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1

Čulo, Marija, and Marija Renić. "Left ventricular assist device." Cardiologia Croatica 11, no. 10-11 (November 2016): 572. http://dx.doi.org/10.15836/ccar2016.572.

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2

Frigerio, Maria. "Left Ventricular Assist Device." Heart Failure Clinics 17, no. 4 (October 2021): 619–34. http://dx.doi.org/10.1016/j.hfc.2021.05.007.

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3

Robson, Desiree. "Heartmate - left ventricle assist device." Nursing Standard 10, no. 9 (November 22, 1995): 52–53. http://dx.doi.org/10.7748/ns.10.9.52.s55.

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4

Bond, A. Elaine, Karl Nelson, Cara Lynn Germany, and Angie N. Smart. "The Left Ventricular Assist Device." AJN, American Journal of Nursing 103, no. 1 (January 2003): 32–40. http://dx.doi.org/10.1097/00000446-200301000-00018.

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5

Long, J. W., W. Dembitsky, R. Khodaverdian, A. J. Powers, and R. Adamson. "Left ventricular assist device replacement." Journal of Heart and Lung Transplantation 22, no. 1 (January 2003): S83—S84. http://dx.doi.org/10.1016/s1053-2498(02)00706-4.

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6

Kormos, Robert L., Michael McCall, Andrew Althouse, Luigi Lagazzi, Richard Schaub, Michael A. Kormos, Jared A. Zaldonis, et al. "Left Ventricular Assist Device Malfunctions." Circulation 136, no. 18 (October 31, 2017): 1714–25. http://dx.doi.org/10.1161/circulationaha.117.027360.

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7

Smietana, Jeffrey. "Left Ventricular Assist Device Artifact." Circulation 142, no. 7 (August 18, 2020): 705–7. http://dx.doi.org/10.1161/circulationaha.120.049195.

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8

O’Horo, John C., Omar M. Abu Saleh, John M. Stulak, Mark P. Wilhelm, Larry M. Baddour, and M. Rizwan Sohail. "Left Ventricular Assist Device Infections." ASAIO Journal 64, no. 3 (2018): 287–94. http://dx.doi.org/10.1097/mat.0000000000000684.

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9

Simpson, Martha, Rosemary Luquire, Linda Dewitt, and Vicki Draper. "TCI Left Ventricular Assist Device." Dimensions Of Critical Care Nursing 9, no. 6 (November 1990): 318–26. http://dx.doi.org/10.1097/00003465-199011000-00002.

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10

Horton, Steven C., Reza Khodaverdian, Peter Chatelain, Marsha L. McIntosh, Benjamin D. Horne, Joseph B. Muhlestein, and James W. Long. "Left Ventricular Assist Device Malfunction." Journal of the American College of Cardiology 45, no. 9 (May 2005): 1435–40. http://dx.doi.org/10.1016/j.jacc.2005.01.037.

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11

Lindenfeld, JoAnn, and Mary E. Keebler. "Left Ventricular Assist Device Thrombosis." JACC: Heart Failure 3, no. 2 (February 2015): 154–58. http://dx.doi.org/10.1016/j.jchf.2014.12.001.

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12

Park, Ilkun, Yang Hyun Cho, Su Ryeun Chung, Dong Seop Jeong, Kiick Sung, Wook Sung Kim, and Young Tak Lee. "Temporary Right Ventricular Assist Device Insertion via Left Thoracotomy after Left Ventricular Assist Device Implantation." Korean Journal of Thoracic and Cardiovascular Surgery 52, no. 2 (April 5, 2019): 105–8. http://dx.doi.org/10.5090/kjtcs.2019.52.2.105.

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13

Schechter, Matthew A., Chetan B. Patel, Joseph G. Rogers, and Carmelo A. Milano. "Temporary extracorporeal left ventricular assist device support for implantable left ventricular assist device replacement cases." Journal of Thoracic and Cardiovascular Surgery 147, no. 4 (April 2014): e46-e48. http://dx.doi.org/10.1016/j.jtcvs.2013.12.009.

