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Dissertations / Theses on the topic 'Leukemia Chemotherapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Palle, Josefine. "Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9189.

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<p>Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.</p><p>In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML.</p><p>The aims of the studies were to correlate the results of the analysis to biological and clinical parameters and to identify subgroups of AML with specific drug sensitivity profil

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2

Masquelier, Michèle. "Leukemia chemotherapy : experimental studies on pharmacological optimisation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-046-X/.

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3

Kwok, Suet-kei Gladys. "The effectiveness of a chemotherapy educational programme (CEP) for Leukaemia and Lymphoma patients." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972937.

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4

O'Connor, Brian 1961. "Studies towards the synthesis of the novel antileukemic agent CI-920 and the addition of cuprates to vinyltriphenylphosphonium bromide : a synthesis of 1,5-disubstituted 1Z,4Z-pentadienes." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75443.

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A new method for the preparation of 1,5-disubstituted-1Z,4Z-pentadienes by the addition of alkenyl cuprates to vinyltriphenylphosphonium bromide followed by an aldehyde is described. This method is used for the syntheses of 6Z,9Z-heneicosadiene and 15,15-(diethyldithio)-13S-t-butyldiphenylsilyloxy-6Z,9Z,11E-pentadecatriene. Syntheses of $(-)$-(5R)-argentilactone and (+)-(5R)-goniothalamin are described. Model studies towards the synthesis of the novel antileukemic agent CI-920 were carried out.

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5

李富榮 and Foo-wing Lee. "Pharmacokinetics of homoharringtonine in Chinese leukemia patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31209233.

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6

Fuentes, Gari Maria. "A mathematical model of cell cycle heterogeneity for personalizing leukemia chemotherapy." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/26301.

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Acute myeloid leukemia is a type of blood cancer characterized by an excessive build-up of immature blood cells in the bone marrow and blood streams. As a result, healthy stem cells become space- and resource-limited, and do not produce enough functional cells for the body to operate normally. Treatment is required immediately, consisting of intensive chemotherapy. Chemotherapy dosage and schedule are derived from established protocols which do not account for patient-specific and disease-specific heterogeneity. Over- or under- dosage are thus common; a more rational and personalized approach

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7

Kam, Kevin, and 甘季燐. "Therapeutic potential of demethylation agents and histone deaceytlase inhibitors in NK-cell lymphoma and leukemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011564.

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8

Gregory, Bradley Barnes Battaglini Claudio L. "In-hospital individualized prescriptive exercise intervention for acute leukemia patients undergoing chemotherapy." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,678.

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Thesis (M.A.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment for the degree of Master of Arts in the Department of Exercise and Sport Science (Exercise Physiology)." Discipline: Exercise and Sports Science; Department/School: Exercise and Sport Science.

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9

Frost, Britt-Marie. "Chemotherapy in Childhood Acute Lymphoblastic Leukemia : In vitro cellular drug resistance and pharmacokinetics." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2664.

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<p>The aims of the studies described in this thesis were to investigate the pharmacokinetics of and cellular resistance to chemotherapy as causes of treatment failure in childhood acute lymphoblastic leukemia (ALL).</p><p>Leukemic cells from 370 children with newly diagnosed ALL were tested by the Fluorometric Microculture Cytotoxicity Assay to measure their resistance to each of ten standard cytotoxic drugs. In the high-risk group, increased in vitro resistance to each of the drugs dexamethasone, etoposide and doxorubicin was associated with a worse clinical outcome. Combining the results for

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10

Landier, Wendy. "Predictors of Non-Adherence to Oral Chemotherapy in Children with Acute Lymphoblastic Leukemia." Diss., University of Hawaii at Manoa, 2010. http://hdl.handle.net/10125/22058.

