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Journal articles on the topic 'Lei 14.532/2023'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Zhou, Feng, Lu Liu, Lei Jiang та ін. "Abstract 512: Identification of SS008871, a novel Polθ inhibitor that effectively inhibits tumors with homologous recombination deficiency in vitro and in vivo". Cancer Research 83, № 7_Supplement (2023): 512. http://dx.doi.org/10.1158/1538-7445.am2023-512.

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Abstract The repair of DNA double strand break (DSB) is crucial for genome stability and cell survival. There are three main DSB repair pathways: homologous recombination (HR), non-homologous end joining (NHEJ) and microhomology-mediated end joining (MMEJ). HR is a high-fidelity, error-free DSB repair pathway, and the dysfunction of HR confers cell genome instability and leads to tumorigenesis. HR deficiency is especially prevalent in gynecologic tumors, sharing about 10% population of all the gynecologic tumor patients. In situation of HR deficiency, MMEJ, in which DNA polymerase theta (Polθ)

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Gou, Xuxu, Junkai Wang, Jonathan T. Lei, Eric J. Jaehnig, and Meenakshi Anurag. "Abstract 1460: Co-expression network analysis reveals male breast cancer specific transcriptional module." Cancer Research 83, no. 7_Supplement (2023): 1460. http://dx.doi.org/10.1158/1538-7445.am2023-1460.

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Abstract Introduction: According to the American Cancer Society, An estimated 2,710 men are diagnosed with breast cancer annually of which about 530 die due to the disease annually in the United States. Most male breast tumors are estrogen receptor positive. Risk factors include age, radiation exposure, BRCA1/2 gene mutations, Klinefelter syndrome, testicular disorders, diabetes, gynecomastia (enlarged breast) etc. Due to low testing and incidence rate and lack of bioinformatics approaches focused on identification of drivers of rare cancer, little is known about this disease in men than in wo

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Leontiev, E. A., G. Yu Struchko, V. A. Kozlov, A. L. Fedorov, and T. Yu Leontyeva. "Dependence of light absorption on temperature changes in tattoo pigments." Laser Medicine 27, no. 1 (2023): 34–38. http://dx.doi.org/10.37895/2071-8004-2023-27-1-34-38.

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Purpose: to study the quantitative intensity of optical density and light absorption of the electromagnetic radiation with tattoo pigment aqueous solution depending on its temperature.Material and methods. One hundred twenty-three of the most common commercial tattoo pigments were selected for the trial; 369 samples of aqueous solutions were made of them. Optical density of each pigment sample was determined at 14 and 77 °C. Then, each sample was exposed to optical radiation (IPL xenon lamp with pulsed light) at 14 and 77 °C.Results and discussion. Electromagnetic radiation with wavelengths 53

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Costa, Edgard Gonçalves da. "A proteção de dados pessoais de crianças e adolescentes." JURIS - Revista da Faculdade de Direito 33, no. 2 (2024): 71–89. http://dx.doi.org/10.14295/juris.v33i2.16562.

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A Lei Geral de Proteção de Dados Pessoais (LGPD) é considerada uma lei guarda-chuva, visto ser uma norma que apenas propõe-se a apresentar regramentos gerais relacionados à proteção de dados pessoais. Este normativo previu que autoridade específica encarregar-se-ia de elaborar as diretrizes de proteção e privacidade correspondentes a dados pessoais, com a incumbência, ainda, de elaborar regulamentos, fiscalizar o cumprimento da lei e aplicar penalidades, inclusive de caráter pecuniário. Assim, foi criada a Agência Nacional de Proteção de Dados Pessoais (ANPD). O Art. 31, § 5º, da Lei de Acesso

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Grant, Alex, and Colm O'Dwyer. "Operando Raman Spectroscopy of Phase Changes in Nanocrystalline Metal Oxide Lithium-Ion Battery Electrodes." ECS Meeting Abstracts MA2022-02, no. 1 (2022): 94. http://dx.doi.org/10.1149/ma2022-02194mtgabs.

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As the demands for clean electricity, transport and highly functional portable electronics grow faster than ever, energy storage remains the main roadblock to progression. Electrochemical devices such as lithium-ion batteries (LIBs), have been the source of most success in overcoming this roadblock. The primary issue with these devices is lifetime decay due primarily to the degradation of the electrodes within the battery. Nanocrystalline materials are often chosen,1 which enhance battery performance by reducing ion diffusion lengths and thus improving rate capabilities. However, structural ch

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Abrão, Luciano. "A RESPONSABILIZAÇÃO OBJETIVA, SOLIDÁRIA E DISCRIMINATÓRIA DE ASSOCIAÇÃO CIVIL: Uma análise parcial da Lei Geral do Esporte, pelo prisma do controle de constitucionalidade." UNESC em Revista 8, no. 1 (2024): 66–86. http://dx.doi.org/10.54578/unesc.v8i1.461.

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Esta pesquisa tem por objetivo a realização de uma análise discursiva da Lei Geral do Esporte (Lei nº 14.597, de 14 de junho de 2023), por intermédio dos filtros teórico-metodológicos do controle de constitucionalidade, e, nesse sentido, comprovar hipóteses que, conforme pormenorizaremos, convertem-se em inconstitucionalidade material dos parágrafos 5º e 6º, do seu artigo 178, em razão da instituição de uma espécie de “Desconsideração Legislativa Abstrata da Personalidade Jurídica” com efeitos sobre uma única modalidade de Associação Civil, bem como uma inequívoca (e não menos exótica) Respons

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Ding, Lei, Yanjie Li, Mariska ter Haak та Lawrence Lamb. "Abstract 1777: A non-signaling CAR for gamma-delta (γδ) T cells to preserve healthy tissues". Cancer Research 83, № 7_Supplement (2023): 1777. http://dx.doi.org/10.1158/1538-7445.am2023-1777.

