Academic literature on the topic 'Lee, J. Yimm'

MicroRNAs (miRNAs) are implicated in the differentiation and function of many cell types. We provide genetic and in vivo evidence that the two RNaseIII enzymes, Drosha and Dicer, do indeed function in the same pathway. These have previously been shown to mediate the stepwise maturation of miRNAs (Lee, Y., C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, J. Lee, P. Provost, O. Radmark, S. Kim, and V.N. Kim. 2003. Nature. 425:415–419), and genetic ablation of either within the T cell compartment, or specifically within Foxp3+ regulatory T (T reg) cells, results in identical phenotypes. We found that miRNA biogenesis is indispensable for the function of T reg cells. Specific deletion of either Drosha or Dicer phenocopies mice lacking a functional Foxp3 gene or Foxp3+ cells, whereas deletion throughout the T cell compartment also results in spontaneous inflammatory disease, but later in life. Thus, miRNA-dependent regulation is critical for preventing spontaneous inflammation and autoimmunity.

Background:Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases and is characterized by multisystemic affection. Hospitalization is a frequent eventuality in the course of the disease with a rate of 0.50 admissions/person-year estimated; infections and disease activity explain the highest percentage of admissions, risk factors depend on the population studied, among which are cardiopulmonary disease, elevated creatinine, thrombocytopenia, high disease activity and use of immunosuppression, however, the risk factors in the Mexican population are unknown.Objectives:To identify risk factors for hospitalization in patients with generalized lupus erythematosus, and as a secondary result, identify the main causes of hospitalization in our population.Methods:Observational, analytical, case-control and ambilective study of patients with a diagnosis of SLE at the Hospital Central Dr. Ignacio Morones Prieto in San Luis Potosí, Mexico, evaluated from January 2019 to October 2020; for each hospitalized patient with SLE, a non-hospitalized patient with SLE evaluated in the Rheumatology outpatient clinic was taken as a control, to establish a 1: 1 relationship. Continuous variables were expressed as mean or median; and standard deviation or interquartile ranges (IQR) according to the distribution. The categorical variables were expressed in proportion. The comparison of continuous variables was carried out with the unpaired Student’s t test or Mann Whitney’s U according to their distribution, while the categorical variables were compared with Fisher’s exact test or X 2 and logistic regression analysis was performed.Results:A total of 202 patients were collected, 179 were women (88.6%); of all patients, 89 (45.1%) were hospitalized, who were younger at diagnosis and time of evolution of the disease and greater SLEDAI and accumulated damage than non-hospitalized patients. The main causes of hospitalization were disease activity in 60.7% of cases, with kidney disease being the most important, followed by infectious in 22.5% and pharmacological toxicity in 5.6%. In the multivariate analysis, the risk factors associated with hospitalization identified were creatinine (p 0.018), CRP (p 0.046), neutrophils (p 0.013), constitutional condition (p 0.044), hematological (p 0.003) and renal (p. p 0.004), see Table 1. Factors associated with mortality were creatinine (p 0.022), INR (0.019), days of ICU stay (p 0.020) and the use of vasopressors (p 0.003). The use of antimalarials was a protective factor for hospitalization with p 0.0003. Survival analysis was performed where it was observed that patients with infection acquired in the hospital had a lower probability of survival with p 0.012.Conclusion:In our center, disease activity continues to be the most frequent cause of hospitalization and elevated creatinine is a risk factor for hospitalization and mortality in patients with SLE. In-hospital infections were a factor of poor survival.References:[1]Lee J, Park D, Kang J, Choi S, Yim Y, Kim J, et al. The rate of and risk factors for frequent hospitalization in systemic lupus erythematosus: results from the Korean lupus network registry. Lupus 2016. DOI: 10.1177/0961203316640916.[2]Li D, Madhoun H, Jarjour W. Determining risk factors that increase hospitalizations in patients with systemic lupus erythematosus. Lupus 2018. DOI. 10.1177/0961203318770534.Table 1.Multivariate analysis of factors associated with hospitalization in patients with SLEORCI 95%pAge of diagnosis1.040.993 - 1.110.097Previos prednisone dose1.171.030 – 1.410.069Use of antimalarials0.040.006 - 0.210.003Hemoglobin0.780.57 – 1.010.074Neutrophils1.581.13 – 2.390.013Creatinine2.961.40 – 8.860.018CRP1.160.99 – 1.360.046Constitutional condition9.191.24 – 105.220.044Hematological condition34.53.82 – 517.490.003Renal condition16.052.66 – 133.420.004Cardiopulmonary condition19.790.84 – 843.460.081Disclosure of Interests:None declared

