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Journal articles on the topic 'Letterer'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Shalyga, I. F., G. V. Tishchenko, L. A. Martemyanova, S. Yu Turchenko, and Yu N. Avizhets. "Letterer-Siwe disease." Health and Ecology Issues, no. 2 (June 28, 2018): 99–103. http://dx.doi.org/10.51523/2708-6011.2018-15-2-20.

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The article describes a case of Letterer-Siwe disease (Langerhans cells histocytosis, histiocytosis X) in a 1-year-old infant, presents the authors` own observations focusing on the macroscopic and histological picture of skin lesions. The work also notes difficulties of diagnosis of this disease. Reliable morphological features of Letterer-Siwe disease were revealed during the histologic examination of the skin.

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2

Nasar, Sri S., and E. M. Dadi Sujoko. "Letterer-Siwe’s Disease." Paediatrica Indonesiana 14, no. 1-2 (2017): 33. http://dx.doi.org/10.14238/pi14.1-2.1974.33-38.

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The present report concerns a case of Letterer-Siwe's disease which satisfies the clinical and pathological findings of acute non-lipid reticuloendotheliosis. This is the third case reported in our clinic, the former two were reported by Kho et al. (1961) and Iskandar et al. (1966). Two other cases from other clinics were reported by Tangosaputra and Himawan (1970).

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3

Agarwal, Preeti, Fatima Khan, Vaibhav Gupta, and Devanshi Dubey. "Liquid based cytology and immunohistochemistry on cytosmears based diagnosis of letterer-siwe disease in a 40 year male." Indian Journal of Pathology and Oncology 8, no. 4 (2021): 508–11. http://dx.doi.org/10.18231/j.ijpo.2021.105.

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: Histiocytes with coffee bean like nucleus are the diagnostic hallmark of Langerhans cell histiocytosis (LCH) supported with immunohistochemical (IHC) demonstration of fascin, CD1a and S-100. We report a case of Letterer-Siwe disease in a 40year male diagnosed on cytology and IHC on cytosmears along with cytomorphology in Liquid based cytology (LBC) smears. Forty year male presented with complains of low grade fever and reduced appetite from two years with a cervical swelling and discomfort from five months. Fine needle aspiration(FNA) from cervical lymph node showed sheets of histiocytes in

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4

Cabieses Molina, Fernando, and Rodolfo Landa Cannon. "Granuloma Eosinofílico del hueso." Anales de la Facultad de Medicina 36, no. 2 (2014): 223. http://dx.doi.org/10.15381/anales.v36i2.9186.

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Se presentan cuatro casos de granuloma eosinofílico monostótico. Tres de ellos localizados en el cráneo y uno localizado en una vértebra. Se recalca las relaciones existentes entre esta entidad nosológica y la enfermedad de Hand-Schuller-Christian y Letterer-Siwe, destacándose la benignidad del granuloma eosinofílico monostótico.

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5

H H, Suad, Mona Mohamed Elamin, Gad Allah Modawe, and Khalid AbdElmohsin Awad Elseed. "Letterer Siwe Disease (LSD): A Case Report." Sudan Journal of Medical Sciences 13, no. 3 (2018): 207. http://dx.doi.org/10.18502/sjms.v13i3.2958.

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Background: Letterer Siwe Disease (LSD) is one of variants of langerhans cell histiocytosis (LCH) which is considered as a rare disease that affects many systems in the body, it is characterized by monoclonal migration and proliferation of specific dendritic cells. The disease affects the bones and skin primarily, but can involve other organs as well or appear as a multi-system disease leading to different clinical manifestations and eventually death.

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6

Nyholm, Kåre, George Reed, and Knud-Erik Sjølin. "LETTERER-SIWE DISEASE." Acta Pathologica Microbiologica Scandinavica 70, no. 4 (2009): 481–500. http://dx.doi.org/10.1111/j.1699-0463.1967.tb01316.x.

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7

Ferreira, Leonardo Mello, Paulo Sergio Emerich, Lucia Martins Diniz, Luciene Lage, and Isabella Redighieri. "Histiocitose de células de Langerhans: doença de Letterer-Siwe - importância do diagnóstico dermatológico em dois casos." Anais Brasileiros de Dermatologia 84, no. 4 (2009): 405–9. http://dx.doi.org/10.1590/s0365-05962009000400013.

