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Journal articles on the topic 'Leishmanicidal'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Delorenzi, Jan Carlo, Leonardo Freire-de-Lima, Cerli R. Gattass, et al. "In Vitro Activities of Iboga Alkaloid Congeners Coronaridine and 18-Methoxycoronaridine against Leishmania amazonensis." Antimicrobial Agents and Chemotherapy 46, no. 7 (2002): 2111–15. http://dx.doi.org/10.1128/aac.46.7.2111-2115.2002.

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ABSTRACT In previous studies, we demonstrated the leishmanicide effect of coronaridine, a natural indole alkaloid isolated from stem bark of Peschiera australis (Delorenzi et al., Antimicrob. Agents Chemother. 45:1349-1354, 2001). In this study we show the leishmanicidal effect of the synthetic coronaridine and its racemic 18-methoxylated analog, 18-methoxycoronaridine. Both alkaloids revealed a potent leishmanicide effect against Leishmania amazonensis, a causative agent of cutaneous and diffuse cutaneous leishmaniasis in the New World. Despite their potent leishmanicide effect, both alkaloid

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2

Santos, Anderson Rouge dos, Camila Alves Bandeira Falcão, Michelle Frazão Muzitano, Carlos Roland Kaiser, Bartira Rossi-Bergmann, and Jean-Pierre Férézou. "Ivermectin-derived leishmanicidal compounds." Bioorganic & Medicinal Chemistry 17, no. 2 (2009): 496–502. http://dx.doi.org/10.1016/j.bmc.2008.12.003.

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3

Gatti, R. M., O. Augusto, J. K. Kwee, and S. Giorgio. "Leishmanicidal activity of peroxynitrite." Redox Report 1, no. 4 (1995): 261–65. http://dx.doi.org/10.1080/13510002.1995.11746996.

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4

Correa, Edwin, Diana Cardona, Winston Quiñones, et al. "Leishmanicidal activity ofPycnoporus sanguineus." Phytotherapy Research 20, no. 6 (2006): 497–99. http://dx.doi.org/10.1002/ptr.1890.

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5

Begum, Sabira, Anjum Ayub, Syeda Qamar Zehra, Bina Shaheen Siddiqui, M. Iqbal Choudhary, and Samreen. "Leishmanicidal Triterpenes fromLantana camara." Chemistry & Biodiversity 11, no. 5 (2014): 709–18. http://dx.doi.org/10.1002/cbdv.201300151.

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6

Antonello, Ana Maria, Thaís Sartori, Ana Paula Folmer Correa, et al. "Entomopathogenic bacteriaPhotorhabdus luminescensas drug source againstLeishmania amazonensis." Parasitology 145, no. 8 (2017): 1065–74. http://dx.doi.org/10.1017/s0031182017002001.

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AbstractLeishmaniasis is a widely spread and zoonotic disease with serious problems as low effectiveness of drugs, emergence of parasite resistance and severe adverse reactions. In recent years, considerable attention has been given to secondary metabolites produced byPhotorhabdus luminescens, an entomopathogenic bacterium. Here, we assessed the leishmanicidal activity ofP. luminescensculture fluids. Initially, promastigotes ofLeishmania amazonensiswere incubated with cell free conditioned medium ofP. luminescensand parasite survival was monitored. Different pre-treatments of the conditioned m

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7

Baccarini, M., S. Hockertz, A. F. Kiderlen, and M. L. Lohmann-Matthes. "Extracellular killing of Leishmania promastigotes and amastigotes by macrophage precursors derived from bone marrow cultures." Journal of Experimental Medicine 167, no. 4 (1988): 1486–92. http://dx.doi.org/10.1084/jem.167.4.1486.

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Flagellates of the genus Leishmania are obligate intracellular parasites of vertebrates including man. The microorganisms reside and multiply inside the phagolysosomes of cells of the mononuclear phagocyte lineage. We here report on the spontaneous leishmanicidal activity exerted extracellularly by immature cells of the mononuclear phagocyte lineage. Highly purified, bone marrow-derived macrophage precursor cells displayed a strong spontaneous leishmanicidal activity already at very low effector/target rations (3:1, 6:1). This leishmanicidal activity was effective against both promastigotes an

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8

Marques, Estela Mesquita, Lucas George Santos Santos Andrade, Luciana Magalhães Rebelo Rebelo Alencar, et al. "Nanotechnological Formulation Incorporating Pectis brevipedunculata (Asteraceae) Essential Oil: An Ecofriendly Approach for Leishmanicidal and Anti-Inflammatory Therapy." Polymers 17, no. 3 (2025): 379. https://doi.org/10.3390/polym17030379.

