Journal articles on the topic 'Li shi ren wu'

Purpose – In the face of diverse national and international threats, the purpose of this paper is to explore the transformational leadership challenges in emergency services systems in Canada. These adaptive complex systems respond to critical mass emergencies, disasters and catastrophes. Design/methodology/approach – This qualitative research study uses grounded theory to examine the phenomenology of emergency services leadership from systems perspective. Using the theoretical Wu-Shi-Ren (WSR)-Li systems paradigm, this key informant study of 103 emergency leaders from 81 organizations focusses on the systemic challenges that transformational leaders face in emergency services systems. The response rate was 83.5 percent using a semi-structured and open-ended questionnaire. Findings – This key informant study underscores the competencies for transformational leadership and identifies 12 key leadership challenges in the context of the future evolution of emergency services systems. From the use of a grounded theory methodology, the new theory of transcendental transformational emergency leadership is posited. Research limitations/implications – Qualitative studies such as this key informant study underscores the relevance of the WSR-Li systems paradigm and grounded theory approach in discerning leadership challenges that are specific if not unique to emergency services systems. Practical implications – This study underscores the theoretical and pragmatic implications of the transformational leadership challenges for leadership paradigms, innovation and inter-sectorial collaborative networks and possible future emergency services research. Social implications – This study stresses the importance of addressing leadership challenges of emergency services systems as instrumental in ultimately saving lives, minimizing injuries and assuring complete health and social recovery from the scourges of emergency events nationally and internationally. Originality/value – Qualitative studies of the perspectives of strategic emergency leadership of systemic emergency services systems has not hitherto been done in Canada nor internationally. This key informant study underscores the relevance of the WSR-Li systems paradigm and grounded theory approach in discerning transformational leadership challenges that are specific if not unique to emergency services systems. Moreover, from the use of a grounded theory approach, a new theory of transcendental transformational emergency leadership emerged.

Recently, our group has reported a novel Li-ion battery cathode, ‘LT-LiMn0.5Ni0.5O2’, where LT refers to its relatively low synthesis temperature (400 °C). By collecting high energy X-ray diffraction and high-angle, annular-dark-field (HAADF) scanning-transmission electron microscopy (STEM) data, we confirm that the LT-LiMn0.5Ni0.5O2 features a unique partially disordered rock salt structure with predominant lithiated-spinel-like character. The electrochemical data indicates that the Li/LT-LiMn0.5Ni0.5O2 cells shows good cycle stability when operate between 2.5-5.0V. The 1st cycle specific discharge capacity was determined to be 225mAh/g. Two distinct voltage plateaus can be identified at approximately at ~4.6 V and ~3.5 V during discharge. The ~1 voltage separation of the plateaus is caused by the octahedral and tetrahedral site energy difference during lithium extraction and insertion.1 The discovery of LT-LiMn0.5Ni0.5O2 not only expand the compositional space for the known lithated-spinel family but also provide a practical way to increase the operational capacity of traditional spinels such like LiMn2O4 and LiMn1.5Ni0.5O2.2-5 It is well known that when synthesized at 900°C, LiMn0.5Ni0.5O2 features a layered structure.6 The existence of lithated-spinel like LiMn0.5Ni0.5O2 at low temperature (400°C) immediately raise another question: How does the synthesis temperature affect the structure and electrochemical performance of LiMn0.5Ni0.5O2? We synthesized a series of different temperature of LiMn0.5Ni0.5O2 powders. By collecting high energy X-ray diffraction and high-resolution transmission electron microscopy (HR-TEM) data, we confirm that, the LiMn0.5Ni0.5O2 exhibits a lithated spinel → disordered layered → ordered layered structure transformation as temperature increase from 400-900 °C. The Rietveld refinements results also reveals a gradual decrease of the Li/Ni exchange ratio accompanied by the synthesis temperature changes. The evolution of specific discharge capacity for different temperature LiMn0.5Ni0.5O2 shows a parabola-like curve behavior with the lowest discharge capacity at 700 °C. This unique behavior is likely to be related to the diffusion channels reconstruction along with the structure changes. 3D diffusion channels are incorporated with 2D diffusion channels at low temperature (400°C) for lithated-spinel LiMn0.5Ni0.5O2. Within the middle temperature range (500°C-700°C), the 3D channels destroy rapidly while 2D diffusion channels are not well established due to the highly disorder ratio resulting in a decrease of capacity. At higher temperature (800-900°C), the 2D diffusion channels are more well established enabling an increase of the capacity. Shi, B.; Gim, J.; Li, L.; Wang, C.; Vu, A.; Croy, J. R.; Thackeray, M. M.; Lee, E., LT-LiMn 0.5 Ni 0.5 O 2: a unique co-free cathode for high energy Li-ion cells. Chemical Communications 2021, 57 (84), 11009-11012. Thackeray, M. M.; Lee, E.; Shi, B.; Croy, J. R., Review–From LiMn2O4 to Partially-Disordered Li2MnNiO4: The Evolution of Lithiated-Spinel Cathodes for Li-Ion Batteries. Journal of The Electrochemical Society 2022, 169 (2), 020535. Gummow, R.; Thackeray, M.; David, W.; Hull, S., Structure and electrochemistry of lithium cobalt oxide synthesised at 400 C. Materials research bulletin 1992, 27 (3), 327-337. Lee, E.; Blauwkamp, J.; Castro, F. C.; Wu, J.; Dravid, V. P.; Yan, P.; Wang, C.; Kim, S.; Wolverton, C.; Benedek, R., Exploring lithium-cobalt-nickel oxide spinel electrodes for≥ 3.5 V Li-ion cells. ACS applied materials & interfaces 2016, 8 (41), 27720-27729. Lee, E.; Kwon, B. J.; Dogan, F.; Ren, Y.; Croy, J. R.; Thackeray, M. M., Lithiated Spinel LiCo1–x Al x O2 as a Stable Zero-Strain Cathode. ACS Applied Energy Materials 2019, 2 (9), 6170-6175. Yang, X.-Q.; McBreen, J.; Yoon, W.-S.; Grey, C. P., Crystal structure changes of LiMn0. 5Ni0. 5O2 cathode materials during charge and discharge studied by synchrotron based in situ XRD. Electrochemistry communications 2002, 4 (8), 649-654

Derivatives of graphene have become important materials due to their excellent properties. Graphene oxide and reduced graphene oxide are especially interesting because they are produced relatively easily, cheaply and quickly. Among many possible applications, reduced graphene oxide is a good candidate for sensor applications. Its properties can be controlled at the production stage. The precursor used and the method of oxidation have a significant influence on its properties. Therefore, it is worth take a closer look at them. In this paper we analyse the influence of the oxidation method on the size of the reduced graphene stock which determine the sensitivity of the rGO layer. We used AFM microscopy for this purpose. Full Text: PDF ReferencesS.M. Majhi, A. Mirzaei, H.W. Kim, S.S. Kim, "Reduced Graphene Oxide (rGO)-Loaded Metal-Oxide Nanofiber Gas Sensors: An Overview", Sensors 21, 4 (2021). CrossRef M. Pumera, "Graphene-based nanomaterials for energy storage", Energy Environ. Sci. 4 3 (2011). CrossRef X. Yu, H. Cheng, M. Zhang, Y. Zhao, L. Qu, G. Shi, "Graphene-based smart materials", Nat. Rev. Mater. 2, 9 (2017). CrossRef M.Y. Xia, Y. Xie, C.H. Yu, G.Y. Chen, Y.H. Li, T., Zhang, Q. Peng, "Graphene-based nanomaterials: the promising active agents for antibiotics-independent antibacterial applications", J. Control. Release 10 (2019). CrossRef X. Zhu, Y. Zhou, Y. Guo, H. Ren, C. Gao, "Nitrogen dioxide sensing based on multiple-morphology cuprous oxide mixed structures anchored on reduced graphene oxide nanosheets at room temperature", Nanotechnology 30 45 (2019). CrossRef Z. Wu, Y. Wang, S. Ying, M. Huang, C. Peng, "Fabrication of rGO/Cuprous Oxide Nanocomposites for Gas Sensing", IOP Conf. Ser.: Earth Environ. Sci. 706, 1 (2021). CrossRef S. Pei, H.M. Cheng, "The reduction of graphene oxide", Carbon 50, 9 (2012). CrossRef K. Spilarewicz-Stanek, A. Kisielewska, J. Ginter, K. Bałuszyńska, I. Piwoński, "Elucidation of the function of oxygen moieties on graphene oxide and reduced graphene oxide in the nucleation and growth of silver nanoparticles", RSC Adv. 6, 65 (2016). CrossRef R. Muzyka, S. Drewniak, T. Pustelny, M. Sajdak, Ł. Drewniak, "Characterization of Graphite Oxide and Reduced Graphene Oxide Obtained from Different Graphite Precursors and Oxidized by Different Methods Using Raman Spectroscopy Statistical Analysis", Materials 14, 4 (2021) CrossRef B. Lesiak, G. Trykowski, J. Tóth, et al. "Chemical and structural properties of reduced graphene oxide—dependence on the reducing agent", J Mater. Sci. 56 (2021). CrossRef .

The most important cathodic process in alkali metal-air (M-O2) batteries is the electrocatalytic oxygen reduction reaction (ORR) typically forming superoxide (MO2), and peroxide (M2O2).1 Cation size in aqueous solvents have been demonstrated to affect the ORR activity due to the cation hydration energy.2 However, within aprotic electrolytes, the reaction mechanisms and the activity of ORR with respect to cation size remains undetermined. Traditionally, electrochemistry has been involved in the analysis of the reaction mechanisms of ORR. Nonetheless, this technique by itself is not suitable to identify intermediaries and products of the redox reactions taking place at the electrochemical interface. The combination of cyclic voltammetry with in situ Raman spectroscopy provide the opportunity to study and develop a fundamental understanding of the ORR under potential control, accessing reaction pathways and relating them directly to surface structure.3 In this sense, the breakthrough of Shell-Isolated Nanoparticles for Enhanced Raman Spectroscopy (SHINERS)4,5 is noteworthy. SHINERS is a non-destructive, powerful technique for surface analysis that has been demonstrated to provide SERS effect even in the absence of intrinsic roughness and without requiring Au, Ag or Cu to be used as working electrodes.3,5 In this work, electrochemical measurements and SHINERS are utilised to study the effect of cation upon electrified interfaces during ORR. Zhang, J., Zhang, X.-G., Dong, J.-C., Radjenovic, P. M., Young, D. J., Yao, J.-L., Yuan, Y.-X., Tian, Z.-Q. & Li, J.-F. Real-Time Monitoring of Surface Effects on the Oxygen Reduction Reaction Mechanism for Aprotic Na–O2 Batteries. J. Am. Chem. Soc. 143, 20049–20054 (2021). Kumeda, T., Tajiri, H., Sakata, O., Hoshi, N. & Nakamura, M. Effect of hydrophobic cations on the oxygen reduction reaction on single‒crystal platinum electrodes. Nat. Commun. 9, 1–7 (2018). Guan, S., Attard, G. A. & Wain, A. J. Observation of Substituent Effects in the Electrochemical Adsorption and Hydrogenation of Alkynes on Pt{hkl} Using SHINERS. ACS Catal. 10, 10999–11010 (2020). Li, J. F., Huang, Y. F., Ding, Y., Yang, Z. L., Li, S. B., Zhou, X. S., Fan, F. R., Zhang, W., Zhou, Z. Y., Wu, D. Y., Ren, B., Wang, Z. L. & Tian, Z. Q. Shell-isolated nanoparticle-enhanced Raman spectroscopy. Nature 464, 392–395 (2010). Galloway, T. A., Dong, J.-C., Li, J.-F., Attard, G. & Hardwick, L. J. Oxygen reactions on Pt{hkl} in a non-aqueous Na+ electrolyte: site selective stabilisation of a sodium peroxy species. Chem. Sci. 10, 2956–2964 (2019).

In this letter we present a new way for constructing and developing LC-based waveguiding structures. Specifically, liquid crystalline material enriched with monomer in the proper proportions is implemented in our approach and a waveguide geometry can be created in the LC cell thanks to the photo-polymerization process allowing for LC molecules to be suspended in desired position and orientation. The latter can be enforced by external fields and UV-irradiation can be performed trough the mask of desired geometry. In this way, regions with different molecular textures (e.g. planar and homeotropic) and thus waveguiding structures can be easily created within LC layer. The main idea of this letter is not only to show a prove-of-concept of the polymer-imposed LC stabilization for such planar optical devices but to discuss differences in methodology of their practical realization. Full Text: PDF ReferencesQ. Li, Liquid crystals beyond displays: chemistry, physics, and applications (John Wiley & Sons, 2012). CrossRef J.P. Lagerwall, G. Scalia, Current App. Phys. 12, 1387 (2012). CrossRef A. Ciferri, Polymer liquid crystals (Elsevier, 2012). DirectLink D. Yang, Fundamentals of liquid crystal devices (John Wiley & Sons, 2014). CrossRef L. Vicari, Optical applications of liquid crystals (CRC press, 2016). DirectLink I. Dierking, Adv Mater 12, 167 (2000). CrossRef K. Rutkowska, M. Chychłowski, M. Kwaśny, I. Ostromęcka, J. Piłka, U. Laudyn, "Light propagation in periodic photonic structures formed by photo-orientation and photo-polymerization of nematic liquid crystals", Opto-Electr. Rev. 25, 118 (2017). CrossRef K A. Rutkowska, M. Chychłowski, U.A. Laudyn, Proc. SPIE 10325, 1032506 (2017). CrossRef B. Turowski, K.A. Rutkowska, Phot. Lett. Poland 9, 82 (2017). CrossRef H. Ren, Y. Lin, S. Wu, Opt. Commun. 261, 296 (2006). CrossRef V. Mucci and C. Vallo, J Appl Polym Sci 123, 418 (2012). CrossRef U.A. Laudyn, M. Kwaśny, K. Jaworowicz, K.A. Rutkowska, M.A. Karpierz, G. Assanto, Phot. Lett. Poland 1, 7 (2009). CrossRef M.S. Chychłowski, S. Ertman, E. Nowinowski-Kruszelnicki, T.R. Woliński, Mol. Cryst. Liquid Cryst. 553, 127 (2012). CrossRef

Eleven species of the genus Dusungwua Kemal, Kizildağ & Koçak 2020 in China are reviewed with emendation of the generic charaters. Among them, six new species, Dusungwua antennalveata Ren & Li, sp. nov., D. basinigra Ren & Li, sp. nov., D. fascecornuta Ren & Li, sp. nov., D. paripalpa Ren & Li, sp. nov., D. similiquadrangula Ren & Li, sp. nov. and D. strictivinculum Ren & Li, sp. nov. are described as new to science. Also, the following taxonomic changes are proposed: Eurhodope pseudodichromella Yamanaka, 1980 syn. nov. is synonymized with D. dichromella (Ragonot, 1893), Trachycera nipponella Yamanaka, 2000 syn. nov., Trachycera vicinella Yamanaka, 2000 syn. nov. and Trachycera yakushimensis Yamanaka, 2000 syn. nov. are synonymized with D. paradichromella (Yamanaka, 1980). The female of D. quadrangula (Du, Sung & Wu, 2005) is described for the first time. Photos of adults as well as male and female genitalia are provided, along with a key to the Chinese species and a distibution map to show the localities of these species.

The paper focused on the description of the reduced graphene oxide (rGO) structure. This material is obtained from a multistage production process. Each of these stages has a large impact on its structure (the number and type of functional groups, number of defect or the size of the flakes), and this in turn affects its properties. We would like to visualize the reduced graphene oxide, both using a diagram showing the atomic structure, as well as by imaging using scanning electron microscopy (SEM) and atomic force microscopy (AFM). In the paper, the elementary composition of selected elements and data obtained from X-ray photoelectron spectroscopy technique (XPS) will be also presented. Full Text: PDF ReferencesX. Peng, Y. Wu, N. Chen, Z. Zhu, J. Liu, and H. Wang, "Facile and highly efficient preparation of semi-transparent, patterned and large-sized reduced graphene oxide films by electrochemical reduction on indium tin oxide glass surface", Thin Solid Films 692, 137626 (2019). CrossRef L. Guo, Y.-W. Hao, P.-L. Li, J.-F. Song, R.-Z. Yang, X.-Y. Fu, S.-Y. Xie, J. Zhao and Y.-L. Zhang, "Improved NO2 Gas Sensing Properties of Graphene Oxide Reduced by Two-beam-laser Interference", Sci. Rep. 8, 1 (2018). CrossRef Y. S. Milovanov, V.A. Skryshevsky, , O.M. Slobodian, , D.O. Pustovyi, X.Tang, J.-P. Raskin, and A.N. Nazarov, "Influence of Gas Adsorption on the Impedance of Graphene Oxide", 2019 IEEE 39th Int. Conf. Electron. Nanotechnology, ELNANO 2019 - Proc. 8783946, CrossRef M. Reddeppa, B.-G. Park, , M.-D. Kim, K.R. Peta, N.D. Chinh, D. Kim, S.-G. Kim, and G. Murali, "H2, H2S gas sensing properties of rGO/GaN nanorods at room temperature: Effect of UV illumination", Sensors Actuators B. Chem. 264, (2018). CrossRef W. L. Xu, C. Ding, , M.-S. Niu, X.-Y. Yang, F. Zheng, J. Xiao, M. Zheng and X.-T. Hao, "Reduced graphene oxide assisted charge separation and serving as transport pathways in planar perovskite photodetector", Org. Electron. 81, 105663 (2020). CrossRef K. Sarkar, M. Hossain, P. Devi, K. D. M. Rao, and P. Kumar, "Self‐Powered and Broadband Photodetectors with GaN: Layered rGO Hybrid Heterojunction", Adv. Mater. Interfaces, 6, 20 (2019). CrossRef S. Pei and H. M. Cheng, "The reduction of graphene oxide", Carbon, 50, 9 (2012). CrossRef R. Muzyka, S. Drewniak, T. Pustelny, M. Chrubasik, and G. Gryglewicz, "Characterization of Graphite Oxide and Reduced Graphene Oxide Obtained from Different Graphite Precursors and Oxidized by Different Methods Using Raman Spectroscopy", Materials 11, 7 (2018). CrossRef M.-H. Tran and H. K. Jeong, "Influence of the Grain Size of Precursor Graphite on the Synthesis of Graphite Oxide", New Phys. Sae Mulli, 63, 2 (2013). CrossRef M.-H. Tran, C.-S. Yang, S. Yang, I.-J. Kim, and H. K. Jeong, "Influence of graphite size on the synthesis and reduction of graphite oxides", Curr. Appl. Phys., 14, SUPPL. 1 (2014). CrossRef N. Sharma, Y. Jain, , M. Kumari, R. Gupta, S.K. Sharma, K. Sachdev, "Synthesis and Characterization of Graphene Oxide (GO) and Reduced Graphene Oxide (rGO) for Gas Sensing Application", Macromol. Symp. 376, 1 (2017). CrossRef M. Wei, L. Qiao, , H. Zhang, S. Karakalos, K. Ma, Z. Fu, M.T. Swihart, G. Wu, "Engineering reduced graphene oxides with enhanced electrochemical properties through multiple-step reductions", Electrochim. Acta, 258 (2017). CrossRef S. Drewniak, M. Procek, R. Muzyka, T. Pustelny, "Comparison of Gas Sensing Properties of Reduced Graphene Oxide Obtained by Two Different Methods", Sensors, 20, 11 (2020). CrossRef L. Li, R.-D. Lv, S. -C. Liu, Z. D. Chen, J. Wang, Y.-G. Wang, W. Ren, "Using Reduced Graphene Oxide to Generate Q-Switched Pulses in Er-Doped Fiber Laser", Chinese Physics Letters, 35, 11 (2018) CrossRef

The Chrysacris Zheng, 1983 is a median genus in Acrididae, which contains 18 species [Tu & Cheng, 1964; Zheng, 1983; Lian & Zheng, 1987; Li & Chen, 1988; Zheng, 1988; Liu, 1990; Ren et al, 1991; Liang & Jia, 1992; Zheng et al, 1992; Ren et al, 1993; Zhang & Zheng, 1993; Zheng, 1993; Zheng & Shi, 1993; Niu, 1994; Ren et al, 1994; Zheng et al, 1995; Yin et al, 1996; Ren 2001; Ren et al, 2002; Yin et al, 2003; Zheng et al, 2011; Dong et al, 2015; Eades, et al, 2017; Zhang et al, 2017], mainly distributed in Heilongjiang, Jilin, Liaoning, Inner Mongolia, Shanxi, Shaanxi, Henan and Guizhou provinces of China. A new species of the genus Chrysacris is described from Inner Mongolia, China in this paper. Type specimens are deposited in the Natural Museum of Hebei University, Baoding, Hebei, China.