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A histiocitose de células de Langerhans é proliferação clonal de células fenotipicamente semelhantes às células de Langerhans. Anteriormente denominada Letterer-Siwe, é a forma mais comum e mais grave dessa enfermidade, acometendo sobretudo crianças até os dois anos de idade. São apresentados dois casos dessa rara doença, diagnosticados após parecer dermatológico, destacando-se seus aspectos mais característicos.

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8

Latifa, Alanazi* Ghada Alhindi Yara Alanazi Sarah Alseneidi Bashayer Alanazi Dalal Alshagha Munira Alghufaily Nada Dammas. "LANGERHANS CELL HISTIOCYTOSIS: STORY OF THE ORPHAN DISEASE BEYOND DERMATOLOGY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 2840–47. https://doi.org/10.5281/zenodo.2555667.

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<em>Langerhans cell histiocytosis (LCH), a rare proliferative disorder of cells that share phenotypic characteristics with dermal Langerhans cells, has long been considered an “orphan,” or neglected disease. Prior to its current designation, LCH was known as Hand–Schuller–Christian disease, Letterer–Siwe disease, or eosinophilic granuloma, which was combined under the umbrella designation of Histiocytosis X. The pathogenesis of LCH has remained unclear since the initial reports approximately 100 years earlier, and gene expression studies have demonstrated that the

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9

Novice, Fred M., Daniel W. Collison, D'Anne M. Kleinsmith, Michael E. Osband, John H. Burdakin, and Ralph J. Coskey. "Letterer-siwe disease in adults." Cancer 63, no. 1 (1989): 166–74. http://dx.doi.org/10.1002/1097-0142(19890101)63:1<166::aid-cncr2820630127>3.0.co;2-a.

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10

Zanuncio, Virginia Vinha, Luciana Rabelo de Carvalho, Antônio Carlos Martins Guedes, Cláudia Márcia Resende Silva, and Bernardo Gontijo. "Case for diagnosis." Anais Brasileiros de Dermatologia 88, no. 6 (2013): 1001–3. http://dx.doi.org/10.1590/abd1806-4841.20132451.

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Langerhans cell histiocytosis is a rare, clinically heterogeneous desease. Since there is considerable clinical overlap among the four described variants (Hand-Schüller-Christian, eosinophilic granuloma, Letterer-Siwe and Hashimoto-Pritzker), the concept of spectral disease applies to this entity. The Hashimoto-Pritzker variant was first described in 1973. Characteristically, it is present at birth or during the first days of life, impairment is limited to the skin and prognosis is favorable with spontaneous resolution. We report a newborn male patient with Hashimoto-Pritzker disease presentin

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11

Natsume, Hiromune, Tetsuya Yamaguchi, Junko Ohsawa, et al. "Splenic infarction in Letterer-Siwe disease." Pediatrics International 47, no. 3 (2005): 329–32. http://dx.doi.org/10.1111/j.1442-200x.2005.02070.x.

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12

DRAKE, STILLMAN. "PER UN ARCHIVIO DELLA CORRISPONDENZA DEGLI SCIENZIATI ITALIANI." Nuncius 5, no. 2 (1990): 221–28. http://dx.doi.org/10.1163/182539190x00075.

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Abstracttitle RIASSUNTO /title Esistono negli Stati Uniti e in Canada cinque lettere autografe di Galileo sconosciute ad Antonio Favaro, insieme a copie contemporanee dei manoscritti galileiani del Compasso, della Cosmografia e delle Meccaniche, con varianti rispetto ai testi pubblicati nelle Opere. L'unico testo completo finora conosciuto della lettera di Galileo a Gallanzone Gallanzoni, del 16 luglio 1611, ed una copia con varianti della lettera del 1615 alla Granduchessa Cristina di Lorena sono attualmente a Toronto, dove si trova anche l'epistolario di Girolamo Magagnati, comprendente alcu

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13

Forrest, E., S. J. Gallacher, D. Hadley, M. Soukop, and I. T. Boyle. "Central Nervous System Histiocytosis X — Imaging and Responses to Chemotherapy." Scottish Medical Journal 38, no. 5 (1993): 148–49. http://dx.doi.org/10.1177/003693309303800507.

