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Journal articles on the topic 'Leukocyte migration; Immunosuppressive agents'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

ADAMS, DAVID H., LIAN FU WANG, JAMES M. NEUBERGER, and ELWYN ELIAS. "INHIBITION OF LEUKOCYTE CHEMOTAXIS BY IMMUNOSUPPRESSIVE AGENTS." Transplantation 50, no. 5 (1990): 845–49. http://dx.doi.org/10.1097/00007890-199011000-00020.

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Smith, D. A., G. G. Schurig, S. A. Smith, and S. D. Holladay. "Inhibited Cytotoxic Leukocyte Activity in Tilapia (Oreochromis niloticus) Following Exposure to Immunotoxic Chemicals." International Journal of Toxicology 18, no. 3 (1999): 167–72. http://dx.doi.org/10.1080/109158199225459.

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The measure of the ability of cytotoxic immune cells to target and lyse foreign cells has been widely used as a predictor of im-munosuppression in chemical-exposed rodents. However, the efficacy of this function for predicting immunosuppressive chemical exposure in nonrodent species remains unknown. In the present report, tilapia ( Oreochromis niloticus) were exposed to 9 chemical agents known to inhibit rodent cytotoxic T lymphocyte (CTL) activity in mice, benzo[a]pyrene (B[a]P), 7, 12-dimethylbenzanthracene (DMBA), 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), dimethyl-nitrosamine (DMN), cadm

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Winston, Kevin, Hasan Maulahela, Lusiani Lusiani, Raditya Dewangga, and Lazuardi G. Ilhami. "Current Role of Anti-Integrin Therapy in Inflammatory Bowel Disease." Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy 21, no. 2 (2020): 137–45. http://dx.doi.org/10.24871/2122020137-145.

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Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder with multifactorial etiology. Management of IBD is divided into conventional treatment and new treatment with biologic agents. The first biologic agents used for IBD was tumor necrosis factor (TNF)-inhibitor. However, TNF-inhibitor as a biologic agent has several limitations such as low rate of clinical response and systemic immunosuppressive side effects. Anti-integrin is a recently developed biologic agent which selectively inhibits leukocyte trafficking towards site of inflammation. The inhibition is caused by bl

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4

Pocheć, Ewa, Katarzyna Bocian, Marta Ząbczyńska, Grażyna Korczak-Kowalska, and Anna Lityńska. "Immunosuppressive Drugs Affect High-Mannose/Hybrid N-Glycans on Human Allostimulated Leukocytes." Analytical Cellular Pathology 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/324980.

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N-glycosylation plays an important role in the majority of physiological and pathological processes occurring in the immune system. Alteration of the type and abundance of glycans is an element of lymphocyte differentiation; it is also common in the development of immune-mediated inflammatory diseases. The N-glycosylation process is very sensitive to different environmental agents, among them the pharmacological environment of immunosuppressive drugs. Some results show that high-mannose oligosaccharides have the ability to suppress different stages of the immune response. We evaluated the effe

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Cao, Jing-Yuan, Qing Guo, Ge-Fei Guan, et al. "Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma." Aging 12, no. 2 (2020): 1656–84. http://dx.doi.org/10.18632/aging.102706.

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6

Schnitzler, Johan G., Renate M. Hoogeveen, Lubna Ali, et al. "Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation." Circulation Research 126, no. 10 (2020): 1346–59. http://dx.doi.org/10.1161/circresaha.119.316206.

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Rationale: Patients with elevated levels of lipoprotein(a) [Lp(a)] are hallmarked by increased metabolic activity in the arterial wall on positron emission tomography/computed tomography, indicative of a proinflammatory state. Objective: We hypothesized that Lp(a) induces endothelial cell inflammation by rewiring endothelial metabolism. Methods and Results: We evaluated the impact of Lp(a) on the endothelium and describe that Lp(a), through its oxidized phospholipid content, activates arterial endothelial cells, facilitating increased transendothelial migration of monocytes. Transcriptome anal

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Truong, Nga T. H., Tessa Gargett, Michael P. Brown, and Lisa M. Ebert. "Effects of Chemotherapy Agents on Circulating Leukocyte Populations: Potential Implications for the Success of CAR-T Cell Therapies." Cancers 13, no. 9 (2021): 2225. http://dx.doi.org/10.3390/cancers13092225.

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Adoptive T-cell therapy using autologous T cells genetically modified to express cancer-specific chimeric antigen receptors (CAR) has emerged as a novel approach for cancer treatment. CAR-T cell therapy has been approved in several major jurisdictions for treating refractory or relapsed cases of B-cell precursor acute lymphoblastic leukaemia and diffuse large B-cell lymphoma. However, in solid cancer patients, several clinical studies of CAR-T cell therapy have demonstrated minimal therapeutic effects, thus encouraging interest in better integrating CAR-T cells with other treatments such as co

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Pavlath, G. K., T. A. Rando, and H. M. Blau. "Transient immunosuppressive treatment leads to long-term retention of allogeneic myoblasts in hybrid myofibers." Journal of Cell Biology 127, no. 6 (1994): 1923–32. http://dx.doi.org/10.1083/jcb.127.6.1923.

