of 12- N-methyl-(7-nitrobenz-2-oxa-1,3-diazo)-aminostearic acid (a fluorescent-saturated LCFA analog) by ∼50%. Importantly, nuclear targeting of the LCFA was enhanced when L-FABP was upregulated (SCP-2/SCP-x null) but was sign

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Liu, Jun-Chang, Huan Yu, Rui Li, et al. "A Preliminary Comparison of Plasma Tryptophan Metabolites and Medium- and Long-Chain Fatty Acids in Adult Patients with Major Depressive Disorder and Schizophrenia." Medicina 59, no. 2 (2023): 413. http://dx.doi.org/10.3390/medicina59020413.

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Background and Objectives: Disturbance of tryptophan (Trp) and fatty acid (FA) metabolism plays a role in the pathogenesis of psychiatric disorders. However, quantitative analysis and comparison of plasma Trp metabolites and medium- and long-chain fatty acids (MCFAs and LCFAs) in adult patients with major depressive disorder (MDD) and schizophrenia (SCH) are limited. Materials and Methods: Clinical symptoms were assessed and the level of Trp metabolites and MCFAs and LCFAs for plasma samples from patients with MDD (n = 24) or SCH (n = 22) and healthy controls (HC, n = 23) were obtained and ana

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Wu, Qiwei, Angelica M. Ortegon, Bernice Tsang, Holger Doege, Kenneth R. Feingold, and Andreas Stahl. "FATP1 Is an Insulin-Sensitive Fatty Acid Transporter Involved in Diet-Induced Obesity." Molecular and Cellular Biology 26, no. 9 (2006): 3455–67. http://dx.doi.org/10.1128/mcb.26.9.3455-3467.2006.

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ABSTRACT Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues. In adipocytes and skeletal muscle, FATP1 translocates from an intracellular compartment to the plasma membrane in response to insulin. Here we show that insulin-stimulated fatty acid uptake is completely abolished in FATP1-null adipocytes and greatly reduced in skeletal muscle of FATP1-knockout animals while basal LCFA uptake by both tissues was unaffected. Moreover, loss of FATP1 functi

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de, Kluijver Anna, Klaas GJ Nierop, Teresa M. Morganti, et al. "Bacterial precursors and unsaturated long-chain fatty acids are biomarkers of North-Atlantic demosponges." Plos ONE 16, no. 1 (2021): e0241095. https://doi.org/10.1371/journal.pone.0241095.

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ABSTRACT Sponges produce distinct fatty acids (FAs) that (potentially) can be used as chemotaxonomic and ecological biomarkers to study endosymbiont-host interactions and the functional ecology of sponges. Here, we present FA profiles of five common habitat-building deep-sea sponges (class Demospongiae, order Tetractinellida), which are classified as high microbial abundance (HMA) species. <em>Geodia hentscheli</em>, <em>G. parva</em>, <em>G. atlantica</em>, <em>G. barretti,</em> and <em>Stelletta rhaphidiophora</em> were collected from boreal and Arctic spon

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Liu, Tong, Inci Dogan, Michael Rothe, et al. "Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis." Metabolites 12, no. 3 (2022): 269. http://dx.doi.org/10.3390/metabo12030269.

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Long-chain fatty acids (LCFAs) serve as energy sources, components of cell membranes, and precursors for signaling molecules. Uremia alters LCFA metabolism so that the risk of cardiovascular events in chronic kidney disease (CKD) is increased. End-stage renal disease (ESRD) patients undergoing dialysis are particularly affected and their hemodialysis (HD) treatment could influence blood LCFA bioaccumulation and transformation. We investigated blood LCFA in HD patients and studied LCFA profiles in vivo by analyzing arterio–venous (A–V) LFCA differences in upper limbs. We collected arterial and

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Sousa, Diana Z., M. Alcina Pereira, Alfons J. M. Stams, M. Madalena Alves, and Hauke Smidt. "Microbial Communities Involved in Anaerobic Degradation of Unsaturated or Saturated Long-Chain Fatty Acids." Applied and Environmental Microbiology 73, no. 4 (2006): 1054–64. http://dx.doi.org/10.1128/aem.01723-06.

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ABSTRACTAnaerobic long-chain fatty acid (LCFA)-degrading bacteria were identified by combining selective enrichment studies with molecular approaches. Two distinct enrichment cultures growing on unsaturated and saturated LCFAs were obtained by successive transfers in medium containing oleate and palmitate, respectively, as the sole carbon and energy sources. Changes in the microbial composition during enrichment were analyzed by denaturing gradient gel electrophoresis (DGGE) profiling of PCR-amplified 16S rRNA gene fragments. Prominent DGGE bands of the enrichment cultures were identified by 1

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Yang, Chun-Pai, Ching-Mao Chang, Cheng-Chia Yang, Carmine M. Pariante, and Kuan-Pin Su. "Long COVID and long chain fatty acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19." Brain, Behavior, and Immunity 103 (July 2022): 19–27. http://dx.doi.org/10.1016/j.bbi.2022.04.001.

