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Dissertations / Theses on the topic 'Leukotrienes'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Qiu, Hong. "Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-056-5/.

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2

Crawley, John Edward. "Leukotrienes." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334790.

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3

Gyllfors, Pär. "Clinical studies of asthma phenotypes focusing on the role of the leukotrienes /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7357-001-X/.

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4

Bäck, Magnus. "Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4846-1/.

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5

Manro, A. "Synthesis of compounds related to leukotrienes." Thesis, University of Salford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381849.

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6

McColl, Shaun Reuss. "Factors affecting the regulation of leukotriene production by neutrophils." Title page, contents and summary only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phm1288.pdf.

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7

Caroppo, V. "EFFECTS OF CYSTEINYL LEUKOTRIENES ON PLATELET ACTIVATION." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/363389.

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Platelet are key players in haemostasis and represent a pivotal link between inflammation, immunity and atherogenesis. Cysteinyl leukotrienes (CysLTs) such as LTC4, LTD4, and LTE4 are potent lipid inflammatory mediators which interact with G protein-coupled receptors, CysLT1R, CysLT2R . However, LTE4, the most stable cystenyl leukotriene, is not putative substrate for these two receptor. Recently have been hypothesized that a third cystenyl leukotreine receptor exists, and a computer modeling suggests P2Y12, receptor for ADP present on platelet surface, as the putative receptor. But GPR99 is

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8

Butler, Paul Ian. "The synthesis and evaluation of potential inhibitors of 5-lipoxygenase." Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357783.

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9

Sousa, Paula T. de. "The synthesis of novel thiophene analogues of leukotrienes." Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317613.

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10

Galton, S. A. "Production of leukotrienes by the porcine pulmonary artery." Thesis, University College London (University of London), 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376096.

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11

Burghardt, Jacqueline Sarah. "Leukotrienes mediate hyperoxia-induced lung damage in newborn rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34743.pdf.

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12

Shah, Duniya. "Involvement of the cysteinyl-leukotrienes in coronary artery disease." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264170.

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13

Coward, Sam M. "The role of leukotrienes in murine sensitisation to aeroallergens." Thesis, University of Sunderland, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402696.

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14

Wikström, Jonsson Eva. "Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2897-5.

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15

Borer, Bennett C. "The synthesis of leukotrienes by organometallic additions to pyrylium salts." Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304686.

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16

Pokhrel, Sabita. "Role of Cysteinyl Leukotrienes in the Regulation of Macrophage Function." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1628859963023725.

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17

Pitt, Christopher M. "An investigation of Angiotensin II : mediated potentiation of contractions of airways." Thesis, Glasgow Caledonian University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311799.

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18

Schröder, Oliver. "Studies on molecular properties and functional regulation of terminal leukotriene C₄ synthases and cysteinyl-leukotriene receptor signalling in human endothelium /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-146-3/.

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19

Reyna, Julianna. "The Role of Cysteinyl Leukotriene Receptor 2 in Thrombocyte Aggregation." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822817/.

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Cysteinyl leukotriene receptor 2, a G-protein coupled receptor known to be expressed and functional on human platelets. However, it seems that upon ligand activation the cysteinyl leukotriene receptor 2 activates a variety of signaling pathways in multiple cell types among different species. Previously, a former laboratory member Vrinda Kulkarni found cysteinyl leukotriene receptor 2 to be expressed on the surface of adult zebrafish thrombocytes. In this work I studied the characteristics of aggregation in adult zebrafish thrombocytes with the knockdown of cysteinyl leukotriene receptor 2. I u

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20

Makker, Himender Kuman. "Mechanisms of exercise-induced asthma." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296269.

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21

Cook, Arlene Jane. "The role of leukotrienes in diseases causing chronic airway obstruction in children." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244248.

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22

Mawhin, Marie-Anne. "Role of neutrophils and leukotrienes in atherosclerotic plaque destabilisation : implication of endotoxemia." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ034/document.

