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Journal articles on the topic 'LIC score'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Nacef, L., H. Ferjani, H. Riahi, et al. "AB0191 ON WHICH FACTOR TO ACT TO REDUCE CARDIOVASCULAR RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS?" Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1119.3–1120. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4183.

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Background:Patients with rheumatoid arthritis (RA) are at higher cardiovascular risk (CVR) than the general population due to chronic inflammation. Several factors, both modifiable and non-modifiable, can increase this risk. Intima-media thickness (IMT) was considered as a marker for atherosclerosis.Objectives:This study aimed to identify predictor factors of increasing IMT.Methods:The prospective study was carried out on patients with RA who met the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria. These patients were followed in t

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Vogel, Erika, Jeffrey D. Lebensburger, Shuting Bai, et al. "Liver Histology, Liver Iron Concentration (LIC), and Serum Ferritin in a Large Cohort of Chronically Transfused Children with Sickle Cell Anemia: Limitations of LIC As a Marker for Hepatic Injury and Ferritin as An Indicator for Chelation Initiation." Blood 118, no. 21 (2011): 2142. http://dx.doi.org/10.1182/blood.v118.21.2142.2142.

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Abstract Abstract 2142 Chronic blood transfusion therapy reduces clinical events and prevents recurrent brain injury in children with sickle cell anemia. The benefit of administering chronic transfusion is weighed against the risk of an increased iron burden leading to chronic organ injury. The gold standard technique for evaluating the adverse effect of iron is to perform a liver biopsy for quantification of hepatic iron content and evaluation of liver pathology. Surrogate evaluations for iron overload include monitoring liver enzymes, serum ferritin and performing r2* MRI of the liver. In or

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Cappellini, M. Domenica, Mohamed Bejaoui, Silverio Perrotta, et al. "Correlation of Hepatocyte Iron Score and Liver Iron Ratio with Alanine Aminotransferase in Patients with Beta Thalassemia Receiving Iron Chelation Therapy for at Least 3 Years." Blood 126, no. 23 (2015): 2156. http://dx.doi.org/10.1182/blood.v126.23.2156.2156.

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Abstract Background: Chronic blood transfusions impact the liver due to accumulation of iron, leading to tissue damage, collagen formation and portal fibrosis. Long-term chelation therapy has been shown to be associated with stability or improvement of liver fibrosis and necroinflammation in heavily iron-overloaded patients with β thalassemia, independently of reductions in liver iron concentration (LIC) (Deugnier et al Gastroenterology 2011;141:1202-1211). It was also shown that changes in alanine aminotransferase (ALT, an indicator of hepatocellular damage) mirrored changes in LIC, with sign

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Nacef, L., H. Ferjani, K. Maatallah, et al. "POS0587 EFFECT OF RHEUMATOID ARTHRITIS TREATMENTS ON THE INTIMA-MEDIA THICKNESS OF SUPRA-AORTIC TRUNKS AND ON CARDIOVASCULAR RISK." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 526.2–526. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4120.

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Background:Patients with rheumatoid arthritis (RA) are exposed to a multifactorial cardiovascular risk: chronic inflammation, endogenous and exogenous factors, and treatment.Objectives:The aim of this study was to investigate the impact of RA treatments on cardiovascular risk and the influence of supra aortic trunks.Methods:This is a prospective study conducted on RA patients followed-up between March and December 2020 at the rheumatology department of the Mohamed Kassab Institute of Orthopedics and Traumatology. Socio-demographic data of patients and characteristics of the disease were collec

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Khan, Hammad, Vinodh Panjwani, Sara Al Rahbi, et al. "CORRELATION OF TRANSIENT ELASTOGRAPHY WITH LIVER IRON CONCENTRATION, AND SERUM FERRITIN LEVELS IN PATIENTS WITH TRANSFUSION-DEPENDENT THALASSEMIA MAJOR PATIENTS FROM OMAN." Mediterranean Journal of Hematology and Infectious Diseases 15, no. 1 (2023): e2023048. http://dx.doi.org/10.4084/mjhid.2023.048.

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Aims: In a cross-sectional study we aimed to assess the correlation between ultrasound transient elastography (TE), serum ferritin (SF), liver iron content (LIC) by magnetic resonance imaging (MRI) T2* along with the fibrosis-4 (FIB-4) score as a screening tool to detect significant liver fibrosis among chronically transfusion-dependent beta-thalassemia (TDT) patients.  Methods: The study was conducted at a tertiary health center treating TDT patients. Transient elastography was performed within 3 months of Liver MRI T2* examinations at the radiology department. T-test for independ

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Nacef, L., H. Ferjani, H. Riahi, et al. "AB0186 AT WHAT LEVEL SHOULD WE MEASURE INTIMA-MEDIA THICKNESS IN RHEUMATOID ARTHRITIS?" Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1117.3–1118. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4004.