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Normal and genetically engineered skeletal muscle cells (myoblasts) show promise as drug delivery vehicles and as therapeutic agents for treating muscle degeneration in muscular dystrophies. A limitation is the immune response of the host to the transplanted cells. Allogeneic myoblasts are rapidly rejected unless immunosuppressants are administered. However, continuous immunosuppression is associated with significant toxic side effects. Here we test whether immunosuppressive treatment, administered only transiently after allogeneic myoblast transplantation, allows the long-term survival of the

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Becker, Daniel J., Elizabeth M. Schultz, Jonathan W. Atwell, and Ellen D. Ketterson. "Urban residency and leukocyte profiles in a traditionally migratory songbird." Animal Migration 6, no. 1 (2019): 49–59. http://dx.doi.org/10.1515/ami-2019-0002.

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Abstract Many animals are shifting migrations in response to human activities. In particular, human-induced changes to climate and habitat (e.g., urbanization) likely facilitate animals becoming year-round residents. Because migration can be energetically expensive, shifts to sedentary behavior could minimize energetic demands incurred and any immunosuppressive effects. Residency in urban habitats could also provide abundant resources and allow sedentary animals to invest more in immunity. However, urban habitats could also expose sedentary animals to novel stressors that counter such benefits

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Rossi, Elisa, Francisco Sanz-Rodriguez, Nelida Eleno, et al. "Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration." Blood 121, no. 2 (2013): 403–15. http://dx.doi.org/10.1182/blood-2012-06-435347.

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Abstract Human endoglin is an RGD-containing transmembrane glycoprotein identified in vascular endothelial cells. Although endoglin is essential for angiogenesis and its expression is up-regulated in inflammation and at sites of leukocyte extravasation, its role in leukocyte trafficking is unknown. This function was tested in endoglin heterozygous mice (Eng+/−) and their wild-type siblings Eng+/+ treated with carrageenan or LPS as inflammatory agents. Both stimuli showed that inflammation-induced leukocyte transendothelial migration to peritoneum or lungs was significantly lower in Eng+/− than

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11

Wogensen, L., X. Huang, and N. Sarvetnick. "Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans." Journal of Experimental Medicine 178, no. 1 (1993): 175–85. http://dx.doi.org/10.1084/jem.178.1.175.

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Transgenic expression of interleukin 10 (IL-10) in the islets of Langerhans leads to a pronounced pancreatic inflammation, without inflammation of the islets of Langerhans and without diabetes. A scattered infiltration of macrophages (M pi) precedes localized accumulations of CD4+ and CD8+ T lymphocytes, B lymphocytes, and M pi. This recruitment of inflammatory cells to the pancreas is somewhat surprising, since the biological activities of IL-10 in vitro indicate that IL-10 is a powerful immunosuppressive cytokine. Since endothelial cells play a major role in leukocyte extravasation, we exami

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Roussos Torres, Evanthia T., Dimitrios N. Sidiropoulos, Emily Davis-Marcisak, et al. "Characterization of the immune tumor microenvironment of HER2-positive breast cancer following treatment with entinostat and immune checkpoint inhibition." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15061-e15061. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15061.

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e15061 Background: HER2+ breast cancers are known to be less-immunogenic and associated with low response rates to immune checkpoint inhibitors (ICIs). A combination of immunosuppressive signals that prevent cytotoxic T cells from infiltrating the tumor microenvironment (TME) and, low tumor antigen expression, contribute to immunotherapy resistance in this population. Epigenetic modulators can both reexpress tumor antigens and rewire the immunosuppressive environment. We previously used a histone deacetylase inhibitor, entinostat (ENT), in combination with ICIs to reverse the immunosuppressive

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Kim, Minsoo, Christopher V. Carman, Wei Yang, Azucena Salas та Timothy A. Springer. "The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2". Journal of Cell Biology 167, № 6 (2004): 1241–53. http://dx.doi.org/10.1083/jcb.200404160.

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Dynamic regulation of integrin adhesiveness is required for immune cell–cell interactions and leukocyte migration. Here, we investigate the relationship between cell adhesion and integrin microclustering as measured by fluorescence resonance energy transfer, and macroclustering as measured by high resolution fluorescence microscopy. Stimuli that activate adhesion through leukocyte function–associated molecule-1 (LFA-1) failed to alter clustering of LFA-1 in the absence of ligand. Binding of monomeric intercellular adhesion molecule-1 (ICAM-1) induced profound changes in the conformation of LFA

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Nelson, R. D., N. Shibata, R. P. Podzorski, and M. J. Herron. "Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action." Clinical Microbiology Reviews 4, no. 1 (1991): 1–19. http://dx.doi.org/10.1128/cmr.4.1.1.

