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Journal articles on the topic 'Leukaemia Inhibitory Factor Receptor'

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Published: 4 June 2021

Last updated: 5 February 2022

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1

CICHY, Joanna, Stefan ROSE-JOHN та James TRAVIS. "Oncostatin M, leukaemia-inhibitory factor and interleukin 6 trigger different effects on α1-proteinase inhibitor synthesis in human lung-derived epithelial cells". Biochemical Journal 329, № 2 (1998): 335–39. http://dx.doi.org/10.1042/bj3290335.

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Interleukin 6 (IL-6), oncostatin M (OSM) and leukaemia-inhibitory factor (LIF) share a common signal-transducing subunit in each of their receptors and thus mediate an overlapping spectrum of biological activities. Although all of these cytokines stimulate the production of α1-proteinase inhibitor (α1-PI) in hepatocyte-derived cells, only OSM is able to up-regulate levels of this inhibitor in epithelial cells originating from the lung. In this study we characterized human lung-derived epithelial-like HTB58 cells for their ability to synthesize α1-PI after treatment with IL-6, OSM and LIF. The

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2

Schäfer-Somi, S., D. Klein, HB Beceriklisoy, et al. "Uterine Progesterone Receptor and Leukaemia Inhibitory Factor mRNA Expression in Canine Pregnancy." Reproduction in Domestic Animals 44 (July 2009): 109–14. http://dx.doi.org/10.1111/j.1439-0531.2009.01390.x.

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3

Fry, RC. "The effect of leukaemia inhibitory factor (LIF) on embryogenesis." Reproduction, Fertility and Development 4, no. 4 (1992): 449. http://dx.doi.org/10.1071/rd9920449.

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Leukaemia inhibitory factor (LIF) was originally identified as a haemopoetic factor that induced the differentiation of certain myeloid leukaemia cell lines. In contrast to this action, LIF was subsequently shown to inhibit the spontaneous differentiation of murine embryonic stem cells in culture, thus maintaining their pluripotency and ability to contribute to the germline of chimaeric mice. In the mouse, mRNA for LIF is expressed by the endometrial glands of the uterus coincident with the time of blastocyst implantation and receptors have been found on the preimplantation blastocyst. The sig

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4

THIEL, Stefan, Iris BEHRMANN, Andreas TIMMERMANN, et al. "Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor." Biochemical Journal 339, no. 1 (1999): 15–19. http://dx.doi.org/10.1042/bj3390015.

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Leukaemia inhibitory factor (LIF) signals via a heterodimeric receptor complex comprised of the LIF receptor (LIFR) and the interleukin (IL)-6 signal transducer gp130. Upon binding to its cognate receptor LIF is internalized. In this study, we show that the LIFR is endocytosed independently of gp130. By using a heterochimaeric receptor system we identified a dileucine-based internalization motif within the cytoplasmic domain of the LIFR. Our findings suggest that a heterodimeric LIFR/gp130 complex and homodimeric gp130/gp130 complex are endocytosed via distinct internalization signals.

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Hirai, Hiroyuki, Peter Karian, and Nobuaki Kikyo. "Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor." Biochemical Journal 438, no. 1 (2011): 11–23. http://dx.doi.org/10.1042/bj20102152.

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LIF (leukaemia inhibitory factor) is a key cytokine for maintaining self-renewal and pluripotency of mESCs (mouse embryonic stem cells). Upon binding to the LIF receptor, LIF activates three major intracellular signalling pathways: the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3), PI3K (phosphoinositide 3-kinase)/AKT and SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase 2]/MAPK (mitogen-activated protein kinase) pathways. These pathways converge to orchestrate the gene expression pattern specific to mESCs. Among the many signalling events downst

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6

KASZA, Aneta, Krzysztof ROGOWSKI, Witold KILARSKI, et al. "Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells." Biochemical Journal 355, no. 2 (2001): 307–14. http://dx.doi.org/10.1042/bj3550307.

