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Dissertations / Theses on the topic 'Legionnaires' Disease Mathematical models'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Wilmot, Peter Nicholas. "Modelling cooling tower risk for Legionnaires' Disease using Bayesian Networks and Geographic Information Systems." Title page, contents and conclusion only, 1999. http://web4.library.adelaide.edu.au/theses/09SIS.M/09sismw744.pdf.

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Includes bibliographical references (leaves 115-120) Establishes a Bayesian Belief Network (BBN) to model uncertainty of aerosols released from cooling towers and Geographic Information Systems (GIS) to create a wind dispersal model and identify potential cooling towers as the source of infection. Demonstrates the use of GIS and BBN in environmental epidemiology and the power of spatial information in the area of health.

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2

Roberts, Paul Allen. "Mathematical models of the retina in health and disease." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:385f61c4-4ff1-45d3-bdb2-41338c174025.

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The retina is the ocular tissue responsible for the detection of light. Its extensive demand for oxygen, coupled with a concomitant elevated supply, renders this tissue prone to both hypoxia and hyperoxia. In this thesis, we construct mathematical models of the retina, formulated as systems of reaction-diffusion equations, investigating its oxygen-related dynamics in healthy and diseased states. In the healthy state, we model the oxygen distribution across the human retina, examining the efficacy of the protein neuroglobin in the prevention of hypoxia. It has been suggested that neuroglobin co

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3

Oduro, Bismark. "Mathematical Models of Triatomine (Re)infestation." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1458563770.

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4

Zhang, Xu-Sheng. "Mathematical models of plant disease epidemics that involve virus interactions." Thesis, University of Greenwich, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327341.

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5

Bell, Sally Sue. "Mathematical models assessing the importance of disease on ecological invasions." Thesis, Heriot-Watt University, 2010. http://hdl.handle.net/10399/2316.

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A general understanding of the role that both shared disease and competition may play in ecological invasions is lacking. We develop a theoretical framework to determine the role of disease, in addition to competition, in invasions. We first investigate the e ect of disease characteristics on the replacement time of a native species by an invader. The outcome is critically dependent on the relative e ects that the disease has on the two species and less dependent on the basic epidemiological characteristics of the interaction. This framework is extended to investigate the e ect of disease on t

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6

Korobeinikov, Andrei. "Stability and bifurcation of deterministic infectious disease models." Thesis, University of Auckland, 2001. http://wwwlib.umi.com/dissertations/fullcit/3015611.

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Autonomous deterministic epidemiological models are known to be asymptotically stable. Asymptotic stability of these models contradicts observations. In this thesis we consider some factors which were suggested as able to destabilise the system. We consider discrete-time and continuous-time autonomous epidemiological models. We try to keep our models as simple as possible and investigate the impact of different factors on the system behaviour. Global methods of dynamical systems theory, especially the theory of bifurcations and the direct Lyapunov method are the main tools of our analysis.

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7

Ning, Yao, and 宁耀. "The use of stochastic models of infectious disease transmission for public health: schistosomiasis japonica." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4553097X.

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8

Bingham, Adrienna N. "Controlling Infectious Disease: Prevention and Intervention Through Multiscale Models." W&M ScholarWorks, 2019. https://scholarworks.wm.edu/etd/1582642581.

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Controlling infectious disease spread and preventing disease onset are ongoing challenges, especially in the presence of newly emerging diseases. While vaccines have successfully eradicated smallpox and reduced occurrence of many diseases, there still exists challenges such as fear of vaccination, the cost and difficulty of transporting vaccines, and the ability of attenuated viruses to evolve, leading to instances such as vaccine derived poliovirus. Antibiotic resistance due to mistreatment of antibiotics and quickly evolving bacteria contributes to the difficulty of eradicating diseases such

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9

Kwong, Kim-hung, and 鄺劍雄. "Spatio-temporal transmission modelling of an infectious disease: a case study of the 2003 SARS outbreak in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45693900.

