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Journal articles on the topic 'Lethal cases'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Brødsgaard, Inger, A. Carsten Hansen, and Annie Vesterby. "Two Cases of Lethal Nitrazepam Poisoning." American Journal of Forensic Medicine and Pathology 16, no. 2 (1995): 151–53. http://dx.doi.org/10.1097/00000433-199506000-00015.

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2

Gustavson, Karl-Henrik, Gösta Holmgren, Sten Jagell, and Håkan Jorulf. "Lethal and non-lethal diastrophic dysplasia A study of 14 Swedish cases." Clinical Genetics 28, no. 4 (2008): 321–34. http://dx.doi.org/10.1111/j.1399-0004.1985.tb00406.x.

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3

Kindrativ, E. O., V. M. Vasylyk, V. M. Matskevych, V. M. Kostyuk, V. A. Semchenko, and V. O. Voronych. "RETROSPECTIVE ANALYSIS OF CORONAVIRUS DISEASE LETHAL CASES." Fiziolohichnyĭ zhurnal 67, no. 4 (2021): 76–85. http://dx.doi.org/10.15407/fz67.04.076.

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There was performed a statistical analysis of 164 records of pathological examination of persons who died of coronavirus disease during April-November, 2020. It is determined that the share of males was 62.20%, and females – 37.80%; the average age of the deceased persons was 64.40 ± 13.79 years. The largest number of lethal cases (57.32%) falls on the age category of 60-79 years, and the smallest (6.71%) – on the age category of 20-39 years. It is important that men predominate in all age groups. The most common direct causes of death were: respiratory failure – 78.05%, multiorgan failure – 1

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4

TUDEHOPE, D. I. "TWO LETHAL CASES OF CONGENITAL VARICELIA SYNDROME." Journal of Paediatrics and Child Health 31, no. 3 (1995): 259. http://dx.doi.org/10.1111/j.1440-1754.1995.tb00800.x.

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5

Jahrsdoerfer, Robert A., Gale Gardner, Joel W. Yeakley, and Charles R. Karam. "Lethal Cholesteatoma." Otolaryngology–Head and Neck Surgery 95, no. 4 (1986): 507–10. http://dx.doi.org/10.1177/019459988609500415.

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Aural cholesteatoma Is a disease entity well known to the otologic community. Complications of cholesteatoma, although uncommon, are not usually life threatening. We present two cases in which a unique and hitherto unreported pathway of spread of a cholesteatoma is noted. The cholesteatoma, after originating in the ear, entered the diploe and spread insidiously between the inner and outer tables to distal parts of the skull. Osteomyelitis, in concert with the cholesteatoma, destroyed large areas of the skull in both patients. One patient died of his disease. The other patient was operated on a

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6

Makovický, Peter, Radek Matlach, and Pavol Makovický. "Lethal alcohol intoxications cases: thinking about the causes." Vnitřní lékařství 67, no. 8 (2021): E29—E36. http://dx.doi.org/10.36290/vnl.2021.132.

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7

Škavić, Petar, Zijad Duraković, and Marina Nestić. "Lethal Bentazone Intoxication - A Report of Two Cases." Journal of Forensic Sciences 63, no. 1 (2017): 321–25. http://dx.doi.org/10.1111/1556-4029.13518.

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Chalyan, V. G., N. V. Meishvili, I. G. Pachulia, E. N. Anikaeva, and D. V. Zadorojnii. "Lethal Aggression in Captive Monkeys." Российский физиологический журнал им И М Сеченова 109, no. 2 (2023): 178–91. http://dx.doi.org/10.31857/s0869813923020036.

