Academic literature on the topic 'LeBell, Gene'

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Journal articles on the topic "LeBell, Gene"

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Spoerer, Mark, and Jochen Streb. "Leben, um zu arbeiten, oder arbeiten, um zu leben?" Geschichte und Gesellschaft 34, no. 1 (2008): 116–28. http://dx.doi.org/10.13109/gege.2008.34.1.116.

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Tavakoli, Mehdi, Amy M. Huang, Linda Cernichiaro-Espinosa, Carlos E. Mendoza Santiesteban, and Audina M. Berrocal. "Leber Congenital Amaurosis With Coats-Like Reaction and 3 Novel Sequence Variants: A Short Report." Journal of VitreoRetinal Diseases 4, no. 5 (2020): 430–32. http://dx.doi.org/10.1177/2474126420909248.

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Purpose: This report discusses a patient with Leber congenital amaurosis who presented with severe bilateral Coats-like reaction and 3 novel sequence variants in 2 different genes. Methods: The patient underwent complete ophthalmic and retinal evaluations including fluorescein angiography and optical coherence tomography as well as genetic studies. She was treated with intravitreal injection of intravitreal bevacizumab and laser photocoagulation. Results: Genetic analysis of the patient identified 2 novel sequence variants in the CEP290 (centrosomal protein 290) gene and another novel sequence variant in the RPGRIP1 (RPGR interacting protein 1) gene. Conclusions: The clinical presentation of Coats-like reaction in Leber congenital amaurosis can be associated with sequence variants in certain genes. The presence of multiple gene sequence variants in this patient may have contributed to the severity of disease.
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Jang, Yoon-ha, and Kwang-il Lim. "Recent Advances in Mitochondria-Targeted Gene Delivery." Molecules 23, no. 9 (2018): 2316. http://dx.doi.org/10.3390/molecules23092316.

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Mitochondria are the energy-producing organelles of cells. Mitochondrial dysfunctions link to various syndromes and diseases including myoclonic epilepsy and ragged-red fiber disease (MERRF), Leigh syndrome (LS), and Leber hereditary optic neuropathy (LHON). Primary mitochondrial diseases often result from mutations of mitochondrial genomes and nuclear genes that encode the mitochondrial components. However, complete intracellular correction of the mutated genetic parts relevant to mitochondrial structures and functions is technically challenging. Instead, there have been diverse attempts to provide corrected genetic materials with cells. In this review, we discuss recent novel physical, chemical and biological strategies, and methods to introduce genetic cargos into mitochondria of eukaryotic cells. Effective mitochondria-targeting gene delivery systems can reverse multiple mitochondrial disorders by enabling cells to produce functional mitochondrial components.
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Ziccardi, Cordeddu, Gaddini, et al. "Gene Therapy in Retinal Dystrophies." International Journal of Molecular Sciences 20, no. 22 (2019): 5722. http://dx.doi.org/10.3390/ijms20225722.

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Inherited retinal dystrophies (IRDs) are a group of clinically and genetically heterogeneous degenerative disorders. To date, mutations have been associated with IRDs in over 270 disease genes, but molecular diagnosis still remains elusive in about a third of cases. The methodologic developments in genome sequencing techniques that we have witnessed in this last decade have represented a turning point not only in diagnosis and prognosis but, above all, in the identification of new therapeutic perspectives. The discovery of new disease genes and pathogenetic mechanisms underlying IRDs has laid the groundwork for gene therapy approaches. Several clinical trials are ongoing, and the recent approval of Luxturna, the first gene therapy product for Leber congenital amaurosis, marks the beginning of a new era. Due to its anatomical and functional characteristics, the retina is the organ of choice for gene therapy, although there are quite a few difficulties in the translational approaches from preclinical models to humans. In the first part of this review, an overview of the current knowledge on methodological issues and future perspectives of gene therapy applied to IRDs is discussed; in the second part, the state of the art of clinical trials on the gene therapy approach in IRDs is illustrated.
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Golovkin, V. I., A. N. Shandurina, M. V. Fomintseva, E. M. Pervova, S. N. Zhulev, and Yu O. Garyshina. "CASE REPORT ABOUT LEBER HEREDITARY OPTIC NEUROPATHY:DIAGNOSTICS AND TREATMENT." HERALD of North-Western State Medical University named after I.I. Mechnikov 9, no. 1 (2017): 125–28. http://dx.doi.org/10.17816/mechnikov201791125-128.

