Relevant bibliographies by topics / LiGaS2

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
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Academic literature on the topic 'LiGaS2'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "LiGaS2"

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Reshak, Ali H., S. Auluck, I. V. Kityk, Y. Al-Douri, R. Khenata, and A. Bouhemadou. "Electronic properties of orthorhombic LiGaS2 and LiGaSe2." Applied Physics A 94, no. 2 (2008): 315–20. http://dx.doi.org/10.1007/s00339-008-4794-6.

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Vasilyeva, Inga G., and Ruslan E. Nikolaev. "Non-stoichiometry and point native defects in non-oxide non-linear optical large single crystals: advantages and problems." CrystEngComm 24, no. 8 (2022): 1495–506. http://dx.doi.org/10.1039/d1ce01423d.

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Advances and limitations in the field of growing large, high optical quality single crystals of AgGaS2 (AGS), AgGaGeS4 (AGGS), ZnGeP2 (ZGP), LiInS2 (LIS), LiGaS2 (LGS), LiInSe2 (LISe), LiGaSe2 (LGSe) and LiGaTe2 (LGT) are considered in this article.
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Atuchin, V. V., L. I. Isaenko, V. G. Kesler, S. Lobanov, H. Huang, and Z. S. Lin. "Electronic structure of LiGaS2." Solid State Communications 149, no. 13-14 (2009): 572–75. http://dx.doi.org/10.1016/j.ssc.2008.12.048.

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Jelínek, Michal, Milan Frank, Václav Kubeček, et al. "70 MW-Level Picosecond Mid-Infrared Radiation Generation by Difference Frequency Generation in AgGaS2, BaGa4Se7, LiGaSe2, and LiGaS2." IEEE Photonics Journal 17, no. 2 (2025): 1–7. https://doi.org/10.1109/JPHOT.2025.3542540.

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Comparative study of nonlinear crystals for picosecond difference frequency generation in mid-IR is presented. Nonlinear crystals of AgGaS2, BaGa4 Se7, LiGaSe2, and LiGaS2 were studied. In order to investigate the dependence of efficiency on the crystal length, three sets of crystals with lengths of 2, 4, or 8 mm were tested. The developed tunable DFG system was driven by the 1.03 μm, 1.8 ps, Yb:YAG thin-disk laser system operated at the repetition rate of 10 or 100 Hz. As the best result, picosecond mid-IR pulses at a wavelength of ∼7 μm with the energy up to 130 μJ corresponding to the peak power of ∼72 MW were generated using the 8 mm long LiGaS2 crystal. Using the BaGa4 Se7 crystal, DFG tunability in the wavelength range from6 up to 13 μmwas achieved.
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Kumari, J., C. Singh, B. L. Choudhary, and A. S. Verma. "First-principles study for physical properties and stability of Li based chalcopyrite semiconductors: Reliable for green energy sources." Physics and Chemistry of Solid State 23, no. 4 (2022): 728–40. http://dx.doi.org/10.15330/pcss.23.4.728-740.

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In this research study, we have been performed the first principles calculation for physical properties likewise structural, electronic, optical and mechanical properties of the lithium gallium chalcopyrites LiGaX2 (X= S, Se). We have used two exchange correlation potentials one is full potential augmented plane wave method (FP-LAPW) and second is pseudo-potential method. The reported lattice parameters in this work ranging from a = b = 5.28 Å to 5.82 Å and c = 10.11 Å to 11.25 Å and found that these materials have direct band-gap 4.41 eV for LiGaS2 and 2.90 eV for LiGaSe2­. Refractive indexes n(ω) is 2.1 and 2.3 respectively for these compounds. The study of optical and elastic properties for these materials ensures that these show the anisotropic behaviour and ductile in nature.
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Leal-Gonzalez, J., S. A. Melibary, and A. J. Smith. "Structure of lithium gallium sulfide, LiGaS2." Acta Crystallographica Section C Crystal Structure Communications 46, no. 11 (1990): 2017–19. http://dx.doi.org/10.1107/s0108270190002165.

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Kato, Kiyoshi, Nobuhiro Umemura, Ludmila Isaenko, et al. "Thermo-optic dispersion formula for LiGaS2." Applied Optics 58, no. 6 (2019): 1519. http://dx.doi.org/10.1364/ao.58.001519.

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Kurus, Alexey, Alexander Yelisseyev, Sergei Lobanov, et al. "Thermophysical properties of lithium thiogallate that are important for optical applications." RSC Advances 11, no. 62 (2021): 39177–87. http://dx.doi.org/10.1039/d1ra05698k.

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LiGaS2 crystals are grown, and the high thermal conductivity is established. Analysis of temperature dependences of various properties reveals side phases, and isotropic points in birefringence, photo-, thermo-, and pyroluminescence.
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Chen, Bo-Han, Tamas Nagy, and Peter Baum. "Efficient generation of broadband MIR radiation by difference–frequency generation in LiGaS2." EPJ Web of Conferences 205 (2019): 01019. http://dx.doi.org/10.1051/epjconf/201920501019.