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Overall survival for pediatric patients with acute lymphoblastic leukemia (A.L.L.) treated with contemporary therapy now exceeds 85%; however, approximately 20% will experience relapse. Since A.L.L. is the most common malignancy in children, relapsed patients comprise a large proportion of the total number of children with cancer. The prognosis for long-term survival following relapse is generally poor; thus, relapsed A.L.L. is a significant contributor to cancer-related mortality in children. Poor adherence to oral medication is a substantial problem in contemporary health care and may contr

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11

Kwok, Suet-kei Gladys, and 郭雪琪. "The effectiveness of a chemotherapy educational programme (CEP) for Leukaemia and Lymphoma patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972937.

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12

Hui, Pui-yan, and 許珮茵. "The combined effect of Chinese medicinal extract polysaccharide peptide (PSP) and the chemotherapeutic agents-cytarabine, doxorubicinand etoposide in human leukemic cells and normal human T-lymphocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B27776311.

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13

Larery, Angela R. D. "Hierarchical neuropsychological functioning in pediatric survivors of acute lymphoblastic leukemia." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc3949/.

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Acute lymphocytic leukemia (ALL) is one of the most common types of pediatric cancers. Improvements in treatment within the last 20 years have resulted in reduced mortality and a greater focus upon quality of life. Several researchers have documented neuropsychological impairments in children following treatment for ALL; however, there have not been any comparative studies documenting differences in neuropsychological functioning based upon treatment modality despite the documented effects of radiation therapy and combined radiation/chemotherapy upon the developing brain. In addition, past stu

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14

Tada, Kohei. "Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia." Kyoto University, 2015. http://hdl.handle.net/2433/202797.

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15

Moleski, Maria. "Intellectual and mathematical functioning as impacted by central nervous system prophylactic chemotherapy for acute lymphoblastic leukemia." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/284158.

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Acute lymphoblastic leukemia (ALL), the most common childhood cancer, is currently survivable in approximately 70 percent of cases. Better therapeutic regimes are responsible for improved survival rates, and therapy has been refined throughout the past 30 years to reflect the balance struck between effective treatment and possible adverse side effects. Current treatment protocols for standard-risk patents usually consist of either intrathecal (IT) or intravenous (IV) chemotherapy, or both. Chemotherapy without cranial radiation therapy (CRT) is a relatively new form of treatment, and no consen

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16

Tsutsumi, Ikuyo. "Impact of oral voriconazole during chemotherapy for acute myeloid leukemia and myelodysplastic syndrome: a Japanese nationwide retrospective cohort study." Kyoto University, 2020. http://hdl.handle.net/2433/245837.

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17

Finn, Nnenna Adimora. "Role of redox systems in doxorubicin metabolism and doxorubicin-mediated cell signaling: a computational analysis." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41149.

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Insensitivity to chemotherapy is an ongoing issue in cancer treatment, one that appears to be highly dependent on patient-specific variations. It has been shown clinically that while a subset of patients will successfully respond to a particular chemotherapeutic regimen, there exists another subset of patients who when exposed to the same course of therapy will remain resistant to treatment or exhibit signs of relapse after treatment has been administered. This discrepancy raises interesting questions regarding the role that patient-specific variations play in controlling the efficacy of chemo

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18

Haylock, David Norman. "Ex vivo expansion of human haemopoietic progenitor cells." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phh4181.pdf.

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"December 2001." Includes bibliographical references (leaves 178-225) Focuses on the ex vivo growth of human haemopoietic progenitor cells with the objective of defining culture conditions for generating myeloid post-progenitor cells for therapy

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19

Tinsley, Sara Marie. "A Comparison of Quality of Life between Intense and Non-Intense Treatment for Patients with Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5786.

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Acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) are hematologic malignancies that occur most frequently in the sixth and seventh decades of life. Both disorders are associated with a poor prognosis, with median survival of one year or less. An overall five-year survival rate for both disorders, regardless of treatment, is less than 10%. A primary goal of treatment is to improve quality of life (QOL) because cure is improbable. The purpose of this longitudinal cohort study was to compare QOL between groups, intensive, non-intensive therapy, and supportive care. The sam

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20

Ristic, Marko. "ROS/SUMO relationship in the chemotherapeutic treatment of Acute Myeloid Leukemia." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT047.

