Relevant bibliographies by topics / Leptospira

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Leptospira'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Leptospira"

1

Masuzawa, Toshiyuki, Yuji Hashiguchi, Ryuta Nakamura, et al. "Experimental lethal infection of Leptospira interrogans in mice treated with cyclophosphamide." Canadian Journal of Microbiology 37, no. 4 (1991): 312–15. http://dx.doi.org/10.1139/m91-048.

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After preadministration of cyclophosphamide (300 mg/kg), BALB/c mice were lethally infected with Leptospira interrogans serovar lai and a virulent strain of Leptospira interrogans serovar copenhageni, and leptospiral cells were detected in both kidneys of infected mice by indirect immunofluorescent assay. Nonpathogenic leptospirae, Leptospira biflexa serovar patoc, Leptonema illini, and an avirulent strain of L. interrogans serovar copenhageni, were not parasitic to the mice treated with cyclophosphamide. The cyclophosphamide-treated mice were protected from the homologous leptospiral infectio
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Díaz, M. Mónica, Eduardo Gotuzzo, Kalina J. Campos, et al. "DIVERSITY OF BAT-ASSOCIATED LEPTOSPIRA IN THE PERUVIAN AMAZON INFERRED BY BAYESIAN PHYLOGENETIC ANALYSIS OF 16S RIBOSOMAL DNA SEQUENCES." American Journal of Tropical Medicine and Hygiene 73, no. 5 (2005): 964–74. https://doi.org/10.5281/zenodo.13446735.

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(Uploaded by Plazi for the Bat Literature Project) The role of bats as potential sources of transmission to humans or as maintenance hosts of leptospires is poorly understood. We quantified the prevalence of leptospiral colonization in bats in the Peruvian Amazon in the vicinity of Iquitos, an area of high biologic diversity. Of 589 analyzed bats, culture (3 of 589) and molecular evidence (20 of 589) of leptospiral colonization was found in the kidneys, yielding an overall colonization rate of 3.4%. Infection rates differed with habitat and location, and among different bat species. Bayesian a
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Díaz, M. Mónica, Eduardo Gotuzzo, Kalina J. Campos, et al. "DIVERSITY OF BAT-ASSOCIATED LEPTOSPIRA IN THE PERUVIAN AMAZON INFERRED BY BAYESIAN PHYLOGENETIC ANALYSIS OF 16S RIBOSOMAL DNA SEQUENCES." American Journal of Tropical Medicine and Hygiene 73, no. 5 (2005): 964–74. https://doi.org/10.5281/zenodo.13446735.

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(Uploaded by Plazi for the Bat Literature Project) The role of bats as potential sources of transmission to humans or as maintenance hosts of leptospires is poorly understood. We quantified the prevalence of leptospiral colonization in bats in the Peruvian Amazon in the vicinity of Iquitos, an area of high biologic diversity. Of 589 analyzed bats, culture (3 of 589) and molecular evidence (20 of 589) of leptospiral colonization was found in the kidneys, yielding an overall colonization rate of 3.4%. Infection rates differed with habitat and location, and among different bat species. Bayesian a
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Díaz, M. Mónica, Eduardo Gotuzzo, Kalina J. Campos, et al. "DIVERSITY OF BAT-ASSOCIATED LEPTOSPIRA IN THE PERUVIAN AMAZON INFERRED BY BAYESIAN PHYLOGENETIC ANALYSIS OF 16S RIBOSOMAL DNA SEQUENCES." American Journal of Tropical Medicine and Hygiene 73, no. 5 (2005): 964–74. https://doi.org/10.5281/zenodo.13446735.