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We report a surprisingly infrared (MIR) pulse generation in simultaneous interplay of intra-pulse self-phase-modulation and dispersion. broadband and efficient middle-LiGaS2 (LGS) by invoking a difference frequency generation,
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Dong, Yue Qiu, Yi Yin, Jin Jer Huang, et al. "Optimization on the frequency conversion of LiGaS2 crystal." Laser Physics 29, no. 9 (2019): 095403. http://dx.doi.org/10.1088/1555-6611/ab3847.

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Dissertations / Theses on the topic "LiGaS2"

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Nandakumar, Jayakrishnan. "Discrimination of RNA versus DNA by an RNA ligase and distinct modes of substrate recognition by DNA ligases /." Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1428838891&sid=13&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Fan, Jun. "Investigating the crosstalk between Nedd4 ubiquitin ligases and PIAS3 SUMO ligase." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/31791.

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Previously it has been shown that Rsp5p, a member of Nedd4 ubiquitin ligases in yeast, is modified by the ubiquitin-like protein SUMO and that this modification is performed by Siz1p, a member of PIAS SUMO ligases that are in turn substrates of Rsp5p-dependent ubiquitylation, thus defining a previously unidentified system of crosstalk between the ubiquitin and SUMO systems in yeast. This project aims to identify whether similar crosstalk pattern exists in human cells. In vitro ubiquitylation assays showed that some of the human Nedd4 family members (Nedd4.1, Nedd4.2, WWP1) are capable of ubiquitylating the human SUMO ligase PIAS3, while in contrast, Smurf2 does not appear to be able to modify this protein. This modification is partially WW-PY-motif-dependent as ubiquitylation level of PIAS3 mutants with altered PY motifs conducted by Nedd4.1 or Nedd4.2 was reduced, but not completely disrupted. Interestingly, in vitro SUMOylation assay revealed that Nedd4.1 is SUMOylated even in the absence of SUMO E3 ligases and an apparent interaction between the SUMO E2 (Ubc9) and Nedd4.1 was observed both in vitro and in vivo. I show that auto- SUMOylation of Nedd4.1 is accompanied with the formation of thioester-linked conjugates between Nedd4.1 and SUMO, but these do not involve cysteine residues (C867, C778, and C627) within the HECT domain itself and is not occurring at a predicted SUMOylation consensus site (K357). Furthermore, I have shown that Nedd4.1 and SUMO1/2 colocalize in HeLa cells, and that overexpression of epitope tagged Nedd4 and SUMO1/2, followed by denaturing pull-downs demonstrates that both Nedd4.1 and Nedd4.2 can be SUMOylated in vivo. Meanwhile, I have generated a SUMO trap based on SUMO interacting motifs (SIMs) and confirmed its ability of capturing SUMOylated proteins both in vivo and in vitro. Its use reveals that Nedd4 SUMO conjugates could be captured by SUMO trap when Nedd4 and SUMO were co-expressed in HeLa cells, again confirming Nedd4.1 as a substrate for SUMO1 or SUMO2. In conclusion, I show that SUMOylation of Nedd4.1 does exist in HeLa cells, and on the other hand, some of Nedd4 family members are responsible for PIAS3 ubiquitylation in vitro, providing evidence of a crosstalk between Nedd4 family of ubiquitin ligases and PIAS family of SUMO ligases in mammals.
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Wang, Shao-Fang. "Biochemical and biophysical studies of MDM2-ligand interactions." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9527.

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MDM2, murine double minute 2, is a RING type-E3 ligase protein and also an oncogene. MDM2 plays a critical role in determining the steady levels and activity of p53 in cells using two mechanisms. The N-terminal domain of MDM2 binds to the transactivation domain of p53 and inhibits its transcriptional activity. The RING domain of MDM2 plays a role in the ubiquitination (and degradation) of p53. Several proteins are responsible for the ubiquitination mechanism including the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2) and ubiquitin ligase (E3). Since the E2-E3 interaction is essential for ubiquitination, the protein-protein recognition site is a potential drug target. Two different MDM2 RING constructs were expressed and purified: MDM2RING (residues 386-491) and MDM2RING△C (residues 386-478). Both constructs were characterised using dynamic light scattering, size exclusion chromatography, mass spectrometry, NMR and electron microscopy. E3 ligase activity in vitro was also studied. Taken together these results showed that the MDM2RING construct formed a concentration-dependent oligomeric structure. In contrast, the MDM2RING△C construct formed a dimer at all concentrations. Both MDM2RING and MDM2RING △ C retain E3 ligase activity. However, the MDM2RING△C construct is less active. Full length E2 enzyme UbcH5a was also purified. Various biophysical techniques were used to study its interaction with MDM2 as well as with potential small molecule inhibitors as in principle, small molecules which disrupt the interaction between MDM2 and UbcH5a, could prevent/promote ubiquitination of p53. The dimerisation of MDM2 is important for its E3 activity and the C8-binding site potentially provides a second druggable site. In this work, peptide 9, which has the same sequence as the C-terminus of MDMX (an MDM2 homologue) was found to inhibit MDM2 E3 activity. Various biological techniques including NMR, fluorescence anisotropy, and electrospray mass spectrometry were used to investigate the interaction between two inhibitory peptides and MDM2. A major part of project involved virtual screening (VS) to search for small molecules which can affect MDM2-dependent ubiquitination. Three potential targets were considered: (1) the C8-binding site of MDM2; (2) the UbcH5a-binding site of MDM2; and (3) the MDM2-binding site of UbcH5a. Several small molecules were identified using our virtual screening database-mining and docking programs that were shown to affect MDM2-dependent ubiquitination of p53. In terms of understanding the complex biochemical mechanism of MDM2 this work provides two interesting and functionally relevant observations: (i) the MDM2 RING△C construct is a dimer as this would not be expected form the existing studies, and has less E3 ligase activity than MDM2RING; (ii) small molecules that bind MDM2 on the E2 binding site enhanced E3 ligase activity. One model to explain these observations is that binding of small molecule activators family to the RING induces a change in the conformation of the Cterminal tail residues which may enhance E2 binding.
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Lotte, Romain. "Caractérisation des interactions moléculaires entre la GTPase Rac1 et son régulateur HACE1 : perspectives en infectiologie et en cancérologie." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4087.

