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Journal articles on the topic 'Lead(n) derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Sanjay, Mathur, and Singh Anirudh. "Investigations on homo- and hetero-leptic isopropoxometallates of lead(II)." Journal of Indian Chemical Society Vol. 88, Nov 2011 (2011): 1673–78. https://doi.org/10.5281/zenodo.5791624.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>Manuscript received 19 July 2010, revised 11 April 2011, accepted 20 April 2011</em> Novel homo- and hetero-leptic isopropoxometallates of lead(ll) of the types [{{Zr<sub>2</sub>(OPr1)<sub>9</sub>}Pb(µ-F))}<sub>2</sub>] (la), [{{Nb(OPr<sup>i</sup>)<sub>6</sub>}Pb(µ-F)}<sub>2</sub>] (lb), [{{AI(OPr<sup>i</sup>)<sub>4</sub>}Pb(µ-F)}<sub>2</sub>] (lc), [{{Sn<sub>2</sub>(OPr<sup>i</sup>)<sub>9</sub>}Pb(µ-F)}<sub>2</sub>] (1d), [Pb{Zr<sub>2</sub>(OPr<sup>i</sup>)<sub>9</sub>}<sub>2</sub>]

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2

Khan, Momin, Ghulam Ahad, Ajmal Khan, et al. "Antiglycation Activity of N, N-Diethylthiobarbiturates Derivatives." Letters in Drug Design & Discovery 17, no. 4 (2020): 411–17. http://dx.doi.org/10.2174/1570180816666190516111516.

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Background: Previous identification of N,N-diethylthiobarbiturates as potential α-glucosidase inhibitory potential prompted us to investigate the antiglycation activity of these synthetic compounds (1-25) in order to identify the lead candidates for their possible antidiabetic potential. Methods: Synthetic compounds (1-25) were evaluated for their antiglycation activity using Bovine Serum Albumin assay (BSA). Results: Compounds exhibited varying degree of inhibition in the range of IC50 = 61.16 ± 2.3 - 656.71 ± 2.5 µM as compared to the standard rutin (IC50 = 294.5 ± 1.50 µM). Among the twenty

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3

Pyanylo, Yaroslav, and Galyna Pyanylo. "Analysis of approaches to mass-transfer modeling n non-stationary mode." Physico-mathematical modelling and informational technologies, no. 28, 29 (December 27, 2019): 55–64. http://dx.doi.org/10.15407/fmmit2020.28.055.

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A significant number of natural and physical processes are described by differential equations in partial derivatives or systems of differential equations in partial derivatives. Numerical methods have been found to find their solutions. Partial derivatives systems are solved mainly by reducing the order of the system of equations or reducing it to one differential equation. This procedure leads to an increase in the order of the differential equation. There are various restrictions and errors that can lead to additional solutions, boundary conditions for intermediate derivatives, and so on. T

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4

Balakina, Anastasia, Svyatoslav Gadomsky, Tatyana Kokovina, Tatyana Sashenkova, Denis Mishchenko, and Alexei Terentiev. "New Derivatives of N-Hydroxybutanamide: Preparation, MMP Inhibition, Cytotoxicity, and Antitumor Activity." International Journal of Molecular Sciences 24, no. 22 (2023): 16360. http://dx.doi.org/10.3390/ijms242216360.

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Using a novel method of N-substituted succinimide ring opening, new N-hydroxybutanamide derivatives were synthesized. These compounds were evaluated for their ability to inhibit matrix metalloproteinases (MMPs) and their cytotoxicity. The iodoaniline derivative of N1-hydroxy-N4-phenylbutanediamide showed the inhibition of MMP-2, MMP-9, and MMP-14 with an IC50 of 1–1.5 μM. All the compounds exhibited low toxicity towards carcinoma cell lines HeLa and HepG2. The iodoaniline derivative was also slightly toxic to glioma cell lines A-172 and U-251 MG. Non-cancerous FetMSC and Vero cells were found

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5

Heuger, Gerold, and Richard Göttlich. "Intermolecular addition reactions of N-alkyl-N-chlorosulfonamides to unsaturated compounds." Beilstein Journal of Organic Chemistry 11 (July 21, 2015): 1226–34. http://dx.doi.org/10.3762/bjoc.11.136.

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N-Alkyl-N-chlorosulfonamides add to alkenes under copper(I) catalysis. In reactions of styrene derivatives with terminal double bonds the addition products were obtained in excellent yield and high regioselectivity. Lower yields are obtained in addition reactions to non-aromatic alkenes. The reaction most likely proceeds via a redox catalysis and amidyl radicals, a concerted mechanism has been ruled out and a polar mechanism via chloronium ions would lead to the opposite regiochemistry.

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6

Wang, Jianing, Huinan Yu, Tianchen Fu, et al. "Wide band gap pyromellitic diimides for photo stable n-channel thin film transistors." Journal of Materials Chemistry C 8, no. 22 (2020): 7344–49. http://dx.doi.org/10.1039/d0tc00862a.