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Mikłosz, Agnieszka, Bartłomiej Łukaszuk, Elżbieta Supruniuk, et al. "Does TBC1D4 (AS160) or TBC1D1 Deficiency Affect the Expression of Fatty Acid Handling Proteins in the Adipocytes Differentiated from Human Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Obtained from Subcutaneous and Visceral Fat Depots?" Cells 10, no. 6 (2021): 1515. http://dx.doi.org/10.3390/cells10061515.

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TBC1D4 (AS160) and TBC1D1 are Rab GTPase-activating proteins that play a key role in the regulation of glucose and possibly the transport of long chain fatty acids (LCFAs) into muscle and fat cells. Knockdown (KD) of TBC1D4 increased CD36/SR-B2 and FABPpm protein expressions in L6 myotubes, whereas in murine cardiomyocytes, TBC1D4 deficiency led to a redistribution of CD36/SR-B2 to the sarcolemma. In our study, we investigated the previously unexplored role of both Rab-GAPs in LCFAs uptake in human adipocytes differentiated from the ADMSCs of subcutaneous and visceral adipose tissue origin. To

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POIRIER, Hélène, Isabelle NIOT, Marie-Claude MONNOT та ін. "Differential involvement of peroxisome-proliferator-activated receptors α and δ in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine". Biochemical Journal 355, № 2 (2001): 481–88. http://dx.doi.org/10.1042/bj3550481.

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Liver fatty-acid-binding protein (L-FABP) is a cytoplasmic polypeptide that binds with strong affinity especially to long-chain fatty acids (LCFAs). It is highly expressed in both the liver and small intestine, where it is thought to have an essential role in the control of the cellular fatty acid (FA) flux. Because expression of the gene encoding L-FABP is increased by both fibrate hypolipidaemic drugs and LCFAs, it seems to be under the control of transcription factors, termed peroxisome-proliferator-activated receptors (PPARs), activated by fibrate or FAs. However, the precise molecular mec

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Holloway, Graham Paul. "The role of protein-mediated transport in regulating mitochondrial long-chain fatty acid oxidation." Applied Physiology, Nutrition, and Metabolism 33, no. 1 (2008): 141–42. http://dx.doi.org/10.1139/h07-172.

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This thesis is an investigation of the role of fatty acid translocase (FAT/CD36), plasma membrane associated fatty acid binding protein (FABPpm), and carnitine palmitoyltransferase I (CPTI) in transporting long-chain fatty acids (LCFAs) across mitochondrial membranes. Maximal CPTI activity, as well as the sensitivity of CPTI for its substrate palmitoyl-CoA (P-CoA) and its inhibitor malonyl-CoA (M-CoA), were measured in mitochondria isolated from human vastus lateralis muscles at rest and following muscle contraction. Exercise did not alter maximal CPTI activity or the sensitivity of CPTI for P

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Lu, Xinping, Xilin Zhao, Jianying Feng, et al. "Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 303, no. 3 (2012): G367—G376. http://dx.doi.org/10.1152/ajpgi.00541.2011.

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Ghrelin is a gastric peptide hormone that controls appetite and energy homeostasis. Plasma ghrelin levels rise before a meal and fall quickly thereafter. Elucidation of the regulation of ghrelin secretion has been hampered by the difficulty of directly interrogating ghrelin cells diffusely scattered within the complex gastric mucosa. Therefore, we generated transgenic mice with ghrelin cell expression of green fluorescent protein (GFP) to enable characterization of ghrelin secretion in a pure population of isolated gastric ghrelin-expressing GFP (Ghr-GFP) cells. Using quantitative RT-PCR and i

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Koonen, Debby P. Y., Carley R. Benton, Yoga Arumugam, et al. "Different mechanisms can alter fatty acid transport when muscle contractile activity is chronically altered." American Journal of Physiology-Endocrinology and Metabolism 286, no. 6 (2004): E1042—E1049. http://dx.doi.org/10.1152/ajpendo.00531.2003.

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We examined whether skeletal muscle transport rates of long-chain fatty acids (LCFAs) were altered when muscle activity was eliminated (denervation) or increased (chronic stimulation). After 7 days of chronically stimulating the hindlimb muscles of female Sprague-Dawley rats, the LCFA transporter proteins fatty acid translocase (FAT)/CD36 (+43%) and plasma membrane-associated fatty acid-binding protein (FABPpm; +30%) were increased ( P < 0.05), which resulted in the increased plasmalemmal content of these proteins (FAT/CD36, +42%; FABPpm +13%, P < 0.05) and a concomitant increase in the

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Gerrard, Samuel D., Fernando H. Biase, Joseph A. Yonke, et al. "Non-Alcoholic Fatty Liver Disease Induced by Feeding Medium-Chain Fatty Acids Upregulates Cholesterol and Lipid Homeostatic Genes in Skeletal Muscle of Neonatal Pigs." Metabolites 14, no. 7 (2024): 384. http://dx.doi.org/10.3390/metabo14070384.