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(Uploaded by Plazi for the Bat Literature Project) The role of bats as potential sources of transmission to humans or as maintenance hosts of leptospires is poorly understood. We quantified the prevalence of leptospiral colonization in bats in the Peruvian Amazon in the vicinity of Iquitos, an area of high biologic diversity. Of 589 analyzed bats, culture (3 of 589) and molecular evidence (20 of 589) of leptospiral colonization was found in the kidneys, yielding an overall colonization rate of 3.4%. Infection rates differed with habitat and location, and among different bat species. Bayesian a
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Díaz, M. Mónica, Eduardo Gotuzzo, Kalina J. Campos, et al. "DIVERSITY OF BAT-ASSOCIATED LEPTOSPIRA IN THE PERUVIAN AMAZON INFERRED BY BAYESIAN PHYLOGENETIC ANALYSIS OF 16S RIBOSOMAL DNA SEQUENCES." American Journal of Tropical Medicine and Hygiene 73, no. 5 (2005): 964–74. https://doi.org/10.5281/zenodo.13446735.

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(Uploaded by Plazi for the Bat Literature Project) The role of bats as potential sources of transmission to humans or as maintenance hosts of leptospires is poorly understood. We quantified the prevalence of leptospiral colonization in bats in the Peruvian Amazon in the vicinity of Iquitos, an area of high biologic diversity. Of 589 analyzed bats, culture (3 of 589) and molecular evidence (20 of 589) of leptospiral colonization was found in the kidneys, yielding an overall colonization rate of 3.4%. Infection rates differed with habitat and location, and among different bat species. Bayesian a
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Díaz, M. Mónica, Eduardo Gotuzzo, Kalina J. Campos, et al. "DIVERSITY OF BAT-ASSOCIATED LEPTOSPIRA IN THE PERUVIAN AMAZON INFERRED BY BAYESIAN PHYLOGENETIC ANALYSIS OF 16S RIBOSOMAL DNA SEQUENCES." American Journal of Tropical Medicine and Hygiene 73, no. 5 (2005): 964–74. https://doi.org/10.5281/zenodo.13446735.

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(Uploaded by Plazi for the Bat Literature Project) The role of bats as potential sources of transmission to humans or as maintenance hosts of leptospires is poorly understood. We quantified the prevalence of leptospiral colonization in bats in the Peruvian Amazon in the vicinity of Iquitos, an area of high biologic diversity. Of 589 analyzed bats, culture (3 of 589) and molecular evidence (20 of 589) of leptospiral colonization was found in the kidneys, yielding an overall colonization rate of 3.4%. Infection rates differed with habitat and location, and among different bat species. Bayesian a
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Zhao, Wei, Chun-Yan Chen, Xiang-Yan Zhang, et al. "Molecular characterization of the pL40 protein inLeptospira interrogans." Canadian Journal of Microbiology 55, no. 6 (2009): 739–49. http://dx.doi.org/10.1139/w09-014.

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Leptospirosis is a widespread zoonotic disease caused by pathogenic leptospires. The identification of outer membrane proteins (OMPs) conserved among pathogenic leptospires, which are exposed on the leptospiral surface and expressed during mammalian infection, has become a major focus of leptospirosis research. pL40, a 40 kDa protein coded by the LA3744 gene in Leptospira interrogans , was found to be unique to Leptospira . Triton X-114 fractionation and flow cytometry analyses indicate that pL40 is a component of the leptospiral outer membrane. The conservation of pL40 among Leptospira strain
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LI, S. J., D. M. WANG, C. C. ZHANG, et al. "Molecular typing of Leptospira spp. strains isolated from field mice confirms a link to human leptospirosis." Epidemiology and Infection 141, no. 11 (2013): 2278–85. http://dx.doi.org/10.1017/s0950268813000216.

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SUMMARYIn recent years, human leptospirosis has been reported in Jinping and Liping counties, Guizhou province, but the leptospires have never been isolated. To track the source of infection and understand the aetiological characteristics, we performed surveillance for field mice carriage of leptospirosis in 2011. Four strains of leptospire were isolated from Apodemus agrarius. PCR confirmed the four isolates as pathogenic. Multiple-locus variable-number tandem repeat analysis (MLVA) showed that the four strains were closely related to serovar Lai strain 56601 belonging to serogroup Icterohaem
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Doungchawee, Galayanee, Worachart Sirawaraporn, Albert Icksang-Ko, Suraphol Kongtim, Pimjai Naigowit, and Visith Thongboonkerd. "Use of immunoblotting as an alternative method for serogrouping Leptospira." Journal of Medical Microbiology 56, no. 5 (2007): 587–92. http://dx.doi.org/10.1099/jmm.0.47143-0.

