Relevant bibliographies by topics / LD50 dose

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Academic literature on the topic 'LD50 dose'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "LD50 dose"

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Ordóñez-García, Magali, Juan Carlos Bustillos-Rodríguez, José de Jesús Ornelas-Paz, et al. "The Individual and Combined Entomopathogenic Activity of a Spodoptera frugiperda Multiple Nucleopolyhedrovirus and a Type I Spodoptera frugiperda Granulovirus on S. frugiperda Larvae." Viruses 17, no. 5 (2025): 674. https://doi.org/10.3390/v17050674.

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The bioinsecticidal activity of several doses of a Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV-CH-32; LD10, LD50, and LD90) and a Type I Spodoptera frugiperda granulovirus (SfGV-CH13; LD50 and LD90), alone and in co-infection, was evaluated on S. frugiperda larvae. In the co-infection assays, one virus was applied at 0 h, and then the second virus was supplied at different times (0, 12, and 24 h) in order to test the effect of the co-infection time on the insecticidal activity of the viruses. The symptoms observed in the co-infected larvae depended on the viral dose supplied at
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Shadrin, P. V., T. A. Batuashvili, L. V. Simutenko, and N. P. Neugodova. "Calculation of the Median Lethal Dose and Low Lethal Dose Using the CombiStats Biometric Software." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 11, no. 2 (2021): 135–42. http://dx.doi.org/10.30895/1991-2919-2021-11-2-135-142.

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The median lethal dose (LD50) and low lethal dose (LD10) are calculated in acute toxicity studies, as well as during specific activity assessment of some medicines. The aim of the study was to develop a procedure for using CombiStats to calculate LD50 and LD10. The authors proposed a step-by-step algorithm for processing bioassay results using the CombiStats biometric software (median effective dose determination model, probit analysis) with conversion of doses to simple fractions (fractions of the maximum dose) to calculate LD50 and LD10. They compared LD50 and LD10 calculation results obtain
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Makhziah, Makhziah, and Djarwatiningsih Poengky Soedjarwo. "Radiosensitivity of Two Local Chili Varieties to Gamma Rays." Jurnal Teknik Pertanian Lampung (Journal of Agricultural Engineering) 12, no. 2 (2023): 423. http://dx.doi.org/10.23960/jtep-l.v12i2.423-430.

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Genetic variation is needed for developing new superior varieties in plant breeding. Genetic variation of chili plants could be increased by inducing mutation with gamma rays irradiation. The aim of this study was to determine radiosensitivity of two local varieties of chili pepper by calculating the lethal dose values at LD20 and LD50. Chili pepper (Capsicum frutescens L.) seeds of local varieties origin from Tulungagung and Ponorogo were irradiated with cobalt-60 gamma rays at doses of: 0; 100; 200; 300; 400; 500; 600; 700; 800; 900; 1000 Gray (Gy); each as many as 50 seeds per dose of radia
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Shadrin, P. V. "Evaluation of the Possibility of Calculating LD50 and LD10 Using a Modified Script in the R Environment." Regulatory Research and Medicine Evaluation 15, no. 2 (2025): 213–21. https://doi.org/10.30895/1991-2919-2025-15-2-213-221.

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INTRODUCTION. The median lethal dose (LD50) and the low lethal dose (LD10) are critical parameters for the safety of medicinal products. Sometimes, the pharmacopoeial probit method (PM) fails to calculate the LD10 value, and the calculation result is obviously lower than the true value. In such cases, the use of other computational techniques is warranted.AIM. This study aimed to evaluate the potential of a script in the R environment as a tool for calculating the LD50 and LD10 of medicines.MATERIALS AND METHODS. This study compared the results of determining LD50 and LD10 using the spreadshee
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Li, Yao, Yingnan Wang, Chenglong Qian, et al. "Lethal and Sublethal Effects of Fluxametamide on Rice-Boring Pest, Rice Stem Borer Chilo suppressalis." Agronomy 12, no. 10 (2022): 2429. http://dx.doi.org/10.3390/agronomy12102429.

