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Relevant bibliographies by topics / Let-7c

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Conference papers

Academic literature on the topic 'Let-7c'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Let-7c"

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Shao, Liying, Ranran Wang, Yunxiao Sun, et al. "Delivery of MicroRNA-let-7c-5p by Biodegradable Silica Nanoparticles Suppresses Human Cervical Carcinoma Cell Proliferation and Migration." Journal of Biomedical Nanotechnology 16, no. 11 (2020): 1600–1611. http://dx.doi.org/10.1166/jbn.2020.2989.

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Human cervical cancer is the most common gynecological malignancy. The continuous development of nanotechnology has allowed the wide use of nanomaterials in cancer treatment. Nanoparticles can be used as gene carriers because of their surface effect and small-size effect. MicroRNA-let-7c-5p (miR-let-7c-5p) belongs to the let-7 family. Although it has been reported to exert a tumor suppressive effect in a variety of cancers, the exact role and mechanism of miR-let-7c-5p in the progression of cervical cancer are unclear. In this study, we synthesized flower-shaped SiO2 –PEI nanoparticles with hi

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Zhou, Zihui, Yuanshan Lu, Yao Wang, Lin Du, Yunpeng Zhang, and Jie Tao. "Let-7c regulates proliferation and osteodifferentiation of human adipose-derived mesenchymal stem cells under oxidative stress by targeting SCD-1." American Journal of Physiology-Cell Physiology 316, no. 1 (2019): C57—C69. http://dx.doi.org/10.1152/ajpcell.00211.2018.

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Osteoporosis is a progressive bone disease characterized by decreased bone mass and density, which usually parallels a reduced antioxidative capacity and increased reactive oxygen species formation. Adipose-derived mesenchymal stem cells (ADMSCs), a population of self-renewing multipotent cells, are a well-recognized source of potential bone precursors with significant clinical potential for tissue regeneration. We previously showed that overexpressing stearoyl-CoA desaturase 1 (SCD-1) promotes osteogenic differentiation of mesenchymal stem cells. Micro-RNAs (miRNAs) are noncoding RNAs recentl

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Narumanchi, Suneeta, Karri Kalervo, Sanni Perttunen, et al. "Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish." Journal of Cardiovascular Development and Disease 6, no. 2 (2019): 16. http://dx.doi.org/10.3390/jcdd6020016.

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The let-7c family of micro-RNAs (miRNAs) is expressed during embryonic development and plays an important role in cell differentiation. We have investigated the role of let-7c in heart regeneration after injury in adult zebrafish. let-7c antagomir or scramble injections were given at one day after cryoinjury (1 dpi). Tissue samples were collected at 7 dpi, 14 dpi and 28 dpi and cardiac function was assessed before cryoinjury, 1 dpi, 7 dpi, 14 dpi and 28 dpi. Inhibition of let-7c increased the rate of fibrinolysis, increased the number of proliferating cell nuclear antigen (PCNA) positive cardi

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Li, Ting, Yanhong Huang, Wenkai Zhou, and Qichang Yan. "Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells." BioMed Research International 2020 (March 16, 2020): 1–9. http://dx.doi.org/10.1155/2020/6069390.

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Background. Oxidative stress is an important factor during age-related cataract formation. Apoptosis and autophagy induced by oxidative stress have been reported as key factors in age-related cataract. In our research, we investigated the role of let-7c-3p in the regulation of autophagy and apoptosis during the formation of age-related cataract. Material and Methods. Real-time PCR and western blot were employed to detect the expression of let-7c-3p in the tissues of age-related cataract. Human lens epithelial cells (LECs) were treated with H2O2 as an age-related cataract model. The extent of a

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Wang, Zhenguo, Cuixing Zhou, Yangyang Sun, Yimeng Chen та Dong Xue. "Let-7c-5p Is Involved in Chronic Kidney Disease by Targeting TGF-β Signaling". BioMed Research International 2020 (13 червня 2020): 1–8. http://dx.doi.org/10.1155/2020/6960941.

