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1

Buggey, Jonathan, and Brian D. Hoit. "Left atrial strain." Current Opinion in Cardiology 33, no. 5 (September 2018): 479–85. http://dx.doi.org/10.1097/hco.0000000000000537.

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2

Litwin, Sheldon E. "Left Atrial Strain." JACC: Cardiovascular Imaging 13, no. 10 (October 2020): 2114–16. http://dx.doi.org/10.1016/j.jcmg.2020.07.037.

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3

Marwick, Thomas H., and Y. Chandrashekhar. "Left Atrial Strain." JACC: Cardiovascular Imaging 13, no. 10 (October 2020): 2278–79. http://dx.doi.org/10.1016/j.jcmg.2020.09.001.

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4

Cho, Goo-Yeong, and In-Chang Hwang. "Left Atrial Strain Measurement." JACC: Cardiovascular Imaging 13, no. 11 (November 2020): 2327–29. http://dx.doi.org/10.1016/j.jcmg.2020.05.014.

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5

Negishi, Kazuaki. "Incremental Diagnostic Value of Left Atrial Strain Over Left Atrial Volume." JACC: Cardiovascular Imaging 11, no. 10 (October 2018): 1416–18. http://dx.doi.org/10.1016/j.jcmg.2017.10.011.

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6

Tsujiuchi, Miki, Mio Ebato, Ryohei Fujimoto, Sakura Nagumo, Takuya Mizukami, Hideyuki Maezawa, and Hiroshi Suzuki. "Left Atrial Circumferential Strain is More Sensitive Index of Left Atrial Pressure Than Longitudinal Strain." Journal of Cardiac Failure 22, no. 9 (September 2016): S175. http://dx.doi.org/10.1016/j.cardfail.2016.07.123.

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7

Henein, Michael, Erik Tossavainen, Stefan Söderberg, Christer Grönlund, Manuel Gonzalez, and Per Lindqvist. "Left atrial strain rate estimates PCWP." International Cardiovascular Forum Journal 1, no. 1 (March 29, 2015): 25. http://dx.doi.org/10.17987/icfj.v1i1.11.

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<p><span>Objective: </span>Raised left atrial (LA) pressure is a common pathway for many pathologies and is known for its complications. It has a direct effect on LA cavity size and potentially also its function. We hypothesized that raised LA pressure, as shown by pulmonary capillary wedge pressure (PCWP), correlates with severity of global LA deformation abnormalities during atrial systole (LASRa).</p><p>Design and Patients: We prospectively studied 46 consecutive patients, mean age 61 +/-13 years, 17 males, of various etiologies who underwent right heart catheterization and simultaneous Doppler echocardiography using spectral, tissue Doppler and speckle tracking echocardiography techniques for assessing LA structure and function.</p><p><span>Results: </span>PCWP correlated with direct measurements of LA structure and function: LA volume (r= 0.43, p&lt;0.01) and LASRa (r=0.79, p&lt;0.001). PCWP correlated also with other indirect measures of LA pressure such as E/A (r=0.65, p&lt;0.001), E wave deceleration time (r=0.54, p&lt;0.001), E/e’ (r=0.49, p&lt;0.001) and LA systolic filling fraction (r=0.52, p&lt;0.001). However, LASRa together with LA systolic filling fraction, had the highest areas under the curve (0.83 and 0.87, respectively) for identifying patients with PCWP &gt; 15 mmHg.</p><p><span>Conclusion: </span>PCWP correlates with LA deformation rate during atrial systole and to a higher extent than conventional Doppler measures of raised LA pressures. These findings should have significant clinical implications in correctly identifying breathless patients due to raised LA pressure.</p><p> </p>
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8

To, Andrew C. Y., and Allan L. Klein. "Left Atrial Function: Doppler and Strain." Current Cardiovascular Imaging Reports 3, no. 5 (August 11, 2010): 276–85. http://dx.doi.org/10.1007/s12410-010-9041-9.

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9

Arslan, Sakir, Ziya Simsek, Fuat Gundogdu, Enbiya Aksakal, Mehmet Emin Kalkan, Yekta Gurlertop, Mustafa Kemal Erol, and Sule Karakelleoglu. "Can Left Atrial Strain and Strain Rate Imaging Be Used to Assess Left Atrial Appendage Function." Cardiology 121, no. 4 (2012): 255–60. http://dx.doi.org/10.1159/000337291.

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10

Russell, Ashley K., Gursukhmandeep Sidhu, Mary Jenkins, Wm Long, Mark Cassidy, and Nassir Marrouche. "PROGNOSTIC VALUE OF LEFT ATRIAL STRAIN AND RECURRENCE OF ATRIAL FIBRILLATION POST-ABLATION: A META ANALYSIS OF LEFT ATRIAL STRAIN AND LEFT ATRIAL VOLUME INDEX." Journal of the American College of Cardiology 77, no. 18 (May 2021): 1331. http://dx.doi.org/10.1016/s0735-1097(21)02689-9.