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La GTPase Rac1 est une protéine de signalisation intracellulaire qui joue notamment un rôle clé dans la prolifération cellulaire. Notre laboratoire a montré que la toxine CNF1, produite par les Escherichia coli pathogènes, catalyse l’activation de Rac1. Nous avons également identifié le rôle de la E3 ubiquitine-ligase HACE1, un suppresseur de tumeur avéré, dans la régulation par ubiquitylation de Rac1 actif. S’il est prouvé que la forme activée de Rac1 est une cible d’HACE1, le mode d’interaction de ces deux protéines reste à définir ainsi que le rôle de ces interactions dans l’infection et le cancer. L’objectif de mon travail a été de caractériser les interactions moléculaires entre HACE1 et Rac1. Nous avons testé l’hypothèse que des mutations ponctuelles d’HACE1 identifiées dans les cancers pourraient interférer avec son interaction avec Rac1 et sa capacité de contrôle de la croissance cellulaire. J’ai ainsi pu mettre en évidence que 13 mutations somatiques d’HACE1 issues de tumeurs séquencées altèrent sa fonction de contrôle de la croissance cellulaire. De plus, l’étude de ces mutations nous a permis d’identifier un groupe d’acides aminés, situés sur les ankyrin-repeats 5 à 7 d’HACE1, qui contrôle l’interaction d’HACE1 avec Rac1 et de ce fait son ubiquitylation. Enfin dans cette étude nous précisons le rôle du domaine intermédiaire d’HACE1 (MID) dans la spécificité d’interaction de la ligase avec la forme active de Rac1. In fine, la caractérisation de mutants d’interaction entre HACE1 et Rac1 ainsi que l’effet de la toxine CNF1 sur cet axe de signalisation doit nous renseigner sur l’importance de cette voie de régulation dans le cancer et l’infection<br>The small GTPase Rac1 plays a key role in various intracellular signaling pathways including cell proliferation. Our laboratory has shown that the CNF1 toxin, produced by pathogenic Escherichia coli, catalyzes the activation of Rac1. We also identified the role of the E3 ubiquitin-ligase HACE1, a tumor suppressor, in the regulation by ubiquitylation of active Rac1. If the activated form of Rac1 is proved to be a target of HACE1, the mode of interaction between these two proteins remains to be define as well as the role of these interactions in infection and cancer. The aim of my work was to characterize the molecular interactions between HACE1 and Rac1. We tested the hypothesis that HACE1 point mutations identified in cancers could interfere with its interaction with Rac1 and its ability to control cell growth. We showed that 13 cancer-associated somatic mutations of HACE1, led to a defective control of cell proliferation. Moreover, the study of these mutations allowed us to identify a group of amino acids, located on the ankyrin-repeats 5 to 7 of HACE1, which controls the interaction of HACE1 with Rac1 and thus its ubiquitylation. We also identified a role for the intermediate domain of HACE1 (MID) in conferring the specificity of association of HACE1 to the active form of Rac1. Ultimately, the characterization of interaction mutants between HACE1 and Rac1 as well as the effect of the CNF1 toxin on this signaling axis will give us more insight on this regulatory pathway in cancer and infection
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Lelievre, Chloé. "Formation de liaisons amides par réactions enzymatiques détournées ATP Regeneration System in Chemoenzymatic Amide Bond Formation with Thermophilic CoA Ligase." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASF026.

