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Relevant bibliographies by topics / Light chain restriction

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Academic literature on the topic 'Light chain restriction'

Author: Grafiati

Published: 7 June 2025

Last updated: 16 July 2025

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Journal articles on the topic "Light chain restriction"

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Flotte, T. J., and L. G. Baird. "Immunoglobulin light and heavy chain isotypes in skin diseases: restricted distribution in bullous pemphigoid and linear IgA bullous dermatosis." Journal of Immunology 136, no. 2 (1986): 491–96. http://dx.doi.org/10.4049/jimmunol.136.2.491.

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Abstract To assess the heterogeneity of immunoglobulins involved in various skin diseases, direct and indirect immunofluorescence studies of skin biopsies and sera, respectively, for kappa and lambda light chains, were performed. The anti-basement membrane zone (anti-BMZ) antibodies of patients with bullous pemphigoid showed a predominance of kappa light chains, and patients with linear IgA bullous dermatosis showed a predominance of one light chain that was sometimes kappa and sometimes lambda. The bullous pemphigoid autoantibodies were then studied for IgG subclass distribution; a predominan

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Ribeiro, Catarina Isabel, Ana Marta Gomes, Rute Carmo, and Ana Luís. "Membranous nephropathy with light chain restriction." Journal of Nephropathology 10, no. 1 (2020): e03-e03. http://dx.doi.org/10.34172/jnp.2021.03.

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Lopez De Pablo, Javier Carbayo. "Membranous Glomerulopathy with Light Chain Restriction." Nephrology & Renal Therapy 7, no. 3 (2021): 1–4. http://dx.doi.org/10.24966/nrt-7313/100067.

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Membranous nephropathy is considered the main cause of idiopathic nephrotic syndrome in adults. Mostly caused from the deposition of polytypic immune complexes along the subepitelial slope of the glomerular basement membrane

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D'Ardia, Angela, Valeria Ciliberti, Pio Zeppa, and Alessandro Caputo. "Observations on hematogones with light chain restriction." Leukemia Research Reports 17 (2022): 100316. http://dx.doi.org/10.1016/j.lrr.2022.100316.

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Kapur, Umesh, Kevin Barton, Raoul Fresco, David J. Leehy, and Maria M. Picken. "Expanding the Pathologic Spectrum of Immunoglobulin Light Chain Proximal Tubulopathy." Archives of Pathology & Laboratory Medicine 131, no. 9 (2007): 1368–72. http://dx.doi.org/10.5858/2007-131-1368-etpsoi.

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Abstract Context.—In plasma cell dyscrasias, involvement of the distal tubules is frequent and well characterized. In contrast, proximal tubules have only rarely been reported to show diagnostic pathology such as intracytoplasmic crystals. Objective.—To look for additional morphologic features that might be helpful in the diagnosis of proximal tubulopathy associated with an underlying plasma cell dyscrasia. Design.—We examined patients presenting with nonspecific renal symptoms who were found to have light chain restriction limited to proximal tubular epithelium by immunofluorescence. We corre

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Priyadarshini, Sarah, Debdatta Basu, Rakhee Kar, and T. Dutta. "Comparison Of Histomorphology, Angiogenesis and Proliferation in Kappa and Lambda Restricted Plasma Cell Myelomas with Its Effect on Prognosis." Journal of Complementary Medicine Research 14, no. 3 (2023): 77. http://dx.doi.org/10.5455/jcmr.2023.14.03.13.

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Aims Of the Study: To study the type of light chain restriction and correlate it with the morphological parameters, proliferation index, angiogenesis and clinical parameters. Materials And Methods: The study includes 46 cases of myeloma diagnosed over the period of five years. The histomorphological features like plasma cell morphology, percentage of plasma cells and pattern of infiltration were studied. Immunohistochemistry for kappa and lambda light chains was done. Angiogenesis was assessed by calculating the microvessel density (MVD) using anti CD34 immunohistochemistry. Proliferation was

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Wang, Yan, Suxia Wang, and Youkang Zhang. "Proximal Tubulopathy of Monotypic Immunoglobulin Light Chain Restriction." Hong Kong Journal of Nephrology 17, no. 2 (2015): S71—S72. http://dx.doi.org/10.1016/j.hkjn.2015.09.043.

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Jasani, Bharat. "Immunohistologically definable light chain restriction in autoimmune disease." Journal of Pathology 154, no. 1 (1988): 1–5. http://dx.doi.org/10.1002/path.1711540102.

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Pollard, K. Michael, Voula Toumasatos, Louise Furphy, and John Webb. "Immunohistologically definable light chain restriction in autoimmune disease." Journal of Pathology 156, no. 4 (1988): 349–51. http://dx.doi.org/10.1002/path.1711560412.