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Cutaneous leishmaniasis caused by Leishmania amazonensis is a significant public health issue. This study aimed to evaluate an ecofriendly, thermosensitive nanogel, developed using a low-energy, solvent-free method, incorporating F127 and Carbopol 974P copolymers, and enriched with Pectis brevipedunculata essential oil (EOPb) for its leishmanicidal and anti-inflammatory properties. The nanogel was prepared and characterized through FTIR, DLS, SEM, and AFM to confirm the incorporation of EOPb as well as its stability and rheological properties. In vitro leishmanicidal activity was evaluated on

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9

Bringmann, Gerhard, Katja Thomale, Sebastian Bischof, et al. "A Novel Leishmania major Amastigote Assay in 96-Well Format for Rapid Drug Screening and Its Use for Discovery and Evaluation of a New Class of Leishmanicidal Quinolinium Salts." Antimicrobial Agents and Chemotherapy 57, no. 7 (2013): 3003–11. http://dx.doi.org/10.1128/aac.02201-12.

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ABSTRACTIn most laboratories, the screening for leishmanicidal compounds is carried out withLeishmaniapromastigotes or axenic amastigotes. However, the best approach to identify leishmanicidal compounds is the use of amastigotes residing in macrophages. Reporter gene-based assays are relatively new tools in the search for drugs against eucaryotic protozoa, permitting the development of faster, more automated assays. In this paper, we report on the establishment of a rapid screening assay in a 96-well format. A luciferase-transgenic (Luc-tg)Leishmania majorstrain was generated and used to infec

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10

Beattie, Lynette, Rebecca Phillips, Najmeeyah Brown, et al. "Interferon Regulatory Factor 7 Contributes to the Control ofLeishmania donovaniin the Mouse Liver." Infection and Immunity 79, no. 3 (2010): 1057–66. http://dx.doi.org/10.1128/iai.00633-10.

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ABSTRACTOptimal hepatic resistance toLeishmania donovaniin mice requires the coordinated effort of a variety of leukocyte populations that together induce activation of local macrophages to a leishmanicidal state. Although nitric oxide and reactive oxygen intermediates are potent leishmanicidal effector molecules operating in the acquired phase of immunity, there have long been suggestions that other mechanisms of leishmanicidal activity exist. We recently discovered thatIrf-7regulates a novel innate leishmanicidal response in resident splenic macrophages that line the marginal zone. Here, we

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11

Chicharro, Cristina, Cesare Granata, Rosario Lozano, David Andreu, and Luis Rivas. "N-Terminal Fatty Acid Substitution Increases the Leishmanicidal Activity of CA(1-7)M(2-9), a Cecropin-Melittin Hybrid Peptide." Antimicrobial Agents and Chemotherapy 45, no. 9 (2001): 2441–49. http://dx.doi.org/10.1128/aac.45.9.2441-2449.2001.

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ABSTRACT In order to improve the leishmanicidal activity of the synthetic cecropin A-melittin hybrid peptide CA(1-7)M(2-9) (KWKLFKKIGAVLKVL-NH2), a systematic study of its acylation with saturated linear fatty acids was carried out. Acylation of the Nɛ-7 lysine residue led to a drastic decrease in leishmanicidal activity, whereas acylation at lysine 1, in either the α or the ɛ NH2 group, increased up to 3 times the activity of the peptide against promastigotes and increased up to 15 times the activity of the peptide against amastigotes. Leishmanicidal activity increased with the length of the

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12

Moreira, Fernanda, Thalita Riul, Marcela Moreira, et al. "Leishmanicidal Effects of Piperlongumine (Piplartine) and Its Putative Metabolites." Planta Medica 84, no. 15 (2018): 1141–48. http://dx.doi.org/10.1055/a-0614-2680.