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The effects of the production of two closely related cytokines, oncostatin M (OSM) and leukaemia inhibitory factor (LIF), by astrocytoma cells were investigated using the stable cell line human U373-MG, which expressed and secreted both biologically active polypeptides. The expression of LIF by these cells caused resistance to this cytokine due to loss of the LIF receptor (LIFR), from the cell surface, suggesting its retention. In contrast, cells expressing OSM were stimulated by this cytokine, utilizing an autocrine mechanism, and possessed receptors for OSM, but not LIF, on the cell surface.

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7

Owczarek, C. M., M. J. Layton, D. Metcalf, et al. "Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant." EMBO Journal 12, no. 9 (1993): 3487–95. http://dx.doi.org/10.1002/j.1460-2075.1993.tb06023.x.

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8

ZHANG, Jian-Guo, Catherine M. OWCZAREK, Larry D. WARD, et al. "Evidence for the formation of a heterotrimeric complex of leukaemia inhibitory factor with its receptor subunits in solution." Biochemical Journal 325, no. 3 (1997): 693–700. http://dx.doi.org/10.1042/bj3250693.

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Leukaemia inhibitory factor (LIF) is a polyfunctional cytokine that is known to require at least two distinct receptor components (LIF receptor α-chain and gp130) in order to form a high-affinity, functional, receptor complex. Human LIF binds with unusually high affinity to a naturally occurring mouse soluble LIF receptor α-chain, and this property was used to purify a stable complex of human LIF and mouse LIF receptor α-chain from pregnant-mouse serum. Recombinant soluble human gp130 was expressed, with a FLAG® epitope (DYKDDDDK) at the N-terminus, in the methylotropic yeast Pichia pastoris a

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9

Harvey, M. B., K. J. Leco, M. Y. Arcellana-Panlilio, X. Zhang, D. R. Edwards, and G. A. Schultz. "Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor." Development 121, no. 4 (1995): 1005–14. http://dx.doi.org/10.1242/dev.121.4.1005.

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Several proteinases from different multigene families have been implicated in the uterine invasion required for establishment of pregnancy in some mammals. In this study, the expression of matrix metalloproteinase gelatinase B (MMP-9), urokinase-type plasminogen activator (uPA) and their inhibitors was investigated during early mouse embryo development. Transcripts for tissue inhibitors of metalloproteinases (TIMP-1,-2,-3) and uPA receptor were detected throughout pre- and peri-implantation development whilst MMP-9 and uPA mRNAs were first detected in peri-implantation blastocysts associated w

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10

CHAMBERS, Ian, Alison COZENS, Joanne BROADBENT, et al. "Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5′ untranslated region." Biochemical Journal 328, no. 3 (1997): 879–88. http://dx.doi.org/10.1042/bj3280879.

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The low-affinity leukaemia inhibitory factor receptor (LIF-R) is a component of cell-surface receptor complexes for the multifunctional cytokines leukaemia inhibitory factor, ciliary neurotrophic factor, oncostatin M and cardiotrophin-1. Both soluble and transmembrane forms of the protein have been described and several LIF-R mRNAs have been reported previously. In order to determine the coding potential of LIF-R mRNAs we have isolated and characterized the mouse LIF-R gene. mRNA encoding soluble LIF-R (sLIF-R) is formed by inclusion of an exon in which polyadenylation signals are provided by

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11

Sato, Yoko, Kaoru Yoshida, Shiari Nozawa, et al. "Establishment of adult mouse Sertoli cell lines by using the starvation method." REPRODUCTION 145, no. 5 (2013): 505–16. http://dx.doi.org/10.1530/rep-12-0086.