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Les leucémies aiguë myéloïde (LAM) sont un groupe d’hémopathies malignes, dont le traitement est généralement composé de deux génotoxiques : la cytarabine (Ara-C) et la daunorubicine (DNR). Nous avons montré que l’Ara-C et la DNR induisent la déconjugaison rapide de SUMO (Small Ubiquitin-related Modifier) de ses protéines cibles. Cette deSUMOylation est dûe à l'inactivation des enzymes E1 et E2 de SUMOylation par les espèces réactives de l'oxygène (ROS) produites par l’Ara-C et la DNR et est impliquée dans l'activation de l'apoptose. En outre, cet axe ROS/SUMO est anergisé dans les LAM chimior

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21

Kuss, Bryone Jean. "Molecular and gene expression studies of the genes involved in the breakpoints of the inv(16) leukaemias." Title page, abstract and contents only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phk972.pdf.

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22

Larery, Angela R. D. McGill Jerry C. "Hierarchical neuropsychological functioning among pediatric survivors of acute lymphoblastic leukemia." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3949.

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23

Russell, Kathy, Marion Slack, Janet Cooley, and Kelly Mathews. "Impact of a Specialty Pharmacy-Based Oral Chemotherapy Adherence Program on Patient Adherence." The University of Arizona, 2016. http://hdl.handle.net/10150/614015.

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Class of 2016 Abstract<br>Objectives: Patient medication adherence is a basic requirement for treating chronic myelogenous leukemia (CML) with oral tyrosine kinase inhibitors (TKIs). When imatinib adherence rates are less than 80 or 90 percent, major and complete molecular responses, respectively, do not happen. The purpose of this study was to determine the effect of a real-time medication monitoring (RTMM) reminder system adherence program on the medication possession ratio (MPR). Methods: This analytic study was a retrospective cohort study and used data extracted from chart reviews for pa

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24

Frank, Morgan Caroline, and Morgan Caroline Frank. "Prevention and Improvement of Cognitive Deficits in Childhood Acute Lymphoblastic Leukemia (All) Survivors Treated With Chemotherapy: Evidence-Based Information For Parents." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/621919.

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This thesis summarizes what is known about the cognitive changes in childhood acute lymphoblastic leukemia (ALL) survivors treated with chemotherapy, as well as associated risk factors and intervention strategies. An educational pamphlet was developed compiling this information to serve as anticipatory guidance for parents of children diagnosed with ALL. ALL is a cancer of the blood and bone marrow and is the most common pediatric malignancy, accounting for 25% of cancers in children under 15 years of age. Treatments are extremely successful, with survival rates of 90% for children young

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25

Koishi, Seiji. "Biomarkers in long survivors of Pediatric acute lymphoblastic leukemia Patients : late effects of cancer chemotherapyに関する研究". Kyoto University, 2000. http://hdl.handle.net/2433/151425.

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26

Fung, Kwong-lam, and 馮廣林. "The effect of microtubule targeting chemotherapeutic agents on bone marrow derived mesenchymal stromal cells and its interaction withacute lymphoblastic leukemia blasts." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085660.

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27

Kozlowski, Piotr. "Prognostic factors, treatment and outcome in adult acute lymphoblastic leukemia : Population-based studies in Sweden." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-47424.

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Acute lymphoblastic leukemia (ALL) has poor prognosis in older/elderly adults and in high-risk/relapsed disease. Recommended treatment of ALL was evaluated (study I-IV). Data was obtained from the Swedish Acute Leukemia registries and from patient records. I. We assessed ALL relapse treatment and outcome in 76 patients aged 15-65 years (y). Complete remission (CR) was achieved in 50/71 patients (70%). Of them, 29 underwent allogeneic hematopoietic stem cell transplantation (hSCT). Five year overall survival (OS) was 15%, but close to 50% in 19 patients <35y after hSCT. II. We studied outcom

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28

Figliolia, Suzana Luzia Coelho. "Fatores de risco para mucosite bucal em pacientes com leucemia linfóide aguda submetidos a diferentes protocolos de tratamento." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/25/25136/tde-22062007-141538/.

