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Dissertations / Theses on the topic 'Ligand systems'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Freundlich, Joel Stephen. "Metal-ligand multiple bonds in organometallic complexes containing triamidoamine ligand systems." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/38782.

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2

Taylor, Steven John. "Exploratory studies of novel ligand systems." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1004973.

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A range of novel ligand systems have been developed in three distinct phases and preliminary studies have been initiated to evaluate their complexation potential. Phase I incorporated the synthesis of single strand ligand systems, which were mainly based on amino acid residues. Techniques have been developed for the attachment of these ligand systems onto, firstly, a styrene monomer, and then later onto a pseudo-styrene linking group, viz. the p-toluoyl group. The linking reactions were based on the formation of amides or esters by the reaction of an acid chloride system with an amine or alcoh

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3

Kidd, Sara Jean. "Studies of group 15/nitrogen ligand systems." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621394.

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4

Mitra, Amritaa. "Multidentate ligand systems: metal binding and applications." Thesis, University of North Bengal, 2017. http://ir.nbu.ac.in/handle/123456789/2627.

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5

Paul, Diana Rachel. "The development of new organolead reagents in organic synthesis." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320635.

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6

Bujotzek, Alexander [Verfasser]. "Molecular Simulation of Multivalent Ligand-Receptor Systems / Alexander Bujotzek." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1041255721/34.

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7

Peace, Richard John. "Bulky ligand systems containing pi-acidic aryl and carboranyl groups." Thesis, Durham University, 1996. http://etheses.dur.ac.uk/5388/.

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This thesis describes studies into the synthesis and coordination chemistry of ligands containing bulky π-acidic groups. Both π-acidic aryl and carboranyl groups have been investigated. Chapter One highlights electronic and structural aspects of ligands investigated and computational techniques employed. Chapter Two describes the synthesis of aromatic systems bearing nitrogen substituents and trifluoromethyl groups, with a view to their use in the synthesis of new ligands. The π -interaction between the nitrogen substituent and aromatic ring has been investigated and is found to vary considera

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8

Li, Aixiao. "Molecular modeling of non-bonding interactions in biomolecules-ligand systems." Paris 7, 2009. http://www.theses.fr/2009PA077032.

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Ce travail est consacré à la modélisation des interactions entre des inhibiteurs et des molécules impliquées dans la cancérisation, dans le but notamment d'établir de manière précise les modes d'interaction biomolécules-ligand. Dans la famille des CDK (cyclin dépendant kinases) nous nous sommes intéressés à la sélectivité que présente un nouvel inhibiteur (2PU) vis-à-vis de CDK4 par rapport à CDK2. Les méthodes employées : dynamique moléculaire, calculs d'énergies d'interaction, docking et méthodes mixtes du type ONIOM ont permis d'établir les raisons précises de la sélectivité en mettant en é

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9

Tran, Anh. "Ruthenium-Manganese Complexes as Model Systems for Artificial Photosynthesis." Doctoral thesis, KTH, Chemistry, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3169.

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10

Larsson, Rikard. "Dynamic Systems for Screening, Control and Identification of Protein-Ligand Interactions." Doctoral thesis, Stockholm : Kemi, Chemistry, Kungliga Tekniska högskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4709.

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11

Bunn, Natalie R. "Synthetic and structural studies of low coordinate group 13 ligand systems." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/56114/.

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A new generation of diode lasers is being developed using quantum dots as the gain generating medium. A detailed understanding of the carrier recombination mechanisms and optical gain generation is essential for optimisation of their performance. The aim of this work is to further understand the optical processes occurring in quantum dots. In particular, the effect of the localisation of the energy states in the dots on the recombination mechanisms and the gain/absorption is studied. It is often assumed that the rates of nonradiative recombination via defects, radiative recombination and Auger

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12

Smart, Varrie Russell. "Synthesis of Modular Pseudopeptide Ligand Systems for Modeling Enzyme Active Sites." Miami University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=miami1314145817.

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13

Deitinghoff, Lutz Alexander. "Identifizierung und Charakterisierung eines neuen Ligand-Rezeptor-Systems der retinotectalen Projektion." [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10910385.