Reviewing his long reign in 1792, the Qianlong Emperor (r. 1736–1795) hailed his military triumphs as one of its central accomplishments. To underscore the importance he ascribed to these successes, he began to style himself ‘Old Man of the Ten Complete Victories’ (Shi Quan Lao Ren), after an essay in which he boldly declared he had surpassed, in ‘Ten Complete Military Victories’ (Shi Quan Wu Gong), the far-reaching westward expansions of the great Han (206 BCE–220 CE) and Tang (618–907) empires. Such an assertion, together with the program of commemoration discussed below, served to justify the immense expense incurred by frequent long-distance campaigning; to elevate all these wars to an unimpeachable level of splendor even though some were distinctly less glorious than others; and to align the Manchu Qing dynasty (16–191 i) with two of the greatest native dynasties of Chinese history and the Qianlong Emperor personally with some of the great figures of the past.

Climate change has stimulated great interest in developing clean and renewable energy conversion and storage solutions. Emerging technologies for solutions, like unitized regenerative fuel cells, metal-air batteries, and water electrolyzers, depend on the reliable catalyst materials suited for long-term application in alkaline environments[1]. In particular, the demanding reaction in these systems is the oxygen evolution reaction involving complex multielectron/proton transfer processes and thus sluggish kinetic.[2] At present, the state-of-the-art OER catalysts are IrO2 and RuO2. However, the high cost and scarcity of these materials severely prevent the wide-scale application of these systems.[3] Perovskite oxide (e.g., single perovskite expressed as ABO3) electrocatalysts are particularly considered next-generation OER catalysts due to their adjustable physicochemical properties and, as a consequence, their catalytic properties by substitution of ions in the A and B sites.[4] Via doping both at A and B site, double perovskite oxides structure can form (AA′B2O5+δ), which were shown to have stable structure during the OER due to proper O p-band center position relative to the Fermi level. The previous research shows that hexagonal perovskites exhibit enhanced catalytic activity rather than cubic or tetragonal perovskites, which is associated with the face-sharing octahedral unit. [5,6] In this work, we systematically investigate doping of parent La2CoMnO6 with Ba to tune the crystal structure and electronic structure. A series of the double perovskites with the chemical formula of La2-xBaxCoMnO6 (x = 0, 0.5, 1.5, 2) were fabricated via the modified Sol-Gel Pechini method. According to Goldschmidt tolerance factor, it is expected that when Ba amount increases in the A site, the crystal structure changes from cubic to hexagonal, which can contribute to electrocatalytic OER activity based above discussions. Furthermore, it is anticipated that increasing Ba content at the A site should result in higher valence state of transition metals due to stabilizing charge balance of the structure. It is widely reported that presence of higher valence state of transition metals is beneficial for OER. The crystal structure was confirmed by combining powder X-ray diffraction (XRD) patterns and selected area electron diffraction (SAED) patterns. The two-layer hexagonal structure of Ba2CoMnO6 (BCM) was further characterized by high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM). The results show doping of Ba into parent La2CoMnO6 resulted in the hexagonal phase formation and BCM achieves a current density of 10 mA cm–2 at a low overpotential of 288 mV and has the highest intrinsic activity in the series of BaxLa2-xCoMnO6 (x = 0, 0.5, 1, 1.5, 2). Furthermore, BCM exhibits outstanding stability of 12 h in a 0.1 M KOH electrolyte. The electronic structure and surface work function values of the catalysts were examined with X-ray photoelectron spectroscopy (XPS). XPS analysis revealed that valence state of Co and Mn increases through Ba amount in the structure, indicating the double perovskite oxide charge balance is maintained. In addition to valence state analysis, we performed work function analysis of the catalysts tested in this work. The result shows work function of the series of BaxLa2-xCoMnO6 (x = 0, 0.5, 1, 1.5, 2) substantially decreases with Ba content. Here, we show that the high intrinsic activity of BCM is not only related with the hexagonal structure and also may be related with exhibiting lower work function value in the series. In addition, our approach presents a new strategy, air quenching method, to synthesize a phase pure 2H-hexagonal double perovskite oxide. [1] Y. Zhou, X. Guan, H. Zhou, K. Ramadoss, S. Adam, H. Liu, S. Lee, H. Shi, M. Tsuchiya, D. Fong and S. Ramanathan, Nature, 534, 231-234 (2016). [2] X. Cui, P. Ren, D. Deng, J. Deng and X. Bao, Energy & Environmental Science, 9, 123-129 (2016). [3] X. Qiu, Y. Zhang, Y. Zhu, C. Long, L. Su, S. Liu and Z. Tang, Advanced Materials, 33, 2001731 (2020). [4] W. Yin, B. Weng, J. Ge, Q. Sun, Z. Li and Y. Yan, Energy & Environmental Science, 12, 442-462 (2019). [5] L. Tang, W. Zhang, D. Lin, Y. Ren, H. Zheng, Q. Luo, L. Wei, H. Liu, J. Chen and K. Tang, Inorganic Chemistry Frontiers, 7, 4488-4497 (2020). [6] C. Chen, G. King, R. M. Dickerson, P. A. Papin, S. Gupta, W. R. Kellogg and G. Wu, Nano Energy, 13, 423-432 (2015).

The genus Mongolotettix Rehn, 1928 is a small genus of family Adrididae. It has nine species discovered from the Far Eastern Asian countries, including China, Japan, Korea, Mongolia, and Russia [Bolívar, 1898; Uvarov, 1914; Caudell, 1921; Chogsomzhav, 1974; Li et Lian, 1994; Wan, Ren et Zhang, 1998; Xie et Li, 2000, Kim et Kim 2005; Dong, et al, 2015; Shi et al, 2016; Storozhenko, 2016; Eades et al, 2017; Zhang et al, 2017]. In the present paper, we describe a new species of the genus from Hubei, China. Type specimens are deposited in the College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.

Background:Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease that is potentially fatal. There is an unmet need to improve current therapies. In patients with SLE, we observed that serum CXCL5 levels were significantly lower than healthy control subjects and negatively correlated with disease activity(1-9).Objectives:The aim of this study is to elucidate the effect of supplemental serum CXCL5 in abrogating the pathological processes of SLE.Methods:Ten doses of exogenous CXCL5 (3µg/kg) was administered to 16-week-old Faslpr mice weekly by intravenous injection. Mice were monitored for 10 weeks. Splenic immune profile was measured by flow cytometry. Circulating cytokine and immunoglobulin profile were detected by Luminex technology. Renal function was evaluated by urinary spot albumin creatinine ratio. In situ renal immune cell infiltration and complement 3 deposition were detected by Haematoxylin and Eosin (H&E) and immunohistochemistry staining. The molecular pathways involved were examined by RNA sequencing.Results:In Faslpr mice, intravenous administration of exogenous CXCL5 significantly improved mouse survival with concomitant reduction of autoantibody secretion, proteinuria, complement 3 deposition, neutrophil infiltration and lupus nephritis classes. Through evaluating the changes of immune profile, cytokine profile and molecular pathways, we found that intravenous CXCL5 reduced inflammation via an orchestral effect of regulating neutrophil trafficking and modulating helper T cell-mediated immune response. Pharmacokinetic and real-time Polymerase Chain Reaction studies further demonstrated that this orchestration was triggered by a cascade reaction - restoring vascular under-expressed CXCL5 by an exogenous stimulation, re-establishing the normal serum levels of endogenous CXCL5 and reverting the CXCL5 chemokine gradient between inflamed tissues and blood circulation.Conclusion:Managing the dysregulation of CXCL5 by exogenous supplement may provide a new option for SLE therapy.References:[1]Dufies M, Grytsai O, Ronco C, et al. New CXCR1/CXCR2 inhibitors represent an effective treatment for kidney or head and neck cancers sensitive or refractory to reference treatments. Theranostics. 2019;9(18):5332-5346. doi:10.7150/thno.34681[2]Yildirim K, Colak E, Aktimur R, et al. Clinical Value of CXCL5 for Determining of Colorectal Cancer. Asian Pac J Cancer Prev. Sep 26 2018;19(9):2481-2484. doi:10.22034/apjcp.2018.19.9.2481[3]Wu K, Yu S, Liu Q, Bai X, Zheng X. The clinical significance of CXCL5 in non-small cell lung cancer. Onco Targets Ther. 2017;10:5561-5573. doi:10.2147/ott.s148772[4]Zhao J, Ou B, Han D, et al. Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3beta/beta-catenin pathways. Mol Cancer. Mar 29 2017;16(1):70. doi:10.1186/s12943-017-0629-4[5]Han KQ, Han H, He XQ, et al. Chemokine CXCL1 may serve as a potential molecular target for hepatocellular carcinoma. Cancer Med. Oct 2016;5(10):2861-2871. doi:10.1002/cam4.843[6]Pappa CA, Tsirakis G, Kanellou P, et al. Monitoring serum levels ELR+ CXC chemokines and the relationship between microvessel density and angiogenic growth factors in multiple myeloma. Cytokine. Dec 2011;56(3):616-20. doi:10.1016/j.cyto.2011.08.034[7]Zhang L, Li H, Ge C, et al. CXCL3 contributes to CD133(+) CSCs maintenance and forms a positive feedback regulation loop with CD133 in HCC via Erk1/2 phosphorylation. Sci Rep. Jun 3 2016;6:27426. doi:10.1038/srep27426[8]Matsubara J, Honda K, Ono M, et al. Reduced plasma level of CXC chemokine ligand 7 in patients with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. Jan 2011;20(1):160-71. doi:10.1158/1055- 9965.epi-10-0397[9]Ma Y, Ren Y, Dai ZJ, Wu CJ, Ji YH, Xu J. IL-6, IL-8 and TNF-alpha levels correlate with disease stage in breast cancer patients. Adv Clin Exp Med. May-Jun 2017;26(3):421-426. doi:10.17219/acem/62120Disclosure of Interests:None declared

The ever-increasing requirements in the high-energy density of lithium-ion batteries (LIBs) and current bottlenecks in cobalt supply place restrictions on the development of the state-of-the-art cathode materials with fine-tuned chemical composition by substituting the cobalt with nickel and manganese. In the layered structure ternary systems (LiNi1-y-zMnyCozO2, NCM), three transition-metal ions play a distinctive role that determines the physicochemical properties. A comprehensive understanding of the basic contribution of each transition metal is critical for further complete replacing expensive cobalt.[1] Here, we demonstrate cobalt and manganese behaviors by comparing various layered oxides with different chemical compositions to reveal their corresponding contributions.[2] Our results affirmed that cobalt plays an undeniable role in fast degradation, and found that cobalt is more destructive than Ni at high voltages. Even the possible instability induced by manganese (III) Jahn-Teller distortion [3], Mn(IV) substitution in the lattice can effectively alleviate this destructive and enables a high potential functionality. By further regulating the chemical composition with a concentration gradient strategy, Co-enriched surface and Mn-enriched core design in Ni-rich particles determines a robust structure, which can effectively suppress the owing to the low stiffness of the surface and stable structure in the core region. With these fundamental discoveries, we provide a guide for developing the promising Co-free cathodes to meet the increasing demand for high-energy density LIBs. References [1] M. Li, J. Lu. Science, 2020, 367, 979-980. [2] T. Liu, L. Yu, J. Liu, J. Lu, X. Bi, A. Dai, M. Li, M. Li, Z. Hu, L. Ma, D. Luo, J. Zheng, T. Wu, Y. Ren, J. Wen, F. Pan, K. Amine. Nat. Energy, 2021, 6, 277-286. [3] T. Liu, A. Dai, J. Lu, Y. Yuan, Y. Xiao, L. Yu, M. Li, J. Gim, L. Ma, J. Liu, C. Zhan, L. Li, J. Zheng, Y. Ren, T. Wu, R. S.-Yassar, J. Wen, F. Pan, K. Amine. Nat. Commun., 2019, 10, 4721. [4] T. Liu, L. Yu, J. Lu, T. Zhou, X. Huang, Z. Cai, A. Dai, J. Gim, Y. Ren, X. Xiao, M. V. Holt, Y. S. Chu, I. Arslan, J. Wen, K. Amine. Nat. Commun., 2021, 12, 6024.

TheHuainanziis a Former Han 前漢 dynasty (202 B.C.E.–9 C.E.) compendium of knowledge written at the court of Huainan and presented to Emperor Wu of the Han 漢武帝 in 139 by Liu An 劉安 (?179–122), the king of Huainan. Liu An was the grandson of the Han “progenitor” Gaozu 高祖 (Liu Bang 劉邦 r. 202–195), and he was the uncle of the reigning emperor Wu (r. 140–87). According to the author(s) of the text’s postface, “Yao lue” 要略 or “A Summary of the Essentials,” the work seeks to provide a comprehensive account or chronicle of thedao道 (conventionally translated as the “Way”), understood broadly to encompass the cosmos (tiandi天地 or “Heaven and Earth”), human beings (ren人) and their affairs (shi事), and the relationship between them. The account of thedaopresented in its chapters is not, however, purely descriptive. TheHuainanziis foremost a political treatise containing instructions worthy of a sage-king (shengwang聖王) to be employed by the ruler as the proper model or standard by which to govern the empire.

Artikel review ini memberikan informasi tentang aplikasi polianilina (PANI) dan kompositnya sebagai sensor gas berbahaya khususnya amonia (NH3). Kajian yang dibahas pada artikel ini meliputi sifat gas NH3, material komposit, kinerja sensor, serta limit deteksi. Tinjauan sensor gas amonia berbasis polimer konduktif polianilina secara menyeluruh diambil dari referensi sepuluh tahun terakhir. Sebagai contoh, komposit polianilina dengan turunan karbon seperti reduced Graphene Oxide (rGO) dan Carbon Nanotube menunjukkan limit deteksi hingga 46 ppb dengan waktu pemulihan hanya 75 detik. Selain itu, komposit PANI dengan logam seperti Ag, Sr dan sebagainya, menunjukkan limit deteksi yang lebih besar yaitu 1 ppm, namun terdapat keunggulan dimana waktu pemulihan hanya 4 deti. Oleh sebab itu, polimer konduktif polianilina menjadi material yang sangat menjanjikan untuk mendeteksi keberadaan gas NH3. Terakhir, mekanisme penginderaan gas amonia terhadap material PANI juga dibahas pada tulisan ini. 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Wang et al., “Enhanced Sensitivity and Stability of Room-Temperature NH3 Sensors Using Core–Shell CeO2 Nanoparticles@Cross-linked PANI with p–n Heterojunctions,” ACS Applied Materials &Interfaces, vol. 6, no. 16, pp. 14131–14140, Aug. 2014, doi: 10.1021/am503286h. [14] Y. Guo et al., “Hierarchical graphene–polyaniline nanocomposite films for high-performance flexible electronic gas sensors,” Nanoscale, vol. 8, no. 23, pp. 12073–12080, 2016, doi: 10.1039/C6NR02540D. [15] M. Eising, C. E. Cava, R. V. Salvatierra, A. J. G. Zarbin, and L. S. Roman, “Doping effect on self-assembled films of polyaniline and carbon nanotube applied as ammonia gas sensor,” Sensors and Actuators B: Chemical, vol. 245, pp. 25–33, 2017, doi: https://doi.org/10.1016/j.snb.2017.01.132. [16] S. Bai et al., “Transparent conducting films of hierarchically nanostructured polyaniline networks on flexible substrates for high-performance gas sensors,” Small, vol. 11, no. 3, 2015, doi: 10.1002/smll.201401865. [17] Z. Wu et al., “Enhanced sensitivity of ammonia sensor using graphene/polyaniline nanocomposite,” Sensors and Actuators, B: Chemical, vol. 178, 2013, doi: 10.1016/j.snb.2013.01.014. [18] N. R. Tanguy, B. Wiltshire, M. Arjmand, M. H. Zarifi, and N. Yan, “Highly Sensitive and Contactless Ammonia Detection Based on Nanocomposites of Phosphate-Functionalized Reduced Graphene Oxide/Polyaniline Immobilized on Microstrip Resonators,” ACS Applied Materials and Interfaces, vol. 12, no. 8, 2020, doi: 10.1021/acsami.9b21063. [19] D. Maity and R. T. R. Kumar, “Polyaniline Anchored MWCNTs on Fabric for High Performance Wearable Ammonia Sensor,” ACS Sensors, vol. 3, no. 9, 2018, doi: 10.1021/acssensors.8b00589. [20] J. Ma et al., “Multi-walled carbon nanotubes/polyaniline on the ethylenediamine modified polyethylene terephthalate fibers for a flexible room temperature ammonia gas sensor with high responses,” Sensors and Actuators, B: Chemical, vol. 334, May 2021, doi: 10.1016/j.snb.2021.129677. [21] A. 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By establishing a fuzzy mathematical evaluation model based on physical and chemical indicators, this paper investigates the genetic toxic pollution of Chaohu Lake in 2016 through the micronucleus technology of the Vicia faba root tip and evaluates the water quality of Chaohu Lake. The results show that, in recent years, the overall water quality of the lakes around Chaohu has improved slightly, but the pollution levels of some areas (such as Nan Fei He and Shi Wu Li He) are still serious. The results can also provide a more reliable theoretical basis for the planning and management of environment protection.