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Establishing the characteristics of monkey lethal aggression, assessing the age and sex of aggressors and victims, and the nature of the aggressors' actions seems necessary to identify the evolutionary roots of cases of human lethal aggression. In addition, the study of the features of lethal aggression can be considered as a condition for the development of measures aimed at preventing its manifestations in captive monkeys. The aim of the study is to study the species-specific features of lethal aggression in captive macaques, baboons and guenons. An analysis was made of cases of intra-group

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9

Rantapero, Tommi, Tiina Wahlfors, Anna Kähler, et al. "Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer." Genes 11, no. 3 (2020): 314. http://dx.doi.org/10.3390/genes11030314.

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Germline variants in DNA repair genes are associated with aggressive prostate cancer (PrCa). The aim of this study was to characterize germline variants in DNA repair genes associated with lethal PrCa in Finnish and Swedish populations. Whole-exome sequencing was performed for 122 lethal and 60 unselected PrCa cases. Among the lethal cases, a total of 16 potentially damaging protein-truncating variants in DNA repair genes were identified in 15 men (12.3%). Mutations were found in six genes with CHEK2 (4.1%) and ATM (3.3%) being most frequently mutated. Overall, the carrier rate of truncating v

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10

Takakuwa, Tetsuya, Shigeatsu Endo, Hajime Nakae, and Shigeru Taniguchi. "Studies on cases with lethal level of blood alcohol." Nihon Kyukyu Igakukai Zasshi 6, no. 2 (1995): 155–61. http://dx.doi.org/10.3893/jjaam.6.155.

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11

Lupariello, Francesco, and Giancarlo Di Vella. "A Stricter Approach for Commotio Cordis in Lethal Cases." American Journal of Cardiology 124, no. 10 (2019): 1649. http://dx.doi.org/10.1016/j.amjcard.2019.08.005.

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12

Belmont, John W., Edith Hawkins, J. Fielding Hejtmancik, Frank Greenberg, John M. Opitz, and James F. Reynolds. "Two cases of severe lethal Smith-Lemli-Opitz syndrome." American Journal of Medical Genetics 26, no. 1 (1987): 65–67. http://dx.doi.org/10.1002/ajmg.1320260112.

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13

Ducháčová, Michaela, Jan Pavlíček, Eva Pavlíčková, et al. "Lethal syndromes in pediatrics - three cases of trisomy 18." Pediatrie pro praxi 24, no. 2 (2023): 111–15. http://dx.doi.org/10.36290/ped.2023.033.

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14

Obladen, Michael. "Lethal Lullabies." Journal of Human Lactation 32, no. 1 (2015): 75–85. http://dx.doi.org/10.1177/0890334415594615.

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Poppy extract accompanied the human infant for more than 3 millenia. Motives for its use included excessive crying, suspected pain, and diarrhea. In antiquity, infantile sleeplessness was regarded as a disease. When treatment with opium was recommended by Galen, Rhazes, and Avicenna, baby sedation made its way into early medical treatises and pediatric instructions. Dabbing maternal nipples with bitter substances and drugging the infant with opium were used to hasten weaning. A freerider of gum lancing, opiates joined the treatment of difficult teething in the 17th century. Foundling hospitals

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15

Orbons, Sjef, and Lambèr Royakkers. "Non-Lethal Weapons." International Journal of Technoethics 5, no. 1 (2014): 15–27. http://dx.doi.org/10.4018/ijt.2014010102.

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In missions to stabilize conflicts around the world, the military forces increasingly find themselves operating amongst the people. The emerging need in military interventions to prevent casualties translated into a range of value driven military technological developments, such as non-lethal weapons (NLW). NLWs can be characterized by a certain technological and operational design 'window' of permissible physiological effect, defined at each end by values: one value is a controlled physiological impact to enforce compliance by targeted individuals, the other value is the prevention of inflict

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16

Giyasov, Z. A., and S. A. Khakimov. "Forensic Description Of Cases Of Noletal Asphyxia." American Journal of Medical Sciences and Pharmaceutical Research 03, no. 08 (2021): 58–68. http://dx.doi.org/10.37547/tajmspr/volume03issue08-10.