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Abstract Chimeric antigen receptor T cell (CAR-T) therapy for B cell leukemias and lymphomas have shown remarkable responses in the clinic. However, the elimination of all cells expressing target antigen including healthy tissues by CAR-T cells is a significant safety concern. Such on-target off-tumor toxicities are problematic for many types of cancer antigens and in some cases have resulted in patient deaths. There is a need to address these limitations and develop better and safer next generation CAR-T therapies as we move beyond these tumor types. γδ T cells can directly identify and kill

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Costa, Sebastião Patrício Mendes da, Olívia Brandão Melo Campelo, and Luana Azerêdo Alves. "O ESTUPRO BILATERAL DE VULNERÁVEL À LUZ DA PROTEÇÃO INTEGRAL E DA HERMENÊUTICA JURÍDICA." Revista Brasileira de Direitos e Garantias Fundamentais 9, no. 1 (2023): 59. http://dx.doi.org/10.26668/indexlawjournals/2526-0111/2023.v9i1.9693.

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O presente artigo analisou o estupro cometido contra pessoa menor de 14 (catorze) anos de idade, no contexto anterior e posterior à lei nº 12.015/09, que acrescentou o art. 217-A ao Código Penal, e à lei nº 13.718/18, que acrescentou o § 5º ao art. 217-A do Código Penal. O art. 217-A, § 5º, do Código Penal, tipifica o estupro de vulnerável e preconiza a vulnerabilidade absoluta da pessoa com idade inferior a 14 (catorze) anos. Trata-se de um artigo de revisão, que se caracteriza pela análise e discussão de informações que já estão publicadas. O seu objetivo delimitou-se a analisar a incidência

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Costa, Eduarda Barbosa de Miranda, Francisca Jordania Ferreira da Silva, Maria Eduarda Siqueira de Sousa Fontinele, and Bento Viana de Sousa Neto. "A IMPLEMENTAÇÃO DA NOTIFICAÇÃO OBRIGATÓRIA PELOS CARTÓRIOS DE REGISTRO CIVIL NO ESTADO DO PIAUÍ COM BASE NA LEI ESTADUAL N° 7.985/2023: UM ESTUDO DE CASO SOBRE OS DESAFIOS E OS IMPACTOS NA PROTEÇÃO DOS DIREITOS DE MENORES DE 14 ANOS NA PRÁTICA FORENSE DA COMARCA DE FLORIANO – PIAUÍ." Revista Ibero-Americana de Humanidades, Ciências e Educação 10, no. 12 (2024): 2683–99. https://doi.org/10.51891/rease.v10i12.17569.

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O presente artigo tem por finalidade realizar um estudo aprofundado sobre a implementação da Lei Estadual nº 7.985/2023, sancionada pelo Estado do Piauí, que entrou em vigor em fevereiro de 2023, na comarca de Floriano-PI, bem como inferir sobre a sua efetividade na proteção de menores em decorrência do aumento dos casos de estupro de vulneráveis no estado e no município. A referida lei possui o escopo de garantir a proteção dessas menores e dispõe sobre a obrigatoriedade dos cartórios de registro civil notificarem às autoridades competentes sobre os casos em que as genitoras sejam menores de

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Lee, Jieun, Jung Eun Kim, Sanjun Lee, et al. "Abstract 5322: High throughput chemotherapeutic drug screening system for gastric cancer: cure-GA." Cancer Research 83, no. 7_Supplement (2023): 5322. http://dx.doi.org/10.1158/1538-7445.am2023-5322.

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Abstract To discover clinically applicable anticancer drugs and predict therapeutic response for advanced gastric cancer, we developed a high-throughput drug (HTD) screening system that could rapidly evaluate drug reactivity using 3D cultured primary cells derived from gastric cancer (GC) patients. Primary cancer cells were isolated from fresh surgical specimens that resected from 143 GC patients using Gentle Max tissue dissociation system. Primary cells were mixed with Matrigel, and placed on a micropillar for three-dimensional (3D) culture. After the primary cells were stabilized in the comp

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Gabriela, De Almeida Silva, and Carlos de Sousa Gomes Junior Antônio. "OS ÓRFÃOS DO FEMINICÍDIO: UMA ANÁLISE DA LEI Nº 14.717/2023." Revistaft 28, no. 134 (2024): 72. https://doi.org/10.5281/zenodo.11424672.

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Este estudo analisa a Lei nº 14.717/2023, que institui a pensão especial aos filhos e dependentes órfãos em decorrência do feminicídio, com foco na proteção e amparo dessas vítimas indiretas da violência de gênero. O objetivo deste estudo é avaliar a interpretação, aplicação e impacto da Lei nº 14.717/2023 na proteção e assistência aos órfãos do feminicídio, identificando desafios, lacunas e áreas de melhoria na legislação

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Probst, Lothar. "Die Bürgerschaftswahl in Bremen vom 14. Mai 2023: SPD wieder stärkste Partei, Rot-Grün-Rot wird fortgesetzt." Zeitschrift für Parlamentsfragen 54, no. 3 (2023): 532–53. http://dx.doi.org/10.5771/0340-1758-2023-3-532.

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After a rather boring election campaign the Social-Democrats (SPD) managed to achieve the position of the strongest party again which they lost to the Christian-Democrats (CDU) in 2019 . The CDU and the Left Party defended more or less their last election results whereas the Greens came up with a loss of more than five per cent of the votes . Apparently, the performance of the Greens in the three-party-coalition with the SPD and the Left Party obtained only low credit by the voters . With 5,1 per cent the Liberals were very close to enter the parliament . The SPD as the strongest party invited

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Kristian, Petr, and Dalibor Cholevík. "Laser Therapy of Retinal Tears." Czech and Slovak Ophthalmology 79, no. 3 (2023): 126–33. http://dx.doi.org/10.31348/2023/18.