ABSTRACT(N.B. A version of this paper has now been published in Kaogu 1983.6:537-41.)Fu Hao (or Fu Zi ) appears in the oracle-bone inscriptions from Anyang. The name is often seen in Period I inscriptions (from the time of Wu Ding) and occasionally in Period IV inscriptions (from the time of Wu Yi and Wen Ding). The two are separated by four kings (Zu Geng, Zu Jia, Lin Xin, and Kang Ding), perhaps by as much as one hundred years. Does the Fu Hao in both periods refer to the same person? How can we explain this phenomenon?In the oracle-bone records of people and their activities there are cases where one figure is active in different periods. These names are often also place names, and these figures possess a populace and products. These names are probably what is termed “Clan-Territory titles” (a term found in the Gu shi kao, as quoted in the “Zheng yi” commentary to the Zuo zhuan). Based on their clan name they served hereditarily as officials. These clan names occur in historical literature, as in “In the past, our former kings were for generations Lords of Millet (Hou Ji ), serving under the Yü and Xia “(Guo yü “Zhou Yü” ); or “The Zhong and Li clans generation after generation ordered heaven and earth, … the Sima clan for generation after generation was in charge of the history of Zhou” (Shi ji, “Taishigong zixu” ).

Lithium metal is considered as one of the most promising anode candidates for high-energy batteries [1-3]. However, safety concerns induced by the formation of Li dendrites largely hinder the practical application of lithium-metal batteries [4]. It is anticipated that the use of non-flammable inorganic solid-state electrolytes can resolve these safety issues [5], but solid ceramic electrolytes generally suffer from poor physical contact with the electrode and poor electro-/chemical stability at the electrolyte|electrode interface [6]. Herein, we report on a thin and flexible hybrid electrolyte composed of NASICON-type Li1.3Al0.3Ti1.7(PO4)3 (LATP), a polymer binder, and a small amount of an ionic liquid-based electrolyte. To reinforce the interfacial stability between LATP and Li, we coat an ultrathin polysiloxane-based single-ion conducting polymer (PSiO) on the Li metal surface via a simple dip-coating method. The implementation of PSiO-coated Li (PSiO@Li) in symmetric PSiO@Li||PSiO@Li cells enables a substantial extension of the cycle life, yielding >2,000 h of stable lithium stripping-plating. The full-cells comprising PSiO@Li as the negative electrode, LiNi0.88Co0.09Mn0.03O2 (NCM88) as the positive electrode active material, and the aforementioned hybrid electrolyte exhibit substantially enhanced rate capability at high dis-/charge rates above 0.5C and greatly prolonged cycle life at 1C. The superior performance achieved herein is mainly attributed to: (1) the prevented direct contact between LATP and Li, thus avoiding the reduction of LATP and the formation of mixed ion-electron conducting interphases; (2) the regulated Li+ flux at the electrode|electrolyte interface, ensuring homogeneous Li+ stripping-plating; and (3) the promoted intimate contact between PSiO and Li via the formation of Si−O−Li bonds. References [1] T. Li, X.-Q. Zhang, P. Shi, Q. Zhang, Joule, 3 (2019) 2647-2661. [2] B. Horstmann, J. Shi, R. Amine, M. Werres, X. He, H. Jia, F. Hausen, I. Cekic-Laskovic, S. Wiemers-Meyer, J. Lopez, D. Galvez-Aranda, F. Baakes, D. Bresser, C.-C. Su, Y. Xu, W. Xu, P. Jakes, R.-A. Eichel, E. Figgemeier, U. Krewer, J.M. Seminario, P.B. Balbuena, C. Wang, S. Passerini, Y. Shao-Horn, M. Winter, K. Amine, R. Kostecki, A. Latz, Energy Environ. Sci., 14 (2021) 5289-5314. [3] S. Wang, P. Xiong, J. Zhang, G. Wang, Energy Storage Materials, 29 (2020) 310-331. [4] Z. Yu, Y. Cui, Z. Bao, Cell Rep. Phy. Sci., 1 (2020) 100119. [5] S. Xin, Y. You, S. Wang, H.-C. Gao, Y.-X. Yin, Y.-G. Guo, ACS Energy Lett., 2 (2017) 1385-1394. [6] A. Banerjee, X. Wang, C. Fang, E.A. Wu, Y.S. Meng, Chem. Rev., 120 (2020) 6878-6933.

Abstract This paper reports on a corpus-based study aimed at reexamining the typological status and diachronic change of motion expressions in Chinese, drawing on parallel texts consisting of autonomous motion expressions in Old Chinese (OC) and its Modern Chinese (MoC) translation. The results show that MoC significantly differs from OC both in the preference of lexicalization patterns (Talmyan typology) and semantic components distributed in discourse (Slobinian typology) when narrating similar motion scenes. However, these results fail to support the viewpoint that Chinese has undergone a change from a verb- to a satellite-frame (Li 1993; Talmy 2000; Peyraube 2006; Shi & Wu 2014). It is argued that (i) the Talmyan typology and the Slobinian typology should be treated separately. In Talmyan typology, the diachrony of Chinese demonstrates the change of a V- to a parallel-frame, in that satellite- and verb-framed constructions in MoC have equal frequency and show no bias for the encoding of subtypes of autonomous motion. In Slobinian typology, MoC remains as a Path-salient language, as it gives considerable weight to the expression of Path; (ii) the dominant lexicalization pattern in a language varies from one sub-domain of motion to another (see also Lamarre 2003), and thus the typology of motion expressions is sub-domain-specific; and (iii) motivating forces and blocking forces, furthermore, co-exist diachronically for the typological evolution of motion encoding due to the idiosyncrasy of the morphosyntactic system.

Abstract Src homology region 2 domain-containing phosphatase-2 (SHP-2) is a key node in the RAS signaling pathway. Allosteric inhibition of SHP2 phosphatase is a potential therapeutic strategy for cancers harboring oncogenic mutations in the KRAS pathway. SHP2 also participates in the signal transduction downstream of regulatory immunoreceptors, and it has been shown in preclinical models that SHP2 inhibition drives anti-tumor immunity through modulation of both innate and adaptive mechanism. BPI-442096 is a potent, selective, and orally bioavailable small molecule SHP2 inhibitor. It exhibited significant anti-proliferation activities against multiple KRAS mutant cancer cell lines, including those from NSCLC, PDAC, CRPC, etc. BPI-442096 dose-dependently inhibited SHP2 phosphatase and downstream ERK phosphorylation in cancer cells, as well as NFAT reporter gene expression downstream of PD-1/PD-L1 signaling in immune cells. In vivo, BPI-442096 demonstrated strong tumor growth inhibition in KRASG12C, KRASG12D, and KRASG12V mutant xenograft mouse models. BPI-442096 also exhibited anti-tumor immunity in the MC38 syngeneic model, as a single agent or in combination with anti-PD1/PD-L1 drugs. Moreover, BPI-442096 combining with KRASG12C inhibitor may reverse intrinsic and acquired resistance to KRASG12C inhibition. Adequate oral exposure across multiple pre-clinical species and good ADME properties ensured the druggability of BPI-442096. In conclusion, BPI-442096 exhibits a robust anti-tumor effect in multiple KRAS mutant models and enhanced anti-cancer immunity in syngeneic mouse models, and it shows multiple combination potentials to overcome drug resistance. Phase 1 clinical trial is planned in early 2022. Citation Format: Ling Li, Bang Fu, Han Han, Zhongxin Sun, Xiangdong Zhao, Xuepeng Jv, Jun Tong, Jiayu Zhao, Zhengyao Zou, Haibo Chen, Xiaoyun Liu, Wei Ren, Yinlong Li, Wenmao Wu, Jing Guo, Dan Yan, Xiangyong Liu, Hong Lan, Hao Wu, Lieming Ding, Jiabing Wang. BPI-442096: A potent and selective inhibitor of SHP2 for the treatment of multiple cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5463.

Researchers around the world are striving to develop new materials for energy-efficient and high energy density lithium-ion batteries [1]. Lithium metal with a theoretical specific capacity of 3860 mAh/g, low density (0.534 g/cm3), and the lowest potential (−3.040 V vs. standard hydrogen electrode) is consider the ultimate anode material for high specific energy batteries [2]. However, various issues remain to be address that hinder its use in commercial batteries, namely, cycling stability, Coulombic efficiency, and safety aspects associated with dendritic growth [3]. Inactive lithium, also known as “dead lithium,” originating from the dendrites that become separated from the surface over prolonged cycling contribute to anode capacity loss and require high negative to positive electrode capacity ratio (N/P). In addition, due to the extremely low standard redox potential of lithium, electrolytes readily react with the lithium metal surface even without any potential polarization. These reactions lead to the formation of mostly insoluble species in a layer often referred to as solid electrolyte interface, SEI. Ideally, the SEI layer is self-terminating; however, as fresh lithium gets exposed via dendritic growth, SEI formation continues. The steady and uncontrollable growth of SEI throughout the functional life of the battery leads to gradual resistant growth responsible for the capacity fade and eventual “death” of the battery. In previous art, alternative electrolytes, electrolyte additives, and artificial SEIs were studied [4] [5]. For example, the electrolyte additive lithium fluoride (LiF) was used in carbonate electrolytes and provided a strong protective layer that reduced side reactions and improved the life capacity of the battery [6]. Recently, 3-dimensional design of the anode’s current collector was shown to accommodate Li deposition resulting in suppressed SEI growth and volume expansion during cycling [7]. In the present work, we use sulfur-containing compounds as additives at a very low concentration (1 – 50 mM) in standard 1M LiPF6 EC:DMC (v:v = 1:1). Coin cells (2032) were assembled using lithium foil (100 mm thick), separator (Celgard), and NMC811 cathode (> 10 mg/cm2). Cells were first rested and activated at a slow rate then cycled at C/3 and 1C for charge and discharge respectively in prescribed voltage cutoff window. As shown in Figure 1, the sulfur-containing cell had more than 300 cycles before 90% capacity retention relative to the beginning of life (BOL) capacity. The sulfur-free control cell lasted less than 150 cycles above the 90% retention line. Electrochemical impedance spectroscopy (EIS) measurements for cycled cells showed lower interfacial resistance for cells with sulfur-containing additives compared to control cells. The reason for the improved cycle stability can be attributed to the stability afforded by the additives to the SEI layer. Figure 1: A comparison of cell performance between control (black) and sulfur-containing additive (green). The Red line indicates the 90% retention of the battery. References Yoshio, Masaki, Ralph J. Brodd, and Akiya Kozawa. Lithium-ion batteries. Vol. 1. New York: Springer, 2009. Liu, Bin, Ji-Guang Zhang, and Wu Xu. "Advancing lithium metal batteries." Joule2, no. 5 (2018): 833-845. Xiao, Jie, Qiuyan Li, Yujing Bi, Mei Cai, Bruce Dunn, Tobias Glossmann, Jun Liu et al. "Understanding and applying coulombic efficiency in lithium metal batteries." Nature Energy5, no. 8 (2020): 561-568. Tikekar, Mukul D., Snehashis Choudhury, Zhengyuan Tu, and Lynden A. Archer. "Design principles for electrolytes and interfaces for stable lithium-metal batteries." Nature Energy1, no. 9 (2016): 1-7. Wang, Qian, Chengkai Yang, Jijin Yang, Kai Wu, Cejun Hu, Jing Lu, Wen Liu, Xiaoming Sun, Jingyi Qiu, and Henghui Zhou. "Dendrite‐free lithium deposition via a superfilling mechanism for high‐performance Li‐metal batteries." Advanced Materials31, no. 41 (2019): 1903248. Choudhury, Snehashis. "Lithium fluoride additives for stable cycling of lithium batteries at high current densities." In Rational Design of Nanostructured Polymer Electrolytes and Solid–Liquid Interphases for Lithium Batteries, pp. 81-94. Springer, Cham, 2019. Yun, Qinbai, Yan‐Bing He, Wei Lv, Yan Zhao, Baohua Li, Feiyu Kang, and Quan‐Hong Yang. "Chemical dealloying derived 3D porous current collector for Li metal anodes." Advanced Materials28, no. 32 (2016): 6932-6939. Figure 1

In this paper, the influence of homeotropic and homogeneous orienting layers is presented in a cell filled with chiral nematic liquid crystals stabilized in a blue phase. The change of selective Bragg reflection from red to blue light was observed for homogeneous layers in rectangular geometries. The growth of blue phase crystals domains in a glass cell as well an influence of temperature and the electric field on such a structure, are also presented. Full Text: PDF ReferencesF. Reinitzer, Beitrage zur Kenntniss des Cholestherins, Monatsh Chem. 9, 421-441, (1888). CrossRef J. Yan, M. Jiao, L. Rao, and S.-T. Wu, "Direct measurement of electric-field-induced birefringence in a polymer-stabilized blue-phase liquid crystal composite", Opt. Express 18, 11450-11455 (2010) CrossRef Y. Chen, D. Xu, S.-T. Wu, S.-i. Yamamoto, Y. Haseba, "A low voltage and submillisecond-response polymer-stabilized blue phase liquid crystal", Appl. Phys. Lett. 102, 141116 (2013) CrossRef Y. Huang, H. Chen, G. Tan, H. Tobata, S. Yamamoto, E. Okabe, Y.-F. Lan, C.-Y. Tsai, and S.-T. Wu, "Optimized blue-phase liquid crystal for field-sequential-color displays", Opt. Mater. Express 7, 641-650 (2017) CrossRef V. Sridurai, M. Mathews, C. V. Yelamaggad, G. G. Nair, "Electrically Tunable Soft Photonic Gel Formed by Blue Phase Liquid Crystal for Switchable Color-Reflecting Mirror", ACS Appl. Mater. Interfaces, 9 (45), 39569-39575 (2017) CrossRef E. Oton, E. Netter, T. Nakano, Y. D.-Katayama, F. Inoue, "Monodomain Blue Phase Liquid Crystal Layers for Phase Modulation", Sci. Rep. vol.7, 44575 (2017) CrossRef Q. Liu, D. Luo, X. Zhang, S. Li, Z. Tian, "Refractive index and absorption coefficient of blue phase liquid crystal in terahertz band", Liq. Cryst., Vol. 44, No. 2, pp. 348-354 (2017) CrossRef Y. Li, Y. Liu, Q. Li, S.-T. Wu, "Polarization independent blue-phase liquid crystal cylindrical lens with a resistive film", Appl. Opt., Vol. 51, No. 14, pp. 2568-2572 (2012) CrossRef M. M. Sala-Tefelska, K. Orzechowski M. Sierakowski, A. Siarkowska, T.R. Woliński, O. Strzeżysz, P. Kula, "Influence of cylindrical geometry and alignment layers on the growth process and selective reflection of blue phase domains", Opt. Mater. 75, 211-215, (2018) CrossRef H. Claus, O. Willekens, O. Chojnowska, R. Dąbrowski, J. Beeckman, K. Neyts, "Inducing monodomain blue phase liquid crystals by long-lasting voltage application during temperature variation", Liq. Cryst. 43 (5), 688-693, (2016) CrossRef M. Takahashi, T. Ohkawa, H. Yoshida, J. Fukuda, H. Kikuchi, M. Ozaki, "Orientation of liquid crystalline blue phases on unidirectionally orienting surfaces", J. Phys. D: Appl. Phys. 51 (10), 104003 (2018) CrossRef P. Joshi, X. Shang, J. De Smet, E. Islamai, D. Cuypers, G. Van Steenberge, S. Van Vlierberghe, P. Dubruel, H. De Smet, "On the effect of alignment layers on blue phase liquid crystals", Appl. Phys. Lett. 106, 101105 (2015) CrossRef K. Orzechowski, M.W. Sierakowski, M. Sala-Tefelska, P. Joshi, T.R. Woliński, H.D. Smet, "Polarization properties of cubic blue phases of a cholesteric liquid crystal", Opt. Mater. 69, 259-264 (2017) CrossRef P.-J. Chen, M. Chen, S.-Y. Ni, H.-S. Chen, Y.-H. Lin, "Influence of alignment layers on crystal growth of polymer-stabilized blue phase liquid crystals", pt. Mater. Express 6, 1003-1010 (2016) CrossRef CrossRef