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7

Derkatch, Irina L., Michael E. Bradley, Ping Zhou, Yury O. Chernoff, and Susan W. Liebman. "Genetic and Environmental Factors Affecting the de novo Appearance of the [PSI + ] Prion in Saccharomyces cerevisiae." Genetics 147, no. 2 (1997): 507–19. http://dx.doi.org/10.1093/genetics/147.2.507.

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It has previously been shown that yeast prion [PSI + ] is cured by GuHCl, although reports on reversibility of curing were contradictory. Here we show that GuHCl treatment of both [PSI + ] and [psi – ] yeast strains results in two classes of [psi – ] derivatives: Pin+, in which [PSI + ] can be reinduced by Sup35p overproduction, and Pin–, in which overexpression of the complete SUP35 gene does not lead to the [PSI + ] appearance. However, in both Pin+ and Pin– derivatives [PSI + ] is reinduced by overproduction of a short Sup35p N-terminal fragment, thus, in principle, [PSI + ] curing remains

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8

Zabula, Alexander V., Andrey Yu Rogachev, and Robert West. "Self-Assembly of N-Heterocyclic Derivatives of Divalent Germanium, Tin, and Lead." Chemistry - A European Journal 20, no. 50 (2014): 16652–56. http://dx.doi.org/10.1002/chem.201405062.

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9

Hassenrück, Jessica, and Valentin Wittmann. "Cyclopropene derivatives of aminosugars for metabolic glycoengineering." Beilstein Journal of Organic Chemistry 15 (March 4, 2019): 584–601. http://dx.doi.org/10.3762/bjoc.15.54.

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Cyclopropenes have been proven valuable chemical reporter groups for metabolic glycoengineering (MGE). They readily react with tetrazines in an inverse electron-demand Diels–Alder (DAinv) reaction, a prime example of a bioorthogonal ligation reaction, allowing their visualization in biological systems. Here, we present a comparative study of six cyclopropene-modified hexosamine derivatives and their suitability for MGE. Three mannosamine derivatives in which the cyclopropene moiety is attached to the sugar by either an amide or a carbamate linkage and that differ by the presence or absence of

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10

Bautista-Aguilera, Óscar M., José M. Alonso, Marco Catto, et al. "N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases." Molecules 27, no. 21 (2022): 7437. http://dx.doi.org/10.3390/molecules27217437.

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Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical features of the disease at the biomolecular level. Given the limited therapeutic success of approved drugs, it is imperative to explore rationally supported therapeutic approaches to combat this disease. The search for novel scaffolds that bind to different receptors and inhibit AD disease-related enzymes could lead to new therapeutic solutions.

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11

Raev, Lyubomir Dimitrov, Ivo Christov Ivanov, Henri Angel Astroug, Wolfgang Frey, and Silviya Georgieva Agontseva. "Synthesis of some 6-alkylureido-4-aryl-2(1H)-pyridones: further transformations and pharmacological activity." Zeitschrift für Naturforschung B 70, no. 11 (2015): 797–807. http://dx.doi.org/10.1515/znb-2015-0066.

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AbstractThe Michael addition of enaminoesters to coumarins (1) does not lead to the formation of simple adducts 3 but to the rearranged 4-aryl-2-pyridone 4a. Now, N-carbamoylation of the 6-amino-2-pyridone 4a with alkyl isocyanates and further transformation of the corresponding novel ureido-2-pyridone derivatives 6a–g into chromeno[3,4-c]pyridines 5d,g and O-acetyl derivatives 7a–g are reported. All newly synthesized compounds were characterized by means of 1H/13C NMR, MS, IR spectra and elemental analysis. The structure of the ureide 6f and of the N-cyclohexyl-O-acetyl derivative 7g were add

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12

Aretz, Jonas, Paul Robin Wratil, Eike-Christian Wamhoff, Hoang Giang Nguyen, Werner Reutter, and Christoph Rademacher. "Fragment screening of N-acetylmannosamine kinase reveals noncarbohydrate inhibitors." Canadian Journal of Chemistry 94, no. 11 (2016): 920–26. http://dx.doi.org/10.1139/cjc-2015-0603.

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Many biological processes from infection to tumor immune evasion are controlled by cell surface sialylation. To gather further insight into these processes, methods to alter cell surface sialylation are required. One way to achieve this is inhibiting the key enzyme of sialic acid de novo biosynthesis, the intracellular bifunctional UDP-N-acetylglucosamine epimerase/N-acetylmannosamine kinase (GNE/MNK). Here, we present low molecular weight inhibitors of MNK activity based on picolinic acid derivatives. They were identified in a fragment screening using 19F NMR and validated in a biochemical in

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13

Wrackmeyer, Bernd, Heidi E. Maisel, and Max Herberhold. "N-Ferrocenyl Amines Bearing Boryl and Silyl Substituents at the Nitrogen Atom, Studied by 57Fe NMR Spectroscopy." Zeitschrift für Naturforschung B 56, no. 12 (2001): 1373–75. http://dx.doi.org/10.1515/znb-2001-1221.