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Background:Rheumatoid arthritis (RA) is chronic inflammatory rheumatism characterized by an independent cardiovascular (CV) risk. The screening of carotid intima-media thickness (IMT) in the common carotid artery appears to be a marker of atherosclerosis and is used as a specific tool for CV risk assessment.Objectives:The main of this study was to determine the most associated US sites with CV risk in RA.Methods:The present study is a prospective study conducted on Tunisian RA patients in rheumatology department of Mohamed Kassab University Hospital (March and December 2020). The characteristi

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Deugnier, Yves, Bruno Turlin, Victor Dong та ін. "Deferasirox Improves Liver Pathology In β-Thalassemia Patients with Transfusional Iron Overload". Blood 116, № 21 (2010): 4274. http://dx.doi.org/10.1182/blood.v116.21.4274.4274.

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Abstract Abstract 4274 Background: While iron overload is known to cause hepatic toxicity, the effect of iron chelation therapy on liver pathology is not well understood. Data evaluating liver fibrosis during iron chelation therapy are limited to small studies (eg, Wu SF et al. Hemoglobin 2006 [n=17], Berdoukas V et al. Hematol J 2005 [n=49], Wanless IR et al. Blood 2002 [n=56]). In order to address such effects in a more robust patient population, we assessed liver biopsy samples from β-thalassemia patients enrolled in two large clinical studies (Porter J et al. Blood 2005, Cappellini MD et a

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Angelucci, E., B. Turlin, D. Canatan, et al. "Iron Chelation Therapy with Deferasirox (Exjade®, ICL670) or Deferoxamine Is Effective in Reducing Iron Overload in Patients with Advanced Fibrosis and Cirrhosis." Blood 106, no. 11 (2005): 2696. http://dx.doi.org/10.1182/blood.v106.11.2696.2696.

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Abstract Introduction: Although the direct measurement of iron from a liver biopsy is the reference standard method to determine liver iron concentration (LIC), results are highly unreliable in patients with advanced fibrosis and cirrhosis. As a result, chelation therapy is difficult to monitor in this patient population where effective chelation therapy may be critical. It is therefore important to assess parameters additional to LIC in order to accurately assess body iron in these patients. Aim: To analyze the efficacy of chelation with deferoxamine (DFO) and the investigational once-daily,

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Cervantes, Melissa, Ashutosh Lal, Anne M. Marsh, and Ellen B. Fung. "Assessing Bone Quality Using Trabecular Bone Score in Patients with Hemoglobinopathies." Blood 128, no. 22 (2016): 3629. http://dx.doi.org/10.1182/blood.v128.22.3629.3629.

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Abstract Introduction: Osteoporosis is characterized by a decrease in bone mass and density with enlarged trabecular space resulting in porosity and bone fragility. It has been described in as many as 70 to 80% of adults with thalassemia (Thal) and sickle cell disease (SCD). Though assessment by DXA scan is now part of routine clinical practice, bone quality has been poorly characterized, particularly in SCD. Trabecular bone score (TBS) is a new textural analysis of lumbar spine DXA scans that reflects bone microarchitecture, shown to be highly predictive of fracture in adults. The objectives

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Mirault, T., D. Lucidarme, B. Turlin, et al. "Non Invasive Assessment of Hepatic Fibrosis by Measurement of Liver Stiffness in Post Transfusional Iron Overload: Preliminary Results in 15 Patients." Blood 108, no. 11 (2006): 3740. http://dx.doi.org/10.1182/blood.v108.11.3740.3740.

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Abstract Background: The prognosis of liver iron overload is highly dependent on liver iron content (LIC) and the extent of liver fibrosis. Liver biopsy is the invasive reference method for fibrosis evaluation but with several limitations. Non-invasive biological methods (FibroTest, APRI) are not applicable in blood diseases. Transient elastography (TE) is a new non-invasive and rapid bedside method used to measure liver stiffness.This technique has been extensively studied with success in evaluation of liver fibrosis in HCV infection (Ziol, Hepatology 2005; Castera, Gastroenterology 2005). Un

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Elalfy, Mohsen Saleh, and Iman Abdin. "Liver Status in a Cohort of Polytransfused B-Thalassemia Major (BTM) on Long Term Desferrioxamine (DfO) or Deferiprone (L1)." Blood 108, no. 11 (2006): 3732. http://dx.doi.org/10.1182/blood.v108.11.3732.3732.

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Abstract The liver is the main body site for iron storage. Iron chelators as DFo and L1 had problems of compliance and intolerance respectively. This prospective study enrolled 76 BTM patients aged from 9–33 years, mean of 14±4.4 to evaluate the effectiveness of both chelators judged by serum ferritin (sf) and liver iron content (LIC) using repeated liver biopsies. Fifty patients were on DFo 35 mg/kg/day 5 days per week and twenty-six were on L1 75 mg/kg/day on daily bases. Mean baseline sf values were 3678±1922 and 3573±1879 ng/ml while mean baseline LIC was 19.2±7.9 and 18.9±8.1 mg fe/g dw,

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Deugnier, Yves, Bruno Turlin, Martine Ropert, et al. "Semi-Quantitative Assessment of Hemosiderin Distribution Accurately Reflects Reductions in Liver Iron Concentration Following Therapy with Deferasirox (Exjade®, ICL670) or Deferoxamine in Patients with Transfusion-Dependent Anemia." Blood 106, no. 11 (2005): 2708. http://dx.doi.org/10.1182/blood.v106.11.2708.2708.