Background:Partial repair of bone erosions in rheumatoid arthritis (RA) is known from high-resolution peripheral quantitative computer tomography (HR-pQCT) studies in patients with moderate to high disease activity using biologics [1]. Whether RANKL inhibition by denosumab is efficacious in healing existing erosions in RA patients with low disease activity or in remission on conventional synthetic DMARDs is uncertain.Objectives:To evaluate the effects of denosumab on erosion healing at 2-4 metacarpophalangeal head as determined by HR-pQCT in patients with RA with stable disease.Methods:This was a randomized, placebo-controlled, double-blind study. RA patients with disease activity score 28 joints (DAS28) ≤5.1 were randomized (1:1) to subcutaneous denosumab 60 mg or placebo once every six months for 24 months. The primary outcome was erosion healing at MCP 2-4 on HR-pQCT at 12 months. The effects of denosumab on erosion and joint space parameters on HR-pQCT and radiographs, disease activity and health assessment questionnaire-disability index (HAQ-DI) were also examined.Results:At 24 months, HR-pQCT images were analyzed in 98 patients. Baseline demographic, clinical characteristics and imaging parameters were comparable between the two treatment groups (table 1). Seventeen patients in each group (placebo group: 17/52, 32.6%; denosumab group: 17/50, 34.0%) achieved sustained low disease activity (DAS28 ≤ 3.2) throughout the 24 months. At 12 months, changes in erosion parameters on HR-pQCT were similar between the two groups. At 24 months, new erosions (19% vs 9%, p=0.009) and erosion progression (34% vs 16%, p<0.001) were more common in the placebo group than the denosumab group. Erosion healing was seen in a significantly higher proportion of patients in the denosumab group (20% vs 6%, p=0.045) at 24 months. The details of the changes in HR-pQCT erosion parameters are shown in figure 1. No significant differences in the changes in joint space parameters on HR-pQCT, van der Heijde-Sharp erosion score, DAS28 and HAQ-DI were observed between the two groups at 12 and 24 months.Table 1.Baseline clinical, demographic, disease activity parameters and medicationsPlacebo (n=55)Denosumab (n=55)Total (n=110)Age56.5 ± 7.157.2 ± 8.556.8 ± 7.8Gender (Female)47 (86)41 (75)88 (80)Disease duration (years)8.5 ± 6.87.3 ± 6.97.9 ± 6.8Rheumatoid factor positive40 (72)38 (69)78 (71)ACPA positive43 (78)44 (80)87 (79)DAS28-CRP2.43 ± 0.832.6 ± 0.922.51 ± 0.88DAS28-CRP>3.28 (15)13 (24)21 (19)HAQ-DI (0-3)0.31 ± 0.380.46 ± 0.470.39 ± 0.43csDMARDs49 (89)52 (95)101 (92)Combination csDMARDs26 (47)33 (60)59 (54)Glucocorticoids5 (10)5 (9)10 (9)vdH- Sharp erosion score10.4 ± 18.48.9 ± 13.89.6 ± 16.2vdH- Sharp JSN score12.4 ± 17.711.5 ± 17.211.9 ± 17.4Lumbar spine aBMD, g/cm20.914 ± 0.1470.930 ± 0.1430.922 ± 0.145Total hip aBMD, g/cm20.837 ± 0.1020.847 ± 0.1460.841 ± 0.125Femoral neck aBMD, g/cm20.681 ± 0.0990.695 ± 0.1280.687 ± 0.114Data are reported as mean ± SD or number (%). ACPA: Anti-cyclic citrullinated peptide antibody; DAS28: disease activity score 28; csDMARDs: conventional synthetic disease modifying anti-rheumatic drug. HAQ-DI: health assessment questionnaire disability index; vdH- Sharp score: Van der Heijde- Sharp score; aBMD: areal bone mineral densityConclusion:Although no differences in erosion parameters were observed at 12 months, denosumab was more efficacious than placebo in erosion repair on HR-pQCT after 24 months.References:[1]Finzel S, Rech J, Schmidt S, et al. Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study. Ann Rheum Dis 2013;72:396-400.Figure 1.Changes in erosion parameters by HR-pQCT. (A) Percentage of patients with overall erosion healing; (B) Outcome of individual erosion with healing, progression and new erosion detected across study period; change in (C) mean erosion volume; (D) total erosion volume; (E) erosion width; (F) erosion depth and (G) marginal osteosclerosis per patient.Disclosure of Interests:Ho SO: None declared, Isaac T. Cheng: None declared, Sze-Lok Lau: None declared, Evelyn Chow: None declared, Tommy Lam: None declared, Vivian W Hung: None declared, Edmund Li: None declared, James F Griffith: None declared, Vivian WY Lee: None declared, Lin Shi: None declared, Junbin Huang: None declared, Yan Kitty Kwok: None declared, Isaac C Yim: None declared, Tena K. Li: None declared, Vincent Lo: None declared, Jolly M Lee: None declared, Jack Jock Wai Lee: None declared, Ling Qin: None declared, Lai-Shan Tam Grant/research support from: Grants from Novartis and Pfizer

