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Dissertations / Theses on the topic 'Lentiviruses'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Robertson, David L. "Recombination in primate lentiviruses." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336866.

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2

Vödrös, Dalma. "Receptor use of primate lentiviruses /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-497-6/.

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3

Bailes, Elizabeth. "Origins and evolution of primate lentiviruses." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246384.

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4

Kelly, Maureen C. "Parallels in tRNA primer acquisition by lentiviruses." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/kelly.pdf.

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5

Li, Li. "Short-term and long-term evolution of lentiviruses." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.575475.

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Lentiviruses have paradoxically fast short-term rate of evolution and slow long-term rate of evolution, which differ by several orders of magnitude. In this thesis, with a new method called truncated tree analysis, slower rates of evolution of transmitted viruses were estimated. However, the rate decline of the transmitted viruses is limited, and is not sufficient to explain the dramatic difference between the short-term and long-term evolutionary rates. These dramatically different rates were reconciled by an S shaped curve based on the new trend observed from this thesis. In the middle part

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6

Broughton-Neiswanger, Liam E. "Maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock a molecular epidemiology study /." Pullman, Wash. : Washington State University, 2010. http://www.dissertations.wsu.edu/Thesis/Spring2010/L_Broughton_042010.pdf.

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Thesis (M.S. in veterinary science)--Washington State University, May 2010.<br>Title from PDF title page (viewed on June 29, 2010). "College of Veterinary Medicine." Includes bibliographical references (p. 20-26).

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7

Stewart, Meredith Ellen. "An investigation into aspects of the replication of Jembrana disease virus /." Access via Murdoch University Digital Theses Project, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20051222.104106.

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8

Bichel, Katsiaryna. "Understanding post-entry pre-integration lentiviral biology." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648287.

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9

Harris, Matthew E. "Analysis of post-transcriptional regulation of lentiviruses and mammalian hepadnaviruses /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9935471.

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10

Ditcham, William. "The development of recombinant vaccines against Jembrana disease." Thesis, Ditcham, William (2007) The development of recombinant vaccines against Jembrana disease. PhD thesis, Murdoch University, 2007. https://researchrepository.murdoch.edu.au/id/eprint/438/.

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Jembrana disease virus (JDV) is a lentivirus causing an acute infection with a 17% case fatality rate in Bali cattle in Indonesia. Control of the disease is currently achieved by identification of infected areas and restriction of cattle movement. A detergent-inactivated whole virus tissue-derived vaccine is sometimes employed in affected areas. This thesis reports initial attempts to produce genetically engineered vaccines to replace the inactivated tissue-derived vaccine, which as it is made from homogenised spleen of infected animals, is expensive to produce and could contain adventitio

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11

Ditcham, William. "The development of recombinant vaccines against Jembrana disease." Ditcham, William (2007) The development of recombinant vaccines against Jembrana disease. PhD thesis, Murdoch University, 2007. http://researchrepository.murdoch.edu.au/438/.

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Jembrana disease virus (JDV) is a lentivirus causing an acute infection with a 17% case fatality rate in Bali cattle in Indonesia. Control of the disease is currently achieved by identification of infected areas and restriction of cattle movement. A detergent-inactivated whole virus tissue-derived vaccine is sometimes employed in affected areas. This thesis reports initial attempts to produce genetically engineered vaccines to replace the inactivated tissue-derived vaccine, which as it is made from homogenised spleen of infected animals, is expensive to produce and could contain adventitiou

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12

Feyertag, Felix. "Evolutionary dynamics of lentiviruses associated with drug resistance and host adaptation." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/evolutionary-dynamics-of-lentiviruses-associated-with-drug-resistance-and-host-adaptation(cf1aaffa-c1c2-450d-8d25-538c0bcc0d02).html.

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Studying evolutionary dynamics is crucial for epidemiological containment and/or eradication of viral diseases. With recent advancements in genetic sequencing, the spread of viruses can be monitored and sequenced almost in real-time as epidemics unfold, and sophisticated statistical analytical methods allow for the inference of population genetic and evolutionary characteristics directly from epidemiologic and genetic data. In this thesis, I have investigated various evolutionary aspects of the human immunodeficiency virus, the causative agent of AIDS, in the context of (a) within-host evoluti

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13

au, w. ditcham@murdoch edu, and William Ditcham. "The development of recombinant vaccines against Jembrana disease." Murdoch University, 2007. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20071119.94111.