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14

Thyagarajan, Braghadheeswar, Monisha Priyadarshini Kumar, Rutuja R. Sikachi, and Abhinav Agrawal. "Endocarditis in left ventricular assist device." Intractable & Rare Diseases Research 5, no. 3 (2016): 177–84. http://dx.doi.org/10.5582/irdr.2016.01049.

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15

Clement, Alexandra, Larisa Anghel, Radu Sascău, and Cristian Stătescu. "Left Ventricular Assist Device-Related Complications." Journal Of Cardiovascular Emergencies 6, no. 3 (September 1, 2020): 50–58. http://dx.doi.org/10.2478/jce-2020-0014.

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AbstractLeft ventricular assist device (LVAD) has emerged as a safe, durable, and revolutionary therapy for end-stage heart failure patients. Despite the appearance of newer-generation devices that have improved patient outcomes, the burden of adverse events remains significant. Although the survival rate for patients with LVAD is appreciated to be 81% at 1 year and 70% at 2 years, the incidence of adverse events is also high. Over time, both early and late postimplant complications have diminished in terms of prevalence and impact; however, complications, such as infections, bleeding, right heart failure, pump thrombosis, aortic insufficiency, or stroke, continue to represent a challenge for the practitioner. Therefore, the aim of this review is to highlight the most recent data regarding the current use of LVAD in the treatment of end-stage heart failure, with a specific focus on LVAD-related complications, in order to improve device-related outcomes. It will also revise how to mitigate the risk and how to approach specific adverse events. Withal, understanding the predisposing risk factors associated with postimplant complications, early recognition and appropriate treatment help to significantly improve the prognosis for patients with end-stage heart failure.
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16

Angud, Marc. "Left Ventricular Assist Device Driveline Infections." AACN Advanced Critical Care 26, no. 4 (October 1, 2015): 300–305. http://dx.doi.org/10.4037/nci.0000000000000108.

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Heart failure is a chronic progressive disease that affects millions of people in the United States. Although medical management of heart failure has helped improve quality of life and survival, end-stage heart failure ultimately requires a heart transplant or long-term left ventricular assist device (LVAD) support. With more patients awaiting transplant, the demand for hearts outweighs the supply of donor hearts. The use of LVADs is increasing in patients with advanced heart failure as a treatment option for those awaiting a heart transplant or as a long-term solution if they are ineligible for a transplant. Although the LVAD is a marvel of modern medicine, infection is a cause of concern because today’s LVADs are powered externally through a percutaneous driveline that can be a major source of infection.
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17

Helmy, SherifM, Alia Albinali, and Rachel Hajar. "Echocardiography in left ventricular assist device." Heart Views 11, no. 2 (2010): 74. http://dx.doi.org/10.4103/1995-705x.73222.

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18

Devine, Alicia. "Troubleshooting the Left Ventricular Assist Device." Emergency Medicine 48, no. 2 (February 1, 2016): 58–63. http://dx.doi.org/10.12788/emed.2016.0012.

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19

Voorhees, Hannah J., Erik N. Sorensen, Chetan Pasrija, Francesca M. Boulos, Si M. Pham, Bartley P. Griffith, and Zachary N. Kon. "Minimally Invasive Left Ventricular Assist Device." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 13, no. 3 (May 2018): 218–21. http://dx.doi.org/10.1097/imi.0000000000000505.

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Objective Several centers have presented minimally invasive surgical approaches to centrifugal left ventricular assist device implantation. Although minimally invasive implantation has been successfully performed by experienced surgeons, at large implanting centers, it is unknown whether these techniques are widely adoptable. We evaluated the experience of a surgeon early in his career with conventional and minimally invasive approaches to device implantation. Methods All consecutive left ventricular assist device implantations by a single surgeon in the first year of practice (2015–2016) were retrospectively reviewed. Patients were stratified by standard approach, conventional full sternotomy versus a minimally invasive approach, left anterior thoracotomy and upper hemisternotomy. Demographics, perioperative variables, and short-term outcomes were compared using Wilcoxon rank-sum test. Results Thirteen patients were identified: six performed via the standard approach and seven performed via the minimally invasive approach. Preoperative demographics were comparable in both groups. However, there was significantly more preoperative right ventricle dysfunction in the minimally invasive group ( P = 0.01). Although operative time was significantly longer in the minimally invasive cohort, there was a trend toward decreased cardiopulmonary bypass time. Six-month survival in both groups was 100%. Conclusions Compared with conventional sternotomy, minimally invasive ventricular assist device implantation, performed by a surgeon in his first year of practice, had similar perioperative outcomes and excellent survival. Based on these data, minimally invasive implantation may be a feasible strategy for device implantation even early in a surgeon's career.
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20