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Sertoli cells were isolated from the testes of 6-week-old mice and stable Sertoli cell lines with higher proliferation rates were subcloned after starvation of primary cultured cells. After two rounds of this subcloning, 33 subcloned lines were selected on the basis of their proliferation rates. In addition, these subclones were screened according to their phagocytic activity and the characteristics of mature Sertoli cells, such as the expression of androgen receptors (ARs) and progesterone receptors, by using western blotting and immunocytochemical analysis, in addition to their morphology an

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12

Yang, Z.-M., S.-P. Le, D.-B. Chen, K. Yasukawa, and M. J. K. Harper. "Expression patterns of leukaemia inhibitory factor receptor (LIFR) and the gp130 receptor component in rabbit uterus during early pregnancy." Reproduction 103, no. 2 (1995): 249–55. http://dx.doi.org/10.1530/jrf.0.1030249.

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13

Hilton, D. J., N. A. Nicola, and D. Metcalf. "Analysis of the distribution and characteristics of receptors for leukaemia inhibitory factor." Cell Differentiation and Development 27 (August 1989): 10–11. http://dx.doi.org/10.1016/0922-3371(89)90070-1.

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14

De Breuck, S., L. Baeyens, and L. Bouwens. "Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas." Diabetologia 49, no. 1 (2005): 108–16. http://dx.doi.org/10.1007/s00125-005-0079-1.

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15

Vogiagis, D., and LA Salamonsen. "Review: The role of leukaemia inhibitory factor in the establishment of pregnancy." Journal of Endocrinology 160, no. 2 (1999): 181–90. http://dx.doi.org/10.1677/joe.0.1600181.

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Leukaemia inhibitory factor (LIF) is a pleiotrophic cytokine required for blastocyst implantation in mice. Uterine expression of LIF and that of its receptors has been demonstrated in a number of mammalian species indicating that LIF may have widespread importance in the establishment of pregnancy. The variations in the reaction of the uterus in preparation for and during implantation are considerable between species and understanding the differences and similarities assists in the interpretation of how this cytokine functions. Recent studies suggest that reduced endometrial LIF contributes to

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16

HEINRICH, Peter C., Iris BEHRMANN, Gerhard MÜLLER-NEWEN, Fred SCHAPER, and Lutz GRAEVE. "Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway1." Biochemical Journal 334, no. 2 (1998): 297–314. http://dx.doi.org/10.1042/bj3340297.

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The family of cytokines signalling through the common receptor subunit gp130 comprises interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1. These so-called IL-6-type cytokines play an important role in the regulation of complex cellular processes such as gene activation, proliferation and differentiation. The current knowledge on the signal-transduction mechanisms of these cytokines from the plasma membrane to the nucleus is reviewed. In particular, we focus on the assembly of receptor complexes after ligand binding, the activat

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17

Seeneevassen, Lornella, Julie Giraud, Silvia Molina-Castro, et al. "Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer." Cancers 12, no. 8 (2020): 2011. http://dx.doi.org/10.3390/cancers12082011.

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Cancer stem cells (CSCs) present chemo-resistance mechanisms contributing to tumour maintenance and recurrence, making their targeting of utmost importance in gastric cancer (GC) therapy. The Hippo pathway has been implicated in gastric CSC properties and was shown to be regulated by leukaemia inhibitory factor receptor (LIFR) and its ligand LIF in breast cancer. This study aimed to determine LIF’s effect on CSC properties in GC cell lines and patient-derived xenograft (PDX) cells, which remains unexplored. LIF’s treatment effect on CSC markers expression and tumoursphere formation was evaluat

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18

Panni, M. K., J. Atkinson, and M. V. Sofroniew. "Leukaemia inhibitory factor prevents loss of p75-nerve growth factor receptor immunoreactivity in medial septal neurons following fimbria–fornix lesions." Neuroscience 89, no. 4 (1999): 1113–21. http://dx.doi.org/10.1016/s0306-4522(98)00385-6.