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This article discusses the forensic description of cases of Noletal asphyxia. Expertise materials on postasphystic cases in 2017-2020 in three regions of the country were studied. Incomplete asphyxia during this period accounted for 0.31% of the total number of forensic medical examinations of survivors, and the ratio of examinations for nonlethal and lethal asphyxia was 1: 6.6%. Non-lethal asphyxia was more often observed in men, in persons aged 19-39 years, after an attempt at self-improvement, in the morning and afternoon hours. The duration of asphyxia, loss of consciousness, and the sever

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17

Rivlin, Adrienne, Keith Hawton, Lisa Marzano, and Seena Fazel. "Psychiatric disorders in male prisoners who made near-lethal suicide attempts: case–control study." British Journal of Psychiatry 197, no. 4 (2010): 313–19. http://dx.doi.org/10.1192/bjp.bp.110.077883.

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BackgroundAlthough male prisoners are five times more likely to die by suicide than men of a similar age in the general population, the contribution of psychiatric disorders is not known.AimsTo investigate the association of psychiatric disorders with near-lethal suicide attempts in male prisoners.MethodA matched case–control study of 60 male prisoners who made near-lethal suicide attempts (cases) and 60 prisoners who had never carried out near-lethal suicide attempts in prison (controls) was conducted. Psychiatric disorders were identified with the Mini International Neuropsychiatric Intervie

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18

Naelitz, Bryan Douglas, Chad A. Reichard, Zeneng Wang, et al. "Gut microbiota-associated compounds increase lethal prostate cancer risk." Journal of Clinical Oncology 39, no. 6_suppl (2021): 147. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.147.

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147 Background: Gut-microbiota-mediated metabolism of trimethylamine-associated nutrients and amino acids has been linked to altered cholesterol metabolism and endothelial inflammation. However, the association between these compounds and lethal prostate cancer (PCa) remains unknown. Methods: A nested case-control study was performed using samples from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial to evaluate the association between baseline serum levels of target metabolites (choline, carnitine, betaine, γ-butyrobetaine, crotonobetaine, trimethylamine N-oxide, phen

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19

Windfuhr, Jochen P., Georg Schloendorff, Diwa Baburi, and Bernd Kremer. "Hemorrhagic Shock and Death following Tonsillectomy." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P38. http://dx.doi.org/10.1016/j.otohns.2008.05.125.

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Objective Evaluate the incidence and clinical course of serious bleeding complications following tonsillectomy, in terms of hemorrhagic shock and death. Methods Cases with lethal outcome or presenting with hemorrhagic shock, requiring resuscitation or major medical treatment between 1980 and 2007, were collected based on personal experiences and material collected after a plea published in a national journal. Results 113 cases were eligible for further analysis, comprising 30 cases with lethal outcome (19 children, 11 adults). 83 patients had experienced serious bleeding complications (36 chil

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Semenov, A. V., and L. A. Zimina. "The unusual cases of mechanical asphyxia with the lethal outcome." Sudebno-meditsinskaya ekspertiza 60, no. 1 (2017): 39. http://dx.doi.org/10.17116/sudmed201760139-41.

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21

Gubin, Mykola, Vasil Olkhovsky, and Edgar Grygorian. "FORENSIC MEDICAL EXAMINATION IN CASES OF NON-LETHAL LARYNX TRAUMAS." Inter Collegas 6, no. 2 (2019): 88–92. http://dx.doi.org/10.35339/ic.6.2.88-92.

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FORENSIС MEDICAL EXAMINATION IN NON-FATAL LARYNGEAL TRAUMA Olkhovsky V.O., Gubin M.V., Grygorian E.K.  Victims with non-fatal laryngeal trauma become the object of forensic medical evaluation of the severity of bodily injuries in alive persons, carried out during pre-judicial and judicial investigation. The purpose of the study was to provide morphological and clinical analysis and characteristics of bodily injuries in cases of blunt laryngeal trauma in forensic medical examination of alive persons, to determine ways to improve the effectiveness of forensic medical diagnosis of the

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22

Miller, Catherine R., Kendall Von Crowns, and Vickie Willoughby. "Fatal Ludwig's Angina: Cases of Lethal Spread of Odontogenic Infection." Academic Forensic Pathology 8, no. 1 (2018): 150–69. http://dx.doi.org/10.23907/2018.011.