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The ability of Candida albicans to establish an infection involves multiple components of this fungal pathogen, but its ability to persist in host tissue may involve primarily the immunosuppressive property of a major cell wall glycoprotein, mannan. Mannan and oligosaccharide fragments of mannan are potent inhibitors of cell-mediated immunity and appear to reproduce the immune deficit of patients with the mucocutaneous form of candidiasis. However, neither the exact structures of these inhibitory species nor their mechanisms of action have yet been clearly defined. Different investigators have

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15

Blázquez-Prunera, A., C. R. Almeida, and M. A. Barbosa. "Human Bone Marrow Mesenchymal Stem/Stromal Cells Preserve Their Immunomodulatory and Chemotactic Properties When Expanded in a Human Plasma Derived Xeno-Free Medium." Stem Cells International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/2185351.

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Due to their immunomodulatory and chemotactic properties, hMSC are being explored to treat immune-related diseases. For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was analysed. Bone marrow-derived hMSC preserved their immunosuppressive and immunostimulatory properties, as observed with in vitro assays with hMSC cocultured with mixed leukocyte reactions or with mitogen-stimulated leukocytes. Moreover, hMSC expanded in xeno-free medium were recrui

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16

Vita, Serena, Simona Gabrielli, Lucia Fontanelli Sulekova, et al. "Malaria in an asylum seeker paediatric liver transplant recipient: diagnostic challenges for migrant population." Journal of Infection in Developing Countries 15, no. 01 (2021): 172–78. http://dx.doi.org/10.3855/jidc.12541.

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Transplanted patients are particularly exposed to a major risk of infectious diseases due to prolonged immunosuppressive treatment. Over the last decade, the growing migration flows and the transplant tourism have led to increasing infections caused by geographically restricted organisms. Malaria is an unusual event in organ transplant recipients than can be acquired primarily or reactivation following immunosuppression, by transfusion of blood products or through the transplanted organ. We report a rare case of Plasmodium falciparum infection in a liver transplanted two years-old African boy

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17

van Kooyk, Y., M. E. Binnerts, C. P. Edwards, et al. "Critical amino acids in the lymphocyte function-associated antigen-1 I domain mediate intercellular adhesion molecule 3 binding and immune function." Journal of Experimental Medicine 183, no. 3 (1996): 1247–52. http://dx.doi.org/10.1084/jem.183.3.1247.

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We have identified amino acid residues within the evolutionarily conserved I domain of the alpha-chain (CD11a) of the leukocyte integrin leukocyte function-associated antigen (LFA) 1 that are critical for intercellular adhesion molecule (ICAM) 3 (CD50) binding. ICAM-3, a ligand of LFA-1, is thought to mediate intercellular adhesion essential for the initiation of immune responses. Using a panel of human/murine I domain chimeras and point mutants, we observed that the Ile-Lys-Gly-Asn motif, located in the NH2-terminal part of the CD11a I domain, is required for ICAM-3 but not ICAM-1 binding. Th

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18

Matsushima, Hironori, Hiroaki Tanaka, Norikatsu Mizumoto, and Akira Takashima. "Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells." Blood 114, no. 1 (2009): 64–73. http://dx.doi.org/10.1182/blood-2009-02-204297.

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Abstract By screening 720 natural compounds in a standard 2-way allogeneic mixed leukocyte reaction assay, we identified a potent immunosuppressive capacity of crassin acetate (CRA), a coral-derived cembrane diterpenoid. CRA efficiently inhibited allogeneic mixed leukocyte reaction as well as antigen-specific activation of CD4 T cells by bone marrow–derived dendritic cells (DCs). With regard to cellular targets, CRA suppressed not only mitogen-triggered T-cell activation, but also lipopolysaccharide-induced DC maturation, indicating dual functionality. Treatment with CRA at nontoxic doses indu

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19

Senyuk, Vitalyi, Dolores Mahmud, Annie L. Oh, Pritesh R. Patel, and Damiano Rondelli. "C75 Fatty Acid Synthesis (FAS) Inhibitor Has Potent Immunosuppressive Activity." Blood 128, no. 22 (2016): 2156. http://dx.doi.org/10.1182/blood.v128.22.2156.2156.

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Abstract Fatty acid synthesis (FAS) or oxidation (FAO) are important regulatory pathways in immune response. In fact, FAS plays a pivotal role in antigen presentation and T cells activation and FAO leads to fatty acid degradation which has been previously shown to regulate hematopoietic stem cell maintenance. Here we hypothesized that FAS can be a new target to suppress T cell alloimmune responses in solid organ or stem cell transplantations. Therefore, we tested if the FAS inhibitor C75 could suppress T cell alloreactivity without impairing normal hematopoiesis. The immuno-suppressive (IS) ef

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20

Muraille, Eric, Fabienne Andris, Bernard Pajak, et al. "Downregulation of Antigen-Presenting Cell Functions After Administration of Mitogenic Anti-CD3 Monoclonal Antibodies in Mice." Blood 94, no. 12 (1999): 4347–57. http://dx.doi.org/10.1182/blood.v94.12.4347.