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Abstract A series of ferrocene sandwich compounds such as N-ferrocenyl amine, Fc-NH2 (1), the Nsilylated derivatives Fc-NH -SiMe3 (2), Fc- NH -SiMe2H (3), (Fc-NH )2SiMe2 (4), the N-silyl- N-boryl derivatives Fc-N(SiMe3)(9-BBN) (5) (9-BBN = 9-borabicyclo[3.3.1]nonyl) and Fc- N(SiMe3)BEt2 (6), and the N-borylated derivatives Fc-NH -(9-BBN) (7) and Fc-NH -BEt2 (8) were studied by 57Fe NMR spectroscopy. The δ57Fe data reveal that CFcN(pp)π interactions lead to 57Fe nuclear magnetic deshielding (with respect to ferrocene) which is attenuated if competing BN(pp)π bonding becomes efficient (7, 8).

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14

Onisko, Mikhailo. "ARYLTELLUROCHLORINATION OF 5-ARYL(HETERYL)SUBSTITUTED N-ALLYL-1,2,4-TRIAZOLE-3-THIONE DERIVATIVES." Ukrainian Chemistry Journal 89, no. 8 (2023): 109–16. http://dx.doi.org/10.33609/2708-129x.89.08.2023.109-116.

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Condensed heterocycles based on 1,2,4-triazole have a wide range of biological activity. The introduction of a pharmacophore fragment of an aryl tertiary residue into their composition can significantly increase the bioactivity of the obtained compounds. Therefore, the synthesis of condensed derivatives of symmetrical 1,2,4-triazole with aryltellurium fragment is an urgent task. One of the most convenient and effective methods for introducing an aryltellurium fragment into such systems is the method of electrophilic intramolecular cyclisation of alkenyl derivatives of azaheterocycles. The aim

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15

Ayllón, José A., Oriol Vallcorba, and Concepción Domingo. "Solvent Influence in the Synthesis of Lead(II) Complexes Containing Benzoate Derivatives." Inorganics 12, no. 1 (2024): 24. http://dx.doi.org/10.3390/inorganics12010024.

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A series of lead(II) complexes incorporating benzoate derivative ligands was prepared: [Pb(2MeOBz)2]n (1), [Pb(2MeOBz)2(H2O)]n (2), [Pb2(1,4Bzdiox)4(DMSO)]n (3), [Pb(1,4Bzdiox)2(H2O)]n (4), [Pb(Pip)2(H2O)]n (5), and [Pb(Ac)(Pip)2(MeOH)]n (6) (2MeOBz: 2-methoxybenzoate; 1,4Bzdiox: 1,4-benzodioxan-5-carboxylate; DMSO: dimethylsulfoxide; Ac: acetate; Pip: piperonylate; MeOH: methanol). All compounds were characterized via elemental analysis, ATR-FTIR spectroscopy, and powder XRD. In addition, the crystal structures of some compounds were elucidated. Compounds 1 and 2, involving 2-methoxybenzoate,

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16

Gong, Tang, Liu та Liu. "Synthesis and Evaluation of Novel 2H-Benzo[e]-[1,2,4]thiadiazine 1,1-Dioxide Derivatives as PI3Kδ Inhibitors". Molecules 24, № 23 (2019): 4299. http://dx.doi.org/10.3390/molecules24234299.

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In previous work, we applied the rotation-limiting strategy and introduced a substituent at the 3-position of the pyrazolo [3,4-d]pyrimidin-4-amine as the affinity element to interact with the deeper hydrophobic pocket, discovered a series of novel quinazolinones as potent PI3Kδ inhibitors. Among them, the indole derivative 3 is one of the most selective PI3Kδ inhibitors and the 3,4-dimethoxyphenyl derivative 4 is a potent and selective dual PI3Kδ/γ inhibitor. In this study, we replaced the carbonyl group in the quinazolinone core with a sulfonyl group, designed a series of novel 2H-benzo[e][1

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17

Drandarov, Konstantin, Ioannis Tiritiris, and Willi Kantlehner. "Orthoamides and iminium salts, LXXXIX. Reactions of N,N,N′,N′,N″,N″,N′″,N′″-octamethyl-acetylene-bis(carboxamidinium) tetrafluoroborate with nucleophilic reagents – new methods for the preparation of amidinium salts and ketene aminalsa." Zeitschrift für Naturforschung B 70, no. 4 (2015): 225–41. http://dx.doi.org/10.1515/znb-2014-0204.

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AbstractThe acetylene-bis(carboxamidinium) salt 4 dehydrates carboxylic acids to the corresponding anhydrides, as the byproduct 2-oxo-but-2-en-amidinium salt 6b was isolated. Aromatic hydroxy compounds and 2-furyl-methylmercaptan add to the triple bond of the salt 4 to give 2-aryloxy- and 2-alkylmercapto-but-2-ene-bis(amidinium) salts 7–9. According to this reaction principle, 2-organoamino-buten-2-ene-bis(amidinium) salts 10 and 11 were prepared from 4 and primary and secondary amines, whereas 4-chlorobenzhydrazide reacted with 4 to give the imidazole-3-carboxamidinium salt 13. The reaction o

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18

Benedetti, Michele, Federica De Castro, Vincenza Lamacchia, Concetta Pacifico, Giovanni Natile, and Francesco P. Fanizzi. "Insertion of terminal alkyne into Pt–N bond of the square planar [PtI2(Me2phen)] complex." Dalton Transactions 46, no. 45 (2017): 15819–26. http://dx.doi.org/10.1039/c7dt03644b.