The growing demand for higher energy density batteries is increasing due to needs of electric vehicle (EV) [1]. Until now, it cannot exceed the one-time charging distance of an internal combustion engine vehicle, due to energy limit of batteries. Li metal anode (LMA) is one of the attractive anode candidates because of the lowest electrochemical redox electrode potential (-3.04 V vs. SHE) and the extremely high theoretical gravimetric capacity (3,860 mAh g-1) compared to graphite anode (372 mAh g-1) [2]. However, uneven Li deposition causes dendritic growth leading to low Coulombic efficiency (CE) and safety hazards which is impeding the practical use of LMAs [3]. Recently, to suppress such dendritic growth, various solutions such as introduction of solid-state electrolyte (SSE) [4], artificial solid electrolyte interphase (ASEI) [5], 3D current collector (CC) [6], and lithiophilic materials [7] have been proposed. Among the several approaches, introducing lithiophilic material on a CC is one of the facile and effective strategies to increase the lithiophilicity, and hence to induce the planar growth of Li. Also, assuming that electroplating is largely divided into two steps: nucleation and growth, lithiophilic material can change the intrinsic nucleation behavior by preferentially forming a different phases such as Li alloys [8]. Since the Li nucleation process significantly influences the final growth of Li, different cycling behaviors of LMAs would be expected depending on lithiophilic material [9]. As for the methods to adopt the lithiophilic materials, the electrodeposition is very attractive, since it can easily control the surface morphology, which might affect the Li deposition morphology and the related behavior. In this regard, we chose the tin (Sn) as a lithiophilic material, which can be deposited on Cu CC by electroplating, and moreover have a fast Li ion diffusion coefficient [10]. Specifically, in this work, we study the effect of surface morphology of lithiophilic Sn deposited on copper CC by testing Li deposition/stripping behavior for a LMAs. For different morphology, a direct current electrodeposition (DC) and pulsed electrodeposition (PED) were used. Fig.1 is FE-SEM images of Cu@Sn with DC growth and PED growth. Fig.1 (a) shows Sn particles are growing without filling the pores. However, Fig.1 (c) shows Sn particles are growing with filling the pores. At Fig.1 (b) and (d), the morphology difference is conspicuous between DC and PED growth. Fig.1 (b) presents island growth in which nuclei grow on existing nuclei because there is only Ton without relaxation time. While, Fig.1 (d) shows that after rearrangement of deposited atom at Toff, new nucleation sites are created by continuously applying pulses, thereby obtaining the coalescence growth. At Fig.2, Cu@Sn (PED) shows the longer cycle life than bare Cu and Cu@Sn (DC) because Cu@Sn (PED) has an uniformly distributed nano Sn morphology, which provides more sites for Li nucleation to prevent dendritic growth. References [1] PARAJULY, Keshav; TERNALD, Daniel; KUEHR, Ruediger. The Future of Electric Vehicles and Material Resources: A Foresight Brief. 2020. [2] XU, Wu, et al. Lithium metal anodes for rechargeable batteries. Energy & Environmental Science, 2014, 7.2: 513-537. [3] CHENG, Xin-Bing, et al. Toward safe lithium metal anode in rechargeable batteries: a review. Chemical reviews, 2017, 117.15: 10403-10473. [4] YU, Seungho, et al. Elastic properties of the solid electrolyte Li7La3Zr2O12 (LLZO). Chemistry of Materials, 2016, 28.1: 197-206. [5] LI, Nian‐Wu, et al. An artificial solid electrolyte interphase layer for stable lithium metal anodes. Advanced materials, 2016, 28.9: 1853-1858. [6] YUN, Qinbai, et al. Chemical dealloying derived 3D porous current collector for Li metal anodes. Advanced Materials, 2016, 28.32: 6932-6939. [7] YAN, Kai, et al. Selective deposition and stable encapsulation of lithium through heterogeneous seeded growth. Nature Energy, 2016, 1.3: 1-8. [8] PEI, Allen, et al. Nanoscale nucleation and growth of electrodeposited lithium metal. Nano letters, 2017, 17.2: 1132-1139. [9] CHEN, Xiao-Ru, et al. Role of Lithiophilic Metal Sites in Lithium Metal Anodes. Energy & Fuels, 2021, 35.15: 12746-12752. [10] SHI, Jianjian; WANG, Zhiguo; FU, Yong Qing. Density functional theory study of diffusion of lithium in Li–Sn alloys. Journal of materials science, 2016, 51.6: 3271-3276. [11] IBL, N.; SCHADEGG, K. Surface roughness effects in the electrodeposition of copper in the limiting current range. Journal of the Electrochemical Society, 1967, 114.1: 54. Figure 1

The paper is the first of a series, which aims to present a consistent interpretation of the suprageneric taxa of fossil beetles in the current century and their generic and species composition. Order Coleoptera is considered in composition of the superorder Coleopteroidea Handlirsch, 1903 (= Coleopterida sensu Boudreaux, 1979, nec Pearse, 1936) together with orders Skleroptera and Strepsiptera, and also with the family Umenocoleidae of unclear position. This paper includes the archostematan superfamilies Coleopseoidea and Cupedoidea of the infraorder Cupediformia, i.e., Coleopseidae (one genus and one species), Tshekardocoleidae (12 genera, 15 species), Labradorocoleidae (one genus, one species), Permocupedidae (together with Taldycupedinae, stat. nov., 24 genera and 54 species) and Cupedidae (three subfamilies, 49 genera, 253 species). The preliminary information on structure of the larva of Tshekardocoleidae from Tshekarda is done. There are also described the new taxa: genus Afrotaldycupes Kirejtshuk, gen. nov. with the type species: genus Taldycupes africanus Ponomarenko in Ponomarenko & Mostovski, 2005 [Afrotaldycupes africanus comb. nov.] and Afrotaldycupes lidgettoniensis (Ponomarenko in Ponomarenko & Mostovski, 2005), comb. nov. [Taldycupes]; genus Allophalerus Kirejtshuk, gen. nov. with the type species: Tetraphalerus aphaleratus Ponomarenko, 1969 [Allophalerus aphaleratus comb. nov.], and also with Allophalerus antiquus (Ponomarenko, 1964), comb. nov. [Tetraphalerus], Allophalerus bontsaganensis (Ponomarenko, 1997), comb. nov. [Tetraphalerus], Allophalerus incertus (Ponomarenko, 1969), comb. nov. [Tetraphalerus], Allophalerus latus (Tan, Ren et Shih, 2007), comb. nov. [Tetraphalerus], Allophalerus maximus (Ponomarenko, 1968), comb. nov. [Tetraphalerus], Allophalerus okhotensis (Ponomarenko, 1993), comb. nov. [Tetraphalerus], Allophalerus tenuipes (Ponomarenko, 1964), comb. nov. [Tetraphalerus], Allophalerus verrucosus (Ponomarenko, 1966), comb. nov. [Tetraphalerus]; genus Bukhkalius Kirejtshuk et Jarzembowski, gen. nov. with the type species: Tetraphalerus lindae Jarzembowski, Wang et Zheng, 2017 [Bukhkalius lindae comb. nov.]; genus Burmocoleus Kirejtshuk, gen. nov. with the type species: Burmocoleus prisnyi sp. nov. and Burmocoleus zhiyuani (Liu, Tan, Ślipiński, Jarzembowski, Wang, Ren et Pang, 2017), comb. nov. [Brochocoleus]; genus Cionocups Kirejtshuk, gen. nov. with the type species: Cionocups manukyani sp. nov.; genus Echinocups Kirejtshuk et Jarzembowski, gen. nov. with the type species: Notocupes neli Tihelka, Huang et Cai, 2020 [Echinocups neli comb. nov.], and also Echinocups ohmkuhnlei (Jarzembowski, Wang et Zheng, 2020), comb. nov. [Notocupes] and Echinocups denticollis (Jiang, Li, Song, Shi, Liu, Chen et Kong, 2020), comb. nov. [Notocupes]; genus Jarzembowskops Kirejtshuk, gen. nov. with the type species: Brochocoleus caseyi Jarzembowski, Wang et Zheng, 2016 [Jarzembowskops caseyi comb. nov.]; genus Lobanovia Kirejtshuk, gen. nov. with the type species: Simmondsia permiana Ponomarenko, 2013 [Lobanovia permiana comb. nov.]; genus Pintolla Kirejtshuk, gen. nov. with the type species: Kaltanicupes ponomarenkoi Pinto, 1987 [Pintolla ponomarenkoi comb. nov.]; genus Polyakius Kirejtshuk, gen. nov. with the type species: Polyakius alberti Kirejtshuk, sp. nov. and Polyakius pubescens Kirejtshuk, sp. nov.; Clessidromma zengi Kirejtshuk, sp. nov.; Cupes golovatchi Kirejtshuk, sp. nov.; Cupes legalovi Kirejtshuk, sp. nov.; Cupes lutzi Kirejtshuk, sp. nov.; Cupes nabozhenkoi Kirejtshuk, sp. nov.; Cupes wedmannae Kirejtshuk, sp. nov.; Mallecupes prokini Kirejtshuk, sp. nov. and Omma janetae Kirejtshuk, sp. nov. The new synonymy is established for the generic names Clessidromma Jarzembowski, Wang et Zheng, 2017 and Lepidomma Jarzembowski, Wang et Zheng, 2019, syn. nov. The rank of Cainomerga A. Kirejtshuk, Nel et P. Kirejtshuk, 2016 is elevated from subgeneric to generic. Also other new combinations are proposed: Cainomerga brevicornis (A. Kirejtshuk, Nel et P. Kirejtshuk, 2016), comb. nov. [Mesocupes], Cainomerga fraterna (A. Kirejtshuk, Nel et P. Kirejtshuk, 2016), comb. nov. [Mesocupes], Cainomerga immaculata (Piton, 1940: 194), comb. nov. [Zonabris, Mesocupes], Cainomerga palaeocenica (A. Kirejtshuk, Nel et P. Kirejtshuk, 2016), comb. nov. [Mesocupes], and Cainomerga ponti (A. Kirejtshuk, Nel et P. Kirejtshuk, 2016), comb. nov. [Mesocupes], Clessidromma tianae (Jarzembowski, Wang et Zheng, 2019), comb. nov. [Lepidomma], Diluticupes applanatus (Tan et Ren, 2009), comb. nov. [Brochocoleus], Diluticupes crowsonae (Jarzembowski, Yan, Wang et Zhang. 2013), comb. nov. [Brochocoleus], Diluticupes magnus (Tan et Ren, 2009), comb. nov. [Brochocoleus], Diluticupes minor (Ponomarenko, 2000), comb. nov. [Brochocoleus], Diluticupes validus (Tan et Ren, 2009), comb. nov. [Brochocoleus], Diluticupes yangshuwanziensis (Jarzembowski, Yan, Wang et Zhang. 2013), comb. nov. [Brochocoleus], Monticupes curtinervis (Tan, Ren et Shih, 2007), comb. nov. [Tetraphalerus], Monticupes decorosus (Tan, Wang, Ren et Yang, 2012), comb. nov. [Tetraphalerus], Odontomma sulcatum (Tan, Ren et Shih, 2007), comb. nov. [Brochocoleus], Omma ancistrodontum (Tan, Wang, Ren et Yang, 2012), comb. nov. [Pareuryomma], Omma grande (Ponomarenko, 1964), comb. nov. [Tetraphalerus], Omma longicolle (Ponomarenko, 1997), comb. nov. [Tetraphalerus], Pareuryomma angustum (Tan, Ren et Shich, 2007), comb. nov. [Brochocoleus], Pareuryomma magnum (Tan et Ren, 2009), comb. nov. [Brochocoleus], Zygadenia aliena (Tan et Ren, 2006), comb. nov. [Ovatocupes], Zygadenia baojiatunensis (Hong 1992), comb. nov. [Chengdecupes], Zygadenia brachycephala (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia caduca (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia caudata (Ponomarenko, 1966), comb. nov. [Notocupes], Zygadenia cellulosa (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia crassa (Ponomarenko, 1969), comb. nov., [Notocupes], Zygadenia cyclodontus (Tan, Ren, Shih et Ge, 2006), comb. nov. [Amblomma, Notocupes], Zygadenia dischdes (Zhang, 1986), comb. nov. [Notocupes], Notocupes dundulaensis (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia elegans (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia epicharis (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], Zygadenia eumeura (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], Zygadenia excellens (Ponomarenko, 1966), comb. nov. [Notocupes], Zygadenia exigua (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia foersteri (Ponomarenko, 1971), comb. nov. [Procarabus, Notocupes], Zygadenia homora (Lin, 1986), comb. nov. [Conexicoxa, Notocupes], Zygadenia issykkulensis (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia jurassica (Hong 1983), comb. nov. [Chengdecupes], Zygadenia kezuoensis (Hong 1987), comb. nov. [Chengdecupes], Zygadenia khasurtuiensis (Strelnikova, 2019), comb. nov. [Notocupes], Zygadenia khetanensis (Ponomarenko, 1993), comb. nov. [Notocupes], Zygadenia kirghizica (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia laeta (Lin, 1976), [Tetraphalerus], Zygadenia laiyangensis (Hong et Wang, 1990), comb. nov. [Forticupes, Notocupes], Zygadenia lapidaria (Ponomarenko, 1968), comb. nov. [Notocupes], Zygadenia laticella (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia lata (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia lenta (Ren, Lu, Guo et Ji, 1995), comb. nov. [Tetraphalerus], Zygadenia lini (Ponomarenko, Yan, Wang et Zhang, 2012), comb. nov. [Notocupes], Zygadenia longicollis (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia ludongensis (Wang et Liu, 1996), comb. nov. [Notocupes], Zygadenia minuscula (Tan, Ren, Shih et Ge, 2006), comb. nov. [Amblomma, Notocupes], Zygadenia mongolica (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia nigrimonticola (Ponomarenko, 1968), comb. nov. [Notocupes], Zygadenia oxypyga (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia patula (Ponomarenko, 1985), comb. nov. [Notocupes], Zygadenia pingi (Ponomarenko et Ren, 2010), comb. nov. [Notocupes], Zygadenia porrecta (Tan, Ren, Shih et Ge, 2006), comb. nov. [Amblomma, Notocupes], Zygadenia protensa (Tan, Ren, Shih et Ge, 2006), comb. nov. [Amblomma, Notocupes], Zygodenia psilata (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], , Zygadenia pulchra Ponomarenko, 1968, comb. nov. [Notocupes], Zygadenia reticulata (Oppenheim, 1888), comb. nov. [Procarabus, Notocupes], Notocupes rostrata (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia rudis (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], Zygadenia shiluoensis (Hong 1984), comb. nov. [Chengdecupes], Zygadenia sogutensis (Ponomarenko, 1969), comb. nov., Zygadenia stabilis (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], Zygadenia tenuis (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia tripartita (Oppenheim, 1888), comb. nov. [Procarabus, Notocupes], Zygadenia tuanwangensis (Hong et Wang, 1990), comb. nov. [Picticupes, Notocupes], Zygadenia valida (Lin, 1976), comb. nov. [Sinocupes, Notocupes], Zygadenia vitimensis (Ponomarenko, 1966), comb. nov. [Notocupes].

Tin (Sn) is a metal that is commonly used in our daily life. With the rapid development of lithium-ion battery in the past decades, Sn and its alloy, such as Sn-Cu[1], and Sn-Ni[2], Sn-Co[3] and Sn-Fe[4] have been used as anode for lithium-ion battery because they can undergo alloying/dealloying process with lithium ions and exhibit high capacity and suitable working voltage of about 0.4 V vs. Li/Li+. Sn can also undergo an oxidation reaction to Sn2+, with an electrode potential of about -0.14 V vs. SHE. It is therefore possible to also use Sn as a cathode material. Herein, we are first to demonstrate a metal-metal battery made up of Sn metal as the cathode and Li metal as the anode in organic electrolyte (see Fig. a). Sn foil and Li foil are simply assembled with 3M LiTFSI in dimethoxyethane/propylene carbonate (DME/PC) electrolyte in an Ar-filled glove box to form a pouch cell. During charging, Sn will give out two electrons and dissolves into the electrolyte as Sn2+, while during discharging, the metal ions will be re-deposited onto the cathode. Thus, the energy is stored in the form of Sn2+ in the electrolyte. The charge-discharge curves in Fig. b show that the operating voltage of the battery is about 2.8 V. Since Sn2+ that is dissolved into the electrolyte from the cathode has higher potential than the Li metal anode, any Sn2+ ions cross-over to the anode will be spontaneously reduced, decreasing the efficiency of the battery. To suppress such self-discharge process, an anion exchange membrane based on poly(ionic liquid) polymer coated on common polypropylene separator is adopted. The Sn-Li battery with the modified separator tested in a current rate of 0.2 mA cm-2 with a capacity limitation of 0.1 mAh cm-2 gives an average Coulombic efficiency about 99.5% and can be cycled for more than 1500 cycles(See Fig. c). We found that the stripping/deposition of Sn on the cathode, and its polarization depend strongly on the type of electrolyte used. With 3M LiTFSI in DME/PC electrolyte, the discharge voltage is lowered by about 0.05 V when the current density is increased from 0.2 mA cm-2 to 1 mA cm-2. More results on the factors affecting the charge-discharge performance of Sn-Li batteries will be discussed at the meeting. [1]X. F. Tan, S. D. McDonald, Q. Gu, Y. Hu, L. Wang, S. Matsumura, T. Nishimura, K. Nogita, Journal of Power Sources 2019, 415, 50. [2]H. Zhang, T. Shi, D. J. Wetzel, R. G. Nuzzo, P. V. Braun, Advanced Materials 2016, 28, 742. [3]J. Yang, J. Zhang, X. Zhou, Y. Ren, M. Jiang, J. Tang, ACS Applied Materials & Interfaces 2018, 10, 35216. [4]Z. Lin, X. Lan, X. Xiong, R. Hu, Materials Chemistry Frontiers 2021, 5, 1185. Figure 1