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La déstabilisation de la plaque d’athérosclérose reste de nos jours un problème majeur, malgré les progrès récents dans sa compréhension. Les neutrophiles sont des acteurs puissants de l’immunité innée capables d’altérer les plaques. Un chimio-attractant majeur des neutrophiles, le leucotriène B4, pourrait être un des contributeurs potentiels de la déstabilisation des plaques en particulier dans l’endotoxémie, elle-même associée aux accidents cardiovasculaires. L’objectif de ce travail a été de définir le rôle du leucotriène B4 dans l’attraction des neutrophiles dans la plaque au cours de l’en

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23

Duah, Ernest. "Cysteinyl Leukotrienes and Their Receptors: Potential Roles in Endothelial Function and Cancer." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1469466659.

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24

Kim, Laura Yaunhee. "Optimization of over-expression and purification of human leukotriene C4 synthase mutant R104A for structure-function studies by two-dimensional crystallization and electron crystallography." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45820.

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Membrane proteins are involved in a number of disease pathologies and thus comprise a large number of drug targets. Determination of the high-resolution three-dimensional structure is essential for rational drug design, but several hurdles need to be overcome, primarily the over-expression and purification of said membrane proteins. Human leukotriene C4 synthase (hLTC4S), an 18 kDa integral membrane protein localized in the outer nuclear membrane of eosinophils and basophils, catalyzes the conjugation of LTA4 and reduced glutathione to produce LTC4. LTC4 and its metabolites LTD4 and LTE4 ar

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25

Marr, Kathryn Anne. "Mediators of neutrophil activation and bronchoconstriction in equine chronic obstructive pulmonary disease." Thesis, Royal Veterinary College (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362393.

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26

Svartz, Jesper. "Leukotriene C₄ synthase : studies on oligomerization and subcellular localization /." Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med913s.pdf.

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27

Parmentier, Celine. "Studies on the effect of cysteinyl leukotrienes on human T cell differentiation and function." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/studies-on-the-effect-of-cysteinyl-leukotrienes-on-human-t-cell-differentiation-and-function(4ae23c34-0aa8-4a37-99b1-568a43355e25).html.

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Antigen-specific Th2 cells are central to the pathogenesis of asthma and other allergic diseases. Th2 cells secrete the cytokines IL-4, IL-5 and IL-13, responsible for many of the features of allergic inflammation such as eosinophilia, IgE production and mucus hypersecretion. Cysteinyl leukotrienes (CysLTs) are known potent lipid mediators involved in mucus production, bronchoconstriction and leukocyte migration, and act via the receptors CysLTiR and CysLT2R. Recently, CysLTs have been implicated in Th2 responses in mouse models, although the exact mechanisms are unclear. Preliminary microarra

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28

Canavaci, Adriana Monte Cassiano. "Papel dos leucotrienos durante a infecção experimental de camundongos com \'Trypanosoma cruzi\'." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-27032009-152740/.

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No presente trabalho verificamos o papel dos Leucotrienos na modulação da resposta imune durante a fase aguda da infecção experimental pelo Trypanosoma cruzi, usando como modelo camundongos deficientes da enzima 5-lipoxigenase (5-LOko). Os nossos dados demonstram que camundongos infectados pelo T. cruzi produzem metabólitos do ácido aracdônico como PGE2, LTB4 e LTC4. Comparados aos animais controles, os animais 5-LOko apresenta parasitemia mais tardia e menor, tem menor parasitismo tissular, menor infiltrado de células inflamatórias no coração e musculatura esquelética e apresenta menor taxa d

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29

Garg, Ganesh Prasad. "The gastric antiulcer action of sulphasalazine in cold-restrained rats : implications of leukotriene involvement in stress ulcer aetiology /." [Hong Kong : University of Hong Kong], 1991. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12993128.

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30

Chang, Wei-Chiao. "Ca²+-dependent-regulation of phospholipase A² and leukotriene C⁴ secretion." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670084.

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31

Bossé, Ynuk. "Interactions between fibroblast growth factor 2 and distinct asthma mediators enhance bronchial smooth muscle cell proliferation." Thèse, Université de Sherbrooke, 2006. http://savoirs.usherbrooke.ca/handle/11143/4235.