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The reactivity of [PtX<sub>2</sub>(Me<sub>2</sub>phen)] complexes (X = Cl, Br, I; Me<sub>2</sub>phen = 2,9-dimethyl-1,10-phenanthroline) with terminal alkynes is reported. Bromo and iodo derivatives lead to the formation of Pt(ii) alkenyl derivatives of the type [PtX<sub>2</sub>{κ<sup>2</sup>-N,C-(Z)-N̲1–N10–C̲C(H)(R)}] (N1–N10 = Me<sub>2</sub>phen) containing a Pt–N–C–C–N–C six membered metallacycle.

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19

Kumar, Arvind, Sushil Kumar, and Arun K. Mishra. "Docking of Some Bioactive 2-Chloro-N, N-Diphenylacetamide Derivatives on Cyclo-Oxygenase Enzyme and In-Vivo Analgesic Activity Evaluation." Oriental Journal of Chemistry 35, no. 6 (2019): 1627–33. http://dx.doi.org/10.13005/ojc/350602.

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The present work was aimed to synthesize some novel 2-chloro-N,N-diphenylacetamide derivatives conjugated with various benzaldehydes in multistep synthesis and further to undergo the process of docking on COX-1 and COX-2 enzymes. All the targeted synthesized compounds were subjected to evaluation of analgesic activity using hot plate model. Sophisticate analytical techniques via infrared spectroscopy, NMR, Mass spectroscopy and elemental analysis were employed to characterize the newly synthesized compounds. All the synthesized derivatives were evaluated for their analgesic activity. The synth

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20

Hajare, Rahul. "Profile of Similarity of Electron Withdrawing Structure Towards Analgesic-Anti-Inflammatory Activity of The Novel Isatin Analogue: Design and Implementation of Phase I Drug Discovery." International Physiology Journal, no. 2 (May 3, 2018): 7–14. http://dx.doi.org/10.14302/issn.2578-8590.ipj-18-2113.

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Isatin (1H-indole-2,3-dione ) and derivatives demonstrate a diverse array of biological activities. Isatin and 5-halo derivatives has reacted to form the schiff’s bases , mannich bases and friedal craft alkylation’s to form C-C, C-N, C=N bonds. From the spectral studies, isatin has undergoes reaction at C-3 and N-1 position and synthesized lead in present schme and seen the similarity of structure and analgesic-anti-inflammatory activity.

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21

Holý, Antonín. "Syntheses of Enantiomeric N-(3-Hydroxy-2-phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases." Collection of Czechoslovak Chemical Communications 58, no. 3 (1993): 649–74. http://dx.doi.org/10.1135/cccc19930649.

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Methods of preparation of N-(3-hydroxy-2-phosphonomethoxypropyl) (HPMP) derivatives of (2S)- and (2R)-configuration (compounds I and XXVII, respectively) are described. The general method starts from the corresponding N-(2,3-dihydroxypropyl) derivatives which were converted either into the (R)-enantiomers XIII by reaction of the base with (R)-glycidol butyrate (XII) in the presence of cesium carbonate and subsequent methanolysis, or into the (S)-enantiomers XI by alkylation of the base with (R)-2,2-dimethyl-4-tosyloxymethyl-1,3-dioxolane (V) in the presence of the same reagent. The amino group

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22

Yang, Shuai, Hongxiang Peng, Jiahong Tang, et al. "Discovery of Novel N-Pyridylpyrazole Thiazole Derivatives as Insecticide Leads." Agronomy 12, no. 10 (2022): 2472. http://dx.doi.org/10.3390/agronomy12102472.

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To develop effective insecticides against Lepidoptera pests, 25 novel N-pyridylpyrazole derivatives containing thiazole moiety were designed and synthesized based on the intermediate derivatization method (IDM). The insecticidal activities of these target compounds against Plutella xylostella (P. xylostella), Spodoptera exigua (S. exigua), and Spodoptera frugiperda (S. frugiperda) were evaluated. Bioassays indicated that compound 7g−7j exhibited good insecticidal activities. Compound 7g showed especially excellent insecticidal activities against P. xylostella, S. exigua, and S. frugiperda with

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23

Hemmerling, Hans-Jörg, Margarete Janoschka, and Hartmut Wunderlich. "Amidinadditionsprodukte des 1,2,3-Indantrionhydrats: Synthese und Strukturzuordnung durch Kristallstrukturanalyse, spektrale Daten und Blei(IV)acetatoxidation / Products of Amidinaddition to 1,2,3-Triketohydrindenhydrat: Synthesis and Determination by Crystal Structure, Spectral Data and Oxidation with Lead(IV)acetate." Zeitschrift für Naturforschung B 48, no. 8 (1993): 1094–104. http://dx.doi.org/10.1515/znb-1993-0811.

