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Relevant bibliographies by topics / Lenti Virus Vector

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Journal articles

Academic literature on the topic 'Lenti Virus Vector'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Lenti Virus Vector"

1

Trobridge, Grant D., Brian C. Beard, David Dickerson, et al. "Transduction of Macaque Hematopoietic Repopulating Cells with Lenti and Foamy Retroviral Vectors with MGMT Selection Cassettes To Evaluate AIDS Gene Therapy Strategies." Blood 108, no. 11 (2006): 3273. http://dx.doi.org/10.1182/blood.v108.11.3273.3273.

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Abstract AIDS remains a significant health problem worldwide despite the advent of highly active antiretroviral therapy (HAART). Although substantial efforts have been made to develop a vaccine there is still no cure and alternative strategies are needed to treat HIV infection and to control its spread. Our goal is to evaluate lenti and foamy retroviral vectors that inhibit HIV replication by RNAi in a non-human primate SHIV model to develop a hematopoietic stem cell (HSC) gene therapy for AIDS. SHIV is a chimeric virus comprised of an SIV genome that contains the tat, rev and env genes of HIV

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2

Trobridge, Grant D., Karen Beagles, Brian Beard, et al. "A Non-Human Primate Model To Study Anti-HIV Gene Therapy Strategies." Blood 106, no. 11 (2005): 3046. http://dx.doi.org/10.1182/blood.v106.11.3046.3046.

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Abstract AIDS remains a significant health problem worldwide despite the advent of highly active antiretroviral therapy (HAART). Although substantial efforts have been made to develop a vaccine there is still no cure and alternative strategies are needed to treat HIV infection and to control its spread. Our goal is to evaluate lenti and foamy retroviral vectors that inhibit HIV replication by RNA interference (RNAi) in a non-human primate SHIV model to develop a hematopoietic stem cell (HSC) gene therapy for AIDS. SHIV is a chimeric virus comprised of an SIV genome that contains the tat, rev a

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3

Simantirakis, Emmanouil, Vassilis Atsaves, Ioannis Tsironis, Margarita Gkyzi, Kostas Konstantopoulos, and George Vassilopoulos. "Foamy Virus Based Vectors for CAR-T Cell Development." Blood 134, Supplement_1 (2019): 4646. http://dx.doi.org/10.1182/blood-2019-123022.

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Introduction A novel approach that can cover the therapeutic gap in NHL treatment are the autologous T cells, expressing Chimeric Antigen Receptors (CAR-T cells) against tumor markers. Such clinical-grade products based on Lenti (LV) or Retro- vectors have hit the market. An alternative vector system for CAR gene transfer in T-cells are Foamy Viruses (FV). To evaluate the potential of FV vectors in CAR-T cell development, we synthesized an antiCD19 scFv cDNA and cloned it in both an FV and an LV backbone; both vectors were tested in paired experiments Material and Methods The anti-CD19 CAR was

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4

Choi, Uimook, Narda Theobald, Throm E. Robert, et al. "High Titer Lentivector from a Stable Lenti-Producer Efficiently Corrects CD34+ Hematopoietic Stem Cells from Patients with p47phox-Deficient Chronic Granulomatous Disease." Blood 126, no. 23 (2015): 2036. http://dx.doi.org/10.1182/blood.v126.23.2036.2036.

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Abstract Chronic granulomatous disease (CGD) is an inherited immune deficiency due to mutations in the genes for the NADPH subunits (the genes for p47phox, p22phox, p67phox, p40phox autosomal chronic granulomatous disease), or gp91phox (X-linked chronic granulomatous disease). This results in a failure to generate phagocyte-derived superoxide and related reactive oxygen intermediates (ROIs), the major defect in chronic granulomatous disease causing recurrent infections and granulomatous complications. Hematopoietic stem cell transplantation (HSCT) with a suitable donor is potentially curative.

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Battula, Venkata Lokesh, Maria da Graca Cabreira, Zhiqiang Wang, et al. "Connective Tissue Growth Factor (CTGF) Is Essential for Self Renewal and Proliferation of Mesenchymal Stromal Cells (MSCs) and Affects Leukemia-Stromal Interactions." Blood 116, no. 21 (2010): 3845. http://dx.doi.org/10.1182/blood.v116.21.3845.3845.