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La fonction amide est omniprésente dans les produits naturels et aussi dans de nombreux composés synthétiques comme des principes actifs et des polymères. De nombreuses approches ont été développées pour disposer de méthodes de synthèse efficaces. L'approche la plus courante en chimie conventionnelle est l'acylation d'une amine par un acide carboxylique activé. L'activation nécessite l'utilisation soit d'agents de couplage, résultant en une faible économie d'atomes, soit de catalyseurs couteux parfois utilisés dans des conditions drastiques. Les approches biocatalytiques sont donc des alternatives intéressantes pour des raisons économiques et environnementales. Différentes enzymes peuvent être utilisées comme des hydrolases, des nitrile hydratases et des transglutaminases qui activent l'acide sous forme acyl-enzyme pour favoriser l'addition nucléophile de l'amine. Depuis quelques années, l'intérêt pour les enzymes dépendantes de l'ATP s'est accru.Dans ce projet, nous nous sommes intéressés aux CoA ligases qui catalysent la formation d'acide activé sous forme d'acyl-adenylate puis acyl-thioester. Nous avons ainsi mis en évidence qu'en détournant la réaction par piégeage de l'intermédiaire activé par une amine, nous obtenons l'amide. L'utilisation de CoA ligases thermophiles permet de travailler à une température élevée et ainsi de faciliter l'addition non catalysée de l'amine. Ce système s'affranchit donc de l'utilisation de HSCoA onéreux. Pour un système efficace, nous avons aussi intégré avec succès un système de régénération de l'ATP comprenant une Polyphosphate Kinase 2 (Classe III) et une inorganique pyrophosphatase. L'efficacité de cette cascade a été illustrée par la synthèse chemo-enzymatique à l'échelle du laboratoire du N-méthylbutyrylamide avec un rendement de 77 % avec de faibles quantités en enzyme.L'exploration de la biodiversité par approche génomique basée sur la comparaison de séquence, nous a permis d'identifier plusieurs CoA ligases thermophiles actives sur des substrats ω-amino acides précurseurs de lactames. K6Q029 issue de Thermaerobacter subterraneus a fait l'objet d'études plus approfondies. Elle est notamment active sur des substrats ω-amino acides fonctionnalisés ou non, de chaines carbonées plus ou moins longues, mais aussi sur des acides carboxyliques variés tels que des aromatiques.Grâce à la résolution structurale d'A4YDT1, une CoA ligase promiscuitaire, nous avons identifié, en collaboration avec une équipe de cristallographes de l'université de Groningen (Pays Bas), les résidus impliqués dans sa spécificité de substrats pour les modifier par une approche rationnelle. Des mutants de cette enzyme ont ainsi permis l'obtention de δ-valerolactame et Ɛ-caprolactame<br>The amide function is widespread in nature and also in many synthetic products such as pharmaceuticals and polymers. Numerous approaches have been developed to provide reliable synthesis methods. The most common approach in conventional chemistry is the acylation of an amine by activated carboxylic acid. Activation requires the use of either coupling reagents resulting in low atom economy, or expensive catalysts sometimes used under drastic conditions. Biocatalytic approaches are therefore interesting alternatives for economic and environmental reasons. Different enzymes can be used such as hydrolases, nitrile hydratases and transglutaminases that activate the acid in acyl-enzyme form to promote the nucleophilic addition of the amine. In recent years, interest in ATP-dependent enzymes has increased.In this project, we focused on CoA ligases that catalyze the formation of activated acid as acyl-adenylate and then acyl-thioester. We have thus demonstrated that by diverting the reaction by scavenging activated intermediate with an amine, we obtain the amide. The use of thermophilic CoA ligases allows us to work at a high temperature and thus facilitate the uncatalyzed addition of the amine. This system therefore dispenses with the use of expensive HSCoA. For a better system, we have also successfully integrated an ATP regeneration system with a Polyphosphate Kinase 2 (Class III) and an inorganic pyrophosphatase. The efficiency of this cascade was illustrated by the lab-scale chemo-enzymatic synthesis of N-methylbutyrylamide in 77 % yield using low enzyme loading.Biodiversity exploration using a genomic approach based on sequence comparison allowed us to identify several thermophilic CoA ligases active towards ω-amino acid substrates. K6Q029 from Thermaerobacter subterraneus was further studied. In particular, this enzyme is active towards ω-amino acid substrates, functionalized or not, with more or less long carbon chains, as well as on various carboxylic acids such as aromatics.Thanks to the structural resolution of A4YDT1, a promiscuous CoA ligase from the literature, we have identified, in collaboration with a team of crystallographers from theUniversity of Groningen (Netherlands), the residues involved in its substrate specificity to modify them by a rational approach. Variants of this enzyme have thus allowed to obtain δ-valerolactam and Ɛ-caprolactam
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El, Hachem Najla. "Rôle pro-tumorigénique de HACE1 dans le mélanome." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4035.