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Leptospirosis is a worldwide zoonotic disease caused by a spirochaete bacterium, Leptospira. Serological detection of this micro-organism basically relies on a conventional microscopic agglutination test (MAT), which has some limitations and disadvantages. In the present study, immunoblotting has been applied as an alternative method for differentiating serogroups and serovars of leptospires. Leptospiral whole-cell lysates from a total of 26 serovars were subjected to immunoblotting using rabbit antisera against individual serovars. The findings clearly demonstrated that the pattern of immunor
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Rahmani, Zahra, Pejvak Khaki, Mehdi Gharakhani, and Majid Esmaelizad. "Molecular Detection of lsa21 Gene Encoding an Adhesion Protein Among Pathogenic Leptospiral Serovars." International Journal of Enteric Pathogens 11, no. 2 (2023): 46–50. http://dx.doi.org/10.34172/ijep.5586.

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Background: Leptospirosis, as an emerging global public health problem, is a widespread zoonosis and substantial infectious disease caused by pathogenic Leptospira spp. The diagnosis of the disease remains a challenge due to its non-specific clinical symptoms. The Lsa21 protein is one of the leptospiral proteins that has extracellular matrix-binding properties that are expressed during the infection of pathogenic Leptospira serovars. Objectives: The study aimed to assess the presence of the lsa21 gene in Leptospira serovars. Materials and Methods: The study was conducted on 22 pathogenic Lepto
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Dissertations / Theses on the topic "Leptospira"

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Truccolo, Johann. "Virulence des Leptospira : aspects physiopathologiques et thérapeutiques." Paris 6, 2002. http://www.theses.fr/2002PA066358.

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Matos, Vanessa Ramos. "Caracterização funcional de uma provável colagenase de Leptospira interrogans sorovar Copenhageni." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22042015-170400/.

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A leptospirose é uma zoonose, amplamente difundida pelo mundo, causada por espiroquetas patogênicas do gênero Leptospira, que colonizam os túbulos renais de animais silvestres e domésticos. A transmissão ocorre, principalmente, pelo contato direto com água e solo contaminados com a urina de animais infectados que podem ser clinicamente assintomáticos. As leptospiras patogênicas invadem os tecidos do hospedeiro através da penetração da pele lesada ou mucosas da boca, narina e olhos. Logo após ultrapassar as superfícies de contato, as bactérias chegam rapidamente à corrente sanguínea e espalham
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Herrmann, Geder Paulo. "Leptospira sp em ovinos do Rio Grande do Sul soroprevalência e avaliação da imunogenicidade da bacterina leptospira hardjo." Universidade Federal de Minas Gerais, 2002. http://hdl.handle.net/1843/BUOS-8C7HDA.

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We determined the seroprevalence of anti-Leptospira sp aglunininas in 1360 serum samples from sheep, the Southeast and Southwest messorregiãoes Rio Grande, between the months January to March of 199. The highest seroprevalence of Leptospira sp, more frequently to serovar hardjo, we elaborated a monovalent L hardjo, as oil adjuvant, administered to two groups of sheep consisting of 15 sheep and a third consisting of 10 control animals. The first group received two doses of vaccine with an interval of 30 days and the second group only one dose of vaccine by the microscopic agglutination test and
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Zilber, Anne-Laure. "Rôle du rat brun (Rattus norvegicus) dans la persistance des leptospires en conditions naturelles." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10243/document.

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La leptospirose est une zoonose ré-émergente de distribution mondiale, causée par un spirochète du genre Leptospira. L'OMS rapporte environ un million de cas sévères de leptospirose humaine par an à travers le monde, avec un taux de mortalité de 10 %. Les rongeurs étant considérés comme les principaux hôtes réservoirs de cette bactérie, la transmettent aux Hommes et aux animaux, par un contact direct ou indirect via de l'urine infectée. Le rat brun (Rattus norvegicus) est important d'un point de vue épidémiologique car il est réservoir du principal sérogroupe incriminé dans les cas de leptospi
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Thaipadungpanit, Janjira. "Multilocus Sequence Typing of the Genus Leptospira." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495577.