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Jembrana disease virus (JDV) is a lentivirus causing an acute infection with a 17% case fatality rate in Bali cattle in Indonesia. Control of the disease is currently achieved by identification of infected areas and restriction of cattle movement. A detergent-inactivated whole virus tissue-derived vaccine is sometimes employed in affected areas. This thesis reports initial attempts to produce genetically engineered vaccines to replace the inactivated tissue-derived vaccine, which as it is made from homogenised spleen of infected animals, is expensive to produce and could contain adventitious

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14

Setiyaningsih, Surachmi. "Molecular and immunogenic analysis of Jembrana disease virus Tat." Thesis, Setiyaningsih, Surachmi (2006) Molecular and immunogenic analysis of Jembrana disease virus Tat. PhD thesis, Murdoch University, 2006. https://researchrepository.murdoch.edu.au/id/eprint/299/.

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Jembrana disease is an acute and severe disease of Bali cattle (Bos javanicus) endemic in Indonesia that is caused by a bovine lentivirus designated Jembrana disease virus (JDV). Previous studies have demonstrated that it is possible to induce a protective immunity against the disease by immunisation with a crude whole virus vaccine prepared from the tissues of infected cattle. This vaccine has been demonstrated to ameliorate the clinical signs of disease resulting from exposure to virus infection but a safer vaccine amenable to commercial production techniques is required. JDV, like all l

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15

Setiyaningsih, Surachmi. "Molecular and immunogenic analysis of Jembrana disease virus Tat." Setiyaningsih, Surachmi (2006) Molecular and immunogenic analysis of Jembrana disease virus Tat. PhD thesis, Murdoch University, 2006. http://researchrepository.murdoch.edu.au/299/.

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Jembrana disease is an acute and severe disease of Bali cattle (Bos javanicus) endemic in Indonesia that is caused by a bovine lentivirus designated Jembrana disease virus (JDV). Previous studies have demonstrated that it is possible to induce a protective immunity against the disease by immunisation with a crude whole virus vaccine prepared from the tissues of infected cattle. This vaccine has been demonstrated to ameliorate the clinical signs of disease resulting from exposure to virus infection but a safer vaccine amenable to commercial production techniques is required. JDV, like all l

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16

Carnell, George William. "Development of hybrid haemagglutinin pseudotyped lentiviruses to assess heterosubtypic immunity to influenza." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/66363/.

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The influenza virus still causes hundreds of thousands of deaths globally, on top of morbidity and associated economic burden. We are currently at the height of efforts surrounding the development and employment of 'universal' vaccines against this virus, with clinical trials commencing on the most promising candidates. Despite this, the influenza virus poses more of a threat to human life than it ever has previously, with multiple subtypes of pandemic potential circulating around the globe. The key to current efforts lies in the priming of the immune system towards generating long lasting def

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17

Stivahtis, Gina Lynn. "The role of Vpr in cell-cycle regulation by diverse primate lentiviruses /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/5017.

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18

Zhu, Xiaonan. "Identification of the Function of the Vpx Protein of Primate Lentiviruses: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/447.

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Primate lentiviruses encode four “accessory proteins” including Vif, Vpu, Nef, and Vpr/ Vpx. Vif and Vpu counteract the antiviral effects of cellular restrictions to early and late steps in the viral replication cycle. The functions of Vpx/ Vpr are not well understood. This study presents evidence that the Vpx proteins of HIV-2/ SIVSMpromote HIV-1 infection by antagonizing an antiviral restriction in myeloid cells. Fusion of macrophages in which Vpx was essential for virus infection, with COS cells in which Vpx was dispensable for virus infection, generated heterokaryons that supported infecti

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19

Price, Amanda Jane. "Host-pathogen interactions in lentiviral post-entry restriction and nuclear import." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609671.

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20

Tristem, Michael. "Sequence of a novel isolate of HIV-2 and its relationship to other lentiviruses." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239787.

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21

Pryszlak, Anna Marta [Verfasser], and Felix [Akademischer Betreuer] Hoppe‐Seyler. "Functional Crosstalk between Human Papillomaviruses and Lentiviruses / Anna Marta Pryszlak ; Betreuer: Felix Hoppe‐Seyler." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180607856/34.