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(1) Background: Fluxametamide is a novel isoxazoline insecticide. Rice stem borer Chilo suppressalis (Walker) is a destructive Lepidoptera pest of rice in China, and novel effective insecticides are required to be developed for controlling it due to its increasing resistance levels. (2) Results: In the lethal assay, the insecticidal activity of fluxametamide with median lethal dose (LD50) value of 1.308 mg/kg to the fourth-instar larvae of C. suppressalis was higher than that of chlorantraniliprole (LD50, 3.112 mg/kg) and lower than that of emamectin benzoate (LD50, 0.006 mg/kg). In the sublet
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Siswanto, Eko. "CO60 dose and dose rate’s effects on Edamame Ryoko Jember variety’s growth and production." Interdisciplinary Social Studies 3, no. 3 (2024): 141–53. http://dx.doi.org/10.55324/iss.v3i3.656.

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Edamame is a famous type of soybean plant in Japan, edamme is often also referred to as Japanese soybeans. The purpose of this study was to determine the Lethal Dose 20 (LD20) and lethal dose 50 (LD50) radiosensitivity measurements in ryoko varieties originating from Jember which have been irradiated by Cobalt60 gamma rays in BATAN, with 5 dose levels including, 100 Gy, 200 Gy, 300 Gy, 400 Gy, and 500 Gy with Gammacell220. Edamame plants of the Jember Local Varieties were treated with a radiation dose of 200 Gy and a dose of 400 Gy. The plant height, number of pods, and weight of 100 seeds wer
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Siroki, Olga, L. Institoris, E. Tatar, and I. Desi. "lmmunotoxicological Investigation of SCMF, a New Pyrethroid Pesticide in Mice." Human & Experimental Toxicology 13, no. 5 (1994): 337–43. http://dx.doi.org/10.1177/096032719401300509.

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The toxicity of a new pyrethroid pesticide Supercypermethrin Forte (SCMF) was studied in male CFLP mice using classic toxicological (body weight, organ weights) and haematological (white blood cell count, haematocrit, nucleated cell content of femoral bone marrow) methods and immune function tests (PFC assay, DTH reaction). Four weeks of oral treatment in a 5 days per week system at doses of 1/10, 1/20, or 1/40 x LD50 did not cause evaluable changes in the measured parameters. When single calculated LD20, LD10, or LD5 doses of SCMF were administered on different days before termination to diff
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Hyellavala, Joseph Fomnya. "Phytochemical Analysis and Acute Toxicity Studies on the Methanol Extract of Securidaca longepedunculata (Fresen) Root Bark in Mice." Journal of Veterinary and Biomedical Sciences 3, no. 1 (2021): 41–48. http://dx.doi.org/10.36108/jvbs/1202.30.0160.

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The methanol extract of Securidaca longepedunculata root bark was screened phytochemically and its intraperitoneal acute toxicity evaluated in mice. The phytochemical screening was carried out based on standard methods. The Median Lethal Dose (LD50 ) was determined using Lorke’s method while the Maximum Tolerated Dose (LD0 ) was determined by the method described by Mosser and Padilla. The root bark extract revealed the presence of carbohydrates, terpenoids, cardiac glycosides, saponins and flavonoids. The extract produced intraperitoneal LD0 and LD50 values of 6.92 mg/kg and 6.0 mg/kg, respec
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Azzahra, Elmi Irmayanti, Syarifah Iis Aisyah, Diny Dinarti, and Krisantini Krisantini. "In Vitro Mutagenesis of Etlingera elatior by Gamma Ray Intermittent Irradiation." Journal of Tropical Crop Science 5, no. 3 (2018): 111–18. http://dx.doi.org/10.29244/jtcs.5.3.111-118.

