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Relevant bibliographies by topics / Light chain IgG

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Academic literature on the topic 'Light chain IgG'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "Light chain IgG"

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Veber, Alexander, Dennis Lenau, Polyniki Gkragkopoulou, et al. "Impact of Light-Chain Variants on the Expression of Therapeutic Monoclonal Antibodies in HEK293 and CHO Cells." Antibodies 14, no. 3 (2025): 53. https://doi.org/10.3390/antib14030053.

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Recombinantly produced monoclonal antibodies (mabs) belong to the fastest growing class of biotherapeutics. In humans, antibodies are classified into five different classes: IgA, IgD, IgE, IgG and IgM. Most of the therapeutic mabs used in the clinic belong to the IgG class, albeit other antibody classes, e.g., IgM, have been evaluated in clinical stages. Antibodies are composed of heavy chains paired with a light chain. In IgM and IgA, an additional chain, the J-chain, is present. Two types of light chains exist in humans: the κ-light chain and the λ-light chain. The κ-light chain predominates

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Fasullo, F. J., H. A. Fritsche, F. J. Liu, and R. G. Hamilton. "IgG heavy-chain subclass typing of myeloma paraproteins by isoelectric focusing immunoblot analysis." Clinical Chemistry 35, no. 3 (1989): 364–68. http://dx.doi.org/10.1093/clinchem/35.3.364.

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Abstract The objective of this study was to develop a clinical laboratory method for subclass typing of human immunoglobulin G (IgG) paraproteins. Serum proteins were isoelectrically focused (IEF) in a mini-gel and passively blotted by capillary diffusion onto untreated nitrocellulose. Unreacted sites on the nitrocellulose were blocked with bovine serum albumin and the bound IgG was detected with peroxidase-conjugated anti-human IgG1-4 monoclonal antibodies from WHO/IUIS clones. The IEF immunoblot specificity was demonstrated by analysis of documented IgG, IgA, and IgM myeloma proteins of know

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Preston, Michael J., A. Alev Gerçeker, Mitchell E. Reff, and Gerald B. Pier. "Production and Characterization of a Set of Mouse-Human Chimeric Immunoglobulin G (IgG) Subclass and IgA Monoclonal Antibodies with Identical Variable Regions Specific forPseudomonas aeruginosa Serogroup O6 Lipopolysaccharide." Infection and Immunity 66, no. 9 (1998): 4137–42. http://dx.doi.org/10.1128/iai.66.9.4137-4142.1998.

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ABSTRACT The heavy- and light-chain variable regions from a murine monoclonal antibody that recognize Pseudomonas aeruginosaserogroup O6 lipopolysaccharide (LPS) were used to generate a series of chimeric mouse-human monoclonal antibodies with identical variable regions. The murine variable-region gene segments were cloned into an immunoglobulin (Ig) cDNA expression vector that contained the human kappa light-chain and IgG1 constant regions. The IgG1 heavy-chain constant region was then replaced with the human IgG2, IgG3, IgG4, or IgA1 heavy-chain constant region. The five different expression

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Biederman, Laura, Anjali A. Satoskar, Mohankumar Doraiswamy, et al. "Can Antinuclear Antibodies (ANA) be Monoclonal?" Case Reports in Nephrology 2021 (September 30, 2021): 1–6. http://dx.doi.org/10.1155/2021/7006466.

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Background. Nuclear staining by immunofluorescence in a kidney biopsy is often seen in patients with positive antinuclear antibodies (ANA) in the serum. These ANA are usually polyclonal, but herein we report 9 cases with an unusual finding of monoclonal nuclear staining by immunofluorescence on kidney biopsy. Case Presentation. Nine cases with predominant stain for kappa or lambda light chain were identified by searching the renal pathology laboratory database for the past 10 years. All cases had positive stain for only kappa (six cases) or lambda (three cases) light chain in the nuclei. Eight

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Daley, L. P., M. A. Kutzler, B. W. Bennett, M. C. Smith, A. L. Glaser, and J. A. Appleton. "Effector Functions of Camelid Heavy-Chain Antibodies in Immunity to West Nile Virus." Clinical and Vaccine Immunology 17, no. 2 (2009): 239–46. http://dx.doi.org/10.1128/cvi.00421-09.