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14

Tran-Ho, Lan-Chi. "Redox and binding equilibria of some biologically-interesting metal-ligand systems." Thesis, Tran-Ho, Lan-Chi (1997) Redox and binding equilibria of some biologically-interesting metal-ligand systems. PhD thesis, Murdoch University, 1997. https://researchrepository.murdoch.edu.au/id/eprint/51703/.

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Redox equilibria are important in biology. They determine, for example, the physiological fate of both iron and copper. Given that the redox potential of blood plasma may be as low as -200 mV and that the potential in cells is likely to be considerably lower, the dominant low-molecular-mass species of copper and iron in biological fluids might be Cu(I) and Fe(II) rather than the commonly-assumed Cu(II) and Fe(III). However, this has proved difficult hitherto to investigate due to the absence of reliable formation constants of Cu(I) with complexing agents of likely biological significance and t

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15

Stollberg, Peter. "Synthesis and Characterization of Polydentate C3 Symmetric Ligand Systems in Metal Coordination." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/21.11130/00-1735-0000-0003-C119-7.

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16

Benson, Mark Adam. "N-functionalised cyclotriphosphazenes; towards new polycations , acylation catalysts and zwitterionic ligand systems." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443931.

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17

Tenenbaum, Jessica Dale. "Expression-based ligand signature analysis (ELSA) : a foray into integrative systems medicine /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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18

Pandrapragada, Ravi Kumar. "Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5100.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed Nov. 1, 2007). Vita. Includes bibliographical references.

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19

Rowan, Michael. "a-olefin polymerisation using group V procatalysts bearing calixarenes and related ligand systems." Thesis, University of East Anglia, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432437.

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20

Rodger, Philip J. A. "Development of new mixed metal and ligand systems in s-block amide chemistry." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248980.

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21

Lawlor, Susan Elizabeth. "Synthesis and metal binding properties of novel Câ†2-symmetric tetraaza ligand systems." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342639.

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22

Irwin, Mark Robert Floyd. "The synthesis and characterisation of metal complexes containing chemically reduced bipyridyl ligand systems." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:44dd8d43-01cf-4a2a-ab66-c7cab1d9201f.

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This thesis describes the synthesis and characterisation of metal complexes that contain chemically reduced bipyridyl ligands. The crystal structures of twenty-six novel complexes are reported alongside detailed discussions on the electronic and spectroscopic effects and trends associated with the different oxidation states within these species. Chapter One introduces the isomers of bipyridine and their redox chemistry, the concept of non-innocent ligands and the spectroscopic techniques that are currently used in determining ligand oxidation states. Subsequently, examples of main group, trans

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23

Worbs, Sylvia [Verfasser]. "Charakterisierung der Expression und Modulation des HVEM-BTLA-Ligand-Rezeptor-Systems / Sylvia Worbs." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023747391/34.

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24

Dubé, Tiffany. "Organometallic transformations of di- and trivalent samarium supported by polydentate macrocyclic ligands: Low-valent samarium complexes of di- and tetrapyrrole ligand systems." Thesis, University of Ottawa (Canada), 2000. http://hdl.handle.net/10393/8652.

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SmI2(THF)5 acted as a reducing agent in the reaction with phenylenebis(3,5-But4salicylidene)iminato sodium, (3,5-But4salophen)Na2(THF) 2, to yield a dimeric compound [Sm2(SB-SB)(THF)3] ·2toluene (2.2) [SB-SB = C-C bonded (3,5-Bu t4salophen dimer] arising from the reductive C-C coupling of two imine functional groups of two (3,5-But4salophen)Sm units. Complex 2.2 reacts with MeLi resulting in a novel oxo-bridged dimer, {[(Me2-SB)Sm(mu-CH3)Li(THF)][(Me2-SB)Sm(mu-CH 3)Li(THF)2Li(TBT)2]}(mu-O)(mu-Li)3 (2.3) [Me2SB = phenylenebis (3,5-But 4salicyl)dimethyldiamidato], featuring alkylation of

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25

Dube, Tiffany Lynn. "Organometallic transformations of di-and trivalent samarium supported by polydentate macrocyclic ligands, low-valent samarium complexes of di-and tetrapyrrole ligand systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0020/NQ57037.pdf.