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11

N, Karthikrao. "ASSESSMENT OF LEFT ATRIAL FUNCTION IN PATIENTS WITHMITRAL VALVE DISEASES." Asian Journal of Pharmaceutical and Clinical Research 9, no. 6 (November 1, 2016): 334. http://dx.doi.org/10.22159/ajpcr.2016.v9i6.14677.

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ABSTRACTObjective:To observe and assess left atrial (LA) function by observing the differences in conventional Doppler echo parameters of left ventricular inflow, Left atrial appendage, among patients with mitral valve disease.Methods: Forty three mitral valve disease subjects appearing consecutively for echocardiogram (ECHO) test at the cardiology department in a tertiary care hospital were recruited into the study as per the pre-set inclusion and exclusion criteria. The data from the ECHO was pooled using Microsoft excel and analyzed using SPSS software by application of appropriate statistical tests.Results:Of the 43 objects, 39 had MS, 3 had MR and 2 of them were found to have both MS and MR. The major presenting symptom as observed in 33 subjects, was dyspnea. LA maximum volume was found to be 91±59 ml and minimum was 66±51 ml. Left atrial expansion index was 128±91. Left atrial active emptying fraction was 29±13 and passive emptying fraction was 31±15. No significant change in LA global strain among groups with MR and without MR was observed. Further, no significant difference was observed in left atrial indices like left atrial emptying fraction, left atrial passive emptying fraction, atrial fraction, Left atrial expansion index among groups having MR and no MR.Conclusion:LA contractile, reservoir and conduit function was significantly reduced in mitral valve diseases due to increased hemodynamic load. No significant difference was noted in global LA strain irrespective of MS or MR.Key Words: Valvular disease; Left atria; Strain; Contractile function
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12

Cameli, Matteo, Giulia Elena Mandoli, Ferdinando Loiacono, Stefania Sparla, Elisabetta Iardino, and Sergio Mondillo. "Left atrial strain: A useful index in atrial fibrillation." International Journal of Cardiology 220 (October 2016): 208–13. http://dx.doi.org/10.1016/j.ijcard.2016.06.197.

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13

Li, Shujuan, Junlin Yang, Ling Zhu, Yuese Lin, Xuandi Li, Yunquan Li, Zifang Huang, and Huishen Wang. "Ventricular and atrial mechanics and their interaction in patients with congenital scoliosis without clinical heart failure." Cardiology in the Young 25, no. 5 (September 12, 2014): 976–83. http://dx.doi.org/10.1017/s1047951114001504.

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AbstractObjectives: This study sought to evaluate left ventricular, right ventricular, and left atrial mechanics and their interactions in patients with congenital scoliosis without clinical heart failure.Methods: A total of 23 patients with a median age of 14 years and a median Cobb’s angle of 61° were studied. Ventricular and atrial myocardial deformation was measured using speckle tracking echocardiography. The results of the patients were compared with 22 controls.Results: Compared with controls, the patients had a significantly greater annular a velocity (p=0.04) and lower e/a ratio (p=0.03); the left ventricular deformation significantly decreased in radial global (p=0.04) and segmental systolic strain and early diastolic strain rate (p=0.03); the left atrial deformation showed a significantly lower positive strain (p=0.02), greater negative strain (p=0.01), and active contractile strain rate (p=0.01). For the patients, the Cobb’s angle was negatively correlated with the left ventricular global radial systolic strain (r=−0.65, p=0.001), left atrial positive strain (r=−0.68, p<0.001), and the left atrial negative strain was positively correlated with the left ventricular circumferential late diastolic strain rate (r=0.46, p=0.01). The left atrial conduit strain rate was positively correlated with the left ventricular circumferential early diastolic strain rate (r=0.42, p=0.03). The left atrial active contractile strain rate was positively correlated with the left ventricular longitudinal late diastolic strain rate (r=−0.4, p=0.03).Conclusions:Impaired left ventricular and altered left atrial mechanics occur relatively early in patients with congenital scoliosis, and are correlated with the severity of their scoliosis. Our findings provide evidence of preclinical heart dysfunction in patients with this disorder.
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14

Said Abdelkarim, Taher, Mohamed Abd El-Hafez Fouly, and Ashraf Zahrah. "Assessment of left atrial function in dilated cardiomyopathy patients using speckle-tracking echocardiography." Egyptian Cardiothoracic Surgeon 2, no. 1 (January 1, 2020): 27–32. http://dx.doi.org/10.35810/ects.v2i1.112.