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10

Venkatachalam, Sangeeta. "Modeling Infectious Disease Spread Using Global Stochastic Field Simulation." Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5335/.

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Susceptibles-infectives-removals (SIR) and its derivatives are the classic mathematical models for the study of infectious diseases in epidemiology. In order to model and simulate epidemics of an infectious disease, a global stochastic field simulation paradigm (GSFS) is proposed, which incorporates geographic and demographic based interactions. The interaction measure between regions is a function of population density and geographical distance, and has been extended to include demographic and migratory constraints. The progression of diseases using GSFS is analyzed, and similar behavior to t

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11

Lutambi, Angelina Mageni. "Basic properties of models for the spread of HIV/AIDS." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/19641.

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Thesis (MSc)--University of Stellenbosch, 2007.<br>ENGLISH ABSTRACT: While research and population surveys in HIV/AIDS are well established in developed countries, Sub-Saharan Africa is still experiencing scarce HIV/AIDS information. Hence it depends on results obtained from models. Due to this dependence, it is important to understand the strengths and limitations of these models very well. In this study, a simple mathematical model is formulated and then extended to incorporate various features such as stages of HIV development, time delay in AIDS death occurrence, and risk groups. Th

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12

Ejigu, Amsalework Ayele. "Mathematical modelling of HIV/AIDS transmission under treatment structured by age of infection." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6628.

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Thesis (MSc (Mathematical Sciences))--University of Stellenbosch, 2011.<br>Includes bibliography.<br>ENGLISH ABSTRACT: This thesis takes into account the different levels of infectiousness of the human immunodeficiency virus (HIV) infected individuals throughout their period of infection. Infectiousness depends on the time since infection. It is high shortly after the infection occurs and then much lower for several years, and thereafter a higher plateau is reached before the acquired immunodeficiency syndrome (AIDS) phase sets in. In line with this, we formulated a mathematical model whi

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13

Thompson, Brett Morinaga. "Development, Implementation, and Analysis of a Contact Model for an Infectious Disease." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc9824/.

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With a growing concern of an infectious diseases spreading in a population, epidemiology is becoming more important for the future of public health. In the past epidemiologist used existing data of an outbreak to help them determine how an infectious disease might spread in the future. Now with computational models, they able to analysis data produced by these models to help with prevention and intervention plans. This paper looks at the design, implementation, and analysis of a computational model based on the interactions of the population between individuals. The design of the working conta

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14

Kwok, Kin-on, and 郭健安. "Models of directly transmitted respiratory pathogens in hospitals and households." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40687557.

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15

Porter, Rosalyn. "Mathematical models of a tick borne disease in a British game bird with potential management strategies." Thesis, University of Stirling, 2011. http://hdl.handle.net/1893/3039.

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Louping ill virus (LIV) is a tick borne disease that causes mortality in red grouse, an economically important game bird of British uplands. The aim of this thesis is to extend previously published models of LIV , to consider the potential impact of different management strategies. In addition a new route of infection and the seasonal biology of both grouse and ticks will be explored. Grouse chicks are known to eat ticks as part of their diet in the first three weeks of life which may contribute to virus persistence if chicks consume infected ticks. This novel route of infection is incorporate

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16

Worton, Adrian J. "Using mathematical models to understand the impact of climate change on tick-borne infections across Scotland." Thesis, University of Stirling, 2016. http://hdl.handle.net/1893/24918.

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Ticks are of global interest as the pathogens they spread can cause diseases that are of importance to both human health and economies. In Scotland, the most populous tick species is the sheep tick Ixodes ricinus, which is the vector of pathogens causing diseases such as Lyme borreliosis and Louping-ill. Recently, both the density and spread of I. ricinus ticks have grown across much of Europe, including Scotland, increasing disease risk. Due to the nature of the tick lifecycle they are particularly dependent on environmental factors, including temperature and habitat type. Because of this, th

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17

Holgado, Alejo J. "Construction and study of mathematical models firmly based on neurophysiological data to investigate Parkinson's disease and epilepsy." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540899.