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Abstract Antibodies against CD3ɛ are widely used as immunosuppressive agents. Although it is generally assumed that these reagents exert their immunomodulatory properties by inducing T-cell deletion and/or inactivation, their precise mechanism of action remains to be elucidated. Using a murine model, we demonstrate in this report that administration of anti-CD3ɛ antibodies causes the migration and maturation of dendritic cells (DC) in vivo, as determined by immunohistochemical analysis. This maturation/migration process was followed by selective loss of splenic DC, which resulted in a selectiv

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Muraille, Eric, Fabienne Andris, Bernard Pajak, et al. "Downregulation of Antigen-Presenting Cell Functions After Administration of Mitogenic Anti-CD3 Monoclonal Antibodies in Mice." Blood 94, no. 12 (1999): 4347–57. http://dx.doi.org/10.1182/blood.v94.12.4347.424k31_4347_4357.

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Antibodies against CD3ɛ are widely used as immunosuppressive agents. Although it is generally assumed that these reagents exert their immunomodulatory properties by inducing T-cell deletion and/or inactivation, their precise mechanism of action remains to be elucidated. Using a murine model, we demonstrate in this report that administration of anti-CD3ɛ antibodies causes the migration and maturation of dendritic cells (DC) in vivo, as determined by immunohistochemical analysis. This maturation/migration process was followed by selective loss of splenic DC, which resulted in a selective inhibit

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Saito, Mikio, Manabu Abe, Tomoyasu Furukawa, et al. "Study on Patients Who Underwent Suspected Diagnosis of Allergy to Amide-Type Local Anesthetic Agents by the Leukocyte Migration Test." Allergology International 63, no. 2 (2014): 267–77. http://dx.doi.org/10.2332/allergolint.13-oa-0653.

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Al Amin, Md, Ishtiaque A. Chowdhury, KMM Mahbub, et al. "Anti-inflammatory and Analgesic Activities of Asteracantha longifolia Nees." Bangladesh Pharmaceutical Journal 15, no. 2 (2012): 171–76. http://dx.doi.org/10.3329/bpj.v15i2.12586.

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The present study was designed to evaluate the analgesic and anti-inflammatory activities of the ethanol extract of whole plant of Asteracantha longifolia Nees (family Acanthaceae) in mice. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate, formalin induced pain and acetic acid-induced writhing test in mice. Anti inflammatory effects were determined by ear swelling induced by croton oil, xyleneinduced ear edema, leukocyte migration induced by carrageenan, cotton pellet-induced granuloma formation. Tramadol (10 mg/kg) and Ibuprofen (100

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Tan, Fang, Flaubert Mbeunkui, Crystal Harris, and Solomon F. Ofori-Acquah. "Mechanisms for Transcriptional Activation of the Human Activated Leukocyte Cell Adhesion Molecule Gene and Its Silencing by Immunosuppressive Toxins." Blood 108, no. 11 (2006): 1637. http://dx.doi.org/10.1182/blood.v108.11.1637.1637.

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Abstract Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a member of the immunoglobulin super-family. It is expressed on the surfaces of activated monocytes, dendritic cells and macrophages. These immune cells use ALCAM through homotypic and heterotypic adhesions to control multiple stages in the inflammatory response. Indeed, anti-ALCAM antibodies and recombinant soluble ALCAM significantly inhibit monocyte transendothelial migration, stabilization of the immunological synapse and dendritic cell-mediated T-lymphocyte proliferation. Despite this significance, there is currently no

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Blaich, Birgit, Rachida Siham BelAiba, Sabine Merl, et al. "Comparative characterization of cellular and molecular anti-restenotic profiles of paclitaxel and sirolimus." Thrombosis and Haemostasis 97, no. 06 (2007): 1003–12. http://dx.doi.org/10.1160/th06-10-0586.

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SummaryPleiotropic anti-restenotic properties of drugs that are eluted from coated stents are critical for efficacy and safety. Little is known about comparative drug properties in appropriate human coronary target cell lines for the two compounds that are utilized on FDA-approved drug-eluting stent (DES) platforms, paclitaxel (PTX) and sirolimus (SRL). Target cell lines that play a pivotal role for the pathogenesis of restenosis and vascular healing include human coronary artery smooth muscle (CASMC) and endothelial cells (CAEC). PTX and SRL inhibited CASMC and CAEC proliferation and migratio

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Kosoff, David, Leigh Ellis, David J. Beebe, and Joshua Michael Lang. "Targeting tumor-associated macrophage (TAM) mediated inhibition of T-cell migration in prostate cancer using epigenetic modifying agents." Journal of Clinical Oncology 38, no. 6_suppl (2020): 166. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.166.

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166 Background: Cytotoxic T lymphocytes (CTLs) perform vital anti-tumor functions and are critical to the efficacy of many anticancer therapies. In prostate cancer, the characteristic paucity of activated CTLs within the tumor microenvironment (TME) may be a key factor in disease progression and likely underlies the limited role for immune checkpoint inhibitors (ICIs) in prostate cancer treatment. In this study, we utilized novel microfluidic technologies to evaluate whether TAMs may be driving the exclusion of T cells from the prostate TME and whether the immunosuppressive functions of TAMs c

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Adhikary, Sabina, Virginia P. Kocieda, Jui-Hung Yen, Ronald F. Tuma, and Doina Ganea. "Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression." Blood 120, no. 18 (2012): 3741–49. http://dx.doi.org/10.1182/blood-2012-06-435362.