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Aim: To report the clinical results of treatment of patients with retinal tears or holes, including rhegmatogenous retinal detachment, who were treated primarily with laser retinopexy. Material and methods: The effect and results of the therapy of patients with one or more retinal tears who underwent therapy with the green laser IQ 532 IRIDEX between December 2019 and August 2022 at our center with a follow-up observation period of at least 3 months were retrospectively evaluated. Results: A total of 14 eyes of 14 patients were treated by this method during the monitored period. All the tears

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Ragiń, Tomasz, Jakub Markiewicz, Krzysztof Markowski, et al. "Fabrication and Properties of Erbium-Doped Gallo-Germanate Glass Thin Films via RF-Sputtering." Photonics Letters of Poland 17, no. 1 (2025): 1–3. https://doi.org/10.4302/plp.v17i1.1310.

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This paper presents novel research on amorphous thin films doped with Er3+ ions deposited using the RF-sputtering method. The obtained layers' surface morphology, chemical composition, and optical properties were examined. Scanning electron microscopy analysis revealed a homogeneous layer structure with thicknesses ranging from 160185 nm. Energy-dispersive spectroscopy confirmed the presence of elements such as Ge, Ba, and Ga. Optical properties were measured using photoluminescence spectroscopy, showing emission in the range of 15201550 nm, indicating potential for the integrated optics emi

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Sousa, Gabriela Giannini de, Catarina Mattoso Mocelin, Eduardo Soares Brollo, and Leila Cristina Soares. "REPENSANDO A LEI DE ESTUPRO DE VULNERÁVEL ATRAVÉS DA EVOLUÇÃO DA SEXARCA CONSENTIDA AO LONGO DO TEMPO." Revista Contemporânea 5, no. 4 (2025): e8003. https://doi.org/10.56083/rcv5n4-095.

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O Código Penal do Brasil considera menores de 14 anos como vulneráveis vítimas de estupro, independentemente do consentimento ao ato, entretanto, a prevalência de início de relação sexual precoce varia amplamente em todo o mundo. O objetivo deste estudo foi analisar a prevalência de relatos de relações sexuais consentidas em idades que, pela legislação, são classificadas como estupro de vulnerável, além de examinar essa prevalência por coortes de nascimento, identificando possíveis mudanças de padrão de sexarca ao longo do tempo. Foram analisados, retrospectivamente, relatos em prontuários do

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Talib, Irsa, Muzammil Yasin, Jawad Hussain, and Raphael Uwamahoro. "Performance Evaluation and Parametric Optimization of Coal-Fired Water Tube Boiler Using the Grey-Taguchi Method." International Journal of Energy Research 2023 (September 13, 2023): 1–11. http://dx.doi.org/10.1155/2023/4203176.

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Industries, district heating companies, and public institutions that use boilers for heating, processing, or power production find it challenging to run at peak efficiencies due to rising fuel prices. Insufficient heat energy production and distribution through boilers contribute to an overall increase in energy expenditure. The performance of a boiler is affected by various controlling parameters, including specific fuel consumption capacity, load, and heat losses. The current study was conducted to evaluate the performance of the coal-fired water tube boiler at D.G. Khan Cement Company Limit

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Browne, Iseult, Ronan McLaughlin, Catherine Weadick, et al. "Abstract PO5-02-04: Irish National Analysis of the Clinical and Economic impact of 21-gene Oncotype DX® testing in Early-Stage, 1-3 lymph node positive, Hormone Receptor positive (HR+), HER2-Negative (HER2-), Breast Cancer (BC)." Cancer Research 84, no. 9_Supplement (2024): PO5–02–04—PO5–02–04. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-02-04.

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Abstract Background: The treatment landscape of HR+ BC is evolving, with a reduction in chemotherapy (CT) use because of Oncotype DX Recurrence Score® testing. Results from the RxPONDER trial suggest that adjuvant CT may benefit some premenopausal women with HR+, HER2- disease with 1-3 positive LN (N1), and a Recurrence Score® (RS) result of ≤25. Postmenopausal women with similar characteristics did not benefit from adjuvant CT. A previous analysis of the impact of Oncotype DX® testing in a N1 BC population from 2 Irish cancer centres identified a 55% reduction in CT use with savings of over €

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De Souza Moura, Jersilene. "Princípio Arm’s Length e a Praticabilidade Tributária." Revista de Direito Tributário Internacional Atual, no. 12 (January 16, 2024): 89–110. http://dx.doi.org/10.46801/2595-7155.12.4.2023.2442.

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O presente trabalho analisa o princípio arm’s length, que sustenta e fundamenta todo o novo arcabouço jurídico dos preços de transferência implementado, no Brasil, pela Lei n. 14.596, de 14 de junho de 2023, em consonância com o padrão internacional de preços de transferência, apresentando posições doutrinárias sob sua aplicabilidade prática para, na sequência, apresentar aspectos relacionados à praticabilidade tributária, diante da nova legislação. Visando ter uma referência sobre a experiência internacional, o presente artigo apresenta também um comparativo sobre o princípio arm’s length no

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Lousada Pinha, Mariana, and Thales Oliveira do Nascimento. "AS RELAÇÕES ENTRE A LEI GERAL DE PROTEÇÃO DE DADOS PESSOAIS E A ARQUIVOLOGIA." Archeion Online 12, no. 2 (2024): 95–112. https://doi.org/10.22478/ufpb.2318-6186.2024v12n2.70630.

