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Relevant bibliographies by topics / Leukocyte telomere length (LTL)

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Academic literature on the topic 'Leukocyte telomere length (LTL)'

Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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Journal articles on the topic "Leukocyte telomere length (LTL)"

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Hassler, Eva, Gunter Almer, Gernot Reishofer, et al. "Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length." Antioxidants 10, no. 12 (2021): 1908. http://dx.doi.org/10.3390/antiox10121908.

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Telomeres are a crucial factor in the preservation of genomic integrity, and an elevated risk for diseases such as cancer and cardiovascular events is related to shortened telomeres. However, telomere deterioration could be caused by factors such as chronic oxidative stress and inflammation, which are promoted by an imbalance among reactive oxygen species (ROS) and antioxidants. In this cross-sectional study, we investigated the relationship between telomeres and oxidative stress. The serum leucocyte telomer length (LTL), serum total antioxidant capacity (TAC) and the total serum lipid panel o

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Khalangot, Mykola, Dmytro Krasnienkov, Alexander Vaiserman, et al. "Leukocyte telomere length is inversely associated with post-load but not with fasting plasma glucose levels." Experimental Biology and Medicine 242, no. 7 (2017): 700–708. http://dx.doi.org/10.1177/1535370217694096.

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Type 2 diabetes mellitus is characterized by shorter leukocyte telomere length, but the relationship between leukocyte telomere length and type 2 diabetes mellitus development is rather questioned. Fasting and post-load glycaemia associated with different types of insulin resistance and their relation with leukocyte telomere length remains unknown. We compared leukocyte telomere length and fasting or post-load glucose levels in persons who do not receive glucose lowering treatment. For 82 randomly selected rural residents of Ukraine, aged 45+, not previously diagnosed with type 2 diabetes mell

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Muniesa, Carlos A., Zoraida Verde, Germán Diaz-Ureña, et al. "Telomere Length in Elite Athletes." International Journal of Sports Physiology and Performance 12, no. 7 (2017): 994–96. http://dx.doi.org/10.1123/ijspp.2016-0471.

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Growing evidence suggests that regular moderate-intensity physical activity is associated with an attenuation of leukocyte telomere length (LTL) shortening. However, more controversy exists regarding higher exercise loads such as those imposed by elite-sport participation.Methods:The authors investigated LTL differences between young elite athletes (n = 61, 54% men, age [mean ± SD] 27.2 ± 4.9 y) and healthy nonsmoker, physically inactive controls (n = 64, 52% men, 28.9 ± 6.3 y) using analysis of variance (ANOVA).Results:Elite athletes had, on average, higher LTL than control subjects, 0.89 ± 0

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Herrmann, Markus, Irene Pusceddu, Winfried März, and Wolfgang Herrmann. "Telomere biology and age-related diseases." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 8 (2018): 1210–22. http://dx.doi.org/10.1515/cclm-2017-0870.

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AbstractTelomeres are the protective end caps of chromosomes and shorten with every cell division. Telomere length has been proposed as a biomarker of biological age and a risk factor for age-related diseases. Epidemiologic studies show an association between leukocyte telomere length (LTL) and mortality. There is solid evidence that links LTL with cardiovascular disease. Short telomeres promote atherosclerosis and impair the repair of vascular lesions. Alzheimer’s disease patients have also a reduced LTL. Telomeres measured in tumor tissue from breast, colon and prostate are shorter than in h

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Hecker, Michael, Brit Fitzner, Kathrin Jäger, et al. "Leukocyte Telomere Length in Patients with Multiple Sclerosis and Its Association with Clinical Phenotypes." Molecular Neurobiology 58, no. 6 (2021): 2886–96. http://dx.doi.org/10.1007/s12035-021-02315-y.

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AbstractAging is a significant factor influencing the course of multiple sclerosis (MS). Accelerated telomere attrition is an indicator of premature biological aging and a potential contributor to various chronic diseases, including neurological disorders. However, there is currently a lack of studies focusing on telomere lengths in patients with MS. We measured the average leukocyte telomere length (LTL) in biobanked DNA samples of 40 relapsing-remitting MS patients (RRMS), 20 primary progressive MS patients (PPMS), and 60 healthy controls using a multiplex quantitative polymerase chain react

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Zimnitskaya, Olga V., Marina M. Petrova, Natalia V. Lareva, et al. "Leukocyte Telomere Length as a Molecular Biomarker of Coronary Heart Disease." Genes 13, no. 7 (2022): 1234. http://dx.doi.org/10.3390/genes13071234.

