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Journal articles on the topic 'LHCSR1'

Author: Grafiati

Published: 11 March 2023

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1

Girolomoni, Laura, Stefano Cazzaniga, Alberta Pinnola, Federico Perozeni, Matteo Ballottari, and Roberto Bassi. "LHCSR3 is a nonphotochemical quencher of both photosystems inChlamydomonas reinhardtii." Proceedings of the National Academy of Sciences 116, no. 10 (2019): 4212–17. http://dx.doi.org/10.1073/pnas.1809812116.

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Photosynthetic organisms prevent oxidative stress from light energy absorbed in excess through several photoprotective mechanisms. A major component is thermal dissipation of chlorophyll singlet excited states and is called nonphotochemical quenching (NPQ). NPQ is catalyzed in green algae by protein subunits called LHCSRs (Light Harvesting Complex Stress Related), homologous to the Light Harvesting Complexes (LHC), constituting the antenna system of both photosystem I (PSI) and PSII. We investigated the role of LHCSR1 and LHCSR3 in NPQ activation to verify whether these proteins are involved i

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2

Kosuge, Kotaro, Ryutaro Tokutsu, Eunchul Kim, et al. "LHCSR1-dependent fluorescence quenching is mediated by excitation energy transfer from LHCII to photosystem I in Chlamydomonas reinhardtii." Proceedings of the National Academy of Sciences 115, no. 14 (2018): 3722–27. http://dx.doi.org/10.1073/pnas.1720574115.

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Photosynthetic organisms are frequently exposed to light intensities that surpass the photosynthetic electron transport capacity. Under these conditions, the excess absorbed energy can be transferred from excited chlorophyll in the triplet state (3Chl*) to molecular O2, which leads to the production of harmful reactive oxygen species. To avoid this photooxidative stress, photosynthetic organisms must respond to excess light. In the green alga Chlamydomonas reinhardtii, the fastest response to high light is nonphotochemical quenching, a process that allows safe dissipation of the excess energy

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Roach, Thomas. "LHCSR3-Type NPQ Prevents Photoinhibition and Slowed Growth under Fluctuating Light in Chlamydomonas reinhardtii." Plants 9, no. 11 (2020): 1604. http://dx.doi.org/10.3390/plants9111604.

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Natural light intensities can rise several orders of magnitude over subsecond time spans, posing a major challenge for photosynthesis. Fluctuating light tolerance in the green alga Chlamydomonas reinhardtii requires alternative electron pathways, but the role of nonphotochemical quenching (NPQ) is not known. Here, fluctuating light (10 min actinic light followed by 10 min darkness) led to significant increase in NPQ/qE-related proteins, LHCSR1 and LHCSR3, relative to constant light of the same subsaturating or saturating intensity. Elevated levels of LHCSR1/3 increased the ability of cells to

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4

Dinc, Emine, Lijin Tian, Laura M. Roy, Robyn Roth, Ursula Goodenough, and Roberta Croce. "LHCSR1 induces a fast and reversible pH-dependent fluorescence quenching in LHCII in Chlamydomonas reinhardtii cells." Proceedings of the National Academy of Sciences 113, no. 27 (2016): 7673–78. http://dx.doi.org/10.1073/pnas.1605380113.

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To avoid photodamage, photosynthetic organisms are able to thermally dissipate the energy absorbed in excess in a process known as nonphotochemical quenching (NPQ). Although NPQ has been studied extensively, the major players and the mechanism of quenching remain debated. This is a result of the difficulty in extracting molecular information from in vivo experiments and the absence of a validation system for in vitro experiments. Here, we have created a minimal cell of the green alga Chlamydomonas reinhardtii that is able to undergo NPQ. We show that LHCII, the main light harvesting complex of

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Gabilly, Stéphane T., Christopher R. Baker, Setsuko Wakao, et al. "Regulation of photoprotection gene expression in Chlamydomonas by a putative E3 ubiquitin ligase complex and a homolog of CONSTANS." Proceedings of the National Academy of Sciences 116, no. 35 (2019): 17556–62. http://dx.doi.org/10.1073/pnas.1821689116.

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Photosynthetic organisms use nonphotochemical quenching (NPQ) mechanisms to dissipate excess absorbed light energy and protect themselves from photooxidation. In the model green alga Chlamydomonas reinhardtii, the capacity for rapidly reversible NPQ (qE) is induced by high light, blue light, and UV light via increased expression of LHCSR and PSBS genes that are necessary for qE. Here, we used a forward genetics approach to identify SPA1 and CUL4, components of a putative green algal E3 ubiquitin ligase complex, as critical factors in a signaling pathway that controls light-regulated expression

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Roach, Thomas, Chae Sun Na, Wolfgang Stöggl, and Anja Krieger-Liszkay. "The non-photochemical quenching protein LHCSR3 prevents oxygen-dependent photoinhibition in Chlamydomonas reinhardtii." Journal of Experimental Botany 71, no. 9 (2020): 2650–60. http://dx.doi.org/10.1093/jxb/eraa022.