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Abstract Introduction: Direct biochemical measurement of liver iron from biopsy is the reference standard for determining liver iron concentration (LIC) and therefore the efficacy of chelation therapy. Semi-quantitative assessment of liver iron using Prussian blue stained tissue sections has, however, also been shown to correlate with LIC in patients with non-transfusional hemosiderosis. Aim: To determine the value of semi-quantitative liver iron measurement as an indicator of LIC in patients with transfusion-dependent anemia treated with reference standard therapy deferoxamine (DFO) or the in

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Nacef, L., H. Riahi, Y. Mabrouk, et al. "POS0586 RHEUMATOID ARTHRITIS IS AN INFLAMMATORY DISEASE WITH A HIGH CARDIOVASCULAR RISK." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 526.1–526. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4080.

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Background:Hypertension, diabetes, and dyslipidemia are traditional risk factors of cardiac events. Carotid ultrasonography is an available way to detect subclinical atherosclerosis.Objectives:This study aimed to compare the intima-media thickness in RA patients based on their personal cardiovascular (CV) history of hypertension (hypertension), diabetes, and dyslipidemia.Methods:The present study is a prospective study conducted on Tunisian RA patients in the rheumatology department of Mohamed Kassab University Hospital (March and December 2020). The characteristics of the patients and those o

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Wolfe, Jaime L., Robert Anders, Shirley Reddoch, Kathleen Schwarz, and William Savage. "Longitudinal Analysis of Serial Liver Biopsies in Chronically Transfused Sickle Cell Disease." Blood 118, no. 21 (2011): 1052. http://dx.doi.org/10.1182/blood.v118.21.1052.1052.

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Abstract Abstract 1052 Background: Chronic red cell transfusions are commonly used for the treatment and prevention of complications in sickle cell disease (SCD). Liver injury from transfusional iron overload is a recognized morbidity of chronic transfusion therapy, but little is known about the progression of liver injury over time in SCD. Methods: We conducted a retrospective cohort study of all chronically transfused people with SCD who had 2 or more serial liver biopsies at a single academic hospital. Subjects with viral hepatitis were excluded. Serum ferritin, serum ALT, chelation status,

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Aydinok, Yesim, Amal El-Beshlawy, Claudia von Orelli-Leber, Claudia Czarnecki-Tarabishi, and Chantal Y. Manz. "A Randomized Controlled Trial Comparing the Combination Therapy of Deferiprone (DFP) and Desferrioxamine (DFO) Versus DFP or DFO Monotherapy in Patients with Thalassemia Major." Blood 108, no. 11 (2006): 557. http://dx.doi.org/10.1182/blood.v108.11.557.557.

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Abstract Several clinical studies have shown that the combination of deferiprone (DFP) with desferrioxamine (DFO) is efficacious with regard to decrease in serum ferritin (SF), reduction of liver iron concentration (LIC) and increase in urinary iron excretion (UIE) in patients (pts) suffering from thalassemia major (TM). However, there is lack of randomized controlled trials comparing the efficiacy and safety of the combination therapy versus DFP or DFO monotherapy. This is the first randomized controlled trial analyzing and comparing changes of LIC and total iron excretion (TIE) in pts treate

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Ezzat, Hatoon, John K. Wu, Heather McCartney, and Heather A. Leitch. "Association Between Increased Liver Iron Concentration and Vitamin D Deficiency in Patients with Transfusion Dependent Hemoglobinopathies in British Columbia." Blood 120, no. 21 (2012): 3203. http://dx.doi.org/10.1182/blood.v120.21.3203.3203.

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Abstract Abstract 3203 Background: Patients with transfusion dependent (TD) hemoglobinopathies are at risk of endocrinopathies and bone disease due to iron overload (IOL). Vitamin D is involved in regulation of calcium homeostasis, bone health and other clinical endpoints. Vitamin D deficiency is a common manifestation of patients with transfusional IOL; the mechanism remains unclear. Vitamin D hydroxylation occurs in the liver; whether liver IOL interferes with this step has not to date been addressed. This study investigates an association between liver iron concentration (LIC) and vitamin D

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Allard, Haven M., Marcela G. Weyhmiller, Ashutosh Lal, and Ellen B. Fung. "In-Accuracy Of Bone Density Measurements By DXA In Patients With Hemoglobinopathies and Iron Overload." Blood 122, no. 21 (2013): 966. http://dx.doi.org/10.1182/blood.v122.21.966.966.

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Abstract Introduction When monitoring bone health in patients with hemoglobinapathies, it is unknown if iron in surrounding tissues can lead to inaccuracies in the 2-dimensional assessment by Dual Energy X-ray Absorptiometry (DXA). Objective The aims of this study were: 1) to determine if the accuracy of lumbar spine assessment by DXA is affected by high liver iron concentration in patients with Sickle Cell Disease (SCD) or Thalassemia (Thal), 2) to test the effect of high tissue iron on vertebral Z-scores using phantoms, 3) to explore the ability to account for potential high-iron content eff

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Wood, John C., Leila Noetzli, Ashok Panigrahy, et al. "Changes in Pituitary Iron, Volume, and Function Over Two Years in Pediatric Patients Treated with Deferasirox." Blood 120, no. 21 (2012): 3206. http://dx.doi.org/10.1182/blood.v120.21.3206.3206.

