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1

Kenton, Charlotte. Human T-cell leukemia/lymphoma virus (HTLV), January 1982 through September 1984, 234 citations. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1985.

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2

Symposium, Takamatsu no Miya Hi Gan Kenkyū Kikin International. Retroviruses in human lymphoma/leukemia: Proceedings of the 15th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1984. Japan Scientific Societies Press, 1985.

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3

Watanabe, Toshiki, and Takuya Fukushima, eds. Adult T-cell Leukemia/Lymphoma. Springer Japan, 2017. http://dx.doi.org/10.1007/978-4-431-56523-9.

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4

Ramahi, Tarik Mustafa. The rearrangement of the immunoglobulin and T-cell receptor genes in chronic myelogenous leukemia /by Tarik Mustafa Ramahi. s.n.], 1987.

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5

Aswald, Jorg M. Intracellular cytokine analysis in T-cells of patients with chronic myeloid leukemia. National Library of Canada, 2002.

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6

Essex, Myron. Selected abstracts on viral etiology of human cancer.: Human T-cell leukemia viruses. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1986.

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7

Blood cancers: Hearing before a subcommittee of the Committee on Appropriations, United States Senate, One Hundred Seventh Congress, first session, special hearing, June 21, 2001, Washington, DC. U.S. G.P.O., 2002.

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8

Mar, Pearl. Analysis of clonality and lineage of leukemic cell populations and monitoring of bone marrow transplantation using in situ hybridization and blotting methods. GSF-Forschungzentrum für Umwelt Und Gesundheit, 1991.

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9

Bone marrow diagnosis in clinical practice. Johns Hopkins University Press, 1989.

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10

Cerhan, James R., Claire M. Vajdic, and John J. Spinelli. The Non-Hodgkin Lymphomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0040.

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The non-Hodgkin lymphomas (NHL) are a heterogeneous group of over forty lymphoid neoplasms that have undergone a major redefinition over the last twenty-five years, in part due to advances in immunology and genetics as well as implementation of the WHO classification system. NHLs are considered clonal tumors of B-cells, T-cells, or natural killer (NK) cells arrested at various stages of differentiation, regardless of whether they present in the blood (lymphoid leukemia) or lymphoid tissues (lymphoma). In the United States, the age-standardized NHL incidence rate (per 100,000) doubled from 1973
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11

(Adapter), B. Fruet, P. Colling (Adapter), S. Michaelis (Editor), G. Burg (Editor), J. Feit (Editor), and W. Kempf (Editor), eds. Cutaneous Lymphomas: Unusual Cases 2. Steinkopff-Verlag Darmstadt, 2006.

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12

Adult T-cell Leukemia/Lymphoma. Springer, 2017.

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13

Watanabe, Toshiki, and Takuya Fukushima. Adult T-cell Leukemia/Lymphoma. Springer, 2018.

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14

Roman, Eve, Alexandra Smith, and Lorelei Mucci. Leukemias. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676827.003.0028.

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Leukemias are a diverse group of acute and chronic haematological malignancies, that account for 2% to 3% of cancers globally. Recent advances in molecular biology and therapy have transformed the landscape for several leukemia subtypes changing some, but by no means all, from rapidly fatal diseases to treatable conditions with a good prognosis. In general, however, this progress has not been matched by new aetiological insights. Albeit accounting for a relatively small proportion, genetic predisposition syndromes such as neurofibromatosis, Li-Fraumeni and Trisomy 21, have the biggest impact i
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15

Foss, Francine. T-Cell Lymphomas. Humana Press, 2012.

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16

Foss, Francine. T-Cell Lymphomas. Humana, 2016.

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17

Tcell Lymphomas. Humana Press, 2012.

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18

Moriuchi, Hiroyuki. Human T-cell Lymphotropic Virus. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190604813.003.0010.