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Abstract Non-photochemical quenching (NPQ) helps dissipate surplus light energy, preventing formation of reactive oxygen species (ROS). In Chlamydomonas reinhardtii, the thylakoid membrane protein LHCSR3 is involved in pH-dependent (qE-type) NPQ, lacking in the npq4 mutant. Preventing PSII repair revealed that npq4 lost PSII activity faster than the wild type (WT) in elevated O2, while no difference between strains was observed in O2-depleted conditions. Low Fv/Fm values remained 1.5 h after moving cells out of high light, and this qH-type quenching was independent of LHCSR3 and not accompanie

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Kondo, Toru, Jesse B. Gordon, Alberta Pinnola, Luca Dall’Osto, Roberto Bassi, and Gabriela S. Schlau-Cohen. "Microsecond and millisecond dynamics in the photosynthetic protein LHCSR1 observed by single-molecule correlation spectroscopy." Proceedings of the National Academy of Sciences 116, no. 23 (2019): 11247–52. http://dx.doi.org/10.1073/pnas.1821207116.

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Biological systems are subjected to continuous environmental fluctuations, and therefore, flexibility in the structure and function of their protein building blocks is essential for survival. Protein dynamics are often local conformational changes, which allows multiple dynamical processes to occur simultaneously and rapidly in individual proteins. Experiments often average over these dynamics and their multiplicity, preventing identification of the molecular origin and impact on biological function. Green plants survive under high light by quenching excess energy, and Light-Harvesting Complex

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8

Tian, Lijin, Wojciech J. Nawrocki, Xin Liu, Iryna Polukhina, Ivo H. M. van Stokkum, and Roberta Croce. "pH dependence, kinetics and light-harvesting regulation of nonphotochemical quenching inChlamydomonas." Proceedings of the National Academy of Sciences 116, no. 17 (2019): 8320–25. http://dx.doi.org/10.1073/pnas.1817796116.

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Sunlight drives photosynthesis but can also cause photodamage. To protect themselves, photosynthetic organisms dissipate the excess absorbed energy as heat, in a process known as nonphotochemical quenching (NPQ). In green algae, diatoms, and mosses, NPQ depends on the light-harvesting complex stress-related (LHCSR) proteins. Here we investigated NPQ inChlamydomonas reinhardtiiusing an approach that maintains the cells in a stable quenched state. We show that in the presence of LHCSR3, all of the photosystem (PS) II complexes are quenched and the LHCs are the site of quenching, which occurs at

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9

Dikaios, Ioannis, Christo Schiphorst, Luca Dall’Osto, Alessandro Alboresi, Roberto Bassi, and Alberta Pinnola. "Functional analysis of LHCSR1, a protein catalyzing NPQ in mosses, by heterologous expression in Arabidopsis thaliana." Photosynthesis Research 142, no. 3 (2019): 249–64. http://dx.doi.org/10.1007/s11120-019-00656-3.

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10

Pinnola, Alberta, Hristina Staleva-Musto, Stefano Capaldi, Matteo Ballottari, Roberto Bassi, and Tomáš Polívka. "Electron transfer between carotenoid and chlorophyll contributes to quenching in the LHCSR1 protein from Physcomitrella patens." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857, no. 12 (2016): 1870–78. http://dx.doi.org/10.1016/j.bbabio.2016.09.001.

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11

Kondo, Toru, Alberta Pinnola, Wei Jia Chen, Luca Dall'Osto, Roberto Bassi, and Gabriela S. Schlau-Cohen. "Single-molecule spectroscopy of LHCSR1 protein dynamics identifies two distinct states responsible for multi-timescale photosynthetic photoprotection." Nature Chemistry 9, no. 8 (2017): 772–78. http://dx.doi.org/10.1038/nchem.2818.

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12

Correa-Galvis, Viviana, Petra Redekop, Katharine Guan, et al. "Photosystem II Subunit PsbS Is Involved in the Induction of LHCSR Protein-dependent Energy Dissipation in Chlamydomonas reinhardtii." Journal of Biological Chemistry 291, no. 33 (2016): 17478–87. http://dx.doi.org/10.1074/jbc.m116.737312.

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Non-photochemical quenching of excess excitation energy is an important photoprotective mechanism in photosynthetic organisms. In Arabidopsis thaliana, a high quenching capacity is constitutively present and depends on the PsbS protein. In the green alga Chlamydomonas reinhardtii, non-photochemical quenching becomes activated upon high light acclimation and requires the accumulation of light harvesting complex stress-related (LHCSR) proteins. Expression of the PsbS protein in C. reinhardtii has not been reported yet. Here, we show that PsbS is a light-induced protein in C. reinhardtii, whose a

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13

Strenkert, Daniela, Stefan Schmollinger, Sean D. Gallaher, et al. "Multiomics resolution of molecular events during a day in the life of Chlamydomonas." Proceedings of the National Academy of Sciences 116, no. 6 (2019): 2374–83. http://dx.doi.org/10.1073/pnas.1815238116.