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The article presents clinical case of rare form of Leber hereditary optic neuropathy with permanent hand tremor. diagnosis is confirmed by genetic test for major mutation. The possibility of treatment with transcutaneous electrostimulation of optic nerves in case of epigenetic provocation on a intoxicat- ing theory of gene expression is discussed.
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Wissinger, Bernd, Dorothea Besch, Britta Baumann, et al. "Mutation Analysis of the ND6 Gene in Patients with Lebers Hereditary Optic Neuropathy." Biochemical and Biophysical Research Communications 234, no. 2 (1997): 511–15. http://dx.doi.org/10.1006/bbrc.1997.6660.

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Omran, Heymut, GÜrsel Sasmaz, Karsten Häffner, et al. "Identification of a Gene Locus for Senior-Løken Syndrome in the Region of the Nephronophthisis Type 3 Gene." Journal of the American Society of Nephrology 13, no. 1 (2002): 75–79. http://dx.doi.org/10.1681/asn.v13175.

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ABSTRACT. Senior-Løken syndrome is an autosomal recessive disease with the main features of nephronophthisis (NPH) and Leber congenital amaurosis. The gene for adolescent nephronophthisis (NPHP3) was recently localized to chromosome 3q21-q22. The hypothesis was tested that Senior-Løken syndrome (SLS) might localize to the same region by studying a kindred of German ancestry with extended consanguinity and typical findings of SLS. Twenty highly polymorphic markers located in the vicinity of the NPHP3 genetic region were tested. Haplotype analysis revealed homozygosity by descent in affected individuals, and linkage analysis yielded a parametric maximum multipoint logarithm of likelihood of odds (LOD) score of 3.14, thus identifying the first locus for SLS. The SLS1 locus is flanked by D3S1587 and D3S621 and contains a 14-cM interval that contains the whole critical NPHP3 region. Three additional families with SLS were studied, and evidence for genetic heterogeneity in one of them was found. Localization of a SLS locus to the region of NPHP3 opens the possibilities of both diseases arising by mutations within the same pleiotropic gene or two adjacent genes.
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Hou, Alice Y., and Szilárd Kiss. "An Update on Ocular Gene Therapy for Monogenic and Multifactorial Retinal Diseases." Journal of VitreoRetinal Diseases 3, no. 5 (2019): 366–77. http://dx.doi.org/10.1177/2474126419876750.

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Monogenic and multifactorial retinal diseases are genetically and clinically diverse conditions that have historically shared an untreatable clinical course. In recent years, the advent of targeted treatments like gene therapy has enabled intraocular delivery of viral vectors, such as adeno-associated viruses and retroviruses, that establish long-term stable protein expression. Despite the innate distinctions between mainly monogenic disorders affecting the retina such as Leber congenital amaurosis (LCA), heterogeneous monogenic conditions like retinitis pigmentosa (RP), and multifactorial diseases such as age-related macular degeneration (AMD), gene therapy has shown great promise as a gene replacement or augmentation strategy to treat or halt these disorders. This review will present an overview of retinal gene therapy and provide a comprehensive analysis of past and current clinical trials for LCA, RP, and AMD. It will discuss the paradigm shift that has occurred in ophthalmic care thanks to the development of gene therapy, as well as its challenges for the future.
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Gadzicki, D., and M. Neises. "Psychosomatische Aspekte der Beratung bei erblichem Brustund Ovarialkarzinom." Onkologische Welt 01, no. 01 (2010): 26–31. http://dx.doi.org/10.1055/s-0038-1631625.