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Increased bulk of smooth muscle mass around the airways is a typical feature of asthma. Several mediators act in concert or antagonistically to regulate airway smooth muscle (ASM) cell proliferation. This thesis focuses on fibroblast growth factor (FGF)2 and transforming growth factor (TGF)[béta]1 which are known to be sequentially upregulated in the lung following allergic challenge and have recently been shown to synergize together in ASM cell proliferation. Emphasis is put toward the conflicting studies documenting the mitogenic effect of TGF[béta]1 in vitro and to its seemingly potent effe

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32

Trandafir, Cristina Corina. "Study on participation of arginine vasopressin and leukotrienes in development of cerebral vasospasm after subarachnoid hemorrhage." Kyoto University, 2006. http://hdl.handle.net/2433/144056.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第12400号<br>人博第318号<br>新制||人||79(附属図書館)<br>17||D||177(吉田南総合図書館)<br>24236<br>UT51-2006-J392<br>京都大学大学院人間・環境学研究科相関環境学専攻<br>(主査)教授五十棲泰人, 助教授倉橋和義, 教授津田謹輔<br>学位規則第4条第1項該当

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33

Balderramas, Helanderson de Almeida [UNESP]. "Efeito de um inibidor de leucotrienos no processo inflamatório decorrente da infecção por Paracoccidioides brasiliensis em camundongos geneticamnte selecionados." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/89969.

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Made available in DSpace on 2014-06-11T19:24:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-13Bitstream added on 2014-06-13T20:12:17Z : No. of bitstreams: 1 balderramas_ha_me_botfm.pdf: 358097 bytes, checksum: c417b922a0a5cb167dc7ed65911f38d6 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Universidade Estadual Paulista (UNESP)<br>Leucotrienos são mediadores clássicos da resposta inflamatória, descritos como agentes quimiotáticos e reguladores da atividade microbicida de células do sistema imune inato, tendo papel protetor contra diferentes agent

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34

Garg, Ganesh Prasad. "The gastric antiulcer action of sulphasalazine in cold-restrainedrats: implications of leukotriene involvementin stress ulcer aetiology." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B31232206.

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35

Bastos, Rosidete Pereira. "Infecção murina por isolados de Leishmania (Viannia) braziliensis: avaliação da participação de leucotrienos endógenos." Universidade Federal de Goiás, 2008. http://repositorio.bc.ufg.br/tede/handle/tede/4187.

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Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2015-02-13T10:24:59Z No. of bitstreams: 2 Dissertação - Rosidete Pereira de Bastos - 2008.pdf: 938423 bytes, checksum: 1e65715cda59aae81ec161a84d517cb6 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-02-20T11:34:34Z (GMT) No. of bitstreams: 2 Dissertação - Rosidete Pereira de Bastos - 2008.pdf: 938423 bytes, checksum: 1e65715cda59aae81ec161a84d517cb6 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306

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36

SATAKE, TATSUO, KENZO TAKAGI, YASUNOBU NODA, and KENICHI YAMAKI. "Effects of Adrenergic and Cholinergic Agents and Leukotrienes on Mucociliary Transport Force Measured by Using Frog Palate." Nagoya University School of Medicine, 1987. http://hdl.handle.net/2237/17495.

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37

Marques, Mariana Morato. "Leucotrienos como moduladores da imunidade inata a fungos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-12112012-092250/.

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Leucotrienos (LTs) são mediadores lipídicos derivados do ácido araquidônico. Existem evidências que receptores da imunidade inata interagem com receptores para LTs amplificando funções efetoras de macrófagos. Investigamos se LTs modulam a fagocitose e a atividade microbicida via receptores Manose, Dectina -1 e PTX3 em macrófagos alveolares (AMs) e os mecanismos moleculares envolvidos. Nossos resultados mostram que: 1) AMs sintetizam LTs quando fagocitam C. albicans, Zy e Zy-PTX3; 2) LTs potencializam a fagocitose de C. albicans e Zy, mas não de Zy-PTX3. Este efeito dos LTs depende: do reconhec

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38

El-Hakim, Ibrahim El-Sayed M. "Study of the 5-lipoxygenase pathway of arachidonic acid metabolism (leukotrienes) in squamous cell carcinoma of the oral cavity." Thesis, King's College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669048.

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39

Nunes, Gladston Alves [UNESP]. "Efeito de leucotrienos sobre o estado de ativação de macrófagos de camundongos estressados." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/96638.