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ABSTRACT Three classes of IgG have been described for camelids. IgG1 has a conventional four-chain structure, while IgG2 and IgG3 do not incorporate light chains. The structures and antigen-binding affinities of the so-called heavy-chain classes have been studied in detail; however, their regulation and effector functions are largely undefined. The aim of this study was to examine the participation of conventional and heavy-chain IgG antibodies in the camelid immune defense directed against West Nile virus (WNV). We found that natural infection or vaccination with killed WNV induced IgG1 and I

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Daley, L. P., L. F. Gagliardo, M. S. Duffy, M. C. Smith, and J. A. Appleton. "Application of Monoclonal Antibodies in Functional and Comparative Investigations of Heavy-Chain Immunoglobulins in New World Camelids." Clinical Diagnostic Laboratory Immunology 12, no. 3 (2005): 380–86. http://dx.doi.org/10.1128/cdli.12.3.380-386.2005.

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ABSTRACT Of the three immunoglobulin G (IgG) isotypes described to occur in camelids, IgG2 and IgG3 are distinct in that they do not incorporate light chains. These heavy-chain antibodies (HCAbs) constitute approximately 50% of the IgG in llama serum and as much as 75% of the IgG in camel serum. We have produced isotype-specific mouse monoclonal antibodies (MAbs) in order to investigate the roles of HCAbs in camelid immunity. Seventeen stable hybridomas were cloned, and three MAbs that were specific for epitopes on the γ chains of llama IgG1, IgG2, or IgG3 were characterized in detail. Affinit

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Flotte, T. J., and L. G. Baird. "Immunoglobulin light and heavy chain isotypes in skin diseases: restricted distribution in bullous pemphigoid and linear IgA bullous dermatosis." Journal of Immunology 136, no. 2 (1986): 491–96. http://dx.doi.org/10.4049/jimmunol.136.2.491.

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Abstract To assess the heterogeneity of immunoglobulins involved in various skin diseases, direct and indirect immunofluorescence studies of skin biopsies and sera, respectively, for kappa and lambda light chains, were performed. The anti-basement membrane zone (anti-BMZ) antibodies of patients with bullous pemphigoid showed a predominance of kappa light chains, and patients with linear IgA bullous dermatosis showed a predominance of one light chain that was sometimes kappa and sometimes lambda. The bullous pemphigoid autoantibodies were then studied for IgG subclass distribution; a predominan

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Rizk, Dana V., Lea Novak, Stacy D. Hall, et al. "Colocalization of IgG and IgA Heavy Chains with Kappa and Lambda Light Chains in Glomerular Deposits of IgA Nephropathy Patients Using High-Resolution Confocal Microscopy and Correlation with Oxford MEST-C Scores." Journal of Clinical Medicine 12, no. 23 (2023): 7361. http://dx.doi.org/10.3390/jcm12237361.

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Routine immunofluorescence microscopy of glomerular immunodeposits in IgA nephropathy shows IgA, C3, and lambda light chains, and sometimes IgG, IgM, and kappa light chains. However, a previous study using high-resolution confocal microscopy showed IgG in all IgA nephropathy cases, likely representing autoantibodies specific for galactose-deficient IgA1. Here, we used high-resolution confocal microscopy to examine the composition of glomerular immunodeposits and colocalization of kappa and lambda light chains with IgA or IgG heavy chains in kidney-biopsy samples from twenty patients with IgA n

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Herkner, K. R., H. Salzer, A. Böck, et al. "Pediatric and Perinatal Reference Intervals for Immunoglobulin Light Chains Kappa and Lambda." Clinical Chemistry 38, no. 4 (1992): 548–50. http://dx.doi.org/10.1093/clinchem/38.4.548.

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Abstract In routine analysis for immunoglobulin light chains in pediatric diagnostics, the age-related reference intervals for serum kappa (kappa) and lambda (lambda) light chains were evaluated in 1543 healthy subjects (newborns to age 16 years, including 168 premature infants). Light-chain analysis was performed by rate nephelometry. IgG, IgA, and IgM were measured simultaneously, and heavy- and light-chain differences were calculated for control purposes. Results for IgG, IgA, and IgM generally agreed with reference intervals reported in the literature. kappa showed age-related changes comp

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Rubin, R. L., F. L. Tang, A. H. Lucas, H. L. Spiegelberg, and E. M. Tan. "IgG subclasses of anti-tetanus toxoid antibodies in adult and newborn normal subjects and in patients with systemic lupus erythematosus, Sjogren's syndrome, and drug-induced autoimmunity." Journal of Immunology 137, no. 8 (1986): 2522–27. http://dx.doi.org/10.4049/jimmunol.137.8.2522.