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19

THIEL, Stefan, Iris BEHRMANN, Andreas TIMMERMANN, et al. "Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor." Biochemical Journal 339, no. 1 (1999): 15. http://dx.doi.org/10.1042/0264-6021:3390015.

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20

HEINRICH, Peter C., Iris BEHRMANN, Serge HAAN, Heike M. HERMANNS, Gerhard MÜLLER-NEWEN, and Fred SCHAPER. "Principles of interleukin (IL)-6-type cytokine signalling and its regulation." Biochemical Journal 374, no. 1 (2003): 1–20. http://dx.doi.org/10.1042/bj20030407.

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The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection. Besides their functions in inflammation and the immune response, these cytokines play also a crucial role in haematopoiesis, liver and neuronal regeneration, embryonal development and fertility. Dysregulation of IL-6-type cytokine signalling contributes to the onset and maintenance of several diseas

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21

Gardiner, Natalie J., William B. J. Cafferty, Sarah E. Slack, and Stephen W. N. Thompson. "Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury." Journal of Neurochemistry 83, no. 1 (2002): 100–109. http://dx.doi.org/10.1046/j.1471-4159.2002.01101.x.

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22

Denizot, Yves, Valérie Lorgeot, Elisabeth Cornu, and Nathalie Nathan. "PLASMA LEUKAEMIA INHIBITORY FACTOR, INTERLUEKIN 6 AND SOLUBLE INTERLEUKIN 6 RECEPTOR LEVELS DURING CARDIOPULMONARY BYPASS WITH EXTRACORPOREAL CIRCULATION." Cytokine 10, no. 4 (1998): 303–6. http://dx.doi.org/10.1006/cyto.1997.0285.

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23

Heymann, Dominique, Anne Godard, Sylvie Raher, et al. "Leukaemia inhibitory factor (LIF) and oncostatin M (OSM) high affinity binding require additional receptor subunits besides GP130 and GP190." Cytokine 8, no. 3 (1996): 197–205. http://dx.doi.org/10.1006/cyto.1996.0028.

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24

van Eijk, M. J. T., J. Mandelbaum, J. Salat-Baroux та ін. "Preimplantation embryology: Expression of leukaemia inhibitory factor receptor subunits LIFRβ and gp 130 in human oocytes and preimplantation embryos". Molecular Human Reproduction 2, № 5 (1996): 355–60. http://dx.doi.org/10.1093/molehr/2.5.355.

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25

Abir, R. "Immunocytochemical detection and RT-PCR expression of leukaemia inhibitory factor and its receptor in human fetal and adult ovaries." Molecular Human Reproduction 10, no. 5 (2004): 313–19. http://dx.doi.org/10.1093/molehr/gah047.

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26

K. Bhanumathy, Kalpana, Amrutha Balagopal, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Andrew Freywald, and Vincenzo Giambra. "Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia." Cancers 13, no. 2 (2021): 184. http://dx.doi.org/10.3390/cancers13020184.

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Protein kinases constitute a large group of enzymes catalysing protein phosphorylation and controlling multiple signalling events. The human protein kinase superfamily consists of 518 members and represents a complicated system with intricate internal and external interactions. Protein kinases are classified into two main families based on the ability to phosphorylate either tyrosine or serine and threonine residues. Among the 90 tyrosine kinase genes, 58 are receptor types classified into 20 groups and 32 are of the nonreceptor types distributed into 10 groups. Tyrosine kinases execute their

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27

K. Bhanumathy, Kalpana, Amrutha Balagopal, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Andrew Freywald, and Vincenzo Giambra. "Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia." Cancers 13, no. 2 (2021): 184. http://dx.doi.org/10.3390/cancers13020184.

