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Journal articles on the topic 'Lens'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kurosaka, Daijiro, Toshiyasu Imaizumi, and Junya Kizawa. "Time Course of Lens Epithelial Cell Behavior in Rabbit Eyes following Lens Extraction and Implantation of Intraocular Lens." Journal of Ophthalmology 2021 (January 16, 2021): 1–8. http://dx.doi.org/10.1155/2021/6659838.

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Background. After cataract surgery, some lens epithelial cells (LECs) transdifferentiate into myofibroblast-like cells, which causes fibric posterior capsule opacification (PCO). Residual LECs differentiate into lens fiber cells, forming Elschnig pearls with PCO. This study was carried out to identify the time course of both types of LEC behavior in rabbit eyes following lens extraction and implantation of an intraocular lens (IOL). Methods. Phacoemulsification and implantation of posterior chamber IOLs were performed in rabbit eyes. Following enucleation, immunohistochemical methods were used

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2

Novo, Samuel G., Adam P. Faranda, Mahbubul H. Shihan, Yan Wang, Ananya Garg, and Melinda K. Duncan. "The Immediate Early Response of Lens Epithelial Cells to Lens Injury." Cells 11, no. 21 (2022): 3456. http://dx.doi.org/10.3390/cells11213456.

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Cataracts are treated by lens fiber cell removal followed by intraocular lens (IOL) implantation into the lens capsule. While effective, this procedure leaves behind numerous lens epithelial cells (LECs) which undergo a wound healing response that frequently leads to posterior capsular opacification (PCO). In order to elucidate the acute response of LECs to lens fiber cell removal which models cataract surgery (post cataract surgery, PCS), RNA-seq was conducted on LECs derived from wild type mice at 0 and 6 h PCS. This analysis found that LECs upregulate the expression of numerous proinflammat

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3

Xiong, Lang, Yan Sun, Jingqi Huang, et al. "Long Non-Coding RNA H19 Prevents Lens Fibrosis through Maintaining Lens Epithelial Cell Phenotypes." Cells 11, no. 16 (2022): 2559. http://dx.doi.org/10.3390/cells11162559.

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The integrity of lens epithelial cells (LECs) lays the foundation for lens function and transparency. By contrast, epithelial-mesenchymal transition (EMT) of LECs leads to lens fibrosis, such as anterior subcapsular cataracts (ASC) and fibrotic forms of posterior capsule opacification (PCO). However, the underlying mechanisms remain unclear. Here, we aimed to explore the role of long non-coding RNA (lncRNA) H19 in regulating TGF-β2-induced EMT during lens fibrosis, revealing a novel lncRNA-based regulatory mechanism. In this work, we identified that lncRNA H19 was highly expressed in LECs, but

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4

Andjelic, Sofija, and Marko Hawlina. "Human Primary Lens Epithelial Cultures on Basal Laminas Studied by Synchrotron-Based FTIR Microspectroscopy for Understanding Posterior Capsular Opacification." International Journal of Molecular Sciences 25, no. 16 (2024): 8858. http://dx.doi.org/10.3390/ijms25168858.

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Human primary lens epithelial cultures serve as an in vitro model for posterior capsular opacification (PCO) formation. PCO occurs when residual lens epithelial cells (LECs) migrate and proliferate after cataract surgery, differentiating into fibroblastic and lens fiber-like cells. This study aims to show and compare the bio-macromolecular profiles of primary LEC cultures and postoperative lens epithelia LECs on basal laminas (bls), while also analyzing bls and cultured LECs separately. Using synchrotron radiation-based Fourier transform infrared (SR-FTIR) (Bruker, Karlsruhe, Germany) microspe

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5

Syu, Yong-Sin, and Yung-Chun Lee. "Quantitative Evaluation of Light Collimating for Commercial UV-LEDs Based on Analytic Collimating Lens." Applied Sciences 12, no. 2 (2022): 911. http://dx.doi.org/10.3390/app12020911.