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The unicellular green algaChlamydomonas reinhardtiidisplays metabolic flexibility in response to a changing environment. We analyzed expression patterns of its three genomes in cells grown under light–dark cycles. Nearly 85% of transcribed genes show differential expression, with different sets of transcripts being up-regulated over the course of the day to coordinate cellular growth before undergoing cell division. Parallel measurements of select metabolites and pigments, physiological parameters, and a subset of proteins allow us to infer metabolic events and to evaluate the impact of the tr

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14

Allorent, Guillaume, Linnka Lefebvre-Legendre, Richard Chappuis, et al. "UV-B photoreceptor-mediated protection of the photosynthetic machinery inChlamydomonas reinhardtii." Proceedings of the National Academy of Sciences 113, no. 51 (2016): 14864–69. http://dx.doi.org/10.1073/pnas.1607695114.

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Life on earth is dependent on the photosynthetic conversion of light energy into chemical energy. However, absorption of excess sunlight can damage the photosynthetic machinery and limit photosynthetic activity, thereby affecting growth and productivity. Photosynthetic light harvesting can be down-regulated by nonphotochemical quenching (NPQ). A major component of NPQ is qE (energy-dependent nonphotochemical quenching), which allows dissipation of light energy as heat. Photodamage peaks in the UV-B part of the spectrum, but whether and how UV-B induces qE are unknown. Plants are responsive to

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Pinnola, Alberta, Leonardo Ghin, Elisa Gecchele, et al. "Heterologous Expression of Moss Light-harvesting Complex Stress-related 1 (LHCSR1), the Chlorophylla-Xanthophyll Pigment-protein Complex Catalyzing Non-photochemical Quenching, inNicotianasp." Journal of Biological Chemistry 290, no. 40 (2015): 24340–54. http://dx.doi.org/10.1074/jbc.m115.668798.

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16

Pi, Xiong, Lirong Tian, Huai-En Dai, et al. "Unique organization of photosystem I–light-harvesting supercomplex revealed by cryo-EM from a red alga." Proceedings of the National Academy of Sciences 115, no. 17 (2018): 4423–28. http://dx.doi.org/10.1073/pnas.1722482115.

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Photosystem I (PSI) is one of the two photosystems present in oxygenic photosynthetic organisms and functions to harvest and convert light energy into chemical energy in photosynthesis. In eukaryotic algae and higher plants, PSI consists of a core surrounded by variable species and numbers of light-harvesting complex (LHC)I proteins, forming a PSI-LHCI supercomplex. Here, we report cryo-EM structures of PSI-LHCR from the red alga Cyanidioschyzon merolae in two forms, one with three Lhcr subunits attached to the side, similar to that of higher plants, and the other with two additional Lhcr subu

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Montgomery, G. W., M. L. Tate, H. M. Henry, J. M. Penty, and R. M. Rohan. "The follicle-stimulating hormone receptor and luteinizing hormone receptor genes are closely linked in sheep and deer." Journal of Molecular Endocrinology 15, no. 3 (1995): 259–65. http://dx.doi.org/10.1677/jme.0.0150259.

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ABSTRACT Restriction fragment length polymorphisms were identified in sheep and deer using ovine cDNA probes for the FSH receptor (FSHR) and the LH receptor (LHCGR). FSHR and LHCGR were closely linked in sheep with no recombinants and neither receptor was linked to the Booroola fecundity gene (FecB). Both receptors were also closely linked in deer at a map distance of 3·3 cM. Linkage between the receptor genes assigns FSHR to sheep chromosome 3. Sequence analysis showed that the mammalian LHCGRs and FSHRs are more similar to each other than to mammalian TSH receptor (TSHR). Taken together, the

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Brandt, Peter, Helene Gleibs, Andrea Kohne, and Wolfgang Wiessner. "Variabilität des "light-harvesting-systems" im Zellzyklus von Chlorella fusca / Variability of the Light-Harvesting-System during the Cell Cycle of Chlorella fusca." Zeitschrift für Naturforschung C 40, no. 1-2 (1985): 115–21. http://dx.doi.org/10.1515/znc-1985-1-222.

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The seven chlorophyll-protein complexes CPIa, CPI, LHCP1, LHCP2, CPa, LHCP1 and LHCP11 known in part also from the chloroplasts of higher plants were isolated from Chlorella fusca. They were characterized by their molecular weight, their absorption maxima and their ratio of chlorophyll a/chlorophyll b. The composition of the chloropyhll-protein complexes changes during the cell cycle of Chlorella fusca. The ratio of LHCP/CPI decreases at the beginning of the light period and the ratio LHCP/CPa after the 2nd hour of the light period. Both quotients increase at the 5th hour of the light period,

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Rathod, Mithun Kumar, Sreedhar Nellaepalli, Shin-Ichiro Ozawa, et al. "Assembly Apparatus of Light-Harvesting Complexes: Identification of Alb3.1–cpSRP–LHCP Complexes in the Green Alga Chlamydomonas reinhardtii." Plant and Cell Physiology 63, no. 1 (2021): 70–81. http://dx.doi.org/10.1093/pcp/pcab146.