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22

Cordeil, Stéphanie. "Etude de la différence de susceptibilité des lentivirus de primates aux interférons de type I." Thesis, Lyon, École normale supérieure, 2012. http://www.theses.fr/2012ENSL0781.

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Les IFN-I (interférons de type I), principalement IFN et , constituent un mécanisme de défense primordial de l’hôte contre les pathogènes. Pourtant, dans le cas du VIH-1 (virus de l’immunodéficience humaine), la relation entre les IFN-I et la réplication virale apparaît plus complexe. En effet, si les IFN-I inhibent la réplication du VIH-1 ex vivo, un état d’hyperactivation permanent de la réponse IFN-I a été récemment associé à la progression vers le SIDA ainsi qu’à une forte virémie chez les patients infectés par le VIH-1. De même, la dérégulation de la réponse IFN-I est un critère détermina

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23

Limberis, Maria. "A lentiviral gene transfer vector for the treatment of cystic fibrosis airway disease." Title page, synopsis and list of contents only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phl735.pdf.

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"16th September 2002." Accompanying CD contains 2 MPEG clips with accompanying text, and a copy in PDF format of: Recovery of airway cystic fibrosis transmembrane conductance regulator function in mice with cystic fibrosis after single-dose lentivirus-mediated gene transfer / M. Limberis ... [et al.], published in Human gene therapy vol. 13 (2002). Bibliography: leaves xxix-li. This thesis focuses on modulating the physical barriers of the airway epithelium with mild detergents, so as to enhance gene transfer by a HIV-1 based lentivirus vector in vivo. The efficiency of the gene transfer was

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24

Gelinas, Jean-Francois. "Enhancement of lentiviral vector production through alteration of virus-cell interactions." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:9921b8b4-e2b5-4eec-9efc-6036765c8d55.

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Gene therapy is the introduction or alteration of genetic material with the intention to treat disease. To support this aim, viruses have been modified, with elements linked to viral pathogenicity removed from their genome and replaced by the genetic material to be delivered. Gene therapy vectors based on lentiviruses have many advantages, such as the ability to transduce non-dividing cells and to target specific cell types via pseudotyping. They have been successfully used in ex vivo clinical trials for several haematopoietic stem cell disorders. Lentiviral vectors, however, suffer from subst

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25

Jung, Cindy. "Quantitative analysis of lentivirus incorporation of heterologous viral and non-viral proteins for lung gene therapy." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/26648.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Joseph M. Le Doux; Committee Member: AndrÃ©s J. Garcia; Committee Member: Cheng Zhu; Committee Member: Nael McCarty; Committee Member: Richard Compans. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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26

Legrand, Alexandre. "Evolutionary and functional characterization of SAMD9/SAMD9L innate immunity proteins and their involvement in HIV infection." Electronic Thesis or Diss., Lyon, École normale supérieure, 2024. http://www.theses.fr/2024ENSL0055.

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Le VIH, virus responsable de la pandémie de SIDA, trouve son origine dans des transmissions inter-espèces de lentivirus simiens. Comprendre les interactions moléculaires entre le VIH et la cellule hôte est un objectif majeur pour l’avancée de la lutte contre le VIH/SIDA. En particulier, l’identification de nouveaux acteurs de l’immunité innée contre le VIH participe à la compréhension de son adaptation à l’humain, mais aussi renseigne plus largement sur les stratégies antivirales employées par l’hôte. A cet égard, les gènes SAMD9 et SAMD9L apparaissent comme des candidats d’intérêt. Constituan

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27

Osejindu, Emma. "Investigation of the effects of virus integration on host gene expression in mouse tumour samples." Thesis, Brunel University, 2011. http://bura.brunel.ac.uk/handle/2438/6565.

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Clonally derived liver tumours and an ovarian cyst developed in mice following EIAV and FIV delivery in utero. LAM PCR and 454 sequencing was used to retrieve proviral insertion sites. TaqMan analysis revealed gene expression changes in lentiviral infected tumours. STRING and IPA networks identified links between genes flanking the lentivirus provirus and oncogenic pathways supporting the role of insertional mutagenesis in Hepatocellular Carcinoma (HCC). Global methylation analysis demonstrated increased relative methylation levels in lentivirus (EIAV, FIV, and HIV) infected normal and tumour

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28

Bell, Ian. "T-cell signalling dysfunction associated with expression of NEF derived from the primate lentiviruses, HIV-1 and SIV." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299904.