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This paper proposes a lens design method for effectively collimating the light emitting from a light-emitting diode (LED). This collimating lens contains two aspherical lens surfaces which can be mathematically characterized using a few designing parameters, and hence is called an analytic collimating lens. An optical ray-tracing algorithm has been developed for these analytic collimating lenses to analyze their optical performance and to optimize their designs. Six high-power and commercially available ultraviolet (UV) LEDs are chosen as examples for demonstrating the optimal collimating lens

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6

Zhang, Junfang, Jiawei Luo, Guowei Zhang, Bai Qin, Xiumei Ren, and Huaijin Guan. "An Ex Vivo Study on Release, Uptake, and miRNA Profile of Exosomes in Rat Lens." Journal of Ophthalmology 2022 (April 21, 2022): 1–7. http://dx.doi.org/10.1155/2022/6706172.

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Purpose. To identify the ability of releasing and uptaking exosomes in rat lens and characterize the exosomal microRNA profile of lens-derived exosomes. Methods. The rat lenses were cultured ex vivo and the medium was collected. The exosomes were isolated from medium and measured in size and concentration by nanoflow cytometry (nFCM) and transmission electron microscopy (TEM) and verified with CD63 and TSG101 by Western blot. The miRNAs in exosomes released from lens epithelial cells (LECs) were sequenced. The plasma exosomes labeled by PKH26 were used to verify the exosomes uptake LECs, and t

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7

Taiyab, Aftab, Yasmine Belahlou, Vanessa Wong, et al. "Understanding the Role of Yes-Associated Protein (YAP) Signaling in the Transformation of Lens Epithelial Cells (EMT) and Fibrosis." Biomolecules 13, no. 12 (2023): 1767. http://dx.doi.org/10.3390/biom13121767.

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Fibrotic cataracts, posterior capsular opacification (PCO), and anterior subcapsular cataracts (ASC) are mainly attributed to the transforming growth factor-β (TGFβ)-induced epithelial-to-mesenchymal transition (EMT) of lens epithelial cells (LECs). Previous investigations from our laboratory have shown the novel role of non-canonical TGFβ signaling in the progression of EMT in LECs. In this study, we have identified YAP as a critical signaling molecule involved in lens fibrosis. The observed increase in nuclear YAP in capsules of human ASC patients points toward the involvement of YAP in lens

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8

Yoon, Min-Hwa. "Changes of Refractive Correction Value with Different Age Group: A Case for Myopia Control Lens, Single Vision Lens and Reverse Geometry Contact Lens." Journal of Korean Ophthalmic Optics Society 18, no. 1 (2013): 75–84. http://dx.doi.org/10.14479/jkoos.2013.18.1.075.

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9

Shen, Xinyue, Manhui Zhu, Lihua Kang, et al. "Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract." Journal of Ophthalmology 2018 (July 11, 2018): 1–9. http://dx.doi.org/10.1155/2018/4125893.

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Purpose. Lanosterol synthase (LSS) abnormity contributes to lens opacity in rats, mice, dogs, and human congenital cataract development. This study examined whether LSS pathway has a role in different subtypes of age-related cataract (ARC). Methods. A total of 390 patients with ARC and 88 age-matched non-ARC patients were enrolled in this study. LSS expression was analyzed by western blot and enzyme-linked immunosorbent assay (ELISA). To further examine the function of LSS, we used U18666A, an LSS inhibitor in rat lens culture system. Results. In lens epithelial cells (LECs), LSS expression in

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10

Ruan, Xiaoting, Zhenzhen Liu, Lixia Luo, and Yizhi Liu. "The Structure of the Lens and Its Associations with the Visual Quality." BMJ Open Ophthalmology 5, no. 1 (2020): e000459. http://dx.doi.org/10.1136/bmjophth-2020-000459.