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Protein kinases constitute a large group of enzymes catalysing protein phosphorylation and controlling multiple signalling events. The human protein kinase superfamily consists of 518 members and represents a complicated system with intricate internal and external interactions. Protein kinases are classified into two main families based on the ability to phosphorylate either tyrosine or serine and threonine residues. Among the 90 tyrosine kinase genes, 58 are receptor types classified into 20 groups and 32 are of the nonreceptor types distributed into 10 groups. Tyrosine kinases execute their

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28

Reddy, M. A., B. S. Yang, X. Yue, et al. "Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes." Journal of Experimental Medicine 180, no. 6 (1994): 2309–19. http://dx.doi.org/10.1084/jem.180.6.2309.

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The receptor for macrophage colony stimulating factor (CSF-1), the c-fms gene product, is a key determinant in the differentiation of monocytic phagocytes. Dissection of the human and mouse c-fms proximal promoters revealed opposing roles for nuclear protooncogenes in the transcriptional regulation of this gene. On the one hand, c-ets-1, c-ets-2, and the macrophage-specific factor PU.1, but not the ets-factor PEA3, trans-activated the c-fms proximal promoter. On the other hand c-myb repressed proximal promoter activity in macrophages and blocked the action of c-ets-1 and c-ets-2. Basal c-fms p

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29

Gough, NM, RL Williams, DJ Hilton, et al. "LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells." Reproduction, Fertility and Development 1, no. 4 (1989): 281. http://dx.doi.org/10.1071/rd9890281.

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We have previously characterized, purified and cloned a novel murine and human regulator [leukaemia inhibitory factor, LIF] which induces the differentiation of certain murine and human myeloid leukaemic cells. Recently we have shown that there are specific LIF receptors on murine embryonic stem [ES] and embryonal carcinoma [EC] cells and that purified recombinant LIF can substitute for feeder cells and crude sources of differentiation inhibiting activity [DIA] [such as BRL-cell-conditioned medium] in the maintenance of ES cells in a pluripotential state in vitro. Furthermore, ES cells maintai

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30

Lei, T., ZQ Yang, T. Xia, et al. "Stage-specific Expression of Leukaemia Inhibitory Factor and its Receptor in Rabbit Pre-implantation Embryo and Uterine Epithelium During Early Pregnancy." Reproduction in Domestic Animals 39, no. 1 (2004): 13–18. http://dx.doi.org/10.1046/j.1439-0531.2003.00469.x.

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31

Mohamet, L., J. K. Heath, and S. J. Kimber. "Determining the LIF-sensitive period for implantation using a LIF-receptor antagonist." REPRODUCTION 138, no. 5 (2009): 827–36. http://dx.doi.org/10.1530/rep-09-0113.

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Uteri of Lif null mice do not support embryo implantation. Since deletion of some genes often prevents the survival of null mice to adulthood, we have used a proven inhibitor of leukaemia inhibitory factor (LIF) signalling to identify the precise window of time during which LIF is required in vivo, and assessed the cellular expression of several LIF-associated targets. On day 4 of pregnancy, mice were injected with hLIF-05 (inhibitor) into the uterine lumen, with corresponding volumes of PBS (vehicle) injected into the contralateral horn. On days 5 and 6, the number of implantation sites was r

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32

Eckert, J. "mRNA expression of leukaemia inhibitory factor (LIF) and its receptor subunits glycoprotein 130 and LIF-receptor-beta in bovine embryos derived in vitro or in vivo." Molecular Human Reproduction 4, no. 10 (1998): 957–65. http://dx.doi.org/10.1093/molehr/4.10.957.

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33

Kojima, Kenji, Hideharu Kanzaki, Masazumi Iwai, et al. "Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts." Molecular Human Reproduction 1, no. 5 (1995): 249–53. http://dx.doi.org/10.1093/molehr/1.5.249.

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34

HAMMACHER, Annet, John WIJDENES, Douglas J. HILTON, Nicos A. NICOLA, Richard J. SIMPSON, and Judith E. LAYTON. "Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors." Biochemical Journal 345, no. 1 (1999): 25–32. http://dx.doi.org/10.1042/bj3450025.