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Abstract Administration of cannabinoid receptor 2 (CB2R) agonists in inflammatory and autoimmune disease and CNS injury models results in significant attenuation of clinical disease, and reduction of inflammatory mediators. Previous studies reported that CB2R signaling also reduces leukocyte migration. Migration of dendritic cells (DCs) to various sites is required for their activation and for the initiation of adaptive immune responses. Here, we report for the first time that CB2R signaling affects DC migration in vitro and in vivo, primarily through the inhibition of matrix metalloproteinase

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Saeed, Rubina W., Santosh Varma, Tina Peng-Nemeroff, et al. "Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation." Journal of Experimental Medicine 201, no. 7 (2005): 1113–23. http://dx.doi.org/10.1084/jem.20040463.

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Endothelial cell activation plays a critical role in regulating leukocyte recruitment during inflammation and infection. Based on recent studies showing that acetylcholine and other cholinergic mediators suppress the production of proinflammatory cytokines via the α7 nicotinic acetylcholine receptor (α7 nAChR) expressed by macrophages and our observations that human microvascular endothelial cells express the α7 nAChR, we examined the effect of cholinergic stimulation on endothelial cell activation in vitro and in vivo. Using the Shwartzman reaction, we observed that nicotine (2 mg/kg) and the

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Henriques, Bárbara O., Olívia Corrêa, Elaine Patrícia C. Azevedo та ін. "In VitroTNF-αInhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect ofStryphnodendron adstringensin an Acute Arthritis Model". Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/9872598.

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Stryphnodendronspecies, popularly named “barbatimão,” are traditionally used in Brazil as anti-inflammatory agents. This study aimed to investigate the effect of barbatimão and 11 other species on the production of tumor necrosis factor-alpha (TNF-α) in lipopolysaccharide- (LPS-) stimulated THP-1 cells, as well as their anti-arthritis activity. The extracts ofStryphnodendron adstringens,Stryphnodendron obovatum,Campomanesia lineatifolia, andTerminalia glabrescenspromoted a concentration-dependent inhibition of TNF-α. Mice injected with LPS in the knee joint were treatedper oswith fractions fro

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Bergan, John J., Geert W. Schmid-Schönbein, and Shinya Takase. "Therapeutic Approach to Chronic Venous Insufficiency and its Complications: Place of Daflon® 500 mg." Angiology 52, no. 1_suppl (2001): S43—S47. http://dx.doi.org/10.1177/0003319701052001s06.

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Early manifestations of chronic venous insufficiency (CVI) are edema, hyperpigmentation, and lipodermatosclerosis. Late complications are cutaneous ulceration and delayed healing. The specific hallmarks of this inflammation include CD68-positive infiltration into the dermal tissue, monocytes, and lymphocytes and enhanced endothelial permeability. This may lead to "fibrin cuff" formation. In addition, membrane adhesion molecules are present and cytokine expression is seen. In one experimental model of mesenteric venous hypertension, the inflammatory process was detected in its earliest stages.

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Thivierge, Maryse, Christian Le Gouill, Michel J. Tremblay, Jana Stanková, and Marek Rola-Pleszczynski. "Prostaglandin E2 Induces Resistance to Human Immunodeficiency Virus-1 Infection in Monocyte-Derived Macrophages: Downregulation of CCR5 Expression by Cyclic Adenosine Monophosphate." Blood 92, no. 1 (1998): 40–45. http://dx.doi.org/10.1182/blood.v92.1.40.413k43_40_45.

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The chemokine receptor CCR5 can function as a coreceptor for human immunodeficiency virus-1 (HIV-1) entry into CD4+ T cells and macrophages, especially during the early stages of HIV-1 infection. The regulation of CCR5 expression may affect not only leukocyte migration, but also infectivity by HIV-1 and, therefore, acquired immunodeficiency syndrome (AIDS) pathogenesis. We report here that agents which increase intracellular concentrations of cyclic adenosine monophosphate (cAMP) rapidly downregulate CCR5 gene expression, with consequent loss of CCR5 expression and function in monocytes/macrop

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Cooper, David K. C., H. Iwase, L. Wang, et al. "Bringing Home The Bacon: Update on The State of Kidney Xenotransplantation." Blood Purification 45, no. 1-3 (2018): 254–59. http://dx.doi.org/10.1159/000485163.

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Background: There is a continuing critical shortage of organs from deceased human donors for transplantation, particularly for patients awaiting kidney transplantation. Efforts are being made to resolve the donor kidney shortage by the transplantation of kidneys from genetically-engineered pigs. Summary: This review outlines the pathobiological barriers to pig organ xenotransplantation in primates, which include (i) antibody-dependent complement-mediated rejection, (ii) a T cell-mediated elicited antibody and cellular response, (iii) coagulation dysregulation between pigs and primates, and (iv

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Fabbri, Monica, Silvia Di Meglio, Maria Cristina Gagliani та ін. "Dynamic Partitioning into Lipid Rafts Controls the Endo-Exocytic Cycle of the αL/β2Integrin, LFA-1, during Leukocyte Chemotaxis". Molecular Biology of the Cell 16, № 12 (2005): 5793–803. http://dx.doi.org/10.1091/mbc.e05-05-0413.