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A mucosite bucal está entre as principais complicações decorrentes do tratamento antineoplásico em pacientes com leucemia linfóide aguda (LLA). Entre os fatores de risco para sua ocorrência destacam-se a idade, o gênero e a leucometria inicial, além das drogas quimioterápicas com comprovada ação estomatotóxicas. O objetivo deste estudo foi investigar a prevalência e os fatores de risco para a mucosite bucal em pacientes com LLA submetidos a diferentes protocolos de tratamento quimioterápicos. Um total de 169 prontuários clínicos de pacientes oncológicos pediátricos submetidos a diferentes prot

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29

Kizhakkekkara, Vadukoot Anish. "Targeting the Stress Response to ROS: Design and Development of Novel and Selective Anti-cancer Agents." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460652535.

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30

Löfgren, Christina. "Pharmacological and clinical studies of new ways to improve cytostatic treatment of acute myelocytic leukemia : in vitro and in vivo studies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-183-0/.

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31

Grohmann, Theresa, Melanie Penke, Stefanie Petzold-Quinque, Susanne Schuster, Sandy Richter, Wieland Kiess, and Antje Garten. "Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway." Elsevier, 2018. https://ul.qucosa.de/id/qucosa%3A38590.

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NAMPT (Nicotinamide phosphoribosyltransferase) catalyses the rate-limiting step in the NAD biosynthesis from nicotinamide and thereby regulates the activity of NAD-dependent enzymes. Cancer cells are highly dependent on NAD for energy and DNA repair processes and are assumed to be more susceptible to an inhibition of NAD synthesis than non-transformed cells. We aimed to investigate whether or not inhibition of NAMPT with its specific inhibitor FK866 can sensitize leukemia cells for chemotherapeutic agents. NAMPT protein abundance, enzymatic activity and NAD concentrations were significantly hi

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32

Javier, Jose Emmanuel F. "Increased TGF-beta Signaling Drives Different Hematopoietic Disease Outcomes following Stress Hematopoiesis." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1617109578665394.

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33

Soares, Andrea Ferreira. "Avalia??o cl?nica e microbiol?gica da mucosa oral de crian?as com leucemia linfobl?stica aguda, submetidas ? a??o profil?tica do gluconato de clorexidina A 0,12%." Universidade Federal do Rio Grande do Norte, 2004. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17106.

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Made available in DSpace on 2014-12-17T15:32:17Z (GMT). No. of bitstreams: 1 AndreaFS.pdf: 584148 bytes, checksum: 1823dffba43267f037cb07f5493ee540 (MD5) Previous issue date: 2004-12-20<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Regarding the morbidity potential of oral complications in patients with leukemia, it evaluated the cl?nical and microbiologic changes of oral mucosal in children with LLA, with age range of O to 15 years old, undergone the chemotherapy antineoplastic and for the use prophylactic of chlorhexidine gluconate 0,12% during ten days, that was utiliz

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34

Pillay, Looventharee. "The development of a nutrition support protocol for children with Acute Lymphoblastic Leukemia (ALL) : twenty case studies from Sheikh Khalifa Medical City, Abu Dhabi, UAE." University of the Western Cape, 2017. http://hdl.handle.net/11394/5636.

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Magister Scientiae (Nutrition Management) - MSc(NM)<br>Acute lymphocytic leukemia (ALL) is the most common type of childhood cancer accounting for approximately 25% of cancers diagnosed in children less than 20 years of age. It originates in the bone marrow and prevents the normal manufacture of red blood cells, white blood cells and platelets. A poor nutritional status is frequently observed in children with ALL at the time of diagnosis and during treatment which may result in protein energy malnutrition if nutrition intervention is delayed. This retrospective study aims to assess the nutriti

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35

Viana, Simone Santana. "Anticorpos vacinais virais em crianças portadoras de Leucemia Linfóide Aguda após quimioterapia." Universidade Federal de Sergipe, 2009. https://ri.ufs.br/handle/riufs/3681.