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Epidemiological studies in rural Thailand have demonstrated that leptospirosis is a major cause of acute febrile illness in this setting. Superimposed on this was a sustained outbreak in northeast Thailand between 1999-2003, the basis for which was unknown. Outbreaks elsewhere in the world are commonly associated with the presence of a dominant, region-specific serovar of Leptospira, and it was postulated here that the Thai outbreak was due to the emergence of a single biologically successful clone. An inherent weakness in defining the population genetic structure of Leptospira is that the com
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Perolat, Philippe. "Typage moléculaire et taxonomie des Leptospira pathogènes." Paris 11, 1993. http://www.theses.fr/1993PA114834.

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Ricaldi, Camahuali Jessica Nancy. "Genomic insights into the pathogenesis of Leptospira." Diss., [La Jolla, Calif.] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3356365.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed July 9, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 124-143).
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Moseley, Mark. "The diversity and ecology of Leptospira in Madagascar." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=236422.

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Multi-host pathogens include some of the most important pathogens of humans and livestock and, due to their complex biology, are particularly difficult to control. Leptospirosis is one of the most common, but neglected, zoonotic diseases in the world and an important cause of production losses in livestock. In Madagascar, potentially pathogenic Leptospira have been identified in both invasive and endemic small mammal hosts with strict associations noted between Leptospira species and host genera. However, in other regions, it is understood that Leptospira can infect multiple hosts and that liv
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Silva, Lucas Pereira e. "Clonagem, expressão e caracterização de prováveis proteínas de membrana indentificadas no genoma de Leptospira interrogans." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-24082016-094832/.

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A leptospirose é uma doença sistêmica, causada por bactérias patogênicas do gênero Leptospira. O desenvolvimento de novas estratégias para prevenir a doença é necessário. As pesquisas atuais têm interesse em identificar antígenos conservados que estão envolvidos nas interações patógeno-hospedeiro. Dois genes de L. interrogans foram selecionados, clonados, expressos e suas respectivas proteínas caracterizadas. Os genes foram amplificados por PCR e clonados no vetor de expressão PAE. As proteínas recombinantes foram purificadas por cromatografia de afinidade ao metal. A proteína rLIC10821 foi ca
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Fazolo, Demétria Luci. "Estudo da interação de prováveis lipoproteínas de membrana externa de Leptospira com proteínas do hospedeiro." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06122014-085815/.

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A leptospirose é uma zoonose mundial causada por espiroquetas patogênicas do gênero Leptospira, que colonizam os túbulos renais de animais domésticos e silvestres e são liberadas ao ambiente externo pela urina. Neste estudo avaliou-se a interação de seis prováveis lipoproteínas de membrana externa de leptospira com as proteínas do hospedeiro: colágeno I, colágeno IV, elastina, fibrinogênio, fibronectina celular e plasmática, laminina e plasminogênio. Os experimentos de adesão demonstraram que as proteínas recombinantes Lp21, Lp22 e Lsa30 apresentaram interação com os componentes do hospedeiro
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Books on the topic "Leptospira"

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Koizumi, Nobuo, and Mathieu Picardeau, eds. Leptospira spp. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0459-5.

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Adler, Ben, ed. Leptospira and Leptospirosis. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45059-8.

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M, Myers Donald, Pan American Zoonoses Center, and Pan American Zoonoses Center, eds. Manual of laboratory methods for the diagnosis of leptospirosis. Pan American Health Organization, 1985.

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Ašmera, Jaroslav. Problematika leptospiróz na severní Moravě. Státní pedagogické nakl., 1991.

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Mohamed Abdel Razek Mohamed Abdel Hafiz. Studies on detection of leptospira and Brucella antibodies in imported frozen meat and live slaughter cattle: Untersuchungen zum Nachweis von Leptospiren- und Brucellenantikorpern in Importsendungen von Gefrierfleisch und lebendem Schlachtvieh. Muhammad Ali Society, 1985.

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Ireland. Food Safety Advisory Committee. Leptospiral infections, Lyme disease, Babesiosis, Orf virus disease. Stationery Office, 1992.