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26

Stocks, Susan Jill. "Development of a general ligand for immunoaffinity partitioning in two phase aqueous polymer systems." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26085.

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The partition of erythrocytes in a two phase aqueous polymer system composed of dextran T500, poly(ethylene glycol)8000 (PEG 8000) and buffer was studied and the effect of a combination of affinity ligands, namely rabbit IgG and PEG 1900 modified monoclonal IgG, was examined as a potential cell separation technique. Several hybridoma lines secreting mouse monoclonal IgG specific for the F[sub c] receptor of rabbit IgG were produced by the fusion of immunised mice spleen cells and mouse myeloma cells. The monoclonal IgG was modified by cyanuric chloride attachment of PEG 1900. The modified mono

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27

Joy, Jonathan Stuart. "Synthesis and charaterisation of mixed s-/p-block organometallics and p-block ligand systems." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402058.

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28

Dane, Sarah Barbara Joanne. "Applications and activation of novel ligand systems in oxidation catalysis and Ylide-based organometallics." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708166.

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29

Finkenauer, Lauren R. "Ligand-Mediated Stabilization of Low Temperature Metal Eutectics and Their Use in Composite Systems." Research Showcase @ CMU, 2017. http://repository.cmu.edu/dissertations/895.

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objective of this thesis is to contribute to the understanding of the behavior of the liquid metal eutectic gallium/indium (EGaIn) in composite systems and provide a platform for the development of functional hybrid nanocomposites. Contributions are regarding (i) the investigation of the electromechanical coupling performance of EGaIn as electrodes in a soft electrostatic transducer and (ii) the effectiveness of organic surfactants to stabilize EGaIn nanoparticles in organic solvents. For the first portion, a completely soft dielectric elastomer actuator (DEA) using EGaIn electrodes was fabric

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30

Nickl, Kathrin. "Establishment of functional cannabinoid receptor test systems and evaluation of ligands derived from Echinacea pallida." kostenfrei, 2008. http://www.opus-bayern.de/uni-regensburg/volltexte/2008/989/.

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31

Pant, Pradeep. "Theoretical studies on the structure and dynamics of symmetric nucleic acids and recognition patterns in DNA- ligand/protein systems." Thesis, IIT Delhi, 2019. http://eprint.iitd.ac.in:80//handle/2074/8087.

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32

Olszak, Torsten Michael. "Expression, Signaltransduktion und biologische Funktionen des CCL20/CCR6-Chemokin-Ligand-Rezeptor-Systems in intestinalen Epithelzellen." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-78674.

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33

Stokes, Emily C. "Amphiphilic ligand architectures for s-, d- and f-block metallosurfactants towards micellar systems and microemulsions." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/106671/.

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The design, synthesis and characterisation of a range of surfactant-based ligand architectures is presented. The amphiphilic ligands have been shown to form metallosurfactants with a wide range of s-, d- and f-block metals as well as being able to form stable micellar systems either through self-assembly or via doping into a carrier microemulsion. The overall aim of this work was to produce surfactant ligands capable of sequestering metal ions and localising them on the surface of micellar droplets within an oil-in-water microemulsion. Chapter Two investigates the formulation and characterisat

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34

OBAIDULLAH, AHMAD J. "USING HYDROPATHIC MOLECULAR MODELING TOOLS TO ENHANCE UNDERSTANDING OF PROTEIN-LIGAND INTERACTIONS IN BIOLOGICAL SYSTEMS." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5156.

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Hydropathic molecular modeling is a computer-aided molecular design technique for obtaining, representing, and understanding the properties and interactions of biomacromolecular complexes in the biological environment. Hydropathic INTeraction (HINT) is a novel empirical force field to calculate the free energy of intermolecular interaction based on experimentally determined partition coefficients (log Po/w). It includes all the expected interactions between molecules such as hydrogen bonding, hydrophobic, electrostatic, acid-base, and Coulombic interactions, entropy, solvation and others. HINT

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35

Pliotas, Christos. "Using biophysical techniques to study the mechanism of ligand-gated potassium efflux systems (KEF) from bacteria." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165422.