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Histiocytosis X is the term first coined by Lichtenstein in 19531 to describe a heterogeneous group of disorders which is considered now to include Hand-Schuller-Christian disease, Letterer-Siwe disease and Eosinophilic Granuloma of bone. Gagel, in 1941, first described involvement of the central nervous system (CNS) in Histiocytosis X2 - in this case the hypothalamus and posterior pituitary were the areas principally affected. CNS involvement outwith these areas is rare, generally difficult to diagnose3, and little information on treatment is available. In this case we describe a man with cra

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14

Shimizu, Tohru, Noriko Fukushima, Yoshiro Ebihara, Tetsutaro Sata, and Yuzo Aoyama. "GIANT CELL PNEUMONIA IN LETTERER-SIWE DISEASE." Pathology International 37, no. 3 (1987): 493–501. http://dx.doi.org/10.1111/j.1440-1827.1987.tb00383.x.

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15

Claudy, A. L., B. Larbre, M. Colomb, V. Levigne, and V. Deville. "Letterer-Siwe disease and subacute monocytic leukemia." Journal of the American Academy of Dermatology 21, no. 5 (1989): 1105–6. http://dx.doi.org/10.1016/s0190-9622(89)70306-6.

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16

Wright, Andrew L., William F. G. Tucker, David N. Slater, and Christine I. Harrington. "Letterer-Siwe disease in the ninth decade." Journal of the American Academy of Dermatology 12, no. 2 (1985): 369–71. http://dx.doi.org/10.1016/s0190-9622(85)80059-1.

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17

Yakovlev, Y. Y., F. K. Manerov, O. I. Andriyanova, et al. "THE CASE OF LANGERHANS CELL HISTIOCYTOSIS (ABT–LETTERER–SIWE DISEASE) IN TWIN GIRLS." Pediatria. Journal named after G.N. Speransky 97, no. 4 (2018): 141–45. http://dx.doi.org/10.24110/0031-403x-2018-97-4-141-145.

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18

Al-Mohannadi, Muneera, Rafie Yakoub, Madiha E. Soofi, Hesham Mahmoud A. Elsabah, and Ragesh Babu Thandassery. "Gastrointestinal: Letterer Siwe disease: An uncommon gastrointestinal presentation." Journal of Gastroenterology and Hepatology 31, no. 6 (2016): 1070. http://dx.doi.org/10.1111/jgh.13293.

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19

Balakrishnan, R., Dipak Ranjan Nayak, and K. Deepak Murty. "Letterer-siwe disease with bilateral temporal bone involvement." American Journal of Otolaryngology 18, no. 1 (1997): 76–79. http://dx.doi.org/10.1016/s0196-0709(97)90054-5.

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20

Jayachandran, S., and N. Balaji. "Langerhans Cell Histiocytosis." World Journal of Dentistry 2, no. 1 (2011): 57–62. http://dx.doi.org/10.5005/jp-journals-10015-1055.

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ABSTRACT Langerhans cell histiocytosis (LCH) is rare unique disorder of the reticuloendothelial system characterized by an abnormal proliferation of histiocytes and eosinophilic leukocytes. Lichtenstein gave the term Histiocytosis X in 1953 to include three clinical varieties; Eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease, which shared some common histologic features and clinical findings. In 1973, the term LCH was introduced as an alternative to histiocytosis X. LCH may manifest orally with single or multiple lesions of the alveolar or basal bone, ulcerated

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21

Saha, Kanu Lal, Bishnu Pada Dey, Md Abul Hasnat Joarder, Mohammad Anamul Haque, and Bishwajit Bhowmik. "Bilateral Langerhans Cells Histiocytosis in the Temporal Bone: A case report." Bangladesh Journal of Otorhinolaryngology 26, no. 1 (2020): 68–72. http://dx.doi.org/10.3329/bjo.v26i1.47956.