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L’incidence du mélanome a augmenté de façon considérable lors des trente dernières années avec un doublement tous les dix ans. Le mélanome ne représente que 5% des cancers cutanés mais entraîne 80% de décès, ce qui constitue un problème majeur de santé publique. En effet, cette tumeur est extrêmement agressive et possède un fort potentiel métastatique. Dès l’apparition de métastases, le pronostic vital devient fortement défavorable. Malgré des avancées thérapeutiques majeures, de nombreux patients sont encore réfractaires à ces nouveaux traitements. La compréhension des mécanismes impliqués dans le développement de cette tumeur reste donc un enjeu de premier ordre. Le séquençage d'exomes a conduit à l'identification d'une mutation dans le gène RAC1 (la mutation P29S) constituant une des mutations somatiques les plus fréquentes dans le mélanome (après les mutations BRAFV600, NRASQ61 et NF1). RAC1 est une petite GTPase qui fonctionne dans plusieurs processus cellulaires. Dans des conditions physiologiques, l'activité de RAC1 est principalement contrôlée par des protéines activatrices de l'activité GTPase (GAPs) et des facteurs d'échange Nucléotidique (GEF). GAPs et GEFs contrôlent le niveau de RAC1-GTP et régulent donc son activité. L'activité de RAC1 est aussi dépendante de son niveau d'expression protéique qui est contrôlé par des E3 ubiquitine ligases, parmi lesquelles HACE1. HACE1 est considérée comme un suppresseur de tumeur. De façon inattendue, les données obtenues montrent clairement que HACE1 favorise les propriétés migratoires et tumorigéniques des cellules de mélanome<br>Melanoma incidence has considerably increased over the last thirty years, with a doubling every ten years. Melanoma accounts for only 5% of cutaneous cancers but causes more than 80% of deaths, which is a major public health problem. Indeed, this tumor is extremely aggressive and has a high metastatic potential. After the onset of metastases, the prognosis becomes highly unfavorable. Despite major therapeutic advances, many patients are still refractory to these new treatments. Understanding the mechanisms involved in the development of this tumor and the identification of new therapies remain a major issue. The sequencing of exomes led to the identification of a mutation in the RAC1 gene (P29S) constituting one of the most frequent somatic mutations in melanoma (after the BRAFV600, NRASQ61 and NF1 mutations). RAC1 is a small GTPase that is involved in several key cellular processes. Under physiological conditions, the activity of RAC1 is mainly controlled by GTPase activating proteins (GAPs) and Nucleotide Exchange (GEF) exchange factors. GAPs and GEFs control the level of RAC1- GTP and thus regulate its activity. The activity of RAC1 is also dependent on its protein level of expression which is controlled by E3 ubiquitin ligases, including HACE1. HACE1 is considered a tumor suppressor. Unexpectedly, our data clearly show that HACE1 promotes migratory and tumorigenic properties of melanoma cells. Indeed, inhibition of HACE1 alters migration of melanoma cells in vitro, as well as in vivo pulmonary colonization in mice. Transcriptomic analysis of 4 melanoma cell lines demonstrated that HACE1 suppression inhibits ITGAV and ITGB1 expression
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Oliveira, Rogério Alves. "O forjamento de ligas de alumínio : um estudo para a liga ABNT 6061." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2001. http://hdl.handle.net/10183/2302.

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Este trabalho pretende, na visão de novas tecnologias, discutir o processo de forjamento das ligas de alumínio (ABNT 6061), buscando propor uma metodologia baseada na ciência da engenharia. Deseja-se minimizar os procedimentos de tentativa e erro no desenvolvimento de processos de conformação. Para tanto, novas tecnologias disponíveis atualmente, tais como o Projeto Assistido por Computador (CAD), a Fabricação Assistida por Computador (CAM) e a Simulação do Processo (CAE) são empregadas. Resultados experimentais mostrando o comportamento da liga ABNT 6061 através das curvas de escoamento bem como o estabelecimento da condição do atrito no processo de conformação, avaliando dois lubrificantes comerciais disponíveis (Deltaforge 31 e Oildag) para aplicações nas ligas de alumínio, são reportados neste trabalho. A comparação dos resultados obtidos de um experimento prático de forjamento com a simulação pelo “Método dos Elementos Finitos” usando o código “QForm” é apresentada para uma peça de simetria axial em liga de alumínio. Finalmente, os resultados obtidos no forjamento de um componente automotivo em liga de alumínio (ABNT 6061), desenvolvido em parceria com a empresa Dana, são analisados e comparados com as simulações computacionais realizadas usando o código “Superforge”.<br>This work intends, on the view of new technologies, to discuss the forging process of aluminum alloys (ABNT 6061) and aims at proposing a methodology based on the engineering science. It is desired to minimize trial and error procedures in the development of forming processes. For such, new technologies available today, such as Computer Aided Design (CAD), Computer Aided Manufacturing (CAM) and Computer Aided Engineering (CAE) are employed. Experimental results showing the behaviour of an ABNT 6061 through flow curves as well as the establishment of friction conditions in the forming process by evaluating two commercially-available lubricants (c.e., Deltaforge 31 and Oildag) for aluminum alloys applications are reported in this work. A comparision of the results obtained from a forging experiment with finite element method (F.E.M.) simulations using “QForm” code is presented for an axially-simmetric part made of aluminum alloy. Finally, forging results of an automotive component made of an aluminum alloy (ABNT 6061) developed in partnership with DANA, area analyzed and compared to F.E.M. computational simulations obtained through the SuperForge software.
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El, Hachem Najla. "Rôle pro-tumorigénique de HACE1 dans le mélanome." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4035.