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Cell migration entails the dynamic redistribution of adhesion receptors from the cell rear toward the cell front, where they form new protrusions and adhesions. This process may involve regulated endo-exocytosis of integrins. Here we show that in primary neutrophils unengaged αL/β2integrin (LFA-1) is internalized and rapidly recycled upon chemoattractant stimulation via a clathrin-independent, cholesterol-sensitive pathway involving dynamic partitioning into detergent-resistant membranes (DRM). Persistent DRM association is required for recycling of the internalized receptor because 1) >90%

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Wolfram, Dolores, Evi M. Morandi, Nadine Eberhart, et al. "Differentiation between Acute Skin Rejection in Allotransplantation and T-Cell Mediated Skin Inflammation Based on Gene Expression Analysis." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/259160.

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Advances in microsurgical techniques and immunosuppressive medication have rendered transplantation of vascularized composite allografts possible, when autologous tissue is neither available nor sufficient for reconstruction. However, skin rejection and side effects of long-term immunosuppression still remain a major hurdle for wide adoption of this excellent reconstructive technique. Histopathologic changes during acute skin rejection in vascular composite allotransplantation often mimic inflammatory skin disorders and are hard to distinguish. Hence, the identification of diagnostic and thera

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Dharma, Sanam Sahjram, Tara Barone, Sheila Figel, et al. "OTME-21. The role of Glioblastoma associated mesenchymal stem cells in immune suppression." Neuro-Oncology Advances 3, Supplement_2 (2021): ii18. http://dx.doi.org/10.1093/noajnl/vdab070.072.

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Abstract Glioblastoma (GBM) is an aggressive brain cancer, with an overall survival of 14.6 months. The tumor microenvironment in GBM plays major roles in immunosuppression and modulation of the response to therapies. GBM patients with higher levels of mesenchymal stem like cells (G-MSC) show poor overall survival as compared to patients with no/lower G-MSC levels. Our lab found that levels of G-MSC corelate with CD4+ T cells in humans and murine models of GBM, and with immunosuppressive molecules like PTGS2, the gene for cyclooxygenase 2. To investigate the mechanism by which G-MSCs promote i

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Furie, MB, MC Tancinco, and CW Smith. "Monoclonal antibodies to leukocyte integrins CD11a/CD18 and CD11b/CD18 or intercellular adhesion molecule-1 inhibit chemoattractant-stimulated neutrophil transendothelial migration in vitro." Blood 78, no. 8 (1991): 2089–97. http://dx.doi.org/10.1182/blood.v78.8.2089.2089.

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Abstract Intercellular adhesion molecule-1 (ICAM-1) is present on the endothelium and binds to one or more members of the CD11/CD18 family of leukocyte surface integrins. To assess the role of these molecules in mediating chemotaxis of neutrophils across the endothelium, an in vitro model consisting of monolayers of human umbilical vein endothelial cells (HUVEC) grown on amniotic connective tissue was used. Neutrophils placed on the apical sides of these cultures migrated across the endothelium in response to chemoattractants added basally. Monoclonal antibodies (MoAbs) to CD11a, CD11b, and CD

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Furie, MB, MC Tancinco, and CW Smith. "Monoclonal antibodies to leukocyte integrins CD11a/CD18 and CD11b/CD18 or intercellular adhesion molecule-1 inhibit chemoattractant-stimulated neutrophil transendothelial migration in vitro." Blood 78, no. 8 (1991): 2089–97. http://dx.doi.org/10.1182/blood.v78.8.2089.bloodjournal7882089.

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Intercellular adhesion molecule-1 (ICAM-1) is present on the endothelium and binds to one or more members of the CD11/CD18 family of leukocyte surface integrins. To assess the role of these molecules in mediating chemotaxis of neutrophils across the endothelium, an in vitro model consisting of monolayers of human umbilical vein endothelial cells (HUVEC) grown on amniotic connective tissue was used. Neutrophils placed on the apical sides of these cultures migrated across the endothelium in response to chemoattractants added basally. Monoclonal antibodies (MoAbs) to CD11a, CD11b, and CD18 on the

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Bordin, JO, NM Heddle, and MA Blajchman. "Biologic effects of leukocytes present in transfused cellular blood products." Blood 84, no. 6 (1994): 1703–21. http://dx.doi.org/10.1182/blood.v84.6.1703.1703.