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Langerhans cells histiocytosis (LCH) or histiocytosis-X is a rare group diseases that includes three overlapping diseases of Hand-Schuller-Christian disease (HSC), Letterer-Siwe disease (LS)and Eosinophilic granuloma(EG). It results from clonal proliferation of histiocytes having similar morphology and immunophenotype to Langerhans cells in skin and mucosa Though head and neck manifestation is common, isolated simultaneous bilateral temporal bone Langerhans Cell Histiocytosis is an extremely rare presentation. Having same otological menifestations, high resolution CT scan is advocated for earl

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22

Wankhade, VaishaliH, BhagyashreeBabanrao Supekar, TejalDevidas Ghanate, and RajeshPratap Singh. "Successful treatment of an uncommon disorder: Letterer-siwe disease." Indian Journal of Drugs in Dermatology 6, no. 2 (2020): 91. http://dx.doi.org/10.4103/ijdd.ijdd_49_19.

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23

SUDA, Koichi, Masako MITSUMATA, Toshio OYAMA, et al. "Two cases of Letterer-Siwe disease. A cytologic study." Journal of the Japanese Society of Clinical Cytology 25, no. 6 (1986): 1060–64. http://dx.doi.org/10.5795/jjscc.25.1060.

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24

Pant, C., P. N. Madonia, R. Bass та M. Jeroudi. "LANGERHANSʼ CELL HISTIOCYTOSIS: A CASE OF LETTERER-SIWE DISEASE." Journal of Investigative Medicine 55, № 1 (2007): S270. http://dx.doi.org/10.1097/00042871-200701010-00661.

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25

Aldred, M. J., P. J. Crawford, B. L. Chadwick, A. Day, and N. Dallimore. "Precocious tooth eruption and loss in Letterer-Siwe disease." British Dental Journal 165, no. 10 (1988): 367–70. http://dx.doi.org/10.1038/sj.bdj.4806640.

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26

Delgado-Azañero, Wilson, Hiroshi Concha Cusihuallpa, and Victor Calderón Ubaqui. "Remisión espontánea de histiocitosis de células de Langerhans unifocal de la mandíbula." Revista Estomatológica Herediana 18, no. 1 (2014): 35. http://dx.doi.org/10.20453/reh.v18i1.1853.

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La histiocitosis de células de Langerhans, denominada originalmente histiocitosis X, comprende un grupo de desórdenes caracterizados por la proliferación anormal de este tipo de células acompañadas con abundante cantidad de esosinófilos. La enfermedad puede afectar cualquierestructura u órgano del cuerpo ya sea en forma localizada denominada granuloma eosinófilo o en formas sistémicamente diseminadas que dependiendo de la magnitud de las lesiones y edad del paciente reciben el nombre de enfermedad de Hand- Schuller-Christian o Letterer-Siwe. En este trabajo se presenta un caso de histiocitosis

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27

Giovanetti Pontes, Fábio Teixeira, Adelmo Ferreira, Adriano Torres Antonucci, et al. "Histiocitose de células de Langerhans como causa de mielopatia: Relato de caso e revisão da literatura." Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 29, no. 01 (2010): 32–36. http://dx.doi.org/10.1055/s-0038-1625584.

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ResumoHistiocitose de células de Langerhans é uma doença uni ou multifocal que acomete osso, tecido mole ou ambos. Relativamente incomum, abrange entidades clínicas anteriormente conhecidas como doença de Hand-Schüller-Christian, Abt-Letterer-Siwe, Hashimoto-Pritzker, granuloma eosinofílico e histiocitose X. Responsável por menos de 1% dos tumores ósseos, muito raramente leva a acometimento neurológico. Sua etiologia é desconhecida e seu tratamento, controverso. A ocorrência de um caso com comprometimento neurológico nos motivou a este relato. Paciente do sexo feminino, 4 anos de idade, com pr

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28

Erős, Levente. "Over de Holocaust in kleutertaal. De toepassing van didactische aanbevelingen voor holocaustonderwijs in Martine Letteries Kinderen met een ster (2016)." Initium, no. 3 (November 24, 2021): 192–208. http://dx.doi.org/10.33934/initium.2021.3.9.