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The role of vaccination in children, who received chemotherapy for malignancies, including acute lymphoblastic leukemia (ALL), remains controversial. Both the disease and treatment affect the immune system. Changes may occur by neutropenia, leading to immediate risk of bacterial and fungal infections, loss protective levels of antibody by previous immunizations, as well as the questionable efficacy of revaccination. Therefore, different approaches are applied in several countries and the best vaccination schedule is not well defined yet. Moreover, the existing recommendations, mainly built on

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36

Melo, Carolina Pereira de Souza 1979. "Padronização da RMN para determinação precoce da resistência à quimioterapia na leucemia linfóide aguda infantil." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316897.

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Orientadores: José Andrés Yunes, Ana Carolina de Mattos Zeri<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituo de Biologis<br>Made available in DSpace on 2018-08-19T21:00:30Z (GMT). No. of bitstreams: 1 Melo_CarolinaPereiradeSouza_D.pdf: 3404055 bytes, checksum: 57f3eb2b6199d017aab0f03512317367 (MD5) Previous issue date: 2012<br>Resumo: O uso intensivo e combinado de diferentes quimioterápicos tem permitido a cura de 70-80% das leucemias linfóides agudas (LLA) da infância. A intensidade e o uso das drogas são adaptados ao risco de recaída dos pacientes, aferido ao diagnóstic

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37

Abreu, Ana Isabel Alves. "Manifestações orais em crianças em tratamento oncológico." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5130.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária<br>Dados da Organização Mundial de Saúde (OMS) de 2012 demonstram que a incidência de cancro a nível mundial tem vindo a aumentar, e referem cerca de 14 milhões de novos casos por ano. O cancro infantil representa 0,5% a 4,6% de todos os cancros, variando a sua taxa de incidência entre 50 a 200 novos casos, por milhão de crianças, em todo o mundo. Nos países ocidentais, os protocolos terapêuticos antineoplásicos atualmente empregues mel

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38

Silva, D?bora Sunaly Leite da. "Avalia??o das habilidades neurocognitivas em crian?as e adolescentes sobreviventes da Leucemia Linfoide Aguda - LLA." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17557.

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Made available in DSpace on 2014-12-17T15:39:05Z (GMT). No. of bitstreams: 1 DeboraSLS_DISSERT.pdf: 842349 bytes, checksum: edfd0464865223ade8a750fe80589852 (MD5) Previous issue date: 2014-07-11<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>The present study investigated the impact of the treatment modalities of Acute Lymphoblastic Leukemia on neurocognitive abilities of children and adolescents survivors, aged between 6 and 16 years of age, accompanied in pediatric oncology sectors of public health services in the cities of Campina Grande-PB and Natal-RN. The study inc

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Rech, Ângela. "Influência da punção lombar traumática e da quimioterapia intratecal na sobrevida de pacientes pediátricos com leucemia linfocítica aguda." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2005. http://hdl.handle.net/10183/4146.

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Introdução e Objetivos: O sistema nervoso central (SNC) é o um sítio freqüente de recaída na criança com leucemia linfocítica aguda (LLA). Existe evidência de que a punção lombar traumática (PLT) pode representar um risco adicional de recaída no SNC quando ocorre inoculação de blastos no liqüido céfalorraquidiano (LCR). Este estudo tem por objetivo determinar se a ocorrência da PLT ao diagnóstico afeta o prognóstico de pacientes com essa patologia. Material e Métodos: Setenta e sete pacientes com diagnóstico de LLA, tratados entre 1992 a 2002, foram incluídos na análise. Quimioterapia intratec

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40

Silveira, André Bortolini 1987. "Inibição da via PI3K na leucemia linfoide aguda T pediátrica = resposta à quimioterapia e implicações clínicas = PI3K inhibition in childhood T-cell acute lymphoblastic leukemia: response to chemotherapy and clinical implications." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317454.