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Background: The available methods to assess left atrial function (LAF) have some limitations as angle dependence and opposite distortion. The objective of the current study was to evaluate LAF in dilated cardiomyopathy (DCM) of ischemic (IDCM) and non-ischemic etiologies (NIDCM) using speckle tracking echocardiography (STE). Methods: 52 patients with systolic heart failure were included in our study; 27 with IDCM and 25 with NIDCM along with 15 healthy controls. All patients underwent conventional echocardiography, tissue doppler imaging, and speckle tracking echocardiography. The later modality was used to compare left atrial function in IDCM and NIDCM groups. Results: We found the left atrial maximum volume and the left atrial total emptying volume to be higher in patients with dilated cardiomyopathy compared to healthy patients (52.19 ± 6.01 vs. 21.87 ± 1.69 cm3/m2; p <0.001 and 28.67 ± 4.34 vs. 15.67 ± 2.02 cm3/m2, respectively). Conversely, left atrial emptying index and left atrial active ejection fraction were lower in patients with DCM compared to healthy controls (9.60 ± 2.29 vs. 8.27 ± 3.01 cm3/m2; p< 0.001 and 23 ± 2.56 vs. 37.47 ± 3.54 %; p<0.001, respectively). When comparing the IDCM group with NIDCM patients, we found no significant difference in left atrial maximum volume and left atrial active emptying volume. However, the NIDCM patients had significantly lower left atrial total emptying volume, and left atrial active ejection fraction (8.93 ± 1.86 vs. 9.60 ± 2.29 cm3/m2 and 23 ± 2.56 vs. 31.19 ± 1.66 %; p<0.001). on comparing strain function, DCM patients had lower systolic (28.22 ± 3.84 vs. 60.87 ± 3.07 %, p<0.001), and left atrial systolic strain rate (-2.66 ± 0.45 vs. -3.81 ± 0.35; p = 0.003) compared to healthy controls. All strains and strain rates were significantly lower in NIDCM patients compared to IDCM patients. Conclusion: STE is a promising method for evaluating LAF in DCM patients. Patients with DCM had significantly lower left atrial systolic and late diastolic strains and strain rates compared to healthy patients. Moreover, NIDCM could be differentiated from IDCM by having more impairment in the LA dynamic reservoir and booster pump function.
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15

Ijuin, Shun, Ali Hamadanchi, Franz Haertel, Laura Baez, PaulChristian Schulze, Marcus Franz, and Sven Moebius-Winkler. "Improvement in left atrial strain among patients undergoing percutaneous left atrial appendage closure." Journal of Cardiovascular Echography 30, no. 1 (2020): 15. http://dx.doi.org/10.4103/jcecho.jcecho_42_19.

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Abd El Rahman, Mohamed, Tanja Raedle-Hurst, Axel Rentzsch, Hans-Joachim Schäfers, and Hashim Abdul-Khaliq. "Assessment of inter-atrial, inter-ventricular, and atrio-ventricular interactions in tetralogy of Fallot patients after surgical correction. Insights from two-dimensional speckle tracking and three-dimensional echocardiography." Cardiology in the Young 25, no. 7 (October 23, 2014): 1254–62. http://dx.doi.org/10.1017/s1047951114002108.

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AbstractBackground: We aimed to assess biatrial size and function, interactions on atrial and ventricular levels, and atrio-ventricular coupling in patients after tetralogy of Fallot repair. Methods: A total of 34 patients with a mean age of 20.9±9 years, and 35 healthy controls, underwent two-dimensional speckle tracking echocardiography for ventricular and atrial strain measurements and real-time three-dimensional echocardiography to assess ventricular and atrial volumes. Results: When compared with controls, tetralogy of Fallot patients had significantly reduced right atrial peak atrial longitudinal strain (p<0.01), right atrial peak atrial contraction strain (p<0.01), right atrial ejection fraction (p<0.01), left atrial peak atrial longitudinal strain (p<0.01), left atrial peak atrial contraction strain (p<0.05), and left atrial ejection fraction (p<0.01). In the tetralogy of Fallot group, left ventricular ejection fraction was negatively related to the right ventricular end-systolic volume normalised to body surface area (r=−0.62, p<0.01). An association was found in patients between the right atrial peak longitudinal strain and mean right ventricular strain (r=0.64, p<0.01). In patients, the left atrial peak longitudinal strain correlated negatively with right atrial end-diastolic volume normalised to body surface area (r=−0.67, p<0.01), whereas the left atrial ejection fraction correlated weakly with left ventricular ejection fraction (r=0.41, p<0.05). Conclusions: In asymptomatic tetralogy of Fallot patients, biatrial dysfunction exists and can be quantified via two-dimensional speckle tracking echocardiography as well as real-time three-dimensional echocardiography. Different forms of interactions on atrial and ventricular levels are evident among such cohorts.
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Park, Jae-Hyeong, Kye Hun Kim, Lawrence Rink, Kyle Hornsby, Jae Yeong Cho, Goo-Yeong Cho, Jae-Hwan Lee, et al. "Left atrial enlargement and its association with left atrial strain in university athletes participated in 2015 Gwangju Summer Universiade." European Heart Journal - Cardiovascular Imaging 21, no. 8 (May 7, 2020): 865–72. http://dx.doi.org/10.1093/ehjci/jeaa084.