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18

Fino, Angela. "A mathematical macroscopic model for the onset and progression of Alzheimer's disease." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/17130/.

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In this work we deal with the study of a macroscopic mathematical model which describes the onset and progression of Alzheimer’s disease (AD) in the human brain. In particular, we analyze in detail the well-posedness of the model itself. The model is based on the so-called “amyloid cascade hypothesis” together with the “prionoid hypothesis”, which represents the spreading of the disease through neuron-to-neuron transmission. In particular, from a mathematical point of view, the model consists of a transport equation for a probability measure, coupled with a nonlinear Smoluchowski-type system w

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19

Fiorentino, Francesca. "Mathematical models of the impact of rabbit calicivirus disease (RCD) on the European rabbit, Oryctolagus cuniculus, in Australia." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446810/.

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This thesis relates to the work of building a mathematical model of the impact of Rabbit Calicivirus Disease (RCD) on the European Rabbit, Oryctolagus cuniculus, in Australia. After introducing the general biology of rabbits and the immunology of RCD, we build a time-dependent single site model. We construct a single-site population dynamic model with age structure, seasonal birth rate, density dependent regulation of the population size and climatic variability for various regions of Australia. After investigating suitable parameter ranges, we incorporate the disease dynamics through an indir

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20

Yu, Peng, and 于朋. "Air pollution and respiratory disease incidence of Guangzhou: a study of spatial interpolation methodsusing GIS, 2003-2004." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41633799.

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21

Rosà, Roberto. "The importance of aggregation in the dynamics of host-parasite interaction in wildlife : a mathematical approach." Thesis, University of Stirling, 2003. http://hdl.handle.net/1893/50.

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This study examines, from a modelling point of view, the dynamics of infectious diseases in wildlife caused by macroparasites and by tick-borne infections. The overall aim was to investigate the important role played by parasite aggregation in the dynamics of both systems. For macroparasites we first developed some deterministic models that incorporate explicit mechanisms for generating aggregation in parasite distribution, specifically multiple infections and host heterogeneity. We explored the role of aggregation in host regulation and in determining a threshold value for parasite establishm

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22

Gutierrez, Louis Michael. "Agent-based simulation of disease spread aboard ship." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2005. http://library.nps.navy.mil/uhtbin/hyperion/05Mar%5FGutierrez.pdf.

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Thesis (M.S. in Modeling, Virtual Environments and Simulations (MOVES))--Naval Postgraduate School, March 2005.<br>Thesis Advisor(s): Chris Darken. Includes bibliographical references (p. 47-48). Also available online.

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23

Ireland, Jillian M. "Using mathematical models to determine the effect of seasonal host birth rates on population dynamics of infectious disease systems." Thesis, University of Stirling, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440776.

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24

O'Neill, II Martin Joseph. "Computational Epidemiology - Analyzing Exposure Risk: A Deterministic, Agent-Based Approach." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc11017/.

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Many infectious diseases are spread through interactions between susceptible and infectious individuals. Keeping track of where each exposure to the disease took place, when it took place, and which individuals were involved in the exposure can give public health officials important information that they may use to formulate their interventions. Further, knowing which individuals in the population are at the highest risk of becoming infected with the disease may prove to be a useful tool for public health officials trying to curtail the spread of the disease. Epidemiological models are needed

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25

Corley, Courtney D. "Modeling the Impact and Intervention of a Sexually Transmitted Disease: Human Papilloma Virus." Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5289/.