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Orientadores: José Andrés Yunes, Nilson Ivo Tonin Zanchin<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-24T06:00:33Z (GMT). No. of bitstreams: 1 Silveira_AndreBortolini_D.pdf: 16883235 bytes, checksum: e0759c48520d471791a5272349e1a837 (MD5) Previous issue date: 2013<br>Resumo: A via PI3K está frequentemente hiperativada em células primárias de leucemia linfoide aguda T (LLA-T) pediátrica, característica previamente associada à resistência a glucocorticoides. Pacientes cujas células leucêmicas apresentam mutações em PTEN,

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41

Alcanfôr, Brasília Mendes de Melo. "Anticorpos contra sarampo e rubéola em crianças portadoras de Leucemia Linfóide Aguda." Universidade Federal de Sergipe, 2009. https://ri.ufs.br/handle/riufs/3676.

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The Acute Linfoid Leukemias (ALL) represent one third of oncologic disease in childhood. Children, at the end of treatment, can present endangerment of immune response, secondary to the illness itself and the chemotherapy, so that it is important the evaluation of humoral immunity against vaccine antigens, with the purpose to establish suitable vaccination protocols. Despite being controlled by vaccination, there are registers of imported cases of measles in Brazil, originating of Europe and Asia, with risk of re-introduction of the illness, as well as recent outbreak of rubella in brazilian t

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Mendonça, Cristiano de Queiroz. "Comportamento da pressão ocular em pacientes pediátricos tratados para Leucemia Linfoblástica Aguda e Linfoma não Hodgkin." Universidade Federal de Sergipe, 2014. https://ri.ufs.br/handle/riufs/3885.

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Introduction:Acute Lymphoid Leukemia (ALL) is the most frequent cancer in young people and, if analyzed together with Non-Hodgkin Lymphoma (NHL), we find that they are responsible for at least one third of all cases of childhood cancer. Present-day therapeutic protocols include high doses of glucocorticoids (GC), drugs associate with high potential for elevating intraocular pressure (IOP) and, consequently provoking damage to the fibers of the optic nerve fibers, a pathology classified as cortisone glaucoma. In genetically susceptible patients, ocular hypertension normally occurs some weeks in

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43

Pereira, Michelle Miranda. "Avaliação da fluência verbal e da memória verbal em pacientes pediátricos com leucemia." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5170/tde-01112018-124708/.

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Objetivo: avaliar as habilidades cognitivo-linguísticas de crianças diagnosticadas com leucemia linfoide aguda durante o tratamento quimioterápico. Método: estudo clínico transversal observacional. Formaram o grupo pesquisa (GLL) 18 crianças com idades entre 7 anos e 10 anos e 11 meses, com diagnóstico de leucemia linfoide aguda e em tratamento quimioterápico, que não apresentavam síndromes genéticas, alterações neurológicas e/ou auditivas, não haviam realizado radioterapia e/ou transplante de medula óssea. Foi coletado grupo controle (GC), formado por 18 crianças hígidas, pareadas ao grupo pe

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Delgado, Irene. "Neurocognitive Sequelae of Pediatric Cancers: A Prospective Study of Late Effects." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/280.

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Nearly 80% of children treated for cancer are expected to survive, but not without cost. Survivors face unprecedented challenges associated with long-term consequences of treatment, also called late effects. Approximately half of children treated for cancer are at risk for experiencing cognitive late effects, which typically emerge several years post diagnosis. The nature and extent of cognitive late effects appear to be developmental and related to patient, disease, and treatment variables. However, the relationships between these variables is not well understood because there have been few

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Abrisqueta, Costa Pau. "Tratamiento de primera línea con rituximab combinado con fludarabina, ciclofosfamida y mitoxantrone (RFCM) y mantenimiento con rituximab en pacientes con leucemia linfática crónica." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/283529.

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La leucemia linfática crónica (LLC) es la leucemia más frecuente en la edad adulta en los países occidentales, y se caracteriza por la acumulación y proliferación de linfocitos clonales B maduros CD5+ en la sangre, médula ósea, y ganglios linfáticos. La mediana de supervivencia de los pacientes es de alrededor de 10 años aunque su curso clínico es heterogéneo. Durante varias décadas el tratamiento de esta enfermedad se había basado en el empleo de agentes alquilantes como el clorambucilo, en los análogos de la purinas, o en la asociación de ambos, como la combinación de fludarabina y ciclofosf

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Fernandez, Solène. "Microenvironnement médullaire et résistance à la Midostaurine dans les leucémies aiguës myéloïdes FLT3-ITD Identification de cibles thérapeutiques par criblage génomique fonctionnel." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0281.

