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Journal articles on the topic 'Light for bipolar disease'

Author: Grafiati

Published: 25 June 2021

Last updated: 29 July 2025

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1

Fatemi, S. Hossein, Teri J. Reutiman, and Timothy D. Folsom. "The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder." Biochemical Society Transactions 37, no. 5 (2009): 1090–95. http://dx.doi.org/10.1042/bst0371090.

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Bipolar disorder is a debilitating disorder of the brain with a lifetime prevalence of 1.0% for bipolar I, 1.1% for bipolar II disorder and 2.4–4.7% for subthreshold bipolar disorder. Medications, including lithium, have demonstrated efficacy in the treatment of bipolar disorder, but their molecular targets and mode of action are largely unknown. A few studies have begun to shed light on potential targets of lithium treatment that may be involved in lithium's therapeutic effect. We have recently conducted a microarray study of rat frontal cortex following chronic treatment (21 days) with lithi

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Xiao, Kunbo. "Bipolar Disorder in Adolescents: Early Detection and Intervention Strategies." Journal of Education, Humanities and Social Sciences 26 (March 2, 2024): 681–85. http://dx.doi.org/10.54097/k8ydwg47.

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As a severe mental condition marked by extreme mood swings, with the development of science and technology, adolescent bipolar disorder’s detection and therapy have been increasingly valued by research workers. This article explores the complex issue of adolescent bipolar disorder, highlighting the part played by genetic predisposition and neurological factors in determining how the condition develops, providing directions for further study and likely targeted treatments with a literature review approach. Meanwhile, this review highlights the crucial need for early detection and therapeutic te

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McClements, Michelle E., Federica Staurenghi, Meike Visel, John G. Flannery, Robert E. MacLaren, and Jasmina Cehajic-Kapetanovic. "AAV Induced Expression of Human Rod and Cone Opsin in Bipolar Cells of a Mouse Model of Retinal Degeneration." BioMed Research International 2021 (February 9, 2021): 1–8. http://dx.doi.org/10.1155/2021/4014797.

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Vision loss caused by inherited retinal degeneration affects millions of people worldwide, and clinical trials involving gene supplementation strategies are ongoing for select forms of the disease. When early therapeutic intervention is not possible and patients suffer complete loss of their photoreceptor cells, there is an opportunity for vision restoration techniques, including optogenetic therapy. This therapy provides expression of light-sensitive molecules to surviving cell types of the retina, enabling light perception through residual neuronal pathways. To this end, the bipolar cells ma

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Kolind, Mikkel EI, Rikke Kruse, Anni S. Petersen, et al. "Investigating the role of obesity, circadian disturbances and lifestyle factors in people with schizophrenia and bipolar disorder: Study protocol for the SOMBER trial." PLOS ONE 19, no. 7 (2024): e0306408. http://dx.doi.org/10.1371/journal.pone.0306408.

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The aim of this study is to investigate circadian rhythms in independently living adults with obesity and mental disease, exploring the interplay between biological markers and lifestyle factors. Eighty participants divided equally into four groups; (i) people with obesity and schizophrenia; (ii) people with obesity and bipolar disorder; (iii) people with obesity without mental disease or sleep disorders, and (iv) people without obesity, mental disease or sleep disorders. Over two consecutive days, participants engage in repeated self-sampling of hair follicle and saliva; concurrently, data is

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Notov, I. K., S. V. Zalavina, S. V. Mashak, et al. "Comparative assessment of structural changes in the prostate after bipolar plasma and thulium fiber laser enucleation of benign prostatic hyperplasia." Acta Biomedica Scientifica 9, no. 2 (2024): 130–40. http://dx.doi.org/10.29413/abs.2024-9.2.13.

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Background. Benign prostatic hyperplasia (BPH) is a common disease in older men. Transurethral surgery in BPH is the gold standard for treatment, but the techniques differ in the energy used. Considering the different mechanisms of action of bipolar plasma and thulium fiber laser energy on prostate tissue, the study of structural changes under their influence is relevant.The aim. To study the features of structural changes in the prostate during bipolar plasma and thulium fiber laser enucleation of benign prostatic hyperplasia.Methods. Thirty one patients with BPH were divided into two groups.