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Abstract The IgG subclasses of anti-tetanus toxoid (anti-TT) antibodies were quantitated in normal sera and sera from patients with rheumatic disease. Detection relied on a set of four mouse monoclonal antibodies, each of which showed specificity for the respective isotype, independent of gamma-chain allotype or light chain class of the human antibody. Approximately 90% of the total anti-TT activity in normal adults and patients with Sjogren's syndrome was IgG1. In addition, IgG4 antibodies were detected in one-half the samples, but IgG2 and IgG3 antibodies were observed in only two out of 36

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Dissertations / Theses on the topic "Light chain IgG"

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Aboelhassan, Dalia Verfasser], Claus-Peter [Akademischer Betreuer] [Czerny, Sven [Akademischer Betreuer] König та Gabriele [Akademischer Betreuer] Hörstgen-Schwark. "Detection of new allotypic variants of bovine antibody λ-light chain and IgG-heavy chain constant regions / Dalia Aboelhassan. Gutachter: Claus-Peter Czerny ; Sven König ; Gabriele Hörstgen-Schwark. Betreuer: Claus-Peter Czerny". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1043765468/34.

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Sternke-Hoffmann, Rebecca [Verfasser], Alexander [Gutachter] Büll, and Rainer [Gutachter] Haas. "Looking for a white cat in a snowstorm - In depth thermodynamic and aggregation fingerprinting of patient-derived IgG light chains / Rebecca Sternke-Hoffmann ; Gutachter: Alexander Büll, Rainer Haas." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1231075023/34.

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LE, LARD-KEIL ANDREA. "Etude de la structure primaire et secondaire d'un anticorps monoclonal humain anti-d." Paris 6, 1988. http://www.theses.fr/1988PA066358.

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Determination de la sequence en amino acide de l'anticorps monoclonal humain f5 dirige contre l'antigene d du systeme rhesus (rh). La sequence a permi une etude comparative avec d'autres anticorps de sequence deja connue. Une structure secondaire probable a pu etre etablie grace a des methodes de prediction de structure

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Aboelhassan, Dalia. "Detection of new allotypic variants of bovine antibody λ-light chain and IgG-heavy chain constant regions". Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-0006-AB45-2.

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Weng, Yu-Chen, and 翁宇辰. "Application and expression of anti-nervous necrosis virus mouse immunoglobulin G (IgG) heavy chain and light chain recombinant protein in E. coli expression system." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/k4pwzq.

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碩士<br>輔仁大學<br>生命科學系碩士班<br>98<br>Abstract Groupers are the sub-tropical and tropical fish. The importance of cultivation in Taiwan and Southeast Asia is tremendous. The groupers is fresh and delicious and the production is increasing year by year yet short in supply.Due to the high density of cultivation methods, it has led to the existence and spread of some diseases. In recent years, marine fish nervous necrosis virus has been identified as one of the most severe virus to the infantile fish. In 1986, viral nervous necrosis disease was first discovered on the Oplegnathus fasciatus of Nagasaki

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Wößner, Sylvie [Verfasser]. "The influence of Igκ [Ig-kappa] locus genomic sequences on RS recombination and immunoglobulin light chain isotype expression / vorgelegt von Sylvie Wößner". 2009. http://d-nb.info/997326506/34.

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Sarna, Caitlin S. "Cloning and characterization of novel IgA antibody variable heavy and light chains from HIV-1 resistant sex workers from Nairobi, Kenya." 2011. http://hdl.handle.net/1993/4589.

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Heterosexual intercourse now accounts for the majority of HIV transmission within sub-Saharan Africa. The generation of microbicides and vaccines, therefore, requires a better understanding of the mucosal correlates of protection, including the role of HIV-specific IgA. It is now accepted that not all individuals are equally susceptible to HIV-1 infection, as exemplified by the HIV Exposed Seronegative (HESN) women of the Pumwani Cohort in Nairobi, Kenya. To assess whether mucosal IgA responses contribute to this protection, 3 novel IgA variable genes were cloned from HESN cervical B-cell

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Books on the topic "Light chain IgG"

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Centers for Disease Control (U.S.), ed. Affinity purified goat anti-human IgG (heavy and light chains) peroxidase conjugated. Centers for Disease Control, 1986.

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Purdue, Mark P., Jonathan N. Hofmann, Elizabeth E. Brown, and Celine M. Vachon. Multiple Myeloma. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0041.