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In humans, the lens is the organ with the ability to change morphology and refractive power, designated as accommodation, to focus light from various distances and obtain clear retinal image. The accommodative ability of the lens depends on its structure and biological parameters. The lens grows throughout the life, forming specific lens sutures and a unique gradient refractive index, and possesses regenerative ability under certain circumstances. Minimally invasive lens surgery that preserves endogenous lens epithelial stem/progenitor cells (LECs) can achieve functional lens regeneration in h

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11

Zhang, Rong-Pei, and Zheng-Gao Xie. "Research Progress of Drug Prophylaxis for Lens Capsule Opacification after Cataract Surgery." Journal of Ophthalmology 2020 (July 4, 2020): 1–9. http://dx.doi.org/10.1155/2020/2181685.

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Phacoemulsification combined with intraocular lens (IOL) implantation is the international standard operation procedure for cataract and has been generalized worldwide. However, lens capsule opacification, one of the common complications after cataract surgery, impacts the recovery of patients’ visual function to a large extent. Lens capsule opacification has two types, anterior capsule opacification (ACO) and posterior capsule opacification (PCO), according to the location. There is not an accepted approach to treat ACO. Nd : YAG laser capsulotomy, the common treatment of PCO, can effectively

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12

Shibata, Shinsuke, Naoko Shibata, Satoshi Ohtsuka, et al. "Role of Decorin in Posterior Capsule Opacification and Eye Lens Development." Cells 10, no. 4 (2021): 863. http://dx.doi.org/10.3390/cells10040863.

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Decorin (DCN) is involved in a variety of physiological and pathological processes. Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) has been proposed as a major cause for the development of posterior capsule opacification (PCO) after cataract surgery. We investigated the plausible target gene(s) that suppress PCO. The expression of Dcn was significantly upregulated in rat PCO tissues compared to that observed in the control using a microarray-based approach. LECs treated with fibroblast growth factor (FGF) 2 displayed an enhanced level of DCN expression, while LECs trea

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13

Yang, Qing, Siyu Tong, Feng Chen, et al. "Lens-on-lens microstructures." Optics Letters 40, no. 22 (2015): 5359. http://dx.doi.org/10.1364/ol.40.005359.

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14

Kubo, Eri, Teppei Shibata, Dhirendra Singh та Hiroshi Sasaki. "Roles of TGF β and FGF Signals in the Lens: Tropomyosin Regulation for Posterior Capsule Opacity". International Journal of Molecular Sciences 19, № 10 (2018): 3093. http://dx.doi.org/10.3390/ijms19103093.

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Transforming growth factor (TGF) β and fibroblast growth factor (FGF) 2 are related to the development of posterior capsule opacification (PCO) after lens extraction surgery and other processes of epithelial–mesenchymal transition (EMT). Oxidative stress seems to activate TGF β1 largely through reactive oxygen species (ROS) production, which in turn alters the transcription of several survival genes, including lens epithelium-cell derived growth factor (LEDGF). Higher ROS levels attenuate LEDGF function, leading to down-regulation of peroxiredoxin 6 (Prdx6). TGF β is regulated by ROS in Prdx6

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15

Markiewicz, Ewa, Stephen Barnard, Jackie Haines, et al. "Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape." Open Biology 5, no. 4 (2015): 150011. http://dx.doi.org/10.1098/rsob.150011.

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Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still understood about the biological responses of the lens to low-dose ionizing radiation (IR). Here, we show for the first time that in mice, lens epithelial cells (LECs) in the peripheral region repair DNA double strand breaks (DSB) after exposure to 20 and 100 mGy more slowly compared with circulating blood lymphocytes, as demonstrated by counts of γH2AX f

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16

Ishida, Hidetoshi, Teppei Shibata, Yuka Nakamura, et al. "Identification of Differential Gene Expression Pattern in Lens Epithelial Cells Derived from Cataractous and Noncataractous Lenses of Shumiya Cataract Rat." BioMed Research International 2020 (November 2, 2020): 1–9. http://dx.doi.org/10.1155/2020/7319590.