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Abstract Abstract 3845 Connective tissue growth factor (CTGF) is a member of the CCN family of growth factors that are critical regulators of vertebrate development. CTGF is a secreted protein that promotes extracellular matrix production, chemotaxis, cell proliferation and integrin expression. Since CTGF is highly expressed in acute lymphoblastic leukemia (ALL) and CTGF expression levels are related to ALL patient survival (Olga ST et al., Blood, 2007), we hypothesized that CTGF plays a role in regulating stromal cell proliferation and leukemia-stroma interaction. Our first goal was to charac

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Wang, Jishi, Dan Ma, Qin Fang, Ping Wang, Rui Gao, and Jia Sun. "Down-Regulation of HO-1 Promoted Apoptosis Induced By Decitabine Via Increasing p15INK4B Promoter Demethylation in myelodysplastic syndrome." Blood 124, no. 21 (2014): 5213. http://dx.doi.org/10.1182/blood.v124.21.5213.5213.

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Abstract Background: Decitabine, reverts hypermethylation of p15INK4B gene in vitro, was used to improves cytopenias and blast excess in over 50% of patients with high-risk myelodys plastic syndrome (MDS). In this study, over-expression of Heme Oxygenase-1(HO-1) was found in MDS cells line SKM-1 cells, and it was closely related to resistance to apoptosis induced by decitabine. Objective: we aimed to further investigated what role of HO-1 exactly played in apoptosis induced by low-does of decitabine in MDS. Method: CCK-8 kits was used to determine the proliferation inhibition of SKM-1 cells. F

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Chen, Ye, Rodrigo Jacamo, Marina Konopleva, Ramiro Garzon, Carlo M. Croce, and Michael Andreeff. "The Hsa-Let-7a miRNA Enhances Ara-C Induced Apoptosis in Human Acute Myeloid Leukemia Cells." Blood 120, no. 21 (2012): 1286. http://dx.doi.org/10.1182/blood.v120.21.1286.1286.

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Abstract Abstract 1286 CXCR4 surface expression has been reported as an important prognostic marker in AML patients. Our group previously reported that targeting the SDF-1α/CXCR4 axis by CXCR4 inhibition could overcome the resistance of AML cells to chemotherapy both in vitro and in vivo. To further explore the mechanism of targeting CXCR4, we first performed a microRNA microarray platform and revealed that hsa-let-7a as one of the most significantly degraded microRNA in OCI-AML3 cells treated with SDF-1α. Moreover, hsa-let-7a was highly elevated when the OCI-AML3 cells were treated with CXCR4

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8

Chan, Frieda, Olivier Humbert, Troy Torgerson та ін. "Rapid Expansion of Gene-Marked Lymphocytes in X-SCID Dogs after AMD3100+G-CSF-Based Hematopoietic Stem/Progenitor Cell Mobilization and Intravenous Injection of a Common γ-Chain Expressing Foamy Viral Vector". Blood 128, № 22 (2016): 1348. http://dx.doi.org/10.1182/blood.v128.22.1348.1348.

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Abstract In both humans and canines, X-linked severe combined immunodeficiency disease (XSCID) is caused by mutations in the interleukin-2 receptor gamma chain gene (IL2RG) which results in a lack of response to common gamma-chain (gammaC) dependent cytokines and abnormal development of T and B lymphocytes, and natural killer (NK) cells. Death from infections usually occurs before 1 year of age unless allogeneic hematopoietic cell transplantation (HCT) is performed. While HCT is successful if an HLA-matched sibling donor is available, transplants from mismatched and unrelated donors are associ

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Larijani, Mona Sadat, Mohammad Hassan Pouriayevali, Seyed Mehdi Sadat, and Amitis Ramezani. "Production of Recombinant HIV-1 p24-Nef Protein in Two Forms as Potential Candidate Vaccines in Three Vehicles." Current Drug Delivery 17, no. 5 (2020): 387–95. http://dx.doi.org/10.2174/1567201817666200317121728.

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Background: Different approaches have been investigated to develop a preventive or therapeutic vaccine, although none of them has been fully practical. Therapeutic vaccines against HIV-1 have been studied with the aim of eliminating the virus from reservoir cells with or without HAART (Highly Active Antiretroviral Therapy). Fusion proteins with the most immunogenic features among conserved regions can facilitate this achievement in such a variable virus. To achieve the most immunogenic and also conserved regions, bioinformatics tools are widely used to predict antigens’ features before applyin

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Abdallah, R. S., O. O. Banwo, R. H. Makundi, and J. C. Mbapila. "First Report of Dactylispa lenta Weise (Coleoptera: Chrysomelidae) as a Vector of Rice Yellow Mottle Virus." Acta Phytopathologica et Entomologica Hungarica 36, no. 1-2 (2001): 189–92. http://dx.doi.org/10.1556/aphyt.36.2001.1-2.22.

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