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We report two cases of deaths resulting from complications of odontogenic infections/submandibular space infections. In one case, the decedent had a history of toothache as well as facial and tongue swelling; autopsy revealed inflammation involving the tongue and larynx. In the second case, the decedent had a history of toothache, and at autopsy there was spread of infection to the mediastinum. Ludwig's angina is a form of submandibular space infection, which often is a result of odontogenic infection. The infection can spread into the deep spaces of the neck, producing complications including

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23

Цинзерлинг, В. А., Н. А. Луговская, Н. Ю. Семенова, Ю. И. Вайншенкер, В. А. Орлова, and И. И. Михайлова. "Brain Chlamydiosis in Patients with Schizophrenia (Lethal Cases from Practice)." Психиатрия, психотерапия и клиническая психология 15, no. 1 (2024): 107–18. http://dx.doi.org/10.34883/pi.2024.15.1.005.

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В работе описаны 2 клинических случая смерти: 37-летней женщины, на протяжении 27 лет страдавшей параноидной формой шизофрении и погибшей на фоне осложнений новой коронавирусной инфекции, и 47-летнего мужчины, длительное время страдавшего простой шизофренией с непрерывным течением и умершего в связи с осложнениями перфоративного калькулезного холецистита. При патологоанатомическом исследовании на основании гистологического и иммуногистохимического исследований у обоих пациентов диагностирована хламидийная инфекция (в первом случае генерализованная) с массивным поражением белого и серого вещест

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Prieto-Granada, Carlos N., Cecilia Lezcano, Richard A. Scolyer, Martin C. Mihm, and Adriano Piris. "Lethal melanoma in children: a clinicopathological study of 12 cases." Pathology 48, no. 7 (2016): 705–11. http://dx.doi.org/10.1016/j.pathol.2016.08.008.

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25

Torres, Jaime R., Códova G. Leopoldo, Julio S. Castro, et al. "Chikungunya fever: Atypical and lethal cases in the Western hemisphere." IDCases 2, no. 1 (2015): 6–10. http://dx.doi.org/10.1016/j.idcr.2014.12.002.

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26

Martin, Nicole J., J. Brian Hill, David H. Cooper, et al. "Lethal multiple pterygium syndrome: Three consecutive cases in one family." American Journal of Medical Genetics 24, no. 2 (1986): 295–304. http://dx.doi.org/10.1002/ajmg.1320240210.

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27

Byard, Roger W. "Lethal explosions in a non-terrorist civilian setting." Medicine, Science and the Law 58, no. 3 (2018): 156–58. http://dx.doi.org/10.1177/0025802418767797.

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A study was undertaken to investigate the range and nature of deaths that may result from explosions in a civilian population that has not been exposed to terrorist attacks or significant military activities. A search was conducted of autopsy files at Forensic Science SA, Adelaide, Australia, from July 2000 to June 2017 for all cases where death had been attributed to an explosion. Twenty cases were identified, consisting of 10 accidents, five suicides, two homicides, one murder-suicide with two decedents and one case where the manner of death was undetermined. Explosives were involved in nine

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Pogodina, V. V., S. V. Luchinina, O. N. Stepanova, et al. "Unusual case of lethal tick-borne encephalitis in patient vaccinated with vaccines produced from different viruses strains (the Chelyabinsk Region)." Epidemiology and Infectious Diseases 20, no. 1 (2015): 56–64. http://dx.doi.org/10.17816/eid40869.