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The Shumiya cataract rat (SCR) is a model for hereditary cataract. Two-thirds of these rats develop lens opacity within 10-11 weeks. Onset of cataract is attributed to the synergetic effect of lanosterol synthase (Lss) and farnesyl-diphosphate farnesyltransferase 1 (Fdft1) mutant alleles that lead to cholesterol deficiency in the lenses, which in turn adversely affects lens biology including the growth and differentiation of lens epithelial cells (LECs). Nevertheless, the molecular events and changes in gene expression associated with the onset of lens opacity in SCR are poorly understood. In

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17

Zhu, L., A. Ge, Z. Ge, R. Hao, J. Chen, and X. Tao. "A Fresnel freeform surface collimating lens for LEDs." Lighting Research & Technology 50, no. 6 (2017): 952–60. http://dx.doi.org/10.1177/1477153517712780.

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This paper proposes a freeform surface lens design based on the Fresnel model to achieve a compact structure and good collimation. A simulation indicates the lens enjoys an efficiency as high as 88.43% within a half view angle of 2° for 1 × 1 mm2 size LED. This paper makes a comparison of three types of lens, among which the Fresnel freeform lens achieves the best performance when the LED size is smaller than 2.5 × 2.5 mm2. The influence of the LED size and the manufacturing tolerances are discussed.

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18

Joo, Jae Young, Chang Suk Kang, Soon Sub Park, and Sun Kyu Lee. "Fabrication of a Beam Shaping Lens for Chip Scale Packaged LEDs." Key Engineering Materials 447-448 (September 2010): 101–5. http://dx.doi.org/10.4028/www.scientific.net/kem.447-448.101.

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In this paper, we demonstrated the machining process of a novel Light Emitting Diodes (LED) beam shaping lens, called TIR Fresnel lens, for GaN-based blue Chip Scale Packaged (CSP) LEDs. Upon achieving a precise alignment of the tool and identifying the best manufacturing condition, we have successfully fabricated a prototype of this lens on poly methyl methacrylate (PMMA) plate. The form error of the central aspheric lens was less than 1 μm deviation, and surface quality of the Fresnel facets were sufficient for Total Internal refraction without any burr or adhesion of the machined chip. Fabr

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19

Syu, Yong-Sin, Chun-Ying Wu, and Yung-Chun Lee. "Double-Sided Freeform Lens for Light Collimation of Light Emitting Diodes." Applied Sciences 9, no. 24 (2019): 5452. http://dx.doi.org/10.3390/app9245452.

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A double-sided freeform lens is proposed for collimating light emitted from light emitting diodes (LEDs). The surface profiles of the lens are mathematically characterized and precisely determined based on a point-source assumption and differential geometry theory. The proposed lens design method is straightforward, flexible, and effective. Moreover, the optical performance of the lens can be intuitively adjusted by tuning just a small number of design parameters. The simulation results showed that the proposed lens achieved an excellent collimating effect for a commercial ultraviolet (UV) LED

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20

Park, Byoung Guk, Kiwoon Choi, Chul Jin Jo, and Han Sup Lee. "Micro lens-on-lens array." Soft Matter 8, no. 6 (2012): 1751–55. http://dx.doi.org/10.1039/c2sm06988a.

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21

Smith, Warren J. "Lens design and lens designers." Optics News 14, no. 6 (1988): 29. http://dx.doi.org/10.1364/on.14.6.000029.

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22

Joveini, F., and M. Akbari. "SCHWARZ PROBLEM IN LENS AND HALF LENS." Eurasian Mathematical Journal 10, no. 2 (2019): 49–64. http://dx.doi.org/10.32523/2077-9879-2019-10-2-49-64.

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23

Binkhorst, C. D. "The Lens Capsule and the Intraocular Lens-the ‘Moustache Lens’." European Journal of Implant and Refractive Surgery 1, no. 1 (1989): 62–64. http://dx.doi.org/10.1016/s0955-3681(89)80040-1.