BackgroundColorectal cancer is a heterogeneous disease with complicated genetic alterations. Right colon and left colon have different features while right colon cancer displays an even worse prognosis. The randomized phase III FOxTROT trial demonstrated better downstaging effect with neoadjuvant plus adjuvant chemotherapy compared with adjuvant chemotherapy alone (P=0.04).1 Moreover, 2-year relapse rate was improved with neoadjuvant therapy, though the difference was not statistically significant. The NICHE study of neoadjuvant immunotherapy (maximum 6 weeks) showed that the pathological response was observed in 20/20 mismatch repair-deficient (dMMR) resectable colon cancers, with 19 major pathological responses and 12 pathological complete responses (pCRs).2 Recently, KEYNOTE-177 study showed improved progression-free survival with PD-1 inhibitor over chemotherapy (16.5 months vs. 8.2 months) in untreated microsatellite instability-high (MSI-H)/dMMR colon cancer patients, including 68% of right colon cancers.3 In addition, camrelizumab (PD-1 inhibitor) plus apatinib (vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor) demonstrated favorable antitumor effects and a manageable safety profile in advanced hepatocellular carcinoma and gastric cancer.4 5 This phase II trial aims to explore whether the combination of camrelizumab, apatinib and chemotherapy (mFOLFOX6) could significantly improve the pathological regression rate in locally advanced right colon cancer so as to bring considerable survival benefit for patients.MethodsEligible patients are aged 18–75 years, with locally advanced (T4 or T3 with extramural depth ≥5 mm, N0-2, M0, AJCC 8th) adenocarcinoma of right colon (including ileocecal area, ascending colon, and transverse colon to splenic flexion), and without prior systemic chemotherapy or immunotherapy. All patients will receive 5 cycles of camrelizumab (200 mg once every 2 weeks) plus mFOLFOX6 and 2 months of apatinib (250 mg orally once a day), followed by surgery and 7 cycles of adjuvant camrelizumab plus mFOLFOX6. The primary endpoint is the proportion of patients with tumor regression grade (TRG) 2–4 according to the Dworak criteria (TRG2: dominantly fibrotic changes with few tumor cells or groups; TRG3: very few tumor cells in fibrotic tissue; TRG4: no tumor cells). Secondary endpoints include downstaging rate, pCR rate, R0 resection rate, 2-year disease-free survival rate, 2-year event-free survival, overall survival, quality of life, and safety.ResultsTo date, three of planned 64 patients have been enrolled. Two patients have completed surgery. According to Dworak criteria, TRG ranked 4 (pathologic complete response) for the first patient and 3 (very few tumor cells in fibrotic tissue) for the second patient. No severe adverse events have been observed for all patients.Trial RegistrationThis trial has been registered at ClinicalTrials.gov (NCT04625803).ReferencesG. Foxtrot Collaborative. Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial. Lancet Oncol 13(11) (2012):1152–60.Chalabi M, Fanchi LF, Dijkstra KK, Van den Berg JG, Aalbers AG, Sikorska K, Lopez-Yurda M, Grootscholten C, Beets GL, Snaebjornsson P, Maas M, Mertz M, Veninga V, Bounova G, Broeks A, Beets-Tan RG, de Wijkerslooth TR, van Lent AU, Marsman HA, Nuijten E, Kok NF, Kuiper M, Verbeek WH, Kok M, Van Leerdam ME, Schumacher TN, Voest EE, Haanen JB. Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers. Nat Med 26(4) (2020):566–576.André T, Shiu KK, Kim TW, Jensen BV, Jensen LH, Punt C, Smith D, Garcia-Carbonero R, Benavides M, Gibbs P, de la Fouchardiere C, Rivera F, Elez E, Bendell J, Le DT, Yoshino T, Van Cutsem E, Yang P, Farooqui MZH, Marinello P, Diaz Jr LA. Pembrolizumab in microsatellite-instability-high advanced colorectal cancer. N Engl J Med 383(23) (2020):2207–2218.Xu J, Shen J, Gu S, Zhang Y, Wu L, Wu J, Shao G, Zhang Y, Xu L, Yin T, Liu J, Ren Z, Xiong J, Mao X, Zhang L, Yang J, Li L, Chen X, Wang Z, Gu K, Chen X, Pan Z, Ma K, Zhou X, Yu Z, Li E, Yin G, Zhang X, Wang S, Wang Q. Camrelizumab in combination with apatinib in patients with advanced hepatocellular carcinoma (RESCUE): a nonrandomized, open-label, phase II trial. Clin Cancer Res 27(4) (2021):1003–1011.Xu J, Shen J, Gu S, Zhang Y, Wu L, Wu J, Shao G, Zhang Y, Xu L, Yin T, Liu J, Ren Z, Xiong J, Mao X, Zhang L, Yang J, Li L, Chen X, Wang Z, Gu K, Chen X, Pan Z, Ma K, Zhou X, Yu Z, Li E, Yin G, Zhang X, Wang S, Wang Q, Xu J, Zhang Y, Jia R, Yue C, Chang L, Liu R, Zhang G, Zhao C, Zhang Y, Chen C, Wang Y, Yi X, Hu Z, Zou J, Wang Q. Camrelizumab in combination with apatinib in patients with advanced hepatocellular carcinoma (RESCUE): a nonrandomized, open-label, phase II trial anti-PD-1 antibody SHR-1210 combined with apatinib for advanced hepatocellular carcinoma, gastric, or esophagogastric junction cancer: an open-label, dose escalation and expansion study. Clin Cancer Res 27(4) (2021):1003–1011.Ethics ApprovalStudy protocol was approved by the Clinical Research Ethics Committee of the First Affiliated Hospital, College of Medicine, Zhejiang University (2020–119)ConsentWritten informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.

Objetivo: Esse estudo objetivou investigar percepções de estudantes de Odontologia quanto ao medo e à ansiedade em relação ao manejo de pacientes e ao risco de infecção por COVID-19. Materiais e métodos: Esse estudo transversal envolveu todos os alunos regularmente matriculados em Odontologia, no primeiro semestre de 2020, da Universidade Federal de Pelotas. Um questionário foi aplicado, coletando dados demográficos, nível de formação e perguntas relacionadas ao medo e ansiedade frente à pandemia de COVID-19. Quatro comparações de acordo com a fase da graduação (fase pré-clínica ou clínica), nível de graduação e pós-graduação e de acordo com os sexos foram feitas. Análises independentes para as comparações entre os sexos foram realizadas para os alunos de graduação e de pós-graduação (α<5%). Resultados: Foram incluídos 408 estudantes. Na graduação, mulheres relataram sentirem-se mais ansiosas ao realizar tratamento em pacientes com suspeita de COVID-19 (54%) e sentem mais medo ao ouvir que a infecção tem causado mortes (92,4%), na pós-graduação, responderam ser mais nervosas para conversar com pacientes em ambientes fechados em comparações com homens (P<0,05). Alunos em fase pré-clínica possuem significativamente menor receio (65,5%), ansiedade (32,3%) e nervosismo (28,3%) do contágio do COVID-19 quando comparados com aqueles na fase clínica. Conclusões: Mulheres e alunos na fase clínica apresentam maior ansiedade e nervosismo. Descritores: Ansiedade; Estudantes de Odontologia; Medo; Infecções por Coronavírus. Referências Chang J, Yuan Y, Wang D. [Mental health status and its influencing factors among college students during the epidemic of COVID-19]. Nan Fang Yi Ke Da Xue Xue Bao. 2020;40(2):171-176. World Health Organization. WHO Director-General’s opening remarks at the media briefing on COVID-19- 11 March 2020. 2020. Disponível em: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020. Acesso em: 8 de novembro de 2020. Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, Scarlata S, Agrò FE. COVID-19 diagnosis and management: a comprehensive review. J Intern Med. 2020;288(2):192-206. Chen E, Lerman K, Ferrara E. Tracking Social Media Discourse About the COVID-19 Pandemic: Development of a Public Coronavirus Twitter Data Set. JMIR Public Health Surveill. 2020;6(2):e19273. Iyer P, Aziz K, Ojcius DM. Impact of COVID-19 on dental education in the United States. J Dent Educ. 2020;84(6):718-722. Meng L, Hua F, Bian Z. Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. J Dent Res. 2020;99(5):481-487. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci. 2020;12(1):9. Machado RA, Bonan PRF, Perez DEDC, Martelli Júnior H. COVID-19 pandemic and the impact on dental education: discussing current and future perspectives. Braz Oral Res. 2020;34:e083. Ataş O, Talo Yildirim T. Evaluation of knowledge, attitudes, and clinical education of dental students about COVID-19 pandemic. PeerJ. 2020;8:e9575. Deery C. The COVID-19 pandemic: implications for dental education. Evid Based Dent. 2020;21(2):46-47. Basudan S, Binanzan N, Alhassan A. Depression, anxiety and stress in dental students. Int J Med Educ. 2017;8:179-186. Elani HW, Allison PJ, Kumar RA, Mancini L, Lambrou A, Bedos C. A systematic review of stress in dental students. J Dent Educ. 2014; 78(2):226-42. Sahu P. Closure of Universities Due to Coronavirus Disease 2019 (COVID-19): Impact on Education and Mental Health of Students and Academic Staff. Cureus. 2020;12(4):e7541. Ahmed MA, Jouhar R, Ahmed N, Adnan S, Aftab M, Zafar MS, Khurshid Z. Fear and Practice Modifications among Dentists to Combat Novel Coronavirus Disease (COVID-19) Outbreak. Int J Environ Res Public Health. 2020;17(8):2821. Talevi D, Socci V, Carai M, Carnaghi G, Faleri S, Trebbi E, di Bernardo A, Capelli F, Pacitti F. Mental health outcomes of the CoViD-19 pandemic. Riv Psichiatr. 2020;55(3):137-44. Mijiritsky E, Hamama-Raz Y, Liu F, Datarkar AN, Mangani L, Caplan J, Shacham A, Kolerman R, Mijiritsky O, Ben-Ezra M, Shacham M. Subjective Overload and Psychological Distress among Dentists during COVID-19. Int J Environ Res Public Health. 2020;17:5074. Rymarowicz J, Stefura T, Major P, Szeliga J, Wallner G, Nowakowski M, Pędziwiatr M. General surgeons' attitudes towards COVID-19: A national survey during the SARS-CoV-2 virus outbreak. Eur Surg. 2020;1-6. Adams JG, Walls RM. Supporting the Health Care Workforce During the COVID-19 Global Epidemic. JAMA. 2020;323(15):1439-40. Naz N, Iqbal S, Mahmood A. Stress, anxiety and depression among the dental students of university college of medicine and dentistry Lahore; Pakistan. Pak J Med Health Sci. 2017;11(4):1277-81. Waqas A, Iftikhar A, Malik Z, Aedma KK, Meraj H, Naveed S. Association of severity of depressive symptoms with sleep quality, social support and stress among Pakistani medical and dental students: A cross-sectional study. Global Psychiatry. 2019;2(2):211-20. Wang Y, Di Y, Ye J, Wei W. Study on the public psychological states and its related factors during the outbreak of coronavirus disease 2019 (COVID-19) in some regions of China. Psychol Health Med. 2020;1-10. Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, Chen-Li D, Iacobucci M, Ho R, Majeed A, McIntyre RS. Impact of COVID-19 pandemic on mental health in the general population: A systematic review. J Affect Disord. 2020;277:55-64. Liu N, Zhang F, Wei C, Jia Y, Shang Z, Sun L, Wu L, Sun Z, Zhou Y, Wang Y, Liu W. Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: Gender differences matter. Psychiatry Res. 2020;287;112921. Terán E, Mayta-Tovalino F. Risk Factors, Self-perceived Stress, and Clinical Training among Dentistry Students in Peru: A Cross-sectional Study. J Contemp Dent Pract. 2019;20(5):561-5. Uraz A, Tocak YS, Yozgatligil C, Cetiner S, Bal B. Psychological well-being, health, and stress sources in Turkish dental students. J Dent Educ. 2013:77(10):1345-55. Agius AM, Gatt G, Vento Zahra E, Busuttil A, Gainza-Cirauqui ML, Cortes ARG et al. Self-reported dental student stressors and experiences during the COVID-19 pandemic. J Dent Educ. 2020. doi: 10.1002/jdd.12409. Hu J, Zou H, Dai Y, Feng Z. How to keep students engaged in oral health education during the COVID-19 pandemic. J Dent Educ. 2020. doi: 10.1002/jdd.12420. Liu S, Yang L, Zhang C, Xiang YT, Liu Z, Hu S, Zhang B. Online mental health services in China during the COVID-19 outbreak. Lancet Psychiatry. 2020;7(4):e17-8. Maia BR, Dias PC. Anxiety, depression and stress in university students: the impact of COVID-19. Estudos de Psicologia (Campinas). 2020;37:e200067.

Purpose – This study examines whether the export intensity of firms listed in the Korean market is affected by environmental, social and governance (ESG) ratings. We test whether the environmental, social, and governance (ESG) performance in ratings of Korean firms can improve their export intensity in the global markets. Design/Methodology/Approach – In this study, we introduce ESG ratings, export intensity and other control variables in the models using unbalanced panel data of 1,974 firms listed on the KOSPI and KOSDAQ Exchange between 2012 and 2021 from a merged dataset of the KIS-VALUE and TS-2000 databases. We apply the fixed effects model (FEMs) after applying the Hausman and Lagrangian multiplier tests. Also, we apply instrument variable regressions (IV regressions) to control endogeneity in ESG ratings affected by other factors introduced. Findings – First, higher ESG ratings of the firms have a significantly negative effect on export intensity, which is inconsistent with the results of the previous research (Herding and Poncet, 2014). Second, ESG ratings of chaebol firms do not significantly reduce export intensity. The results might be due to the less severe constraints in chaebol firms by ESG costs. (Chaney, 2008; Shi Xin-Zheng and Xu Zhu-Feng, 2018). Third, each ESG rating, E, S, and G individually, shows a significantly negative effect on export intensity for only non-chaebol firms, while such an effect for chaebol firms is not statistically significant. Fourth, using the instrument variable regression, we have verified the result that ESG performance has a negative effect on firms' export intensity. Research Implications – This study is the first to examine the relationship between the ESG ratings of Korean firms and their export intensity, whose result is different from that of a prior study regarding Chinese firms (Wu Qing-Lan, Chen Gui-Fu, Han Jing and Wu Li-Yan, 2022). The negative effects of ESG ratings in Korea on exports for non-chaebol firms suggest that higher ESG ratings of Korean firms are not favorably accepted by their counterparts in the global markets while their efforts to get or enhance higher ratings incurring more expenses might hurt their competence in the global markets. Such negative effects of ESG ratings are not clearly observed for chaebol affiliated firms.

Abstract Background: METex14 mutations was reported in 3~4% of NSCLC patients and became a new target in the treatment of NSCLC. SCC244 is a highly selective and potent oral MET inhibitor. This is the first report of data from an ongoing single-arm phase II study of SCC244 in NSCLC patients with METex14 mutations (GLORY study). Methods: GLORY study is an open label, international, multi-center, single-arm phase II study to evaluate the efficacy and safety of SCC244 in patients with locally advanced or metastatic NSCLC harboring METex14 mutations which was confirmed by central laboratory. The enrolled patients have either failed one or two prior lines of systemic therapies or been not eligible/refused chemotherapy after being well-informed. SCC244 was taken orally at a dose of 300 mg once daily in 21-day treatment cycles until disease progression or intolerable toxicity. Tumor was evaluated every 6 weeks for the first 8 treatment cycles and every 9 weeks thereafter. The primary endpoint was objective response rate (ORR) assessed by blinded independent review committee (BIRC) per RECIST 1.1, secondary endpoints include ORR by investigator assessment (INV), duration of response (DoR), time to response (TTR) and safety etc. Post-hoc analysis was done to explore the intracranial anti-tumor activity. Results: At data cut-off on May 6th, 2021, a total 73 patients screened from 163 patients in 42 sites were treated at 300 mg QD dose and had ≥2 post-baseline tumor assessments or discontinued for any reason. 69 of them were with METex14 mutation confirmed by central laboratory. In the 69 patients, ORR by BIRC was 60.9% (95% CI: 48.4%, 72.4%) overall, 66.7% (95% CI: 50.5, 80.4) and 51.9% (95% CI: 31.9, 71.3) in treatment naïve and previously treated patients respectively. Median DoR was 8.2 months (95% CI: 4.8, NE) and median PFS was 7.6 months (95% CI: 4.2, NE), tumor response from 30 of 42 responders was still ongoing. The response occurred fast with a median TTR of 1.4 months (range: 1.2, 4.2). Partial response was observed in 8 of 10 patients with brain metastasis. 5 patients who had brain metastasis selected as targeted lesion had intracranial response by INV with a median intracranial tumor shrinkage of 57% (range: 34%, 71%). The most common (≥20%) treatment-related adverse events (TRAEs) of any grade were peripheral edema, headache, nausea, loss of appetite, hypoalbuminemia, ALT increase and vomiting. The incidence of ≥ grade 3 TRAEs was 43.8%. TRAEs leading to treatment discontinuation occurred in 6.8% patients, among which peripheral edema was the most common (4.1%). Conclusions: The data shows high and robust efficacy of SCC244 in NSCLC patients with METex14 mutations across treatment lines and encouraging intracranial anti-tumor activity. The safety profile was favorable with manageable toxicity. The data supports SCC244 as a valuable targeted treatment option for METex14 NSCLC patients. Citation Format: Shun Lu, Yongfeng Yu, Jianya Zhou, Koichi Goto, Xingya Li, Jun Sakakibara-Konishi, Kazumi Nishino, Tanaka Kentaro, Lin Wu, Xuhong Min, Wei Zhang, Dingzhi Huang, Yongqian Shu, Chengzhi Zhou, Min Li, Xiaorong Dong, Chong Bai, Lu Li, Jiuwei Cui, Li Zhang, Lejie Cao, Xiaoling Li, AiMin Zang, Haruki Kobayashi, Yiping Zhang, Yan Yu, Xiuwen Wang, Terufumi Kato, Shoichiro Yamamoto, Yuki Shinno, Xiaoyan Lin, Yanqiu Zhao, Yanping Hu, Qitao Yu, Ziping Wang, Masahiro Kodani, Jian Fang, Jialei Wang, Meiqi Shi, Diansheng Zhong, Wen Dong, Hiroshi Tanaka, Yasuto Yoneshima, Minghui Sun, Jun Zhou, Qiuxia Wu, Meng Li. Phase II study of SCC244 in NSCLC patients harboring MET exon 14 skipping (METex14) mutations (GLORY study) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT034.

Abstract KRAS mutations are frequently found in various types of cancers with an overall mutation frequency of 19.3%. G12C mutation of KRAS (KRASG12C) represents 11.4% of all KRAS mutations in cancer. Targeting KRAS mutations as a cancer treatment strategy has long been investigated for over 30 years already but still remains unconquered field. XNW14010 is a highly selective KRASG12C inhibitor that is rationally designed from AMG510, another proven covalent inhibitor of KRASG12C with potential antineoplastic activity. Compared to AMG510, XNW14010 demonstrated a better pharmaceutical potential and a better safety profile. XNW14010 does not have an axial chiral center shown in AMG510, thus the production cost of this agent could be vastly reduced. The in vitro efficacy of XNW14010 was tested in a variety of cancer cell lines with either wild type KRAS or different mutant KRAS, including lung cancer, colorectal cancer, and pancreatic cancer. The result shows that XNW14010 potently inhibits the activity of KRASG12C, but not wild type KRAS or KRAS bearing other mutations. Specifically, in a pancreatic cancer cell line MIA PaCa-2, which bears KRASG12C, the IC50 of XNW14010 is 26 nM. Furthermore, XNW14010 demonstrated a much less plasma protein binding (PPB) than AMG510 (50.4% versus 93.2%, respectively), suggesting much great potential to penetrating into tumor tissue for XNW14010 compared to AMG510. XNW14010 exhibited comparable or superior pharmacokinetic characteristics compared to AMG510 after oral administration in animal studies. More interestingly, XNW14010 has an improved brain penetration capability. The brain/plasma ratio of XNW14010 exposure is two folds as high as that of AMG510 and the Cmax of XNW14010 in brain tissue is also much higher. XNW14010 had a wider therapeutic window and good tolerance compared to AMG510, both in mouse and dog models, suggesting potentially better safety profile in humans. We also compared the antineoplastic activity of XNW14010 with that of AMG510 in vivo in Xenograft mouse models including lung cancer, colorectal cancer, and pancreatic cancer. The results demonstrated that XNW14010 has comparable antineoplastic activities to AMG510 when administered at the same doses. In pancreatic cancer, the total growth inhibition (TGI) is 90% when administered at the dose of 10 mg/kg QD. Given the better PPB, superior brain penetrating capacity, and similar antineoplastic activitie of XNW14010 compared to AMG510 in non-clinical studies, XNW14010 is expected to be a potent therapeutic candidate in treating cancers bearing KRASG12C, including pancreatic cancer. Citation Format: Yonghan Hu, Xin Li, Bin Huang, Liang Kong, Meijie Le, Yan Li, Cungang Liu, Xiaojun Liu, Bin Qian, Jing Qiang, Qifeng Shi, Wengui Wang, Yuchuan Wu, Zhenwei Wu, Linfeng Xu, Jinfeng Zhao. XNW14010:A highly selective KRASG12C inhibitor with potent efficacy in animal model of pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr A071.