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Martine Letteries schreef het boek Kinderen met een ster in opdracht van Herinneringscentrum Kamp Westerbork en het verscheen in 2016. Het boek is in Nederland voor kinderen vanaf ongeveer vijf à zes jaar aangeraden waardoor het verhaal een interessant onderzoeksobject blijkt. Als onderzoeksvraag stel ik de vraag ‘Met welke auteurstechnieken maakt Martine Letterie de Holocaust in Kinderen met een ster voor jonge lezers bespreekbaar?’. Hiernaast kijk ik er ook naar in hoeverre de representatie van de Holocaust in Letteries boek in lijn is met de International Holocaust Remembrance Alliance aanb

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29

Gehl, Liana. "The Last Letter. On the Correspondence Between Vladimir Ghika and Jacques Maritain." Studia Universitatis Babeș-Bolyai Theologia Catholica 66, no. 1-2 (2021): 105–33. http://dx.doi.org/10.24193/theol.cath.2021.05.

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L’ultima lettera. Sulla corrispondenza fra Vladimir Ghika e Jacques Maritain. Tra il 1920 e il 1945, il Beato Vladimir Ghika e il filosofo francese Jacques Maritain condussero un ricco epistolare. Nonostante le avversità, più di trecentottanta lettere si sono conservate fino ad oggi. Iniziato nei “ruggenti anni Venti”, lo scambio si concluse bruscamente sulla soglia della Seconda Guerra Mondiale. Il presente articolo si concentra sull’ultimo pezzo della corrispondenza: la lettera scritta da Ghika a Maritain il 18 luglio 1945. Dopo averne indagato il contesto e sotteso il significato per le par

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30

Gregory, Anne, and Arnold Bank. "An Interview with Arnold Bank: Designer, Letterer, and Master Calligrapher." Art Education 38, no. 2 (1985): 32. http://dx.doi.org/10.2307/3192842.

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31

Amert, Kay. "Rudolf Koch: Letterer, Type Designer, Teacher. Gerald Cinamon , Hermann Zapf." Papers of the Bibliographical Society of America 96, no. 1 (2002): 123–25. http://dx.doi.org/10.1086/pbsa.96.1.24295947.

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32

Patel, Jigna, Dharmender Jairam, Kajal G. Kansara, Tejasvi Patel, and Bela J. Shah. "Letterer–Siwe disease: a case of multisystem Langerhans cell histiocytosis." Egyptian Journal of Dermatology and Venereology 44, no. 2 (2024): 120–24. http://dx.doi.org/10.4103/ejdv.ejdv_18_23.

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Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is an idiopathic uncommon haematological condition affecting infants and young children but can occur at any age group characterized by clonal proliferation of abnormal Langerhans cells. Langerhans cells express an immunophenotype positive for S100 protein, CD1a and Langerin (CD207). Here we present a case of 2-year-old male patient presented with a multiple raw area associated with oozing, bleeding and crusted lesions were present over scalp, trunk and post-auricular areas. Radiographic examination revealed multiple ost

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33

Kashihara-Sawami, Mari, Yuji Horiguchi, Kouichi Ikai, et al. "Letterer-Siwe disease: Immunopathologic study with a new monoclonal antibody." Journal of the American Academy of Dermatology 18, no. 4 (1988): 646–54. http://dx.doi.org/10.1016/s0190-9622(88)70085-7.

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34

Bouzidi, H., M. Meziane, A. Hatimi, et al. "Maladie de Letterer-Siwe chez l’adulte : à propos d’un cas." Annales de Dermatologie et de Vénéréologie 140 (April 2013): S103. http://dx.doi.org/10.1016/j.annder.2013.01.202.

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35

Appel, James E., J. Scott Kasteler, Vilma C. Fabre, and Jeffrey P. Callen. "NEONATAL LUPUS ERYTHEMATOSUS WITH CUTANEOUS FEATURES OF LETTERER-SIWE DISEASE." Southern Medical Journal 91, Supplement (1998): S24. http://dx.doi.org/10.1097/00007611-199810001-00043.

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36

Pavlovic, Milos, Aleksandra Minic, Lidija Zolotarevski, and Sonja Vesic. "Disseminated crusted papules in a newborn." Vojnosanitetski pregled 63, no. 7 (2006): 681–83. http://dx.doi.org/10.2298/vsp0607681p.