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AbstractPiperlongumine is an amide alkaloid found in Piperaceae species that shows a broad spectrum of biological properties, including antitumor and antiparasitic activities. Herein, the leishmanicidal effect of piperlongumine and its derivatives produced by a biomimetic model using metalloporphyrins was investigated. The results showed that IC50 values of piperlongumine in promastigote forms of Leishmania infantum and Leishmania amazonensis were 7.9 and 3.3 µM, respectively. The IC50 value of piperlongumine in the intracellular amastigote form of L. amazonensis was 0.4 µM, with a selectivity

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13

Martín-Montes, Álvaro, María Paz Clares, Rubén Martín-Escolano, et al. "Heterocyclic Diamines with Leishmanicidal Activity." ACS Infectious Diseases 7, no. 12 (2021): 3168–81. http://dx.doi.org/10.1021/acsinfecdis.1c00215.

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14

Fernández-Rubio, Celia, Esther Larrea, José Peña Guerrero, et al. "Leishmanicidal Activity of Isoselenocyanate Derivatives." Antimicrobial Agents and Chemotherapy 63, no. 2 (2018): e00904-18. http://dx.doi.org/10.1128/aac.00904-18.

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ABSTRACTConventional chemotherapy against leishmaniasis includes agents exhibiting considerable toxicity. In addition, reports of drug resistance are not uncommon. Thus, safe and effective therapies are urgently needed. Isoselenocyanate compounds have recently been identified with potential antitumor activity. It is well known that some antitumor agents demonstrate effects againstLeishmania. In this study, thein vitroleishmanicidal activities of several organo-selenium and organo-sulfur compounds were tested againstLeishmania majorandLeishmania amazonensisparasites, using promastigotes and int

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15

Kam, Toh-Seok, Kooi-Mow Sim, Takashi Koyano, and Kanki Komiyama. "Leishmanicidal alkaloids from Kopsia griffithii." Phytochemistry 50, no. 1 (1999): 75–79. http://dx.doi.org/10.1016/s0031-9422(98)00492-0.

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16

Choudhary, M. Iqbal, Sammer Yousuf, Samreen, Shakil Ahmed, and Atta-Ur-Rahman. "New leishmanicidal physalins fromPhysalis minima." Natural Product Research 21, no. 10 (2007): 877–83. http://dx.doi.org/10.1080/14786410701315147.

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17

Lezama-Dávila, Claudio M., Angélica P. Isaac-Márquez, Pedro Zamora-Crescencio, et al. "Leishmanicidal activity of Pentalinon andrieuxii." Fitoterapia 78, no. 3 (2007): 255–57. http://dx.doi.org/10.1016/j.fitote.2006.12.005.

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18

Dos Anjos Alvarenga Amante, João Francisco, Amanda Ribeiro Santos, Bárbara Mello Santos, et al. "MARBOFLOXACIN INDUCES LEISHMANICIDAL ACTIVITY AND LESS INFLAMMATORY RESPONSE IN Leishmania chagasi INFECTED MACROPHAGES." Veterinária e Zootecnia 27 (November 24, 2020): 1–11. http://dx.doi.org/10.35172/rvz.2020.v27.510.

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Marbofloxacin has promising leishmanicidal activity due to the direct action on the Leishmania chagasi amastigotes. It was developed only for veterinary medicine uses, and it could be used as an drug for the treatment of Canine Visceral Leishmaniasis (CVL). In the present study, we evaluated the leishmanicidal effect and macrophage modulation of marbofloxacin in macrophages infected with amastigotes of L. chagasi. Macrophages were collected from peritoneum of BALB/c mice and infected with promastigotes of L. chagasi. After internalization and transformation into amastigotes forms, cells were t

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19

Luque-Ortega, Juan Román, Silvia Martínez, José María Saugar, et al. "Fungus-Elicited Metabolites from Plants as an Enriched Source for New Leishmanicidal Agents: Antifungal Phenyl-Phenalenone Phytoalexins from the Banana Plant (Musa acuminata) Target Mitochondria of Leishmania donovani Promastigotes." Antimicrobial Agents and Chemotherapy 48, no. 5 (2004): 1534–40. http://dx.doi.org/10.1128/aac.48.5.1534-1540.2004.