Ersoy, Ozgur, Bahadir Gultekin, Sarp Beyazpinar, Elif Sade, Atilla Sezgin, and Sait Aslamaci. "Left Ventricular Assist Device Management Strategy." Transplantation 102 (July 2018): S831. http://dx.doi.org/10.1097/01.tp.0000543882.63211.4d.

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21

Skubas, Nikolaos J., Mary Hyder, Michael Pasque, Eric Ruocco, and Demetrios G. Lappas. "Left ventricular assist device: Hemodynamic profile." Journal of Cardiothoracic and Vascular Anesthesia 14, no. 6 (December 2000): 751–52. http://dx.doi.org/10.1053/jcan.2000.18640.

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22

Camp, Debi. "The Left Ventricular Assist Device (LVAD)." Critical Care Nursing Clinics of North America 12, no. 1 (March 2000): 61–68. http://dx.doi.org/10.1016/s0899-5885(18)30124-2.

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23

Bhat, Anusha Ganapati, Osama Kandalaft, Sheila Shoemaker, and Mara Slawsky. "LEFT VENTRICULAR ASSIST DEVICE GASTRIC EROSION." Journal of the American College of Cardiology 73, no. 9 (March 2019): 2491. http://dx.doi.org/10.1016/s0735-1097(19)33097-9.

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24

Nurozler, Feza, Michael Argenziano, Mehmet C. Oz, and Yoshifumi Naka. "Fungal left ventricular assist device endocarditis." Annals of Thoracic Surgery 71, no. 2 (February 2001): 614–18. http://dx.doi.org/10.1016/s0003-4975(00)01444-2.

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25

Speiser, Bernadette S. "Percutaneously Implanted Left Ventricular Assist Device." Dimensions of Critical Care Nursing 30, no. 5 (September 2011): 236–40. http://dx.doi.org/10.1097/dcc.0b013e3182276f0c.

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26

Angud, Marc. "Left Ventricular Assist Device Driveline Infections." AACN Advanced Critical Care 26, no. 4 (2015): 300–305. http://dx.doi.org/10.1097/nci.0000000000000108.

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27

Westaby, Stephen. "A new left ventricular assist device." Bulletin of the Royal College of Surgeons of England 101, suppl_4 (September 2019): 8–15. http://dx.doi.org/10.1308/rcsbull.2019.m2.

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28

TSUBOUCHI, Takeshi. "Introduciton of Left Ventricle Assist Device." Journal of the Society of Mechanical Engineers 113, no. 1099 (2010): 446–47. http://dx.doi.org/10.1299/jsmemag.113.1099_446.

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29

Voorhees, Hannah J., Erik N. Sorensen, Chetan Pasrija, Francesca M. Boulos, Si M. Pham, Bartley P. Griffith, and Zachary N. Kon. "Minimally Invasive Left Ventricular Assist Device." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 13, no. 3 (May 2018): 218–21. http://dx.doi.org/10.1177/155698451801300310.

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30

LaRue, Shane, Anthony Shanks, I.-wen Wang, Gregory Ewald, Diane Anderson, and Susan Joseph. "Left Ventricular Assist Device in Pregnancy." Obstetrics & Gynecology 118, no. 2, Part 2 (August 2011): 426–28. http://dx.doi.org/10.1097/aog.0b013e31820fcdaf.