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Abstract Abstract 3206 Introduction: Pituitary iron toxicity remains a critical problem in thalassemia and other transfusional iron overload syndromes because gonadotropic iron deposition occurs early and remains clinically silent until puberty. While MRI screening of heart and liver iron have improved overall survival in these disorders, the heart develops iron overload only after prolonged, unprotected exposure to transfusional iron. We previously demonstrated that overt, clinical hypogonadism is common (83%) in patients having detectable cardiac iron, and is independently associated with pi

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Brissot, P., B. Turlin, G. L. Forni, et al. "Iron Chelation Therapy with Deferasirox (Exjade®, ICL670) or Deferoxamine Results in Reduced Hepatocellular Inflammation and Improved Liver Function in Patients with Transfusion-Dependent Anemia." Blood 106, no. 11 (2005): 823. http://dx.doi.org/10.1182/blood.v106.11.823.823.

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Abstract Transfusional hemosiderosis is often associated with hepatic siderosis or infection with hepatotropic viruses, resulting in hepatocellular injury and progression to chronic liver disease. Liver biopsy is the method of choice for directly assessing damage; scales have been developed to measure necroinflammatory activity (grading) and tissue fibrosis (staging). Iron chelation therapy is historically known to decrease morbidity associated with hepatosiderosis. Aim: To assess 1 year’s chelation therapy with the novel once-daily oral chelator, deferasirox (DSX), or the current standard def

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Shimura-Nukina, Arika, Yosuke Masamoto, Yuki Kagoya, Shunya Arai, and Mineo Kurokawa. "Single-Cell Gene Expression Analysis Identifies Alcam As a Novel Candidate Therapeutic Target in AML." Blood 128, no. 22 (2016): 3915. http://dx.doi.org/10.1182/blood.v128.22.3915.3915.

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Abstract Acute myeloid leukemia (AML) is the most common acute leukemia in adults, characterized by high rate of relapse even in recent days. AML is organized in a hierarchy of heterogeneous cell populations and relapse is generally attributable to chemoresistant leukemia stem cells (LSCs). Anthracyclins and cytarabine, which cannot eliminate LSCs, have remained the mainstay of AML therapy for almost 40 years and novel drugs targeting LSCs more efficiently are urgently needed. Toward that end, a potential strategy is to identify cell surface markers that can be differentially regulated in LSCs

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Kitapondya, N. Deus, Edward Uwezo, Kiremeji Michael, et al. "The Utility of Early Warning Score (EWS) in Predicting Serious Adverse Events Among Patients Presenting to Emergency Departments of Muhimbili National Hospital and MUHAS Academic Medical Center." medtigo Journal of Medicine 2, no. 4 (2024): e30622421. https://doi.org/10.63096/medtigo30622421.

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<strong>Background</strong>: Early Warning Scores (EWS) have been widely studied and applied in high income countries (HIC) for more than a decade, especially in Europe. However, the EWS in low-income countries(LIC’s) such as Tanzania has not been assessed. Given the high acuity and wide range of challenges in management of critically ill patients in the emergency departments (ED) in LIC’s, it is possible that having an EWS would improve patient management and outcomes. <strong>Methods</strong>: A prospective study of adult non-trauma, non-pregnant patients from October 2018 to Jan

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Drasar, Emma, Emer Fitzpatrick, Kate Gardner, et al. "Noninvasive Assessment of Liver Fibrosis in Patients with Sickle Cell Disease." Blood 126, no. 23 (2015): 3406. http://dx.doi.org/10.1182/blood.v126.23.3406.3406.

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Abstract Complications affecting multiple organs, including the liver, contribute to early mortality in patients with sickle cell disease (SCD). Earlier diagnosis and monitoring of "sickle hepatopathy", preferably using non-invasive methods, would enable earlier intervention and therefore, potentially a better outcome for patients. In many non-SCD chronic liver diseases, fibrosis stage is the most important predictor of morbidity and mortality. Two non-invasive methods of assessing liver fibrosis are used: Transient Elastography (TE, Echosens) and Enhanced Liver Fibrosis Score™ (ELF, iQUR). TE

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Mustafa, Nilofar, Qurutulain Mushtaq, Rehana Kanwal, Humaira Tabassum, Qudsia Nawaz, and Samina Rehan Khan. "Frequency of Perinatal Depression in Pregnant Women Utilizing Edinburgh Postnatal Depression Scale." Pakistan Journal of Medical and Health Sciences 17, no. 1 (2023): 533–34. http://dx.doi.org/10.53350/pjmhs2023171533.

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Objective: To determine the frequency of perinatal depression in pregnant women utilizing Edinburgh Postnatal depression scale (EPDS). Study Design: Cross-sectional study Settings: Out-patient Department of Obstetrics and Gynecology, Combined Military hospital, Lahore. Duration of study: 1st November 2018 to 30th April 2019 Total 254 patients were selected. Patients were questioned according to EPDS scale and information recorded on prescribed form. Data was stratified for age, parity, gestational age, education level, and income group. Pregnant women with an EPDS score of ≥9 were considered t

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Yamamoto, Takumi, Nana Yamamoto, Hidehiko Yoshimatsu, Mitsunaga Narushima, and Isao Koshima. "LEC Score." Annals of Plastic Surgery 70, no. 2 (2013): 227–30. http://dx.doi.org/10.1097/sap.0b013e3182380861.