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The addition of amidines to 1,2,3-triketohydrindenhydrat gives cyclic dihydroxyindenoimidazoles. From N-substituted amidines mixtures of regioisomeric derivatives were obtained. Analysis of crystals revealed the major product of 2k to be 4k. They belong to the monoclinic space group P21/c (a = 889.1(2); b = 1186.6(3); c = 2783.5(7) pm; β = 91.26(2)°) with Ζ = 8 molecules including four molecules of ethanole per unit cell. These results were confirmed by oxidation with lead(IV)acetate, which lead to derivatives of isoindols.

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24

Rudell, David, James Mattheis, and John Fellman. "Diphenylamine and Diphenylamine Derivative Content of `Granny Smith' Peel: Influence of Ethylene Action and Regular or Controlled Atmosphere Storage Duration." HortScience 40, no. 4 (2005): 1144B—1144. http://dx.doi.org/10.21273/hortsci.40.4.1144b.

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Diphenylamine (DPA) is used for superficial scald control in apple fruit. A number of DPA derivatives resulting from C-nitration, C-hydroxylation, O-methylation, and N-nitrosation can be present in DPA-treated apple fruit after storage. The presence of the compounds may be indicative of metabolic processes that lead to scald development. Therefore, apple peel DPA and DPA derivative content in fruit treated at harvest with DPA or DPA plus 1-methylcyclopropene (1-MCP) was assayed upon removal of fruit from controlled atmosphere (CA) and regular atmosphere (RA) storage and during a 14-d post-stor

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25

Pal, Kumar Bhaskar, Mukul Mahanti, Xiaoli Huang, et al. "Quinoline–galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain." Organic & Biomolecular Chemistry 16, no. 34 (2018): 6295–305. http://dx.doi.org/10.1039/c8ob01354c.

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Straightforward methods to incorporate quinoline, indolizine, and coumarin structures into galactoside derivatives and evaluation of binding affinities towards a panel of human galectins lead to the discovery of selective and potent inhibitors of the N-terminal domain of galectin-8.

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26

Sánchez, Práxedes, Martín Hernández-Juárez, Nuria Rendón, et al. "Hydrogenation/dehydrogenation of N-heterocycles catalyzed by ruthenium complexes based on multimodal proton-responsive CNN(H) pincer ligands." Dalton Transactions 49, no. 28 (2020): 9583–87. http://dx.doi.org/10.1039/d0dt02326d.

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Ru-CNN(H) complexes are efficient precatalysts in the hydrogenation and dehydrogenation of N-heterocycles. Under basic conditions, these derivatives lead to the formation of Ru(0) species that are observed under catalytic conditions.

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27

Eujen, R., and A. Patorra. "Trifluoromethyl derivatives of lead — preparation and NMR spectra of (CF3)nPbR4−n (R = Me, Et; n = 1−3)." Journal of Fluorine Chemistry 54, no. 1-3 (1991): 366. http://dx.doi.org/10.1016/s0022-1139(00)83875-0.

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28

Kumar, Arvind, and Arun K. Mishra. "Synthesis, Toxicity Profile and Pharmacological Evaluation of Some New N,N-Diphenyl Amine Derivatives with Special Reference to Analgesic and Anti-inflammatory Activity." Letters in Organic Chemistry 17, no. 7 (2020): 560–70. http://dx.doi.org/10.2174/1570178617666191220150024.

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The present work was aimed to synthesize eight new diphenylamine derivatives by the reactions of 2-chloro-N-(4-(diphenyl amino) thiazol-2-yl)acetamide with substituted phenols in the chloroform along with anhydrous potassium carbonate and potassium iodide. The structures of newly synthesized compounds were characterized by IR, NMR, Mass and elemental analysis techniques. Toxicity profile (acute and subacute oral toxicity) and biological activity (analgesic and anti-inflammatory activity) of the synthesized derivatives was performed. Findings of the present work suggested that the synthesized c

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29

Ma, Juan, and Guo-Hua Gong. "Discovery of Novel 3,4-Dihydro-2(1H)-Quinolinone Sulfonamide Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity." Molecules 27, no. 5 (2022): 1537. http://dx.doi.org/10.3390/molecules27051537.

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In this paper, a small series of novel quinoline sulfonamide derivatives was synthesized, and their structure of the target compounds were confirmed by 1H NMR and MS. The screening of the news target compounds’ in vitro cytotoxic activities against tumor cell lines by the MTT method was performed. Among them, compound D13 (N-(4-methoxybenzyl)-2-oxo-N-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinoline-6-sulfonamide exhibited the strongest inhibitory effect on the proliferation of HeLa (IC50: 1.34 μM), and this value correlated well with the inhibitory activities of the compound against tubuli

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30

Mikhina, Ekaterina A., Daria V. Stepanycheva, Varvara P. Maksimova, et al. "Synthesis of Alkyl/Aryloxymethyl Derivatives of 1,2,4-Triazole-3-Carboxamides and Their Biological Activities." Molecules 29, no. 20 (2024): 4808. http://dx.doi.org/10.3390/molecules29204808.