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Baylis, Christine, James Falconer-Smith, and Brian Ross. "Glomerular and tubular handling of differently charged human immunoglobulin light chains by the rat kidney." Clinical Science 74, no. 6 (1988): 639–44. http://dx.doi.org/10.1042/cs0740639.

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1. To examine the effect of charge and molecular size on the renal handling of immunoglobulin light chain, three different human light chains were purified, iodinated and characterized with regard to molecular weight and isoelectric point. The molecular weights were similar, whereas the isoelectric points ranged from markedly cationic to markedly anionic. 2. Renal handling of the light chains was determined in vivo in the Munich–Wistar rat and in vitro in the isolated perfused rat kidney. 3. Significant restriction to the transglomerular passage of all three light chains was evident in the int

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Book chapters on the topic "Light chain restriction"

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Smith, Claire A., Bharat Jasani, and E. Dillwyn Williams. "λ Light Chain Restriction in the Diffuse Thyroid Lymphoid Infiltrate in Untreated Graves’disease." In Thyroid Autoimmunity. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0945-1_49.

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Kharb, Simmi, Akshat Singh, Abhyuday Singh, and Deepa Kharb. "Techniques in Biotechnology." In Research Methodology and Project Management in Biotechnology. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815080742123010002.

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Nucleic acid absorbs UV light maximally at 260 nm owing to its bases. Thus, DNA or RNA yield can be quantified based on this principle. Restriction endonucleases (type II) are one of the most important groups of enzymes for the manipulation of DNA. They are bacterial enzymes that can cut/split DNA of any source at specific sites and were first discovered in bacteria E. coli restricting the replication of bacteriophages, by cutting the viral DNA. This led to differences in the size of restriction fragments obtained due to digestion with specific restriction enzymes. A restriction map is formulated by comparing the fragment size produced in every single digestion with those from double digests. In target amplification, the nucleic acid region around the area of interest is copied many times by in vitro methods. Polymerase Chain Reaction (PCR) is the best-known and the most widely applied of the target amplification methods. Original sample DNA is digested by a restricted endonuclease, separated by agarose electrophoresis, and transferred by agarose electrophoresis, and transferred to a solid support (Nylon or Nitrocellulose membrane) followed by selective visualization of fragments using labeled hybrid. DNA sequence has now become a routine procedure. It is the process of determination of nucleotide or base sequence of a DNA molecule/fragment. A probe is a nucleic acid whose identity is known and is used to reveal the identity or abundance of a target or sample. They are simple to prepare and are labelled with nucleotides that are radioactive, or fluorescent or have attached affinity labels. Also, by using a biotinlabelled primer, single-stranded probes can be obtained. Microarrays represent highdensity miniaturized arrays of molecular samples. The technology involves a series of probes immobilized on a glass slide as microdots, which are then hybridized with a mixture of test DNA sequences labelled with a fluorochrome.ization probes.

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Meissner, Dr Irene. "Diffuse B-cell lymphoma (primary central nervous system lymphoma[PCNSL])." In Fifty Neurologic Cases From Mayo Clinic. Oxford University PressNew York, NY, 2004. http://dx.doi.org/10.1093/oso/9780195177442.003.0037.

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Abstract The patient presented with a subacute progressive process that occurred over several months and affected cognition, multiple cranial nerves, and sympathetic, cerebellar, and pyramidal tracts, with associated imaging abnormalities. The symptoms of subtle cognitive changes, hearing loss (superimposed on known occupational hearing deficits), and multifocal white matter changes can be seen in many disorders. These include demyelinating processes, inflammatory disorders such as the microangiopathy of Susac’s syndrome (retinocochleocerebral vestibulopathy), sarcoidosis, Behçet’s syndrome, Listeria rhombencephalitis, and infiltrative tumors such as lymphoma or gliomatosis cerebri. In our patient, a brain biopsy specimen contained tumor cells positive for CD20 and CD79a, with a light chain restriction supporting the diagnosis of diffuse B-cell lymphoma (PCNSL).

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Strauchen, James A. "Mature B Cell Leukemias." In Diagnostic Histopathology of the Bone Marrow. Oxford University PressNew York, NY, 1996. http://dx.doi.org/10.1093/oso/9780195097566.003.0016.