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31

Bellumkonda, Lavanya, Lakshman Subrahmanyan, Daniel Jacoby, and Pramod Bonde. "Left Ventricular Assist Device Pump Thrombosis." ASAIO Journal 60, no. 1 (2014): 134–36. http://dx.doi.org/10.1097/mat.0000000000000028.

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32

Ting, Lai Shiau, Chang Shiao Hwang, Yu Tarng Jenn, and Shih Chun Che. "HeartMate Implantable Left Ventricular Assist Device." Asian Cardiovascular and Thoracic Annals 5, no. 3 (September 1997): 171–73. http://dx.doi.org/10.1177/021849239700500312.

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A 19-year-old male with acute myocarditis, cardiogenic shock, and impending multiple organ failure successfully underwent emergency implantation of a HeartMate WOO IP left ventricular assist device. The perioperative course was uneventful and his condition improved. After 14 weeks his cardiac function gradually recovered and heart transplantation was no longer considered necessary. The left ventricular assist device was explanted. Two weeks later the patient suffered a sudden onset of ventricular fibrillation and died in spite of aggressive resuscitation measures. Questions concerning the future use of such assist devices in patients with cardiomyopathy are discussed.
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33

Frazier, O. H. "Thermo cardiosystems left ventricular assist device." Annals of Thoracic Surgery 54, no. 5 (November 1992): 1019. http://dx.doi.org/10.1016/0003-4975(92)90683-u.

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34

Pereda, Daniel, and John V. Conte. "Left Ventricular Assist Device Driveline Infections." Cardiology Clinics 29, no. 4 (November 2011): 515–27. http://dx.doi.org/10.1016/j.ccl.2011.08.004.

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35

Teuteberg, Jeffrey J., Mark S. Slaughter, Joseph G. Rogers, Edwin C. McGee, Francis D. Pagani, Robert Gordon, Eduardo Rame, et al. "The HVAD Left Ventricular Assist Device." JACC: Heart Failure 3, no. 10 (October 2015): 818–28. http://dx.doi.org/10.1016/j.jchf.2015.05.011.

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36

Califano, Sophia, Francis D. Pagani, and Preeti N. Malani. "Left Ventricular Assist Device–Associated Infections." Infectious Disease Clinics of North America 26, no. 1 (March 2012): 77–87. http://dx.doi.org/10.1016/j.idc.2011.09.008.

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37

Siddique, Aleem, Neil Wrightson, Guy A. Macgowan, and Stephan Schueler. "Device Thrombosis in the HeartWare Left Ventricular Assist Device." Annals of Thoracic Surgery 95, no. 4 (April 2013): 1508. http://dx.doi.org/10.1016/j.athoracsur.2012.10.011.

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38

Yoshioka, Daisuke, Taichi Sakaguchi, Shunsuke Saito, Shigeru Miyagawa, Hiroyuki Nishi, Yasushi Yoshikawa, Satsuki Fukushima, Takayoshi Ueno, Toru Kuratani, and Yoshiki Sawa. "Initial Experience of Conversion of Toyobo Paracorporeal Left Ventricular Assist Device to DuraHeart Left Ventricular Assist Device." Circulation Journal 76, no. 2 (2012): 372–76. http://dx.doi.org/10.1253/circj.cj-11-0833.

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39

Imamura, Teruhiko, Koichiro Kinugawa, Minoru Ono, Norihide Fukushima, Akira Shiose, Yoshiro Matsui, Kenji Yamazaki, et al. "Bridge-to-Bridge Left Ventricular Assist Device Implantation Strategy vs. Primary Left Ventricular Assist Device Implantation Strategy." Circulation Journal 84, no. 12 (November 25, 2020): 2198–204. http://dx.doi.org/10.1253/circj.cj-20-0840.

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40

Kormos, Robert L. "Extending the perspective on left ventricular assist device pump thrombosis to left ventricular assist device system thrombosis." Journal of Thoracic and Cardiovascular Surgery 155, no. 1 (January 2018): e37-e38. http://dx.doi.org/10.1016/j.jtcvs.2017.09.079.