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Abstract The unicellular green alga, Chlamydomonas reinhardtii, contains many light-harvesting complexes (LHCs) associating chlorophylls a/b and carotenoids; the major LHCIIs (types I, II, III and IV) and minor light-harvesting complexes, CP26 and CP29, for photosystem II, as well as nine LHCIs (LHCA1–9), for photosystem I. A pale green mutant BF4 exhibited impaired accumulation of LHCs due to deficiency in the Alb3.1 gene, which encodes the insertase involved in insertion, folding and assembly of LHC proteins in the thylakoid membranes. To elucidate the molecular mechanism by which ALB3.1 ass

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Pinnola, Alberta. "The rise and fall of Light-Harvesting Complex Stress-Related proteins as photoprotection agents during evolution." Journal of Experimental Botany 70, no. 20 (2019): 5527–35. http://dx.doi.org/10.1093/jxb/erz317.

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This review on the evolution of quenching mechanisms for excess energy dissipation focuses on the role of Light-Harvesting Complex Stress-Related (LHCSR) proteins versus Photosystem II Subunit S (PSBS) protein, and the reasons for the redundancy of LHCSR in vascular plants as PSBS became established.

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21

Giovagnetti, Vasco, and Alexander V. Ruban. "The evolution of the photoprotective antenna proteins in oxygenic photosynthetic eukaryotes." Biochemical Society Transactions 46, no. 5 (2018): 1263–77. http://dx.doi.org/10.1042/bst20170304.

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Photosynthetic organisms require rapid and reversible down-regulation of light harvesting to avoid photodamage. Response to unpredictable light fluctuations is achieved by inducing energy-dependent quenching, qE, which is the major component of the process known as non-photochemical quenching (NPQ) of chlorophyll fluorescence. qE is controlled by the operation of the xanthophyll cycle and accumulation of specific types of proteins, upon thylakoid lumen acidification. The protein cofactors so far identified to modulate qE in photosynthetic eukaryotes are the photosystem II subunit S (PsbS) and

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22

Levin, Guy, and Gadi Schuster. "LHC-like Proteins: The Guardians of Photosynthesis." International Journal of Molecular Sciences 24, no. 3 (2023): 2503. http://dx.doi.org/10.3390/ijms24032503.

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The emergence of chlorophyll-containing light-harvesting complexes (LHCs) was a crucial milestone in the evolution of photosynthetic eukaryotic organisms. Light-harvesting chlorophyll-binding proteins form complexes in proximity to the reaction centres of photosystems I and II and serve as an antenna, funnelling the harvested light energy towards the reaction centres, facilitating photochemical quenching, thereby optimizing photosynthesis. It is now generally accepted that the LHC proteins evolved from LHC-like proteins, a diverse family of proteins containing up to four transmembrane helices.

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Xue, Huidan, Sonja Verena Bergner, Martin Scholz, and Michael Hippler. "Novel insights into the function of LHCSR3 in Chlamydomonas reinhardtii." Plant Signaling & Behavior 10, no. 12 (2015): e1058462. http://dx.doi.org/10.1080/15592324.2015.1058462.

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24

Lorenzen, Mette, John Erik Nielsen, Christine Hjorth Andreassen, et al. "Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis." Cancers 12, no. 6 (2020): 1358. http://dx.doi.org/10.3390/cancers12061358.

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Luteinizing hormone/choriogonadotropin receptor (LHCGR) regulates gonadal testosterone production and recent studies have suggested a growth-regulatory role in somatic cancers. Here, we established that LHCGR is expressed in a fraction of seminoma cells and germ cell neoplasia in situ (GCNIS), and the seminoma-derived cell line TCam2 released LHCGR into the medium. LH treatment induced proliferation of TCam2 cells in vitro, while hCG treatment induced a non-significant 51% increase in volume of tumors formed in a TCam2 xenograft model. A specific ELISA was used to detect a soluble LHCGR in ser

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Crovetto, Francesca, Francesc Figueras, Fatima Crispi, et al. "Forms of Circulating Luteinizing Hormone Human Chorionic Gonadotropin Receptor for the Prediction of Early and Late Preeclampsia in the First Trimester of Pregnancy." Fetal Diagnosis and Therapy 38, no. 2 (2015): 94–102. http://dx.doi.org/10.1159/000371516.

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Objective: To explore the value of circulating luteinizing human chorionic gonadotropin receptor (LHCGR) forms for the prediction of preeclampsia (PE) in the first trimester of pregnancy. Methods: Case-control study, based on a cohort of 5,759 pregnancies, including 20 early PE, 20 late PE, and 300 controls. We recorded/measured maternal characteristics, mean arterial pressure (MAP), uterine artery (UtA) Doppler, placental growth factor (PlGF), soluble Fms-like tyrosine kinase-1 (sFtl-1), and LHCGR forms (hCG-LHCGR and soluble LHCGR), and their independent predictive values were analyzed by lo

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Doroszko, Milena, Marcin Chrusciel, Joanna Stelmaszewska, et al. "Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice." Cellular Physiology and Biochemistry 43, no. 3 (2017): 1064–76. http://dx.doi.org/10.1159/000481718.