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29

Landázuri, Natalia. "Effects of flocculation on retrovirus processing, delivery and transduction." Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-04042005-120801/unrestricted/landazuri%5Fnatalia%5F200505%5Fphd.pdf.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2005.<br>Niren Murthy, Committee Member ; Andrš J. Garca̕, Committee Member ; Joseph M. Le Doux, Committee Chair ; Mark R. Prausnitz, Committee Member ; H. Trent Spencer, Committee Member. Includes bibliographical references.

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30

Martin, Michaël. "Mécanisme moléculaire de l'antagonisme du complexe HUSH par les protéines lentivirales Vpx et Vpr." Electronic Thesis or Diss., Université Paris Cité, 2021. http://www.theses.fr/2021UNIP5160.

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Les VIH-1 et VIH-2, lentivirus responsables du SIDA, sont issus de transmissions inter-espèces de virus simiens (SIV) à l'homme. Outre leurs protéines de structure et de régulation, les lentivirus codent pour des protéines auxiliaires qui favorisent la réplication virale dans la cellule hôte en contrecarrant des facteurs cellulaires antiviraux, appelés facteurs de restriction. Le mécanisme d'action de ces protéines virales auxiliaires repose souvent sur le détournement de complexes Ubiquitine-Ligases, un mécanisme très répandu chez une grande variété de pathogènes, en vue de dégrader des proté

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31

Pernot, Eileen. "Etude in vivo du rôle de la 5-phosphatase de phosphoinositides SKIP." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210473.

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Les membres de la famille des 5-phosphatases d’inositols polyphosphates et de phosphoinositides sont des enzymes caractérisées par la présence de deux domaines catalytiques conservés qui hydrolysent un phosphate en position 5 sur un noyau inositol. SKIP (Skeletal Muscle and Kidney enriched Inositol Phosphatase), également appelée Pps (Putative PI 5-phosphatase) est un des derniers membres de la famille des 5-phosphatases à avoir été découvert à ce jour. Cette enzyme hydrolyse majoritairement le phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) et le phosphatidylinositol-3,4,5-trisphosphate

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32

Vabret, Nicolas. "Hypothèses sur l'implication du biais nucléotidique des lentivirus dans le développement du SIDA et nouvelles stratégies d'atténuation du VIH-1." Thesis, Lyon, École normale supérieure, 2011. http://www.theses.fr/2011ENSL0649.

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Après 30 années de recherche, de nombreux obstacles s'opposent encore à la conception d'un vaccin contre le SIDA. En effet, il n'existe pas de consensus sur les corrélats immunitaires de protection qu'il devra induire ni sur les mécanismes à l'origine de la progression vers le SIDA chez les individus infectés. Dans un premier temps, nous avons cherché à concevoir un virus hybride structuralement semblable au VIH-1 et capable de se répliquer exclusivement dans le cytoplasme des cellules infectées. Dans cet objectif, nous avons développé des nouveaux vecteurs bi et tri-cistroniques dérivés du po

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33

Inacio, Mamede Joao Filipe. "Interactions de la capside de lentivirus de primates avec les facteurs cellulaires de l’hôte." Thesis, Montpellier 1, 2012. http://www.theses.fr/2012MON13524/document.

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Depuis la découverte du virus de l'Immunodéficience humaine, un lentivirus, comme agent pathogène responsable de l'épidémie du SIDA en 1983, beaucoup de progrès sur le sujet ont été réalisés. Il existe deux types de virus différents pouvant infecter l'Homme, le HIV-1 et le HIV-2. Ces deux virus se regroupent en différents groupes et sous-types qui témoignent d'une grande diversité inter et intra individus (notions de quasi-espèces). La découverte de lentivirus infectant naturellement au moins quarante-cinq espèces de primates en Afrique sub-saharienne, a permis un enrichissement des connaissan

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34

Baup, Delphine. "Identification de gènes préférentiellement exprimés par les cellules dendritiques et évaluation critique d'une approche de transgenèse lentivirale afin d'en étudier la fonction biologique in vivo." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210209.

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A chaque instant notre organisme est confronté à des agents pathogènes de nature très variable. Pourtant, malgré toutes les agressions rencontrées, il maintient une certaine intégrité. Cette dernière résulte de la mise en place d’un système de défense perfectionné, fruit de la collaboration étroite de diverses cellules :le système immunitaire. Parmi toutes les cellules qui le composent, les cellules dendritiques jouent un rôle prépondérant. Disséminées dans la plupart de nos organes et tissus, elles surveillent, en alerte du moindre danger. Elles orchestrent la réponse immune :elles sont capab

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35

Lee, Wei-Cheng. "Studies on lentivirus infection of macrophages." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/29845.