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Abstract Mature lymphocytic leukemias are clonal proliferations of differentiated lymphoid cells that express the phenotype of mature B or T lymphocytes. The mature B cell leukemias express B cell markers and surface immunoglobulin with clonal light chain restriction. The mature T cell leukemias are much less common and will be considered separately. The French-American-British Cooperative Group has proposed a classification of the mature lymphocytic leukemias (Bennett et al, 1989). The mature B cell leukemias are divided into ten categories: (1) typical chronic lymphocytic leukemia, (2) chronic lymphocytic leukemia with pleomorphic lymphocytes, (3) chronic lymphocytic leukemia of mixed cell type with 10%-55% prolymphocytes, (4) prolymphocytic leukemia, (5) hairy cell leukemia, (6) hairy cell leukemia variant, (7) splenic lymphoma with circulating villous lymphocytes, (8) leukemic phase of non-Hodgkin’s lymphoma, (9) lymphoplasmacytic lymphoma with peripheral blood disease, and (10) plasma cell leukemia. In this chapter, chronic lymphocytic leukemia and its variants---prolymphocytic leukemia, hairy cell leukemia, splenic lymphoma with circulating villous lymphocytes, and leukemic phase of non-Hodgkin’s lymphoma-will be considered. Lymphoplasmacytic lymphoma and plasma cell leukemia are considered with the plasma cell disorders in Chapter 21. Chronic lymphocytic leukemia is a clonal proliferation of small mature B lymphocytes of characteristic phenotype involving the blood and bone marrow.

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Strickler, Eva, Ernest Tsiaze, Gerrit Hellige, Dominik Zumstein, Dominik Waldmeier, and Nisha Arenja. "Diagnosis of Cardiac Amyloidosis Using Non-Invasive Technics." In Amyloidosis History and Perspectives [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97263.

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Amyloidosis is a rare multiorgan disease defined by a process of irreversible, extracellular accumulation of fibrillar proteins in the tissues, including the heart. Cardiac involvement is seen in most forms of amyloidosis, but it is frequently present and clinically significant in light chain (AL)-amyloidosis as well as transthyretin amyloidosis (ATTR). Cardiac amyloid accumulation leads to a restrictive filling pattern, which must be differentiated from other forms of restrictive and hypertrophic cardiomyopathies due to consequences for the treatment. Evolving knowledge of the disease has led to a definite diagnosis of the cardiac amyloidosis (CA) using non-invasive and low-risk diagnostic features, such as scintigraphy (gamma scan) and cardiovascular magnetic resonance (CMR) imaging using late gadolinium enhancement (LGE) and T1 mapping technics. The availability and diagnostic accuracy of these technics has reduced the need for cardiac biopsy. In the following chapter, we will describe common types of CA, the basic concepts, and updates of non-invasive diagnostic features.

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Andrea Eötvös, Csilla, Giorgia Pastiu, Iulia Zehan, et al. "Cardiac Amyloidosis." In Cardiomyopathy - Disease of the Heart Muscle [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97129.

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Amyloidosis represents a heterogeneous group of disorders caused by amyloid fibril deposition in the extracellular space in different organs. Among the many types of amyloidosis cardiac involvement occurs almost exclusively with immunoglobulin light chain amyloidosis (AL amyloidosis) or transthyretin amyloidosis (ATTR amyloidosis). When present cardiac amyloidosis (CA) has a significant impact on disease prognosis. The typical clinical presentation in CA is that of a restrictive cardiomyopathy. Clinical suspicion of CA is based on clinical, laboratory and electrocardiographic findings. The diagnosis is confirmed using echocardiography, cardiac magnetic resonance imaging, biopsy, and/or bone scintigraphy. A precise definition of amyloidosis type is essential for choosing the specific treatment for this condition. Treatment of CA has two components: general treatment of congestive HF, and specific treatment of the underlying protein misfolding disorder.

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Conference papers on the topic "Light chain restriction"

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Chung, D. W., R. Asakai, and E. W. Davie. "THE ORGANIZATION OF THE HUMAN FACTOR XI GENE: CORRELATION OF INTRON AND EXON LOCATIONS WITH STRUCTURAL DOMAINS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642802.

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Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein that participates in the contact activation of blood coagulation. In the present study, the organization of the gene for human factor XI has been elucidated. The gene for human factor XI has been isolated from two independent human genomic λ phage libraries using a full length cDNA for human factor XI as a hybridization probe. Four overlapping recombinant λ phage containing the human factor XI gene have been isolated and characterized. Restriction mapping, Southern blotting and hybridization studies indicate that the entire

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Corona, Georgina, Ryan Novelen, Stephen Greci, et al. "Innovative Density-Based Autonomous Inflow Control Technology to Enhance Well Performance." In SPE Conference at Oman Petroleum & Energy Show. SPE, 2025. https://doi.org/10.2118/224853-ms.

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Abstract Inflow control technology balances production flow across a completion to delay unwanted fluid breakthrough and enhance well performance. Nevertheless, ICDs and viscosity-based AICDs have limited capabilities in identifying and restricting unwanted fluids upon breakthrough in light oil reservoirs due to the similar viscosity between oil and water. This paper describes an autonomous inflow control device that allows or impedes flow based on fluid density. It also presents its qualification testing and carbon intensity reduction estimations. By relying on the density contrast between oi

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Pracht, P., P. Minotti, and M. Dahan. "Synthesis and Balancing of Cam-Modulated Linkages." In ASME 1987 Design Technology Conferences. American Society of Mechanical Engineers, 1987. http://dx.doi.org/10.1115/detc1987-0083.