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Etlingera elatior is tropical ornamental plant commonly called “torch ginger” from Zingiberaceae family. Conventional breeding of E. elatior is limited by cross incompatibility, poor fruit set and low seed production. In this study irradiation of E. elatior with Gamma ray performed to induce mutation. This study was aimed to increase morphological diversity and to obtain unique morphological characters to increase the aesthetic value of E. elatior as ornamental plants and cut flower. Two genotypes of E. elatior, red and white flowers, were tested. The LD20, LD35, and LD50 were determined follo
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Varlamova, O. V., A. V. Babkin, I. S. Berdinskih, A. K. Nazarov, A. S. Sadovnikova, and A. S. Nikiforov. "INVESTIGATION OF THE LEVEL OF GENE EXPRESSION OF SUBUNITS OF GABA RECEPTOR AFTER ADMINISTRATION OF KLOFLUBICIN." Toxicological Review, no. 5 (October 28, 2018): 33–37. http://dx.doi.org/10.36946/0869-7922-2018-5-33-37.

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The article presents the results of determining the level of expression of genes encoding GABA receptor subunits GABRA1, GABRB2, and GABRG2 in the hippocampus of rats 24 hours after a single intramuscular administration of the antagonist of the chloro-ion channel of GABA receptor of kloflubicin in a dose of LD25, LD40, LD50, and LD75. It is revealed that kloflubicin has no influence on the relative level of GABRG2 gene expression. At the same time, the relative level of GABRA1 gene expression increases 7,5, 7,0, and 5,0 times after administration of kloflubicin in a dose of LD40, LD50, and LD7
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Dissertations / Theses on the topic "LD50 dose"

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Lourenço, Clara Tavares. "Determinaçâo da toxicidade tópica e oral do inseticida fipronil e efeitos de suas doses subletais no comportamento de abelhas sem ferrão Melipona scutellaris (Latreille, 1811)." Universidade Federal de São Carlos, 2012. https://repositorio.ufscar.br/handle/ufscar/10.

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Made available in DSpace on 2016-06-02T18:55:23Z (GMT). No. of bitstreams: 1 4432.pdf: 1388434 bytes, checksum: d65f99bf92f697e1cf8e1d2b5a5fc2f9 (MD5) Previous issue date: 2012-05-09<br>Financiadora de Estudos e Projetos<br>Melipona scutellaris bee, known as "uruçu" belong to the tribe Meliponini, popularly called stingless bees. This bee is endemic in northeastern Brazil and is distinguished by its ease of domestication and management, significant honey production and potential for pollination in greenhouses and open field. The insecticide fipronil acts on the insect nervous system by block
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Books on the topic "LD50 dose"

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Clingerman, Karen J. The LD50 (median lethal dose) toxicity test, 1980-1988. U.S. Dept. of Agriculture, National Agricultural Library, 1989.

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Clingerman, Karen J. The LD50 (median lethal dose) toxicity test, 1980-1988. U.S. Dept. of Agriculture, National Agricultural Library, 1989.

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Clingerman, Karen J. The LD50 (median lethal dose) toxicity test, 1980-1988. U.S. Dept. of Agriculture, National Agricultural Library, 1989.

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Kreger, Michael D. The LD50 (median lethal dose) and LC50 (median lethal concentration) toxicity tests. National Agricultural Library, 1992.

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Kreger, Michael D. The LD50 (median lethal dose) and LC50 (median lethal concentration) toxicity tests. National Agricultural Library, 1992.

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Kreger, Michael D. The LD50 (median lethal dose) and LC50 (median lethal concentration) toxicity tests. National Agricultural Library, 1992.

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Clingerman, Karen J. The LD50 (median lethal dose) and LC50 (median lethal concentration) toxicity tests, January 1980 - August 1990. National Agricultural Library, 1990.

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Clingerman, Karen J. The LD50 (median lethal dose) and LC50 (median lethal concentration) toxicity tests, January 1980 - August 1990. National Agricultural Library, 1990.

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Clingerman, Karen J. The LD50 (median lethal dose) and LC50 (median lethal concentration) toxicity tests, January 1980 - August 1990. National Agricultural Library, 1990.

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Book chapters on the topic "LD50 dose"

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Datta, Subodh Kumar. "LD50 Dose." In Induced Mutation Breeding. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9489-0_7.