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Human T-cell lymphotropic virus type 1 (HTLV-1), a human retrovirus that infects an estimated 10–20 million people worldwide, has endemic foci in Japan, West and Central Africa, the Caribbean, Central and South America, and Melanesia. Also, it is the etiological agent of a lymphoproliferative malignancy, adult T-cell leukemia/lymphoma (ATLL), as well as chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 can be transmitted vertically, sexually, or by blood-borne transmission. ATLL occurs in approximately 5% of carriers who are infec
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19

Baracka, Cheryl Anne. Characterization of the association of reovirus serotype 3 with EL-4 lymphoma and L1210 leukemia cells. 1991.

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20

Modeling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus Type I. National Cancer Institute, Office of Cancer Communications, 1988.

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21

Sugamura, Kazuo, ed. Two Decades of Adult T Cell Leukemia and HTLV-1 Research (Gann Monographs on Cancer Research). Karger, 2003.

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22

1952-, Rosen Steven T., ed. Cutaneous t-cell lymphoma: A guide for the community oncologist. CMP Medica, 2006.

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23

Sangster, Robert Norman. Rearrangement and expression of the T cell receptor genes in thymic leukemia cells and functional T cells. 1986.

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24

Mathieson, Alister Mark. Selective cytotoxicity of gammadelta T cells for chronic myeloid leukemia (CML). 2007.

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25

Kaspers, G. J. L., 1963-, Pieters R, and Veerman A. J. P, eds. Drug resistance in leukemia and lymphoma II. Harwood Academic Publishers, 1997.

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26

Drexler, Hans G. The Leukemia-Lymphoma Cell Line Factsbook. Academic Press, 2000.

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27

Drexler, Hans G. The Leukemia-Lymphoma Cell Line Factsbook. Academic Press, 2000.

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28

Peter, Gale Robert, Juttner Christopher, and Henon P. R, eds. Blood stem cell transplants. Cambridge University Press, 1994.

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29

Kaspers, G. J. L., 1963-, Pieters R, and International Symposium on Drug Resistance in Leukemia and Lymphoma (3rd : 1998 : Amsterdam, Netherlands), eds. Drug resistance in leukemia and lymphoma III. Kluwer Academic/Plenum Press, 1999.

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30

Kaspers, G. J. L., 1963-, Pieters R, Veerman A. J. P, and International Symposium on Drug Resistance in Leukemia and Lymphoma (3rd : 1998 : Amsterdam, Netherlands), eds. Drug resistance in leukemia and lymphoma III. Kluwer Academic/Plenum Publishers, 1999.

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31

Soiffer, Robert J. Stem Cell Transplantation for Hemotologic Malignancies (Contemporary Hematology) (Contemporary Hematology). Humana Press, 2004.

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32

J, Soiffer Robert, ed. Stem cell transplantation for hematologic malignancies. Humana Press, 2004.

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33

J, Soiffer Robert, ed. Stem cell transplantation for hematologic malignancies. Humana Press, 2004.

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34

KAS, GERT-JAN L. Drug Resistance in Leukemia and Lymphoma: The Clinical Value of Laboratory Studies. Taylor & Francis, 1993.

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35

Kaspers, G. J. L., 1963-, ed. Drug resistance in leukemia and lymphoma: The clinical value of laboratory studies. Harwood Academic Publishers, 1993.

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36

G.J.L. Kaspers (Editor), R. Pieters (Editor), and A.J.P. Veerman (Editor), eds. Drug Resistance in Leukemia and Lymphoma III (Advances in Experimental Medicine and Biology). Springer, 1999.

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37

Collins, Graham, and Chris Bunch. Lymphoma. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0289.

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Lymphoma is a cancerous disorder characterized by a clonal proliferation of lymphocytes. There are two broad categories: Hodgkin’s lymphoma, and non-Hodgkin’s lymphoma, with Hodgkin’s lymphoma defined by the presence of Reed–Sternberg cells on histological examination of affected tissue. Within the non-Hodgkin’s lymphomas, there are the much more common B-cell lymphomas and the uncommon T-cell lymphomas. Within the B-cell non-Hodgkin lymphomas, there are clinically aggressive (high-grade) forms and much more indolent (low-grade) forms. This chapter addresses the causes, diagnosis, and manageme
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