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A Lei nº 13.709, de 14 de agosto de 2018, intitulada Lei Geral de Proteção de Dados Pessoais (LGPD) é um normativo recente no Brasil e representa uma resposta às crescentes preocupações com a privacidade e segurança de dados pessoais impactando diretamente a forma como a sociedade e as organizações lidam com as informações de caráter pessoal. Partindo do pressuposto de que parte dessas informações estão registradas em documentos de arquivo é fundamental compreender quais são as possíveis relações entre a LGPD e a Arquivologia. No âmbito desta pesquisa esta análise será realizada por meio da pr

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Balázs, Péter. "Hálapénz után a magyar egészségügyben." Orvosi Hetilap 164, no. 14 (2023): 523–32. http://dx.doi.org/10.1556/650.2023.32722.

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A 2020. évi C. törvény az egészségügyi szolgálati jogviszonyról a Büntető törvénykönyvet módosítva tiltja az egészségügyi szolgáltatásért adott jogtalan előnyt vagy annak ígéretét. Másfelől az Egészségügyi törvény kiegészült az ellátás során elfogadható juttatásokra vonatkozó szabályokkal. Az orvosi közélet és a betegek a változásokat a hálapénz eltiltásaként fogadták. A hálapénz lényegében eltűnt, de az utóhatásaitól nehezebb lesz megszabadulni. A viszonyok rendezéséhez először tisztázni kell a szakdolgozók és a háziorvosok kvázihálapénzét, majd a szakorvosi paraszolvenciát (hálapénzt), amely

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Leite Gomes, Maria de Fátima, Ítalo Oliveira de Paula, Matheus Ramos Araújo de Sousa, and Thereza Helena Paulino de Pontes Borges. "EDUCAÇÃO DE JOVENS E ADULTOS (EJA) NO SISTEMA PRISIONAL:." Direitos Humanos e Transdisciplinaridade 2, no. 2 (2024): 151–69. https://doi.org/10.22478/ufpb.1887-8214.2024v2n2.71422.

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O trabalho em questão, fruto da Pesquisa de Iniciação Científica (PIBIC/UFPB/CNPq), investiga o Sistema Prisional da Paraíba com foco na EJA entre 2023-2024, através do Plano Estadual de Educação para Pessoas Privadas de Liberdade e Egressas do Sistema Prisional/PB, quadriênio 2021-2024. Destaca-se pela discussão se o Estado está garantindo o direito à educação para pessoas privadas de liberdade. Fundamenta-se no Materialismo históricodialético e na Pesquisa Bibliográfica e Documental como procedimentos metodológicos. Têm como resultados preliminares a expansão da EJA por unidade prisional nas

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Ren, Jun, Zohreh Amoozgar, Yuhui Zhao, et al. "Abstract 2343: Targeting EPHB2/ABL1 restores anti-tumor immunity in a preclinical model of ependymoma." Cancer Research 83, no. 7_Supplement (2023): 2343. http://dx.doi.org/10.1158/1538-7445.am2023-2343.

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Abstract Ependymoma is a common type of brain tumor in children, often resistant to available cytotoxics. Molecular profiling studies have led to a better understanding of ependymoma pathology and revealed a critical role of EPHB2. However, the immune system's role in tumor progression and treatment response remains poorly understood. Here, we show that the multikinase inhibitor dasatinib potently inhibits EPHB2 and ABL1 and the growth of ependymoma both in vitro and in vivo. Using an immunocompetent mouse model of ependymoma that faithfully recapitulates its immune microenvironment, we found

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Bernardoni, Vera, Luca Ferrero, Ezio Bolzacchini, et al. "Determination of Aethalometer multiple-scattering enhancement parameters and impact on source apportionment during the winter 2017/18 EMEP/ACTRIS/COLOSSAL campaign in Milan." Atmospheric Measurement Techniques 14, no. 4 (2021): 2919–40. http://dx.doi.org/10.5194/amt-14-2919-2021.

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Abstract. In the frame of the EMEP/ACTRIS/COLOSSAL campaign in Milan during winter 2018, equivalent black carbon measurements using the Aethalometer 31 (AE31), the Aethalometer 33 (AE33), and a Multi-Angle Absorption Photometer (MAAP) were carried out together with levoglucosan analyses on 12 h resolved PM2.5 samples collected in parallel. From AE31 and AE33 data, the loading-corrected aerosol attenuation coefficients (bATN) were calculated at seven wavelengths (λ, where λ values are 370, 470, 520, 590, 660, 880, and 950 nm). The aerosol absorption coefficient at 637 nm (babs_MAAP) was determi

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Lo Gullo, A., A. Becciolini, S. Parisi, et al. "AB1101 THERAPEUTIC EFFECTS OF APREMILAST ON ENTHESITIS AND DACTYLITIS IN REAL CLINICAL SETTING: AN ITALIAN MULTICENTER STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1777–78. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2779.

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BackgroundTo date only few real-world setting studies evaluated apremilast efficacy in psoriatic arthritis (PsA). Enthesitis and dactylitis are difficult-to-treat features of PsA leading to disability and affecting quality of life.ObjectivesThe aims of this study is to evaluate the leed enthesitis index (LEI) and dactlitis index (DAI) at 6 and 12 month in patients on treatment with apremilast.MethodsAll PsA consecutive patients treated with apremilast in fifteen Italian rheumatological referral centers were enrolled. Anamnestic data, treatment history, and PsA disease activity (DAPSA), LEI, DA

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Scriffignano, S., F. M. Perrotta, M. Fatica, et al. "AB1135 CHARACTERIZING THE MINIMAL DISEASE ACTIVITY DOMAINS ACHIEVED BASED ON DIFFERENT TREATMENTS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1798.1–1798. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2071.