Background:While carotid ultrasound (US) has been advocated for cardiovascular (CV) risk screening in patients with rheumatoid arthritis as various traditional scores underestimate CV risk, whether subclinical carotid atherosclerosis (SCA) is associated with coronary atherosclerosis on coronary computed tomography angiography (CCTA) in patients with psoriatic arthritis (PsA) remains uncertain.Objectives:This study aimed to identify carotid US parameters which can discriminate PsA patients with coronary artery disease (CAD) and obstructive CAD (O-CAD), and determine the utility in combination with Framingham Risk Score (FRS).Methods:Ninety-one PsA patients (56 males; age: 50±11years, disease duration: 9.4±9.2years) without overt CV diseases were recruited. Carotid intima-media thickness (cIMT), presence of plaque and total plaque area (TPA) were determined by high-resolution US. CAD was defined as the presence of any coronary plaque on CCTA. O-CAD was defined as >50% stenosis of the lumen. FRS <10% indicates low CV risk, 10-19% indicates intermediate risk while ≥20% indicates high risk (1).Results:Thirty-five (38%) patient had carotid plaque. Fifty-five (60%) patients had CAD and 9 (10%) patients had O-CAD. 53 (58%), 25 (17%) and 13 (14%) were classified as low, moderate and high CV risk according to the FRS respectively. FRS underestimated the CV risk as only 11/55 (20%) of subjects with CAD were correctly identified as having high CV risk by FRS (Figure 1). Fifteen patients out of 53 (28%) with low CV risk based on FRS were reclassified as high CV risk by the presence of carotid plaque. Nine out of these 15 (60%) had CAD and 1/15 (6.7%) had O-CAD. Concerning the carotid ultrasound parameters, cIMT (mean and maximum) and TPA were increased in both the CAD+ and O-CAD+ group compared to those without CAD or O-CAD (Table 1). Multivariate logistic regression analysis revealed that mean cIMT (OR=1.06, 95% CI:1.01-1.11,p=0.013) was an independent explanatory variables associated with CAD. Meanwhile, mean cIMT (OR=1.06, 95%CI: 1.01-1.11,p=0.013) maximum cIMT (OR=1.06, 95%CI: 1.00-1.13,p=0.043), and TPA (OR=1.55, 95%CI: 1.01-2.36,p=0.043) were independent explanatory variables associated with O-CAD after adjusting for covariates. Based on Receiver Operating Curve (ROC) analysis, an optimal cut off for FRS at 5% and mean cIMT at 0.62mm yield 63% sensitivity and 73% specificity for the presence of CAD (AUC: 0.71,p=0.001).Table 1.Relationship between carotid ultrasound parameters and the presence and extent of coronary artery disease on coronary computed tomography angiography.Coronary artery diseaseNo (n=37)Yes (n=54)pMean carotid IMT, mm0.63±0.120.69±0.10.017Maximum carotid IMT, mm0.77±0.170.84±0.140.040Carotid Plaque, n, %Absence2646.4%3053.6%0.156Presence1131.4%2468.6%Total plaque area, mm20.0[0,6]0.0[0, 10.8]0.059Obstructive coronary artery diseaseNo (n=82)Yes (n=9)pMean carotid IMT, mm0.65±0.120.76±0.070.011Maximum carotid IMT, mm0.80±0.160.93±0.140.020Carotid Plaque, n, %Absence5393.0%47.0%0.235Presence2985.3%514.7%Total plaque area, mm20.0[0, 7.0]6.0[0, 15.3]0.103IMT-intima media thickness; coronary computed tomography angiography.Conclusion:Increased cIMT and TPA were associated with CAD and O-CAD in PsA patients while the presence of carotid plaque alone was insufficient to discriminate patient with or without CAD. A combination of US parameters should be considered for CV risk stratification in patients with PsA.References:[1]Ford ES et al.,J Am Coll Cardiol. 2004;43(10):1791-6.Disclosure of Interests:Isaac T. Cheng: None declared, Ka Tat Wong: None declared, Edmund Li: None declared, Priscilla C Wong: None declared, Billy Tin Lok Lai: None declared, Cheuk Wan Yim: None declared, Shirley King Yee Ying: None declared, Kitty Yan Kwok: None declared, Martin Li: None declared, Tena K. Li: None declared, Jack Jock Wai Lee: None declared, Alex Pui Wai Lee: None declared, Lai-Shan Tam Grant/research support from: Janssen, Pfizer, Novartis, Speakers bureau: Abbvie, Lilly, Sanofi

The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed.
 