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The purpose of the present study was to investigate the expressions of hsa-let-7c-5p and TGF-β signaling-related molecules and their correlations with clinical characteristics in chronic kidney disease (CKD). Twenty-three biopsy specimens of CKD patients and 20 negative control tissues were selected. Quantitative real-time PCR (qPCR) was used for the detection of hsa-let-7c-5p, transforming growth factor β (TGF-β) and TGF-β receptor type 1 (TGF-βR1) expression levels. Target gene of hsa-let-7c-5p was verified by dual-luciferase reporter assay. A significant decrease of hsa-let-7c-5p expression

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Shah, Yatrik M., Keiichirou Morimura, Qian Yang, Tomotaka Tanabe, Mitsuhiro Takagi та Frank J. Gonzalez. "Peroxisome Proliferator-Activated Receptor α Regulates a MicroRNA-Mediated Signaling Cascade Responsible for Hepatocellular Proliferation". Molecular and Cellular Biology 27, № 12 (2007): 4238–47. http://dx.doi.org/10.1128/mcb.00317-07.

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ABSTRACT Activation of peroxisome proliferator-activated receptor α (PPARα) leads to hepatocellular proliferation and liver carcinomas. The early events mediating these effects are unknown. A novel mechanism by which PPARα regulates gene expression and hepatocellular proliferation was uncovered. MicroRNA (miRNA) expression profiling demonstrated that activated PPARα was a major regulator of hepatic miRNA expression. Of particular interest, let-7C, an miRNA important in cell growth, was inhibited following 4-h treatment and 2-week and 11-month sustained treatment with the potent PPARα agonist W

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Zergani, Emel, Amir Rashidi, Jalal Rostamzadeh, Jens Tetens, and Mohammad Razmkabir. "Effect of a Novel Variant with Let-7c MicroRNA Gene on Litter Size in Markhoz Goats." Ruminants 2, no. 4 (2022): 471–77. http://dx.doi.org/10.3390/ruminants2040033.

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This study was focused on identifying the effects of single nucleotide polymorphisms (SNPs) located on an entire region of the let-7c miRNA gene with consideration of its ability to promote litter size in Markhoz goats. The Markhoz goat, the native breed in Iran, is important for its reproductive traits, such as litter size. DNA polymorphism of let-7c miRNA gene was revealed and considered for further studies for its effect on litter size in Markhoz goats. PCR-SSCP analysis investigated different band patterns for this miRNA; however, sequencing results have detected only an A to T substitutio

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Wang, Lan, Jing Zou, and Jing Zhang. "Dysregulation of let-7c-5p/Tyrosyl-DNA phosphodiesterase 1 axis indicates an unfavorable outcome in gastric cancer." European Journal of Inflammation 20 (January 2022): 205873922110692. http://dx.doi.org/10.1177/20587392211069258.

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Introduction Tyrosyl-DNA phosphodiesterase 1 (TDP1) can repair oxidative damage-caused 3′-phosphoglycolates and promote cancer progression. However, the clinical significance of TDP1 and its correlation with microRNAs (miRNAs) in gastric cancer (GC) remains unknown. Methods The relationship of TDP1 or let-7c-5p with the clinical outcomes of GC was determined by a tissue microarray and TCGA dataset. Cell viability and invasion were assessed by MTT and Transwell assays. Pearson correlation analysis, luciferase gene report, qRT-PCR, and Western blot analyses were used to analyze the interaction b

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Fan, James, Joanna Gemel, Eric C. Beyer, and Gabrielle Lapping-Carr. "Plasma Levels of MicroRNA Let-7c-5p May Predict Risk of Acute Chest Syndrome in Patients with Sickle Cell Disease." International Journal of Molecular Sciences 26, no. 8 (2025): 3831. https://doi.org/10.3390/ijms26083831.