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BackgroundMinimal Disease Activity (MDA) is a validated treatment response index for Psoriatic Arthritis (PsA). A status of MDA is reached when 5/7 domains are achieved. Even if MDA is worldwide used, both in clinical trials and in clinical practice, nowadays there are no studies that evaluated any differences in the MDA domains achievement based on various treatments.ObjectivesTo characterize the MDA domains achieved based on treatment; to assess which treatment is associated with a higher probability to reach MDA status in clinical practice.MethodsThis is a cross sectional analysis of two lo

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Capicchioni, Amos. "L’erroneo ricorso al trust quale adempimento di un debito scaduto nei confronti del trustee (App. Palermo, 14 luglio 2023)." N° 1 (gennaio-febbraio), no. 5 (February 1, 2024): 42–46. http://dx.doi.org/10.35948/1590-5586/2024.475.

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Massima È revocabile ex art. 2901 cod. civ. il conferimento di un immobile in trust (con beneficiari i figli della disponente e trustee la di lei madre) posto in essere dalla disponente successivamente alla affermazione in riconvenzionale (nel giudizio di opposizione all’esecuzione promosso dalla disponente) di un credito da parte del creditore agente in revocatoria: l’eventus damni sussiste per avere la disponente conferito in trust l’unico immobile di cui è titolare, mentre la scientia damni, requisito soggettivo richiesto in considerazione della natura gratuita del trust, si desume dalla da

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Adiansyah, Muhammad, Endang Mahati, Farmaditya Mundhofir, Nani Maharani, Yora Nindita, and Hermawan Istiadi. "Effect of piper Crocatum leaves extract on atherosclerosis in diabetic rats." Journal of Advanced Biotechnology and Experimental Therapeutics 6, no. 1 (2023): 254. http://dx.doi.org/10.5455/jabet.2023.d123.

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Atherosclerosis is caused by an inflammatory process in the endothelium due to an imbalance between oxidant and antioxidant agents that often occurs in Diabetes mellitus (DM) patients. Antioxidants that function to neutralize superoxide can be used to prevent atherosclerosis in DM. Piper crocatum leaves shows an unknown antioxidant effect on the atherosclerosis process.The aim of this study is to determine the effect Piper crocatum leaves extract on blood MDA levels and the severity of atherosclerosis in diabetic rats. 30 Sprague Dawley rats were randomly divided into 6 groups, namely, HC (non

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Balandin, D. V., and D. I. Fedorova. "Application of Public-Private Partnership Mechanisms to Ensure Innovative Development of the Healthcare Sector." Regulatory Research and Medicine Evaluation 14, no. 5 (2024): 521–32. http://dx.doi.org/10.30895/1991-2919-2024-14-5-521-532.

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INTRODUCTION. The pursuit of technological sovereignty in the current geopolitical situation has led to a growing emphasis on studying relations in the field of government support for healthcare innovation, in particular, the institute of public–private partnership (PPP). In the face of the challenges presented by sanctions, the economic crisis, and a potential deficit in sustainably competitive national innovative medical products, the Russian government is confronted with the necessity of financing the development and production of innovative medical products, including through involving pri

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Liu, Wenbin, Zhengwei Tan, Yuechao Zhao, Huijin Hu, Dijiong Wu, and Baodong Ye. "New Aplastic Anemia Preconditioned with Fludarabine, Thiotepa, Cyclophosphamide, and Anti-Thymocyte Globulin." Blood 142, Supplement 1 (2023): 2160. http://dx.doi.org/10.1182/blood-2023-179680.

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Aplastic anemia (AA) is one of life-threatening hematological disorder that can be cured by hematopoietic stem cell transplantation. When the absence of a matched sibling donor, haploidentical stem cell transplantation (haplo-HSCT) becomes an alternative choice for AA patients. We used a prospective study aimed to confirm the feasibility of Thiotepa-based modified post-transplantation cyclophosphamide (PTCY) strategy in haplo-HSCT for AA patients. We analyzed the outcomes of 15 patients who had undergone haplo-HSCT between October 2021-May 2023 in our clinical center. The modified condition re

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Michell de Araujo Silva, Alessandro, and Filipe Ezequiel da Silva. "Identificação de Áreas de Risco de Inundação no Baixo Açu, Semiárido Brasileiro, através de Imagens Multiespectrais e SAR." Revista Brasileira de Geografia Física 17, no. 6 (2024): 4502–29. http://dx.doi.org/10.26848/rbgf.v17.6.p4502-4529.

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Este trabalho objetivou reconhecer o alcance e os impactos das inundações no baixo curso do Rio Açu, Semiárido Brasileiro, através de imagens óticas multiespectrais Landsat 5 TM e 7ETM, imagens de radar de abertura sintética PALSAR-1, bem como imagens de alta resolução da plataforma Google Earth. Pode-se reconhecer que as áreas susceptíveis à inundação perfazemao menos 532 km², afetando todos os 9 municípios da região, onde foram identificadas 4732 edificações em situação de risco até o ano de 2019, número 14% maior do que o observado no ano de 2010. Cerca de 70% das edificações em risco ocorr

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Ozhathil, Deepak, Carter Powell, Joshua Rivers, Henry Ross, Steven Kahn, and John Bailey. "523 A Survey of Skin Substitute Use Among Burn Surgeons Across the Country." Journal of Burn Care & Research 46, Supplement_1 (2025): S119. https://doi.org/10.1093/jbcr/iraf019.152.