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Abstract Aims Intensive and repetitive athletic training may result in cardiac geometric changes, but the determinants of left atrial (LA) enlargement (LAE) has been poorly studied. We investigated incidence and determinants of LAE and its association with LA strains in highly trained university athletes. Methods and results A total of 1073 athletes (451 females, 22.4 ± 2.4 years old) who were able to measure LA size, volume, and strains during 2015 Gwangju Summer Universiade were enrolled. LAE was defined as the increased LA volume index &gt; 42 mL/m2. LA strains, reservoir, conduit, and contractile were measured by 2D speckle tracking method, and LA reservoir strain &lt; 27.6% was considered as abnormal. LAE was developed in 205 athletes (19.1%). In univariate analysis, male [odds ratio (OR) = 1.679], Caucasian (OR = 1.746), non-African descent (OR = 1.804), body muscle mass (OR = 1.056), body fat mass (OR = 0.962), systolic blood pressure (OR = 1.012), heart rate (OR = 0.980), sports type with cardiovascular (CV) demand (OR = 1.474), training time (OR = 1.011), left ventricular (LV) global longitudinal strain (LVGLS, OR = 0.906), and LV stroke volume (LVSV, OR = 1.044) were significantly associated with LAE. In multivariate logistic regression analysis, heart rate (OR = 0.961) and sports type with CV demand (OR = 1.299), LVGLS (OR = 0.865) and LVSV (OR = 1.013) were independent determinants of LAE. Abnormal LA reservoir strain was noted in 56 athletes (5.2%), and the incidence of abnormal value was not different between two groups; 42 athletes (4.8%) in LAE vs. 14 (6.8%) in no LAE group (P = 0.293). Conclusion LAE was common in university athletes (19.1%) and associated with heart rate, sports type with CV demand, LVGLS, and LVSV. Although LAE was significantly associated with the lower LA reservoir strain, the incidence of abnormal value was very low (5.2%) and indifferent between LAE and no LAE group.
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Zhu, Meng-Ruo, Man Wang, Xin-Xin Ma, Dong-Yan Zheng, and Yue-Li Zhang. "The value of left atrial strain and strain rate in predicting left atrial appendage stasis in patients with nonvalvular atrial fibrillation." Cardiology Journal 25, no. 1 (February 27, 2018): 87–96. http://dx.doi.org/10.5603/cj.a2017.0069.

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19

Gan, Gary C. H., Aaisha Ferkh, Anita Boyd, and Liza Thomas. "Left atrial function: evaluation by strain analysis." Cardiovascular Diagnosis and Therapy 8, no. 1 (February 2018): 29–46. http://dx.doi.org/10.21037/cdt.2017.06.08.

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20

Gorcsan, John. "Can Left Atrial Strain Forecast Future Fibrillation?" JACC: Cardiovascular Imaging 14, no. 1 (January 2021): 145–47. http://dx.doi.org/10.1016/j.jcmg.2020.09.012.

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21

Filali, T., I. Ghrissi, P. Barsoum, S. Razkallah, R. Geha, A. Ben Amor, J. Maroni, and F. Walylo. "Left atrial strain for predicting atrial fibrillation in hypertrophic cardiomyopathy." Archives of Cardiovascular Diseases Supplements 12, no. 1 (January 2020): 55–56. http://dx.doi.org/10.1016/j.acvdsp.2019.09.120.

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Król, Wojciech, Ilona Jędrzejewska, Marcin Konopka, Krystyna Burkhard-Jagodzińska, Andrzej Klusiewicz, Andrzej Pokrywka, Jolanta Chwalbińska, et al. "Left Atrial Enlargement in Young High-Level Endurance Athletes – Another Sign of Athlete’s Heart?" Journal of Human Kinetics 53, no. 1 (December 1, 2016): 81–90. http://dx.doi.org/10.1515/hukin-2016-0012.

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AbstractEnlargement of the left atrium is perceived as a part of athlete’s heart syndrome, despite the lack of evidence. So far, left atrial size has not been assessed in the context of exercise capacity. The hypothesis of the present study was that LA enlargement in athletes was physiological and fitness-related condition. In addition, we tried to assess the feasibility and normal values of left atrial strain parameters and their relationship with other signs of athlete’s heart. The study group consisted of 114 international-level rowers (17.5 ± 1.5 years old; 46.5% women). All participants underwent a cardio-pulmonary exercise test and resting transthoracic echocardiography. Beside standard echocardiographic measurements, two dimensional speckle tracking echocardiography was used to assess average peak atrial longitudinal strain, peak atrial contraction strain and early left atrial diastolic longitudinal strain. Mild, moderate and severe left atrial enlargement was present in 27.2°%, 11.4% and 4.4% athletes, respectively. There were no significant differences between subgroups with different range of left atrial enlargement in any of echocardiographic parameters of the left ventricle diastolic function, filling pressure or hypertrophy. A significant correlation was found between the left atrial volume index and maximal aerobic capacity (R > 0.3; p < 0.001). Left atrial strain parameters were independent of atrial size, left ventricle hypertrophy and left ventricle filling pressure. Decreased peak atrial longitudinal strain was observed in 4 individuals (3.5%). We concluded that LA enlargement was common in healthy, young athletes participating in endurance sport disciplines with a high level of static exertion and was strictly correlated with exercise capacity, therefore, could be perceived as another sign of athlete’s heart.
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23