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Background/Aims: Physiological role of luteinizing hormone (LH) and its receptor (LHCGR) in adrenal remains unknown. In inhibin-α/Simian Virus 40 T antigen (SV40Tag) (inhα/Tag) mice, gonadectomy-induced (OVX) elevated LH triggers the growth of transcription factor GATA4 (GATA4)-positive adrenocortical tumors in a hyperplasia-adenoma-adenocarcinoma sequence. Methods: We investigated the role of LHCGR in tumor induction, by crossbreeding inhα/Tag with Lhcgr knockout (LuRKO) mice. By knocking out Lhcgr and Gata4 in Cα1 adrenocortical cells (Lhcgr-ko, Gata4-ko) we tested their role in tumor progre

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Cheung, Janelle, Noor A. Lokman, Riya D. Abraham, et al. "Reduced Gonadotrophin Receptor Expression Is Associated with a More Aggressive Ovarian Cancer Phenotype." International Journal of Molecular Sciences 22, no. 1 (2020): 71. http://dx.doi.org/10.3390/ijms22010071.

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Follicle-stimulating hormone (FSH) and luteinising hormone (LH) play important roles in regulating cell growth and proliferation in the ovary. However, few studies have explored the expression of FSH and LH receptors (FSHR and LHCGR) in ovarian cancer, and their functional roles in cancer progression remain inconclusive. This study investigated the potential impact of both mRNA (FSHR, LHCGR) and protein (FSHR, LHCGR) expression on ovarian cancer progression using publicly available online databases, qRT-PCR (high grade serous ovarian cancers, HGSOC, n = 29 and benign ovarian tumors, n = 17) an

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Gridelet, Virginie, Marie Tsampalas, Sarah Berndt, et al. "Evidence for cross-talk between the LH receptor and LH during implantation in mice." Reproduction, Fertility and Development 25, no. 3 (2013): 511. http://dx.doi.org/10.1071/rd11241.

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The present study investigated the first interaction that occurs between the blastocyst and endometrium during implantation. Given the ethical objections to studying implantation in humans, a mouse model was used to study the dialogue between luteinising hormone (LH) and luteinising hormone receptor (LHCGR). Several studies performed on LHCGR-knockout mice have generated controversy regarding the importance of the dialogue between LH and LHCGR during implantation. There has been no demonstration of a bioactive LH-like signal produced by the murine blastocyst. The first aim of the present study

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Wang, Peng, Han Zhao, Tao Li, et al. "Hypomethylation of the LH/Choriogonadotropin Receptor Promoter Region Is a Potential Mechanism Underlying Susceptibility to Polycystic Ovary Syndrome." Endocrinology 155, no. 4 (2014): 1445–52. http://dx.doi.org/10.1210/en.2013-1764.

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Our previous genome-wide association study identified LH/choriogonadotropin receptor (LHCGR) as a susceptibility gene for polycystic ovary syndrome (PCOS). The objective of this study was to determine whether the genetic or epigenetic components associated with LHCGR participate in the pathogenesis of PCOS. The exons and flanking regions of LHCGR were sequenced from 192 women with PCOS, and no novel somatic mutations were identified. In addition, the methylation statuses of 6 cytosine-phosphate-guanine (CpG) sites in the promoter region of LHCGR were measured by pyrosequencing using peripheral

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Cannon, Jennifer D., Srinivas V. Seekallu, Catherine A. VandeVoort, and Charles L. Chaffin. "Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells." American Journal of Physiology-Endocrinology and Metabolism 296, no. 6 (2009): E1392—E1399. http://dx.doi.org/10.1152/ajpendo.90965.2008.

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During hormonally induced ovarian follicle growth, granulosa cell proliferation increases and returns to baseline prior to the administration of an ovulatory stimulus. Several key genes appear to follow a similar pattern, including the luteinizing hormone receptor (LHCGR), suggesting an association between cell cycle progression and gene expression. The expression of LHCGR mRNA in granulosa cells isolated from immature rats and treated in culture with FSH increased in a time-dependent manner, whereas administration of the cell cycle inhibitor mimosine completely suppressed expression. Although

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Lu, Xuefeng, Zheng Yan, Renfei Cai, et al. "Pregnancy and Live Birth In Women With Pathogenic LHCGR Variants Using Their Own Oocytes." Journal of Clinical Endocrinology & Metabolism 104, no. 12 (2019): 5877–92. http://dx.doi.org/10.1210/jc.2019-01276.

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Abstract Context The LH/chorionic gonadotropin receptor (LHCGR) is mainly expressed in gonads and plays important roles in estradiol production, ovulation, and luteal formation. Women with pathogenic LHCGR variants suffer from infertility, and successful fertility treatments for such women have never been reported. Objective The purpose of this study was to determine whether women with pathogenic LHCGR variants can achieve successful pregnancies through in vitro fertilization. Design Three women with LH resistance and infertility and their parents underwent exome sequencing. The biochemical ch

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Karpinska, Barbara, Sarah Owdah Alomrani, and Christine H. Foyer. "Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling." Philosophical Transactions of the Royal Society B: Biological Sciences 372, no. 1730 (2017): 20160392. http://dx.doi.org/10.1098/rstb.2016.0392.