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Ribavirin and its analogues exhibit an in vitro antiproliferative effect in cancer cells. In this work, we studied the biological activities of a number of alkyl/aryloxymethyl derivatives of ribavirin’s aglycon—1,2,4-triazole-3-carboxamide. Alkyl/arylxymethyl derivatives of 1,2,4-triazole-3-carboxamide with substitutions at the fifth or first position of the triazole ring, were synthesized and their antiproliferative and antimicrobial effects were assessed. For both series, the presence of an antiproliferative effect was investigated, and 1-alkyl/aryloxymethyl derivatives were shown an antimic

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31

Yang, Zechao, Lukas Fromm, Tim Sander, et al. "On-Surface Assembly of Hydrogen- and Halogen-Bonded Supramolecular Graphyne-Like Networks." Angewandte Chemie International Edition 59, no. 24 (2020): 9549–55. https://doi.org/10.1002/anie.201916708.

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Demonstrated here is a supramolecular approach to fabricate highly ordered monolayered hydrogen- and halogen-bonded graphyne-like two-dimensional (2D) materials from triethynyltriazine derivatives on Au(111) and Ag(111). The 2D networks are stabilized by N⋅⋅⋅H−C(sp) bonds and N⋅⋅⋅Br−C(sp) bonds to the triazine core. The structural properties and the binding energies of the supramolecular graphynes have been investigated by scanning tunneling microscopy in combination with density-functional theory calculations. It is revealed that the N⋅⋅&sdo

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32

Akasaka, Kazuaki, Hiroshi Ohrui, Hiroshi Meguro, Tateo Suzuki, and Harufumi Miwa. "Fluorometric Determination of Total and Bound Sulfite in Wine by N-(9-Acridinyl)maleimide." Journal of AOAC INTERNATIONAL 76, no. 6 (1993): 1385–88. http://dx.doi.org/10.1093/jaoac/76.6.1385.

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Abstract N-(9-Acridinyl)maleimide (NAM) reacts with sulfite in wine and gives strong fluorescent derivatives that lead to highly sensitive fluorometry of both total and bound sulfite in wine. Values of free and bound sulfite in wine determined by the NAM method and the modified Rankine method agreed. Sulfite was determined in &lt;200 μL wine within 2 h.

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Sonam, Bhatia, Singh Shaminder, and Sivaiah Kandarapu. "In silico Docking, ADME and Toxicity studies of Aryl Glyoxamide Derivatives as Anti-Virulence Agents." Trends in Pharmaceuticals and Nanotechnology 1, no. 2 (2019): 1–12. https://doi.org/10.5281/zenodo.2648368.

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<em>The expression of phenotypic characteristics in bacterial species is regulated by the signalling mechanism called quorum sensing (QS). In current scenario, the quorum sensing inhibitors (QSIs) have established themselves as attractive leads which can be exploited to overcome antimicrobial resistance exhibited by various pathogenic bacteria. Aryl glyoxamide derivatives belong to one such class among several chemical classes which are known to inhibit the quorum sensing in P. aeruginosa (MH602) and E. coli (MT102). These derivatives are mostly designed using amino acid esters and found to ex

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Souza, Wanderson C., Lucas D. Dias, Jaqueline E. de Queiroz, et al. "Synthesis and In silico Studies of N-acylhydrazone Derivatives as hnRNP K Ligands with Potential Anti-cancer Activity." Current Bioactive Compounds 16, no. 4 (2020): 432–41. http://dx.doi.org/10.2174/1573407215666190131121059.

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Background: A green and efficient synthetic methodology for a wide family of Nacylhydrazones (yields: 42-76%) using microwave irradiation is described, as well as their full characterization. Their potential antineoplastic activity was evaluated in vitro via EMSA by testing protein- DNA interactions. Among the 11 compounds tested, N-acylhydrazone derivative 5 bearing a hydroxyl group, showed the highest affinity to bind and inhibit the hnRNP K KH3 domain. Docking simulations of compound 5 showed three possible modes of interaction between the KH3 domain of hnRNP K protein and compound predict.

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Lebel, Hélène, Olivier Leogane, Kim Huard, and Sylvain Lectard. "Catalytic activation of nitrogen derivatives with transition-metal complexes." Pure and Applied Chemistry 78, no. 2 (2006): 363–75. http://dx.doi.org/10.1351/pac200678020363.

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Studies regarding the transition-metal-catalyzed decomposition of nitrogen derivatives toward Curtius rearrangement and the formation of nitrenes which undergo C-H insertion and aziridination reactions are presented. These processes lead to the formation of C-N bond with a high level of selectivity and efficiency.

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Bareš, Josef, Philippe Richard, Philippe Meunier, et al. "Reactions of C,N-chelated Tin(II) and Lead(II) Compounds with Zirconocene Dichloride Derivatives." Organometallics 28, no. 10 (2009): 3105–8. http://dx.doi.org/10.1021/om801120a.

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Liu, Xiyao, Yuyao Sun, Lifang Liu, et al. "Green Synthesis and Antifungal Activities of Novel N-Aryl Carbamate Derivatives." Molecules 29, no. 15 (2024): 3479. http://dx.doi.org/10.3390/molecules29153479.