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Squitti, Rosanna, Antonio Fiorenza, Alessandra Martinelli, et al. "Neurofilament Light Protein as a Biomarker in Severe Mental Disorders: A Systematic Review." International Journal of Molecular Sciences 26, no. 1 (2024): 61. https://doi.org/10.3390/ijms26010061.

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Severe mental disorders (SMDs), such as schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD), are heterogeneous psychiatric diseases that impose a significant societal burden due to their chronic disabling nature. There are no objective and reliable diagnostic tests for SMDs; thus, there is an urgent need for specific biomarkers to improve diagnosis, treatment, and resource allocation. Neurofilaments, found in cerebrospinal fluid and blood, offer reliable diagnostic and prognostic potential. This review discusses the link between neurofilament light chain (NfL) involv

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Fujimura, Toshimasa, Daiki Taira, Yoshihiro Uchida, et al. "Factors associated with self-perceived treatment-resistance in bipolar disorder." Medicine 103, no. 1 (2024): e36217. http://dx.doi.org/10.1097/md.0000000000036217.

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Patients with bipolar disorder often report self-perceived treatment resistance. However, it is not known to what extent it is due to actual treatment resistance. The Juntendo University provides “Bipolar Disorder Treatment Rebuilding Program,” in which patients with self-reported treatment resistant bipolar disorder are hospitalized for 2 weeks and undergo detailed examinations. In this study, we report our experience with the initial 43 patients hospitalized during the one and half years after the launch of the program. Among the patients who underwent full assessment, only one was regarded

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Bilal, Muhammad, Maria Shahzadi, and Muhammad Sikander Ghayas Khan. "Electroretinography - An Evolving Technique for Early Detection of Retinal Dysfunction." Pakistan Journal of Medical and Health Sciences 16, no. 12 (2022): 1–2. http://dx.doi.org/10.53350/pjmhs202216121.

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Human vision comprises different structures whose physiological functions act as variable for a healthy human vision. Retina plays a vital role in vision, in hosting different cells and neuron in ten layers. The perikaryal of these neurons are segregated from neurological processes, forming discrete layers1. The inner retina includes ganglion cells and amacrine cells, whereas the outer retina includes the rod and cone photoreceptors. The primary role of photoreceptors is to convert light energy into an electrical signal (phototransduction)2. The photoreceptors transmit visual information to se

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Bilal, Muhammad, Maria Shahzadi, and Muhammad Sikander Ghayas Khan. "Electroretinography - An Evolving Technique for Early Detection of Retinal Dysfunction." Pakistan Journal of Medical and Health Sciences 16, no. 11 (2022): 1–2. http://dx.doi.org/10.53350/pjmhs202216111.

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Human vision comprises different structures whose physiological functions act as variable for a healthy human vision. Retina plays a vital role in vision, in hosting different cells and neuron in ten layers. The perikaryal of these neurons are segregated from neurological processes, forming discrete layers1. The inner retina includes ganglion cells and amacrine cells, whereas the outer retina includes the rod and cone photoreceptors. The primary role of photoreceptors is to convert light energy into an electrical signal (phototransduction)2. The photoreceptors transmit visual information to se

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10

Park, MiYoun, JiYoung Ahn, YeonJin Choi, MyeungNam Kim, and JungYeon Lee. "The safety and efficacy of a combined diode laser and bipolar radiofrequency compared with combined infrared light and bipolar radiofrequency for skin rejuvenation." Indian Journal of Dermatology, Venereology, and Leprology 78, no. 2 (2012): 146. http://dx.doi.org/10.4103/0378-6323.93630.

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Kralik, Jakub, and Sonja Kleinlogel. "Functional Availability of ON-Bipolar Cells in the Degenerated Retina: Timing and Longevity of an Optogenetic Gene Therapy." International Journal of Molecular Sciences 22, no. 21 (2021): 11515. http://dx.doi.org/10.3390/ijms222111515.