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Many human papilloma virus (HPV) types are sexually transmitted and HPV DNA types 16, 18, 31, and 45 account for more than 75% if all cervical dysplasia. Candidate vaccines are successfully completing US Federal Drug Agency (FDA) phase III testing and several drug companies are in licensing arbitration. Once this vaccine become available it is unlikely that 100% vaccination coverage will be probable; hence, the need for vaccination strategies that will have the greatest reduction on the endemic prevalence of HPV. This thesis introduces two discrete-time models for evaluating the effect of d

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26

Shi, Zhenzhen. "A MARKOV DECISION PROCESS EMBEDDED WITH PREDICTIVE MODELING: A MODELING APPROACH FROM SYSTEM DYNAMICS MATHEMATICAL MODELS, AGENT-BASED MODELS TO A CLINICAL DECISION MAKING." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/20578.

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Doctor of Philosophy<br>Department of Industrial & Manufacturing Systems Engineering<br>David H. Ben-Arieh<br>Chih-Hang Wu<br>Patients who suffer from sepsis or septic shock are of great concern in the healthcare system. Recent data indicate that more than 900,000 severe sepsis or septic shock cases developed in the United States with mortality rates between 20% and 80%. In the United States alone, almost $17 billion is spent each year for the treatment of patients with sepsis. Clinical trials of treatments for sepsis have been extensively studied in the last 30 years, but there is no general

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Yu, Xiaohong, and 于曉紅. "Hemodynamic analysis of blood flows in carotid bifurcations." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3864700X.

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28

Liu, Jie. "Novel Bayesian Methods for Disease Mapping: An Application to Chronic Obstructive Pulmonary Disease." Link to electronic thesis, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-0501102-110350.

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Thesis (M.S.)--Worcester Polytechnic Institute.<br>Keywords: latent class model; Poisson regression model; Metropolis-Hastings sampler; order restriction; disease mapping. Includes bibliographical references.

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29

Majeke, Lunga. "Preliminary investigation into estimating eye disease incidence rate from age specific prevalence data." Thesis, University of Fort Hare, 2011. http://hdl.handle.net/10353/464.

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This study presents the methodology for estimating the incidence rate from the age specific prevalence data of three different eye diseases. We consider both situations where the mortality may differ from one person to another, with and without the disease. The method used was developed by Marvin J. Podgor for estimating incidence rate from prevalence data. It delves into the application of logistic regression to obtain the smoothed prevalence rates that helps in obtaining incidence rate. The study concluded that the use of logistic regression can produce a meaningful model, and the incidence

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30

Chen, Yao-Hsuan. "Network modeling of sexually transmitted diseases." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51883.

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We create a dynamic network model to replicate more closely the population network structures of interest. Network, Norms and HIV/STI Risk Among Youth (NNAHRAY) is a community relationship survey data set, which provides a rare sample of a human risky-behavior contact network. Combining disease compartmental models with our dynamic network model, we simulate the spread of Human Immunodeficiency Virus (HIV) and Herpes Simplex Type 2 Virus (HSV2) with consideration of HSV2's synergistic impact on HIV's transmission. Our model reproduces HIV prevalence, HSV-2 prevalence, and the contact network c

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McBryde, Emma Sue. "Mathematical and statistical modelling of infectious diseases in hospitals." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16330/.

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Antibiotic resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant enterococci (VRE), are an increasing burden on healthcare systems. Hospital acquired infections with these organisms leads to higher morbidity and mortality compared with the sensitive strains of the same species and both VRE and MRSA are on the rise worldwide including in Australian hospitals. Emerging community infectious diseases are also having an impact on hospitals. The Severe Acute Respiratory Syndrome virus (SARS Co-V) was noted for its propensity to spread throughout ho

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Njagarah, Hatson John Boscoh. "Modelling the role of amelioration and drug lords on drug epidemics and the impact of substance abuse on the dynamics of HIV/AIDS." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/17935.