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Concepts of organelle-to-nucleus signalling pathways are largely based on genetic screens involving inhibitors of chloroplast and mitochondrial functions such as norflurazon, lincomycin (LINC), antimycin A (ANT) and salicylhydroxamic acid. These inhibitors favour enhanced cellular oxidation, but their precise effects on the cellular redox state are unknown. Using the in vivo reduction–oxidation (redox) reporter, roGFP2, inhibitor-induced changes in the glutathione redox potentials of the nuclei and cytosol were measured in Arabidopsis thaliana root, epidermal and stomatal guard cells, together

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Costa, Marcia Helena Soares, Sorahia Domenice, Ana Claudia Latronico, et al. "Analysis of glucose-dependent insulinotropic peptide receptor (GIPR) and luteinizing hormone receptor (LHCGR) expression in human adrenocortical hyperplasia." Arquivos Brasileiros de Endocrinologia & Metabologia 53, no. 3 (2009): 326–31. http://dx.doi.org/10.1590/s0004-27302009000300005.

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OBJECTIVE: To analyze the aberrant expression of the GIPR and LHCGR in different forms of adrenocortical hyperplasia: ACTH-independent macronodular adrenal hyperplasia (AIMAH), primary pigmented nodular adrenocortical disease (PPNAD) and diffuse adrenal hyperplasia secondary to Cushing's disease (DAHCD). METHODS: We quantified GIPR and LHCGR expressions using real time PCR in 20 patients with adrenocortical hyperplasia (seven with AIMAH, five with PPNAD, and eight with DAHCD). Normal adrenals tissues were used as control and the relative expression was compared with β-actin. RESULTS: GIPR and

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Tokutsu, R., and J. Minagawa. "Energy-dissipative supercomplex of photosystem II associated with LHCSR3 in Chlamydomonas reinhardtii." Proceedings of the National Academy of Sciences 110, no. 24 (2013): 10016–21. http://dx.doi.org/10.1073/pnas.1222606110.

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de la Cruz Valbuena, Gabriel, Franco V. A. Camargo, Rocio Borrego-Varillas, et al. "Molecular Mechanisms of Nonphotochemical Quenching in the LHCSR3 Protein of Chlamydomonas reinhardtii." Journal of Physical Chemistry Letters 10, no. 10 (2019): 2500–2505. http://dx.doi.org/10.1021/acs.jpclett.9b01184.

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Nwonuma, Charles O., Tabitha A. Adelani-Akande, Omorefosa O. Osemwegie, Abiola F. Olaniran, and Toluwani A. Adeyemo. "Comparative study of in vitro antimicrobial potential and phytochemicals of some medical plants." F1000Research 8 (May 30, 2019): 81. http://dx.doi.org/10.12688/f1000research.17094.2.

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Background: Plants in traditional healthcare services in West Africa were selected based on ethnobotanical data for this study. Aqueous and ethanol extracts from these plants’ parts were comparatively screened for phytochemicals and in vitro antimicrobial activity. Methods: The antimicrobial activity of five medicinal plants’ extracts (aqueous and ethanol) were evaluated against Proteus mirabilis (LHC201), Pseudomonas aeruginosa (LHC181) and Aspergillus fumigates (LUML56) using the agar-well diffusion protocol. Retailed chloramphenicol and griseofulvin were used as positive controls respective

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Nwonuma, Charles O., Tabitha A. Adelani-Akande, Omorefosa O. Osemwegie, Abiola F. Olaniran, and Toluwani A. Adeyemo. "Preliminary in vitro antimicrobial potential and phytochemicals study of some medical plants." F1000Research 8 (January 16, 2020): 81. http://dx.doi.org/10.12688/f1000research.17094.3.

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Background: Plants in traditional healthcare services in West Africa were selected based on ethnobotanical data for this study. Aqueous and ethanol extracts from these plants’ parts were comparatively screened for phytochemicals and in vitro antimicrobial activity. Methods: The antimicrobial activity of five medicinal plants’ extracts (aqueous and ethanol) were evaluated against Proteus mirabilis (LHC201), Pseudomonas aeruginosa (LHC181) and Aspergillus fumigates (LUML56) using the agar-well diffusion protocol. Retailed chloramphenicol and griseofulvin were used as positive controls respective

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Zheng, Cuihong, Thippeswamy Gulappa, Bindu Menon, and K. M. J. Menon. "Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model." Reproduction 160, no. 2 (2020): 239–45. http://dx.doi.org/10.1530/rep-20-0058.

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Ovarian hyperstimulation syndrome (OHSS) is a common complication of ovarian stimulation associated with the administration of human chorionic gonadotropin (hCG) during assisted reproduction. We have determined the expression of luteinizing hormone receptor (Lhcgr) mRNA, vascular endothelial growth factor (VEGF), and its transcription factor, HIF1α, during the periovulatory period in a rodent model of OHSS and compared these results with normal ovulatory periods. These results showed that the downregulation of Lhcgr mRNA in response to conditions that mimic preovulatory LH surge was significan

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Juel Mortensen, Li, Mette Lorenzen, Anne Jørgensen, et al. "Possible Relevance of Soluble Luteinizing Hormone Receptor during Development and Adulthood in Boys and Men." Cancers 13, no. 6 (2021): 1329. http://dx.doi.org/10.3390/cancers13061329.