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The ligand-gated potassium channels KefC and KefB of <i>Escherichia coli </i>are critical components in protecting cells from toxic electrophiles. Potassium efflux through these channels is coupled to a decrease in cytoplasmic pH which in turn reduces the damage to DNA by electrophiles. KefC and KefB are both inhibited by cytoplasmic glutathione and activated by glutathione adducts, such as ESG, formed by conjugation of glutathione with electrophilic compounds. Robust membrane purification protocols were developed to isolate both the wild type full-length KefC and KefB and the mutants requir

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36

Deitinghoff, Lutz Alexander [Verfasser]. "Identifizierung und Charakterisierung eines neuen Ligand-Rezeptor-Systems der retinotectalen Projektion / vorgelegt von Lutz Alexander Deitinghoff." Tübingen, Danziger Str. 21 : L. A. Deitinghoff, 2003. http://d-nb.info/969759088/34.

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37

Habermeyer, Benoit. "Synthèse et études physico-chimiques de complexes trimétalliques flexibles en séries bisporphyriniques." Thesis, Dijon, 2011. http://www.theses.fr/2011DIJOS025.

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Motivé par leur implication dans le centre réactionnel de l’appareil photosynthétique, puis plus tard, par les défis de la catalyse par transfert multi–électronique, des exemples d'édifices composés de deux porphyrines maintenues face–à–face apparaissent dans les années 70. Les premiers exemples font appel à l’utilisation d’espaceurs rigides qui maintiennent les porphyrines selon une géométrie bien définie permettant d’établir des relations précises entre la structure et les propriétés de ces dérivés. Ce projet de recherche a consisté à synthétiser une « nouvelle génération » de systèmes Pacma

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38

Marchenko, Nataliia. "Effets de ligand sur les propriétés de nanoparticules ultra-petites à base de platine." Electronic Thesis or Diss., Toulouse, INSA, 2023. http://www.theses.fr/2023ISAT0061.

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Les nanoparticules (NP) métalliques ultra-petites possèdent des propriétés uniques en raison de leur taille : un rapport surface sur volume élevé et une quantification de leurs propriétés physiques. Ces caractéristiques en font des objets d'étude populaires en catalyse, en auto-assemblage (AA), en photophysique ou en transport de charge. Des ligands stabilisants sont généralement utilisés pour préserver la petite taille et la dispersion des NP, en plus d'influencer leurs propriétés fonctionnelles. Dans cette thèse, nous étudions comment les ligands peuvent moduler les propriétés intrinsèques d

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39

Sommer, Samantha. "Hybrid Metal-Ligand Hydrogen-Bonded (MLHB) Architectures Based on the Quinolone Subunit: Understanding and Expanding the Accessible Space of Supramolecular Systems." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/19298.

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Despite the prevalence of supramolecular architectures derived from metal-ligand or hydrogen-bonding interactions, few studies have focused on the simultaneous use of these two strategies to form discrete metal-ligand hydrogen-bonded (MLHB) assemblies. The design, synthesis, and characterization of 2-quinolone based hybrid subunits, 7-DPQ and 5-PYQ, that contain phosphine and pyridyl metal binding sites, respectively, is reported. Both subunits give two-fold symmetric hydrogen-bonded tectons that assemble with metal precursors to give hybrid MLHB structures. Treatment of [Cp*RhCl2]2 with t

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40

Franks, David John. "Investigating constitutive activity in G-protein coupled receptors and the effects of prolonged ligand treatments on receptor systems." Thesis, University of Reading, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427857.

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41

Castillo-Montoya, Javier, and Javier Castillo-Montoya. "Development of Orthogonal Split-Kinase and Split-Phosphatase Systems for Interrogating and Rewiring Signal Transduction." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/623179.