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24

Azarifar, Mohammad, Ceren Cengiz, and Mehmet Arik. "Optical and Thermal Analysis of Secondary Optics in Light Emitting Diodes’ Packaging: Analysis of MR16 Lamp." Journal of Physics: Conference Series 2116, no. 1 (2021): 012121. http://dx.doi.org/10.1088/1742-6596/2116/1/012121.

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Abstract Optical and thermal control are two main factors in package design process of lighting products, specifically light emitting diodes (LEDs). This research is aimed to study the role of secondary optics in opto-thermal characterization of LED packages. Novel thin total internal reflection (TIR) multifaceted reflector (MR) lens is modelled and optimized in Monte-Carlo ray-tracing simulations for MR16 package, regarded as one of the widely used LED lighting products. With criteria of designing an optical lens with 50% reduced thickness in comparison to commercially available lenses utiliz

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25

Chao, Paul C. P., Lun De Liao, Chi Wei Chiu, and Chien Yu Shen. "Enhancement of the Optical Performances for the LED Backlight Systems with a Novel Dual Lens-Cap." Key Engineering Materials 364-366 (December 2007): 132–37. http://dx.doi.org/10.4028/www.scientific.net/kem.364-366.132.

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A novel dual-cone-shaped side-emitting lens cap for High Brightness Light Emitting Diodes (HB-LEDs) is proposed for improving brightness and high uniformity of the direct LED backlight Units (BLUs) for large-sized LCD-TVs. Combining the designed lens cap with red, green and blue (RGB) chips on a Metal Core Printed Circuit Board (MCPCB), the LED module with the proposed cap is able to provide a compact white light source with unique features such as instant color variability and lower power usage, etc. The dual-cone-shaped of the proposed lens cap is designed to emit most of the light rays to t

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Flokis, Mary, та Frank J. Lovicu. "FGF-2 Differentially Regulates Lens Epithelial Cell Behaviour during TGF-β-Induced EMT". Cells 12, № 6 (2023): 827. http://dx.doi.org/10.3390/cells12060827.

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Fibroblast growth factor (FGF) and transforming growth factor-beta (TGF-β) can regulate and/or dysregulate lens epithelial cell (LEC) behaviour, including proliferation, fibre differentiation, and epithelial–mesenchymal transition (EMT). Earlier studies have investigated the crosstalk between FGF and TGF-β in dictating lens cell fate, that appears to be dose dependent. Here, we tested the hypothesis that a fibre-differentiating dose of FGF differentially regulates the behaviour of lens epithelial cells undergoing TGF-β-induced EMT. Postnatal 21-day-old rat lens epithelial explants were treated

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27

Taler, Kineret, Nour Zatari, Mohammad Iqbal Lone, Shahar Rotem-Bamberger, and Adi Inbal. "Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish." Cells 12, no. 21 (2023): 2540. http://dx.doi.org/10.3390/cells12212540.

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Cataract is the leading cause of blindness worldwide. It can be treated by surgery, whereby the damaged crystalline lens is replaced by a synthetic lens. Although cataract surgery is highly effective, a relatively common complication named posterior capsular opacification (PCO) leads to secondary loss of vision. PCO is caused by abnormal proliferation and migration of residual lens epithelial cells (LECs) that were not removed during the surgery, which results in interruption to the passage of light. Despite technical improvements to the surgery, this complication has not been eradicated. Effo

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28

Rogers, Andrea L. "Lens." Massachusetts Review 61, no. 4 (2020): 751–57. http://dx.doi.org/10.1353/mar.2020.0121.

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29

Semerci̇oğlu, Meli̇ke Güzi̇n. "Lens Tasarımcısının Optik Lens Geliştirme Süreçleri." International Journal of Innovative Approaches in Science Research 6, no. 2 (2022): 116–32. http://dx.doi.org/10.29329/ijiasr.2022.454.8.