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L’incidence du mélanome a augmenté de façon considérable lors des trente dernières années avec un doublement tous les dix ans. Le mélanome ne représente que 5% des cancers cutanés mais entraîne 80% de décès, ce qui constitue un problème majeur de santé publique. En effet, cette tumeur est extrêmement agressive et possède un fort potentiel métastatique. Dès l’apparition de métastases, le pronostic vital devient fortement défavorable. Malgré des avancées thérapeutiques majeures, de nombreux patients sont encore réfractaires à ces nouveaux traitements. La compréhension des mécanismes impliqués dans le développement de cette tumeur reste donc un enjeu de premier ordre. Le séquençage d'exomes a conduit à l'identification d'une mutation dans le gène RAC1 (la mutation P29S) constituant une des mutations somatiques les plus fréquentes dans le mélanome (après les mutations BRAFV600, NRASQ61 et NF1). RAC1 est une petite GTPase qui fonctionne dans plusieurs processus cellulaires. Dans des conditions physiologiques, l'activité de RAC1 est principalement contrôlée par des protéines activatrices de l'activité GTPase (GAPs) et des facteurs d'échange Nucléotidique (GEF). GAPs et GEFs contrôlent le niveau de RAC1-GTP et régulent donc son activité. L'activité de RAC1 est aussi dépendante de son niveau d'expression protéique qui est contrôlé par des E3 ubiquitine ligases, parmi lesquelles HACE1. HACE1 est considérée comme un suppresseur de tumeur. De façon inattendue, les données obtenues montrent clairement que HACE1 favorise les propriétés migratoires et tumorigéniques des cellules de mélanome<br>Melanoma incidence has considerably increased over the last thirty years, with a doubling every ten years. Melanoma accounts for only 5% of cutaneous cancers but causes more than 80% of deaths, which is a major public health problem. Indeed, this tumor is extremely aggressive and has a high metastatic potential. After the onset of metastases, the prognosis becomes highly unfavorable. Despite major therapeutic advances, many patients are still refractory to these new treatments. Understanding the mechanisms involved in the development of this tumor and the identification of new therapies remain a major issue. The sequencing of exomes led to the identification of a mutation in the RAC1 gene (P29S) constituting one of the most frequent somatic mutations in melanoma (after the BRAFV600, NRASQ61 and NF1 mutations). RAC1 is a small GTPase that is involved in several key cellular processes. Under physiological conditions, the activity of RAC1 is mainly controlled by GTPase activating proteins (GAPs) and Nucleotide Exchange (GEF) exchange factors. GAPs and GEFs control the level of RAC1- GTP and thus regulate its activity. The activity of RAC1 is also dependent on its protein level of expression which is controlled by E3 ubiquitin ligases, including HACE1. HACE1 is considered a tumor suppressor. Unexpectedly, our data clearly show that HACE1 promotes migratory and tumorigenic properties of melanoma cells. Indeed, inhibition of HACE1 alters migration of melanoma cells in vitro, as well as in vivo pulmonary colonization in mice. Transcriptomic analysis of 4 melanoma cell lines demonstrated that HACE1 suppression inhibits ITGAV and ITGB1 expression
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Eimutienė, Neringa. "Sergančių onkologine liga asmenų ligos suvokimo sąsajos su gyvenimo prasme ir ligos įveikimo strategijomis." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130603_143815-35512.

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Tyrimo tikslas – nustatyti sergančių onkologine liga asmenų, vyrų ir moterų, ligos suvokimo sąsajas su gyvenimo prasme ir ligos įveikos strategijomis. Tyrimui atlikti naudota: Ligos suvokimo klausimynas (Weinman, Petrie, Moss-Morris, Horne, 1996; Weinman, Petrie, 1997) (angl. The Revised-Illness Perception Questionnaire, IPQ–R), siekiant nustatyti vėžiu sergančių asmenų ligos suvokimą; Gyvenimo prasmės skalė (Jim et al., 2006) (angl. Meaning in Life Scale, MiLS), skirta tiriamųjų gyvenimo prasmės įvertinimui; COPE streso įveikimo strategijų klausimynas Carver, Scheier, Weintraub, 1989) (angl. Coping Orientation of Problem Experience Inventory, COPE), siekiant nustatyti tiriamųjų pasirinktas ligos įveikos strategijas. Gauti duomenys apdoroti naudojant statistinį SPSS 16,0 versijos programinį paketą. Statistiškai patikimais rezultatais laikytini atvejai, kai p < 0,05, P = 95 proc. Tyrime dalyvavo 142 (22–74 metų) onkologinėmis ligomis sergantys vyrai ir moterys. Tyrimo rezultatai parodė, kad onkologine liga sergančių asmenų, vyrų ir moterų, stipresnis ligos suvokimas siejasi su dažniau naudojama adaptyvia, į problemas nukreipta ligos įveika; onkologine liga sergančių asmenų, vyrų ir moterų, stipresnis ligos suvokimas siejasi su aukštesne gyvenimo prasme; onkologine liga sergantiems asmenims, vyrams ir moterims, pasižymintiems stipresniu ligos suvokimu ir adaptyvia, į emocijas nukreipta ligos įveika, būdinga žemesnė gyvenimo prasmė.<br>The aim of the research is to identify oncology patients’, men and women, relation of illness perception to the meaning in life, the coping strategies of illness. References for research: The Revised-Illness Perception Questionnaire, IPQ–R (Weinman, Petrie, Moss-Morris, Horne, 1996; Weinman, Petrie, 1997) in order to identify oncology patients’ illness perception; Meaning in Life Scale, MiLS (Jim et al., 2006) for evaluation of research participants’ meaning in life; Coping Orientation of Problem Experience Inventory, COPE (Carver, Scheier, Weintraub, 1989) in order to identify the coping strategies of illness chosen by research participants. The received data was processed while using a statistical SPSS software package. Statistically reliable cases werw considered when p < 0,05, P = 95%. 142 people (22-74years old), men and women with oncologic illnesses participated in the research. The research results have revealed that a stronger illness perception of men and women with oncologic illness is associated with a more frequently used adaptive, problem-focused coping of illness; a stronger illness perception of men and women with oncologic illness is associated with a higher meaning in life; a lower meaning in life is typical for those oncology patients, men and women, who have a stronger illness perception and adaptive, emotion - focused illness coping.
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Ribau, Humberto Miranda. "Soldadura laser pulsado Nd: YAG entre metais dissimulares." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/23358.