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Lethal cases of tick-borne encephalitis in previously vaccinated patients have not been described. Modern inactivated vaccines against Tick-borne encephalitis (TBE) are high effective. The TBE cases, preference unfocal forms, are developed in persons with incomplete irregular vaccination. First case of lethal TBE after plural vaccination was described in the Kurgan region, the second case - in the Chelyabinsk region. These very rare unusual cases were studied. Being dominant the Siberian subtype of TBE virus is related with lethal TBE cases in the Chelyabinsk region. Unusual TBE case was devel

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29

Marzano, Lisa, Seena Fazel, Adrienne Rivlin, and Keith Hawton. "Psychiatric disorders in women prisoners who have engaged in near-lethal self-harm: case–control study." British Journal of Psychiatry 197, no. 3 (2010): 219–26. http://dx.doi.org/10.1192/bjp.bp.109.075424.

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BackgroundFemale prisoners are 20 times more likely to die by suicide than women of the same age in the general population. However, risk factors and indicators of vulnerability for suicide in this group are not well-known.AimsWe investigated prevalence of psychiatric disorders in women prisoners who had recently engaged in near-lethal self-harm (cases) and others who had never carried out near-lethal attempts in prison (controls).MethodWe interviewed 60 cases and 60 controls from all closed female prison establishments in England and Wales. In addition to gathering details of sociodemographic

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30

Nakamura-Utsunomiya, Akari, Satoshi Okada, Keiichi Hara, et al. "Clinical Characteristics of Perinatal Lethal Hypophosphatasia: A Report of 6 Cases." Clinical Pediatric Endocrinology 19, no. 1 (2010): 7–13. http://dx.doi.org/10.1297/cpe.19.7.

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31

Mai, Tingting, Youyou Zhang, and Shuquan Zhao. "Xylazine Poisoning in Clinical and Forensic Practice: Analysis Method, Characteristics, Mechanism and Future Challenges." Toxics 11, no. 12 (2023): 1012. http://dx.doi.org/10.3390/toxics11121012.

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Xylazine abuse is emerging globally, while the identification of xylazine lethal cases poses a great challenge in clinical and forensic practice. The non-specific symptoms delay the diagnosis and treatment of xylazine poisoning, the pathological changes and lethal concentration of xylazine in body fluid and organs of fatal xylazine poisoning cases are seldom reported and the other toxins detected in such cases complicate the role of xylazine in the cause of death. Therefore, we carefully reviewed related updated information on xylazine, summarized the knowledge from clinical and forensic persp

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Gubin, M. V., G. I. Garyuk, I. Y. Serbinenko, V. M. Gubin, and O. M. Irklienko. "FORENSIC MEDICAL ASSESSMENT OF INJURY SEVERITY OF LARYNX AND HYOID BONE BASED ON PRE-JUDICIAL AND JUDICIAL INVESTIGATION." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 21, no. 3 (2021): 196–200. http://dx.doi.org/10.31718/2077-1096.21.3.196.

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Victims with fatal and non-fatal closed blunt trauma of the larynx and hyoid bone often become the object of forensic medical service during the pre-judicial and judicial investigation. The purpose of this study is to analyze the features of expert qualification of bodily injuries in victims with closed blunt trauma of the larynx and hyoid bone, depending on the nature and severity to determine ways to unify its forensic diagnosis. Materials and methods. The study was based on the conclusions of 35 forensic medical examinations of cases of closed blunt trauma of the larynx and hyoid bone, obta

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Vasilyeva, I. A., V. V. Testov, S. A. Sterlikov, V. S. Burykhin, V. G. Kudrina, and N. D. Urushadze. "Lethal Risk Factors in Patients with Rifampicin Resistant Tuberculosis according to Federal Register of Tuberculosis Cases." Tuberculosis and Lung Diseases 102, no. 6 (2024): 40–47. https://doi.org/10.58838/2075-1230-2024-102-6-40-47.