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30

Hendriks, B., and S. Kuiper. "Through a lens sharply [FluidFocus lens." IEEE Spectrum 41, no. 12 (2004): 32–36. http://dx.doi.org/10.1109/mspec.2004.1363638.

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31

Park, Sung Chan. "Zoom lens design using lens modules." Optical Engineering 35, no. 6 (1996): 1668. http://dx.doi.org/10.1117/1.600742.

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32

Whittle, J. "Contact lens optics and lens design." Eye 21, no. 7 (2007): 1022. http://dx.doi.org/10.1038/sj.eye.6702607.

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33

Terazima, Masahide, and Noboru Hirota. "Population lens in thermal lens spectroscopy." Journal of Physical Chemistry 96, no. 18 (1992): 7147–50. http://dx.doi.org/10.1021/j100197a001.

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34

Mahelková, Gabriela, L. Bačáková, J. Korynta, L. Vajner та R. Vytásek. "Effect of Culture Substrate and Culture Conditions on Lens Epithelial Cell Proliferation and α-smooth Muscle Actin Expression". Folia Biologica 55, № 2 (2009): 66–76. http://dx.doi.org/10.14712/fb2009055020066.

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The most common complication following cataract surgery is posterior capsule opacification. This results from migration, proliferation and transdifferentiation of residual lens epithelial cells (LECs). We studied the effect of several culture substrates and culture conditions on LEC proliferation and α-smooth muscle actin (α-SMA) expression. We used primary and secondary cultures of porcine LECs cultivated on collagen I, collagen IV, microscopic glass slides, and uncoated plastic dishes. We studied the cell proliferation and expression of α-SMA and α-, β-, and γ-crystallins. The effect of the

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35

Chien, Ming-Chin, and Chung-Hao Tien. "Cluster LEDs mixing optimization by lens design techniques." Optics Express 19, S4 (2011): A804. http://dx.doi.org/10.1364/oe.19.00a804.

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36

Rizky Hidayat Prasetyo and Eko Tjipto Rahardjo. "Rotman Lens Size Reduction by Using Same-Size Double Rectangular Defected Ground Structures (DGSs) Method or Same-Size Double Rectangular Slots Method." Journal of Robotics, Automation, and Electronics Engineering 2, no. 1 (2024): 30–38. http://dx.doi.org/10.21831/jraee.v2i1.555.

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The need for dedicated communication keeps increasing. A technique to realize that is by using multibeam radiation. A Beamforming Network (BFN) is required to enable multibeam capability in array antennas. This study uses the Rotman Lens as BFN in the frequency of S-Band. The common problem with using Rotman Lens is that its conventional design size is quite large, mainly due to its transition leg ports. Transition leg ports are important to ensure the matching impedance between the lens and the array antenna ports the lens and the beam ports or the lens and the dummy port. The goal of this st

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Gong, Yingying, Qingquan Wei, Liying Luo, Wei Qiu, and Yanyun Jiang. "A lipidomic study on the lens epithelial cells of patients with age related cataracts." PeerJ 12 (September 6, 2024): e17998. http://dx.doi.org/10.7717/peerj.17998.

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Age related cataracts (ARC) represent the main reason for blindness globally. The lens epithelial cells (LECs) participate not only in the metabolism of many substances in the lens but also in maintaining lens transparency. This study used lipidomics to investigate the metabolic differences in LECs of ARC patients with different severity, aiming at identifying potential metabolic biomarkers of ARC. Patients diagnosed with ARC and underwent cataract surgery at Shanghai Tongren Hospital were selected to participate in this study, which were classified as mild ARC group and severe ARC group. Duri

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38

Qin, Ying, Haoxin Liu, and Hongli Wu. "Cellular Senescence in Health, Disease, and Lens Aging." Pharmaceuticals 18, no. 2 (2025): 244. https://doi.org/10.3390/ph18020244.