Kuppahally, Suman S., Nazem Akoum, Nathan S. Burgon, Troy J. Badger, Eugene G. Kholmovski, Sathya Vijayakumar, Swati N. Rao, et al. "Left Atrial Strain and Strain Rate in Patients With Paroxysmal and Persistent Atrial Fibrillation." Circulation: Cardiovascular Imaging 3, no. 3 (May 2010): 231–39. http://dx.doi.org/10.1161/circimaging.109.865683.

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24

Tan, Changming, Minzhi OuYang, Demiao Kong, and Xinmin Zhou. "Association Between the Left Atrial and Left Atrial Appendages Systole Strain Rate in Patients with Atrial Fibrillation." Medical Science Monitor 22 (December 18, 2016): 4974–77. http://dx.doi.org/10.12659/msm.901831.

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25

Inoue, Katsuji, Espen Remme, Øyvind Senstad Andersen, Einar Gude, Helge Skulstad, and Otto Smiseth. "LEFT ATRIAL STRAIN AS A SURROGATE MARKER OF ATRIAL CHAMBER STIFFNESS." Journal of the American College of Cardiology 73, no. 9 (March 2019): 1526. http://dx.doi.org/10.1016/s0735-1097(19)32132-1.

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26

Petre, Ioana, Sebastian Onciul, Silvia Iancovici, Diana Zamfir, Monica Stoian, Alina Scărlătescu, Alexandra Diaconeasa, Camelia Acatrinei, and Maria Dorobanțu. "Left Atrial Strain for Predicting Atrial Fibrillation Onset in Hypertensive Patients." High Blood Pressure & Cardiovascular Prevention 26, no. 4 (July 15, 2019): 331–37. http://dx.doi.org/10.1007/s40292-019-00326-4.

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Hoit, B. D., and R. A. Walsh. "Regional atrial distensibility." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 5 (May 1, 1992): H1356—H1360. http://dx.doi.org/10.1152/ajpheart.1992.262.5.h1356.

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We studied 12 open-chest dogs to determine whether there are regional differences in left atrial distensibility. Sonomicrometer crystal pairs were used to measure the anteroposterior diameters of the left atrial body and appendage simultaneously over a wide range of intracardiac pressures and volumes obtained by intravenous saline infusion. Left atrial pressure-natural strain data for the body and appendage were fitted to an exponential function. The mean coefficient of the left atrial monoexponential pressure-strain relationship was greater for the body than appendage (3.1 +/- 1.1 vs. 1.9 +/- 0.7 mmHg, P less than 0.01). The Y-intercepts were not significantly different (5.2 +/- 1.7 vs 4.9 +/- 1.8 mmHg). The maximum minus minimum left atrial dimension, an index of the reservoir function of the atrium, increased with volume infusion in both the body and appendage and was significantly greater in the appendage than body at each level of left atrial pressure. Similarly, atrial systolic shortening fraction increased with volume infusion, and regional shortening was greater in the appendage than the body at each level of left atrial pressure. We conclude that regional differences in atrial distensibility exist in vivo and may play an important role in modulating systolic and diastolic function of the left atrium.
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Shih, Jhih-Yuan, Wei-Chuan Tsai, Yao-Yi Huang, Yen-Wen Liu, Chih-Chan Lin, Liang-Miin Tsai, and Li-Jen Lin. "ASSOCIATION OF DECREASED LEFT ATRIAL STRAIN AND STRAIN RATE WITH STROKE IN CHRONIC ATRIAL FIBRILLATION." Journal of the American College of Cardiology 55, no. 10 (March 2010): A93.E879. http://dx.doi.org/10.1016/s0735-1097(10)60880-7.

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Shih, Jhih-Yuan, Wei-Chuan Tsai, Yao-Yi Huang, Yen-Wen Liu, Chih-Chan Lin, Yu-Shan Huang, Liang-Miin Tsai, and Li-Jen Lin. "Association of Decreased Left Atrial Strain and Strain Rate with Stroke in Chronic Atrial Fibrillation." Journal of the American Society of Echocardiography 24, no. 5 (May 2011): 513–19. http://dx.doi.org/10.1016/j.echo.2011.01.016.