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Meier-Winn, Andreas. Serologische Untersuchungen über das Vorkommen von leptospiren-Antikörpern bei Rindern im Saarland. [s.n.], 1986.

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Leptospira and leptospirosis. 2nd ed. MediSci, 1999.

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Wunder Jr, Elsio A., Azad Eshghi, and Nadia Benaroudj, eds. Pathogenesis of Leptospira. Frontiers Media SA, 2018. http://dx.doi.org/10.3389/978-2-88945-649-9.

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Adler, Ben. Leptospira and Leptospirosis. Springer Berlin / Heidelberg, 2016.

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Book chapters on the topic "Leptospira"

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Adler, B., and A. de la Peña Moctezuma. "Leptospira." In Pathogenesis of Bacterial Infections in Animals. Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9780470958209.ch28.

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Sagar, Tanu, Nitin Gupta, and Rama Chaudhry. "Leptospira." In Handbook of Foodborne Diseases. CRC Press, 2018. http://dx.doi.org/10.1201/b22030-34.

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Levett, Paul N. "Leptospira." In Manual of Clinical Microbiology. ASM Press, 2015. http://dx.doi.org/10.1128/9781555817381.ch58.

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Girons, Isabelle Saint, and Richard L. Zuerner. "Leptospira interrogans." In Bacterial Genomes. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-6369-3_65.

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Coia, John, and Heather Cubie. "Leptospira species." In The Immunoassay Kit Directory. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-009-0359-3_23.

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Levett, P. N. "Leptospira spp." In Principles and Practice of Clinical Bacteriology. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/9780470017968.ch39.

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Lydyard, Peter M., Michael F. Cole, John Holton, et al. "Leptospira spp." In Case Studies in Infectious Disease, 2nd ed. CRC Press, 2023. http://dx.doi.org/10.1201/9781003155447-21.

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Birtles, Richard. "Leptospira Infections." In Infectious Diseases of Wild Mammals and Birds in Europe. Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118342442.ch33.

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Foley, Janet, and Mary H. Straub. "Leptospira spp." In Interpretation of Equine Laboratory Diagnostics. John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781118922798.ch36.

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Johnson, Douglas I. "Leptospira spp." In Bacterial Pathogens and Their Virulence Factors. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-67651-7_21.

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Conference papers on the topic "Leptospira"

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Shatar, Liyana, Fatin H. Mustafa, and Fariza H. Suhailin. "Surface Enhanced Raman Scattering (SERS) Spectroscopy for Leptospira DNA Detection." In 2024 IEEE 10th International Conference on Photonics (ICP). IEEE, 2024. https://doi.org/10.1109/icp60542.2024.10877097.

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Veríssimo, Graciete Soares Libório, Ivanize Barbosa De Souza Almeida, and Paula Carvalhal Lage Von Buettner Ristow. "O PAPEL DA FORMAÇÃO DE BIOFILME EM LEPTOSPIRA: PROTEÇÃO DA AGRESSÃO DO MEIO AMBIENTE E INVASÃO E EVASÃO DO HOSPEDEIRO." In I Congresso Nacional de Microbiologia Clínica On-Line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1193.

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Introdução: Leptospiras são bactérias Gram-negativas, capazes de sobreviver no solo e na água por longos períodos. O gênero Leptospira é classificado em espécies saprofíticas e patogênicas. Leptospira patogênica causam leptospirose, zoonose com incidência global com mais de um milhão de casos e 58.900 mortes anual em todo o mundo. A leptospirose é transmitida através de solo ou água contaminada, pela urina do Rattus norvegicus, principal hospedeiro, que eliminam leptospiras viáveis no ambiente. Leptospira patogênicas podem infectar qualquer mamífero, inclusive o ser humano. In vitro e em ambie
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Silva, Letícia da, TAMIRIS SILVA LOPES, and BRENDA PICOLI GHENO. "INFECÇÃO POR LEPTOSPIRA SPP. EM GATOS." In I Congresso Brasileiro On-line One Health. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/i-onehealth/9418.