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Abstract A considerable literature has accumulated over the past decade indicating that leukocytes present in allogeneic cellular blood components, intended for transfusion, are associated with adverse effects to the recipient. These include the development of febrile transfusion reactions, graft-versus-host disease, alloimmunization to leukocyte antigens, and the immunomodulatory effects that might influence the prognosis of patients with a malignancy. Moreover, it has become evident that such leukocytes may be the vector of infectious agents such as CMV, HTLV-I/II, and EBV as well as other v

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Bordin, JO, NM Heddle, and MA Blajchman. "Biologic effects of leukocytes present in transfused cellular blood products." Blood 84, no. 6 (1994): 1703–21. http://dx.doi.org/10.1182/blood.v84.6.1703.bloodjournal8461703.

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A considerable literature has accumulated over the past decade indicating that leukocytes present in allogeneic cellular blood components, intended for transfusion, are associated with adverse effects to the recipient. These include the development of febrile transfusion reactions, graft-versus-host disease, alloimmunization to leukocyte antigens, and the immunomodulatory effects that might influence the prognosis of patients with a malignancy. Moreover, it has become evident that such leukocytes may be the vector of infectious agents such as CMV, HTLV-I/II, and EBV as well as other viruses. A

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Storb, Rainer, Cong Yu, Todd Barnett, et al. "Stable Mixed Hematopoietic Chimerism in Dog Leukocyte Antigen–Identical Littermate Dogs Given Lymph Node Irradiation Before and Pharmacologic Immunosuppression After Marrow Transplantation." Blood 94, no. 3 (1999): 1131–36. http://dx.doi.org/10.1182/blood.v94.3.1131.415k21_1131_1136.

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Stable mixed donor/host hematopoietic chimerism can be accomplished in dog leukocyte antigen (DLA)-identical littermate dogs given sublethal (200 cGy) total-body irradiation (TBI) before and immunosuppression with mycophenolate mofetil (MMF) and cyclosporine (CSP) after transplant (Blood 89:3048, 1997). Studies were based on the hypothesis that drugs that prevent graft-versus-host disease (GVHD) after transplant also suppress host-versus-graft (HVG) reactions and thereby enhance engraftment. Here, we asked whether pretransplant TBI provided marrow space for the graft to home or caused host imm

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Garcia, Joe G. N., Alexander D. Verin, Maria Herenyiova, and Denis English. "Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration." Journal of Applied Physiology 84, no. 5 (1998): 1817–21. http://dx.doi.org/10.1152/jappl.1998.84.5.1817.

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Increased vascular endothelial cell (EC) permeability and neutrophilic leukocyte (PMN) diapedesis through paracellular gaps are cardinal features of acute inflammation. Activation of the EC contractile apparatus is necessary and sufficient to increase vascular permeability in specific models of EC barrier dysfunction. However, it is unknown whether EC contraction with subsequent paracellular gap formation is required for PMN transendothelial migration in response to chemotactic factors. To test this possibility, we assessed migration of human PMNs across confluent bovine pulmonary arterial EC

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Carbone, Maria Luigia, Pedro Miguel Lacal, Serena Messinese, et al. "Multiple Sclerosis Treatment and Melanoma Development." International Journal of Molecular Sciences 21, no. 8 (2020): 2950. http://dx.doi.org/10.3390/ijms21082950.

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Therapy of multiple sclerosis (MS) with disease-modifying agents such as natalizumab or fingolimod has been associated with the development of cutaneous melanoma. Here we briefly revise literature data and report of a case of a 48-year old woman who developed a melanoma and several atypical naevi after sub sequential treatment with natalizumab (1 year) and fingolimod (7 years). By immunohistochemistry we observed the presence of T cells and leukocyte infiltration as well as of vascular endothelial growth factor (VEGF)-A expression in the patient melanoma biopsy. Then, we analyzed proliferation

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Kubes, Paul. "Polymorphonuclear leukocyte – endothelium interactions: a role for pro-inflammatory and anti-inflammatory molecules." Canadian Journal of Physiology and Pharmacology 71, no. 1 (1993): 88–97. http://dx.doi.org/10.1139/y93-013.

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The movement of polymorphonuclear leukocytes (PMNs) from the mainstream of blood to the extravascular space is a characteristic feature of the inflammatory response. This process requires that the PMN initially contacts the endothelium, then adheres firmly to the vessel wall, and finely migrates out of the microvasculature. Each of these events requires signals or pro-inflammatory molecules that direct the PMN to the potential site of inflammation. These molecules include histamine, which appears to be of importance in the initial recruitment of PMNs, leukotriene B4, which promotes PMN adhesio

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Imamura, Ryoichi, Yoshiko Matsuda, Koichi Tsutahara, Norio Nonomura, and Shiro Takahara. "Impact of Immunoglobulin M-Type Donor-Specific Human Leukocyte Antigen–Antibody Levels in Supernatants from Cultured Peripheral Blood Mononuclear Cells as Predictors of Antibody-Mediated Rejection." Pathogens 9, no. 9 (2020): 733. http://dx.doi.org/10.3390/pathogens9090733.