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Gibson, Cameron J., Palmer Q. Bessey, and James Gallagher. "20 The Global Burn Registry: A Work in Progress." Journal of Burn Care & Research 41, Supplement_1 (2020): S16. http://dx.doi.org/10.1093/jbcr/iraa024.024.

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Abstract Introduction In 2018 the World Health Organization (WHO) launched the Global Burn Registry (GBR). Its purpose is to help improve the understanding of burn injury worldwide. The purpose of this study was to identify early findings from this database. Methods The GBR was accessed in September 2019. Cases from centers in low income (LIC) and low-middle income countries (LMIC) were combined into a Low Resource (LR) group, and cases in High Income (HIC) and Upper Middle Income (UMIC) countries were combined into a High Resource group (HR). Statistical analysis was performed with SAS 9.4. D

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Gibson, Cameron, Palmer Q. Bessey, and James J. Gallagher. "The Global Burn Registry: A Work in Progress." Journal of Burn Care & Research 41, no. 5 (2020): 929–34. http://dx.doi.org/10.1093/jbcr/iraa078.

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Abstract In 2018, the World Health Organization (WHO) launched the Global Burn Registry (GBR). Its purpose is to help improve the understanding of burn injury worldwide. The purpose of this study was to identify early findings from this database. The GBR was accessed on January 5, 2020. Cases from centers in low income (LIC) and low-middle-income countries (LMIC) were combined into a low resource (LR) group, and cases in high income (HIC) and upper-middle-income countries (UMIC) were combined into a high resource (HR) group. Statistical analysis was performed with SAS 9.4. Data are expressed a

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Singer, Sylvia T., Jerry Wang, Qing Yuan, et al. "Pituitary Iron and Volume Are Affecting Hormones and Reproductive Potential." Blood 124, no. 21 (2014): 4048. http://dx.doi.org/10.1182/blood.v124.21.4048.4048.

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Abstract Introduction: Hypogonadism and impaired fertility remain critical problems in transfusion dependent thalassemia (TDT) patients who develop iron overload. Pituitary iron toxicity and resultant gland shrinkage were shown to occur in these patients, starting even during their first decade of life. While MRI screening of iron load in the heart has been linked with cardiac function and has a direct effect on iron chelation practices, little is known on pituitary iron and anterior pituitary volume, as they relate to hormone secretion and reproductive potential. We investigated such an assoc

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Kashyap, Richi, Muhammad Ashar Ali, Saad Ullah Malik, et al. "Efficacy and Safety of Amlodipine in Preventing Myocardial Iron Overload in Patients with Transfusion-Dependent Thalassemia Major : A Systematic Review and Meta-Analysis." Blood 136, Supplement 1 (2020): 48–49. http://dx.doi.org/10.1182/blood-2020-137713.

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Background: Patients diagnosed with thalassemia major who are transfusion dependant, have iron accumulation leading to iron toxicity and severe impairment in organs like heart, liver and endocrine organs which are highly sensitive to iron toxicity. This makes iron chelation therapy imperative for these patients. Half of the deaths resulting from iron toxicity related complications are attributed to cardiac complications. Iron chelation therapies have not been completely successful to prevent iron toxicity related complications like arrhythmia, cardiomyopathy and heart failure. Higher doses of

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Ivars, David, Rosa Collado, Carmen Alguero, et al. "Clinical and Biological Characterization of Patients with Low/Intermediate-1 Risk Myelodysplastic Syndrome and Iron Overload." Blood 120, no. 21 (2012): 4956. http://dx.doi.org/10.1182/blood.v120.21.4956.4956.

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Abstract Abstract 4956 Introduction. Patients with Myelodysplastic Syndrome (MDS) are susceptible to developing iron overload as a response to the red blood cell (RBC) transfusions and ineffective hematopoiesis. This iron overload (IOL) is characterized by an increase in oxygen-reactive species accompanied by a decrease in antioxidants, and results in hepatic, cardiac and endocrine disorders, as well as an increased risk of infection. Ineffective hematopoiesis promotes iron absorption at intestinal level. This process is enhanced by the presence of mutations in the hereditary hemochromatosis g

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Amid, Ali, Rebecca Leroux, Manuela Merelles-Pulcini, et al. "Factors Impacting Quality of Life in Thalassemia Patients; Results from the Intercontinenthal Collaborative Study." Blood 128, no. 22 (2016): 3633. http://dx.doi.org/10.1182/blood.v128.22.3633.3633.