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Degenerative diseases of the retina are responsible for the death of photoreceptors and subsequent loss of vision in patients. Nevertheless, the inner retinal layers remain intact over an extended period of time, enabling the restoration of light sensitivity in blind retinas via the expression of optogenetic tools in the remaining retinal cells. The chimeric Opto-mGluR6 protein represents such a tool. With exclusive ON-bipolar cell expression, it combines the light-sensitive domains of melanopsin and the intracellular domains of the metabotropic glutamate receptor 6 (mGluR6), which naturally m

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Firsov, M. L. "Retinal electronic prostheses." Сенсорные системы 37, no. 3 (2023): 205–17. http://dx.doi.org/10.31857/s0235009223030046.

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Electronic retinal implants are a promising technology for partially restoring vision after severe neurodegenerative diseases. The basic idea is to replace damaged photoreceptors with electronic devices that convert light signals into electrical impulses stimulating bipolar or ganglion cells in the retina. In this review, we will look at the history of this technology, the current state of the art, and the different designs and operating principles of retinal implants.

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Goo, Hyeyoon, Min Young Lee, Yea-Jin Lee, Sangkeun Lee, Jin-Chul Ahn, and Namgue Hong. "Multi-Wavelength Photobiomodulation Ameliorates Sodium Iodate-Induced Age-Related Macular Degeneration in Rats." International Journal of Molecular Sciences 24, no. 24 (2023): 17394. http://dx.doi.org/10.3390/ijms242417394.

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Age-related macular degeneration (AMD) is a global health challenge. AMD causes visual impairment and blindness, particularly in older individuals. This multifaceted disease progresses through various stages, from asymptomatic dry to advanced wet AMD, driven by various factors including inflammation and oxidative stress. Current treatments are effective mainly for wet AMD; the therapeutic options for dry AMD are limited. Photobiomodulation (PBM) using low-energy light in the red-to-near-infrared range is a promising treatment for retinal diseases. This study investigated the effects of multi-w

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Wadhwa, Ridhima, Riya Gupta, and Pawan K. Maurya. "Oxidative Stress and Accelerated Aging in Neurodegenerative and Neuropsychiatric Disorder." Current Pharmaceutical Design 24, no. 40 (2019): 4711–25. http://dx.doi.org/10.2174/1381612825666190115121018.

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Background: Neurodegenerative diseases are becoming more and more common in today’s world. As people are continuously being exposed to exogenous factors like UV radiations, gamma rays, X-Rays, environmental pollutants and heavy metals, the cases of increased oxidative damage are increasing. Even though some amount of oxidative damage occurs in all metabolic reactions but their increase from the normal level in organisms causes neurodegenerative diseases. These neurodegenerative disorders like Alzeimers, Parkinsons disease and neuropsychiatric disorders such as schizophrenia, bipolar, depressio

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Dianga, Lawrence, Mathew Madu, Alana Durrant, Leia Penfold, and Joanna Pepper. "A Case Series Highlighting Complexities in the Management of Bipolar Disorder With Parkinson’s Disease." BJPsych Open 11, S1 (2025): S298. https://doi.org/10.1192/bjo.2025.10719.

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Aims: Evidence is emerging regarding the association between Bipolar Affective Disorder (BPAD) and Parkinson’s disease (PD). Studies have shown patients with BPAD have a higher risk of developing PD. This case series explores the complexities encountered in the management of patients with PD and BPAD.Methods: ‘A’ is a woman in her 70s with BPAD. Parkinsonian symptoms were noted for several years, suspected to be medication-induced. She was diagnosed with Parkinson’s disease, after a positive DaT scan, treated with co-beneldopa, which induced a manic episode, requiring hospitalization. Co-benel

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Cabra Lopez, Jose-Luis, Carlos Parra, Libardo Gomez, and Luis Trujillo. "Sex Recognition through ECG Signals aiming toward Smartphone Authentication." Applied Sciences 12, no. 13 (2022): 6573. http://dx.doi.org/10.3390/app12136573.

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Physiological signals are strongly related to a person’s state of health and carry information about the human body. For example, by ECG, it is possible to obtain information about cardiac disease, emotions, personal identification, and the sex of a person, among others. This paper proposes the study of the heartbeat from a soft-biometric perspective to be applied to smartphone unlocking services. We employ the user heartbeat to classify the individual by sex (male, female) with the use of Deep Learning, reaching an accuracy of 94.4% ± 2.0%. This result was obtained with the RGB representation

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Vincent, Ajoy, Kashif Ahmed, Rowaida Hussein, et al. "Retinal Phenotyping of a Murine Model of Lafora Disease." Genes 14, no. 4 (2023): 854. http://dx.doi.org/10.3390/genes14040854.