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Non-alcoholic fatty liver disease (NAFLD) is a range of disorders characterized by lipid accumulation in hepatocytes. Although this spectrum of disorders is associated with adult obesity, recent evidence suggests that this condition could also occur independently of obesity, even in children. Previously, we reported that pigs fed a formula containing medium-chain fatty acids (MCFAs) developed hepatic steatosis and weighed less than those fed an isocaloric formula containing long-chain fatty acids (LCFAs). Our objective was to determine the association between NAFLD and the skeletal muscle tran

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Intarasuk, Chayut, Varong Pavarajarn, Supakorn Sirimittagoon, and Ratchanon Chantanuson. "Selective Oxidative Cleavage of Oleic Acid on Alumina Supported Metal Catalyst." MATEC Web of Conferences 333 (2021): 05002. http://dx.doi.org/10.1051/matecconf/202133305002.

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Short-chain fatty acids (SCFAs) and medium-chain fatty acid (MCFAs) are valuable raw materials in wide range of chemical and medical applications. They can be converted to other derivatives by known chemical reactions. Unfortunately, both SCFAs MCFAs are not as abundant in nature as long-chain fatty acid (LCFAs). In this work, the oxidative cleavage of oleic acid, which is one of the most abundant unsaturated LCFAs in nature, was studied. The oxidation was induced by hydrogen peroxide catalyzed by a commercial alumina-supported metal catalyst. The products were analyzed by gas chromatography e

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Intarasuk, Chayut, Varong Pavarajarn, Supakorn Sirimittagoon, and Ratchanon Chantanuson. "Selective Oxidative Cleavage of Oleic Acid on Alumina Supported Metal Catalyst." MATEC Web of Conferences 333 (2021): 05002. http://dx.doi.org/10.1051/matecconf/202133305002.

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Short-chain fatty acids (SCFAs) and medium-chain fatty acid (MCFAs) are valuable raw materials in wide range of chemical and medical applications. They can be converted to other derivatives by known chemical reactions. Unfortunately, both SCFAs MCFAs are not as abundant in nature as long-chain fatty acid (LCFAs). In this work, the oxidative cleavage of oleic acid, which is one of the most abundant unsaturated LCFAs in nature, was studied. The oxidation was induced by hydrogen peroxide catalyzed by a commercial alumina-supported metal catalyst. The products were analyzed by gas chromatography e

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He, Xia, and Tao Yan. "Impact of microbial activities and hydraulic retention time on the production and profile of long chain fatty acids in grease interceptors: a laboratory study." Environmental Science: Water Research & Technology 2, no. 3 (2016): 474–82. http://dx.doi.org/10.1039/c6ew00013d.

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Fat, oil and grease (FOG) deposits are a major cause of sanitary sewer overflows (SSOs), and calcium salts of long chain fatty acids (LCFAs) have recently been identified as key components of FOG deposits in sewer systems.

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Li, Jing, Srikant Viswanadha, and Juan J. Loor. "Hepatic Metabolic, Inflammatory, and Stress-Related Gene Expression in Growing Mice Consuming a Low Dose ofTrans-10,cis-12-Conjugated Linoleic Acid." Journal of Lipids 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/571281.

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Dietarytrans-10,cis-12-conjugated linoleic acid (trans-10,cis-12-CLA) fed to obese and nonobese rodents reduces body fat but leads to greater liver mass due to steatosis. The molecular mechanisms accompanying such responses remain largely unknown. Our study investigated the effects of chronic lowtrans-10,cis-12-CLA supplementation on hepatic expression of 39 genes related to metabolism, inflammation, and stress in growing mice. Feeding a diet supplemented with 0.3%trans-10,cis-12-CLA (wt/wt basis) for 6 weeks increased liver mass and concentration of long-chain fatty acids (LCFAs) in liver, wh

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Edmund, Sara J., and Beth Ann Heuer. "Metabolic myopathies series part 1: What we need to know." Journal of the American Association of Nurse Practitioners 37, no. 2 (2025): 85–87. https://doi.org/10.1097/jxx.0000000000001103.

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ABSTRACT Metabolic myopathies, a group of genetic disorders characterized by disruptions in muscle cell pathways, often lead to significant muscle fatigue. The potential underdiagnosis of these conditions is a concern because it can lead to long-term complications. Nurse practitioners are in a prime position to identify and refer these patients, thereby preventing such sequelae. Three genetic disorders affecting muscle metabolism include McArdle disease, Tarui disease, and carnitine palmitoyltransferase II deficiency. McArdle disease is a glycogen storage disease caused by a flaw in the produc

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Kawabata, Masato, and Rachel Evans. "How to Classify Who Experienced Flow from Who Did Not Based on the Flow State Scale-2 Scores: A Pilot Study of Latent Class Factor Analysis." Sport Psychologist 30, no. 3 (2016): 267–75. http://dx.doi.org/10.1123/tsp.2014-0053.

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The present study examined the extent to which scores on the Flow State Scale-2 (FSS-2) could differentiate individuals who experienced flow characteristics in physical activity from those who did not. A total of 1,048 participants completed the Japanese version of the FSS-2. Latent class factor analysis (LCFA), which combines the strengths of both latent class analysis and factor analysis, was conducted on the FSS-2 responses. Four classes were identified through a series of LCFAs and the patterns of the item-average scores for the nine flow attributes were found parallel among these classes.

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