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Abstract Introduction A plethora of “skin substitutes” exist in burn care with limited comparative analysis trials in the literature. This presents a unique challenge to providers seeking to optimize product selection. We sought to perform a cross-sectional survey of practicing burn surgeons to explore what products being utilized and identify the indications for use. Methods A 14-question survey was distributed to burn surgeons across the country who attended academic meetings. Contributors were actively practicing burn surgeons and identified the skin substitutes they routinely use in practi

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Barendrecht, Maarten, Carl C. Barten, Willem van Mechelen, Evert Verhagen, and Bouwien C. M. Smits-Engelsman. "Injuries in Physical Education Teacher Students: Differences between Sex, Curriculum Year, Setting, and Sports." Translational Sports Medicine 2023 (January 5, 2023): 1–11. http://dx.doi.org/10.1155/2023/8643402.

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Background. Injury risk is high in Physical Education Teacher Education (PETE) students. Insights into specific injury locations per sex, setting, sports, and curriculum year are needed to develop preventive measures. Purpose. To compare injury distributions by body locations in PETE students and how these distributions differ by sex, type, onset, curriculum year, settings, or sports. Methods. In a historical cohort study over 14 years, data from 2899 students (male 76.2%, n = 1947) enlisted in the first three years of a PETE curriculum were analysed. Injuries reported at the institution’s med

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Kur`yato, Nikolay, Larisa Knyazeva, Andrey Dorokhov, and Viktoriya Bryksina. "ANTI-CORROSION PROTECTION OF COPPER WITH OILS COMPOSITIONS CONTAINING ADDITIVE M-531." SCIENCE IN THE CENTRAL RUSSIA, no. 2 (April 27, 2024): 86–97. http://dx.doi.org/10.35887/2305-2538-2024-2-86-97.

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The use of anti-corrosion protection is necessary to maintain the performance of agricultural machinery and equipment. The effectiveness of oil compositions with the addition of M-531 in relation to copper was studied. The compositions were obtained on the basis of industrial and motor M10G2k (both fresh and used) oils. Their protective ability was studied using gravimetric and electrochemical methods (polarization and impedance) studies. According to the data obtained from corrosion gravimetric tests in 0.5 M NaCl, it was noted that compositions based on M10G2k oil turned out to be the most e

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Cooke, Rosalyn, Alison Rushton, James Martin, Andy Soundy, Lee Herrington, and Nicola R. Heneghan. "Lower extremity functional performance tests and their measurement properties in athletes: a systematic review and narrative synthesis." BMJ Open Sport & Exercise Medicine 11, no. 2 (2025): e002389. https://doi.org/10.1136/bmjsem-2024-002389.

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ObjectiveTo identify functional performance tests (FPTs) with potential to identify athletes at risk of lower extremity injury (LEI) and assess their measurement properties.DesignSystematic review conducted in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses and PRISMA in Exercise, Rehabilitation, Sports Medicine and Sports Science guidance.Data sourcesTwo-stage systematic search of Medline, Embase, Cumulative Index to Nursing and Allied Health Literature and SPORTDiscus databases from inception to 24 November 2023, supplemented by hand searching of reference lists,

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Desai, Jayesh, Sae-Won Han, Jong-Seok Lee, et al. "Abstract CT029: Phase Ib study of GDC-6036 in combination with cetuximab in patients with colorectal cancer (CRC) with KRAS G12C mutation." Cancer Research 83, no. 8_Supplement (2023): CT029. http://dx.doi.org/10.1158/1538-7445.am2023-ct029.

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Abstract Background: GDC-6036 is an oral, highly potent and selective KRAS G12C inhibitor that demonstrated anti-tumor activity in patients with KRAS G12C-positive advanced solid tumors, including CRC. In a previously reported single-agent cohort, GDC-6036 achieved a best response of partial response or complete response in 35% (19/55) of patients, with a confirmed overall response rate (ORR) of 24% (13/55 patients) in KRAS G12C-positive CRC patients (Desai et. al., ESMO 2022). EGFR blockade may sensitize tumors to KRAS G12C inhibition and the combination of an anti-EGFR antibody (cetuximab) w

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Cruz Correa, O., D. Ganatra, A. Garrido, et al. "POS1608 MIRNA BIOMARKERS FOR ARTICULAR AND CUTANEOUS RESPONSE TO METHOTREXATE IN PSORIATIC ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1149. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2664.

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BackgroundPsoriatic arthritis (PsA) is a chronic, progressive disease associated with psoriasis that can lead to joint damage, disability, and increased mortality. Early diagnosis and management of inflammation is essential for improving clinical outcomes. Methotrexate (MTX) is the recommended first-line treatment for early PsA patients with polyarthritis and relevant skin involvement, however many patients are unresponsive to therapy. MicroRNA (miRNA) modulate gene expression at a post-transcriptional level and constitute a promising source of biomarkers that could enable the future personali

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Sass, Jaydey, and Elbie Adendorff. "Teoretiese begronding vir die ontwerp van ’n uitspraaktoepassingsmodel gemik op vreemdetaalsprekers van Afrikaans (deel 2 van ’n drieluik)." LitNet Akademies 20, no. 2 (2023): 353–404. http://dx.doi.org/10.56273/1995-5928/2023/j20n2d2.

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Opsomming Hierdie artikel is die tweede van drie wat verslag lewer oor ’n navorsingstudie wat deur die eerste skrywer vir ’n doktorale studie1 onderneem is. Die eerste artikel verskaf die navorsingsontwerp vir die studie. Dié artikel behels die uiteensetting van die teoretiese begronding van ’n gespelifieerde uitspraaktoepassingsmodel vir Engelssprekende studente2 wat Afrikaans as ’n vreemde taal3 aanleer.4 In die laaste artikel plaas ons die fokus op die model waarop ’n gespelifieerde uitspraaktoepassing ontwerp kan word. Nieluistervriendelike uitspraak5 kan verwarring in gesprekke veroorsaak

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La, Ting, Song Chen, Xiao Hong Zhao, et al. "Abstract 3798: lncRNA LIMp27 promotes p53-defective cancer pathogenesis." Cancer Research 83, no. 7_Supplement (2023): 3798. http://dx.doi.org/10.1158/1538-7445.am2023-3798.