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Background. Congenital self-healing Langerhans cell histiocytosis (Hashimoto-Pritzker disease) is the rarest form of Langerhans cell histiocytosis, usually confined to the skin and/or mucous membranes. Cutaneous eruption is mostly generalized, papular, nodular or vesicular. Despite impressive clinical presentation in a newborn it infrequently spreads to internal organs (which then portends a grave prognosis, indistinguishable from Letterer-Siwe disease). Case report. We presented a full-term newborn, female, 3.3 kg who had a multitude of erythematous and crusted papules, nodules and pseudovesi

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Morgan, Kelli W., and Jeffrey P. Callen. "Self-Healing Congenital Langerhans Cell Histiocytosis Presenting as Neonatal Papulovesicular Eruption." Journal of Cutaneous Medicine and Surgery 5, no. 6 (2001): 486–89. http://dx.doi.org/10.1177/120347540100500605.

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Background: Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare condition which may present at birth or during the neonatal period. It is usually characterized by the eruption of multiple, disseminated, red-brown papules and nodules which may increase in size and number during the first few weeks of life. Systemic signs are usually absent except for occasional mild hepatomegaly. Objective: We present a 3.5-kg male infant who presented at birth with numerous diffuse, erythematous, crusted erosions. He was presumed to have congenital herpes simplex virus (HSV) and was starte

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38

MORIKAWA, Mitsuya, Hatsumi FUJII, Kazuyuki SANDA, Masaru OHASHI, and Haruki Iwamura. "A case of Letterer-Siwe disease surviving 2 years after onset." Skin Cancer 4, no. 1 (1989): 222–25. http://dx.doi.org/10.5227/skincancer.4.222.

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39

Lahraoui, Y., N. Mrani Alaoui, M. A. Dendane, et al. "SFCP P-098 - Maladie de Letterer Siwe : challenge diagnostic et thérapeutique." Archives de Pédiatrie 21, no. 5 (2014): 553. http://dx.doi.org/10.1016/s0929-693x(14)71813-5.

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40

APFELSTADT, ERIC. "CHRISTOPHER COLUMBUS, PAOLO DAL POZZO TOSCANELLI AND FERNO DE RORIZ: NEW EVIDENCE FOR A FLORENTINE CONNECTION." Nuncius 7, no. 2 (1992): 69–80. http://dx.doi.org/10.1163/182539192x00857.

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Abstracttitle RIASSUNTO /title Si ritiene che Paolo dal Pozzo Toscanelli abbia mandato tre lettere in Portogallo tra il 1474 e il 1482: una, comprendente una mappa, indirizzata ad un canonico di Lisbona chiamato Fernando Martins; un'altra, contenente copie della prima lettera e della carta, a Cristoforo Colombo; e una terza ancora a Colombo. Sebbene l'autenticit delle tre lettere sia stata accettata dalla maggior parte degli studiosi colombiani, l'intera corrispondenza stata negata da alcuni, e le due lettere a Colombo da altri. In giuoco almeno una parte della stima per la scoperta del Mondo

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41

Steiner, Quynh-Giao, Luc A. Otten, M. John Hicks та ін. "In vivo transformation of mouse conventional CD8α+ dendritic cells leads to progressive multisystem histiocytosis". Blood 111, № 4 (2008): 2073–82. http://dx.doi.org/10.1182/blood-2007-06-097576.

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Division and proliferation of dendritic cells (DCs) have been proposed to contribute to homeostasis and to prolonged antigen presentation. Whether abnormal proliferation of dendritic cells causes Langerhans cell histiocytosis (LCH) is a highly debated topic. Transgenic expression of simian virus 40 (SV40) T antigens in mature DCs allowed their transformation in vivo while maintaining their phenotype, function, and maturation capacity. The transformed cells were differentiated splenic CD8 alpha–positive conventional dendritic cells with increased Langerin expression. Their selective transformat

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42

Bronstein, M. E., G. A. Melnichenko, A. I. Bukhman, et al. "The case of histiocytosis X (Hand - Schüller – Christian disease) with thyroid gland lesion." Problems of Endocrinology 42, no. 3 (1996): 26–29. http://dx.doi.org/10.14341/probl12040.