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Yang, Li-Tan, Wei-Chuan Tsai, Chwan-Yau Luo, Yi-Heng Li, and Liang-Miin Tsai. "Role of Left Atrial Reservoir Strain Rate in Left Atrial Remodeling in Severe Mitral Regurgitation." Journal of Medical Ultrasound 25, no. 1 (March 2017): 16–23. http://dx.doi.org/10.1016/j.jmu.2016.09.003.

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31

Miyoshi, Akihito, Yoichi Nakamura, Yukio Kazatani, and Hiroshi Ito. "The feasibility of substituting left atrial wall strain for flow velocity of left atrial appendage." Acta Cardiologica 73, no. 2 (July 28, 2017): 125–30. http://dx.doi.org/10.1080/00015385.2017.1351242.

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32

Cameli, Mateli. "Left atrial strain in patients with arterial hypertension." International Cardiovascular Forum Journal 1, no. 1 (March 29, 2015): 31. http://dx.doi.org/10.17987/icfj.v1i1.12.

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<p><span>Background: </span>Arterial hypertension (HTN) causes left ventricular (LV) cavity dysfunction even if ejection function (EF) remains preserved. Recent studies have shown that diastolic dysfunction and left atrial (LA) dilatation are also associated with myocardial dysfunction. The aim of the present study was to explore the nature of LA longitudinal function disturbances in hypertensive patients with normal LV and LA structure and conventional function parameters.</p><p><span>Methods: </span>Peak atrial longitudinal strain (PALS) was evaluated in 78 patients with systemic HTN and preserved EF (≥ 55%) divided in 41 patients with diastolic dysfunction but no hypertrophy (group HTNdd), and 37 patients with no diastolic dysfunction or hypertrophy (group eHTN). Results were compared with those from 38 age and gender-matched healthy controls.</p><p><span>Results: </span>Indexed LA area and indexed LA volume were within the normal range and not different between the two patient groups and controls. eHTN group had reduced global PALS (p &lt; 0.001) and four-and two-chamber average PALS (p &lt; 0.001 for both). Similar abnormalities were seen in HTNdd group but to a worse degree (P &lt; 0.01 for both). LV EF was not different between the eHTN and HTNdd groups compared to controls. LV E/e’ ratio was the strongest predictor of reduced global PALS in both eHTN and HTNdd groups.</p><p><span>Conclusion: </span>Asymptomatic untreated HTN patients with preserved LVEF and normal diastolic function have compromised LA strain despite normal cavity size, consistent with preclinical LA myocardial dysfunction.</p>
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33

Romano, Giuseppe, Giuseppe Raffa, Diego Bellavia, Michele Pilato, and Francesco Clemenza. "Left Atrial Longitudinal Strain at the Conduit Phase." Transplantation 102 (July 2018): S119. http://dx.doi.org/10.1097/01.tp.0000542725.19394.15.

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34

Lima, João A. C., and Bharath Ambale-Venkatesh. "Left Atrial Strain to Address the Cryptogenic Puzzle." JACC: Cardiovascular Imaging 11, no. 11 (November 2018): 1566–68. http://dx.doi.org/10.1016/j.jcmg.2017.08.020.

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35

Backhaus, Sören Jan, and Andreas Schuster. "Atrial Strain Assessment in Left Ventricular Diastolic Dysfunction." JACC: Cardiovascular Imaging 11, no. 1 (January 2018): 154. http://dx.doi.org/10.1016/j.jcmg.2017.10.016.

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Ciampi, Quirino, and Eugenio Picano. "Left atrial strain: a new window on left ventricular filling pressure?" International Cardiovascular Forum Journal 1, no. 1 (March 29, 2015): 3. http://dx.doi.org/10.17987/icfj.v1i1.6.

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37

Gold, Andrew K., Jesse J. Kiefer, Jared W. Feinman, and John G. Augoustides. "Left Atrial Strain—A Valuable Window on Left Ventricular Diastolic Function." Journal of Cardiothoracic and Vascular Anesthesia 35, no. 6 (June 2021): 1626–27. http://dx.doi.org/10.1053/j.jvca.2021.02.010.

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Koyama, Jun, Hirohiko Motoki, Kazunori Aizawa, Megumi Koshikawa, Hiroki Kasai, Atsushi Izawa, Takeshi Tomita, Yusuke Miyashita, Setsuo Kumazaki, and Uichi Ikeda. "IMPROVEMENT OF LONGITUDINAL LEFT VENTRICULAR STRAIN IS ASSOCIATED WITH LEFT ATRIAL STRAIN ENHANCEMENT AFTER PULMONARY-VEIN ISOLATION FOR ATRIAL FIBRILLATION." Journal of the American College of Cardiology 55, no. 10 (March 2010): A30.E284. http://dx.doi.org/10.1016/s0735-1097(10)60285-9.