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ZusammenfassungDer Nachweis der Gene BRCA (breast cancer gene) 1 und 2 in den Jahren 1994 und 1995 war die Voraussetzung für die Diagnostik genetischer Grundlagen des familiären Mamma- und Ovarialkarzinoms. Eine Mutation in einem dieser Gene ist der wichtigste Risikofaktor für die Entstehung eines solchen Karzinoms. Etwa 5–10 % aller Mamma- und Ovarialkarzinome sind durch genetische Veranlagung bedingt. Die Möglichkeiten der prädiktiven Medizin können sowohl Entlastung, aber auch psychische Belastungen der Ratsuchenden nach sich ziehen. Die Kenntnis der eigenen Prognose oder die anderer innerhalb der Familie kann die Kommunikation und damit die Familienbeziehungen belasten. Die in der Regel noch gesunde Frau wird in der Beratung oft zum ersten Mal damit konfrontiert, dass die Erkrankung potenziell alle in der Familie und auch sie im Laufe ihres Lebens betreffen kann. Diese emotionale Belastung sollte in besonderer Weise berücksichtigt werden. Dabei ist innerhalb der Familie die Autonomie aller mit einem Recht auf Wissen, aber auch Nichtwissen sicherzustellen.
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Eickhoff, Hajo. "Auf Leben und Tod. Töten als Attraktion." Paragrana 20, no. 1 (2011): 51–63. http://dx.doi.org/10.1524/para.2011.0004.

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ZusammenfassungTöten wird unter der Perspektive der Attraktion betrachtet. Angreifer stellen eine kritische Nähe zu Lebewesen her, überschreiten deren Grenze und trennen von ihnen ab, was sie lebendig sein lässt. Dieses Töten als Trennen von Verbundenem eint die Seinsbereiche Physik, Chemie, Biologie und Kultur. Untersucht werden die verschiedenen Attraktionen, zu töten. Tiere töten, um sich zu ernähren, können aber artgleiche Tiere töten, wenn sie ein Areal oder eigene Gene sichern müssen. Menschen entwickeln kulturelle Attraktionen des Tötens wie Völkermord, Töten aus Hass, Rache oder Machtgewinn. Die Abwehr von Attraktionen des Tötens im Pazifismus und des Tötens von Tieren, sogar von Pflanzen, sind Anregungen für Wege in eine Globalgesellschaft.
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Dissertations / Theses on the topic "LeBell, Gene"

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Bandapalli, Obul Reddy. "Analysis of global gene expression profiles and invasion related genes of colorectal liver metastasis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15710.

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Die Leber ist das am häufigsten von Metastasen betroffene Organ und kann daher als Modellorgan für metastatische Invasion dienen. Aus diesem Grund war es das Ziel dieser Dissertation Genexpressionsprofile zu verstehen und metastasierungs- sowie invasionsassoziierte Gene zu identifizieren. Differentielle Genexpression wurde in drei Systemen überprüft: Einem syngenen Mausmodell, einem Xenograftmodell sowie in fünf Gewebeproben von Patienten. Genexpressionprofile des syngenen Mausmodells und der Patientenproben zeigten, dass man die Invasionsfront als Ganzes betrachten, um möglichst viele über-lappende Gene zu finden. Globale Genexpressionstudien, die auf den Wirtsteil der Invasionsfront zeigten bemerkenswerte Überrepräsentation z. B. der „GO-terms“ „extrazelluläre Matrix“, Zellkommunikation“, „Antwort auf biotischen Stimulus“, Strukturmolekülaktivität“ und „Zellwachstum“. Marker der Aktivierung hepatischer Sternzellen überrepräsentiert in der invasionsfront, was die Durchführbarkeit einer Analyse differentieller Genexpression im genomweiten Rahmen anzeigt. Globale Genexpressionsstudien, auf den Tumorzellen in der in vitro Situation, in vivo und in der Invasionsfront zeigten insgesamt einen Anstieg zellulärer Spezialisierung von der in vitro zur Invasionsfront. Sezernierte proangiogenetische Chemokine zeigten eine Hochregulation in der Invasionsfront. Das beta catenin Gen war in der Invasionsfront 9.6 fach erhöht im Vergleich zur in vitro Situation. Die Überprüfung der transkriptionellen Aktivierung von beta catenin über die Prüfung der Promotoraktivität zeigte einen 18.4 fachen Anstieg in den Tumorzellen der Invasionsfront. Weiterhin war die Promotoraktivität (an Hand der Aktivität der mRNA des Alkalischen Phosphatase Reportergens) im Tumorinneren 3.5 fach höher als in der Zellkultur, was für einen transkriptionellen Mechanismus der beta catenin Regulation zusätzlich zu den posttranslationalen Mechanismen spricht.<br>Liver is most frequently populated by metastases and may therefore serve as a model organ for metastatic invasion. So the aim of this thesis is to understand the gene expression profiles and identify metastasis and invasion related genes. Differential gene expression was examined in three systems: A syngeneic mouse model, a xenograft model and five clinical specimens. Gene expression profiles of a syngenic mouse model and human clinical specimen revealed that the invasion front should be considered as a whole to find more overlapping potential target genes. Global gene expression studies on the host part of the invasion front, revealed a pronounced overrepresentation of GO-terms (e.g. “extracellular matrix”, “cell communication”, “response to biotic stimulus”, “structural molecule activity” and “cell growth”). Hepatic stellate cell activation markers were over-represented in the invasion front demonstrating the feasibility of a differential gene expression approach on a genome wide scale. Global gene expression studies of the tumor cells in vitro, in vivo and tumor part of the invasion front revealed an overall increase of cellular specialization from in vitro to the invasion front. Secreted angiogenic cytokines were found to be up regulated in the invasion front. Beta catenin gene of “cell adhesion” GO term was elevated 9.6 fold in invasion front compared to in vitro. Evaluation of transcriptional up-regulation of beta catenin by promoter activity showed an 18.4 fold increase in the tumor cells of the invasion front as compared to those from the faraway tumor. Promoter activity assessed by soluble human placental alkaline phosphatase reporter gene mRNA was 3.5 fold higher in the inner parts of the tumor than in vitro cells indicating a transcriptional mechanism of beta catenin regulation in addition to the posttranslational regulatory mechanisms.
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Krüger, Julia [Verfasser], Michael [Akademischer Betreuer] Lebert, and Michael [Gutachter] Lebert. "Analysis of Gene Expression Changes Induced by Differential Acceleration and Swimming Behavior in Euglena gracilis / Julia Krüger ; Gutachter: Michael Lebert ; Betreuer: Michael Lebert." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2019. http://d-nb.info/1229194142/34.