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The receptor gp130 is used by the interleukin-6 (IL-6)-type cytokines, which include IL-6 and leukaemia-inhibitory factor (LIF). To investigate the role of the three extracellular membrane-proximal fibronectin-type-III-like (FNIII) modules of gp130 and the related receptor for granulocyte colony-stimulating factor (G-CSFR) in cytokine signal transduction we have transfected into murine myeloid M1-UR21 cells the chimaera (GR-FNIII)gp130, which contains the membrane-proximal FNIII modules of the G-CSFR on a gp130 backbone, and its complement, the chimaera (gp130-FNIII)GR. Whereas the binding aff

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Krüttgen, A., J. Grötzinger, G. Kurapkat, et al. "Human ciliary neurotrophic factor: a structure-function analysis." Biochemical Journal 309, no. 1 (1995): 215–20. http://dx.doi.org/10.1042/bj3090215.

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Ciliary neurotrophic factor (CNTF) promotes survival in vitro and in vivo of several neuronal cell types including sensory and motor neurons. The primary structure of CNTF suggests it to be a cytosolic protein with strong similarity to the alpha-helical cytokine family which is characterized by a bundle of four anti-parallel helices. CNTF exerts its activity via complexation with CNTF receptor (CNTF-R). This complex consists of a CNTF-binding protein (CNTF-R) and two proteins important for signal transduction [gp130 and leukaemia inhibitory factor receptor (LIF-R)]. We have shortened the cDNA

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Eswari, S., G. Sai Kumar та G. Taru Sharma. "Expression of mRNA encoding leukaemia inhibitory factor (LIF) and its receptor (LIFRβ) in buffalo preimplantation embryos produced in vitro: markers of successful embryo implantation". Zygote 21, № 2 (2012): 203–13. http://dx.doi.org/10.1017/s0967199412000172.

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SummaryThe objective of this study was to evaluate the effect of supplementation of recombinant leukaemia inhibitory factor (LIF) in culture media on blastocyst development, total cell number and blastocyst hatching rates and the reverse transcription-polymerase chain reaction analysis of preimplantation buffalo embryos to determine whether they contain the LIF-encoding mRNA and its beta receptor (LIFRβ) genes in different stages of preimplantation buffalo embryos. Cumulus–oocyte complexes retrieved from slaughterhouse buffalo ovaries were matured in vitro and fertilized using frozen buffalo s

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Wånggren, K., P. G. Lalitkumar, F. Hambiliki, B. Ståbi, K. Gemzell-Danielsson, and A. Stavreus-Evers. "Leukaemia inhibitory factor receptor and gp130 in the human Fallopian tube and endometrium before and after mifepristone treatment and in the human preimplantation embryo." MHR: Basic science of reproductive medicine 13, no. 6 (2007): 391–97. http://dx.doi.org/10.1093/molehr/gam013.

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38

de Ruijter-Villani, M., C. Deelen, and T. A. E. Stout. "Expression of leukaemia inhibitory factor at the conceptus–maternal interface during preimplantation development and in the endometrium during the oestrous cycle in the mare." Reproduction, Fertility and Development 28, no. 10 (2016): 1642. http://dx.doi.org/10.1071/rd14334.

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Leukaemia inhibitory factor (LIF) plays a critical role in blastocyst development and implantation in several species. The present study investigated mRNA and protein expression for LIF, as well as the low-affinity LIF receptor (LIFR) and interleukin-6 signal transducer (IL6ST), in equine endometrium, trophoblast and histotroph during early pregnancy and in the endometrium during the oestrous cycle. Endometrial LIF mRNA expression was upregulated after Day 21 of pregnancy, whereas LIF immunoreactivity increased in the endometrium on Day 28. Expression of LIF mRNA in the yolk sac membrane incre

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Verma, Arjun, Nishant Banait, Pradeep Suryawanshi, and Reema Garegrat. "Neonatal Schwartz-Jampel syndrome type II: a rare case of peripheral origin of neonatal hypertonia." BMJ Case Reports 14, no. 7 (2021): e240397. http://dx.doi.org/10.1136/bcr-2020-240397.