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ABSTRACT Two antifungal phenyl-phenalenone phytoalexins isolated from the banana plant (Musa acuminata) elicited with the fungus Fusarium oxysporum, together with a methoxy derivative of one of them and two epoxide precursors of their chemical synthesis, were tested for leishmanicidal activity on Leishmania donovani promastigotes and L. infantum amastigotes. Drugs inhibited proliferation of both forms of the parasite with a 50% lethal concentration range between 10.3 and 68.7 μg/ml. Their lethal mechanism was found linked to the respiratory chain by a systematic approach, including electron mi

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20

Marín, Clotilde, Mario Inclán, Inmaculada Ramírez-Macías, et al. "In vitro antileishmanial activity of aza-scorpiand macrocycles. Inhibition of the antioxidant enzyme iron superoxide dismutase." RSC Advances 6, no. 21 (2016): 17446–55. http://dx.doi.org/10.1039/c5ra21262f.

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21

Khatami, Mehrdad, Hajar Alijani, Iraj Sharifi, et al. "Leishmanicidal Activity of Biogenic Fe3O4 Nanoparticles." Scientia Pharmaceutica 85, no. 4 (2017): 36. http://dx.doi.org/10.3390/scipharm85040036.

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22

Sánchez Suárez, Jeysson, Julián Pérez Cordero, and Ericsson Coy-Barrera. "Phenolics with Leishmanicidal and Immunomodulatory Properties." Revista Facultad de Ciencias Básicas 10, no. 1 (2014): 102. http://dx.doi.org/10.18359/rfcb.342.

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<p class="Pa29">La leishmanioisis permanece actualmente como un problema de salud pública que ha cobrado gran relevancia, sobre todo en países en vía de desarrollo, en cuya mayoría, la enfermedad es endémica. El incremento de reportes de fallo terapéutico por la aparición de cepas resistentes así como la severidad de los efectos adversos conocidos para los tratamientos actuales, han hecho imperativa la búsqueda de nuevos agentes antileishmaniales. En ésta búsqueda se ha establecido que, adicional al efecto parasitocida, un potencial inmunomodulador podría contribuir significativamente

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23

Riente, R., V. Souza, S. Carvalho, M. Kaiser, R. Brun, and E. da Silva. "Leishmanicidal Activity of New Megazol Derivatives." Medicinal Chemistry 5, no. 4 (2009): 392–97. http://dx.doi.org/10.2174/157340609788681467.

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24

Fernández-Rubio, Celia, Daphne Campbell, Andrés Vacas, et al. "Leishmanicidal Activities of Novel Methylseleno-Imidocarbamates." Antimicrobial Agents and Chemotherapy 59, no. 9 (2015): 5705–13. http://dx.doi.org/10.1128/aac.00997-15.

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ABSTRACTThe generation of new antileishmanial drugs has become a priority. Selenium and its derivatives stand out as having promising leishmanicidal activity. In fact, some parasites express selenoproteins and metabolize selenium. Recently, selenium derivatives have shown the potential to reduce parasitemia, clinical manifestations, and mortality in parasite-infected mice. In this paper, after selecting four candidates according to drug similarity parameters, we observed that two of them, called compounds 2b [methyl-N,N′-di(thien-2-ylcarbonyl)-imidoselenocarbamate] and 4b [methyl-N,N′-di(5-nit

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25

Koide, Tatsuo, Mitsuhiko Nose, Yuiko Ogihara, Yoshisada Yabu, and Nobuo Ohta. "Leishmanicidal Effect of Curcumin in Vitro." Biological & Pharmaceutical Bulletin 25, no. 1 (2002): 131–33. http://dx.doi.org/10.1248/bpb.25.131.

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26

Kayser, O., A. F. Kiderlen, U. Folkens, and H. Kolodziej. "In Vitro Leishmanicidal Activity of Aurones." Planta Medica 65, no. 4 (1999): 316–19. http://dx.doi.org/10.1055/s-1999-13993.

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27

Machado, Patrícia de Almeida, Monique Pacheco Duarte Carneiro, Ariane de Jesus Sousa-Batista, et al. "Leishmanicidal therapy targeted to parasite proteases." Life Sciences 219 (February 2019): 163–81. http://dx.doi.org/10.1016/j.lfs.2019.01.015.

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28

Richomme, Pascal, Marie-Chantal Godet, Françoise Foussard, Loïc Toupet, Thierry Sévenet, and Jean Bruneton. "A Novel Leishmanicidal Labdane fromPolyalthia macropoda." Planta Medica 57, no. 06 (1991): 552–54. http://dx.doi.org/10.1055/s-2006-960204.