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Zinc oxide (ZnO) has been widely deployed as electron conducting layer in emerging photovoltaics including quantum dot, perovskite and organic solar cells. Reducing the curing temperature of ZnO layer to below 200 oC is an essential requirement to reduce the cell fabrication cost enabled by large-scale processes such as ink-jet printing, spin coating or roll-roll printing. Herein, we present a novel water-based ZnO precursor stabilized with labile NH3, which allow us to spin coat crystalline ZnO thin films with temperatures below 200 oC. Thin film transistors (TFTs) and diode-type quantum dot solar cells (QD SCs) were fabricated using ZnO as electron conduction layer. In the QD SCs, a p-type 1,2-ethylenedithiol treated PbS QDs with a bandgap of 1.4 eV was spin-coated on top of ZnO layer by a layer-by-layer solid state ligand exchange process. Electron mobility of ZnO was about 0.1 cm2V-1s-1 as determined from TFT measurements. Power conversion efficiency of solar cells: FTO/ZnO/PbS/Au-Ag was 3.0% under AM1.5 irradiation conditions. The possibility of deposition of ZnO at low temperatures demonstrated herein is of important for solution processed electronic and optoelectronic devices. 
 Keywords
 ZnO, low-temperature, quantum dots, solar cells, TFTs
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Wearing clothing from the past is all the rage now. Different styles and aesthetics of vintage and historical clothing, original or appropriated, are popular with fashion wearers and home sewers. Social media is rich with images of anachronistic clothing and the major pattern companies have a large range of historical sewing patterns available. Butterick McCall, for example, have a Making History range of patterns for sewers of clothing from a range of historical periods up to the 1950s. The 1950s styled fashion is particularly popular with pattern producers. Yet little research exists that explains why anachronistic clothing is all the rage. Drawing on 28 interviews conducted by the author with women who wear/make 1950s styles clothing and a survey of 229 people who wear/make historical clothing, this article outlines four key reasons that help explain the popularity of wearing/making anachronistic clothing: It argues that there exists rage against four ‘fast fashion’ practices: environmental disregard, labour breaches, poor quality, and poor fit. Ethical consumption practices such as home sewing quality clothes that fit, seeks to ameliorate this rage. That much of what is being made is anachronistic speaks to past sewing techniques that were ethical and produced quality fitting garments rather than fashion today that doesn’t fit, is of poor quality, and it unethical in its production. Fig. 1: Craftivist Collective Rage: Protesting Fast FashionRage against Fast Fashion Rage against fast fashion is not new. Controversies over Disney and Nike’s use of child labour in the 1990s, the anti-fur campaigns of the 1980s, the widespread condemnation of factory conditions in Bangladesh in the wake of the 2016 Rana Plaza collapse and Tess Holiday’s Eff Your Beauty Standards campaign, are evidence of this. Fast fashion is “cheap, trendy clothing, that samples ideas from the catwalk or celebrity culture and turns them into garments … at breakneck speed” (Rauturier). It is produced cheaply in short turnarounds, manufactured offshore by slave labour, with the industry hiding these exploitative practices behind, and in, complex supply chains. The clothing is made from poor quality material, meaning it doesn’t last, and the material is not environmentally sustainable. Because of this fast fashion is generally not recycled and ends up as waste in landfills. This for Rauturier is what fast fashion is: “cheap, low quality materials, where clothes degrade after just a few wears and get thrown away”. The fast fashion industry engages in two discrete forms of obsolescence; planned and perceived. Planned obsolescence is where clothes are designed to have a short life-span, thus coercing the consumer into buying a replacement item sooner than intended. Claims that clothes now last only a few washes before falling apart are common in the media (Dunbar). This is due to conscious manufacturing techniques that reduce the lifespan of the clothes including using mixed fibres, poor-quality interfacing, and using polyester threads, to name a few. Perceived obsolescence is where the consumer believes an otherwise functioning item of clothing to no longer to be valued. This is borne out in the idea that an item is deemed to be “in vogue” or “in fashion” and its value to