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Neonatal Schwartz-Jampel syndrome type II is a rare and severe form of genetic disorder. Different from the classical appearance in infancy, neonatal presentation involves respiratory and feeding difficulties, along with characteristic pursed appearance of the mouth, myotonia, skeletal dysplasia and severe fatal hyperthermia. The clinical spectrum of this syndrome is so wide that it easily baffles with more common differentials. In this case report, a neonate born to third-degree consanguineous marriage with previous two abortions presented with respiratory difficulty, severe hyperthermia and

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40

Saha, Piyali, Ghungroo Saraswat, Pratip Chakraborty, Sayani Banerjee, Bikas C. Pal, and Syed N. Kabir. "Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage." REPRODUCTION 144, no. 5 (2012): 633–45. http://dx.doi.org/10.1530/rep-11-0423.

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The tubers ofPueraria tuberosahave folkloric repute as emmenagogue. The n-BuOH fraction of the ethanolic extract of tubers exhibits significant antifertility activity in laboratory animals. The present investigation explored the active principle(s) of the tuber extract with reference to contragestive effects in rats and probed the possible mechanism of action. Bioactivity-guided fractionation identified puerarin as the major constituent that exerted pregnancy-terminating effects. Oral administration of puerarin at ≥300 mg/kg per day for days (D) 1–2 post-coitus resulted in complete implantatio

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Kogan, Inna, Dafna Chap, Ron Hoffman, Elena Axelman, Benjamin Brenner, and Yona Nadir. "JAK-2 V617F mutation increases heparanase procoagulant activity." Thrombosis and Haemostasis 115, no. 01 (2016): 73–80. http://dx.doi.org/10.1160/th15-04-0320.

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SummaryPatients with polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) are at increased risk of arterial and venous thrombosis. In patients with ET a positive correlation was observed between JAK-2 V617F mutation, that facilitates erythropoietin receptor signalling, and thrombotic events, although the mechanism involved is not clear. We previously demonstrated that heparanase protein forms a complex and enhances the activity of the blood coagulation initiator tissue factor (TF) which leads to increased factor Xa production and subsequent activation of the

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ALTHOFF, Katja, Jürgen MÜLLBERG, Dorthe AASLAND, et al. "Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins." Biochemical Journal 353, no. 3 (2001): 663–72. http://dx.doi.org/10.1042/bj3530663.

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Although regulated ectodomain shedding affects a large panel of structurally and functionally unrelated proteins, little is known about the mechanisms controlling this process. Despite a lack of sequence similarities around cleavage sites, most proteins are shed in response to the stimulation of protein kinase C by phorbol esters. The signal-transducing receptor subunit gp130 is not a substrate of the regulated shedding machinery. We generated several chimaeric proteins of gp130 and the proteins tumour necrosis factor α (TNF-α), transforming growth factor α (TGF-α) and interleukin 6 receptor (

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Modrić, T., A. A. Kowalski, M. L. Green, R. C. M. Simmen та F. A. Simmen. "Pregnancy-dependent Expression of Leukaemia Inhibitory Factor (LIF), LIF Receptor-β and Interleukin-6 (IL-6) Messenger Ribonucleic Acids in the Porcine Female Reproductive Tract". Placenta 21, № 4 (2000): 345–53. http://dx.doi.org/10.1053/plac.1999.0493.

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Charnock-Jones, D. S., A. M. Sharkey, P. Fenwick, and S. K. Smith. "Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time." Reproduction 101, no. 2 (1994): 421–26. http://dx.doi.org/10.1530/jrf.0.1010421.