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Carbamate is a key structural motif in the development of fungicidal compounds, which is still promising and robust in the discovery of green pesticides. Herein, we report the synthesis and evaluation of the fungicidal activity of 35 carbamate derivatives, among which 19 compounds were synthesized in our previous report. These derivatives were synthesized from aromatic amides in a single step, which was a green oxidation process for Hofmann rearrangement using oxone, KCl and NaOH. Their chemical structures were characterized by 1H NMR, 13C NMR and high-resolution mass spectrometry. Their antif

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Sycheva, E. S., D. B. Markina, M. S. Mukanova, L. A. Boltayeva, and O. T. Seilkhanov. "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-(4-METHOXYPHENYL)ACETAMIDE AND N-PHENYLACETAMIDE DERIVATIVES." Chemical Journal of Kazakhstan, no. 1 (March 30, 2023): 15–23. http://dx.doi.org/10.51580/2023-1.2710-1185.02.

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Particular attention in the cultivation of industrial and agricultural crops is paid to the fight against pathogenic fungi, which not only lead to significant yield losses, but they are also dangerous to humans. The aim of this work is the synthesis of biologically active compounds in the series of aromatic dithiocarbamic acids based on N-(4-methoxyphenyl)acetamide and N-phenylacetamide and the study of their antifungal and antibacterial activities. Results and discussion. Biologically active aromatic sodium dithiocarbamates were synthesized by the reaction of amines (N-(4-methoxyphenyl)acetam

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Cao, Jiangying, Chunlong Zhao, Hang Dong, Qifu Xu, and Yingjie Zhang. "Development of pyrazoline-based derivatives as aminopeptidase N inhibitors to overcome cancer invasion and metastasis." RSC Advances 11, no. 35 (2021): 21426–32. http://dx.doi.org/10.1039/d1ra03629g.

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Hughes, Andrew B., та Brad E. Sleebs. "Synthesis of New β-Amino Acids via 5-Oxazolidinones and the Arndt - Eistert Procedure". Australian Journal of Chemistry 58, № 11 (2005): 778. http://dx.doi.org/10.1071/ch05199.

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N-Methyl β-amino acids are potentially useful amino acid derivatives for incorporation in lead peptide therapeutics. The syntheses of five such compounds are presented. Their synthesis via 6-oxazinanones was low yielding. Alternatively, reductive cleavage of a 5-oxazolidinone gave the N-methyl α-amino acid, which was then homologated via an Arndt–Eistert procedure in high yield to give the N-methyl β-amino acid.

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Zlatković, Đorđe, Vladimir Dobričić, Jelena Srbljanović, et al. "N-(9-Acridinyl) Amino Acid Derivatives: Synthesis and In Vitro Evaluation of Anti-Toxoplasma gondii Activity." Pharmaceutics 17, no. 3 (2025): 374. https://doi.org/10.3390/pharmaceutics17030374.

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Background/Objectives: Acridine, an aromatic heterocyclic compound, serves as a basis for the synthesis of potent bioactive derivatives, displaying a broad spectrum of biological activity, such as antibacterial, antitumor, and antiparasitic activity. With the ability to undergo various types of electrophilic substitutions, introducing different side chains could lead to compounds being active towards various and potentially multiple biotargets. Toxoplasma gondii, a ubiquitous protozoan parasite with worldwide distribution, poses a major health threat, particularly in immunocompromised patients

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Mosula, L. M., V. S. Mosula, and D. B. Korobko. "In silico prediction of the pharmacological potential of new 7-alkyl-8-hydrazine derivatives of 1,3-dimethylxanthine." Current issues in pharmacy and medicine: science and practice 17, no. 3 (2024): 244–52. http://dx.doi.org/10.14739/2409-2932.2024.3.308118.

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The development of new drug-like molecules based on 7-R-8-hydrazine derivatives of 1,3-dimethylxanthine is promising in view of the known pharmacological effect of theophylline and functional hydrazine derivatives. In silico methods make it possible to rationalize the synthesis and reduce the number of chemical compounds at the stage of virtual screening by eliminating potentially ineffective molecules. The aim of the work was to carry out а virtual design and predictive evaluation of pharmacological activity of new 7-alkyl-8-hydrazine derivatives of 1,3-dimethylxanthine by in silico methods.

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Knörzer, G., and W. Siebert. "Pentaalkyl-Derivate des 2 ,3 - Dihiydro-1,3-diborols/Pentaalkyl Derivatives of the 2,3-Dihydro-1,3-diborole." Zeitschrift für Naturforschung B 45, no. 1 (1990): 15–18. http://dx.doi.org/10.1515/znb-1990-0105.

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AbstractDouble hydroboration of acetylene, propyne-1 and t-butylacetylene with HBCl2 · OEt2/BCl3 leads to the 1,1-bis(dichloroboryl)alkanes 2d, e, f, in which halogen exchange is achieved by BI3 to give 3d, e, f. Redox reactions between butyne-2, hexyne-3 and 3 result in the formation of compounds 4, which are alkylated with AlMe3 and AlEt3 to give the pentaalkyl derivatives 1d, e, f. Reactions of 1 with [(C5H5)Co(C2H4)2] an [(C5H5)N iCO]2 lead to the complexes 5 and 6.