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Abstract Thalassemia is one of the most common causes of inherited anemia worldwide. While significant advances has been made in clinical management of thalassemia patients over the past few decades, our knowledge on the factors affecting the quality of life of thalassemia patients is limited. The "IntercontinThal Study" is a collaborative effort to study the quality of life (QoL) and quality of care of thalassemia patients in populations across diverse social and health care systems. Data presented here are from the three participating centers in Canada, Lebanon and Iran. We have gathered stu

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Kwiatkowski, Janet L., Mark C. Walters, Suradej Hongeng та ін. "Long-Term Efficacy and Safety of Betibeglogene Autotemcel Gene Therapy for the Treatment of Transfusion-Dependent β-Thalassemia: Results in Patients with up to 6 Years of Follow-up". Blood 136, Supplement 1 (2020): 51–52. http://dx.doi.org/10.1182/blood-2020-135850.

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Introduction The goal of betibeglogene autotemcel (beti-cel; LentiGlobin for β-thalassemia) gene therapy in patients with transfusion-dependent β-thalassemia (TDT) is lifelong, stable production of functional adult hemoglobin (Hb) sufficient for transfusion independence (TI) and reduction in ineffective erythropoiesis. 60 patients with TDT have been treated with beti-cel across 2 completed phase 1/2 studies (HGB-204, HGB-205) and in 2 ongoing phase 3 studies (HGB-207, HGB-212). After 2-yrs of follow-up in these 4 parent studies, patients were invited to enroll in a 13-yr long-term follow-up st

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Marten, Türk, Busser Luyang, van Dijk Daniël, and J.A. Bosch Max. "[Re] Exploring the Explainability of Bias in Image Captioning Models." ReScience C 9, no. 2 (2023): #21. https://doi.org/10.5281/zenodo.8173703.

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Hutchinson, Angelica, Alexandria Marshall, Fang-Chi Hsu, et al. "EPID-09. QUANTIFYING SOCIAL DETERMINANTS OF HEALTH AMONG GLIOMA PATIENTS." Neuro-Oncology 22, Supplement_2 (2020): ii80. http://dx.doi.org/10.1093/neuonc/noaa215.327.

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Abstract BACKGROUND Social determinants of health (SDH) are modifiable factors that contribute to health outcomes. Despite studies linking SDHs with cervical, ovarian, and prostate cancer outcomes, few studies have explored SDHs in glioma patients. We conducted a cross-sectional survey to characterize and contextualize SDHs in glioma patients by community income, rural/urban residence, and treatment status. METHODS Two validated instruments: PRAPARE (Protocol for responding to and assessing patents’ assets risks and experiences) and AHC (accountable health communities instrument) quantified SD

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Kwizera, Arthur, Jane Nakibuuka, Lydia Nakiyingi, et al. "Acute hypoxaemic respiratory failure in a low-income country: a prospective observational study of hospital prevalence and mortality." BMJ Open Respiratory Research 7, no. 1 (2020): e000719. http://dx.doi.org/10.1136/bmjresp-2020-000719.

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IntroductionLimited data exist on the epidemiology of acute hypoxaemic respiratory failure (AHRF) in low-income countries (LICs). We sought to determine the prevalence of AHRF in critically ill adult patients admitted to a Ugandan tertiary referral hospital; determine clinical and treatment characteristics as well as assess factors associated with mortality.Materials and methodsWe conducted a prospective observational study at the Mulago National Referral and Teaching Hospital in Uganda. Critically ill adults who were hospitalised at the emergency department and met the criteria for AHRF (acut

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Gabriel, Ian H., David Marin, Shahzad Ahmad, et al. "KIR2DS1 Genotype Predicts for Cytogenetic Response, Progression-Free Survival and Overall Survival In Patients with Chronic Phase CML on Imatinib." Blood 116, no. 21 (2010): 888. http://dx.doi.org/10.1182/blood.v116.21.888.888.

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Abstract Abstract 888 Natural killer (NK) cells are expanded in patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitors (TKI) and exert cytotoxicity against CML cells. NK cytotoxicity is determined by the balance between inhibitory and activating signals from cell surface killer immunoglobulin-like receptors (KIRs). The inherited repertoire of KIR genes may therefore influence susceptibility to treatment and prognosis in CML patients treated with TKI. To determine if innate immunity is associated with CML susceptibility and response to TKI, we investigated the impact of KIR

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Perifanis, Vasilios, Efthimia Vlachaki, Emmanouil Sinakos, Ioanna Tsatra, Maria Raptopoulou-Gigi, and Miranda Athanasiou-Metaxa. "Transient Elastography May Predict Liver Iron Overload in Adult Thalassaemia Patients." Blood 112, no. 11 (2008): 5407. http://dx.doi.org/10.1182/blood.v112.11.5407.5407.

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Abstract Although it is life saving, transfusion therapy has resulted in the majority of thalassemia patients being at risk for hemosiderosis-induced organ damage. Liver Iron Concentration (LIC) assessed by liver biopsy is considered the most accurate and sensitive method for determining body iron burden in patients with iron overload. The development of liver fibrosis is more closely related to liver iron concentration. Transient elastography (FibroScan, FS), which measures liver stiffness (LS), is a novel, noninvasive method to assess liver fibrosis. Whether FS is useful in the detection of

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Chapin, John C., Maria Vogiatzi, Dorothy Kleinert, Ersilia DeFilippis, Paul Christos, and Patricia Giardina. "Fracture Prevalence in Adults with Transfusion-Dependent Thalassemia Is Related to Osteoporosis and Age." Blood 124, no. 21 (2014): 4902. http://dx.doi.org/10.1182/blood.v124.21.4902.4902.