Lithium-ion batteries (LIBs) and alkaline batteries have been widely used in electric vehicles and portable electronics, dominating the energy storage market for decades,[1] but their recycling/upcycling has lagged far behind. Re/up-cycling batteries is urgently needed because it can not only preserve raw materials such as Li, Co, Ni, Mn, Al, and Cu for LIBs as well as Zn, Mn, Fe for alkaline batteries but also reduce hazardous wastes towards the environment.[2] Despite previous efforts made on re/up-cycling LIBs and alkaline batteries, there remains an urgent demand for simple, economic, environmentally benign, and energy-saving approaches. For LIB recycling, the dominated recycling methods including pyrometallurgy and hydrometallurgy are destructive and criticized of high energy consumption, undesirable economic outputs, and water contamination. By contrast, non-destructive methods such as solid-state sintering[3] and hydrothermal treatment coupled with short annealing (HT-SA) [4-5]are more promising. However, these emerged direct recycling approaches are deficient at regenerating outdated cathode materials to meet current market need. As such, upcycling (i.e., upgraded regeneration of cathodes) through surface engineering (coating[6] and doping[7-9]) or bulk reconstruction[10] has been developed. In our work, we demonstrate one upcycling approach to regenerate LiCoO2 cathode through an improved HT-SA approach in which a coating layer is prepared accompanied with the regeneration process. The upcycled cathode material shows improved electrochemical performance surpassing the pristine electrode materials. For alkaline battery recycling, the major recycling still focuses on hydrometallurgy and pyrometallurgy. Hydrometallurgical processes generally follow different steps of pre-treatment and subsequent leaching and separation of different metals by electrolysis, extraction or precipitation.[11] Another approach for treating spent alkaline battery materials is upcycling towards other applications such as supercapacitors,[12] catalysis[13], micronutrient fertilizer,[14] Mn alloy fabrication.[14] In our work, for the first time, we directly upcycle both zinc anode and Mn-based cathode for their use in rechargeable Zn-MnO2 batteries by a simple yet efficient annealing procedure. Zn was regenerated in a reductive atmosphere and the regenerated Zn shows high Coulombic efficiency and long life in symmetric cells while the regenerated Mn-based cathode shows superior performance than fresh MnO2 with regards to capacity, rate, and life. Under optimized N/P ratio, the regenerated Zn and MnO2 was paired to make rechargeable Zn-MnO2 batteries delivering excellent performance, comparable or even superior to state-of-the-art Zn-MnO2 batteries. Reference [1] Li, M.; Lu, J.; Chen, Z.; Amine, K.Advanced Materials 2018, 30, 1800561. [2] Rarotra, S.; Sahu, S.; Kumar, P.; Kim, K.-H.; Tsang, Y. F.; Kumar, V.; Kumar, P.; Srinivasan, M.; Veksha, A.; Lisak, G. ChemistrySelect 2020, 5, 6182. [3] Fan, M.; Chang, X.; Guo, Y.-J.; Chen, W.-P.; Yin, Y.-X.; Yang, X.; Meng, Q.; Wan, L.-J.; Guo, Y.-G., Energy Environ. Sci. 2021, 14 (3), 1461-1468. [4] Xu, P.; Dai, Q.; Gao, H.; Liu, H.; Zhang, M.; Li, M.; Chen, Y.; An, K.; Meng, Y. S.; Liu, P.; Li, Y.; Spangenberger, J. S.; Gaines, L.; Lu, J.; Chen, Z., Joule 2020, 4 (12), 2609-2626. [5] Shi, Y.; Chen, G.; Liu, F.; Yue, X.; Chen, Z., ACS Energy Lett. 2018, 3 (7), 1683-1692. [6] Meng, X.; Cao, H.; Hao, J.; Ning, P.; Xu, G.; Sun, Z., ACS Sustain. Chem. Eng. 2018, 6 (5), 5797-5805. [7] Wu, J.; Lin, J.; Fan, E.; Chen, R.; Wu, F.; Li, L., ACS Appl. Energy Mater. 2021, 4 (3), 2607-2615. [8] Fan, X.; Tan, C.; Li, Y.; Chen, Z.; Li, Y.; Huang, Y.; Pan, Q.; Zheng, F.; Wang, H.; Li, Q. J. Hazard. Mater. 2021, 410, 124610. [9] Xu, B.; Dong, P.; Duan, J.; Wang, D.; Huang, X.; Zhang, Y., Ceram. Int. 2019, 45 (9), 11792-11801. [10] Gaines, L.; Dai, Q.; Vaughey, J. T.; Gillard, S. Recycling 2021, 6 (2). [11] Ferella, F.; De Michelis, I.; Vegliò, F. Journal of Power Sources 2008, 183, 805. [12] Farzana, R.; Hassan, K.; Sahajwalla, V.Scientific Reports 2019, 9, 8982. [13] Gallegos, M. V.; Falco, L. R.; Peluso, M. A.; Sambeth, J. E.; Thomas, H. J.Waste Management 2013, 33, 1483. [14] Hu, X.; Robles, A.; Vikström, T.; Väänänen, P.; Zackrisson, M.; Ye, G., Journal of Hazardous Materials 2021, 411, 124928.

Nature is an excellent source of inspiration for the widespread application of science and technology. Researchers learn from biological principles and gradually develop from the earliest direct use of biological materials to the design and development of new biomimetic materials inspired by nature. Therefore, the innovation of bioinspired nanomaterials will enable tremendous advances in biology and biochemistry with biomimetic capabilities, such as biosensing, cell imaging, and drug delivery. In this presentation, I will discuss my group’s recent work on two bioinspired nanomaterials: nano-peptoids and single-atom nanozymes. The first type of bioinspired materials is a sequence-defined peptide-like materials that can mimic the structure and function of peptides and proteins. Compared with peptides and proteins, peptoids have a high degree of thermal and chemical stability, and are resistant to proteolytic degradation. In addition, due to the lack of intramolecular and intermolecular backbone hydrogen bond donors, it is possible to precisely control the peptoid and peptoid-substrate interactions, leading to bio-inspired synthesis of nanomaterials with a layered structure. As a peptide mimic, the peptoids has biocompatibility, non-toxicity and sequence-specific heteropolymers. Nano-peptoids can be synthesized with polar and hydrophobic monomers and have the following advantages: They can be easily processed into desired shapes (e.g. dendritic, sheets, tubes and vesicles), and the size range is 2-100 nm to enhance cell targeting and uptake. The application of nano-peptoids in cell imaging and cancer theranostics will be discussed. Another type of bioinspired nanomaterials with enzyme-like properties is single-atom nanoenzymes. As a biocatalyst, natural enzymes have the ability to accelerate various reaction rates with extremely high activity and selectivity under mild conditions. However, due to the temperature and pH-related denaturation of proteins and the possibility of contamination by bacteria or other reagents, the shelf life of natural enzymes is limited or uncertain, and their purification and production costs are high. Therefore, natural enzymes must narrow the range of conditions under which they can be used, limiting their further applications in biosensing and biomedicine. R Recent research has focused on the rational design of nanomaterials with inherent enzyme-like catalytic properties (for example, oxidase, peroxidase, catalase, superoxide dismutase, and so on) and exploration of their applications in various fields. Although much progress has been made, the development of nanozymes is still hampered by several challenges. Catalytic activity and substrate selectivity are the two most important issues that need to be resolved to allow the technology to reach full maturity. Therefore, rational design and tuning of nanomaterials is highly desirable for the development of novel enzyme-mimic nanomaterials with precise catalytic sites. We have developed various Fe-N-C based single atomic site catalysts which have similar structure with active site of peroxidase. These atomically-dispersed Fe-N-C materials have enzyme-like properties, therefore they are classified as single-atom nanozymes. Together with their abundantly exposed active sites and specific structures, these single atomic nanozymes have great potential for the enhancement of biocatalytic activity and selectivity in biosensing. Jiao, H. Yan, Y. Wu, W. Gu, C. Zhu, D. Du, Y. Lin. When Nanozymes Meet Single-Atom Catalysis. Angew. Chem. Int. Ed. 2020,132, 2585-2596 Zhu, S. Fu, Q. Shi, D. Du, Y. Lin. Single-Atom Electrocatalysts. Angew. Chem. Int. Ed. 2017, 56, 13944-13960. Cheng, J. Li, D. Liu, Y. Lin, D. Du. Single-Atom Nanozyme Based on Nanoengineered Fe-N-C Catalyst with Superior Peroxidase-Like Activity for Ultrasensitive Bioassays. Small, 2019, 1901485. Niu, Q. Shi, W. Zhu, D. Liu, H. Tian, S. Fu, N. Cheng, S. Li, J. N Smith, D. Du, Y. Lin. Unprecedented Peroxidase-mimicking Activity of Single-atom Nanozyme with Atomically Dispersed Fe-Nx Moieties Hosted by MOF Derived Porous Carbon. Biosensors & Bioelectronics, 2019, 142, 111495. Jiao, W. Xu, Y. Wu, H. Yan, W. Gu, D. Du, Y Lin, C. Zhu, Single-atom Catalysts Boost Signal Amplification for Biosensing. Chemical Society Reviews 2021, 50, 750-765 Luo, Y. Song, M. Wang, T. Jian, S. Ding, P. Mu, Z. Liao, Q. Shi, X. Cai, H. Jin, D. Du, W. Dong, C. Chen, Y. Lin. Bioinspired Peptoid Nanotubes for Targeted Tumor Cell Imaging and Chemo-Photodynamic Therapy. Small 2019, 1902485. Song, M. Wang, S. Akkineni, W. Yang, J.J. Hettige, H. Jin, Z. Liao, P. Mu, F. Yan, M. Baer, J. De Yoreo, D. Du, Y. Lin, C. Chen. Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids. ACS Materials Letters 2021, 3, 420-427. Cai, M. Wang, P. Mu, T. Jian, D. Liu, S. Ding, Y. Luo, D. Du, Y. Song, C. Chen, Y. Lin. Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma. Research 2021, Article ID 9861384.

Formation of the redox active insulators such as Lithium peroxide (Li2O2), Lithium sulfide (Li2S) are the salient features for next generation ‘beyond intercalation’ batteries like metal-air (O2) and metal-sulfur (Li-S) batteries (1-3). The interest in these batteries arises from high theoretical energies, abundant elements, low cost, and environmental friendliness. The mechanism to deposit redox active insulators (Li2O2 for Li-O2 and Li2S for Li-S) during discharging these batteries governs their rate capability, capacity, and reversibility. The prime obstacles for rate capability, capacity, and reversibility for Li-O2 batteries are the parasitic reactions. Our previous works discovered that formation of highly active singlet oxygen is the main cause of these parasitic reactions (1, 4-6). On charging Li-O2 battery, the practically achieving high reversible capacities face the challenge to decompose large amounts of insulating Li2O2 while suppressing parasitic reactions. These challenges require understanding the detailed Li2O2 formation mechanism and the interplay between chemistry and morphological evolution. The techniques that we use to decipher the mechanism of the formation of Li2O2 include microscopy and electrochemical generator-collector experiments (hydrodynamic voltammetry and interdigitated electrodes). Previously we illustrated in-situ small and wide-angle X-ray scattering as a novel method to study the morphological evolution in Li-O2 and Li-S batteries (3, 7). The experimental data show that the redox active insulator Li2O2 forms exclusively as particles via solution mediated LiO2 disproportionation during discharging. This contradicts established understanding, stating that the separation between surface adsorbed and solvated LiO2 governs whether Li2O2 grows via a surface mechanism or solution mechanism. We also introduced tools to access complex electrochemical and growth mechanism useful for other systems. This helps us to decipher the mechanism to form and to deposit redox active insulators during charging/discharging of the batteries, and thus to understand the governing factors for capacity, rate capability and reversibility. References: [1] N. Mahne, B. Schafzahl, C. Leypold, M. Leypold, S. Grumm, A. Leitgeb, G.A. Strohmeier, M. Wilkening, O. Fontaine, D. Kramer, C. Slugovc, S.M. Borisov, S.A. Freunberger, Nature Energy, 2, (2017) 17036. [2] D. Cao, X. Shen, A. Wang, F. Yu, Y. Wu, S. Shi, S. A. Freunberger, Y. Chen, Nature Catalysis, 5, (2022) 193–201 [3] C. Prehal, S.D. Talian, A. Vizintin, H. Amenitsch, R. Dominko, S.A. Freunberger, V. Wood, Preprint available at Research Square, (2021) doi: 10.21203/rs.3.rs-818607/v1. [4] N. Mahne, S. E. Renfrew, B. D. McCloskey, S. A. Freunberger, Angew. Chem. Int. Ed. 57 (2018) 5529-5533. [5] E. Mourad, Y.K. Petit, R. Spezia, A. Samojlov, F.F. Summa, C. Prehal, C. Leypold, N. Mahne, C. Slugovc, O. Fontaine, S. Brutti, S.A. Freunberger, Energy Environ. Sci. (2019)., 12 (2019) 2559-2568. [6] Y.K. Petit, E. Mourad, C. Prehal, C. Leypold, A. Windischbacher, D. Mijailovic, C. Slugovc, S.M. Borisov, E. Zojer, S. Brutti, O. Fontaine, S.A. Freunberger, Nature Chem., 13 (2021) 465–471. [7] C. Prehal, A. Samojlov, M. Nachtnebel, L. Lovicar, M. Kriechbaum, H. Amenitsch, S.A. Freunberger, Proc. Natl. Acad. Sci. USA, 118 (2021) e2021893118.

The environmental impact of the use of fossil fuels for energy can be reduced if electricity, which represents one-third of all energy uses, can be generated totally from renewable/sustainable sources such as wind and solar. However, this is only possible if cost-effective long-duration storage technologies are available to allow the highly variable and unpredictable wind and solar energy sources to become reliable baseline energy sources like coal, nuclear or natural gases. Redox flow battery (RFB) energy storage systems are highly suitable for this large-scale, long-duration storage application because while their power output scales with the size of the battery, their energy content resides in the amount of active materials that are stored in external tanks and can be easily scaled up for longer duration.1 The conventional redox flow batteries store electrical energy in the form of some aqueous or non-aqueous soluble ions or compounds in the electrolyte solution. Because of the low solubility (< 2M) of most ions and compounds in aqueous and non-aqueous solvents, these redox flow battery systems have low energy density.2–4 For example, the commercialized all-vanadium RFB system has an average energy density of 20 Wh/kg while that of the lithium-ion battery system is 100-265 Wh/kg.5 To store enough energy for 3-5 days in these RFBs requires a very large volume of solution in a large number of tanks, making these RFB systems expensive due to the cost of tanks and the fluid distribution system and floor space. Our group recently developed a new storage approach that can greatly increase the energy storage density while still enabling the flow battery concept.6 In this approach, the reactants are stored as both soluble ions and their undissolved solid forms and only the liquid containing the soluble ions is circulated through the batteries. This approach potentially enables >4X increase in the storage energy density. This technology was recently demonstrated in a hydrogen-vanadium (VI/V) system, and new test results and findings in this area will be presented in this talk. References H. Zhang, W. Lu, and X. Li, Electrochemical Energy Reviews, 1–15 (2019). D. G. Kwabi et al., Joule, 2, 1894–1906 (2018). M. Wu, T. Zhao, H. Jiang, Y. Zeng, and Y. Ren, Journal of Power Sources, 355, 62–68 (2017). C. Ding, H. Zhang, X. Li, T. Liu, and F. Xing, The Journal of Physical Chemistry Letters, 4, 1281–1294 (2013). A. Manthiram, ACS Central Science, 3, 1063–1069 (2017). Y. Li and T.V. Nguyen, “A Solid-Liquid High-Energy-Density Storage Concept for Redox Flow Batteries and Its Demonstration in an H2-V System,” Paper ID APEN-MIT-2021_023, Applied Energy Symposium: MIT A+B, Aug. 11-13, 2021, Cambridge, MA, USA.

Abstract Chemotherapy has significantly improved the survival of cancer patients. However, the vast variation in treatment responses remains a major issue in the clinic. It is imperative to understand the molecular mechanisms underlying treatment failure in specific populations of patients. Genetic diversity has been recognized to mainly account for the differences in drug responses among patients. Yet, it is not feasible to map the responsible genetic variants within millions of single-nucleotide polymorphisms in the human genome in clinical settings with a limited number of subjects and insufficient genomic information. Genetically diverse mice are an ideal tool to overcome the limitations in clinical studies and model drug responses in hosts that require genetic susceptibility and resistance factors. Recent studies have also implicated a critical role for host cells (i.e., the tissue microenvironment) in building a protective “niche” for tumor cells enabling their escape from chemotherapeutic treatments. Notably, the host regenerative response upon chemotherapy “injury,” which is regarded as an intrinsic host mechanism to repair damaged tissues, may be exploited by tumor cells for their local recurrence or distant metastases. In this study, using a lung injury model, we determined how drug-induced lung stromal wound healing responses differed among eight inbred mouse strains (BALB/cJ, NSG, C57BL/6J, CH3/HeJ, CBA/J, SJL/J, A/J, and NOD/ShiLtJ). Upon either cisplatin or doxorubicin stimulation, the wound healing-associated genes Il-6, Spp1, Cxcl1, and Ccl2 were all found upregulated in lung stromal cells but showed a great variation across different strains. Furthermore, we performed single-cell RNA sequencing on the lung stromal cells and immune cells isolated from three selected mouse strains (BALB/cJ, C57BL/6J, and NOD/ShiLtJ) without and with doxorubicin treatment in vivo. The transcriptomic analyses revealed strain-specific and non-specific therapy-elicited gene signatures in different types of lung tissue cells. Collectively, our results signify an association between genetic backgrounds and drug-induced host responses in mice. The next steps of the study aim to understand how genetic diversity would functionally impact drug-induced lung tissue regeneration, lung inflammation, and post-therapy tumor relapse or metastasis in the lung. Citation Format: Carlos M. Leon, Zheng Gong, Qing Li, Jiayuan Shi, Wulin Zuo, Muneer G. Hasham, Lenny Shultz, Sheng Li, Guangwen Ren. Mouse strain variations in drug-induced lung stromal responses [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1863.