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Thesis (MSc)--Stellenbosch University, 2011.<br>ENGLISH ABSTRACT: Substance abuse is an imminent danger on the health of both substance users and nonusers. In general, abuse of psychoactive substances is associated with high risk behaviour, mortality and morbidity. The drug use cycle involves inextricably intertwined variants such as production, trading and usage of both licit and illicit addictive substances. The dynamics of substance use involve initiation, addiction, rehabilitation/treatment and quitting/ recovery. In response to supply and abuse of monster drugs, control strategies su

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33

Mannan, Haider Rashid. "Development and use of a Monte Carlo-Markov cycle tree model for coronary heart disease incidence-mortality and health service usage with explicit recognition of coronary artery revascularization procedures (CARPs)." University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0101.

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[Truncated abstract] The main objective of this study was to develop and validate a demographic/epidemiologic Markov model for population modelling/forecasting of CARPs as well as CHD deaths and incidence in Western Australia using population, linked hospital morbidity and mortality data for WA over the period 1980 to 2000. A key feature of the model was the ability to count events as individuals moved from one state to another and an important aspect of model development and implementation was the method for estimation of model transition probabilities from available population data. The mode

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34

Bierman, Anandi. "Mapping and survey sequencing of Dn resistance genes in Triticum aestivum L." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96912.

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Thesis (PhD)--Stellenbosch University, 2015<br>ENGLISH ABSTRACT : Diuraphis noxia Kurdjumov (Russian Wheat Aphid; RWA) is a pest of wheat and barley that has spread from its home range in the fertile crescent to most wheat producing countries except Australia. Since its first introduction to South Africa and the USA in the late 20th century, breeding programs for wheat phenotypes resistant to the aphid were put in place. Conventional breeding practices rely on phenotypic screening to verify traits carried by offspring and genetic tools such as marker assisted selection (MAS) have greatly aide

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35

Santos, Dayana Lardo dos. "Zoneamento da favorabilidade climática para a ocorrência da ferrugem alaranjada da cana-de-açúcar nas principais regiões produtoras do Brasil e da Austrália." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/11/11152/tde-21082013-104149/.

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O Brasil, maior expoente do setor sucroalcooleiro mundial, apresenta como um dos entraves para obter elevadas produtividades a ocorrência de doenças fúngicas, as quais limitam o potencial produtivo do canavial. Atualmente, um dos grandes desafios para a comunidade canavieira é a recém-introduzida ferrugem alaranjada, doença causada pelo fungo Puccinia kuehnii, a qual foi detectada pela primeira vez no Brasil na safra 2009/10, ano em que as chuvas excederam os valores normais e as temperaturas foram amenas. Dada a grande dependência que as doenças fúngicas têm das condições climáticas para se m

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Bruce, Faikah. "Understanding the impact of an HIV intervention package for adolescents." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85666.

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Thesis (MSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Adolescents are regarded as a high risk group in South Africa with the highest human immunodeficiency virus (HIV) incidence occurring in this group. Prevention among adolescents is therefore a key in decreasing the HIV burden. This thesis aims to assist in the design of trials by simulating the potential outcomes of a combination prevention trial in adolescents. We develop a stochastic individual-based model stratified by sex and age. We then use this model to determine the impact of various prevention packages on HIV inci

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El-Bouri, Wahbi K. "Multi-scale modelling of the microvasculature in the human cerebral cortex." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:8a9409a6-6279-4f7b-a975-b70149732378.

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Cerebrovascular diseases are by far the largest causes of death in the UK, as well as one of the leading causes of adult disability. The brain's healthy function depends on a steady supply of oxygen, delivered through the microvasculature. Cerebrovascular diseases, such as stroke and dementia, can interrupt the transport of blood (and hence oxygen) rapidly, or over a prolonged period of time. An interruption in flow can lead to ischaemia, with prolonged interruptions leading to tissue death and eventual brain damage. The microvasculature plays a key role in the transport of oxygen and nutrient

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Crescencio, Julio César. "Quantificação do limiar de anaerobiose ventilatório no exercício físico dinâmico em cardiopatas chagásicos utilizando-se métodos visuais e computacionais." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-06082007-201626/.