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The objective: to study the factors inﬂuencing the risk and timing of a lethal outcome in tuberculosis patients with conﬁrmed resistance to rifampicin in general population (Federal Register of Tuberculosis Cases of the Russian Federation (FRTBC)).Subjects and Methods. 15,604 tuberculosis patients with conﬁrmed resistance to at least rifampicin and registered for treatment in 2021 were enrolled in a retrospective cohort study of lethal outcome predictors in general population (Federal Register of Tuberculosis Cases of the Russian Federation (FRTBC)).Results. The leading lethal risk factors wer

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34

Castanet, J., J. P. Lacour, C. Perrin, I. Bodokh, J. F. Dor, and J. P. Ortonne. "Escherichia coli cellulitis: two cases." Acta Dermato-Venereologica 72, no. 4 (1992): 310–11. http://dx.doi.org/10.2340/0001555572310311.

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We report two cases of cellulitis of the legs occurring in adults where Escherichia coli (E. coli) was, or probably was, the causative bacterial agent. E. coli and other gram-negative bacilli cellulitis are rarely reported. However, in cellulitis, the causative microorganism is rarely identified, and some cases of E. coli cellulitis could be unrecognized. Furthermore, classical risk factors for gram-negative sepsis are characterized by a state of leucocyte dysfunction which could explain the possibility of a severe, even lethal, course of gram-negative cellulitis. Therefore, the occurrence of

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Palma-Lara, Icela, Monserrat Pérez-Ramírez, Patricia García Alonso-Themann, et al. "FAM20C Overview: Classic and Novel Targets, Pathogenic Variants and Raine Syndrome Phenotypes." International Journal of Molecular Sciences 22, no. 15 (2021): 8039. http://dx.doi.org/10.3390/ijms22158039.

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FAM20C is a gene coding for a protein kinase that targets S-X-E/pS motifs on different phosphoproteins belonging to diverse tissues. Pathogenic variants of FAM20C are responsible for Raine syndrome (RS), initially described as a lethal and congenital osteosclerotic dysplasia characterized by generalized atherosclerosis with periosteal bone formation, characteristic facial dysmorphisms and intracerebral calcifications. The aim of this review is to give an overview of targets and variants of FAM20C as well as RS aspects. We performed a wide phenotypic review focusing on clinical aspects and diff

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Osman, Abdelkarim A., and Mohamed H. Khurasani. "Lethal Catatonia and Neuroleptic Malignant Syndrome." British Journal of Psychiatry 165, no. 4 (1994): 548–50. http://dx.doi.org/10.1192/bjp.165.4.548.

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BackgroundLethal catatonia and neuroleptic malignant syndrome (NMS) have been suggested to have a common neurochemical cause. We hypothesise that both conditions may be due to a sudden and massive blockade of dopamine neurotransmitters.MethodNMS was diagnosed in psychotic in-patients treated with neuroleptics if four features were present: diffuse severe rigidity, altered level of consciousness, hyperpyrexia and autonomic instability.ResultsOver three years, five NMS cases were diagnosed. Two presented with catatonic features and were diagnosed as acute reactive psychosis. Their neuroleptic do

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Pillai, Swapna Surendran, Abeer Hassinar, Sathiamma Puthuvilayil Kutty, and Girija Devi. "Spontaneous hemoperitoneum in pregnancy: report of two cases." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 8 (2024): 2167–70. http://dx.doi.org/10.18203/2320-1770.ijrcog20242092.

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The condition known as spontaneous hemoperitoneum in pregnancy (SHiP) is characterized by an accumulation of fluid in the abdominal cavity and a vague collection of symptoms. Specifically, intrauterine pregnancy increases the chance of death for both the mother and the fetus, making SHiP a potentially lethal illness when it coexists. Here, we discuss two cases of spontaneous hemoperitoneum in pregnancy that resulted from placenta accreta spectrum and endometriosis, and happened in the second and third trimesters, respectively.

