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Relevant bibliographies by topics / Life sciences. Influenza Immune response / Dissertations / Theses

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Dissertations / Theses on the topic 'Life sciences. Influenza Immune response'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Ritz, Barry W. Gardner Elizabeth M. "Nutritional modulation of the innate immune response to influenza infection /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1787.

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2

Wu, Cheng Ying. "Characterization of innate immune response to «Nicotiana benthamiana»-derived Influenza H5 virus-like particles." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119400.

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Current influenza vaccine manufacturing processes using chicken-embryonated egg technology is a time-consuming and laborious process, and is currently the major drawback in counteracting pandemic influenza strain. One solution to that problem is the use of plants to generate vaccine antigen. Virus-like particles (VLP), produced from the tobacco plant Nicotiana benthamiana, represent a cost-effective, alternative platform for influenza vaccine production. Previous studies have shown that the immunization with VLP expressing the hemagglutinin (HA) protein from influenza virus H5N1 (H5-VLP) produ

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3

Maj, El sharif. "Early life stress and its association with epigenetics and immune system response." Thesis, Linköpings universitet, Biologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138947.

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Stress can induce prolonged deleterious effects on many characteristics in chickens (Gallus gallus). Particular interest has been paid to early life stress. Social isolation as an early life stressor results in increased plasma corticosterone levels. Moreover, it induces behavioural and physiological changes as well as gene expression modifications in the hypothalamus. In the first part of my study, I aim to inquire into social isolation impacts on the short and long-term. Short and long-term effects were assessed by immune system, behaviour and weight. 82 male chickens were assigned to three

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4

Gailor, Russell. "The Relationship Between the Murine Primary Immune Response to Sheep Red Blood Cells & Heterosis." TopSCHOLAR®, 1989. https://digitalcommons.wku.edu/theses/2373.

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Two inbred strains of mice, BALB/c and C57BL, were crossbred to produce Fl hybrids. This breeding scheme ensured a high degree of genetic heterozygosity as exemplified by the fact that the average weight of the Fl hybrids at 10 weeks of age was 10.1 percent greater that that of their contemporaries in the inbred parental strains. The three lines of mice were then challenged with a 0.5 ml intraperitoneal injection of two-percent sheep red blood cells (SRBC). After a 15-day period the mice were bled and their sera were microtitrated for anti-SRBC agglutinin and the titers statistically analyzed.

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5

Hunzeker, John T. "Differential effects of stress on the immune response to influenza A/PR8 virus infection in mice." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1080588837.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvi, 231 p.; also includes graphics Includes bibliographical references (p. 211-231). Available online via OhioLINK's ETD Center

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6

Palmer, Duncan. "Selection along the HIV-1 genome through the CTL mediated immune response." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:1cd57b15-485d-4f5a-8a1c-7702a355c597.

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During human immunodeficiency virus 1 (HIV-1) infection, the viral population is in constant battle with the host immune system. The cytotoxic T-lymphocyte (CTL) response, a branch of the adaptive immune response, is implicated in viral control and can drive viral evolution in the infected host population. Endogenous viral peptides, or ‘epitopes’, are presented to CTLs by human leukocyte antigen (HLA) class I molecules on the surface of infected cells where they may be identified as non-self. Mutations in or proximal to a viral epitope can result in ‘escape’ from CTLs targeting that epitope. T

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7

Tomkinson, Blake E. "The Cellular Immune Response to Epstein-Barr Virus during Active Infectious Mononucleosis: a Thesis." eScholarship@UMMS, 1988. http://escholarship.umassmed.edu/gsbs_diss/292.

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Epstein-Barr virus (EBV) induced infectious mononucleosis (IM) is characterized by the activation and expansion of T lymphocytes and the induction of cytotoxic responses able to mediate the lysis of EBV-uninfected, allogeneic MHC mismatched and EBV-infected autologous target cells. Freshly isolated peripheral blood mononuclear cells (PBMC) were used to examine the nature of these cellular immune responses. Activated lymphocytes, as identified by HLA-DR expression, associated with EBV induced IM were shown to be a heterogeneous population containing significantly elevated cytotoxic/suppress

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8

Boyle, Christine Margaret. "DNA Immunization: Basic Mechanisms of the DNA-Raised Antibody Response Using an Influenza Hemagglutinin-Expressing Plasmid: A Dissertation." eScholarship@UMMS, 2000. https://escholarship.umassmed.edu/gsbs_diss/151.

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In DNA immunization a plasmid expressing an antigen of interest is inoculated into an animal and antigen-specific humoral and cellular immune responses are raised. In this dissertation we sought to further our understanding of antibody responses raised following DNA inoculation. Specifically, we examined the role of lymphoid tissue in the initiation and maintenance of the long-term antibody response, the role of CD4+ and CD8+ T cells in the DNA-raised antibody response, the longevity of functional antigen expression, and the nature of the antigen presenting cell. In all of these studies mice w

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Boyle, Christine Margaret. "DNA Immunization: Basic Mechanisms of the DNA-Raised Antibody Response Using an Influenza Hemagglutinin-Expressing Plasmid: A Dissertation." eScholarship@UMMS, 2003. http://escholarship.umassmed.edu/gsbs_diss/151.