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Background: Antibody-mediated rejection (AMR) is a crucial barrier in the long-term prognosis of transplant recipients. Methods: Peripheral blood mononuclear cells (PBMCs) were collected from kidney allograft recipients (N = 41) and cultured in vitro for 1 week. Furthermore, the supernatants of the cultured PBMCs were analyzed by Luminex single-antigen beads. Results: Analyses using Luminex single-antigen beads revealed the presence of immunoglobulin (Ig) G donor-specific anti-HLA antibodies (DSAs) was detected in the supernatants of cultured PBMCs collected more frequently than IgM in de novo

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Goralski, Kerry B., Ashley E. Jackson, Brendan T. McKeown, and Christopher J. Sinal. "More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer." International Journal of Molecular Sciences 20, no. 19 (2019): 4778. http://dx.doi.org/10.3390/ijms20194778.

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Chemerin is widely recognized as an adipokine, with diverse biological roles in cellular differentiation and metabolism, as well as a leukocyte chemoattractant. Research investigating the role of chemerin in the obesity–cancer relationship has provided evidence both for pro- and anti-cancer effects. The tumor-promoting effects of chemerin primarily involve direct effects on migration, invasion, and metastasis as well as growth and proliferation of cancer cells. Chemerin can also promote tumor growth via the recruitment of tumor-supporting mesenchymal stromal cells and stimulation of angiogenes

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Fiocchi, Claudio. "New Concepts of Pathogenesis in Inflammatory Bowel Disease." Canadian Journal of Gastroenterology 9, no. 5 (1995): 261–70. http://dx.doi.org/10.1155/1995/847312.

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The precise etiology and mechanisms of inflammatory bowel disease (IBD) are still unclear. Nevertheless, several concepts are gaining acceptance and constitute the basis for a better understanding of its pathogenesis and for improved therapy. The association of Crohn’s disease (CD) and ulcerative colitis (UC) with ‘western’ lifestyle is well recognized, and is considered a reason for the increasing frequency of CD and UC in countries with previously low incidence. Proposed linkages of CD and UC with particular human leukocyte antigen haplotypes suggest a genetic predisposition, but no uniform

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Lu, L., W. A. Rudert, S. Qian, et al. "Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor." Journal of Experimental Medicine 182, no. 2 (1995): 379–87. http://dx.doi.org/10.1084/jem.182.2.379.

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Allografts of the liver, which has a comparatively heavy leukocyte content compared with other vascularized organs, are accepted permanently across major histocompatibility complex barriers in many murine strain combinations without immunosuppressive therapy. It has been postulated that this inherent tolerogenicity of the liver may be a consequence of the migration and perpetuation within host lymphoid tissues of potentially tolerogenic donor-derived ("chimeric") leukocytes, in particular, the precursors of chimeric dendritic cells (DC). In this study, we have used granulocyte/macrophage colon

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Requião-Moura, Lúcio R., Elizabeth De Francesco Daher, Cassio R. Moreira Albino, et al. "Tropical Infections in the Context of Kidney Transplantation in Latin America." American Journal of Tropical Medicine and Hygiene 105, no. 3 (2021): 564–72. http://dx.doi.org/10.4269/ajtmh.19-0926.

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ABSTRACT. Reports on tropical infections among kidney transplant (KT) recipients have increased in recent years, mainly because of the growing number of KT programs located in tropical and subtropical areas, and greater mobility or migration between different areas of the world. Endemic in emerging and developing regions, like most countries in Latin America, tropical infections are an important cause of morbidity and mortality in this population. Tropical infections in KT recipients may exhibit different pathways for acquisition compared with those in nonrecipients, such as transmission throu

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Issekutz, Andrew C., Nancy Lopes, and Thomas B. Issekutz. "Role of interleukin-1 and tumour necrosis factor in leukocyte recruitment to acute dermal inflammation." Mediators of Inflammation 1, no. 5 (1992): 347–53. http://dx.doi.org/10.1155/s0962935192000528.

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The cytokines IL-1 and TNF-α are involved in inflammation and their production is stimulated by various agents, especially endotoxin (LPS). Here, using the human IL-1 receptor antagonist (IL-1RA) and a new monoclonal antibody (mAb 7F11) to rabbit TNF, the role of endogenous IL-l and TNF production in acute (3h) leukocyte (PMNL) recruitment to dermal inflammation in rabbits has been studied. IL-1RA inhibited by 27% the PMNL accumulation in reactions induced by killed Escherichia coli (p < 0.05) but not by LPS. The monoclonal antibody to TNF inhibited by 27% and 38% (p < 0.002) the PMNL ac

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Stashenko, P., R. Teles, and R. D'Souza. "Periapical Inflammatory Responses and Their Modulation." Critical Reviews in Oral Biology & Medicine 9, no. 4 (1998): 498–521. http://dx.doi.org/10.1177/10454411980090040701.

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Periapical inflammatory responses occur as a consequence of bacterial infection of the dental pulp, as a result of caries, trauma, or iatrogenic insult. Periapical inflammation stimulates the formation of granulomas and cysts, with the destruction of bone. These inflammatory responses are complex and consist of diverse elements. Immediate-type responses-including vasodilatation, increased vascular permeability, and leukocyte extravasation-are mediated by endogenous mediators, including prostanoids, kinins, and neuropeptides. Non-specific immune responses-including polymorphonuclear leukocyte a

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