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Centeno, Jenette C., Jennifer C. Dela Cruz, Jayson T. Puerta, et al. "Leptospira Bacteria Detection using Digital Image Processing." In 2022 IEEE 14th International Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment, and Management (HNICEM). IEEE, 2022. http://dx.doi.org/10.1109/hnicem57413.2022.10109570.

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Dershowitz, L., J. Ross, J. Arace, S. D'Souza, and K. Melville. "Trick or Spirochete: Leptospira Infection With Negative Serology." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2433.

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Sumarningsih, Sumarningsih, and Simson Tarigan. "Preliminary Study: Characterisation of Antibody for rLipl32 Protein of Leptospira." In Proceedings of International Seminar on Livestock Production and Veterinary Technology. Indonesian Center for Animal Research and Development (ICARD), 2016. http://dx.doi.org/10.14334/proc.intsem.lpvt-2016-p.147-152.

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Amarasinghe, A. A. D. S., K. Abeysinghe, D. G. N. M. Abeywardana, S. R. Amarathunga, H. A. Anthonies, and J. Perera. "Knowledge, attitude, practice and their association on prevention of leptospirosis among adult paddy cultivating farmers in Bulathsinhala MOH area." In Annual Academic Sessions-2024. Faculty of Medicine, University of Moratuwa, 2024. https://doi.org/10.31705/fomaas.2024.16.

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Leptospirosis is an emerging zoonotic disease in Sri Lanka, caused by the Leptospira bacteria. It has a major global burden with high morbidity and mortality rates. Leptospirosis is a prevalent disease in Sri Lanka with recurrent seasonal outbreaks. The disease is primarily caused by occupational exposure. Prevention relies on good knowledge, positive attitudes towards prevention, and responsible practices.
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"Impedimetric Sensor of Leptospira Bacteria Based on Mixed Metal Alloys - Polyaniline Films." In March 14-16, 2019 Paris (France). Eminent Association of Pioneers, 2019. http://dx.doi.org/10.17758/eares5.eap0319206.

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RIBEIRO, P. H., B. D. S. LEITE, L. P. DA SILVA, et al. "DETECÇÃO MOLECULAR DE LEPTOSPIRA SPP. EM JAVALIS (SUS SCROFA) DE VIDA LIVRE." In XII ENCONTRO DE PÓS-GRADUAÇÃO DA FACULDADE DE MEDICINA DE BOTUCATU. Editora Omnis Scientia, 2024. http://dx.doi.org/10.47094/978-65-6036-515-5/35.

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10

Schmitt, K., M. Bergmann, and K. Hartmann. "Vergleich verschiedener Leptospira-spp.-Antikörper-Schnelltests bei gesunden Hunden nach Impfung gegen Leptospirose." In DVG. Georg Thieme Verlag, 2024. http://dx.doi.org/10.1055/s-0044-1779647.

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Reports on the topic "Leptospira"

1

Patarakul, Kanitha, and Yong Poovoravan. Study of homology of mce and invA genes among different serovars of Leptospira interrogans and their in vivo expression. Faculty of Medicine, Chulalongkorn University, 2010. https://doi.org/10.58837/chula.res.2010.13.

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Leptospirosis is a worldwide zoonotic disease. Pathogenesis of leptospirosis is not well understood. Identification of virulence factors of pathogenic Leptospira and their roles in pathogenesis is crucial. Based on available whole-genome sequences of Leptospira, two presumptive virulence genes which are homologous to the invasionA (invA) gene of Rickettsia prowazekii and the mammalian cell entry (mce) gene of Mycobacterium tuberculosis, have been identified. The function of these genes may involve in the attachment and invasion of eukaryotic cells. We proposed that these gene homologues should
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2

Chirthaworn, Chintana, Kanitha Patarakul, Duangporn Phulsuksombati, and Yong Pooworawan. Study of pathology and pathogenesis of leptospirosis in an animal model inoculated with various in vivo passages of leptospires : implications for vaccine development and diagnosis. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.26.