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Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are agonists for the luteinizing hormone receptor (LHCGR) which regulates male reproductive function. LHCGR may be released into body fluids. We wish to determine whether soluble LHCGR is a marker for gonadal function. Cross-sectional, longitudinal, and intervention studies on 195 healthy boys and men and 396 men with infertility, anorchia, or Klinefelter Syndrome (KS) were used to correlate LHCGR measured in serum, seminal fluid, urine, and hepatic/renal artery and vein with gonadal function. LHCGR was determined in fluids from i

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Lazzaretti, Clara, Valentina Secco, Elia Paradiso, et al. "Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling." International Journal of Molecular Sciences 22, no. 1 (2020): 151. http://dx.doi.org/10.3390/ijms22010151.

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(1) The human luteinizing hormone (LH)/chorionic gonadotropin (hCG) receptor (LHCGR) discriminates its two hormone ligands and differs from the murine receptor (Lhr) in amino acid residues potentially involved in qualitative discerning of LH and hCG. The latter gonadotropin is absent in rodents. The aim of the study is to identify LHCGR residues involved in hCG/LH discrimination. (2) Eight LHCGR cDNAs were developed, carrying “murinizing” mutations on aminoacidic residues assumed to interact specifically with LH, hCG, or both. HEK293 cells expressing a mutant or the wild type receptor were tre

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Weng, Jinyang, Asad Rehman, Pengli Li, Liying Chang, Yidong Zhang, and Qingliang Niu. "Physiological and Transcriptomic Analysis Reveals the Responses and Difference to High Temperature and Humidity Stress in Two Melon Genotypes." International Journal of Molecular Sciences 23, no. 2 (2022): 734. http://dx.doi.org/10.3390/ijms23020734.

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Due to the frequent occurrence of continuous high temperatures and heavy rain in summer, extremely high-temperature and high-humidity environments occur, which seriously harms crop growth. High temperature and humidity (HTH) stress have become the main environmental factors of combined stress in summer. The responses of morphological indexes, physiological and biochemical indexes, gas exchange parameters, and chlorophyll fluorescence parameters were measured and combined with chloroplast ultrastructure and transcriptome sequencing to analyze the reasons for the difference in tolerance to HTH s

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Jackowski, Grzegorz, and Stefan Jansson. "Characterization of Photosystem II Antenna Complexes Separated by Non-Denaturing Isoelectric Focusing." Zeitschrift für Naturforschung C 53, no. 9-10 (1998): 841–48. http://dx.doi.org/10.1515/znc-1998-9-1010.

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CP26, CP29 and three different LHC II subcomplexes have been purified from a carnation photosystem II (PSII) preparation using non-denaturing isoelectric focusing in a vertical polyacrylamide slab gel. The identity of the fractions was established by absorption spectroscopy, SDS-PAGE and immunoblotting. CP26 comprised a single apoprotein of 26.6 kDa and CP29 contained two apoproteins of 28.8 and 28.5 kDa. LHC II subcomplex A consisted of Lhcb1 homotrimers, and subcomplexes B and C consisted of Lhcb1/Lhcb2 and Lhcb1/Lhcb3 heterotrimers, respectively. We discuss the data in relation to the organ

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Lubis, Hilma Putri, Muhammad Fidel Ganis Siregar, Ichwanul Adenin, Binarwan Halim, Henry Salim Siregar, and M. Oky Prabudi. "Association between Luteinizing Hormone/Choriogonadotropin Receptor Ins18LQ Gene Polymorphism and Polycystic Ovary Syndrome." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 517–20. http://dx.doi.org/10.3889/oamjms.2020.4182.

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BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of women in the childbearing period. However, its pathophysiology is still unclear. Certain polymorphisms of the luteinizing hormone/choriogonadotropin receptor (LHCGR) genes may lead to changes in the bioactivity of this hormone. The important functional role of LHCGR in the metabolism of androgen and ovulation, the LHCGR gene variant, may be related to the risk of PCOS. AIM: The aim of this study was to evaluate the association between LHCGR Ins18LQ gene polymorphism and PCOS. METHODS: A ca

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Zhang, Xuan, Yinghui Wei, Xiaoxuan Li, et al. "The Corticosterone–Glucocorticoid Receptor–AP1/CREB Axis Inhibits the Luteinizing Hormone Receptor Expression in Mouse Granulosa Cells." International Journal of Molecular Sciences 23, no. 20 (2022): 12454. http://dx.doi.org/10.3390/ijms232012454.