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Les leucémies aiguës myéloïdes (LAM) sont des hémopathies malignes agressives. Environ 30% des patients présentent des mutations ITD (Internal tandem reapeat) affectant le récepteur tyrosine kinase FLT3. Ces mutations sont associées à des résistances et à un taux de rechute important au cours des chimiothérapies (Aracytine + Anthracyclines). Des thérapies ciblées utilisant des inhibiteurs de tyrosine kinase (ITK) tels que la Midostaurine ont permis d’améliorer la survie des patients. Malgré cela, le traitement des LAM, reste un véritable défi en raison des rechutes persistantes. Caractériser l

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Marchioro, Mariana Kliemann. "Estudo de utilização de medicamentos em uma unidade de oncologia pediátrica de um hospital universitário de Porto Alegre." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/101511.

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O câncer pediátrico é raro em números absolutos, porém quando comparado às incidências em adultos vem apresentando aumento nas taxas de incidência, exigindo um preparo do sistema de saúde para acompanhamento. Este acompanhamento não pode ser igual ao do adulto, visto que crianças possuem diferenças fisiológicas nas diferentes faixas etárias pediátricas. Sendo assim, estudos de utilização de medicamentos são importantes nesta população, a fim de promover o uso racional dos mesmos, bem como, garantir seu uso seguro e uma terapêutica eficaz. O presente estudo tem por objetivo avaliar as prescriçõ

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Labiad, Yasmine. "Contribution de l’approche transcriptomique dans la physiopathologie et le traitement des hémopathies malignes." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4068.

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L’objectif général de cette thèse a été de mettre en évidence la contribution de l’approche transcriptomique dans la physiopathologie et le traitement des hémopathies malignes. En particulier, comment la technologie des microarrays nous a aidée à étudier diverses problématiques en onco-hématologie.Dans la première partie, notre objectif était d’étudier les cellules Natural killer (Nk) chez les patients atteints de leucémie aiguë myéloïde (LAM). Nous avons comparé la signature transcriptomique des cellules Nk de patients LAM à celle des cellules Nk de sujet sains et suggéré que le facteur de tr

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Morice, Pierre-Marie. "Evaluation de la déficience de la recombinaison homologue et de la réponse des tumeurs ovariennes aux inhibiteurs de PARP grâce à l'utilisation de modèles de culture 3D en vue du développement d'un test prédictif Identifying eligible patients to PARP inhibitors: from NGS-based tests to promising 3D functional assays Automated scoring for assessment of RAD51-mediated homologous recombination in patient-derived tumor organoids of ovarian cancers Risk of myelodysplastic syndrome and acute myeloid leukemia related to PARP inhibitors: a combined approach using a safety meta-analysis of placebo randomized controlled trials and the World Health Organization's pharmacovigilance database The long non-coding RNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC414.

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Chaque année, plus de 150 000 décès sont associés aux cancers épithéliaux de l’ovaire dans le monde, notamment en raison du développement d’une résistance à la chimiothérapie. Environ la moitié de ces cancers présentent des altérations moléculaires provoquant une déficience de la réparation de l’ADN par recombinaison homologue (HRD) qui les sensibilise à l’action des inhibiteurs de la protéine PARP (PARPi). A ce jour, il n’existe pas de test capable d’appréhender le phénotype HRD dans sa globalité, limitant ainsi l’accès à ces traitements. Dans ce contexte, nous avons entrepris de mettre au po

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Masters, Geoffrey John. "Unscheduled interruptions to chemotherapy and high white blood cell counts during chemotherapy increase the risk of relapse in children with acute lymphoblastic leukaemia." Master's thesis, 2005. http://hdl.handle.net/1885/151543.

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