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Several aspects of the interaction of macrophages and maedi visna virus (MVV) were undertaken: viral replication, phenotype, phagocytosis and antigen presenting function of macrophages after MVV (EV1) infection. MVV replication in monocyte-derived-macrophages (MDM) showed viral budding sites both at cytoplasmic and vesicular membranes. In contrast, viral budding sites predominantly occurred at the cytoplasmic membrane of skin fibroblasts, whilst virus accumulated in vesicular lumens of MVV-infected alveolar macrophages (AM). Many intracytoplasmic type A (ICA) particles accumulated in the cytop

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36

Starling, Isabella. "Mechanisms and specificity of lentivirus neurotoxicity." Thesis, University of Edinburgh, 1998. http://webex.lib.ed.ac.uk/abstracts/starli01.pdf.

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37

Burkala, Evan Jon. "Investigations of the Australian bovine lentivirus." Thesis, Burkala, Evan Jon (2001) Investigations of the Australian bovine lentivirus. PhD thesis, Murdoch University, 2001. https://researchrepository.murdoch.edu.au/id/eprint/41607/.

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The bovine lentiviruses (BL), Bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV) are two relatively unknown lentiviruses that produce remarkably different disease syndromes. BIV typically causes a mild and transient lymphocytosis with associated lymphadenopathy in Bos taurus cattle with some suggested mild immune suppression. JDV, on the other hand, is an acutely pathogenic lentivirus causing marked leucopoenia with associated lymphadenopathy and splenomegaly and has an experimental mortality rate of approximately 20%. Recombinant antigens of both bovine lentivirus includ

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Camacho, Emely. "Optimization of Lentivirus Production for Cancer Therapy." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-164715.

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Vectors based on lentivirus backbones have revolutionized our ability to transfer genesinto many cell types. Lentiviral vectors integrate into the chromatin of target cells and do not transfer any viral genes causing vector replication. Both of these features arecommonly used in gene therapy and have been used clinically in individuals sufferingfrom cancer, infections and genetic diseases. It has been discovered that T-cells can be genetically modified to be used as effective weapons against cancer: therefore virus mustbe produced to deliver the gene of interest into the T-cells. In this proje

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39

Parker, Douglas George Anthony, and park0290@flinders edu au. "Lentivirus-mediated gene expression in corneal endothelium." Flinders University. Medicine, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081204.094431.

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Modulation of corneal transplant rejection using gene therapy shows promise in experimental models but the most appropriate vector for gene transfer is yet to be determined. The overarching aim of the thesis was to evaluate the potential of a lentiviral vector for use in human corneal transplantation. Specific aims were: (i) to assess the ability of an HIV-1-based lentiviral vector to mediate expression of the enhanced yellow fluorescent protein (eYFP), and a model secreted protein interleukin-10 (IL10), in ovine and human corneal endothelium; and (ii) to examine the influence of lentivirus-me

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40

MAZARIN, VERONIQUE. "Etude d'un gene precoce du lentivirus visna." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX22964.

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41

Vink, C. A. "A hybrid lentivirus-transposon vector for safer gene therapy." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19233/.

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Gene therapy vectors based on the HIV-1 lentivirus are an attractive option for clinical applications because they enter a broad range of target cells efficiently and deliver stable gene expression through integration into host chromosomes. However, lentiviral vectors are known to integrate preferentially within actively transcribing genes. Leukaemia-like expansions observed in gene therapy trials using gammaretroviral vectors and are thought to have been caused by disruption of host proto-oncogenes at or close to the vector integration site, and the safety of these vectors may be related to t

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42

Lerondelle, Catherine. "Les infections mammaires à lentivirus chez les petits ruminants." Lyon 1, 1992. http://www.theses.fr/1992LYO10210.