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Multiple myeloma (MM) is the most common malignancy arising from plasma cells, fully differentiated B lymphocytes that produce the immunoglobulin (Ig) heavy- and light-chain molecules comprising antibodies. MM is characterized by an overproduction of clonal plasma cells in the bone marrow and, in most cases, monoclonal secretion of IgG, IgA, or light-chain Ig. Symptoms of end organ damage (hypercalcemia [C], renal failure [R], anemia [A], or bone lesions [B]), herein referred to as CRAB features, were traditionally a necessary criterion for diagnosing MM; however, improvements in treatment and

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Book chapters on the topic "Light chain IgG"

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Sindic, C. J. M. "The detection of IgA, IgM and free light chains abnormalities in cerebrospinal fluid." In Cerebrospinal Fluid Analysis in Multiple Sclerosis. Springer Milan, 1996. http://dx.doi.org/10.1007/978-88-470-2205-8_4.

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Hilyard, Kate L., David Staunton, Alison E. Jones,, and Anthony R. Rees. "Protein Engineering of Antibody Combining Sites." In Protein Engineering. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780199631391.003.0011.

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Abstract 1. Introduction The immunoglobulin G (IgG) molecule consists of a tetramer of two identical 25 kDa polypeptides (the light chain, L) and two identical 50 kDa polypeptides (the heavy chain, H). Crystal structures of IgG and IgG fragments have shown the antibody combining site (ACS) to be formed by the juxtaposition of six hypervariable loops or complementarity determining regions (CDRs), three from the light chain variable domain and three from the heavy chain variable domain. The CDRs of each chain are supported on a framework region which consists of conserved 13-strands that fold to

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Leger*, Olivier J. P., and Jose w. Saldanhat. "Preparation of recombinant antibodies from immune rodent spleens and the design of their humanization by CDR grafting." In Monoclonal Antibodies. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780199637232.003.0002.

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Abstract The biotechnological generation of high affinity monoclonal antibodies has traditionally involved the production of hybridomas from spleen cells of immunized animals. Recent advances in recombinant technology, using phage dis play technology, have opened a new route for the generation of antibodies. Instead of immortalizing B cells for production of monoclonal antibodies, the antibody heavy (H) and light (L) chain V genes are immortalized by gene technology. The IgG mRNA of B cells of immunized animals can be used as a source of variable region (V) gene libraries. Murine VH and VL gen

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Segelmark, Mårten, and Thomas Hellmark. "Antiglomerular basement membrane disease." In Oxford Textbook of Medicine, 6th ed. Oxford University PressOxford, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0488_update_001.

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Abstract Antiglomerular basement membrane (anti-GBM) disease, also known as Goodpasture’s disease, is a rare autoimmune kidney and/or lung disease typically caused by autoantibodies directed against the noncollagenous, C-terminal domain of the α3 chain of type IV collagen (α3(IV)NC1). Epidemiology—bimodal age distribution with peaks in the third and sixth/seventh decades; incidence 0.5 to 2/million population/year. Clinical features—typically presents with isolated, rapidly progressive glomerulonephritis but can also present as a renopulmonary syndrome with the combination of glomerulonephriti

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Segelmark, Mårten, and Thomas Hellmark. "Antiglomerular basement membrane disease." In Oxford Textbook of Medicine, edited by John D. Firth. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0488.

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Antiglomerular basement membrane (anti-GBM) disease, also known as Goodpasture’s disease, is a rare autoimmune kidney and/or lung disease caused by autoantibodies directed against the noncollagenous, C-terminal domain of the α‎3 chain of type IV collagen (α‎3(IV)NC1). Epidemiology—bimodal age distribution with peaks in the third and sixth/seventh decades; incidence 0.5 to 2/million population/year. Clinical features—typically presents as a renopulmonary syndrome with the combination of rapidly progressive glomerulonephritis and lung haemorrhage, but can present with isolated glomerulonephritis

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Reilly, Eric, and Larry Manders. "Immunoglobulin E (IgE) Blockers (Anti-IgE Therapy)." In Basic Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197584569.003.0250.

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Abstract Immunoglobulin E (IgE), composed of two light chains and two identical heavy chains, is a key component of many allergic diseases such as asthma. It is produced via communication between B and T cells after exposure to foreign allergens. Once produced and released, IgE can remain free in the plasma, or it can bind to membrane-bound receptors on mast cells, basophils, and other effector cells. Once bound with IgE, cells are considered sensitized. When an allergen binds to a membrane-bound IgE, the sensitized cell undergoes an activation signaling cascade which results in the release of

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Ronco, Pierre, Frank Bridoux, and Arnaud Jaccard. "Renal involvement in plasma cell dyscrasias, immunoglobulin-based amyloidoses, and fibrillary glomerulopathies, lymphomas, and leukaemias." In Oxford Textbook of Medicine, edited by John D. Firth. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0495.