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29

Alvarenga, Nelson, N. Canela, R. Gómez, G. Yaluff, and M. Maldonado. "Leishmanicidal activity of Maytenus illicifolia roots." Fitoterapia 79, no. 5 (2008): 381–83. http://dx.doi.org/10.1016/j.fitote.2008.03.001.

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30

Alizadeh, Babak Heidary, Alireza Foroumadi, Susan K. Ardestani, Fatemeh Poorrajab, and Abass Shafiee. "Leishmanicidal Evaluation of Novel Synthetic Chromenes." Archiv der Pharmazie 341, no. 12 (2008): 787–93. http://dx.doi.org/10.1002/ardp.200800128.

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31

Noorpisheh Ghadimi, Shamsi, Negin Sharifi, and Mahmoud Osanloo. "The leishmanicidal activity of essential oils: A systematic review." Journal of Herbmed Pharmacology 9, no. 4 (2020): 300–308. http://dx.doi.org/10.34172/jhp.2020.38.

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Leishmaniasis is the neglected disease among parasitic diseases with an increasing rate of infections. Recently, numerous studies have been conducted on the leishmanicidal properties of various essential oils (EOs). In this research, literature have been systematically reviewed, from 20 years ago, and required information have been extracted. Overally, leishmanicidal effects of ~180 EOs against promastigotes of nine species of Leishmania havebeen documented. Inhibitory concentrations 50% (IC50) of around 30 EOs were less than 10 μg.mL-1. EOs of Tetradenia riparia, Nectandra hihua, and Thymus h

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32

LIMA, LUCIANA A. R. S., TÂNIA M. A. ALVES, CARLOS L. ZANI, et al. "In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae)." Anais da Academia Brasileira de Ciências 86, no. 2 (2014): 829–39. http://dx.doi.org/10.1590/0001-3765201420130048.

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Annona cornifolia A. St. -Hil. is a small annual perennial tree found in the Brazilian savannah; their green fruit is popularly used in the treatment of ulcers. The acetogenins isolated from the seeds of Annona cornifolia previously showed to possess antioxidant activity. In continuation of our investigations on the biological activities of acetogenins, four binary mixtures and ten pure adjacent bis-tetrahydrofuran annonaceous acetogenins were evaluated: the cytotoxic (against three human tumor cell lines), antifungal (against Paracoccidioides brasiliensis), trypanocidal (against Trypanosoma c

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33

Naujorks, Aline Alves dos Santos, Adriano Olímpio da Silva, Rosangela da Silva Lopes, et al. "Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities." Organic & Biomolecular Chemistry 13, no. 2 (2015): 428–37. http://dx.doi.org/10.1039/c4ob01869a.

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34

Ahmad, Aftab, Fatima Syed, Akram Shah, et al. "Silver and gold nanoparticles from Sargentodoxa cuneata: synthesis, characterization and antileishmanial activity." RSC Advances 5, no. 90 (2015): 73793–806. http://dx.doi.org/10.1039/c5ra13206a.

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35

Delorenzi, Jan Carlo, Márcia Attias, Cerli R. Gattass, et al. "Antileishmanial Activity of an Indole Alkaloid fromPeschiera australis." Antimicrobial Agents and Chemotherapy 45, no. 5 (2001): 1349–54. http://dx.doi.org/10.1128/aac.45.5.1349-1354.2001.

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ABSTRACT In this study, we show the leishmanicidal effects of a chloroform fraction (CLF) and a purified indole alkaloid obtained from crude stem extract of Peschiera australis againstLeishmania amazonensis, a causative agent of cutaneous leishmaniasis in the New World. In a bioassay-guided chemical fractionation, the leishmanicidal activity in CLF completely and irreversibly inhibited promastigote growth. This fraction was also active against amastigotes in infected murine macrophages. Chemical analysis of CLF identified an iboga-type indole alkaloid coronaridine as one of its major compounds

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36

Félix, Mayara Barbalho, Rodrigo Santos Aquino de Araújo, Renata Priscila Costa Barros, et al. "Computer-Assisted Design of Thiophene-Indole Hybrids as Leishmanial Agents." Current Topics in Medicinal Chemistry 20, no. 19 (2020): 1704–19. http://dx.doi.org/10.2174/1568026620666200616142120.