Abstract Modern Chinese Pseudo-Possessive-Object Constructions (shortened as Modern Chinese PPO constructions; e.g. ta shuo le wo de haohua (他说了我的好话) ‘he has put in a good word for me’ and ta chi le wo de doufu (他吃了我的豆腐) ‘he has taken advantage of me’) are actually constructions displaying possessor-affectee syncretism. They derive from Early Modern Chinese Real-Possessive-Object constructions in bridging contexts, some examples being wo ye quande liewei daren de jiu (我也劝得列位大人的酒), ‘I also urged all the magistrates here to finish drinking your wine’ and shi nage zai jie wo de duan li (是那个在揭我的短哩) ‘who is uncovering my demerits’. Di-transitive constructions in Middle Chinese and Early Modern Chinese (e.g. Changxing! quan er yibei jiu (长星，劝尔一杯酒) ‘Comet! I urge you (to finish drinking) a cup of wine’ and shuru gan jie wu duanchu (竖儒敢揭吾短处) ‘how dare the Confucius scholar uncover my demerits’) have provided structural templates for the formation of Modern Chinese PPO constructions. They also have led to a condition in which there are more examples of a maleficiary Modern Chinese PPO construction than examples of a beneficiary Modern Chinese PPO construction (e.g. ta chi le wo de doufu (他吃了我的豆腐) ‘he has taken advantage of me’ vs. ta shuo le wo de haohua (他说了我的好话) ‘he has put in a good word for me’). The grammaticalization pathway can also explain the formation of other constructions including another Modern Chinese PPO construction (e.g. ta chi le wo de kui (他吃了我的亏) ‘he has suffered the loss caused by me’), a Modern Chinese pseudo-object construction (e.g. wo ganxie ni de haoxin (我感谢你的好心) ‘I thank you for your kindness’), and a Modern Chinese pseudo-modifier construction (e.g. wo pa le yi xiawu de shan (我爬了一下午的山) ‘I did mountain-climbing for the whole afternoon’).

Recently, new types of cation disordered rocksalt (DRS) have been reported which show good reversibility. In our study we combined the strategy of using high-valent cations with partial substitution of fluorine for oxygen anions in disordered rocksalt-structure phase to achieve optimal Mn2+/Mn4+ double-redox reaction in the composition system Li2MnxTi1-xO2F (1/3 ≤ x ≤ 1). we synthesized 4 different compositions (Li2MnIIIO2F, Li2MnII 1/3MnIII 1/3TiIV 1/3O2F, Li2MnII 1/2TiIV 1/2O2F and Li2MnII 1/3TiIII 1/3TiIV 1/3O2F). Two of them were synthesized for the first time, Li2MnII 1/3MnIII 1/3TiIV 1/3O2F and Li2Mn II 1/3TiIII 1/3TiIV 1/3O2F. By studying the electrochemical properties of different compounds we found that Ti+4 in the structure keeps Mn at the second state of charge, thus enabling a double redox reaction of Mn2+/Mn4+. By investigating the electrochemical properties of all samples we found that the sample with the composition Li2Mn2/3Ti1/3O2F showed the best electrochemical properties with initial high discharge capacity of 227 mAh g-1 in the voltage window of 1.5-4.3 V and 82% of capacity retentionafter 100 cycles. However, fluorination might lead to several issues such as synthesis limitation, lithium diffusion issues due to preferable strong Li-F bonds, etc. thus, two more different samples based on the Li2Mn2/3Ti1/3O2F composition were synthesized and their properties were investigated (Li1.5MnII 1/3MnIII 1/3TiIV 1/3O2F0.5 and Li1.25MnII 1/3MnIII 1/3TiIV 1/3O2F0.25) in order to find the proper amount of fluorine in the structure which promises the electrochemical behavior. In the following the effect of fluorine on lithium diffusion was investigated by ex-situ Raman studies. These studies shed light on the diffusion pathways of lithium ions during charge and discharge process. The structural characteristics are examined using X-ray diffraction patterns, Rietveld refinement, energy-dispersive X-ray spectroscopy and scanning electron microscopy, transmission electron microscopy and Raman spectroscopy. The oxidation states and charge transfer mechanism are also studied further using extended X-ray absorption fine structure and X-ray photoelectron spectroscopy in which the results approve the double redox mechanism of Mn2+/Mn4+ in agreement with Mn-Ti structural charge compensation. The findings pave the way for designing high capacity electrode materials with multi-electron redox reactions. References: [1]: Chen, R.; Ren, S.; Knapp, M.; Wang, D.; Witter, R.; Fichtner, M.; Hahn, H., Disordered Lithium‐Rich Oxyfluoride as a Stable Host for Enhanced Li+ Intercalation Storage. Advanced Energy Materials 2015, 5, (9), 1401814. [2]: Lee, J.; Kitchaev, D. A.; Kwon, D.-H.; Lee, C.-W.; Papp, J. K.; Liu, Y.-S.; Lun, Z.; Clément, R. J.; Shi, T.; McCloskey, B. D., Reversible Mn 2+/Mn 4+ double redox in lithium-excess cathode materials. Nature 2018, 556, (7700), 185-190.

The radiation conversion phenomenon is used for UV sensing applications with rare earth doped phosphors. This paper presents the results of structural and optical measurements of undoped and europium doped LaPO4 phosphors. LaPO4 phosphors with 1% mol, 2% mol, and 5% mol of europium were fabricated by the co-precipitation method. The effect of Eu3+ concentrations on the luminescence characteristics under UV LED excitation was investigated. The maximum quantum efficiency of luminescence (c.a. 82%) was obtained in sampled doped with 5% of europium. Full Text: PDF ReferencesM. Runowski, "Nanotechnologia – nanomateriały, nanocząstki i wielofunkcyjne nanostruktury typu rdzeń/powłoka", Chemik 68, 9, 766-775 (2014). DirectLink J. Zhou, J.L. Leano Jr., Z. Liu, D. Jin, K.-L. Wong, R.S. Liu, et al., "Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications", Small 14, 1801882 (2018). CrossRef Z. Li, Y. Zhang, G. Han, "Lanthanide-Doped Upconversion Nanoparticles for Imaging-Guided Drug Delivery and Therapy", Springer Series in Biomater. Sci. Eng. 6, 139-164, (2016). CrossRef M. Lin, Y. Zhao, S. Wang, M. Liu, Z. Duan, Y. Chen, et al., "Recent advances in synthesis and surface modification of lanthanide-doped upconversion nanoparticles for biomedical applications", Biotechnol. Adv. 30, 1551-1561 (2012). CrossRef H. Su, Y. Nie, H. Yang, D. Tang, K. Chen, T. Zhang, "Improving the thermal stability of phosphor in a white light-emitting diode (LED) by glass-ceramics: Effect of Al2O3 dopant", J. Eur. Ceram. Soc. 38, 2005-2009 (2018). CrossRef J. Huang, X. Hu, J. Shen, D. Wu, C. Yin, R. Xiang, et al., "Facile synthesis of a thermally stable Ce3+:Y3Al5O12 phosphor-in-glass for white LEDs", Cryst. Eng. Comm 17, 7079-7085 (2015). CrossRef R. Zhang, H. Lin, Y. Yu, D. Chen, J. Xu, Y. Wang, "A new-generation color converter for high-power white LED: transparent Ce3+:YAG phosphor-in-glass", Laser Photon. Rev. 8, 158-164 (2014). CrossRef B. Zheng, Y. Bai, H. Chen, H. Pan, W. Ji, X. Gong, et al., "Near-Infrared Light-Excited Upconverting Persistent Nanophosphors in Vivo for Imaging-Guided Cell Therapy", ACS Appl. Mater. Interfaces 10, 19514 (2018). CrossRef J. Qiao, G. Zhou, Y. Zhou, Q. Zhang, Z. Xia, "Divalent europium-doped near-infrared-emitting phosphor for light-emitting diodes", Nature Communications 10 (1), 5267 (2019). CrossRef V. Singh, A. Kumar, C. Mehare, H. Jeong, S. Dhoble, "UV/VUV excited photoluminescence of Tb3+ doped LaPO4 green emitting phosphors for PDP applications", Optik 206, 163733 (2020). CrossRef G. Han, Y. Wang, C. Wu, J. Zhang, "Hydrothermal synthesis and vacuum ultraviolet-excited luminescence properties of novel Dy3+-doped LaPO4 white light phosphors", Mat. Res. Bull. 44 (12), 2255-2257 (2009). CrossRef K. S. Gupta, P. S. Ghosh, M. Sahu, K. Bhattacharyya, R. Tewari, V. Natarajan, "Intense red emitting monoclinic LaPO4:Eu3+ nanoparticles: host–dopant energy transfer dynamics and photoluminescence properties", RSC Adv. 5, 58832-58842 (2015). CrossRef

The chemical vapour deposition method is widely used to synthesise high quality graphene with a large surface area. However, the cooling process leads to the formations of ripples and wrinkles in the graphene structure. When a self-adhered wrinkle achieves the maximum height, it then folds onto the surface and leads to a collapsed wrinkle. The presence of such deformations often affects the properties of graphene. In this article, we describe a novel mathematical model to understand the formation and geometry of these wrinkles. The stability of these wrinkles is examined based on variational derivations for the energy of each structure. The model provides detailed explanations for the geometry of these wrinkles which would help in tuning their properties. References J. Aljedani, M. J. Chen, and B. J. Cox. Variational model for collapsed graphene wrinkles. Appl. Phys. A 127.11, 886 (2021), pp. 1–13. doi: 10.1007/s00339-021-05000-y A. A. Balandin, S. Ghosh, W. Bao, I. Calizo, D. Teweldebrhan, F. Miao, and C. N. Lau. Superior thermal conductivity of single-layer graphene. Nano Lett. 8.3 (2008), pp. 902–907. doi: 10.1021/nl0731872 S. Chen, Q. Li, Q. Zhang, Y. Qu, H. Ji, R. S. Ruoff, and W. Cai. Thermal conductivity measurements of suspended graphene with and without wrinkles by micro-Raman mapping. Nanotech. 23.36, 365701 (2012). doi: 10.1088/0957-4484/23/36/365701 on p. C85). B. J. Cox, T. Dyer, and N. Thamwattana. A variational model for conformation of graphene wrinkles formed on a shrinking solid metal substrate. Mat. Res. Express 7.8, 085001 (2020). doi: 10.1088/2053-1591/abaa8f A. K. Geim. Graphene: Status and prospects. Science 324.5934 (2009), pp. 1530–1534. doi: 10.1126/science.1158877 on p. C85). K. Kostarelos and K. S. Novoselov. Graphene devices for life. Nature Nanotech. 9 (2014), pp. 744–745. doi: 10.1038/nnano.2014.224 F. Long, P. Yasaei, R. Sanoj, W. Yao, P. Král, A. Salehi-Khojin, and R. Shahbazian-Yassar. Characteristic work function variations of graphene line defects. ACS Appl. Mat. Inter. 8.28 (2016), pp. 18360–18366. doi: 10.1021/acsami.6b04853 R. Muñoz and C. Gómez-Aleixandre. Review of CVD synthesis of graphene. Chem. Vapor Dep. 19.10–12 (2013), pp. 297–322. doi: 10.1002/cvde.201300051 L. Spanu, S. Sorella, and G. Galli. Nature and strength of interlayer binding in graphite. Phys. Rev. Lett. 103.19, 196401 (2009). doi: 10.1103/PhysRevLett.103.196401 T. Verhagen, B. Pacakova, M. Bousa, U. Hübner, M. Kalbac, J. Vejpravova, and O. Frank. Superlattice in collapsed graphene wrinkles. Sci. Rep. 9.1, 9972 (2019). doi: 10.1038/s41598-019-46372-9 C. Wang, Y. Liu, L. Li, and H. Tan. Anisotropic thermal conductivity of graphene wrinkles. Nanoscale 6.11 (2014), pp. 5703–5707. doi: 10.1039/C4NR00423J W. Wang, S. Yang, and A. Wang. Observation of the unexpected morphology of graphene wrinkle on copper substrate. Sci. Rep. 7.1 (2017), pp. 1–6. doi: 10.1038/s41598-017-08159-8 Y. Wang, R. Yang, Z. Shi, L. Zhang, D. Shi, E. Wang, and G. Zhang. Super-elastic graphene ripples for flexible strain sensors. ACS Nano 5.5 (2011), pp. 3645–3650. doi: 10.1021/nn103523t Y. Wei, B. Wang, J. Wu, R. Yang, and M. L. Dunn. Bending rigidity and Gaussian bending stiffness of single-layered graphene. Nano Lett. 13.1 (2013), pp. 26–30. doi: 10.1021/nl303168w Z. Xu and M. J. Buehler. Interface structure and mechanics between graphene and metal substrates: A first-principles study. J. Phys.: Cond. Mat. 22.48, 485301 (2010). doi: 10.1088/0953-8984/22/48/485301 Y. Zhang, N. Wei, J. Zhao, Y. Gong, and T. Rabczuk. Quasi-analytical solution for the stable system of the multi-layer folded graphene wrinkles. J. Appl. Phys. 114.6, 063511 (2013). doi: 10.1063/1.4817768 W. Zhu, T. Low, V. Perebeinos, A. A. Bol, Y. Zhu, H. Yan, J. Tersoff, and P. Avouris. Structure and electronic transport in graphene wrinkles. Nano Lett. 12.7 (2012), pp. 3431–3436. doi: 10.1021/nl300563h

Background:IgG4-related disease (IgG4-RD) is an autoimmune disorder and frequently involve multiple organs. The respiratory tract is one of the most frequently involved sites.Objectives:This study aimed to compare the demographic and clinical characteristics of IgG4-related respiratory disease (IgG4-RRD) and non-IgG4-RRD patients in a large cohort.Methods:We carried out a retrospective study of 452 cases of IgG4-RD (104 IgG4-RRD patients and 348 non-IgG4-RRD patients) diagnosed at Peking University People’s Hospital between 2003 and 2020.Results:IgG4-RRD patients had an elder age of disease onset and diagnosis. Multiorgan involvement and hypocomplementemia were more common in IgG4-RRD. Besides, the level of ESR, eosinophilia, IgG and IgG4 were higher in IgG4-RRD patients. In IgG4-RRD group, salivary gland, lacrimal gland, lymph nodes, biliary system and kidney were more commonly involved than those in the non-IgG4-RRD group. Also, more numbers of organ involvement and biliary involvement were independent risk factors for the development of respiratory involvement in IgG4-RD patients.Conclusion:Our study revealed demographic, clinical, laboratory and imaging features of IgG4-RRD patients and the underlying differences in pathogenesis between the two phenotypes, which have important implications for the diagnosis and treatment of the disease.References:[1]Morales AT, Cignarella AG, Jabeen IS, Barkin JS, Mirsaeidi M. An update on IgG4-related lung disease. European journal of internal medicine. 2019;66:18-24.[2]Stone JH, Zen Y, Deshpande V. IgG4-related disease. The New England journal of medicine. 2012;366(6):539-51.[3]Vasaitis L. IgG4-related disease: A relatively new concept for clinicians. European journal of internal medicine. 2016;27:1-9.[4]Matsui S, Yamamoto H, Minamoto S, Waseda Y, Mishima M, Kubo K. Proposed diagnostic criteria for IgG4-related respiratory disease. Respiratory investigation. 2016;54(2):130-2.[5]Cao L, Chen YB, Zhao DH, Shi WF, Meng S, Xie LX. Pulmonary function tests findings and their diagnostic value in patients with IgG4-related disease. Journal of thoracic disease. 2017;9(3):547-54.[6]Wallace ZS, Perugino C, Matza M, Deshpande V, Sharma A, Stone JH. Immunoglobulin G4-related Disease. Clinics in chest medicine. 2019;40(3):583-97.[7]Matsui S. IgG4-related respiratory disease. Modern rheumatology. 2019;29(2):251-6.[8]Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy. 2001;56(9):813-24.[9]Fei Y, Shi J, Lin W, Chen Y, Feng R, Wu Q, et al. Intrathoracic Involvements of Immunoglobulin G4-Related Sclerosing Disease. Medicine. 2015;94(50):e2150.[10]Wallace ZS, Deshpande V, Mattoo H, Mahajan VS, Kulikova M, Pillai S, et al. IgG4-Related Disease: Clinical and Laboratory Features in One Hundred Twenty-Five Patients. Arthritis & rheumatology (Hoboken, NJ). 2015;67(9):2466-75.[11]Yamada K, Yamamoto M, Saeki T, Mizushima I, Matsui S, Fujisawa Y, et al. New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases. Arthritis research & therapy. 2017;19(1):262.[12]Borges T, Silva S. IgG4-related disease: How to place it in the spectrum of immune-mediated and rheumatologic disorders? Modern rheumatology. 2020;30(4):609-16.[13]Liu Y, Xue M, Wang Z, Zeng Q, Ren L, Zhang Y, et al. Salivary gland involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 428 patients. Rheumatology (Oxford, England). 2020;59(3):634-40.[14]Matsui S, Taki H, Shinoda K, Suzuki K, Hayashi R, Tobe K, et al. Respiratory involvement in IgG4-related Mikulicz’s disease. Modern rheumatology. 2012;22(1):31-9.Disclosure of Interests:None declared