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Plasma cell dyscrasias are characterized by uncontrolled proliferation of a single clone of B cells which is responsible for the secretion of a monoclonal immunoglobulin (Ig) or Ig subunit that can deposit in tissues. They can cause a wide range of renal diseases. Light-chain amyloidosis—renal presentation is usually with proteinuria, often progressing to nephrotic syndrome. A progressive decline in renal function may occur, leading finally to endstage renal failure. Diagnosis is made by the detection of monoclonal gammopathy and free light-chain excess in the serum (90% of cases), in combinat

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Ronco, P., F. Bridoux, and G. Touchard. "Renal involvement in plasma cell dyscrasias, immunoglobulin-based amyloidoses, and fibrillary glomerulopathies, lymphomas, and leukaemias." In Oxford Textbook of Medicine. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.211004_update_002.

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Plasma cell dyscrasias are characterized by uncontrolled proliferation of a single clone of B cells which is responsible for the secretion of a monoclonal immunoglobulin (Ig) or Ig subunit that can become deposited in tissues. They can cause a wide range of renal diseases. Light-chain amyloidosis—renal presentation is usually with proteinuria, often progressing to nephrotic syndrome. Progressive decline in renal function usually occurs, leading finally to endstage renal failure. Diagnosis is made by the detection of monoclonal gammopathy in serum and/or urine (90% of cases) in combination with

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Rajkumar, S. Vincent, and Robert A. Kyle. "Plasma cell myeloma and related monoclonal gammopathies." In Oxford Textbook of Medicine, edited by Chris Hatton and Deborah Hay. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0527.

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The monoclonal gammopathies, also referred to as paraproteinaemias, are a group of neoplastic (or potentially neoplastic) diseases associated with the proliferation of a single clone of immunoglobulin-secreting plasma cells. Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic clonal plasma cell disorder characterized by a serum monoclonal (M)-protein level less than 30 g/litre, less than 10% of monoclonal bone marrow plasma cells, and no evidence of hypercalcaemia, renal insufficiency, anaemia, or bone lesions related to the plasma cell proliferative process, and no ev

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MERTEN, OTTO W., MICHEL LENO, and JEAN HACHE. "QUANTITATION OF mRNA SPECIFIC FOR HEAVY AND LIGHT CHAINS OF IgG IN HYBRIDOMAS DURING DIFFERENT PHASES OF BATCH CULTURE." In Production of Biologicals from Animal Cells in Culture. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-7506-1103-9.50069-x.

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Conference papers on the topic "Light chain IgG"

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Nordfang, O., M. Ezban, and J. B. Knudsen. "IMMUNOASSAY FOR FACTOR VIII-HEAVY CHAIN. AN INDICATOR FOR IMMUNE COMPLEXES DURING HIGH DOSE FVIII INHIBITOR TREATMENT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644718.

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Specificity studies have shown that most hemophilia A inhibitor antibodies are directed towards the light chain of coagulation factor VIII (FVIII). Thus, conventional immunoassays for FVIII-antigen (FVIII:Ag) presumably have reactivity for FVIII-Light Chain (FVIII-LC) . Our sandwich FVIII :Ag assay has been shewn to be specific for only FVIII-LC. We have now developed a specific immunoassay for FVIII-Heavy Chain (FVIII-HC) . This has made it possible to investigate the FVIII-HC content in hemophilia A plasma, and to study the expression of FVIII-HC in culture medium frcm transfected cell lines

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Thompson, A. R. "ALLOANTIBODIES IN HEMOPHILIA B BINDING TO MULTIPLE FACTOR IX (IX) EPITOPES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644070.

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A high titer, boost responding inhibitor was present in a patient and his nephew, both with severe hemophilia B. On digests of their DNA, Southern blots hybridized to a cDNA were normal. They had no detectable IX antigen, including immuno-radiometric assays with a calcium-requiring polyclonal antibody fraction, in either serum or urine (less than 0.03 U/dl).Plasmas from the patient and his nephew had 12 and 25 NIH U/ml inhibitor titers, respectively. They were fractionated over IX-agarose with calcium. Unlike fractionation of rabbit polyclonal antibodies, EDTA eluates did not bind IX. Purified

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Krasnoshtanova, Alla, and Alesya Yudina. "PRODUCTION OF ANTIBODIES FROM POULTRY YOLK (IgY) AND INVESTIGATION OF THEIR IMMUNOCHEMICAL PROPERTIES." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/17.