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Background: Cellular senescence is a state of irreversible cell cycle arrest that serves as a critical regulator of tissue homeostasis, aging, and disease. While transient senescence contributes to development, wound healing, and tumor suppression, chronic senescence drives inflammation, tissue dysfunction, and age-related pathologies, including cataracts. Lens epithelial cells (LECs), essential for maintaining lens transparency, are particularly vulnerable to oxidative stress-induced senescence, which accelerates lens aging and cataract formation. This review examines the dual role of senesce

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Nurama, Linda, and Swono Sibagariang*. "Sistem Informasi Persediaan Dry Lens Untuk Lensa Kontak Berbasis WEB." JURNAL MAHAJANA INFORMASI 7, no. 1 (2022): 42–49. http://dx.doi.org/10.51544/jurnalmi.v7i1.2953.

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Sistem yang baik mampu memberikan informasi dengan data yang akurat dan tepat dalam proses pengolahannya. Salah satu faktor yang terjadi di department Planning PT CIBA VISION BATAM adalah pencatatan informasi quantity per cavity untuk Dry Lens Air Optix Night and Day masih menggunakan file excel dimana semakin panjang file maka akan menyebabkan file yang akan dibuka lebih lambat. Data yang disimpan dalam file Microsoft Excel juga sangat tidak efektif karena jika terjadi kesalahan pada saat data diproses akan menyebabkan ketidaksesuaian informasi dan kehilangan data yang disebabkan oleh human e

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Boateng, Akosua K., Roy Joseph та Om P. Srivastava. "G91-deletion in βA3/A1-crystallin induces cellular and molecular changes in mouse lenses leading to congenital cataract development". PLOS One 20, № 7 (2025): e0326305. https://doi.org/10.1371/journal.pone.0326305.

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CRYβA1-ΔG91 (βA3ΔG91) is a mutational hotspot in CRYβA1, which causes autosomal dominant congenital nuclear cataract in humans and mice. Previous in-vitro studies of recombinant βA3ΔG91 showed defective folding, decreased solubility, and aberrant oligomerization of βA3ΔG91 with other crystallins. Emerging evidence demonstrates an association between autophagy and βA3ΔG91-induced congenital cataracts. To gain further understanding of the molecular mechanism of congenital cataract development in βA3ΔG91 mice, we examined the βA3ΔG91- vs WT- lenses for complete gene profiling, lens epithelial cel

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Wu, Tsung-Tien, Ying-Ying Chen, Chiu-Yi Ho, et al. "3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus." Antioxidants 10, no. 7 (2021): 1086. http://dx.doi.org/10.3390/antiox10071086.

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Studies demonstrated that the receptor of advanced glycation end products (RAGE) induced epithelial-mesenchymal transition (EMT) formation in the lens epithelial cells (LECs) of diabetic cataracts. This work investigated how 3H-1,2-dithiole-3-thione (D3T) reduces EMT formation in LECs of the fructose-induced diabetes mellitus (DM). LECs were isolated during cataract surgery from patients without DM or with DM. In a rat model, fructose (10% fructose, eight weeks) with or without D3T (10 mg/kg/day) treatment induced DM, as verified by blood pressure and serum parameter measurements. We observed

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Lipnitskaya, S. N., I. I. Dudko, and I. G. Smirnova. "Numerical Simulation of Light Extraction from Remote Phosphor LED." Reviews on Advanced Materials and Technologies 4, no. 3 (2022): 35–41. http://dx.doi.org/10.17586/2687-0568-2022-4-3-35-41.

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In this paper, light extraction from remote phosphor LEDs were calculated in Zemax OpticStudio. The dependence of the optical characteristics of the remote phosphor LED on the parameters of phosphor and its geometrical form was considered. In case of a thin plate as a remote phosphor, phosphor particle size, phosphor mass fraction and phosphor plate thickness were carefully analyzed. Furthermore, a plane-convex lens and Fresnel lens were also considered as geometrical form of remote phosphor. The simulation results show that color coordinates of LED, using remote phosphor plate (thickness 0.25

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Gosak, Marko, Dajana Gojić, Elena Spasovska, Marko Hawlina, and Sofija Andjelic. "Cataract Progression Associated with Modifications in Calcium Signaling in Human Lens Epithelia as Studied by Mechanical Stimulation." Life 11, no. 5 (2021): 369. http://dx.doi.org/10.3390/life11050369.