the consumer is thus embedded in that quality. Once it falls out of fashion is deemed worthless. Laver’s “fashion cycle” elucidated this idea over eighty years ago. Since the 1980s the fashion industry has sped up, moving from the traditional twice annual fashion seasons to the fast fashion system of constantly manufacturing new styles, sometimes weekly. The technologies that have allowed the rapid manufacturing of fast fashion mean that the clothes are cheaper and more readily available. The average price of clothing has dropped accordingly. An item that cost US$100 in 1993 only cost US$59.10 in 2013, a drop of 41 per cent (Perry, Chart). The average person in 2014 bought 60 per cent more clothing that they did in 2000. Fast fashion is generally unsaleable in the second-hand market, due to its volume and poor design and manufacture. Green notes that many charity clothing stores bin a large percentage of the fast fashion items they receive. Environmental Rage Consumers are increasingly expressing rage about the environmental impact of fast fashion. The production of different textiles places different stresses on the environment. Cotton, for example, accounts for one third of the fibres found in all textiles, yet it requires high levels of water. A single cotton shirt needs 2,700 litres of water alone, the equivalent to “what one person drinks in two-and-a-half years” (Drew & Yehounme). Synthetics don’t represent an environmentally friendly alternative. While they may need less water, they are more carbon-intensive and polyester has twice the carbon footprint of cotton (Drew & Yehounme). Criticisms of fast fashion also include “water pollution, the use of toxic chemicals and increasing levels of textile waste”. Textile dyeing is the “second largest polluter of clean water globally.” The inclusion of chemical in the manufacturing of textiles is “disruptive to hormones and carcinogenic” (Perry, Cost). Naomi Klein’s exposure of the past problems of fast fashion, and revelations such as these, inform why consumers are enraged by the fast fashion system. The State of Fashion 2019 Report found many of the issues Klein interrogated remain of concern to consumers. Consumers continue to feel enraged at the industry’s disregard for the environment (Shaw et al.) any many are seeking alternative sources of sustainable fashion. For some consumers, the ethical dilemmas are overcome by purchasing second-hand or recycled clothing, or participate in Clothing Exchanges. Another alternative to ameliorating the rage is to stop buying new clothes and to make and wear their own clothes. A recent article in The Guardian, “’Don’t Feed the Monster!’ The People Who Have Stopped Buying New Clothes” highlights the “growing movement” of people seeking to make a “personal change” in response to the ethical dilemmas fast fashion poses to the environment. While political groups like Fashion of Tomorrow argue for collective legislative changes to ensure environmental sustainability in the industry, consumers are also finding their own individual ways of ameliorating their rage against fast fashion. Over recent decades Australians have consistently shown concern over environmental issues. A 2016 national survey found that 63 per cent of Australians considered themselves to be environmentalists and this is echoed in the ABC’s War on Waste programme which examined attitudes to and effects of clothing waste in Australia. In my interviews with women wearing 1950s style clothing, almost 65 per cent indicated a distinct dissatisfaction with mainstream fashion and frustration particularly with pernicious ‘fast fashion’. One participant offered, “seeing the War on Waste and all the fast fashion … I really like if I can get it second hand … you know I feel like I am helping a little bit” [Gabrielle]. Traid, a network of UK charity clothes shops diverts 3 000 tonnes of clothes from landfill to the second-hand market annually, reported for 2017-18 a 30 per cent increase in its second-hand clothes sales (Coccoza). The Internet has helped expand the second-hand clothing market. Two participants offered these insights: “I am completely addicted to the Review Buy Swap and Sell Page” [Anna] and “Instagram is huge for girls like us to communicate and get ideas” [Ashleigh]. Slave Rage The history of fashion is replete with examples of exploitation of workers. From the seamstresses of France in the eighteenth century who had to turn to prostitution to supplement their meagre wages (Jones 16) to the twenty-first century sweatshop workers earning less than a