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39

Lee, Dong Hyun, Tae-Ho Park, Jung Eun Lee, Young-Rak Cho, Kyungil Park, Jong Sung Park, Moo-Hyun Kim, and Young-Dae Kim. "Left Atrial Function Assessed by Left Atrial Strain in Patients with Left Circumflex Branch Culprit Acute Myocardial Infarction." Echocardiography 32, no. 7 (November 3, 2014): 1094–100. http://dx.doi.org/10.1111/echo.12828.

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40

Gabrielli, Luigi, Ramon Corbalan, Samuel Córdova, Andrés Enríquez, Paul Mc Nab, Hugo E. Verdejo, Iván Godoy, Ricardo Zalaquett, and Sergio Lavandero. "Left Atrial Dysfunction Is a Predictor of Postcoronary Artery Bypass Atrial Fibrillation: Association of Left Atrial Strain and Strain Rate Assessed by Speckle Tracking." Echocardiography 28, no. 10 (October 4, 2011): 1104–8. http://dx.doi.org/10.1111/j.1540-8175.2011.01518.x.

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41

Kurosawa, K., K. Negishi, R. Tateno, K. Masuda, M. Obokata, Y. Houjou, M. Nakajima, and M. Kurabayashi. "Relationship left atrial strain and CHA2DS2-VASc score compared to left atrial appendage emptying flow velocity." European Heart Journal 34, suppl 1 (August 2, 2013): 2024. http://dx.doi.org/10.1093/eurheartj/eht308.2024.

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42

Verma, Aditya, Saroj Mandal, Sankar C. Mandal, Sidhnath Singh, Suvendu Chattopadhyay, and Apurba B. Pramanick. "LEFT ATRIAL STRAIN IMAGING IN MITRAL STENOSIS PATIENTS AS A PREDICTOR OF LEFT ATRIAL APPENDAGEAL THROMBOSIS." Journal of the American College of Cardiology 77, no. 18 (May 2021): 1425. http://dx.doi.org/10.1016/s0735-1097(21)02783-2.

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43

Rasmussen, Sif Maja Aas, Flemming Javier Olsen, Peter Godsk Jørgensen, Thomas Fritz-Hansen, Thomas Jespersen, Gunnar Gislason, and Tor Biering-Sørensen. "Utility of left atrial strain for predicting atrial fibrillation following ischemic stroke." International Journal of Cardiovascular Imaging 35, no. 9 (April 26, 2019): 1605–13. http://dx.doi.org/10.1007/s10554-019-01601-0.

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44

Thomas, L., T. Mckay, K. Byth, and T. H. Marwick. "Abnormalities of left atrial function after cardioversion: an atrial strain rate study." Heart 93, no. 1 (January 1, 2007): 89–95. http://dx.doi.org/10.1136/hrt.2006.088609.

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45

Sarvari, Sebastian I., Kristina H. Haugaa, Thomas M. Stokke, Hamza Z. Ansari, Ida S. Leren, Finn Hegbom, Otto A. Smiseth, and Thor Edvardsen. "Strain echocardiographic assessment of left atrial function predicts recurrence of atrial fibrillation." European Heart Journal – Cardiovascular Imaging 17, no. 6 (July 27, 2015): 660–67. http://dx.doi.org/10.1093/ehjci/jev185.

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46

Tops, Laurens F., Victoria Delgado, Matteo Bertini, Nina Ajmone Marsan, Dennis W. Den Uijl, Serge A. I. P. Trines, Katja Zeppenfeld, Eduard Holman, Martin J. Schalij, and Jeroen J. Bax. "Left Atrial Strain Predicts Reverse Remodeling After Catheter Ablation for Atrial Fibrillation." Journal of the American College of Cardiology 57, no. 3 (January 2011): 324–31. http://dx.doi.org/10.1016/j.jacc.2010.05.063.

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47

Ble, Mireia, Begoña Benito, Elisa Cuadrado-Godia, Sílvia Pérez-Fernández, Miquel Gómez, Aleksandra Mas-Stachurska, Helena Tizón-Marcos, Lluis Molina, Julio Martí-Almor, and Mercè Cladellas. "Left Atrium Assessment by Speckle Tracking Echocardiography in Cryptogenic Stroke: Seeking Silent Atrial Fibrillation." Journal of Clinical Medicine 10, no. 16 (August 9, 2021): 3501. http://dx.doi.org/10.3390/jcm10163501.