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Mestrado em Engenharia Mecânica<br>A presente investigação consiste no estudo experimental das propriedades mecânicas induzidas pela soldadura laser em chapas de materiais metálicos dissimilares, nomeadamente, aço de alta resistência dual-phase (DP) 600 com aço de alta resistência dual-phase (DP) 1000 e liga de alumínio AA6060-T6 com liga de titânio Ti-6Al-4V. No caso dos aços dual-phase, o estudo foi realizado em amostras de 0,8 mm de espessura, numa junta do tipo topo a topo. Após a seleção dos parâmetros mais adequados para a soldadura, foram efetuados ensaios de tração aos provetes soldados, com o objetivo de determinar as propriedades mecânicas e avaliar a influência dos parâmetros do laser. Em relação à ligação de alumínio com titânio, esta foi feita numa junta de sobreposição dupla em amostras de 1,9 e 0,9 mm de espessura, respetivamente. Do mesmo modo que os aços, foram também variados os parâmetros do laser, de modo a se obter os mais adequados, para posteriormente se efetuar ensaios de tração. Variou-se também o sítio onde o feixe laser incide na junta de sobreposição para melhor avaliar a soldadura.<br>The aim of this thesis consists of an experimental study of the mechanical properties induced by the laser welding in dissimilar metal, namely, dual-phase steel 600 with dual-phase steel 1000 and aluminium alloy AA6060-T6 with titanium alloy Ti-6Al-4V. In the case of the dual-phase steels, the study was carried out on 0,8 mm plates, in a butt joint type. After selecting the most appropriate parameters for the welding, tensile tests were performed on welded specimens with the purpose to find the mechanical properties and evaluate the influence of the laser parameters. The aluminium - titanium union was accomplished on a double-lap joint on 1,9 mm and 0,9 mm plates, respectively. Just like the situation of the steels, the laser parameters were too varied with aim to obtain the most appropriate parameters, to later perform tensile tests. It was also changed the place where the laser beam impacts on the specimen, to better analyse the welding.
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Books on the topic "LiGaS2"

1

Gómez, Ramón Terol. Las ligas profesionales. Fundación del Fútbol Profesional, 1998.

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Cruz, Héctor J., and Rolín Fermín. Dominicanos en grandes ligas: Anuario. 2nd ed. Edited by CODETEL (Firm). CODETEL, 2002.

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Barbosa, Cassio. Caracterização: Ligas de alumínio extrudadas/soldadas p/centelhamento: Ligas AA 6013 e AA 6061. Novas Edições Acadêmicas, 2017.

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Oleksak, Michael M. Béisbol: Latinoamericanos en las Grandes Ligas. EDAMEX, 1995.

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Benítez, José A. Crescioni. Los boricuas en las grandes ligas. s.n.], 1995.

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Pedro, Stédile João, Morais Clodomir, Aued Bernardete Wrublevski, and Page Joseph A, eds. História e natureza das Ligas Camponesas. Editora Expressão Popular, 2002.

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Morais, Clodomir. História das Ligas Camponesas do Brasil. Edições Instituto de Apoio Técnico aos Países de Terceiro Mundo, 1997.

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Nienhaus, G. Ulrich. Protein-Ligand Interactions. Humana Press, 2005. http://dx.doi.org/10.1385/1592599125.

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Daviter, Tina, Christopher M. Johnson, Stephen H. McLaughlin, and Mark A. Williams, eds. Protein-Ligand Interactions. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1197-5.

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Williams, Mark A., and Tina Daviter, eds. Protein-Ligand Interactions. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-398-5.

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Book chapters on the topic "LiGaS2"

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Sandeep Vyas, Manish Tiwari, Takasumi Tanabe, and Ghanshyam Singh. "Chalcogenide (LiGaSe2, LiGISe, LiGaS2): A Perfect Material to Design Highly Nonlinear PCFs for Supercontinuum Generation." In Proceedings of the International Conference on Recent Cognizance in Wireless Communication & Image Processing. Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-2638-3_47.

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Cleaves, Henderson James. "Ligase." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_882-3.

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Cleaves, Henderson James. "Ligase." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_882.

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Cleaves, Henderson James. "Ligase." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_882.

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Cleaves, Henderson James. "Ligase." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-642-27833-4_882-4.

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Cleaves, Henderson James. "Ligase." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-65093-6_882.

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Gooch, Jan W. "Ligase." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14117.

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Seelig, Burckhard. "RNA Ligase." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_5316.

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Seelig, Burckhard. "RNA Ligase." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-65093-6_5316.

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Seelig, Burckhard. "RNA Ligase." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_5316-2.

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Conference papers on the topic "LiGaS2"

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MORAES, LUCAS ALVES DE, LÍVIA CARLOS CIDRÃO, JOSÉ ADROALDO SILVA DE MOURA FILHO, et al. "INVESTIGAÇÃO MICROESTRUTURAL E MICROQUÍMICA DE INTERFACES DISSIMILARES DE AÇO BAIXA-LIGA E LIGAS DE NÍQUEL PARA APLICAÇÃO SUBSEA." In 77º Congresso Anual da ABM - Internacional. Editora Blucher, 2024. http://dx.doi.org/10.5151/2594-5327-41454.