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Abstract Introduction: Adults with transfusion dependent thalassemia syndromes are living into later adulthood as a result of better transfusion therapy and chelation. Unfortunately, chronic health problems develop in these patients that persist into adulthood. Osteoporosis and osteopenia are significant co-morbidities in the thalassemia population as a result of impaired growth in childhood, extramedullary expansion of the marrow, iron deposition, vitamin D deficiencies, and hypogonadism. The morbidity of osteoporosis is significant in this population, leading to fractures and chronic pain. T

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Maestripieri, Dario. "Litter Gender Composition, Food Availability, and Maternal Defence of the Young in House Mice (Mus Domesticus)." Behaviour 116, no. 3-4 (1991): 239–50. http://dx.doi.org/10.1163/156853991x00058.

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AbstractLitter gender composition (LGC) of 33 litters of outbred Swiss albino mice was manipulated at birth to obtain 100%-male litters (MM), 50%-male litters (MF) and 100%-female litters (FF). Litter size was 10 in all cases. Litter defence by their respective dams (5-min exposure to an unfamiliar adult male) was scored on postpartum day 7. The influence of litter gender composition on the female's litter defence was tested, with identical procedure, under conditions of restricted feeding. In this case, dams were fed from postpartum days 1-7 with 80% of their normal daily requirement. Under b

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Kitagawa, Yoshiyasu, Takuto Suzuki, Taro Hara, et al. "Linked color imaging improves the endoscopic visibility of gastric mucosal cancers." Endoscopy International Open 07, no. 02 (2019): E164—E170. http://dx.doi.org/10.1055/a-0733-7086.

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Abstract Background and study aims As a newly developed endoscopy technique, linked color imaging (LCI) provides very bright images with enhanced color tones. With the objective of improving the detection rate of gastric mucosal cancers, which are often difficult to detect, we examined the utility of LCI from the viewpoint of visibility. Patients and methods The current study used 100 consecutive gastric mucosal cancers ≤ 20 mm in diameter. For each lesion, we selected one endoscopic image acquired by white-light imaging (WLI), blue-laser imaging (BLI) -bright, and LCI modes. Four endoscopists

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Monlezun, Dominique J., Oleg Sinyavskiy, Nathaniel Peters, et al. "Artificial Intelligence-Augmented Propensity Score, Cost Effectiveness and Computational Ethical Analysis of Cardiac Arrest and Active Cancer with Novel Mortality Predictive Score." Medicina 58, no. 8 (2022): 1039. http://dx.doi.org/10.3390/medicina58081039.

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Background and objectives: Little is known about outcome improvements and disparities in cardiac arrest and active cancer. We performed the first known AI and propensity score (PS)-augmented clinical, cost-effectiveness, and computational ethical analysis of cardio-oncology cardiac arrests including left heart catheterization (LHC)-related mortality reduction and related disparities. Materials and methods: A nationally representative cohort analysis was performed for mortality and cost by active cancer using the largest United States all-payer inpatient dataset, the National Inpatient Sample,

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Kanojiya, Rajkamal, Rekha Chaudhary, Rishi Deep Jain, and Esha Patel. "Comparison of Pain Score in Open Hemorrhoidectomy with and without (Lateral Internal Sphincterotomy) LIS." International Journal of Science and Research (IJSR) 12, no. 12 (2023): 45–46. http://dx.doi.org/10.21275/sr231130182420.

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Lutterkort, Gunnar L., Anika Wranke, Cihan Yurdaydin, et al. "Non-invasive fibrosis score for hepatitis delta." Liver International 37, no. 2 (2016): 196–204. http://dx.doi.org/10.1111/liv.13205.

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Rostoker, Guy, Mireille Laroudie, Raphaël Blanc, et al. "Histological Scores Validate the Accuracy of Hepatic Iron Load Measured by Signal Intensity Ratio and R2* Relaxometry MRI in Dialysis Patients." Journal of Clinical Medicine 9, no. 1 (2019): 17. http://dx.doi.org/10.3390/jcm9010017.

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Almost all haemodialysis patients are treated with parenteral iron to compensate for blood loss and to allow the full therapeutic effect of erythropoiesis-stimulating agents. Iron overload is an increasingly recognised clinical situation diagnosed by quantitative magnetic resonance imaging (MRI). MRI methods have not been fully validated in dialysis patients. We compared Deugnier’s and Turlin’s histological scoring of iron overload and Scheuer’s classification (with Perls’ stain) with three quantitative MRI methods for measuring liver iron concentration (LIC)—signal intensity ratio (SIR), R2*

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Takagi, T., K. Uchiyama, M. Kajiwara, et al. "P310 The efficacy of linked colour imaging, a novel endoscopic enhancement system, for diagnosing mucosal redness in ulcerative colitis patients in clinical remission." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S309. http://dx.doi.org/10.1093/ecco-jcc/jjz203.439.