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Reichart, Thomas. "DNA microarray based gene expression profiling in human hepatocyte cells to serve as a basis for dynamic modelling of the human liver a systems biology approach /." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-35867.

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Hildebrandt, Bert, I. Heide, Christian Thiede, et al. "Lack of Point Mutations in Exons 11–23 of the Retinoblastoma Susceptibility Gene RB-1 in Liver Metastases of Colorectal Carcinoma." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133565.

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Hildebrandt, Bert, I. Heide, Christian Thiede, et al. "Lack of Point Mutations in Exons 11–23 of the Retinoblastoma Susceptibility Gene RB-1 in Liver Metastases of Colorectal Carcinoma." Karger, 2000. https://tud.qucosa.de/id/qucosa%3A27516.

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Tremmel, Roman [Verfasser], and Ulrich M. [Akademischer Betreuer] Zanger. "Bioinformatische Analyse und funktionelle Charakterisierung von strukturellen Genvarianten in ADME-Genen in humaner Leber / Roman Tremmel. Betreuer: Ulrich M. Zanger." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2016. http://d-nb.info/1105554260/34.

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Tron, Kyrylo. "Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene in vivo and in vitro studies /." Doctoral thesis, [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/tron/tron.pdf.

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Quintas, Bruna Filipa Gomes Botelho. "Characterization of a portuguese LCA family secondary to homozygous RPE65 mutation." Master's thesis, 2014. http://hdl.handle.net/10316/37311.

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Cimica, Velasco. "Serial Analysis of Gene Expression of Rat Liver Regeneration by Oval Hepatic Stem Cells." Doctoral thesis, 2004. http://hdl.handle.net/11858/00-1735-0000-0006-AE70-6.

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Ramadori, Pierluigi. "UPSTREAM PATHWAYS REGULATING ERYTHROPOIETIN GENE EXPRESSION IN THE LIVER DURING ACUTE PHASE RESPONSE: A CENTRAL ROLE FOR IL-6." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-B68F-5.

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Books on the topic "LeBell, Gene"

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LeBell, Gene. The godfather of grappling: "Judo" Gene LeBell (aka: "the toughest man alive") : the only authorized autobiography. G. LeBell Enterprises, 2004.