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Made available in DSpace on 2014-06-11T19:28:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-03Bitstream added on 2014-06-13T19:36:57Z : No. of bitstreams: 1 nunes_ga_me_botfmvz.pdf: 135711 bytes, checksum: ac2deca13d4ed213812621085cb2a3df (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Universidade Estadual Paulista (UNESP)<br>O estresse compreende uma multiplicidade de eventos, envolvendo o sistema imune e ativação do sistema nervoso autônomo, bem como a ativação do eixo hipotálamo-pituitária-adrenal, com conseqüente aumento de catecolaminas e glic

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40

Franco, Luís Henrique. "Papel dos leucotrienos na proteção conferida pela imunização heteróloga BCG/DNA-HSP65 contra tuberculose." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-27102009-174027/.

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A tuberculose é responsável por mais de 2 milhões de mortes ao ano. A imunidade protetora contra a tuberculose está relacionada com a ativação de linfócitos CD4+ e CD8+ produtores de IFN-g, citocina que potencializa os mecanismos microbicidas dos macrófagos para eliminação dos bacilos. Nos últimos anos, o leucotrieno B4 (LTB4) destacou-se como mediador lipídico que participa da imunidade protetora contra diversas infecções, incluindo a tuberculose. Dessa forma, o objetivo desse estudo foi avaliar o papel dos leucotrienos na proteção induzida pela imunização homóloga com DNA-HSP65 ou heteróloga

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41

Campos, Marina Reis de Moura. "Ação dos leucotrienos na fagocitose via receptores Fc e manose em macrófagos alveolares e mecanismos moleculares envolvidos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-21102016-172133/.

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Os leucotrienos aumentam a fagocitose e a atividade microbicida contra uma série de patógenos. Em macrófagos alveolares, LTB4 e LTD4 aumentam a fagocitose via FcγR de modo dependente de PKC. Entretanto, o papel das isoformas específicas da PKC, das MAPK, e da PI3K neste processo, ainda não é conhecido. Além disso, pouco se sabe sobre a importância dos leucotrienos na fagocitose via outros receptores. Os objetivos deste trabalho são: a) ampliar o conhecimento sobre as vias de sinalização ativadas pelos leucotrienos durante a fagocitose de hemácias opsonizadas por IgG; b) avaliar o efeito

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42

Athayde, Letícia Antunes. "Participação dos leucotrienos na secreção de vasopressina durante sepse experimental." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-01042009-141522/.

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Durante a sepse ocorre aumento da produção de mediadores inflamatórios, dentro os quais leucotrienos (LTs), além de hipotensão seguida de aumento da secreção de vasopressina (AVP) na fase inicial e diminuição na fase tardia, a despeito da progressão da hipotensão. Estudos recentes revelam que neurônios vasopressinérgicos contêm alto conteúdo da enzima LTC4 sintase, e também há relatos de que estruturas neurais que se conectam a esses neurônios possuem receptores para LTs, sugerindo que os mesmos podem ter uma tarefa na secreção de AVP. Este estudo avaliou a participação dos LTs centrais e peri

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43

Martins, Thalita Freitas. "Efeito do MK-886, um inibidor da síntese de leucotrienos, na produção de óxido nítrico e na liberação de vasopressina durante sepse experimental." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-26012010-123707/.

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Evidências sugerem que os leucotrienos (LTs) e óxido nítrico (NO) podem apresentar um papel na liberação de vasopressina (AVP) que ocorre durante a fase inicial da sepse. Além disso, é conhecido que os LTs afetam a produção de NO. Nosso objetivo foi analisar o efeito do MK-886, um inibidor da síntese de LTs, na produção de NO e na liberação de AVP durante sepse experimental. Ratos Wistar receberam injeções i.p. de MK-886 (1.0, 2.0 ou 4.0mg/kg) ou veículo (DMSO 5%) 1h antes da ligadura e perfuração cecal (CLP) ou operação fictícia. Em um grupo a taxa de sobrevida foi monitorada durante 3 dias.

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44

Nunes, Gladston Alves. "Efeito de leucotrienos sobre o estado de ativação de macrófagos de camundongos estressados /." Botucatu : [s.n.], 2005. http://hdl.handle.net/11449/96638.