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Shiozaki, Tadahiko, Yasumitsu Mizobata, Hisashi Sugimoto, Toshiharu Yoshioka, and Tsuyoshi Sugimoto. "Fulminant Hepatitis following Exposure to Dichlorohydrin — Report of Two Cases." Human & Experimental Toxicology 13, no. 4 (1994): 267–70. http://dx.doi.org/10.1177/096032719401300408.

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A 34-year-old man suffered from fulminant hepatitis after cleaning a tank in which there were traces of dichlorohydrin. In spite of daily plasma exchanges, he died 10 days after exposure. A 27-year-old man with much lighter exposure showed only slight liver dysfunction. This is the first report of lethal injury following exposure to dichlorohydrin.

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Linskens, Ingeborg H., Ruurd M. van Elburg, Dick Oepkes, John M. G. van Vugt, and Monique C. Haak. "Expectant Management in Twin Pregnancies With Discordant Structural Fetal Anomalies." Twin Research and Human Genetics 14, no. 3 (2011): 283–89. http://dx.doi.org/10.1375/twin.14.3.283.

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Objective:Routine obstetric ultrasound increasingly leads to the detection of structural fetal anomalies. In twin pregnancies with one anomalous twin, counseling on management strategies is complicated. Patients and methods: Twin pregnancies (n= 212) were referred to a tertiary center between January 2007 and July 2009. In a retrospective analysis, twins discordant for a structural fetal anomaly were compared to twins without anomalies in the prenatal ultrasound. Outcome parameters were survival and gestational age at birth.Results:Anomalies were seen in at least one fetus of 30 twin pairs. Th

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Johnson, Tonya L., Lois M. Jessen, and Joseph A. Barone. "Trends in Emergency Department Overdose Cases." Journal of Pharmacy Practice 10, no. 4 (1997): 229–34. http://dx.doi.org/10.1177/089719009701000403.

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Though drug overdose episodes represent only 0.5% of total emergency department visits, there have been increased numbers and changes in specific agents of abuse. When treating ED patients, factors such as multi-drug abuse, age and gender of patients, and changes in purity of street drugs must be considered. Medication misuse and abuse by the elderly require particular attention in light of the increasing geriatric population. Health care practitioners must also be aware of geographic trends in drug abuse and designer drug manufacture. The most frequent substances involved in human exposures a

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41

Beer, Martin. "Lethal Encephalitis of Unknown Origin—Elucidation by Metagenomics." Proceedings 50, no. 1 (2020): 59. http://dx.doi.org/10.3390/proceedings2020050059.

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Novel and (re)emerging viruses cause frequent threats to both human and animal health. Diagnostic metagenomics using unbiased next-generation sequencing (NGS) is the key method for the identification of new pathogens. With today’s available state-of-the-art platforms, NGS can be broadly used to also identify novel and unknown pathogens in different sample materials (even in point-of-care diagnostics) or to characterize the complete genomes of all types of pathogens. Nevertheless, the extreme numbers of sequence fragments resulting from NGS analyses requires not only novel diagnostic pipelines

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Hovsepyan, Argam, Rouben Hovhannesyan, and Karen Mkhitaryan. "Cause-effect relations between defects of medical care and lethal outcome." Issues of Forensic Science 310 (2020): 67–70. http://dx.doi.org/10.34836/pk.2020.310.4.

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The article discusses the issues of identifying and determining the cause-effect relations between defects in the provision of medical care and lethal outcome based on the materials of commission forensic medical expertise. In the presence of defects in the provision of medical care in 30.3% of cases a cause-effect relation was detected between the frequency of defects in medical care and the likelihood of lethal outcome. The likelihood of the occurrence of lethal outcome was most influenced by defects in diagnosis (RR = 2.41) and treatment (RR = 15.65).

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Galkin, Fedor, Austin Parish, Evelyne Bischof, John Zhang, Polina Mamoshina, and Alex Zhavoronkov. "Increased Pace of Aging in COVID-Related Mortality." Life 11, no. 8 (2021): 730. http://dx.doi.org/10.3390/life11080730.