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Jankowicz-Cieslak, Joanna, Florian Goessnitzer, and Ivan L. W. Ingelbrecht. "Chemical Mutagenesis of Coffea arabica L. var. Venecia Cell Suspensions Using EMS." In Mutation Breeding in Coffee with Special Reference to Leaf Rust. Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-67273-0_8.

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AbstractArabica coffee is widely grown in Latin America where it is under threat of leaf rust, a fungal disease caused by Hemileia vastatrix. As a perennial crop, conventional breeding of Arabica coffee is challenged by its long juvenile period and narrow genetic base. Plant mutants are important resources for crop breeding and functional genomics studies. The ethylating agent ethyl methanesulfonate (EMS) is widely used for inducing random point mutations. In a wide range of species, treatment with EMS causes GC-to-AT transitions with great efficiency. These properties, combined with ease of u
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Gatica-Arias, Andrés, Jorge Rodríguez-Matamoros, Ana Abdelnour-Esquivel, and Marta Valdez-Melara. "Determination of the optimal conditions for mutagenesis induction in a commercial Arabica coffee variety." In Mutation breeding, genetic diversity and crop adaptation to climate change. CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0034.

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Abstract Low genetic diversity and autogamous reproduction limit genetic improvement of Coffea arabica L. As a consequence, susceptibility to biotic and abiotic stresses increases. Induced mutagenesis is an alternative strategy for increasing genetic variability and for the development of varieties tolerant or resistant to biotic and abiotic factors. In the present study, the effect of three mutagenic agents (NaN3, EMS and <sup>60</sup>Co gamma-rays) on survival of Arabica coffee zygotic embryos was evaluated. The zygotic embryos were immersed for 10 min in a solution of NaN3 (0, 2.5, 5.0, 7.5
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Bado, Souleymane, Fatemeh Maghuly, Vitor Varzea, and Margit Laimer. "Mutagenesis of in vitro explants of Coffea spp. to induce fungal resistance." In Mutation breeding, genetic diversity and crop adaptation to climate change. CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0036.

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Abstract Coffee is one of the most valuable commodity tree crops worldwide. However, it suffers from several devastating diseases and pests, for example coffee leaf rust and coffee berry borer, whose impact is being amplified by changing climatic conditions. Development of new adapted varieties remains a laborious effort by conventional breeding due to the long juvenile period in tree crops. Plant cell/tissue culture represents the ultimate method to produce large amounts of true-to-type healthy plants and of explants for mutation breeding. In fact, mutation induction combined with in vitro ce
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Choudhary, Shashi Bhushan, Anjay Kumar Jambhulkar, Hariom Kumar Sharma, A. Anil Kumar, Neetu Kumari, and Dileep Kumar. "Gamma-ray induced pedigreed mutant population of tossa jute (Corchorus olitorius L.): a key resource for forward and reverse genetics." In Mutation breeding, genetic diversity and crop adaptation to climate change. CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0048.

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Abstract Narrow genetic diversity in available germplasm is a serious limiting factor for academic progress and agronomic improvement of crops like Corchorus olitorius, an economically important bast fibre crop. Mutation breeding, with its proven ability to improve qualitative as well as quantitative traits, can be employed to augment germplasm diversity. In the present study, gamma-rays were used to treat the seeds of two promising varieties, JRO 204 and JRO 8432; LD50 doses for gamma-rays were 200 Gy and 300 Gy for JRO 204 and JRO 8432, respectively. Irradiation of two varieties has resulted
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"LD50 (Median Lethal Dose)." In Dictionary of Toxicology. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-9283-6_1509.

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Whitehead, A. "Statistical evaluation of the fixed-dose procedure." In Statistics in Toxicology. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780198523291.003.0010.

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Abstract The generally accepted method for assessing the acute oral toxicity of a substance has, until recently, been the LD50 study. In such a study, groups of laboratory animals, often rats, are given a range of dose levels of the substance, with the dose levels chosen to span the ‘expected’ median lethal dose (LD50). The internationally agreed guideline published by the Organization for Economic Co-operation and Development (OECD 1981) recommended that ten rats (five male and five female) be tested at each of a minimum of three dose levels. In 1987 the revised guideline (OECD 1987) reduced
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"The Median Lethal Dose (or LD50)." In Dictionary of Toxicology. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-9283-6_2660.