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Orientador: José Maurício Sforcin<br>Resumo: O estresse compreende uma multiplicidade de eventos, envolvendo o sistema imune e ativação do sistema nervoso autônomo, bem como a ativação do eixo hipotálamo-pituitária-adrenal, com conseqüente aumento de catecolaminas e glicocorticóides, respectivamente. Além do papel imunomodulador dos leucotrienos na síntese de citocinas, este mediador contribui para a produção de óxido nítrico (NO), o qual é importante no controle da replicação de fungos, bactérias e vírus. Estudos sobre a participação de leucotrienos e intermediários reativos do oxigênio contr

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45

Balderramas, Helanderson de Almeida. "Efeito de um inibidor de leucotrienos no processo inflamatório decorrente da infecção por Paracoccidioides brasiliensis em camundongos geneticamnte selecionados /." Botucatu : [s.n.], 2009. http://hdl.handle.net/11449/89969.

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Orientador: Silvio Luis de Oliveira<br>Banca: José Maurício Sforcin<br>Banca: Orlando Garcia Ribeiro Filho<br>Resumo: Leucotrienos são mediadores clássicos da resposta inflamatória, descritos como agentes quimiotáticos e reguladores da atividade microbicida de células do sistema imune inato, tendo papel protetor contra diferentes agentes infecciosos. Neste estudo, nós investigamos o envolvimento de leucotrienos no curso da paracoccidioidomicose murina a partir dos seguintes parâmetros imunológicos: influxo celular, atividade da mieloperoxidase, produção de NO, produção de citocinas e recuperaç

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46

Приступа, Людмила Никодимівна, Людмила Никодимовна Приступа, Liudmyla Nykodymivna Prystupa та ін. "Залежність рівнів лейкотрієнів від індексу маси тіла у хворих на бронхіальну астму". Thesis, Видавництво СумДУ, 2010. http://essuir.sumdu.edu.ua/handle/123456789/4869.

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47

Larsson, Anna-Karin. "Nitric oxide and eicosanoids : significance and interactions during antigen-induced responses in peripheral lung tissue /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-155-5/.

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Custódio, Ricardo Wesley Alberca. "A via dos leucotrienos contribui para os efeitos antiinflamatórios do treinamento físico aeróbio na asma?" Universidade Nove de Julho, 2015. http://bibliotecadigital.uninove.br/handle/tede/1347.

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Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-25T17:51:42Z No. of bitstreams: 1 Ricardo Wesley Alberca Custodio.pdf: 1719201 bytes, checksum: dde8d630cb7ae3e178cab55eaac0dd13 (MD5)<br>Made available in DSpace on 2016-05-25T17:51:42Z (GMT). No. of bitstreams: 1 Ricardo Wesley Alberca Custodio.pdf: 1719201 bytes, checksum: dde8d630cb7ae3e178cab55eaac0dd13 (MD5) Previous issue date: 2015-01-21<br>Leukotrienes (LTs) play a central role in the pathophysiology of asthma. Aerobic exercise has been shown to be capable of reducing asthmatic inflammation. Therefore, this study investi

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Gulliksson, Magdalena. "Mast cell activation in response to osmotic and immunological stimulation with focus on release of eicosanoid mediators /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-091-6/.

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Oliveira, Flávia Amadeu de. "Mecanismos intracelulares induzidos por leucotrienos durante a diferenciação osteogênica." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-24052018-182709/.

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Os leucotrienos (LTs) são mediadores inflamatórios derivados da via 5- lipoxigenase (5-LO), com contribuição relevante na reabsorção óssea. Neste estudo investigamos o papel dos LTs na diferenciação osteogênica e o seu impacto na osteoclatogênese. Assim, foi avaliado o perfil ósseo dos camundongos 129/Sv (WT) e 5-LO Knockout (5-LO KO) por meio de microtomografia computadorizada, evidenciando maior densidade óssea vertebral e trabéculas mais espessas em machos 5-LO KO. Após isso, osteoblastos primários (OBL) foram isolados e cultivados para determinar a atividade de fosfatase alcalina (ALP) e o

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