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G A Miana, G. A. Miana, M. Kanwal M Kanwal, S. Maqsood S Maqsood, et al. "In-silico, Antioxidant and Antiepileptic Effect of N(2,3-methylenedioxy-4benzoyloxy-phenthylamine)-3,4-dimethyl-1, propanoamide Derivatives." Journal of the chemical society of pakistan 44, no. 4 (2022): 374. http://dx.doi.org/10.52568/001073/jcsp/44.04.2022.

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Epilepsy is a severe neurological illness that affects millions of people the globally and is characterized by unpredicted and intermittent seizures.This research aimed to investigate the antiepileptic and antioxidant properties of papaverine derivatives using in-silico, in-vitro, and in-vivo methods.Epileptic seizure was induced in Swiss albino mice of either gender by administering PTZ (pentylenetetrazol). The antioxidant potential of test compounds was computed using previously published DPPH assay methods with minor modifications, while In-silico experiments were conducted using Auto-dock

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Beena, K. P. "IN SILICO STUDIES OF N-(PHENYL SUBSTITUTED) 2-([PHENYL SUBSTITUTED) METHYLIDENE] AMINO)-N,4- DIPHENYL-6H-1,3-OXAZIN-6-AMINE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS." International Research Journal Of Pharmacy 12, no. 8 (2021): 41–45. http://dx.doi.org/10.7897/2230-8407.1208155.

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Resistance to bacteria is a growing threat to human health worldwide. The rate of discovery of new antibacterial is far outshined by the rate at which resistance is spreading. Therefore, there remains a pressing need for the development of new antibacterial drugs. Recent alarm estimates that deaths due to antimicrobial resistance may increase from 700,000 million lives annually by 2050. Glucosamine-6-phosphate (GlcN-6-P) synthase represents an interesting protein target because it plays an essential role in the protection of cell wall. The primary aim and objective of this study is to identify

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Patel, Vijay K., and Harish Rajak. "Development of Structure Activity Correlation Model on Aroylindole Derivatives as Anticancer Agents." Letters in Drug Design & Discovery 15, no. 2 (2018): 143–53. http://dx.doi.org/10.2174/1570180814666170823161751.

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Background: Aroylindole derivatives, the structural analogs of Combretastatin A-4 has been found to possess potent growth inhibitory activity on several cancer cell lines due to its excellent antitumor and antivascular activities. The aim of present research work is to identify lead and establish structure activity correlation of trimethoxyaroylindole derivatives, using integrated ligand and structure based computational approaches. Materials and Methods: A correlation between structure and biological activity was established using computational approaches i.e., structure activity correlation

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Filimonov, Aleksandr S., Olga A. Luzina, and Nariman F. Salakhutdinov. "Synthesis of Novel Thiazoles Based on (+)-Usnic Acid." Molbank 2024, no. 4 (2024): M1894. http://dx.doi.org/10.3390/m1894.

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A series of usnic acid derivatives containing a thiazole ring with an amide substituent were synthesized. The convenient method for synthesis of these compounds is a reaction of 14-bromousnic acid with N-acylthioureas. Acylation of aminothiazole does not lead to the targeted compound.

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Dobrowolski, Michał A., Jędrzej Kaniewski, Tadeusz M. Krygowski та Michał K. Cyrański. "Acyclic versus cyclic π-electron delocalization. How is the substituent effect related to π-electron delocalization?" Collection of Czechoslovak Chemical Communications 74, № 1 (2009): 115–29. http://dx.doi.org/10.1135/cccc2008171.

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Substituent effect stabilization energies were estimated for sets of 27 para-substituted phenol derivatives, meta- and para-homodisubstituted benzene derivatives, trans-substituted ethenes, 4-substituted 1-hydroxy-1,3-cyclohexadienes and 1,4-homodisubstituted 1,3-cyclohexadienes based on the optimizations at the B3LYP/6-311+G** DFT level of theory. The following substituents were taken into account: C≡CH, C(CN)3, CF3, CH2NH2, CH3, CH=CH2, CHO, Cl, CN, COCH3, COCl, CONH2, COOCH3, COOH, F, NH2, NHCH3, N(CH3)2, NHOH, NO, NO2, OCH3, OH, Ph, H, SH, SO2CN. For hydroxyethenes and phenol derivatives t

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Abd El Aal, E. E., and S. Abd El Wanees. "Corrosion Control of Lead in Hydrochloric Acid Solutions by N-phenylcinnamimide and Some of Its Derivatives." CORROSION 67, no. 7 (2011): 075003–1. http://dx.doi.org/10.5006/1.3606455.

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Abd El Wanees, S., and E. E. Abd El Aal. "N-Phenylcinnamimide and some of its derivatives as inhibitors for corrosion of lead in HCl solutions." Corrosion Science 52, no. 2 (2010): 338–44. http://dx.doi.org/10.1016/j.corsci.2009.09.022.

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