Oxygen dissolving and dissovling capabilities ( briefly, ODC and OCC) are very valuable to assess the functions in oxygen transport and metabolism of red cells, especially for research on, diagnosis, and evaluating therapeutic effects of sick cell disease, thalassemia, and even bone marroe failure. However, the approach to quantify ODC and OCC of red cells is sparse. Mostly, researchers and clicians used oxygen saturation by blood oxymeter to reflect OCC, not right though. ODC and OCC are more resonable to be assessed in extreme situations, e.g., fully deoxy- and oxy- genation. Near infrared spectroscopy (NIRS) [1] has been intensively developed for noninvasive meauring oxygenation changes these years, which utilized the oxy- and dexoy- hemoglobin senstive wavelengths to quantify concentration changes of Hb and HbO2 [2] ( fig.1 ). NIRS is of strong potential in noinavsive assessing blood oxygenation in deep muscle, breast, brain, and tumor [3]. Here we attempt to assess ODC and OCC of red cells to by use of NIRS with aid of a protocol with repeated fully oxy- to deoxy- genation process. Blood samples were got from 8 healthy males and 5 healthy females ( 21.7±2.1 years old ) who were recruited from the university community by physical check-up. No subject had taken any drugs before 3 ml blood sampling. The experiment setup consisted of a tissue like liquid phantom, a NIRS probe [2], a function module and a computer, as shown in Fig.2. The phantom was prepared to simulate blood content and oxygen variation in living human tissue with similar optical property with human tissue, containg 450 ml PBS, 10 ml 10% intralipid solution serving as a scatterer, placed on the plate of a magnetic stirring device to control the solution at 37±1℃. Priorly, 5 g yeast, proved to be more than enough to dioxide the hemoglobin, was spread into the mixture solution. After 20 s of baseline measurement, 0.5 ml human blood was added into the solution to simulate blood content variation. Then, 99.99% oxygen gas, through a container-sized nozzle with dense holes transiting uniform high-pressure 25 MPa oxide, was lead into the solution to fully oxygenate the red cells. Then, the oxygen gas supply was stopped to allow oxygen to be consumed fully by the yeast. The same process, was repeated 6 times. Then, no blood added and repeat above cycle from 100% oxygenation to 100 deoxygenation 35 times. The data of 2 male and 1 female was exluded for solution spilling. The delta optical density ( ∆O.D ) of oxy- and deoxy- sensitive wavelengths were got by NIRS, as shown in Fig. 3 for example, Then we extract the ∆O.Ds at 100% oxygen carrying and 100% oxygen dissolving stages for the final no red cells added 35 process cycles. Among all subjects, the ∆O.Ds curves respond to the repeated 35 cycles of fully oxy- to deoxy- genation at both oxy- and deoxy- sensitive nms formed a first stable then fast drop and then very slow recovery shape. The extracted normalized OCC curves formed higher in in fast drop phase than OCC extracted from above curves. For all subjects, ∆OCC in that phase ranged in 0.62 ± 0.17 while ∆ODC ranged in 0.30 ± 0.10. And there is a positive correlation between ∆OCC and ∆ODC with r = 0.821 and p<0.01. Over all, by use of NIRS with aid of a protocol with enough times ( ≥35 ) repeated fully oxy- to deoxy- genation process, we achieved in assessing both capabilities of red cells in carring and dissolving oxygen ( OCC and ODC ). This novel approach is good to be used to study oxygen function of red cells quantitatively, as well as diagnozing and tracking therapeutic effects of blood diseases. The theory to get why the OCC dropt more than ODC in our protocal is worth of further study, which probabaly allow us to find a path to improve OCC for curing low OCC patients with blood deaseses, such as sick cell disease and thalassemia. And it is worth saying that this study paved a way for NIRS to assess OCC and ODC on patients in noninvase way in near future. [1] F. F. Jöbsis, "Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters," Science, vol. 198, pp. 1264-1267, 1977 [2] Y. Zhao, L. Qiu, Y. Sun, C. Huang, T. Li, Optimal hemoglobin extinction coefficient dataset for near-infrared spectroscopy, Biomed. Opt. Express, vol.8, no.11, pp. 5151-5159, 2017 [3] T. Li, C. Xue, P. Wang, Y. Li, L. Wu, Photon penetration depth in human brain for light monitoring and treatment: A Realistic Monte Carlo Simulation Study, J. Innovative Opt. Health Sci., vol. 10, no. 6, pp. 1743002, 2017 Disclosures No relevant conflicts of interest to declare.

Current standard industrial manufacturing of lithium layered transition metal oxides (LiMO2) as cathode active material (CAM) can be divided into two major process steps: The first step involves coprecipitation of mixed transition metal hydroxide (M(OH)2) particles (M consisting mainly of Ni, Co, and Mn) by mixing a transition metal sulfate solution (MSO4(aq.)) and a sodium hydroxide solution (NaOH(aq.)) in a stirred tank reactor. The resulting hierarchally structured secondary particles are composed of many primary particles which are used as precursors for CAMs (referred to as pCAM). Subsequently, the obtained pCAM is mixed with a lithium source such as Li2CO3 or LiOH and calcined at elevated temperatures to yield LiMO2.1 Recently, reports in the literature have shown clear correlations of CAM morphology with their electrochemical performance in a battery cell.2 Furthermore, it has been demonstrated that the electrochemical performance of a CAM is affected by the morphology of the associated pCAM.3, 4 However, a detailed understanding of the impact of the process parameters on the course of precipitation reaction and on the physical properties of the pCAM precipitate is still lacking. In order to gain a mechanistic understanding of the M(OH)2 pCAM particle formation, ten distinctive Ni0.8Co0.1Mn0.1(OH)2 particle lots were prepared by the coprecipitation method in a stirred tank reactor. The precipitation pH-value was systematically varied between pH = 8.6-12.7, while all other process parameters were kept constant. The S-content of the resulting pCAM powders, representing the residual sulfate (SO4 2-) content, was investigated by S-combustion and is depicted as a function of precipitation pH-value in Figure 1a. In the pH-value range between 8.57 and 10.27 (red), a slight increase in residual SO4 2- from 10.29 mol% to 12.60 mol% is observed until it decreases again to 11.10 mol%. Between pH = 10.27 and pH = 10.74, a sharp transition takes place and residual SO4 2- is reduced by a factor of 4 from 11.10 mol% to 2.60 mol%, which even decreases further with increasing pH-value, namely from 2.60 mol% at pH = 10.74 to 0.35 mol% at pH = 12.69 (green). Interestingly, the turning point in S-content between pH = 10.27 and pH = 10.74 (dashed blue line in Figure 1a) coincides with the point-of-zero-charge (pzc) of Ni(OH)2, which is reported to be at pH = 10.50-10.60.5 This result is rationalized by a pH-dependent SO4 2- adsorption equilibrium that is governing the SO4 2- uptake during the precipitation reaction, as depicted schematically in Figure 1b. For a precipitation below the pzc, positive charged surface hydroxyl-groups of Ni0.8Co0.1Mn0.1(OH)2 attract SO4 2-, resulting in high SO4 2- uptake during M(OH)2 formation and vice versa. In light of these results, it is further demonstrated by x-ray diffraction analysis that SO4 2- adsorption not only governs the crystallinity of the Ni0.8Co0.1Mn0.1(OH)2 material, but also suppresses the vertical crystal growth in the 001-direction during particle formation. This in turn seems to affect the vertical primary particle size as well as the secondary particle porosity, both observable by SEM imaging. The morphological trend is quantitatively verified by extracting the primary particle size distribution from SEM images and by measurements of the secondary particle porosity via nitrogen physisorption. As proof-of-concept for the proposed adsorption mechanism, precipitation reactions at pH = 12.0 with different metal feed sources (MX(aq.), with X = SO4 2-, (NO3 -)2, (CH3COO-)2) were conducted. The resulting clearly distinct physical properties of the Ni0.8Co0.1Mn0.1(OH)2 particles obtained from the different anion systems with different anion adsorption affinities can be well understood based on the Fajans-Paneth-Hahn law for crystallization.6 Finally, desorption experiments indicate options to reduce the residual SO4 2- amount after the Ni0.8Co0.1Mn0.1(OH)2 particle formation has been completed. Based on the results of this study, guidelines for pCAM design are formulated and discussed with respect to composition and subsequent manufacturing steps in industrial CAM production. References: M. H. Lee, Y. J. Kang, S. T. Myung, and Y. K. Sun, Electrochimica Acta, 50 (4), 939-948 (2004). F. Riewald, P. Kurzhals, M. Bianchini, H. Sommer, J. Janek, and H. A. Gasteiger, Journal of The Electrochemical Society, 169 (2), 020529 (2022). Z. Xu, L. Xiao, F. Wang, K. Wu, L. Zhao, M.-R. Li, H.-L. Zhang, Q. Wu, and J. Wang, Journal of Power Sources, 248 180-189 (2014). Y. K. Sun, S. T. Myung, B. C. Park, J. Prakash, I. Belharouak, and K. Amine, Nat Mater, 8 (4), 320-324 (2009). M. Kosmulski, Adv Colloid Interface Sci, 152 (1-2), 14-25 (2009). I. Kolthoff, The Journal of Physical Chemistry, 36 (3), 860-881 (2002). Figure 1

Background:TCZ is a monoclonal antibody against Interleukin-6 receptor (IL-6R) which is used for relieving inflammation and reducing mortality in COVID-19 patients. Safety and efficacy of Tocilizumab (TCZ) in Covid-19 pneumonia is uncertain yet. In this study, we aimed to determine clinical outcomes in patients treated with TCZ.Objectives:In this study we aimed to share our retrospective results which we had obtained from patients with COVID-19 diagnosis received TCZ.Methods:We performed a retrospective case control study between May and August 2020 in Turkey. We compared outcomes in patients who received TCZ with those who did not. Death in hospital and intensive care unit (ICU) requirements were evaluated as endpoints. Demographic data, comorbidities, additional treatment, treatment side effects, laboratory and clinical results were retrospectively assessed. There are no significant differences between groups according to age, gender and Charlson Comorbidity Index (CCI).Results:12 (27.3%) patients died in standard group and eight (18.6%) patients died in TCZ group (p=0.150).Days of staying in the hospital were eight days in standard treatment group and 12 days in TCZ group (p=0.03). 10 of 43 patients in TCZ group were admitted to ICU. MV support was needed in 8 of these patients. 18 of 44 patients (40.9%) within the standard group were admitted to ICU and 12 patients (27.3%) were intubated (p=0.125,p=0.480). Significant IL-6 decrease was not observed post treatment in TCZ group according to pretreatment period (p=0.60). Significant decreases were examined in CRP and ferritin values through TCZ treatment. However, D-dimer and thrombocyte values increased.Conclusion:TCZ may not be an effective treatment for reducing ICU requirement, to prevent intubation or death, for shortening period for staying in hospital. The patients should be followed up closely for possible thrombosis because of increased D-dimer and thrombocytes with TCZ treatment.References:[1]Sharma A, Tiwari S, Deb MK, Marty JL. Severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2): A global pandemic and treatment strategies. IntJ Antimicrob Agents. 2020 Aug; 56(2):106054.[2]Singhal T. A rewiev of coronavirus Disease-2019(COVID-19). Indian J Pediatr. 2020 Apr;87(4):281-286.[3]Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall R.S, Manson J.J. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033-[4]Teijaro J.R. Cytokine storms in infectious diseases. SeminImmunopathol. 2017;39:501–503.[5]Zhang Y, Li J, Zhan Y, Wu L, Yu X, Zhang W et al. Analysis of Serum Cytokines in Patients with Severe Acute Respiratory Syndrome. Infect Immun 2004 Aug;72(8):4410-4415.[6]Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality. Int J Antimicrob Agents. 2020 May; 55(5):105954.[7]Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420–2[8]Fu B, Xu X, Wei H. Why tocilizumab could be an effective treatment for severe COVID-19? J Transl Med 18,164 (2020).[9]Guaraldi G, Meschiari M, Cozzi-Lepri A, Milic J, Tonelli R, Menozzi M et al. Tocilizumab in patients with severe COVID-19: a retrospective cohort study. Lancet Rheumatol. 2020 Aug;2(8):e474-e484.[10]Gupta S, Wang W, Hayek S.S, Chan L, MathewsK.S, Melamed M.L et al. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Intern Med. 2021 Jan1;181(1):41-51.[11]Campochiaro C, Della-Torre E, Cavalli G, De Luca G, Ripa M, Boffini N et al Efficacy and safety of tocilizumab in severe COVID- 19 patients: a single-centre retrospective cohort study. Eur J Intern Med. 2020 Jun;76:43-49.Disclosure of Interests:None declared

The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. 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Novel Coronavirus 2019 (covid-19) is a generation of the coronavirus that humans have never identified. This virus was first reported to cause an outbreak in Wuhan, China, in December 2019. Until now, covid-19 infection cases have been reported in many countries, such as Thailand, Japan, South Korea, Iran, Italy, Germany, and more than 90 countries worldwide. Until November 1, 2020, a total of 412.784 positive cases of covid-19 were recorded, with 341.942 recovered patients and 13.943 deaths in Indonesia. The purpose of this event is to anticipate the spread of Covid-19 by reminding the public to maintain health protocols and other alternatives in preserving health, also increasing body immunity through massage and traditional Indonesian herbal medicine. This event received a good response from the public. It was evidenced by the number of participants exceeding the predetermined quota and enthusiastic in following the speaker's material. The event was a success and was well received by the participants as well as the local government. After following this event, participants can practise the knowledge obtained from the presenters to maintain and protect their health and immunity from Covid-19. Keywords: Covid-19, Community service, body immunity DAFTAR PUSTAKA Amri, Sofan. Iif Khoiru Ahmadi. 2010. Proses Pembelajaran Kreatif dan Inovatif Dalam Kelas: Metode, Landasan Teoritis-Praktis dan Penerapannya. Jakarta: PT. Prestasi Pustakaraya. Badan Pusat Statistik Kota Surabaya. “Jumlah RT RW Kecamatan Dukuh Pakis Menurut Kelurahan Tahun 2017”. surabayakota.bps.go.id. https://surabayakota.bps.go.id/statictable/2018/04/19/594/jumlah-rt-rw-kecamatan-dukuh-pakis-menurut-kelurahan-tahun-2017.html. (diakses 15 Desember 2020). Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z. 2020. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 2020: 395: 497-506. doi: https://doi.org/10.1016/S0140-6736(20)30183-5. Kementerian Kesehatan Republik Indonesia. 2020. Pedoman Kesiapsiagaan Menghadapi Coronavirus Disease (covid-19). Jakarta: Direktorat Jenderal Pencegahan dan Pengendalian Penyakit (P2P). Komite Penanganan Covid-19 dan Pemulihan Ekonomi Nasional. “Pasien Sembuh Harian Mencapai 4.141 Orang”. covid19.go.id. https://covid19.go.id/berita/pasien-sembuh-harian-mencapai-4141-orang. (diakses 15 Desember 2020). Kumar, M., & Dwivedi, S. 2020. “Impact of Coronavirus Imposed Lockdown on Indian Population and their Habits”. International Journal of Science and Healthcare Research Vol.5 Issue: 2: April-June 2020. ISSN: 2455-7587. Li, S., Wang, Y., Xue, J., Zhao, N., & Zhu, T. 2020. “The impact of covid-19 epidemic declaration on psychological consequences: A study on active weibo users”. International Journal of Environmental Research and Public Health, 17(6), 1–9. doi: https://doi.org/10.3390/ijerph17062032. Pemerintah Kota Surabaya, “Statistik”. lawancovid-19.surabaya.go.id. https://lawancovid-19.surabaya.go.id/visualisasi/graph. (diakses 15 Desember 2020). Rizma Riyandi. “Data Kecamatan Surabaya: Dukuh Pakis, Penduduk dan Wilayah”. ayosurabaya.com. https://www.ayosurabaya.com/read/2020/09/28/3230/data-kecamatan-surabaya-dukuh-pakis-penduduk-dan-wilayah. (diakses 15 Desember 2020). Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P. 2020. “A novel coronavirus from patients with pneumonia in China, 2019”. New England Journal of Medicine 2020: 382: 727-733. doi: 10.1056/NEJMoa2001017

Abstract Background: Morpho-physiological alternations of platelets provided a rationale to harness RNA sequencing of tumor-educated platelets (TEPs) for preoperative diagnosis of cancer. Timely, accurate, and non-invasive detection of ovarian cancer in women with adnexal masses presents a significant clinical challenge. Patients and Methods: This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers (China, n=3; Netherlands, n=5; Poland, n=1) between September 2016 and May 2019. The main outcomes were the performance of TEPs and their combination with CA125 in two Chinese (VC1 and VC2) and the European (VC3) validation cohorts collectively and independently. Exploratory outcome was the value of TEPs in public pan-cancer platelet transcriptome datasets. Results: The AUCs for TEPs in the combined validation cohort, VC1, VC2, and VC3 were 0.918 (95% CI 0.889-0.948), 0.923 (0.855-0.990), 0.918 (0.872-0.963), and 0.887 (0.813-0.960), respectively. Combination of TEPs and CA125 demonstrated an AUC of 0.922 (0.889-0.955) in the combined validation cohort; 0.955 (0.912-0.997) in VC1; 0.939 (0.901-0.977) in VC2; 0.917 (0.824-1.000) in VC3. For subgroup analysis, TEPs exhibited an AUC of 0.858, 0.859, and 0.920 to detect early-stage, borderline, non-epithelial diseases and 0.899 to discriminate ovarian cancer from endometriosis. Analysis of public datasets suggested that TEPs had potential to detect multiple malignancies (Table 1). Conclusions: TEPs had robustness, compatibility, and universality for preoperative diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities, heterogeneous histological subtypes, early-stage ovarian cancer as well as other malignancies. However, these observations warrant prospective validations in a larger population before clinical utilities. Table 1. Performance for TEPs in public pan-cancer datasets. Disease n Healthy Control AUC, area under the curve (95% CI) Women NSCLC (non-small-cell lung cancer) 126 77 0.758 (0.691-0.825) Breast cancer 38 77 0.817 (0.726-0.909) Colorectal cancer 18 77 0.973 (0.945-1.000) Pancreatic cancer 16 77 0.993 (0.981-1.000) Glioblastoma 10 77 0.923 (0.831-1.000) Men NSCLC 119 82 0.746 (0.677-0.815) Colorectal cancer 25 82 0.933 (0.884-0.982) Pancreatic cancer 22 82 0.993 (0.984-1.000) Glioblastoma 19 82 0.981 (0.959-1.000) All NSCLC 245 159 0.774 (0.728-0.820) Colorectal cancer 40 159 0.978 (0.961-0.996) Breast cancer 38 159 0.821 (0.736-0.906) Pancreatic cancer 35 159 0.987 (0.974-0.999) Glioblastoma 35 159 0.931 (0.890-0.972) Hepatobiliary carcinomas 14 159 0.991 (0.978-1.000) Citation Format: Yue Gao, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Sjors G.j.g. In ‘t Veld, Gui-Ling Li, Jia-Hao Liu, Guang-Yao Cai, Gui-Yan Xie, Shao-Qing Zeng, Yuan Wu, Jian-Hua Chi, Qiong Zhang, Xiao-Fei Jiao, Lin-Li Shi, Wan-Rong Lu, Wei-Guo Lv, Xing-Sheng Yang, Jurgen M.j. Piek, Cornelis D de Kroon, C.a.r. Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J. Żaczek, Jacek Jassem, Bakhos A. Tannous, Nik Sol, Edward Post, Myron G. Best, Bei-Hua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-Yuan Guo, Qing-Lei Gao. Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB168.