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Histiocytosis X, which is a rare disease, combines 3 related but different in clinical manifestation, course and prognosis of the syndrome: eosinophilic granuloma (Taratynovs disease), Hand Schller Christian disease (syndrome) and Letterer Siw disease (syndrome). The clinical picture of Hend Schller Christian disease was first described by Hand in 1893, then by Schller in 1915 and Christian in 1920. The term histiocytosis X was first proposed in 1953 by Liechtenstein, who combined all 3 of the aforementioned diseases under this name. on the basis of the similarity of the clinical picture, the

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Barbosa, Breno, and Paulo Ronaldo Jube Ribeiro. "Surgical Treatment of Langerhans Cell Histiocytosis of Cervical Spine: Case-Report and Systematic Review of Literature." Archives of Pediatric Neurosurgery 7, no. 1 (2025): e2702025. https://doi.org/10.46900/apn.v7i1.270.

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Background: Langerhans cell histiocytosis (LCH) is a rare disease involving the cervical spine. This condition is present firstly in the thoracic spine, commonest, followed by the lumbar spine and cervical spine. In Langerhans cell histiocytosis there is excessive proliferation of pathologic Langerhans cells. It is commonly found in males with a ratio of 2.5:1. The etiology of LCH is unknown. There are three defined entities classified on their severities. Letterer-Siwe disease involves multiple organs, Hand-Schuller-Christian disease presents with bony lesions and endocrine abnormalities, and

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Kohen-Couderc, L., J. P. Vannier, S. Marret, and C. I. Fessard. "P02 La maladie de letterer-siwe. A propos d'un cas à revelation neonatale." Archives de Pédiatrie 2 (January 1995): S117. http://dx.doi.org/10.1016/0929-693x(95)90014-4.

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Rogerson, Ian. "Rudolf Koch: Letterer, Type Designer, Teacher200114Gerald Cinamon. Rudolf Koch: Letterer, Type Designer, Teacher. New Castle, Delaware; London: Oak Knoll Press; The British Library 2000. , ISBN: 0 7123 4659 7 $49.95." Library Review 50, no. 1 (2001): 42–56. http://dx.doi.org/10.1108/lr.2001.50.1.42.14.

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Lopes, Rodolfo, and Gabriele Cornelli. "Platão: Cartas: Carta III." Revista Archai, no. 21 (2017): 283–94. http://dx.doi.org/10.14195/1984-249x_21_9.

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Corvinus, C., P. Bartsch, C. Dehnert, F. J. Herth, and E. Grunig. "Pulmonary hypertension in a patient with Abt-Letterer-Siwe syndrome and episodes of HAPE." European Respiratory Journal 36, no. 5 (2010): 1212–14. http://dx.doi.org/10.1183/09031936.00200409.

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Tsuchiya, H., F. Ishibashi, Masahiro Migita, Shinji Mutoh, and Izumi Akaboshi. "Perirenal mass of Langerhans cell histiocytosis (Letterer-Siwe disease) and percutaneous nephrostomy tube placement." European Journal of Pediatrics 154, no. 2 (1995): 117–19. http://dx.doi.org/10.1007/s004310050259.

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Tsuchiya, Hiroyuki, Fuminari Ishibashi, Masahiro Migita, Shinji Mutoh, and Izumi Akboshi. "Perirenal mass of Langerhans cell histiocytosis (Letterer-Siwe disease) and percutaneous nephrostomy tube placement." European Journal of Pediatrics 154, no. 2 (1995): 117–19. http://dx.doi.org/10.1007/bf01991913.

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Papochieva, Vera E., Dimitrinka S. Miteva, Penka I. Perenovska, and Guergana Petrova. "Langerhans-Cell Histiocytoses - Epidemiology, Classification, Clinical Features, Diagnosis, Complications, Treatment and Prognosis." Journal of Biomedical and Clinical Research 9, no. 1 (2016): 3–16. http://dx.doi.org/10.1515/jbcr-2016-0001.

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Summary Histiocytoses comprise a group of diverse diseases of unknown etiology with various clinical presentation and evolution. The underlying pathology is characterised by accumulation and infiltration of variable numbers of cells of the monocyte-macrophage line in the affected tissues and organs. Histiocytoses are divided into three major classes: Langerhans cell histiocytosis (LCH), non- Langerhans cell histiocytosis, and malignant histiocytic disorders. The term LCH (also known in the past as histiocytosis X) encompasses the following rare diseases: Eosinophilic Granuloma, Hand-Schuller-C

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