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Background. This work is a review of preclinical and clinical studies of the role of telomeres and telomerase in the development and progression of coronary heart disease (CHD). Materials and methods. A search for full-text publications (articles, reviews, meta-analyses, Cochrane reviews, and clinical cases) in English and Russian was carried out in the databases PubMed, Oxford University Press, Scopus, Web of Science, Springer, and E-library electronic library using keywords and their combinations. The search depth is 11 years (2010–2021). Results. The review suggests that the relative leukoc

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Gentiluomo, Manuel, Alice Luddi, Annapaola Cingolani, et al. "Telomere Length and Male Fertility." International Journal of Molecular Sciences 22, no. 8 (2021): 3959. http://dx.doi.org/10.3390/ijms22083959.

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Over the past decade, telomeres have attracted increasing attention due to the role they play in human fertility. However, conflicting results have been reported on the possible association between sperm telomere length (STL) and leukocyte telomere length (LTL) and the quality of the sperm parameters. The aim of this study was to run a comprehensive study to investigate the role of STL and LTL in male spermatogenesis and infertility. Moreover, the association between the sperm parameters and 11 candidate single nucleotide polymorphisms (SNPs), identified in the literature for their association

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Poynter, Jenny, Spencer Kelley, Marina Marcato, et al. "Predicted Leukocyte Telomere Length and Risk of Myeloid Neoplasms." Blood 134, Supplement_1 (2019): 1335. http://dx.doi.org/10.1182/blood-2019-131224.

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Background Maintenance of telomere length has long been established to play a role in the biology of cancer, and several lines of evidence suggest that it may be especially important in myeloid malignancy. Measuring leukocyte telomere length (LTL) directly in case control studies is problematic because telomere length is likely to be influenced by the disease process. Recent studies have led to the identification of a robust genetic predictor of LTL, which we have used to compare differences in predicted telomere length in case control studies of myeloid leukemia and myelodysplastic syndromes

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Yeap, Bu B., Jennie Hui, Matthew W. Knuiman, et al. "U-Shaped Relationship of Leukocyte Telomere Length With All-Cause and Cancer-Related Mortality in Older Men." Journals of Gerontology: Series A 76, no. 1 (2020): 164–71. http://dx.doi.org/10.1093/gerona/glaa190.

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Abstract Background Telomeres are essential DNA–protein complexes whose attrition results in cellular dysfunction and senescence. Leukocyte telomere length (LTL) correlates with tissue telomere length, representing a biomarker for biological age. However, its predictive value for mortality risk, and for cardiovascular versus cancer deaths, in older adults remains uncertain. Method We studied 3608 community-dwelling men aged 77.0 ± 3.6 years. Leukocyte telomere length was measured using multiplex quantitative PCR, expressed as amount of telomeric DNA relative to single-copy control gene (T/S ra

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Yim, Onn-Siong, Xing Zhang, Idan Shalev, et al. "Delay discounting, genetic sensitivity, and leukocyte telomere length." Proceedings of the National Academy of Sciences 113, no. 10 (2016): 2780–85. http://dx.doi.org/10.1073/pnas.1514351113.

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In a graying world, there is an increasing interest in correlates of aging, especially those found in early life. Leukocyte telomere length (LTL) is an emerging marker of aging at the cellular level, but little is known regarding its link with poor decision making that often entails being overly impatient. Here we investigate the relationship between LTL and the degree of impatience, which is measured in the laboratory using an incentivized delay discounting task. In a sample of 1,158 Han Chinese undergraduates, we observe that steeper delay discounting, indexing higher degree of impatience, i

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Dissertations / Theses on the topic "Leukocyte telomere length (LTL)"

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Masi, S. "Leukocyte telomere length, inflammation and age-related diseases." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1421262/.

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Background: Aging is a physiological process characterised by a progressive dysfunction in metabolism and impaired tissue repair capacity, eventually leading to organs’ and tissue degeneration. Low-grade inflammation is currently considered the main driver of aging. The measure of telomeres length in peripheral leukocytes (LTL) has been suggested as novel and reliable marker of aging. The aim of this PhD was to investigate the association between (LTL), chronic inflammation and common cardio-metabolic risk factors. Methods: Four studies were conducted: 1) a case-control analysis of 356 cases w

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Wikgren, Mikael. "Telomeres and the brain : an investigation into the relationships of leukocyte telomere length with functional and structural attributes of the brain." Doctoral thesis, Umeå universitet, Psykiatri, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50634.

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Telomeres are the outermost parts of linear chromosomes. They consist of tandemly repeated non-coding short nucleotide sequences (TTAGGG in all vertebrates), in humans spanning over the last 2 to 15 kilobase pairs of the chromosome. Due to the end-replication problem, telomeres shorten with each cellular division. A critically short telomere will trigger the cell to enter a state of cellular senescence or to apoptose. The rate of telomere shortening can be accelerated by factors such as oxidative stress and inflammation. Taken together, this contributed to making telomere length a candidate bi

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Palaniswamy, S. (Saranya). "Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526219295.