living wage in developing nations, poor work conditions have plagued the industry. For Karl Marx fashion represented a contradiction within capitalism where labour was exploited to create a mass-produced item. He lambasted the fashion industry and its “murderous caprices”, and despite his dream that the invention of the sewing machine would alleviate the stress placed on garment workers, technology has only served to intensify its demands on its poor workers (Sullivan 36-37). The 2013 Rena Plaza factory disaster shows just how far some sections of the industry are willing to go in their race to the bottom.In the absence of enforceable, global fair-trade initiatives, it is hard for consumers to purchase goods that reflect their ethos (Shaw et al. 428). While there is much more focus on better labour practices in the fashion industry, as the Baptist World Aid Australia’s annual Ethical Fashion Report shows, consumers are still critical of the industry and its labour practices.A significant number of participants in my research indicated that they actively sought to purchase products that were produced free from worker exploitation. For some participants, the purchasing of second-hand clothing allowed them to circumnavigate the fast fashion system. For others, mid-century reproduction fashion was sourced from markets with strong labour laws and “ethically made” without the use of sweat shop labour” [Emma]. Alternatively, another participant rejected buying new vintage fashion and instead purchased originally made fashion, in this case clothing made 50 to 60 years ago. This was one was of ensuring “some poor … person has [not] had to work really hard for very little money … [while the] shop is gaining all the profits” [Melissa]. Quality Rage Planned obsolescence in fashion has existed at least since the 1940s when Dupont ensured their nylon stockings were thin enough to ladder to ensure repeat custom (Meynen). Since then manufacturers have deliberately used poor techniques and poor material – blended fabrics, unfinished seams, unfixed dyes, for example – to ensure that clothes fail quickly. A 2015 UK Barnardo’s survey found clothes were worn an average of just seven times, which is not surprising given that clothes can last as little as two washes before being worn out (Dunbar). Extreme planned obsolescence in concert with perceived obsolescence can lead to clothes being discarded before their short lifespan had expired. The War on Waste interviewed young women who wore clothes sometimes only once before discarding them.Not all women are concerned with keeping up to date with fashion, instead wanting to create their own identify though clothes and are therefore looking for durability in their clothes. Many of the women interviewed for this research were aware of the declining quality of clothes, often referring to those made before the fast fashion era as evidence of quality clothing. For many in this study, manufacturing of classically styled clothing was of higher concern than mimicking the latest fashion trend. Some indicated their “disgust” at the poor quality of fast fashion [Gabrielle]. Others has specific outrage at the cost of poorly made fast fashion: “I don’t like spending a lot of money on clothing that I know may not necessarily be well made” [Skye] and “I got sick of dresses just being see through … you know, seeing my bras under things” [Becky]. For another: “I don’t like the whole mass-produced thing. I don’t think that they are particularly well made … Sometimes they are made with a tiny waist but big boobs, there’s no seams on them, they’re just overlocked together …” [Vicky]. For other participants in this research fast fashion produced items were considered inferior to original items. One put it is this way: “[On using vintage wares] If something broke, you fixed it. You didn’t throw it away and go down to [the shop] and buy a new one ... You look at stuff from these days … you could buy a handbag today and you are like “is this going to be here in two years? Or is it going to fall apart in my hands?” … there’s that strength and durability that I do like” [Ashleigh]. For another, “vintage reproduction stuff is so well made, it’s not like fast fashion, like Vivien of Holloway and Pin Up Girl Clothing, their pieces last forever, they don’t fall apart after five washes like fast fashion” [Emma]. The following encapsulates the rage felt in response to fast fashion. I think a lot of people are wearing true vintage clothing more often as a kind of backlash to the whole fast fashion scene … you