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Abstract Inactivation of p53 occurs in approximately 50% of human cancers, where p53-mediated p21 activation is devoid and p27 becomes essential for the establishment of the G1/S checkpoint upon DNA damage. Here, we show that the E2F1-responsive lncRNA LIMp27 selectively represses p27 expression and promotes proliferation, tumorigenicity, and treatment resistance in p53-defective colon adenocarcinoma (COAD) cells. LIMp27 competes with p27 mRNA for binding to cytoplasmically localized hnRNA0, which otherwise stabilizes p27 mRNA, leading to cell cycle arrest at the G0/G1 phase. In response to DN

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Van Dijk, B., N. Den Hollander, M. Reijnierse, and A. Van der Helm – van Mil. "OP0170 INTEROSSEOUS TENDON INFLAMMATION ACROSS THE EARLY ARTHRITIS SPECTRUM: A 10-YEAR MRI-STUDY INVESTIGATING ITS PREVALENCE AT DIAGNOSIS AND RELATION WITH CLINICAL SIGNS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 113.1–113. http://dx.doi.org/10.1136/annrheumdis-2023-eular.550.

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BackgroundInflammation around the tendons of the hand interosseous muscles (interosseous tendon inflammation; ITI) was recently identified on MRI in a set of RA and arthralgia patients.ObjectivesHowever, the prevalence of ITI at diagnosis of RA is unknown, as is its prevalence in other arthritides and its relationship with clinical signs. These questions prompted us to perform this large MRI study.Methods1,205 consecutive patients presenting with early arthritis between 2010-2020 underwent contrast-enhanced hand MRI. MRIs were evaluated, blind to clinical data, for ITI lateral of MCP2-5 and fo

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Lee, Sohyon, Tobias Weiss, Marcel Bühler, et al. "Abstract 5325: Image-based functional precision medicine for repurposing neuroactive drugs in glioblastoma." Cancer Research 82, no. 12_Supplement (2022): 5325. http://dx.doi.org/10.1158/1538-7445.am2022-5325.

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Abstract Treatment of glioblastoma multiforme (GBM), the most aggressive form of primary brain cancer, has essentially not advanced over the past few decades. Numerous challenges hinder the successful development of new therapies, including drug delivery across the blood-brain barrier (BBB), the complexity of the tumor microenvironment (TME), and the lack of clinically predictive cancer models. Here, we present the results of an image-based ex vivo drug-testing platform that addresses these therapeutic roadblocks. To demonstrate the clinical utility of our platform, in a retrospective cohort o

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Arestova, N. N., L. A. Katargina, E. V. Denisova, T. B. Kruglova, and N. S. Egiyan. "Laser Iridotomy for Pupillary Block in Children with Endogenous Uveitis." Ophthalmology in Russia 20, no. 1 (2023): 69–75. http://dx.doi.org/10.18008/1816-5095-2023-1-69-75.

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Objective. Development of a differential approach to laser iridotomy in children with endogenous uveitis considering iris characteristics and the reaction of children’s eyes to different laser types.Patients and methods. Thirty-six laser iridotomies were conducted in 36 children aged 8–16 years with pupillary block. Nidek YAG laser was used in YAG (1064 nm) and SLT (532 nm) modes.Results. The frequency of hemorrhagic complications during surgery decreased to 19.4 % since 2009. The frequency of exudative reactions and proliferative syndrome with closure of laser coloboms in 1-6 months after sur

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Permatasari, Dhita, Tomoliyus Tomoliyus, Awan Hariono, and Trisnar Adi Prabowo. "Effect of Weight Training on Increasing 100 Meter Running Speed in Sprinter Athletes Based on Gender." Journal of Advances in Sports and Physical Education 7, no. 01 (2024): 1–6. http://dx.doi.org/10.36348/jaspe.2024.v07i01.001.

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The aim of this study was to investigate the effect of weight training on the performance of 100meter spinner athletes based on gender. This research is one group pretest – posttest. Samples on athletes were carried out voluntarily provided that they were not injured and were not taking part in a competition period. The sample consisted of 10 male sprinters (mean: height 170.2±0.6 cm, weight 64.2±2.7, body mass index (BMI) 21.27, training experience 5.6±7.8 years) and 10 female sprinters (mean: height 168.7±7.2, weight 53.7±0.6, body mass index (BMI) 18.14, training experience 5.2±14 years) wi

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Venancio de Souza Santos Filho, Fábio. "“THEY TRIED TO MAKE ME GO TO REHAB, BUT I SAID NO”:." Direitos Humanos e Transdisciplinaridade 2, no. 2 (2024): 131–50. https://doi.org/10.22478/ufpb.1887-8214.2024v2n2.71415.

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Considerando as relações materialistas e históricas que moldam as conjunturas sócio-políticas e epistemológicas, partindo do contexto europeu, passando pelo brasileiro até desaguar no cenário paraibano, este artigo tem como objetivo difundir as incoerências jurídicas que possibilitam a perpetuação das Comunidades Terapêuticas. Por meio da análise de conteúdo de materiais bibliográficos disponíveis no Google Acadêmico e na Scielo Brasil, das normas brasileiras que dispõem sobre a garantia do cuidado da saúde mental em liberdade e as denúncias e investigações sobre as Comunidades Terapêuticas pa

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Andreasen, Julia R., Anna E. Hogg, and Heather L. Selley. "Change in Antarctic ice shelf area from 2009 to 2019." Cryosphere 17, no. 5 (2023): 2059–72. http://dx.doi.org/10.5194/tc-17-2059-2023.