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Os avanços tecnológicos ocorridos na última década trouxeram enormes benefícios, no sentido de possibilitar o uso de equipamentos computadorizados, que permitem a aquisição, processamento e armazenamento de um grande número de variáveis respiratórias e metabólicas em exercício físico, em tempo real e a cada ciclo respiratório. Inserido neste novo cenário, o estudo realizado com esta nova geração de equipamentos, nas respectivas áreas de conhecimento, pôde ser direcionado, usando-se métodos matemáticos e estatísticos computadorizados, os quais possibilitam a aplicação de procedimentos automátic

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Behlau, Franklin. "Epidemiologia do cancro cítrico (Xanthomonas axonopodis pv. citri) em laranja 'Pêra' (Citrus sinensis) sob condições de controle químico e cultural." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/11/11135/tde-22082006-153211/.

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O cancro cítrico, causado pela bactéria Xanthomonas axonopodis pv. citri, é uma das doenças mais importantes da citricultura. O estudo do efeito de medidas alternativas de controle para o manejo desta doença assume grande importância tanto para áreas citrícolas onde a erradicação de plantas não é a principal medida de controle do cancro cítrico, como no Estado do Paraná, como para regiões onde a prática da erradicação vem sendo adotada como principal medida de controle da doença, como no Estado de São Paulo. Instalado em pomar citrícola do município de Ourizona, na região Noroeste do Estado do

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40

Kean, J. M. "Metapopulation theory in practice." Lincoln University, 1999. http://hdl.handle.net/10182/1372.

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A metapopulation is defined as a set of potential local populations among which dispersal may occur. Metapopulation theory has grown rapidly in recent years, but much has focused on the mathematical properties of metapopulations rather than their relevance to real systems. Indeed, barring some notable exceptions, metapopulation theory remains largely untested in the field. This thesis investigates the importance of metapopulation structure in the ‘real world’, firstly by building additional realism into metapopulation models, and secondly through a 3-year field study of a real metapopulation s

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Takaidza, Isaac. "Modelling the optimal efficiency of industrial labour force in the presence of HIV/AIDs pandemic." Thesis, Cape Peninsula University of Technology, 2012. http://hdl.handle.net/20.500.11838/1305.

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Thesis (DTech (Mechanical Engineering))--Cape Peninsula University of Technology, 2012<br>In this thesis, we investigate certain key aspects of mathematical modelling to explain the epidemiology of HIV/AIDS at the workplace and to assess the potential benefits of proposed control strategies. Deterministic models to investigate the effects of the transmission dynamics of HIV/AIDS on labour force productivity are formulated. The population is divided into mutually exclusive but exhaustive compartments and a system of differential equations is derived to describe the spread of the epidemic. The q

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Molina, Martínez Patricia. "Desarrollo de modelos celulares para estudios terapéuticos en la enfermedad de Alzheimer." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/385986.

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La enfermedad de Alzheimer (EA) es la causa más común de demencia neurodegenerativa en los países desarrollados y su prevalencia aumenta con la edad. Los genes cuyas mutaciones son responsables de EA familiar son APP, PSEN1 y PSEN2, las mutaciones en PSEN1 siendo las más frecuentes. La mayoría de los casos son de EA esporádica y la edad es el principal factor de riesgo. Los mecanismos implicados en el envejecimiento del cerebro que contribuyen a la aparición de la EA aún no se han desentrañado, pero probablemente incluyen la disfunción mitocondrial, el estrés oxidativo y la inflamación cerebra

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Rivas, Cruz Manuel A. "Medical relevance and functional consequences of protein truncating variants." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:a042ca18-7b35-4a62-aef0-e3ba2e8795f7.