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Under stress conditions, luteinizing hormone (LH)-mediated ovulation is inhibited, resulting in insufficient oocyte production and excretion during follicular development. When the body is stressed, a large amount of corticosterone (CORT) is generated, which will lead to a disorder of the body’s endocrine system and damage to the body. Our previous work showed that CORT can block follicular development in mice. Since LH acts through binding with the luteinizing hormone receptor (Lhcgr), the present study aimed to investigate whether and how corticosterone (CORT) influences Lhcgr expression in

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Lizneva, Daria, Kseniia Ievleva, Anisa Gumerova, et al. "RF10 | PMON205 LH/CG Receptor Activation Protects Mice from Diet-Induced Obesity and Modifies Adipose Tissue Immune Response." Journal of the Endocrine Society 6, Supplement_1 (2022): A27—A28. http://dx.doi.org/10.1210/jendso/bvac150.058.

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Abstract Menopause is associated with the loss of LH ovulatory surges and enhanced visceral adiposity. Visceral fat depots increase from 5-8% at premenopause to 15-20% of total body fat at postmenopause. Here, we report that high-dose LH, hCG, or small molecule LH/CGR agonist ORG43553 injected twice-a-week into 14-weeks-old C57BL/6 male mice protects them from diet-induced obesity. Testosterone levels were elevated in mice treated with LH or hCG, but not with ORG43553. Notably, the anti-obesity action of LH/hCG is independent of testosterone, as blocking the androgen receptor using flutamide y

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Costa, Marcia Helena Soares, Ana Claudia Latronico, Regina Matsunaga Martin, et al. "Expression profiles of the glucose-dependent insulinotropic peptide receptor and LHCGR in sporadic adrenocortical tumors." Journal of Endocrinology 200, no. 2 (2008): 167–75. http://dx.doi.org/10.1677/joe-08-0395.

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Glucose-dependent insulinotropic peptide receptor (GIPR) and LHCGR are G-protein-coupled receptors with a wide tissue expression pattern. Aberrant expression of these receptors has rarely been demonstrated in adult sporadic adrenocortical tumors with a lack of data on pediatric tumors. We quantified the GIPR and LHCGR expression in a large cohort of 55 patients (25 children and 30 adults) with functioning and non-functioning sporadic adrenocortical tumors. Thirty-eight tumors were classified as adenomas whereas 17 were carcinomas. GIPR and LHCGR expression were analyzed by real-time PCR and no

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Scholz, Martin, Philipp Gäbelein, Huidan Xue, Laura Mosebach, Sonja Verena Bergner, and Michael Hippler. "Light‐dependent N‐terminal phosphorylation of LHCSR3 and LHCB4 are interlinked in Chlamydomonas reinhardtii." Plant Journal 99, no. 5 (2019): 877–94. http://dx.doi.org/10.1111/tpj.14368.

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Xu, Yufei, Yulin Chen, Niu Li, et al. "Novel compound heterozygous variants in the LHCGR gene identified in a subject with Leydig cell hypoplasia type 1." Journal of Pediatric Endocrinology and Metabolism 31, no. 2 (2018): 239–45. http://dx.doi.org/10.1515/jpem-2016-0445.

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Abstract Background: Leydig cell hypoplasia (LCH) is a rare disease and one of the causes of male disorder of sexual differentiation (DSD). Inactivating mutations in the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) gene account for the underlying LCH pathogenicity. This study aimed to analyze the clinical presentation and diagnosis as well as highlight the molecular characteristics of a subject with LCH type 1. Case presentation: Clinical data were collected from the subject and analyzed. Next generation sequencing of the immediate family pedigree using peripheral blood genomic

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Cheemakurthi, Ravi Krishna, Gottumukkala Achyuta Rama Raju, Thota Sivanaryana, Kalagara Madan, Kota Murali Krishna, and Godi Sudhakar. "Case Report: A 54 base pair inactivating mutation of LHCGR in a 28-year old woman with poor ovarian response." F1000Research 4 (March 18, 2015): 72. http://dx.doi.org/10.12688/f1000research.6137.1.

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The luteinizing hormone/choriogonadotropin (LH/CG) receptor plays an important role in male and female infertility. Many studies have demonstrated that mutations at specific sites in LHCGR gene may result in mild or complete loss of receptor function. Insertions in exon-1 of LHCGR gene were first studied in male Leydig cell hypoplasia and later extended to female reproductive disorders. Previous studies have shown that these insertions play an important role in intrauterine insemination (IUI) and in vitro fertilization (IVF) outcome. Here we report a 54bp insertion in a 28-year old woman with

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Potorac, Iulia, Ashutosh Trehan, Kamila Szymańska, et al. "Compound heterozygous mutations in the luteinizing hormone receptor signal peptide causing 46,XY disorder of sex development." European Journal of Endocrinology 181, no. 2 (2019): K11—K20. http://dx.doi.org/10.1530/eje-19-0170.

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Testosterone production by the fetal testis depends on a functional relationship between hCG and the LH/chorionic gonadotropin receptor (LHCGR). Failure of the receptor to correctly respond to its ligand leads to impaired sexual differentiation in males. A phenotypically female patient with pubertal delay had a 46,XY karyotype and was diagnosed with 46,XY disorder of sex development (DSD). Novel compound heterozygous LHCGR mutations were found in the signal peptide: a duplication p.L10_Q17dup of maternal origin, and a deletion (p.K12_L15del) and a p.L16Q missense mutation of paternal origin. c

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