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Ca2+ homeostasis and signaling disturbances are associated with lens pathophysiology and are involved in cataract formation. Here, we explored the spatiotemporal changes in Ca2+ signaling in lens epithelial cells (LECs) upon local mechanical stimulation, to better understand the LECs’ intercellular communication and its association with cataractogenesis. We were interested in if the progression of the cataract affects the Ca2+ signaling and if modifications of the Ca2+ homeostasis in LECs are associated with different cataract types. Experiments were done on the human postoperative anterior le

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Dai, Yan, Yuhuan Liu, and Anlang Dai. "Impact of Pterostilbene on Lens Epithelial Cells from Cataract Model Rats." Journal of Biobased Materials and Bioenergy 18, no. 5 (2024): 931–36. http://dx.doi.org/10.1166/jbmb.2024.2443.

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Lens epithelial cell (lEC) membrane is one of the pathological process of cataract. Sandalwood stilbene is a kind of non-flavonoid polyphenol extracted from blueberries, grapes and other berries. It is considered as a natural antioxidant through various related mechanisms. This study was to investigate the effect and mechanism of Rosewood astragalus on lEC in oxidative cataract rats, and to provide evidence for clinical cataract treatment. Grouping method: normal control group, model group (H2O2 induced cataract) and Zitan astragalus group. Lens turbidity was observed, LECs was isolated and cu

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Andjelic, Sofija, Xhevat Lumi, Zoltán Veréb, et al. "A Simple Method for Establishing AdherentEx VivoExplant Cultures from Human Eye Pathologies for Use in Subsequent Calcium Imaging and Inflammatory Studies." Journal of Immunology Research 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/232659.

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A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment and expansion and calcium imaging of cultured cells challenged by mechanical and acetylcholine (ACh) stimulation as well as inflammatory studies. Anterior lens capsule-lens epithelial cells (aLC-LECs) from cataract surgery and proliferative diabetic retinopathy (PDR) fibrovascular epiretinal membranes (fvERMs) from human eyes were used in the study. We hereby show calcium signaling in a

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ZHANG Jin-kai, 张金凯, 陈晓波 CHEN Xiao-bo, 邵海燕 SHAO Hai-yan, 王晓慧 WANG Xiao-hui, and 孙选 SUN Xuan. "Zoom lens design using mixed lens modules." Optics and Precision Engineering 26, no. 1 (2018): 38–47. http://dx.doi.org/10.3788/ope.20182601.0038.

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Vyas, Sameer, Satheesh Krishna, Ajay Kumar, and Niranjan Khandelwal. "′Floating lens sign′ in traumatic lens dislocations." Middle East African Journal of Ophthalmology 22, no. 1 (2015): 129. http://dx.doi.org/10.4103/0974-9233.148365.

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Zhong Liujun, 钟刘军, 安志勇 An Zhiyong, 高铎瑞 Gao Duorui, and 赵昭 Zhao Zhao. "All Lens Elements Movable Zoom Lens Design." Laser & Optoelectronics Progress 51, no. 12 (2014): 122202. http://dx.doi.org/10.3788/lop51.122202.

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Fine, I. Howard, Richard S. Hoffman, and Mark Packer. "Clear-Lens Extraction with Multifocal Lens Implantation." International Ophthalmology Clinics 41, no. 2 (2001): 113–21. http://dx.doi.org/10.1097/00004397-200104000-00011.

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Kuc, Christopher J., and Kenneth A. Lebow. "Contact Lens Solutions and Contact Lens Discomfort." Eye & Contact Lens: Science & Clinical Practice 44, no. 6 (2018): 355–66. http://dx.doi.org/10.1097/icl.0000000000000458.

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