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Abstract:
Silent atrial fibrillation (AF) may be the cause of some cryptogenic strokes (CrS). The aim of the study was to analyse atrial size and function by speckle tracking echocardiography in CrS patients to detect atrial disease. Patients admitted to the hospital due to CrS were included prospectively. Echocardiogram analysis included left atrial ejection fraction (LAEF) and atrial strain. Insertable cardiac monitor was implanted, and AF was defined as an episode of ≥1 min in the first year after stroke. Left atrial enlargement was defined as indexed volume > 34 mL/m2. Seventy-five consecutive patients were included, aged 76 ± 9 years (arterial hypertension 75%). AF was diagnosed in 49% of cases. The AF group had higher atrial volume and worse atrial function: peak atrial longitudinal strain (PALs) 19.6 ± 5.7% vs. 29.5 ± 7.2%, peak atrial contraction strain (PACs) 8.9 ± 3.9% vs. 16.5 ± 6%, LAEF 46.8 ± 11.5% vs. 60.6 ± 5.2%; p < 0.001. AF was diagnosed in 20 of 53 patients with non-enlarged atrium, and in 18 of them, atrial dysfunction was present. The multivariate logistic regression analysis demonstrated an independent association between detection of AF and atrial volume, LAEF, and strain. Cut-off values were obtained: LAEF < 55%, PALs < 21.4%, and PACs < 12.9%. In conclusion, speckle tracking echocardiography in CrS patients improves silent atrial disease diagnosis, with or without atrial enlargement.
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Tayal, Bhupendar, Maan Malahfji, John M. Buergler, Dipan J. Shah, and Sherif F. Nagueh. "Hemodynamic determinants of left atrial strain in patients with hypertrophic cardiomyopathy: A combined echocardiography and CMR study." PLOS ONE 16, no. 2 (February 10, 2021): e0245934. http://dx.doi.org/10.1371/journal.pone.0245934.

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Background Left atrial (LA) strain is associated with symptomatic status and atrial fibrillation in patients with hypertrophic cardiomyopathy (HCM). However, hemodynamic determinants of LA reservoir (LARS), conduit, and pump strains have not been examined and data are needed on the relation of LA strain with exercise tolerance in HCM. Methods Fifty HCM patients with echocardiographic and CMR imaging within 30 days were included. Left ventricular (LV) volumes, mass, EF, scar extent, extracellular volume fraction (ECV), and LA maximum volume were measured by CMR. Echo studies were analyzed for mitral inflow, pulmonary vein flow, mitral annulus tissue Doppler velocities, LV global longitudinal strain, and LA strain. Twenty six patients able and willing to exercise underwent cardiopulmonary stress testing for peak oxygen consumption (MVO2), and VE/VCO2 slope. Patients were followed for clinical events. Findings LARS was significantly associated with indices of LA systolic function, LV GLS, and LV filling pressures (P<0.05). Conduit strain was significantly associated with mitral annulus early diastolic velocity and ECV, whereas LA pump strain was determined by LA systolic function and indices of LV end diastolic pressure (all P<0.05). LARS and conduit strain were significantly higher in patients who achieved ≥80% of MVO2. LARS, conduit, and pump strains were significantly associated with atrial fibrillation (P<0.05). Conclusions LV structure, systolic and diastolic function, and LA systolic function determine the 3 components of LA strain. LA strain is associated with exercise tolerance and clinical events in patients with HCM.
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De Maat, Gijs E., Stefano Benussi, Yoran M. Hummel, Sebastien Krul, Alberto Pozzoli, Antoine H. G. Driessen, Massimo A. Mariani, Isabelle C. Van Gelder, Wim-Jan Van Boven, and Joris R. de Groot. "Surgical Left Atrial Appendage Exclusion Does Not Impair Left Atrial Contraction Function: A Pilot Study." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/318901.

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Background. In order to reduce stroke risk, left atrial appendage amputation (LAAA) is widely adopted in recent years. The effect of LAAA on left atrial (LA) function remains unknown. The objective of present study was to assess the effect of LAAA on LA function.Methods. Sixteen patients with paroxysmal AF underwent thoracoscopic, surgical PVI with LAAA (LAAA group), and were retrospectively matched with 16 patients who underwent the same procedure without LAA amputation (non-LAAA group). To objectify LA function, transthoracic echocardiography with 2D Speckle Tracking was performed before surgery and at 12 months follow-up.Results. Mean age was 57 ± 9 years, 84% were male. Baseline characteristics did not differ significantly except for systolic blood pressure (p=0.005). In both groups, the contractile LA function and LA ejection fraction were not significantly reduced. However, the conduit and reservoir function were significantly decreased at follow-up, compared to baseline. The reduction of strain and strain rate was not significantly different between groups.Conclusions. In this retrospective, observational matched group comparison with a convenience sample size of 16 patients, findings suggest that LAAA does not impair the contractile LA function when compared to patients in which the appendage was unaddressed. However, the LA conduit and reservoir function are reduced in both the LAAA and non-LAAA group. Our data suggest that the LAA can be removed without late LA functional consequences.
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50

Ferkh, A., S. Trivedi, L. Stefani, P. Brown, F. Pathan, and L. Thomas. "Multivendor Analysis of Left Atrial Strain using Multilayer Analysis." Heart, Lung and Circulation 28 (2019): S259. http://dx.doi.org/10.1016/j.hlc.2019.06.293.

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