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"A particularly important aspect of immunology is to develop non-invasive methods of obtaining antibodies which could be a great alternative to traditional ones that based on the harmful procedure of isolation of immunoglobulins from animal blood sera. That’s why the extraction of antibodies from poultry egg yolks (IgY) is the most promising. Due to the fact of variation of IgY structural features that determine the definite immunochemical properties, yolk antibodies in comparison with mammalian immunoglobulins (IgG) does not interact with rheumatoid factor (Rf), contribute to the activation o

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Senne, Carlos, Carlos Giaffer, Marcio Vega, Daiane Salomão, and Renan Domingues. "Kappa index and oligoclonal bands detection in cerebrospinal fluid samples of patients with suspected multiple sclerosis." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.741.

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Introduction: The evaluation of the intrathecal production of immunoglobulin G (IgG) can be useful in the evaluation of multiple sclerosis (MS) suspected cases and the most important test to verify it is the detection of oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) and serum. Recent studies have reported that measuring CSF IgG free light chains (FLC), especially the Kappa Index, is comparable with OCBs as markers of IgG synthesis. It is still unknown if diagnostic sensitivity be increased by performing these two methods in parallel. Objectives: The aim of this study was to evaluate th

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Moessner, Ekkehard, Thomas Hofer, Inja Waldhauer, et al. "Abstract 2955: Herceptarg, a novel heterodimeric biparatopic common light chain IgG1 antibody based on trastuzumab and pertuzumab, exerts potent anti-tumoral activity." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2955.

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Loureiro, G., LSA Rocha, DD Pereira, et al. "IMPORTÂNCIA DA QUANTIFICAÇÃO DAS CADEIAS LEVES KAPPA E LAMBDA LIVRES URINÁRIAS NO ESTUDO DAS PARAPROTEÍNAS." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.7189.

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Objetivo: Avaliar a sensibilidade e a especificidade da dosagem das CLLs por imunoturbidimetria com relação à eletroforese e à imunofixação de proteínas urinárias. Método: Trinta e oito amostras de urina da rotina laboratorial (isolada e de 24 horas) foram avaliadas. Os exames de eletroforese e imunofixação das proteínas urinárias foram solicitados. A detecção das CLLs por eletroforese e imunofixação foi realizada no equipamento SPIFE II (Helena, USA). A dosagem quantitativa das CLL foi realizada por método imunoturbidimétrico, utilizando um conjunto diagnóstico da marca Freelite (Binding Site

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Gopan, Gayatri, Geetha Narayanan, Sreejith G. Nair, et al. "Outcome of Treatment in Elderly Myeloma—A Single-Centre Experience." In Annual Conference of Indian Society of Medical and Paediatric Oncology (ISMPO). Thieme Medical and Scientific Publishers Pvt. Ltd., 2021. http://dx.doi.org/10.1055/s-0041-1735368.

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Abstract Introduction Multiple myeloma (MM) accounts for approximately 1% of all cancers and 10% of all hematologic malignancies. In our institution, we see around 200 patients with myeloma every year. We present our experience with multiple myeloma in the patients aged more than 60 years. Objectives This is a retrospective study of 300 newly diagnosed multiple myeloma patients above 60 years of age treated in the Department of Medical Oncology, Regional Cancer Center, Thiruvananthapuram, Kerala, India, during the period between 2014 and 2017. The medical records of the patients were studied a

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Marcovina, S., R. Coppola, M. P. Protti, C. Gelfi, and P. M. Mannucci. "EDTA-DEPENDENT MONOCLONAL ANTIBODIES TO HUMAN PROTEIN S." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644294.

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Abstract:

Splenocytes from a Balb/c mouse immunized with purified human protein S (PS) were fused with murine hybridoma cell line SP2/0-Agl4 and cultured in Iscove's medium without addition of fetal bovine serum. Hybrid supernatants were screened for the presence of specific antibodies by solid-phase ELISA and cloned by the limiting dilution technique. Pour clones, named S2, S3, S8, and S10, were selected, recloned several times, and injected intraperitoneally into Balb/c mice for the production of antibody-rich ascitic fluid. The monoclonal antibodies (Mabs), all of IgGl subclass with k light chain, we

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