could walk into any shop and you could see a lot of clothing that is very, very cheap, but it’s also very cheaply made. You are going to wear it and it’s going to fall apart in six months and that is not something that I want to invest in. [Melissa]Fit RageFit is a multi-faceted issue that affects consumers in several ways: body size; body shape; and height. Body size refers to the actual physical size of the body, whether one is underweight, slim, average, muscular or fat. Fast fashion body size labelling reflects what the industry considers to be of ‘normal sizes’, ranging from a size 8 through to a size 16 (Hackett & Rall). Body shape is a separate, if not entirely discrete issue. Women differ widely in the ratios between their hips, bust and waist. Body shape distribution varies widely within populations, for example, the ‘Size USA’ study identified 11 different female body shapes with wide variations between populations (Lee et al.). Even this doesn’t consider bodies with physical disabilities. Clothing is designed to fit women of ‘average’ height, thus bodies that are taller or shorter are often excluded from fast fashion (Valtonen). Even though Australian sizing practices are based on erroneous historical data (Hackett and Rall; Kennedy), the fast fashion system continues to manufacture for average body shapes and average body heights, to the exclusion of others. Discrimination through clothing sizes represents one way in which social norms are reinforced. Garments for larger women are generally regarded as less fashionable (Peters 48). Enraged consumers label some of the offerings ‘fat sacks’, ‘tents’ and ‘camouflage wear’ (Colls 591-592). Further, plus size is often more expensive and having been ‘sized up’ from smaller sizes, the result is poor fit. Larger body’s therefore have less autonomy in fashioning their identity (Peters 45). Size restrictions can lead to consumers having to choose between going without a desired item or wearing a size too small for them as no larger alternative is available (Laitala et al. 33-34).The ideology behind the thin aesthetic is that it is framed as aspirational (Barry) and thus consumers are motivated to purchase clothes based upon a desire to fit in with this beauty ideal. This is a false dichotomy (Halliwell and Dittmar 105; Bian and Wang). For participants in this research rage at fashion fashions persistance in producing for ‘average’ sized women was clearly evident. For a plus-size participant: “I don’t suit modern stuff. I’m a bigger girl and that’s not what style is these days. And so, I find it just doesn’t work for me” [Ashleigh]. For non-plus participants, sizing rage was also evident: I’m just like a praying mantis, a long string bean. I’m slim, tall … I do have the body shape … that fast fashion catered for, and I can still dress in fast fashion, but I think the idea that so many women feel excluded by that kind of fashion, I just want to distance myself from it. So, so many women have struggles in the change rooms in shopping centres because things don’t fit them nicely. [Emma] For this participant reproduction fashion wasn’t vanity sized. That is, a dress from the 1950s had the body measurements on the label rather than a number reflecting an arbitrary and erroneous sizing system. Some noted their disregard for standardised sizing systems used exclusively for fast fashion: “I have very non-standard measurements … I don’t buy dresses for that reason … My bust and my waist and my hips don’t fit a standard. You know I can’t go “ooh that’s a 12, that’s an 18”. You know, I don’t believe in standard sizing basically” [Skye]. Variations of sizing by brands adds to the frustration of fashion consumers: “if someone says 'I’m a size 16' that means absolutely nothing. If you go between brands … [shop A] XXL to a [shop B] to a [shop C] XXL to a [shop D] XXL, you know … they’re not the same. They won’t fit the same, they don’t have the same fit” [Skye]. These women recognise that their body shape, size and/or height is not catered for by fast fashion. This frees them to look for alternatives beyond the product offerings of the mainstream fashion industry. Although the rage against aspects of fast fashion discussed here – environmental, labour, quality and fit – is not seeing people in the streets protesting, people are actively choosing to find alternatives to the problem of sourcing clothes that fit their ethos. ReferencesABC Television. "Coffee Cups and Fast Fashion." War on Waste. 30 May 2017. Barnardo's. 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