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Leptospirosis is a worldwide zoonosis caused by bacteria from the genus leptospira. Several reports have suggested the roles of cytokines in pathogenesis of this infectious disease. In this study, cytokine gene expression in kidneys livers and lung was investigated. In addition to host cytokine gene expression, the expression of leptospira genes at target organs was also studied. Golden Syrian hamsters were injected with virulent or avirulent leptospira interrogans serovar pyrogenes. Kidney liver and lung tissues were collected for pathological examination and gene expression. RNA was extracte
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3

Cardenas Solano, Leidy Johanna, and Carlos Alberto Contreras Pedraza. Vigilancia científica sobre desarrollo de vacunas contra Leptospira spp. Corporación colombiana de investigación agropecuaria - AGROSAVIA, 2025. https://doi.org/10.21930/agrosavia.vigilanciacientifica.2025.4.

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El presente estudio tiene como objetivo ofrecer un análisis actualizado de los principales avances en el desarrollo de vacunas y herramientas diagnósticas para la leptospirosis. Para ello, se realizó una revisión sistemática apoyada en el análisis de indicadores bibliométricos y cienciométricos que permiten identificar patrones de 7 Perspectivas científicas del agro Vigilancia científica sobre desarrollo de vacunas contra Leptospira spp. publicación, redes de colaboración, tópicos emergentes y áreas de alta productividad científica. La estrategia metodológica incluyó la consulta estructurada d
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4

ภัทรกุล, กนิษฐา, ไตรรักษ์ พิสิษฐ์กุล, นพดล แสงจันทร์ та Jacquet, Alain. การค้นหาวัคซีนแอนติเจนตัวใหม่ของโรคเลปโตสไปโรซิสโดยอาศัยโปรตีโอมิกส์ของโปรตีนบนผิวเซลล์. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2018. https://doi.org/10.58837/chula.res.2018.37.

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โรคเลปโตสไปโรซิสเป็นโรคที่มีการแพร่กระจายในหลายพื้นที่รวมทั้งประเทศไทย มีสาเหตุมาจากเชื้อเลปโตสไปราสายพันธุ์ก่อโรค ซึ่งพยาธิกำเนิดของโรคยังไม่ทราบชัดเจน โปรตีนบนผิวเซลล์เป็นส่วนแรกที่เชื้อสัมผัสกับเซลล์ของโฮสต์และสามารถกระตุ้นระบบภูมิคุ้มกัน จึงเป็นเป้าหมายสำคัญในการพัฒนาวัคซีน การหาโปรตีนบนผิวเซลล์ทั้งหมดจะเป็นข้อมูลสำคัญสำหรับการศึกษาพยาธิกำเนิด และการค้นหาวัคซีนตัวใหม่ งานวิจัยนี้มีจุดมุ่งหมายเพื่อจำแนกโปรตีนบนผิวเซลล์ทั้งหมดของเชื้อเลปโตสไปราสายพันธุ์ก่อโรค Leptospira interrogans serovar Pomona ในการศึกษานี้ใช้ 2 วิธี ในการคัดแยกโปรตีนบนผิวเซลล์ออกจากโปรตีนอื่น ได้แก่ วิธีการย่อยโปรตีนบนผิ
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Rodriguez Cortés, Jessica María. nnovaciones Biotecnológicas en Salud Animal y Agricultura: De la Detección de Enfermedades a la Gestión de Plagas. Sello Editorial UNAD, 2025. https://doi.org/10.22490/ecisa.9279.

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Este documento explora cómo las innovaciones biotecnológicas aplicadas a la salud animal y la agricultura están transformando la detección y el control de enfermedades y plagas. Se abordan investigaciones que incluyen la detección de anticuerpos contra Borrelia burgdorferi en caninos, la determinación de la seropositividad de Brucella abortus en ganado, la estabilidad genética en cepas de Leptospira y el uso del ARN de interferencia para el silenciamiento génico en insectos plaga. La aplicación de estas tecnologías permite una vigilancia más precisa y métodos sostenibles que benefician tanto a
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Patarakul, Kanitha, Chintana Chirathaworn, and Yong Poovorawan. Study of homology of mce and invA genes among different serovars of Leptospira interrogans and their in vivo expression as a step of vaccine development for leptospirosis. Chulalongkorn University, 2005. https://doi.org/10.58837/chula.res.2005.18.

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