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Abstract Vitamin D deficiency, obesity and short telomere length are reported to be associated with increased risk of metabolic diseases and all-cause mortality, through modulation of inflammatory pathways. The season of blood sampling, obesity and physical activity have been identified as determinants of 25-hydroxyvitamin D [25(OH)D], but their association with 25(OH)D2 (D2) and 25(OH)D3 (D3) is still poorly understood. In addition, relationships between 25(OH)D, body mass index (BMI), inflammation, and leukocyte telomere length (LTL) has not been previously established. A better understandin

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Amirfathi, Felix. "Leukocyte telomere length and accelerated aging as predictors for the onset of psychosis." Thesis, 2017. https://hdl.handle.net/2144/26620.

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Leukocyte telomere length is an emerging marker for pathologically accelerated cellular aging. First discovered to be associated with aging-related disorders, such as type 2 diabetes mellitus and cardiovascular disease, in young individuals, leukocyte telomeric degeneration is also garnering growing attention in psychiatric illnesses. Comorbid metabolic symptoms and physiological dysregulation observed in schizophrenia patients imply a plausible association between pathological telomere biology and psychosis. Available data on the relationship between leukocyte telomere length and schizophreni

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Books on the topic "Leukocyte telomere length (LTL)"

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Stoddard, Frederick J., and Robert L. Sheridan. Wound Healing and Depression. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603342.003.0009.

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Depression and wound healing are bidirectional processes for adults and children consistent with the conception of depression as systemic. This systemic interaction is similar to the “bidirectional impact of mood disorder on risk for development, progression, treatment, and outcomes of medical illness” generally. And, evidence is growing that the bidirectional impact of mood disorder may be true for injuries and for trauma surgery. Animal models have provided some support that treatment of depression may improve wound healing. An established biological model for a mechanism delaying wound heal

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Book chapters on the topic "Leukocyte telomere length (LTL)"

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Aviv, Abraham, and Wei Chen. "Exploring Chromosomal Leukocyte Telomere Length Dynamics in the Bogalusa Heart Study." In Evolution of Cardio-Metabolic Risk from Birth to Middle Age:. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-1451-9_1.

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Conference papers on the topic "Leukocyte telomere length (LTL)"

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Balestro, Elisabetta, Davide Biondini, Chiara Rigobello, et al. "Association between leukocyte telomere length (LTL) and functional decline in patients with Idiopathic Pulmonary Fibrosis (IPF) on antifibrotic treatment." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.oa1925.

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Bassig, Bryan, Luoping Zhang, Richard Cawthon, et al. "Abstract 4474: Occupational exposure to benzene and leukocyte telomere length." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4474.

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Weber, Kari A., Christopher M. Heaphy, Edward Giovannucci, Elizabeth A. Platz, and Alan K. Meeker. "Abstract 832: Midlife racial differences In leukocyte telomere length and in associations between modifiable factors and telomere length." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-832.

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Lammertyn, Elise, Dries Martens, Kristine Colpaert, et al. "The association between leukocyte telomere length, telomere attrition and disease severity in cystic fibrosis patients." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.oa4402.

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Yang, Meng, Jennifer Prescott, Elizabeth M. Poole, et al. "Abstract B40: Prediagnosis leukocyte telomere length and risk of ovarian cancer." In Abstracts: AACR Special Conference: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; October 17-20, 2015; Orlando, FL. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3265.ovca15-b40.

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Du, Mengmeng, Jennifer Prescott, Peter Kraft, et al. "Abstract B112: Physical activity, sedentary behavior, and leukocyte telomere length in women." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Oct 22-25, 2011; Boston, MA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1940-6207.prev-11-b112.

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Cigan, Shannon S., Ava C. Kelley, John J. Meredith, et al. "Abstract 874: Predicted leukocyte telomere length and risk of germ cell tumors." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-874.

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Gao, Tao, Junjie Chu, Yinan Zheng, et al. "Abstract C19: Prospective association between blood leukocyte telomere length and cancer incidence and mortality." In Abstracts: Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; Oct 27-30, 2013; National Harbor, MD. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1940-6215.prev-13-c19.

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Smith, A. B., C. K. Garcia, and C. Newton. "Association Between Leukocyte Telomere Length, Complete Blood Count, and Survival in Idiopathic Pulmonary Fibrosis." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1841.

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Weber, Kari A., Christopher M. Heaphy, Corinne E. Joshu, et al. "Abstract 1782: Racial differences in maternal and cord blood leukocyte telomere length and their correlations." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1782.

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Reports on the topic "Leukocyte telomere length (LTL)"

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Pavelites, Joseph J., Steven E. Linnville, and Jeffrey L. Moore. Clinical Associations of Leukocyte Telomere Length in a Cohort of Repatriated Prisoners of War. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada606092.

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