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Background: Chemoinformatics has several applications in the field of drug design, helping to identify new compounds against a range of ailments. Among these are Leishmaniasis, effective treatments for which are currently limited. Objective: To construct new indole 2-aminothiophene molecules using computational tools and to test their effectiveness against Leishmania amazonensis (sp.). Methods: Based on the chemical structure of thiophene-indol hybrids, we built regression models and performed molecular docking, and used these data as bases for design of 92 new molecules with predicted pIC50 a

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37

Delgado-Altamirano, Ronna, Rosa López-Palma, Lianet Monzote, et al. "Chemical Constituents with Leishmanicidal Activity from a Pink-Yellow Cultivar of Lantana camara var. aculeata (L.) Collected in Central Mexico." International Journal of Molecular Sciences 20, no. 4 (2019): 872. http://dx.doi.org/10.3390/ijms20040872.

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Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI–FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXV

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38

Etxebeste-Mitxeltorena, Mikel, Daniel Plano, Socorro Espuelas, et al. "New Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione Reductase." Antimicrobial Agents and Chemotherapy 65, no. 1 (2020): e00524-20. http://dx.doi.org/10.1128/aac.00524-20.

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ABSTRACTTwo new series of 28 selenocyanate and diselenide derivatives containing amide moieties were designed, synthesized, and evaluated for their leishmanicidal activity against Leishmania infantum axenic amastigotes, and selectivity was assessed in human THP-1 cells. Eleven compounds exhibited excellent leishmanicidal activity with EC50 values lower than the reference drug miltefosine (EC50 = 2.84 μM). In addition, for six of them the selectivity index ranged from 9 to >1,442, greater than both references used. The most potent and selective compounds were compounds 2h, 2k, and 2m that di

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39

Grekov, Igor, António R. Pombinho, Tatyana Kobets, Petr Bartůněk, and Marie Lipoldová. "Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/1309485.

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Leishmaniasis is an infectious disease caused by protozoan parasites of the genus Leishmania. There is no vaccine against human leishmaniasis and the treatment of the disease would benefit from a broader spectrum and a higher efficacy of leishmanicidal compounds. We analyzed the leishmanicidal activity and the mechanism of action of the calcium ionophore, calcimycin. L. major promastigotes were coincubated with calcimycin and the viability of the cells was assessed using resazurin assay. Calcimycin displayed dose-dependent effect with IC50 = 0.16 μM. Analysis of propidium iodide/LDS-751 staine

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40

NAVARRO, P., M. SÁNCHEZ-MORENO, C. MARÍN, et al. "In vitro leishmanicidal activity of pyrazole-containing polyamine macrocycles which inhibit the Fe-SOD enzyme of Leishmania infantum and Leishmania braziliensis species." Parasitology 141, no. 8 (2014): 1031–43. http://dx.doi.org/10.1017/s0031182014000201.

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SUMMARYThe in vitro leishmanicidal activity and cytotoxicity of pyrazole-containing macrocyclic polyamines 1–4 was assayed on Leishmania infantum and Leishmania braziliensis species. Compounds 1–4 were more active and less toxic than glucantime and both infection rates and ultrastructural alterations confirmed that 1 and 2 were highly leishmanicidal and induced extensive parasite cell damage. Modifications in the excretion products of parasites treated with 1–3 were also consistent with substantial cytoplasm alterations. Compound 2 was highlighted as a potent inhibitor of Fe-SOD in both specie

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41

de Souza, Rodrigo Octavio M. A., José C. Barros, Joaquim F. M. da Silva, and Octavio A. C. Antunes. "Quantitative Structure-Activity Relationship of Morita-Baylis-Hillman Adducts with Leishmanicidal Activity." Zeitschrift für Naturforschung C 66, no. 3-4 (2011): 136–42. http://dx.doi.org/10.1515/znc-2011-3-407.

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A quantitative structure-activity relationship model for Morita-Baylis-Hillman adducts with leishmanicidal activities was developed which correlates molecular orbital energy and dipole with percentage in the promastigote stage

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42

Araújo, Morgana V., Aline C. Queiroz, João F. M. Silva, et al. "Flavonoids induce cell death in Leishmania amazonensis: in vitro characterization by flow cytometry and Raman spectroscopy." Analyst 144, no. 17 (2019): 5232–44. http://dx.doi.org/10.1039/c9an00948e.