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In DNA immunization a plasmid expressing an antigen of interest is inoculated into an animal and antigen-specific humoral and cellular immune responses are raised. In this dissertation we sought to further our understanding of antibody responses raised following DNA inoculation. Specifically, we examined the role of lymphoid tissue in the initiation and maintenance of the long-term antibody response, the role of CD4+ and CD8+ T cells in the DNA-raised antibody response, the longevity of functional antigen expression, and the nature of the antigen presenting cell. In all of these studies mice w

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10

Acquah, Phyllis V. "Inhibition of Margination and Diapedesis of Neutrophils by Protein Synthesis Blockade." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1439.

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Acute Respiratory Distress Syndrome (ARDS), an age-old clinical problem facing the Emergency Department and Intensive Care Units of all health systems, is a common debilitating lung condition consequent upon severe systemic inflammation. Although several studies have gone into understanding the epidemiology and pathogenesis of the disease thus making way for new advances in treatment strategies, there seems to be no known study tailored to its prevention. Neutrophil extravasation within the tissues during inflammation is the hallmark of this syndrome. Our study sought to block excessive neutro

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11

Azevedo, Marcela. "Engineering of Lactic Acid Bacteria strains modulating immune response for vaccination and delivery of therapeutics." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00981946.

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The use of Lactic Acid Bacteria (LAB), such as Lactococcus lactis (LL), as DNA delivery vehicles represents an interesting strategy as they are regarded as safe. Wild type (wt) LL or recombinant invasive LL, were able to trigger DNA expression by epithelial cells both in vitro and in vivo. However, important information about how LL can transfer DNA plasmids is still missing. Therefore, we decided to construct a new recombinant invasive LL strain expressing mutated Internalin A (mInlA) from the pathogen Listeria monocytogenes to understand the manner by which the DNA is transferred to mammalia

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12

Ma, Yuting. "The crosstalk between dying tumor cells and immune effectors within tumor microenvironment elicited by anti-cancer therapies dictates the therapeutic outcome." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00636891.

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Besides exerting cytostatic or cytotoxic effects on tumor cells, some anti-cancer therapies (anthracyclines, oxaliplatin, X-Rays) could trigger an immunogenic cell death modality, releasing danger signals to alert immune system. We have shown that tumor-specific IFN- producing CD8+ T cells (Tc1) are mandatory for the success of chemotherapy to prevent tumor outgrowth. Priming of Tc1 response depends on IL-1β secretion by DC confronted with anthracycline-treated tumor cells releasing ATP. To identify the inflammatory components which link innate and cognate immune responses, we analyzed the in

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13

Ganesh, Bhanu Priya. "Host-microbe interactions in the inflamed gut." Phd thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2014/6955/.

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Initiation and perpetuation of inflammatory bowel diseases (IBD) may result from an exaggerated mucosal immune response to the luminal microbiota in a susceptible host. We proposed that this may be caused either 1) by an abnormal microbial composition or 2) by weakening of the protective mucus layer due to excessive mucus degradation, which may lead to an easy access of luminal antigens to the host mucosa triggering inflammation. We tested whether the probiotic Enterococcus faecium NCIMB 10415 (NCIMB) is capable of reducing chronic gut inflammation by changing the existing gut microbiota comp

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14

Barrientos, Lorena. "Modulation fonctionnelle des cellules dendritiques par les " Neutrophil Extracellular Traps "." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-01016696.

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Les polynucléaires neutrophiles (PN) sont des cellules essentielles au cours de la réponse immunitaire innée ; recrutés rapidement au site inflammatoire où ils participent à la phase aigüe, ils vont aussi contribuer à la résolution de l'inflammation. Ils peuvent en effet moduler la réponse adaptative par interaction avec les lymphocytes (Ly) ou les cellules dendritiques (DC) via des médiateurs solubles ou des interactions cellulaires directes. Les Neutrophil Extracellular Traps (NETs) libérés par les PN activés pourraient jouer un rôle important dans ce contexte. Les NETs sont des filaments de

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15

Brown, Josephine Michelle. "Characterization of the interaction between Basigin and the pattern recognition receptor TLR4." UNF Digital Commons, 2016. http://digitalcommons.unf.edu/etd/650.

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Toll-like receptors (TLRs) are a major group of pattern recognition receptors expressed on the surface of immune cells that recognize molecular patterns associated with all classes of pathogenic microorganisms. TLR4 recognizes the lipopolysaccharide component of Gram-negative bacterial cell walls and is the only TLR known to induce signaling through both the MyD88 and TRIF pathways. Basigin, a ubiquitous cell adhesion molecule, is a member of the immunoglobulin superfamily that has the ability to influence cell signaling mediated by the MyD88 and TRIF pathways, the same signaling pathways indu

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16

Terry, Emmanuelle. "Modélisation mathématique des dynamiques de la réponse immunitaire T CD8, aux échelles cellulaire et moléculaire." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00763897.