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Abstract Linkages are inherently light, inexpensive, strong, adaptable to high speeds and have little friction. Moreover the class of functions suitable for linkage representation is large. For all these reasons numerous recent works deal with the problem of design mechanisms for robotic applications, but very often in terms of components such as gripper, transmission, balancing. We investigate a new application for linkages, using them to design industrial manipulator. The selected mechanism for this application is a four bar linkage with an adjustable lengh for exact path generation. This ad

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Calle-Asensio, Alejandro, Juan José Hernández, José Rodríguez-Fernández, and Víctor Domínguez-Pérez. "Effect of Butanol on the Performance of DeNOx Aftertreatment Systems of a Diesel Vehicle Under WLTC Driving Conditions." In ASME 2021 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/icef2021-67337.

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Abstract Advanced biofuels and electrofuels, among which are medium-long chain alcohols, have gained importance in the transport sector with the enforcement of the EU Renewable Energy Directive (2018/2001). In parallel, last European emission regulations have become much more restrictive regarding NOx, so vehicle manufacturers have been forced to incorporate lean NOx trap (LNT) and/or selective catalytic reduction (SCR). Thus, the combination of modern DeNOx devices and the upcoming higher contribution of sustainable biofuels is a new challenge. In this work, two Euro 6 diesel vehicles, one eq

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Gershenson, J. K., B. D. Solomon, D. R. Shonnard, D. W. Watkins, and J. W. Sutherland. "Production Decision Making in the Face of Uncertainty About Air Toxics Regulation and Global Climate Change Policy." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/ts-23414.

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Abstract There is an urgent need to better understand and quantify firm-level decisions made in response to environmental policy. It is to be expected that in the face of new/stricter regulations (e.g., tightened regulations relating to airborne particulate emissions) that the desired intent of the regulation will be achieved (e.g., reduced large-plant emissions in the U.S.). However, the secondary environmental and economic impacts of these policies/regulations are poorly understood. These secondary effects, those beyond the primary environmental effects intended by the policy and what is nor

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Cunningham, Violet, Alexander Tilton, Dylon Maertens, and Shawn Duan. "Innovative Design of Indoor-Outdoor Powerchair." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-23497.

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Abstract People with disabilities often struggle with mobility issues, so there is a strong desire for devices such as powerchairs, which can provide more freedom. Currently, wheelchair demand in the US is increasing due to an upsurge in the elderly population. Often electric powerchairs suitable for outdoor use are extremely expensive, cannot be used indoors, and are not covered by medical insurance. In this project, these problems are addressed through the design of a chair which is suitable for both rough outdoor terrain and indoor use. This project is based on a request for a powerchair wh

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Mansour, M., G. Kocer, C. Lenherr, N. Chokani, and R. S. Abhari. "Full Scale Wind Turbine Flowfield Measurements Using a 7-Sensor Fast Response Probe." In ASME Turbo Expo 2010: Power for Land, Sea, and Air. ASMEDC, 2010. http://dx.doi.org/10.1115/gt2010-23425.

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The unsteady wind profile in the atmospheric boundary layer upstream of a modern wind turbine is measured. The measurements are accomplished using a novel measurement approach that is developed and demonstrated for wind energy applications. The measurements of the unsteady 3D velocity field have to be resolved in a low dynamic head environment and over large flow angles around a modern wind turbine (rotor diameter 80–120m and tower height 60–100m). The novel measurement approach is comprised of an autonomous Uninhabited Aerial Vehicle (UAV) that is equipped with a seven-sensor fast-response ae

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Ananchenkova, Polina, and Elena Ponomareva. "IMPLEMENTATION OF DISTANCE LEARNING TECHNOLOGIES IN THE EDUCATION PROCESS: ORGANIZATIONAL, MOETHODOLOGICAL, HUMAN RESOURCES AND TECHNOLOGICAL SUPPORT ISSUES." In eLSE 2016. Carol I National Defence University Publishing House, 2016. http://dx.doi.org/10.12753/2066-026x-16-159.

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Russian higher vocational education system is currently undergoing a reform, with joining the Bologna process, implementing dual-level education system (Bachelor's degree, Master's degree), moving to new federal state education standards, implementing a competency-based approach - all these institutional transformations shape the reforms and content of education process in higher learning institutions. Classical form of education, with in-class learning (lectures and seminars), independent work, tests and exams, is becoming less efficient in terms of building professional knowledge and skills.

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