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Gouin, François, Séverine Couillaud, Mireille Cottrel, Anne Godard, Norbert Passuti, and Dominique Heymann. "PRESENCE OF LEUKAEMIA INHIBITORY FACTOR (LIF) AND LIF-RECEPTOR CHAIN (gp190) IN OSTEOCLAST-LIKE CELLS CULTURED FROM HUMAN GIANT CELL TUMOUR OF BONE. ULTRASTRUCTURAL DISTRIBUTION." Cytokine 11, no. 4 (1999): 282–89. http://dx.doi.org/10.1006/cyto.1998.0429.

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Aasland, Dorthe, Birgit Oppmann, Joachim Grötzinger, Stefan Rose-John, and Karl-Josef Kallen. "The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex 1 1Edited by M. Yaniv." Journal of Molecular Biology 315, no. 4 (2002): 637–46. http://dx.doi.org/10.1006/jmbi.2001.5282.

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Kojima, Kenji, Hideharu Kanzak, Masazumi Iwai, et al. "Molecular interactions during pregnancy: Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts." Human Reproduction 10, no. 7 (1995): 1907–11. http://dx.doi.org/10.1093/oxfordjournals.humrep.a136205.

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Kumar, Rahul, Raquel Pereira, Julian Niemann, et al. "The Role of the Lipid Raft-Associated Protein Flotillin-2 during Development and Progression of Myeloid Leukaemia." Blood 134, Supplement_1 (2019): 2921. http://dx.doi.org/10.1182/blood-2019-122670.

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Introduction The role of the bone marrow (BM) microenvironment (BMM) for the regulation of leukaemic stem cells (LSC) and their respective interplay is slowly being elucidated, but knowledge about how membrane structures or adhesion molecules on leukaemia cells may, specifically, interact with the BMM leading to regulation of leukemia cell maintenance and proliferation is limited. Flotillin (flot)-1 and -2 are highly conserved, ubiquitously expressed proteins localised in lipid microdomains in cellular membranes. These dynamic microdomains can serve as platforms for signal transduction, endocy

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Guo, Donglin, Fang Zhou, Dongdong Chen та ін. "Involvement of IRAKs and TRAFs in anti-β2GPI/β2GPI-induced tissue factor expression in THP-1 cells". Thrombosis and Haemostasis 106, № 12 (2011): 1158–69. http://dx.doi.org/10.1160/th11-04-0229.

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SummaryOur previous study has shown that Toll-like receptor 4 (TLR4) and its signalling pathway contribute to anti-β2-glycoprotein I/β2-glycoprotein I (anti-β2GPI/β2GPI)-induced tissue factor (TF) expression in human acute monocytic leukaemia cell line THP-1 and annexin A2 (ANX2) is involved in this pathway. However, its downstream molecules have not been well explored. In this study, we have established that interleukin-1 receptor-associated kinases (IRAKs) and tumour necrosis factor receptor-associated factors (TRAFs) are crucial downstream molecules of anti-β2GPI/β2GPI-induced TLR4 signalin

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Platzbecker, Uwe, Nicole Georgi, Christian Thiede, Gerhard Ehninger, and Thomas Illmer. "The Role of Expression of FLICE and FLICE-Inhibitory Protein Isoforms in Acute Myeloid Leukemia." Blood 106, no. 11 (2005): 2758. http://dx.doi.org/10.1182/blood.v106.11.2758.2758.

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Abstract One possibility of the execution of cell death is due to the interaction of ligands with their specific death receptors. The death-receptor pathway via FAS, tumor-necrosis factor receptor 1 (TNF-R1) and TNF-related apoptosis inducing ligand (TRAIL)-receptors has been shown to be involved in apoptosis induction by cytotoxic agents in acute myeloid leukaemia (AML). Upon ligation the primary executioner of these pathways is named FLICE (caspase 8). The FLICE-inhibitory-protein (FLIP) consists of two isoforms (FLIP long and FLIP short) and can be recruited to the death inducing signaling

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