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La réponse immunitaire se produit en réaction à une infection, c'est- à-dire à l'introduction d'un pathogène dans l'organisme. Nous nous intéressons à une population de cellules spécifique de la réponse, les lymphocytes T CD8. Nous avons développé un modèle non linéaire structuré en âge des dynamiques de cette réponse, à l' échelle cellulaire. Nous avons étudié l'existence et la stabilité des états d' équilibre, et obtenu des propriétés mettant en évidence, sous certaines conditions, des dynamiques à long terme correspondant à la situation biologiquement attendue. Nous avons ensuite réalisé un

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17

Audia, Sylvain. "Etude physiopathologique de la réponse immunitaire au cours de la thrombopénie immunologique (purpura thrombopénique immunologique)." Phd thesis, Université de Bourgogne, 2010. http://tel.archives-ouvertes.fr/tel-00687984.

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La thrombopénie immunologique ou purpura thrombopénique immunologique (PTI) est une maladie auto-immune rare responsable d'une destruction périphérique immunologique des plaquettes associée à une production médullaire inadaptée. Dans la première partie de ce travail, nous exposons les connaissances actuelles de sa physiopathologie ainsi que certaines données concernant la réponse immunitaire T, le rôle des lymphocytes T régulateurs (Treg), l'implication de la rate dans la réponse immunitaire ainsi que les modes d'action d'une thérapeutique anti-lymphocytaire B, le rituximab. Dans une seconde p

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18

Binias, Cindy. "Epizootiologie et contribution à la caractérisation de l'agent infectieux de la maladie du muscle marron, une pathologie émergente de la palourde japonaise, Venerupis philippinarum." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2013. http://tel.archives-ouvertes.fr/tel-00949926.

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Seconde espèce de mollusque bivalve la plus exploitée au monde, la palourde japonaise Venerupis philippinarum représente un intérêt économique majeur. A l'échelle du bassin d'Arcachon, la maladie du muscle marron ou BMD (pour Brown Muscle Disease), pathologie émergente découverte en 2005 inquiète tout particulièrement le secteur de la pêche. Cette pathologie affecte le muscle adducteur postérieur de la palourde et perturbe l'ouverture-fermeture des valves. Cette perturbation entraine la remontée des individus à la surface du sédiment et la mort.Ces travaux de thèse ont porté d'une part sur l'é

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19

Galmès, Johanna. "Isolement et caractérisation de nouvelles espèces de Torque Teno Mini Virus (TTMV) : implication potentielle dans la pathogenèse de la pneumonie." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2013. http://tel.archives-ouvertes.fr/tel-00923721.

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La pneumonie est la première cause de mortalité chez l'enfant dans le monde. Elle peut être provoquée par un certain nombre d'agents pathogènes connus mais 15 à 35% des pneumonies de l'enfant restent encore non renseignées d'un point de vue étiologique. L'utilisation d'un test moléculaire de découverte de nouveaux pathogènes nous a permis de découvrir de nouvelles espèces de Torque Teno Mini Virus (TTMV, Anelloviridae), nommées TTMV-LY, dans trois épanchements pleuraux provenant d'enfants hospitalisés avec une pleuro-pneumopathie, dont l'étiologie demeurait inconnue. Les TTMV sont des virus ub

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20

Russier, Marion. "Cellules NK et fièvres hémorragiques virales : étude de leur rôle dans la mise en place des réponses immunes et dans la pathogenèse lors de l'infection par les virus Lassa et Ebola." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2013. http://tel.archives-ouvertes.fr/tel-00835079.

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Les fièvres hémorragiques à virus Lassa (LASV) et Ebola (EBOV) représentent un important problème de santé publique en Afrique. Les réponses immunes et la pathogenèse associées à ces maladies sont peu connues. Les cellules NK ont un rôle important dans la réponse immune innée par leurs propriétés cytotoxiques, mais également dans l'induction des réponses adaptatives par leur production de cytokines et leurs interactions avec les cellules dendritiques (DC) et les macrophages. Ce projet s'attache à comprendre le rôle des cellules NK dans le contrôle de la réplication virale et dans l'induction d

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21

Doucet, Jean-Daniel. "Réponse cellulaire pan-spécifique : analyse de la présentation d’antigènes conservés du virus de l’influenza." Thèse, 2010. http://hdl.handle.net/1866/4928.

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Les méthodes de vaccination actuelles contre l’influenza, axées sur la réponse à anticorps dirigée contre des antigènes hautement variables, nécessitent la production d’un vaccin pour chaque nouvelle souche. Le défi est maintenant de stimuler simultanément une réponse cellulaire pan-spécifique ciblant des antigènes conservés du virus, tel que la protéine de la matrice (M1) ou la nucléoprotéine (NP). Or, la présentation antigénique de ces protéines est peu définie chez l’humain. Nous avons analysé la présentation endogène par les complexes majeurs d’histocompatibilité de classes (CMH)-I et -II

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