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Collins, Francis S. Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6.

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LeBell, Gene. Gene LeBell's handbook of self-defense. Pro-Action Pub., 1996.

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Gene, LeBell, ed. Gene LeBell's grappling and self-defense for the young adult. Pro-Action Pub., 1996.

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Pernicka, Susanne. Wem gehören die Gene?: Patente auf Leben für ein neues Wachstumsregime. Argument Verlag, 2001.

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LeBell, Gene. Gene LeBell's handbook of judo: A step-by-step guide to winning in sport judo. Pro-Action Pub., 1996.

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Bronnen, Barbara. Friedhöfe: Warum ich für mein Leben gern auf Friedhöfe gehe. Deutscher Taschenbuch Verlag, 1997.

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Spangenberg, Joachim. Das grüne Gold der Gene: Vom Angriff der Gentechnik auf das Leben in der Dritten Welt. P. Hammer, 1992.

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Goethe, Johann Wolfgang von. Gede dui hua lu: Gespräche mit Goethe in den letzen jahren seines lebens / Johann Peter Eckermann. Shanghai yi wen chu ban she, 2008.

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Schuhmann, Klaus. "Ich gehe wie ich kam, arm und verachtet": Leben und Werk Max Hermann-Neisses (1886-1941). Aisthesis, 2003.

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Book chapters on the topic "LeBell, Gene"

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Tariverdian, Gholamali, and Werner Buselmaier. "Einige Fragen aus dem täglichen Leben." In Chromosomen, Gene, Mutationen. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-57775-8_15.

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Collins, Francis S. "Gene und Keime." In Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6_6.

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Collins, Francis S. "Gene und Gehirn." In Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6_7.

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Collins, Francis S. "Gene und Altern." In Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6_8.

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Krauß, Veiko. "Leben und Evolution sind zwei Seiten einer Medaille." In Gene, Zufall, Selektion. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41755-9_2.

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Collins, Francis S. "Das richtige Medikament in der richtigen Dosierung für den richtigen Patienten." In Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6_9.

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Collins, Francis S. "Die Zukunft hat schon stattgefunden." In Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6_1.

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Collins, Francis S. "Eine Zukunftsvision." In Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6_10.

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Collins, Francis S. "Wenn Gene Fehler machen, ist man persönlich betroffen." In Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6_2.

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Collins, Francis S. "Möchten Sie nun Ihre eigenen Geheimnisse kennenlernen?" In Meine Gene – mein Leben. Spektrum Akademischer Verlag, 2011. http://dx.doi.org/10.1007/978-3-8274-2778-6_3.

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Conference papers on the topic "LeBell, Gene"

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Longerich, T., V. Endris, O. Neumann, et al. "RSPO2 gene rearrangement – a new cancer driver in the liver." In 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0038-1677216.

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Gülow, K., E. Ostheim, and M. Müller-Schilling. "The Alpha-1-Fetoprotein (AFP) – A novel target gene for p63." In 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0040-1722066.

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Alonso-Peña, M., A. Geier, and H. Hermanns. "Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by Oncostatin M." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402187.

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Hall, RA, M. Krawczyk, M. Milkiewicz, et al. "Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene." In 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0038-1677075.

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Li, Y., T. Itze, C. Meyer, et al. "Low ECM1 expression temporally promote proliferative, tumorigenic and inflammatory gene signatures in mouse liver." In 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0040-1721974.

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Voitl, R., T. Hippchen, C. Zhang-Hagenlocher, KH Weiss, and C. Rupp. "The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis." In 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0038-1677155.

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Reuken, P., P. Lutz, M. Casper, et al. "The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis." In 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0038-1677228.

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Krawczyk, M., JM Schattenberg, L. Schubert, et al. "PNPLA3 and HSD17B13 gene variants exert opposite effects on fatty liver phenotypes: results from the FLAG cohort." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402166.

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Weiler, S., T. Lutz, M. Bissinger, et al. "The TAZ target gene ITGAV regulates invasion and positively feedbacks on YAP and TAZ in liver cancer cells." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402210.

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Alonso-Pena, M., A. Geier, and HM Hermanns. "Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by the interleukin-6-type cytokine Oncostatin M." In 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0038-1677058.

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