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41

Raichel, Lior, Edward Wang, and Christopher Merry. "Left Ventricular Assist Device Explantation via Left Anterolateral Thoracotomy." Heart, Lung and Circulation 28 (2019): S118. http://dx.doi.org/10.1016/j.hlc.2019.02.149.

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42

Imanishi, Kaoru, Kou Imachi, Hiroshi Yoshito, Takashi Isoyama, Yusuke Abe, Tsuneo Chinzei, Kunihiko Mabuchi, et al. "A Percutaneously Accessible Pulsatile Left Ventricular Assist Device: Modified Assist Device Type 5." Artificial Organs 20, no. 2 (November 12, 2008): 147–51. http://dx.doi.org/10.1111/j.1525-1594.1996.tb00718.x.

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43

Graefe, Roland, Andreas Henseler, Reiner Körfer, Bart Meyns, and Libera Fresiello. "Influence of left ventricular assist device pressure-flow characteristic on exercise physiology: Assessment with a verified numerical model." International Journal of Artificial Organs 42, no. 9 (May 20, 2019): 490–99. http://dx.doi.org/10.1177/0391398819846126.

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Current left ventricular assist devices are designed to reestablish patient’s hemodynamics at rest but they lack the suitability to sustain the heart adequately during physical exercise. Aim of this work is to assess the performance during exercise of a left ventricular assist device with flatter pump pressure-flow characteristic and increased pressure sensitivity (left ventricular assist device 1) and to compare it to the performance of a left ventricular assist device with a steeper characteristic (left ventricular assist device 2). The two left ventricular assist devices were tested at constant rotational speed with a verified computational cardiorespiratory simulator reproducing an average left ventricular assist device patient response to exercise (EXE↑) and a left ventricular assist device patient with no chronotropic and inotropic response (EXE→). According to the results, left ventricular assist device 1 pumps a higher flow than left ventricular assist device 2 both at EXE↑ (6.3 vs 5.6 L/min) and at EXE→ (6.7 vs 6.1 L/min), thus it better unloads the left ventricle. Left ventricular assist device 1 increases the power delivered to the circulation from 0.63 W at rest to 0.67 W at EXE↑ and 0.82 W at EXE→, while left ventricular assist device 2 power shows even a minimal decrease. Left ventricular assist device 1 better sustains exercise hemodynamics and can provide benefits in terms of exercise performance, especially for patients with a poor residual left ventricular function, for whom the heart can hardly accommodate an increase of cardiac output.
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44

Aissaoui, Nadia, Jerome Jouan, Melissa Gourjault, Benoit Diebold, Sofia Ortuno, Amer Hamdan, Christian Latremouille, Romain Pirracchio, and Michiel Morshuis. "Understanding Left Ventricular Assist Devices." Blood Purification 46, no. 4 (2018): 292–300. http://dx.doi.org/10.1159/000491872.

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Background/Aims: Long-term mechanical assist devices are now commonly used in the treatment of severe heart failure to unload the failing ventricle, maintain sufficient end-organ perfusion and improve functional capacity. Depending on the assisted ventricles, 3 categories of long-term assist devices are available: left ventricular assist device (LVAD), biventricular assist device and total artificial heart. Improvements in technology, especially the advent of smaller, durable continuous flow pumps, have led to the use of LVADs in a much broader population of patients in the last 10 years. Both the number of patients living with LVADs and the life expectancy of these patients are increasing. Regarding this growing number of patients with LVAD, intensivists need to understand the physiology of the devices, their functioning, potential complications and their management. Methods: We performed a narrative review of relevant medical literature regarding the physiology of patients with LVAD and management of common complications relevant to the critical care physicians. Results: The most frequent complications occurring in the LVAD patients after the post-operative period are bleeding, driveline infections, thrombosis, device malfunction, right ventricular failure and arrhythmias. Bleeding is the most frequent adverse event in LVAD due to a combination of anticoagulation and acquired von Willebrand disease secondary to shear stress produced within the pump. Their management includes antiplatelet therapy arrest, reduction of the anticoagulation regimen and specific therapy if feasible. Infection is the second most common cause of death after cardiac failure in LVAD patients. All infections must be aggressively treated to avoid seeding the device. Device thrombosis can develop even when patients are adequately anticoagulated and taking antiplatelet therapy because the LVAD is responsible for a chronic hypercoagulable state. Conclusion: Management of these unique patients in the ICU is best accomplished with a multidisciplinary team that includes specialists in advanced heart failure, LVAD nurse coordinators and intensivists.
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45