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The present study investigated gossypetin 3,7,8,4′-tetra-O-methyl ether (1) and kaempferol 3,7-di-O-methyl ether (3) which showed significant leishmanicidal activity without toxic effects to host cells.

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Hockertz, S., M. Baccarini, and M. L. Lohmann-Matthes. "Functional heterogeneity of macrophage precursor cells from spleen of Leishmania donovani-infected and untreated mice." Journal of Immunology 142, no. 7 (1989): 2489–94. http://dx.doi.org/10.4049/jimmunol.142.7.2489.

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Abstract We recently described the bone marrow-derived macrophage precursor, which is able to spontaneously and extracellularly kill protozoa of the genus Leishmania. These nonadherent, nonphagocytic macrophage precursor cells are present in the spleen of healthy mice only in a small quantity. However, high numbers of proliferating macrophage precursors are isolated from the spleen of Leishmania donovani-infected mice. Macrophage precursors from spleens of diseased animals are able to kill spontaneously the promastigote as well as the amastigote form of L. donovani. The mechanism of the sponta

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44

Borges, Alice P., Malu M. S. Obata, Silvia H. Libardi, et al. "Gold(I) and Silver(I) Complexes Containing Hybrid Sulfonamide/Thiourea Ligands as Potential Leishmanicidal Agents." Pharmaceutics 16, no. 4 (2024): 452. http://dx.doi.org/10.3390/pharmaceutics16040452.

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Leishmaniasis is a group of parasitic diseases with the potential to infect more than 1 billion people; however, its treatment is still old and inadequate. In order to contribute to changing this view, this work consisted of the development of complexes derived from MI metal ions with thioureas, aiming to obtain potential leishmanicidal agents. The thiourea ligands (HLR) were obtained by reactions of p-toluenesulfohydrazide with R-isothiocyanates and were used in complexation reactions with AgI and AuI, leading to the formation of complexes of composition [M(HLR)2]X (M = Ag or Au; X = NO3− or

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Vieira, Ana Carolina Santana, Mariana da Silva Santos, Anderson Brandão Leite, et al. "Leishmanicidal activity of Morita-Baylis–Hillman adducts." Parasitology Research 121, no. 2 (2022): 751–62. http://dx.doi.org/10.1007/s00436-021-07421-3.

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G., Wilson, Winston Quiñones F., and Fernando L. "Leishmanicidal Activity of Passifloricin A and Derivatives." Molecules 9, no. 8 (2004): 666–72. http://dx.doi.org/10.3390/90800666.

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Mendes do Nascimento, Andréa, Fernanda Cristina Costa, Otavio Henrique Thiemann, and Dionéia Camilo Rodrigues de Oliveira. "Chromanones with Leishmanicidal Activity from Calea uniflora." Zeitschrift für Naturforschung C 62, no. 5-6 (2007): 353–56. http://dx.doi.org/10.1515/znc-2007-5-606.

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The dichloromethane extract of Calea uniflora afforded a mixture of two novel chromanones, uniflorol-A (1) and uniflorol-B (2), and one known chromanone, 2,2-dimethyl-6- (1-hydroxyethyl)-chroman-4-one (3). The structures of these compounds were determined by spectroscopic methods. Biological activity of the compounds against Leishmania major promastigotes was evaluated. Mixture of the novel chromanones 1 and 2 showed significant growth inhibition of the parasite in the micrograms per milliliter range.

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Azzouz, Samira, Mimoun Maache, Ramon Gil Garcia, and Antonio Osuna. "Leishmanicidal Activity of Edelfosine, Miltefosine and Ilmofosine." Basic Clinical Pharmacology Toxicology 96, no. 1 (2005): 60–65. http://dx.doi.org/10.1111/j.1742-7843.2005.pto960109.x.

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Mangoni, Maria Luisa, José M. Saugar, Maria Dellisanti, Donatella Barra, Maurizio Simmaco, and Luis Rivas. "Temporins, Small Antimicrobial Peptides with Leishmanicidal Activity." Journal of Biological Chemistry 280, no. 2 (2004): 984–90. http://dx.doi.org/10.1074/jbc.m410795200.

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Marr, Alexandra K., Bradford S. McGwire, and W. Robert McMaster. "Modes of action of Leishmanicidal antimicrobial peptides." Future Microbiology 7, no. 9 (2012): 1047–59. http://dx.doi.org/10.2217/fmb.12.85.

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