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Identifying prognostic biomarkers and risk stratification for COVID-19 patients is a challenging necessity. One of the core survival factors is patient age. However, chronological age is often severely biased due to dormant conditions and existing comorbidities. In this retrospective cohort study, we analyzed the data from 5315 COVID-19 patients (1689 lethal cases) admitted to 11 public hospitals in New York City from 1 March 2020 to 1 December. We calculated patients’ pace of aging with BloodAge—a deep learning aging clock trained on clinical blood tests. We further constructed survival model

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Zinchuk, A. M., A. M. Zadorozhnyi, N. M. Prykuda, and G. P. Sosna. "Clinical and etilogical characteristics of lethal cases of purulent meningitis in adults." Bukovinian Medical Herald 22, no. 1 (85) (2018): 36–45. http://dx.doi.org/10.24061/2413-0737.xxii.1.85.2018.6.

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Kovalоva, O. M., V. I. Pokhylko, N. S. Artyomova, Yu I. Cherniavska, and A. V. Slyusareva. "INTRAVENTRICULAR HEMORRHAGES IN NEONATOLOGY: PREDICTION OF THE LETHAL CASES IN PREMATURE INFANTS." Neonatology, surgery and perinatal medicine 9, no. 1(31) (2019): 16–22. http://dx.doi.org/10.24061/2413-4260.ix.1.31.2019.2.

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Ingemarsson, Ingemar, and John A. D. Spencer. "Fetal seizure activity associated with lethal cerebral damage at birth: two cases." Acta Obstetricia et Gynecologica Scandinavica 77, no. 1 (1998): 127–29. http://dx.doi.org/10.1080/00016349808565828.

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Brierley, Joe. "Current status of potential organ donation in cases of lethal fetal anomaly." Obstetrician & Gynaecologist 15, no. 3 (2013): 184–88. http://dx.doi.org/10.1111/tog.12027.

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Zonneveld, Rens, Jimmy Roosblad, Jan Willem van Staveren, Jan C. Wilschut, Stephen G. S. Vreden, and John Codrington. "Three atypical lethal cases associated with acute Zika virus infection in Suriname." IDCases 5 (2016): 49–53. http://dx.doi.org/10.1016/j.idcr.2016.07.009.

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Filonovich, V. P. "Two cases of vaginal stenosis." Journal of obstetrics and women's diseases 8, no. 10 (2020): 887–93. http://dx.doi.org/10.17816/jowd810887-893.

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Acquired cicatricial narrowing of the vagina, which is quite rare, is of great interest in the therapeutic relationship for the obstetrician and gynecologist. What a serious obstacle is vaginal stenosis for a pregnant uterus during childbirth - can be seen from the article by Merz, posted in Archif fr Gyncologie, Bd XLV: for 230 cases of rupture of the pregnant uterus collected from the literature over the last 20 years, 16 caused vaginal stenosis. Timely removal of this obstacle would save 16 lives! It must be assumed that a huge number of cases, in addition, remain unpublished; in November l

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de Sá, Keyla S. G., Luana A. Amaral, Tamara S. Rodrigues, et al. "Pulmonary inflammation and viral replication define distinct clinical outcomes in fatal cases of COVID-19." PLOS Pathogens 20, no. 6 (2024): e1012222. http://dx.doi.org/10.1371/journal.ppat.1012222.

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COVID-19 has affected more than half a billion people worldwide, with more than 6.3 million deaths, but the pathophysiological mechanisms involved in lethal cases and the host determinants that determine the different clinical outcomes are still unclear. In this study, we assessed lung autopsies of 47 COVID-19 patients and examined the inflammatory profiles, viral loads, and inflammasome activation. Additionally, we correlated these factors with the patient’s clinical and histopathological conditions. Robust inflammasome activation was detected in the lungs of lethal cases of SARS-CoV-2. Exper

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