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Genome-wide association studies have greatly improved our understanding of the contribution of common variants to the genetic architecture of complex traits. However, two major limitations have been highlighted. First, common variant associations typically do not identify the causal variant and/or the gene that it is exerting its effect on to influence a trait. Second, common variant associations usually consist of variants with small effects. As a consequence, it is more challenging to harness their translational impact. Association studies of rare variants and complex traits may be able to h

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Salmani, Mahin. "A model for disease transmission in a patchy environment." 2005. http://hdl.handle.net/1828/826.

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Dovzhenok, Andrey A. "Mathematical Models of Basal Ganglia Dynamics." 2013. http://hdl.handle.net/1805/3357.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Physical and biological phenomena that involve oscillations on multiple time scales attract attention of mathematicians because resulting equations include a small parameter that allows for decomposing a three- or higher-dimensional dynamical system into fast/slow subsystems of lower dimensionality and analyzing them independently using geometric singular perturbation theory and other techniques. However, in most life sciences applications observed dynamics is extremely complex, no small parameter exists and this approach fails. Neve

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Roldan, Josiah Javier. "West Nile virus : forecasting models for a resurging vector-borne disease in Arizona, U.S.A." Thesis, 2012. http://hdl.handle.net/1957/35783.

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West Nile Virus (WNV), a vector-borne disease continues to be a serious threat to public health in the United States, particularly in the Southwest region. While all the states in the U.S. experienced a decreasing trend of WNV disease in 2010, the state of Arizona experienced a sharp increase from 20 in 2009 to 166 cases the following year. This dissertation endeavored to develop forecasting models to predict future cases of disease and identify counties with increased propensity for WNV. Furthermore, this study aimed to identify environmental and economic factors that contributed to the i

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"Dynamics and Implications of Data-Based Disease Models in Public Health and Agriculture." Doctoral diss., 2016. http://hdl.handle.net/2286/R.I.41234.

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abstract: The increased number of novel pathogens that potentially threaten the human population has motivated the development of mathematical and computational modeling approaches for forecasting epidemic impact and understanding key environmental characteristics that influence the spread of diseases. Yet, in the case that substantial uncertainty surrounds the transmission process during a rapidly developing infectious disease outbreak, complex mechanistic models may be too difficult to be calibrated quick enough for policy makers to make informed decisions. Simple phenomenological models tha

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Mann, Joanne L. "Modelling infectious disease epidemiology and vaccination impact : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Mathematics at Massey University, Albany, New Zealand." 2009. http://hdl.handle.net/10179/1085.

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This thesis presents mathematical models for the dynamics of vaccine preventable diseases, specifically looking at the New Zealand situation. Through the use of integral and differential equations, we develop models and compare the results of these to known data. Using game theory analysis we determine and compare the proportion of the population that needs to be vaccinated in order to minimise the expected costs to the individuals in the population and to the community. Two different scenarios and methods are considered, where the effects of vaccination last only one epidemic cycle (using an

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Jain, Ravi 1967. "Intelligent techniques for the diagnosis of coronary artery disease / Ravi Jain." 1998. http://hdl.handle.net/2440/19356.

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Bibliography: leaves 179-190.<br>xii, 189 leaves : ill. ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>This thesis proposes a genetic-programming-based classifier system for the diagnosis of coronary artery disease. Based on genetic programming, a software system called Evolutionary Pre-Processor has been developed as a new method for the automatic extraction of non-linear features for supervised classification. Two different hybrid intelligent system techniques are presented; fuzzy systems integrated with gene

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Mugisha, Stella. "Applied mathematical modelling with new parameters and applications to some real life problems." Thesis, 2018. http://hdl.handle.net/10500/24973.

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Some Epidemic models with fractional derivatives were proved to be well-defined, well-posed and more accurate [34, 51, 116], compared to models with the conventional derivative. An Ebola epidemic model with non-linear transmission is fully analyzed. The model is expressed with the conventional time derivative with a new parameter included, which happens to be fractional (that derivative is called the 􀀀derivative). We proved that the model is well-de ned and well-posed. Moreover, conditions for boundedness and dissipativity of the trajectories are established. Exploiting the generalized Routh

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