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Manukonda, Reethu Metilda. "Dose-Response Relationships." In Principles of Medical Toxicology. THINKPLUS PHARMA PUBLICATIONS, 2025. https://doi.org/10.69613/47m4mc24.

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Dose-response relationships represent the cornerstone of toxicological assessment, quantifying how biological systems react to varying exposure levels of toxic substances. These relationships help determine whether effects follow threshold or non-threshold models, with threshold responses occurring only above specific dose levels while non-threshold effects theoretically possible at any exposure. The concept of hormesis—where low doses produce opposite effects from high doses—further complicates these patterns. Toxicologists establish critical reference points including NOAEL (No-Observed-Adve
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Hemamalini, Dr K., Dr Sadanandam Palle, A. Pavithra, P. Pallavi, Mr Navadeep, and E. Harshavardan. "ANTI-DIARRHEAL ACTIVITY OF WHOLE PLANT OF ANNONA SQUMOSA." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 5. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn5ch5.

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The plant Annona squamosa belong to Annonaceae family was taken for the study. The methanolic extract of the whole plant extract was extracted and by continuous hot percolation process and the Phytochemical test was evaluated and then the extract was taken for the Antidiarrheal study with 400mg /kg as a dose after literature study and a trial for LD50 and Antidiarrheal activity was carried over by using castor oil induced diarrhea model which was compared with that of the standard loperamide with 5mg/kg body weight as dose. A significant decrease in the diarrhea was monitored and the same was
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Conference papers on the topic "LD50 dose"

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Cherkasova, E. E., G. V. Lavrentyeva, and B. I. Synzynys. "CALCULATION OF THE HALF-YEAR DOSE OF THE TERRESTRIAL MOLLUSK FRUTICICOLA FRUTICUM." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-1-325-328.

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The ecocentric strategy of radiation protection involves the expansion of experimental bases of radiation-induced effects in representatives of biota. This paper presents the calculated values of LD50/60 for the terrestrial mollusk F. fruticum after acute irradiation. To conduct a laboratory experiment, the conditions for keeping animals close to their natural habitat were selected. At the same time the mortality of mollusks in the control group remained at zero during the entire experiment. The calculated method of probit analysis using the least squares method was used to determine the LD50/
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S. Najm, Edrees. "Inference On Genetic Variation and Enzymatic Behavior of Callus in Two Sunflower Cultivars Induced by Ultraviolet Radiation." In XIII. International Scientific Congress of Pure, Applied and Technological Sciences. Rimar Academy, 2025. https://doi.org/10.47832/minarcongress13-8.

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The experiment was conducted in the Central Plant Tissue Culture Laboratory at the College of Agricultural Engineering Sciences, University of Baghdad, during the period 2021–2023. The study aimed to identify the optimal UV doses for enhancing callus induction and enzymatic activity, which serve as indicators of the plant's tolerance to abiotic stress. Callus from two sunflower cultivars, Aqmar and Shamoos, was used to induce genetic variation through UV-C radiation (wavelength &lt; 280 nm) for exposure durations of 0, 10, 20, and 30 minutes. The lethal dose (LD50) was determined to be 20 minu
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M. AMIN, S., and F. K. IBRAHIM. "TOXIC KINETICS OF CIPROFLOXACIN IN MICE." In V. International Scientific Congress of Pure, Applied and Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress5-11.

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Ciprofloxacin belongs to a class of drugs called quinolone antibiotics. It is widely used in humans and animals. Excessive use of it increases the risk of poisoning, which occurs due to medical errors or due to the use of high doses to overcome antibiotic resistance. Due to the lack of research on its toxic kinetics. Therefore, the goal of our research was to measure its toxic kinetics in mice. First, the median lethal dose (LD50) was accounted for by the Dixon method. It was 1280,5 mg/kg body weight. Then mice were injected intraperitoneally at a dose of 800 mg/kg body weight. Blood samples w
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