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Jelínek, Michal, Václav Kubeček, Ondřej Novák та ін. "Difference Frequency Generation in BaGa4Se7, LiGaSe2, or LiGaS2 with Output Energy up to 100 μJ Tunable in a 5 to 13 μm Range Pumped by a 1.03 μm, 1.8 ps Laser". У Advanced Solid State Lasers. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/assl.2022.jw3b.15.

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Chandra, S., and V. Kumar. "Thermodynamic Properties of LiGaS2 and LiGaSe2 using First-Principle Calculations." In 2018 5th IEEE Uttar Pradesh Section International Conference on Electrical, Electronics and Computer Engineering (UPCON). IEEE, 2018. http://dx.doi.org/10.1109/upcon.2018.8596990.

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Chandra, Satish, V. Kumar, and Yadvendra Singh. "First-principle calculations of Debye temperature of optoelectronic LiGaS2 and LiGaSe2 semiconductors under different pressures." In Optical Components and Materials XVI, edited by Michel J. Digonnet and Shibin Jiang. SPIE, 2019. http://dx.doi.org/10.1117/12.2506878.

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Zhou, Lu, Ondřej Novák, Martin Smrž, and Tomáš Mocek. "Study of Broadband Mid-infrared Optical Parametric Amplification in LiGaS2, LiGaSe2, LiInS2, and LiInSe2 Crystals." In Compact EUV & X-ray Light Sources. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/euvxray.2022.jw5a.17.

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Tyazhev, Aleksey, Vitaly Vedenyapin, Georgi Marchev, et al. "Mid-IR optical parametric oscillator based on LiGaS2." In 12th European Quantum Electronics Conference CLEO EUROPE/EQEC. IEEE, 2011. http://dx.doi.org/10.1109/cleoe.2011.5942751.

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Ishii, Nobuhisa, Keisuke Kaneshima, Nariyuki Saito, et al. "Phase-stable ultrafast MIR sources for high harmonic generation in solids." In CLEO: Applications and Technology. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleo_at.2022.jm2e.5.

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We develop Ti:sapphire- and Yb-laser pumped mid-infrared sources with stable carrier-envelope phases using LiGaS2 (LGS), KTiOAsO4 (KTA) and GaSe crystals. These light sources are used to explore the physics of high harmonic generation in solids.
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Atuchin, Victor V., Ludmila I. Isaenko, Valeriy G. Kesler, Zheshuai Lin, and S. I. Lobanov. "Exploration of optical and electronic parameters of lithium thiogallate (LiGaS2)." In 2011 12th International Conference and Seminar of Young Specialists on Micro/Nanotechnologies and Electron Devices (EDM 2011). IEEE, 2011. http://dx.doi.org/10.1109/edm.2011.6006881.

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Qu, Shizhen, Houkun Liang, Xiao Zou, et al. "High-energy 9 µm LiGaS2-based Optical Parametric Chirped-Pulse Amplifier." In CLEO: Applications and Technology. OSA, 2019. http://dx.doi.org/10.1364/cleo_at.2019.jw2a.40.

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Umemura, Nobuhiro, Kiyoshi Kato, Takayuki Okamoto, and Valentin Petrov. "Upconversion of the mid-IR pulses to the near-IR in LiGaS2." In Nonlinear Frequency Generation and Conversion: Materials and Devices XVII, edited by Konstantin L. Vodopyanov and Kenneth L. Schepler. SPIE, 2018. http://dx.doi.org/10.1117/12.2286762.

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Reports on the topic "LiGaS2"

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Royer, Lacey. Cul3 Ubiquitin Ligase and Ctb73 Protein Interactions. Portland State University Library, 2014. http://dx.doi.org/10.15760/honors.48.

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Diaz Arenas, Carolina. Evolutionary Dynamics in Molecular Populations of Ligase Ribozymes. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.44.

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Raj, Ganesh V. Targeting Ligand Dependent and Ligand Independent Androgen Receptor Signaling in Prostate Cancer. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613818.

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Raj, Ganesh V. Targeting Ligand-Dependent and Ligand-Independent Androgen Receptor Signaling in Prostate Cancer. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada604653.

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Zhang, Hui. The Role of Ubiquitin E3 Ligase SCFSKP2 in Prostate Cancer Development. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada435854.

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Davidge, Brittney. The Cul3 Ubiquitin Ligase: An Essential Regulator of Diverse Cellular Processes. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.5666.

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Shanoski, Jennifer E. Ligand Rearrangements of Organometallic Complexes inSolution. Office of Scientific and Technical Information (OSTI), 2006. http://dx.doi.org/10.2172/883798.

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Gladysz, J. A. Ligand intermediates in metal-catalyzed reactions. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/5977342.

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Gladysz, John A. Ligand Intermediates in Metal-Catalyzed Reactions. Office of Scientific and Technical Information (OSTI), 1999. http://dx.doi.org/10.2172/758776.

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Chen, Ceshi. The Oncogenic Role of WWP1 E3 Ubiquitin Ligase in Prostate Cancer Development. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada549835.

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