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Abstract Background Endoscopic mucosal healing is considered as an important therapeutic goal in ulcerative colitis (UC) patients, and several endoscopic evaluations for colonic mucosa such as Mayo endoscopic subscore (MES) and Colitis Endoscopic Index of Severity (UCEIS) are used in clinical practice. Though the strict mucosal healing is defined as MES 0, the relapse of UC has been shown in the patients diagnosed as MES 0. In the present study, we aimed to investigate the efficacy of Linked Color Imaging (LCI), a novel endoscopic enhancement system, to predict long-term prognosis in UC patien

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Verstraete, Jean-Christophe. "Preverbal positions in three Germanic languages." Languages in Contrast 4, no. 1 (2004): 105–36. http://dx.doi.org/10.1075/lic.4.1.06ver.

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This study investigates the opposition between intra-clausal and extra-clausal positions in the preverbal domain in English, German and Dutch. It is argued that some of the traditional criteria used to distinguish between these positions, especially the criterion of pronominal resumption, are not entirely reliable, and a number of new criteria are introduced, including distribution in non-declarative contexts. On the basis of these descriptive refinements, it is proposed that the opposition between intra-clausal and extra-clausal positions can be defined functionally in terms of the scope of i

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Guo, Qiang, Xiao-Li Liu, Hua-Song Liu, et al. "The Risk Model Based on the Three Oxidative Stress-Related Genes Evaluates the Prognosis of LAC Patients." Oxidative Medicine and Cellular Longevity 2022 (June 23, 2022): 1–19. http://dx.doi.org/10.1155/2022/4022896.

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Background. Oxidative stress plays a role in carcinogenesis. This study explores the roles of oxidative stress-related genes (OSRGs) in lung adenocarcinoma (LAC). Besides, we construct a risk score model of OSRGs that evaluates the prognosis of LAC patients. Methods. OSRGs were downloaded from the Gene Set Enrichment Analysis (GSEA) website. The expression levels of OSRGs were confirmed in LAC tissues of the TCGA database. GO and KEGG analyses were used to evaluate the roles and mechanisms of oxidative stress-related differentially expressed genes (DEGs). Survival, ROC, Cox analysis, and AIC m

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Casagranda, Sara, Maria Chiara Magri, Stefania Galimberti, et al. "Iron Overload after Hematopoietic Stem Cell Transplantation." Blood 132, Supplement 1 (2018): 4599. http://dx.doi.org/10.1182/blood-2018-99-114911.

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Abstract Introduction Iron overload (IOL) is a common complication after HSCT, mainly due to iterative red blood cell (RBC) transfusions with other mechanisms as ineffective erythropoiesis or dysregulation of hepcidin possibly contributing. IOL prevalence is estimated as 30-60% in adults transplanted for hematological malignancies, but few data are available in pediatric malignancies. Patients and Methods All patients (pts) undergoing allogenic HSCT between January 2012 and December 2016 in our institution, who were alive and in continuous complete remission at the last follow-up were included

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Thompson, Alexis, Janet L. Kwiatkowski, Jennifer Schneiderman та ін. "Betibeglogene Autotemcel (beti-cel) Gene Addition Therapy Results in Durable Hemoglobin a Production with up to 10 Years of Follow-up with Transfusion-Dependent β-Thalassemia". Blood 144, Supplement 1 (2024): 2194. https://doi.org/10.1182/blood-2024-200152.

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Drs. Thompson and Kwiatkowski contributed equally. Introduction: Beti-cel gene therapy is a one-time treatment for transfusion-dependent β-thalassemia (TDT) that adds functional copies of the β-globin gene (βT87Q) to address the underlying cause of disease. Here, we report long-term outcomes of participants treated with beti-cel with up to 10 years of follow-up. Methods: After completion of a 2-year phase 1/2 (HGB-204 [NCT01745120]; HGB-205 [NCT02151526]) or phase 3 (HGB-207 [NCT02906202]; HGB-212 [NCT03207009]) beti-cel parent study, treated participants were eligible for the long-term, 13-ye

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Sertoglu, Erdim, Huseyin Kayadibi, and Metin Uyanik. "Interfering parameters in nonalcoholic fatty liver disease fibrosis score." Liver International 35, no. 1 (2014): 285. http://dx.doi.org/10.1111/liv.12650.

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Oh, Stephen T., Moshe Talpaz, Aaron T. Gerds, et al. "Hepcidin Suppression By Momelotinib Is Associated with Increased Iron Availability and Erythropoiesis in Transfusion-Dependent Myelofibrosis Patients." Blood 132, Supplement 1 (2018): 4282. http://dx.doi.org/10.1182/blood-2018-99-111349.

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Abstract Introduction: Patients develop anemia as a result of myelofibrosis (MF) or its treatment, including Janus kinase (JAK) inhibitors. However, momelotinib (MMB), a JAK1/2 and Activin A receptor type I (ACVR1) inhibitor with demonstrated clinical activity in MF, improved anemia in prior clinical trials. JAK1/2 and ACVR1 respond to inflammation and iron stores to control iron availability through hepcidin, the key regulator of the entry of iron into circulation. Like other inflammatory diseases, MF is characterized by high hepcidin. MMB inhibited ACVR1 to modulate hepcidin and ameliorate a

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