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Abstract. Antarctic ice shelves provide buttressing support to the ice sheet, stabilising the flow of grounded ice and its contribution to global sea levels. Over the past 50 years, satellite observations have shown ice shelves collapse, thin, and retreat; however, there are few measurements of the Antarctic-wide change in ice shelf area. Here, we use MODIS (Moderate Resolution Imaging Spectroradiometer) satellite data to measure the change in ice shelf calving front position and area on 34 ice shelves in Antarctica from 2009 to 2019. Over the last decade, a reduction in the area on the Antarc

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He, Fang, Rufeng Zhang, Mari Kuraguchi, Lei Zhao, and Zhaoxue Yu. "Abstract 3993: In vivo efficacy of an anti-human IL11RA antibody in B-hIL11RA mice with APAP-induced liver damage." Cancer Research 83, no. 7_Supplement (2023): 3993. http://dx.doi.org/10.1158/1538-7445.am2023-3993.

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Abstract Acetaminophen (N-acetyl-p-aminophenol; APAP) overdose is a common cause of drug-induced acute liver injury, thereby making APAP administration a frequently used experimental model due to its highly reproducible and dose-dependent hepatoxicity. APAP-induced liver injury (AILI) mouse models exhibited upregulated IL11 expression, indicating that targeting IL11 or its cognate receptor, IL11RA, could have therapeutic potential. To evaluate the in vivo efficacy of anti-human IL11RA antibodies in AILI mouse models, we first generated a human IL11RA knock-in mouse model (B-hIL11RA), in which

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Zhao, Lei, Chengzhang Shang, Rebecca Soto, Chonghui Liu, and Zhaoxue Yu. "Abstract 4592: In vivo efficacy evaluation of anti-human VEGFR2 antibodies in humanized B-hVEGFR2 mice." Cancer Research 83, no. 7_Supplement (2023): 4592. http://dx.doi.org/10.1158/1538-7445.am2023-4592.

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Abstract Angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis is partly regulated by VEGF binding to VEGFR2, which forms receptor dimers and activates downstream signaling pathways. In addition to developmental cues, VEGFR2 is also associated with disease progression for psoriasis, rheumatoid arthritis, diabetic retinopathy, and more significantly, tumor growth and drug resistance. Given this, inhibition of VEGFR2 signaling is actively being studied, and multiple VEGFR2 inhibitors have entered various phases of clinical studies and have shown promising results

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Shah, Akansha M., Lei Guo, Maria Gabriella Morales, et al. "Abstract 4750: TWIST2 mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma." Cancer Research 83, no. 7_Supplement (2023): 4750. http://dx.doi.org/10.1158/1538-7445.am2023-4750.

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Abstract Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children that resembles the developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate despite expression of the myogenic determination protein MYOD. The TWIST2 transcription factor is frequently overexpressed in fusion-negative RMS (FN-RMS). TWIST2 blocks differentiation by inhibiting MYOD activity in myoblasts, but its role in FN-RMS pathogenesis is incompletely understood. Here, we show that knockdown of TWIST2 enables FN-RMS cells to exit the cell cycle and undergo terminal myogenesis. TWIST2 kn

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Ryu, Han Suk, Soo Young Park, Da Sol Kim, and Cheng Hyun Lee. "Abstract 5312: Next generation quantitative proteomic analysis of urothelial lesions reveals novel diagnostic biomarkers to distinguish pathologic pitfalls and protein-protein interactions." Cancer Research 83, no. 7_Supplement (2023): 5312. http://dx.doi.org/10.1158/1538-7445.am2023-5312.

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Abstract There are several unmet needs remained to be solved in bladder urothelial lesions. Especially, the molecular biology of inverted urothelial papilloma (IUP) as a precursor disease of urothelial carcinoma is poorly understood. Also, muscle-invasive urothelial carcinoma (MIUC) of the bladder, showing a highly aggressive tumor behavior, has prompted the quest for robust biomarkers associated with invasion. A total of 265 tissue specimens from urinary bladder were enrolled for proteomic analysis and validation. Candidate biomarkers were selected through bioinformatic analysis, followed by

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Kim, Beom-Jun, Ze-Yi Zheng, Jonathan Lei, et al. "Abstract PO2-14-11: Proteogenomic approaches for the identification of NF1/neurofibromin-depleted estrogen receptor positive breast cancers for targeted treatment." Cancer Research 84, no. 9_Supplement (2024): PO2–14–11—PO2–14–11. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-14-11.

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Abstract NF1 is a key tumor suppressor that represses both RAS and estrogen receptor-α (ER) signaling in breast cancer. Blocking both pathways by fulvestrant (F), a selective ER degrader (SERD), together with binimetinib (B), a MEK inhibitor, promotes tumor regression in NF1-depleted ER+ models. We aimed to establish approaches to determine how NF1 protein levels impact B+F treatment response to improve our ability to identify B+F sensitive tumors. We examined a panel of ER+ PDX models by DNA and mRNA sequencing and found that more than half of these models carried an NF1 shallow deletion and

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Bernatskyi, Artemii, Volodymyr Lukashenko, Oleksandr Siora, and Mykola Sokolovskyi. "Analysis of the application of lasers for counter-UAV purposes." History of science and technology 14, no. 2 (2024): 487–512. https://doi.org/10.32703/2415-7422-2024-14-2-487-512.

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From the dawn of human history, mankind has always made efforts to create more effective tools for combating other creatures, including fellow people. Thus, the utilisation of different species of animals, the creation of new weapons and other means of human progress have always led to new developments, aimed at emulating, replacing or combating these innovations. The development of unmanned aerial vehicles has prompted the need to develop alternative and innovative countermeasures. These methods may range from the usage of interceptor drones to the application of concentrated energy beams. Th

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