From, Robert P., David Hasan, Michael T. Froehler, and Jennifer L. Goerbig-Campbell. "Stroke and Left Ventricular Assist Device (LVAD)." Open Journal of Anesthesiology 03, no. 01 (2013): 51–56. http://dx.doi.org/10.4236/ojanes.2013.31014.

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46

McCarthy, Patrick M. "Implantable Left Ventricular Assist Device Insertion Techniques." Operative Techniques in Thoracic and Cardiovascular Surgery 4, no. 4 (November 1999): 277–300. http://dx.doi.org/10.1016/s1522-2942(07)70124-1.

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47

Weeks, Phillip, Adam Sieg, Indranee Rajapreyar, Sriram Nathan, Marwan Jumean, Manish Patel, Rajko Radovancevic, Biswajit Kar, and Igor Gregoric. "Bivalirudin for left ventricular assist device thrombosis." Journal of Thrombosis and Thrombolysis 46, no. 4 (August 17, 2018): 496–501. http://dx.doi.org/10.1007/s11239-018-1725-z.

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48

Ashraf, Omer. "Left ventricular assist device in heart failure." Journal of Thoracic and Cardiovascular Surgery 131, no. 5 (May 2006): 1211–12. http://dx.doi.org/10.1016/j.jtcvs.2005.12.050.

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49

Southerland, Kevin W., and Carmelo A. Milano. "Heart Transplantation After Left Ventricular Assist Device." Operative Techniques in Thoracic and Cardiovascular Surgery 19, no. 1 (2014): 47–63. http://dx.doi.org/10.1053/j.optechstcvs.2014.03.003.

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50

Cheung, Anson, Jia-Lin Soon, Jamil Bashir, Annemarie Kaan, and Andrew Ignaszewski. "Minimal-Access Left Ventricular Assist Device Implantation." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 9, no. 4 (July 2014): 281–85. http://dx.doi.org/10.1097/imi.0000000000000086.

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Objective The left ventricular assist device (LVAD) is typically implanted through a full sternotomy on cardiopulmonary bypass (CPB). Minimally invasive surgery (MIS) modifications include multiple smaller incisions, using “virgin” territory, and minimized CPB time. Methods Forty-two LVAD implantations were retrospectively reviewed. Twenty-five minimally invasive implantations (MIS, 20 HeartMate II and 5 HeartWare) were compared with 17 sternotomy implantations (12 HeartMate II and 5 HeartWare). The choice of MIS incisions was device dependent: (1) three separate incisions for the HeartMate II or (2) two incisions for the HeartWare device. Four HeartWare LVADs were implanted off-pump (three using the MIS approach). Results The median patient age was 52 years (range, 18–69 years). Overall survival was 81% at a mean (SD) follow-up of 495 (375) days. Thirty-day mortality was 9.5% (one MIS and three sternotomy patients). Five patients (11.9%) died while on LVAD, 18 (42.9%) underwent transplantation, 6 (14.3%) underwent weaning and explantation, and 13 (31.0%) remained on support. Preoperative ventilatory and circulatory supports were more common in the sternotomy group. The MIS patients had shorter CPB time [51.4 (34.9) vs 83.6 (40.4) minutes, P = 0.014] and showed a trend toward lower red blood cell and platelet transfusion requirement. The durations of hospitalization, inotropic support, intensive care unit stay, and LVAD support were not significantly different. Conclusions Minimally invasive surgery LVAD implantation is feasible. The shorter CPB duration and off-pump approach may be advantageous. Avoiding sternotomy may also reduce adhesions encountered during subsequent cardiac transplantation.
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