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The function of most proteins is regulated by post-translational modifications, of which phosphorylation in particular has been shown to be ubiquitous and of paramount importance to cell signaling. Two enzyme families, protein kinases and phosphatases, regulate phosphorylation, and aberrant activities of family members have been implicated in many diseases such as cancer and neurological disorders. Thus, understanding the function of these enzymes in living cells is important for understanding their biology and for designing new therapies, but a challenging task due to their highly conserved a

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42

Fortin, Ensign Shannon Patricia. "THE TWEAK-FN14 LIGAND RECEPTOR AXIS PROMOTES GLIOBLASTOMA CELL INVASION AND SURVIVAL VIA ACTIVATION OF MULTIPLE GEF-RHO GTPASE SIGNALING SYSTEMS." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/528171.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Glioblastoma (GB) is the highest grade and most common form of primary adult brain tumors, characterized by a highly invasive cell population. GB tumors develop treatment resistance and ultimately recur; the median survival is nearly fifteen months and importantly, the invading cell population is attributed with having a decreased sensitivity to therapeutics. Thus, there remains a necessity to identify the genetic and signaling mec

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43

Landgraf, Corina [Verfasser], and Florian [Akademischer Betreuer] Beigel. "Die Bedeutung des OSM/OSMR-Zytokin-Ligand-Rezeptor-Systems in intestinalen Epithelzellen und bei intestinaler Entzündung / Corina Landgraf ; Betreuer: Florian Beigel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1155097564/34.

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44

Fortin, Ensign Shannon Patricia. "The TWEAK-Fn14 Ligand Receptor Axis Promotes Glioblastoma Cell Invasion and Survival Via Activation of Multiple GEF-Rho GTPase Signaling Systems." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293463.

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Glioblastoma (GB) is the highest grade and most common form of primary adult brain tumors, characterized by a highly invasive cell population. GB tumors develop treatment resistance and ultimately recur; the median survival is nearly fifteen months and importantly, the invading cell population is attributed with having a decreased sensitivity to therapeutics. Thus, there remains a necessity to identify the genetic and signaling mechanisms that promote tumor spread and therapeutic resistance in order to develop new targeted treatment strategies to combat this rapidly progressive disease. TWE

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45

Silver, Nathaniel White. "Ensemble methods in computational protein and ligand design : applications to the Fc[gamma] immunoglobulin, HIV-1 protease, and ketol-acid reductoisomerase systems." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/73372.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2012.<br>In title on title-page, "[gamma]" appears as the lower-case Greek letter. Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 170-192).<br>This thesis explores the use of ensemble, free energy models in the study and design of molecular, biochemical systems. We use physics based computational models to analyze the molecular basis of binding affinity in the context of protein-protein and protein-ligand binding as well as reaction rate enhancement in enzyme catalysis. First, we evalu

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46

Magee, Chad Leroy Keller S. W. "The synthesis and characterization of 1,1'-disubstituted ferrocene imine Schiff base ligand systems for use as potential environmental heavy metal cationic sensors." Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/7117.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb. 23, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dr. Steven W. Keller, Dissertation Supervisor. Vita. Includes bibliographical references.

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47

Kamara, Lamin Mohamed. "Chiral Sulfinamides, n-Oxides & B-Diketimines as Lewis Base Catalysts and Lewis Bases in Synthetic Reactions; the Development of New Ligand Systems." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506938.

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48

Bronova, Anna [Verfasser]. "BonnMag a Computer Program for Angular Overlap Modeling of all fn-Systems: New Insights into Ligand-field splitting of Lanthanide and Actinide ions / Anna Bronova." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1163662364/34.

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49

Kneiseler, Guntje [Verfasser]. "Die funktionelle Bedeutung des Fas-, Fas-Ligand-Systems bei der Immunpathogenese der Sepsis : Untersuchungen zu Promotorpolymorphismen des Fas-Rezeptors bei Patienten mit schwerer Sepsis / Guntje Kneiseler." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1016180667/34.

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50

Wurmthaler, Lena Amelie [Verfasser]. "Influence of ribozyme cleavage in E. coli expression systems and the utilization of ligand-dependent ribozymes for conditional genetic control in C. elegans / Lena Amelie Wurmthaler." Konstanz : KOPS Universität Konstanz, 2018. http://d-nb.info/1219852635/34.

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