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Acute chest syndrome (ACS) is among the most serious complications of sickle cell disease (SCD). While the pathogenesis of ACS is incompletely understood, endothelial damage and microvascular occlusion are critical components. Our previous studies have implicated small extracellular vesicles in the plasma of subjects with SCD in causing endothelial dysfunction. This suggested that microRNAs within these small EVs might be responsible for endothelial damage. The sequencing of microRNAs in small EVs from the plasma of subjects with SCD revealed that several miRNAs were differentially expressed b

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Zhang, Hang-Hu, Cai-Xue Li, and Lan-Fang Tang. "The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies." Journal of Evidence-Based Integrative Medicine 24 (January 1, 2019): 2515690X1882190. http://dx.doi.org/10.1177/2515690x18821906.

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The aim of this study was to investigate the expression patterns of miRNA-let 7a, 7b, and 7c in bronchoalveolar lavage fluid in infants with asthma and airway foreign bodies. Between January 2016 and February 2017, 27 infants were included and divided into observation group (infants with asthma, n = 15) and control group (infants with airway foreign bodies, n = 12). The differential expression profiles of miRNA-let 7a, 7b, and 7c were determined by reverse transcription–polymerase chain reaction in bronchoalveolar lavage fluid (BALF) from infants of the 2 groups. The BALF was collected from in

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Dissertations / Theses on the topic "Let-7c"

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Prassek, Victoria [Verfasser], Inge [Akademischer Betreuer] [Gutachter] Bauer, and Orhan [Gutachter] Aktas. "Differentielle Expression von microRNAs im Spinalganglion in einem chronisch neuropathischen Schmerzmodell der Ratte und Untersuchung einer Interaktion zwischen der microRNA-let-7c und dem Nerve Growth Factor / Victoria Prassek ; Gutachter: Inge Bauer, Orhan Aktas ; Betreuer: Inge Bauer." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1127200194/34.

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Conference papers on the topic "Let-7c"

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Wang, Rui, Guoqing Wang, Jacqueline Salit, Joumana Ahmed, and Ronald G. Crystal. "Role Of MiRNA Let-7c In Modulating Differentiation Of Human Airway Epithelium." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6326.

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Nadiminty, Nagalakshmi, Ramakumar Tummala, Jae Yeon Chun, et al. "Abstract 4001: Lin28/miR-let-7c axis controls the growth and tumorigenicity of prostate cancer cells." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4001.

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Yuan, Huijun, Sukanya Sil, Salil Sharma, and Nanette Bishopric. "Abstract 4882: Loss of p300 reduces miR-let-7c and enhances ER-positive breast cancer cell tumorigenicity." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4882.

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Kurniawati, Ida, Chia-Yen Hsueh, Shian-Ying Sung, and Chia-Ling Hsieh. "Abstract 1151: Targeting castration-resistant prostate cancer using mesenchymal stem cell exosomes for therapeutic microRNA let-7c delivery." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1151.

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Su, B. H., C. L. Wu та Y. L. Tseng. "Downregulation of MicroRNA-1, 133, and Let-7c Reduces to Control Prothymosin α Expression, A Novel Role in Chronic Obstructive Pulmonary Disease". У American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6158.

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Liu, Shuman, Xuesen Li, Zhongbo Liu, et al. "Abstract 5580: Simvastatin induces expression of miRNA-200a and let-7c, leading to mRNA and protein expression of E-cadherin and reduced cell migration in PC-3 cells." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-5580.

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Banerjee, Hirendra N., Fazlul Sarkar, Myla Worthington, Sasha Hodge, Mukesh Verma, and Santosh Mandal. "Abstract 3065: Role of noncoding RNA miR 146 alpha and let 7c in epithelial mesenchymal transition, proliferation, and cancer stem cell-like transformation analyzed by gene expression studies in a cohort of prostate cancer patients." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3065.

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