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La mammite a lentivirus se manifeste sous deux formes: une forme clinique aigue lors de la mise-bas puis une forme subclinique chronique, la plus frequente. Dans les deux cas, la production est diminuee, voire annulee et le lait reste d'aspect normal. La numeration cellulaire, un mois apres la mise-bas, est peu modifiee. Le virus est mis en evidence a partir des cellules du lait. Les lesions de mammite interstitielle sont observees meme chez les chevrettes de trois mois et les agnelles de 100 jours. Dans les explants de tissu mammaire, la presence du virus est suspectee dans les cellules epith

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Bodungen, Uta von. "Immunohistology of the early course of lentivirus-induced arthritis /." [S.l.] : [s.n.], 1996. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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44

He, Jin. "Lentiviral vectors mechanisms of transgene silencing and functional characterization of novel genes /." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0006628.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 143 pages. Includes Vita. Includes bibliographical references.

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45

Chettab, Abdelkamel. "Utilisation de constructions plasmidiques pour l'investigation des interactions entre les lentivirus des petits ruminants et leurs hôtes in vivo et in vitro." Lyon 1, 1997. http://www.theses.fr/1997LYO1T107.

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46

Rolland, Morgane. "Etude des relations phylogénétiques entre les lentivirus des petits ruminants." Bordeaux 2, 2003. http://www.theses.fr/2003BOR21029.

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Les lentivirus des petits ruminants ou SRLV ("small ruminant lentivirus") correspondent au virus mae͏̈di visna ou MVV, qui infecte les moutons, et au virus de l'arthrite-encéphalite caprine ou CAEV ("caprine arthritis-encephalitis Virus"), qui infecte les chèvres. Pour faciliter l'étude des SRLV, nous avons immortalisé des cellules GSM ("goat synovial membrane") par l'expression ectopique de la télomérase. La lignée cellulaire GSM T a proliféré à un rythme constant avec plus de 160 passages en culture, tout en conservaNt la morphologie des cellules GSM primaires. De plus, les cellules GSM T pe

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Gourdou, Isabelle. "Le lentivirus Visna : étude de ses gènes de régulation précoces." Aix-Marseille 1, 1990. http://www.theses.fr/1990AIX11291.

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Le cycle replicatif du virus visna in vitro comprend une phase precoce de 24 h, au cours de laquelle seuls les arnm sous-genomiques de 1,4 kb et 1,7 kb sont synthetises, et une phase tardive (qui s'acheve 3 jours apres l'infection) ou tous les arnm viraux sont presents. Cette regulation temporelle de l'expression virale est fonction de la presence, dans le genome proviral, de genes supplementaires par rapport aux trois genes de structure retroviraux gag, pol, env. Ainsi, les arnm precoces de 1,4 kb et 1,7 kb portent les genes additionnels tat et rev, dont les produits (tat et rev) trans-active

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Puissant, Bénédicte. "Etude de facteurs génétiques susceptibles d'influencer l'infection par les lentivirus." Toulouse 3, 2005. http://www.theses.fr/2005TOU30036.

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Chez l'homme et les primates, les facteurs génétiques de l'hôte influencent fortement la sévérité de l'immunodéficience provoquée par les lentivirus VIH humains ou SIV simiens. Notre étude du polymorphisme des gènes de chémokines et de leurs récepteurs chez l'homme révèle que ces gènes n'influencent peu ou pas l'évolution de la maladie traitée. Ces gènes sont polymorphes dans les huit espèces de primates que nous avons étudiées. En dehors des gènes de chémokines et de leurs récepteurs, nous avons étudié, chez l'homme, l'impact du polymorphisme des glycosyltranférases de groupes sanguins et déc

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Barban, Véronique. "Etude du contenu génétique et de l'expression des lentivirus animaux." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37595704k.

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Ahmid, Simaa. "Analyse fonctionnelle de génomes lentiviraux de primates réplicatifs sous le contrôle des promoteurs du lentivirus caprin CAEV : Modèle d'étude pour la latence et persistance des lentivirus." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV018/document.

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Le syndrome d'immunodéficience acquise (SIDA) est une maladie provoquée chez l'homme par le virus de l'immunodéficience humaine (VIH), un lentivirus à ARN monocaténaire qui infecte les cellules humaines qui expriment les CD4 à leur surface. Depuis son apparition en 1982 chez l’homme, il y a eu environ 80 millions d'individus infectés dans le monde et près de la moitié d'entre eux sont déjà décédés. Aucun vaccin n'existe actuellement mais l'espérance de vie d’un grand nombre de patients est maintenant prolongée grâce au développement et la disponibilité d'un traitement antirétroviral hautement

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