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Lafora disease (LD) is a progressive neurologic disorder caused by biallelic pathogenic variants in EPM2A or EPM2B, leading to tissue accumulation of polyglucosan aggregates termed Lafora bodies (LBs). This study aimed to characterize the retinal phenotype in Epm2a−/− mice by examining knockout (KO; Epm2a−/−) and control (WT) littermates at two time points (10 and 14 months, respectively). In vivo exams included electroretinogram (ERG) testing, optical coherence tomography (OCT) and retinal photography. Ex vivo retinal testing included Periodic acid Schiff Diastase (PASD) staining, followed by

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Rudkovska, O. D. "Autism: a new approach to etiopathogenesis and treatment." Journal of Psychology & Clinical Psychiatry 16, no. 2 (2025): 62–63. https://doi.org/10.15406/jpcpy.2025.16.00812.

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Autism is considered a multifactorial disease, the trigger of which is unknown. Hypothesis of the occurrence of autism: in genetically predisposed individuals, long-term negative factors cause - through cortico-nuclear pathways - excessive constriction of the pupils, which is manifested by the activation of the parasympathetic nervous system. Constricted pupils (reduction in light flux) through the optic-vegetative system trigger pathological biochemical processes in the body, which leads to a deterioration in the mental and physical state of patients. It has been suggested that treatment for

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Schilardi, Giulia, Jakub Kralik, and Sonja Kleinlogel. "Selective Block of Upregulated Kv1.3 Potassium Channels in ON-Bipolar Cells of the Blind Retina Enhances Optogenetically Restored Signaling." International Journal of Molecular Sciences 24, no. 18 (2023): 14207. http://dx.doi.org/10.3390/ijms241814207.

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Loss of photoreceptors in retinal degenerative diseases also impacts the inner retina: bipolar cell dendrites retract, neurons rewire, and protein expression changes. ON-bipolar cells (OBCs) represent an attractive target for optogenetic vision restoration. However, the above-described maladaptations may negatively impact the quality of restored vision. To investigate this question, we employed human post-mortem retinas and transgenic rd1_Opto-mGluR6 mice expressing the optogenetic construct Opto-mGluR6 in OBCs and carrying the retinal degeneration rd1 mutation. We found significant changes in

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Carta, MG, V. Ruggiero, F. Sancassiani, et al. "The Use of Antidepressants in the Long-Term Treatment Should not Improve the Impact of Fibromyalgia on Quality of Life." Clinical Practice & Epidemiology in Mental Health 9, no. 1 (2013): 120–24. http://dx.doi.org/10.2174/1745017901309010120.

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Background: Antidepressant (AD) drugs are effective in the short term treatment of fibromyalgia (FM). It may be useful to study the long-term impact of AD on patients with FM. Methods: One-year follow-up study on 23 females with FM divided into groups on AD (ADg-N=7), and not taking AD (NADg-N=11). Evaluation at t1 and at the end (t2) with the Fibromyalgia Impact Questionnaire (FIQ); at t2 with: SCID-IV; Mood Disorder Questionnaire (MDQ); Short Form-12; Hamilton Depression Rating Scale (HAM-D); Functioning Assessment Short Test (FAST) Results: After a year the AD group showed a worst impact of

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Smith, Rachel N., Amruta S. Agharkar, and Eric B. Gonzales. "A review of creatine supplementation in age-related diseases: more than a supplement for athletes." F1000Research 3 (September 15, 2014): 222. http://dx.doi.org/10.12688/f1000research.5218.1.

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Creatine is an endogenous compound synthesized from arginine, glycine and methionine. This dietary supplement can be acquired from food sources such as meat and fish, along with athlete supplement powders. Since the majority of creatine is stored in skeletal muscle, dietary creatine supplementation has traditionally been important for athletes and bodybuilders to increase the power, strength, and mass of the skeletal muscle. However, new uses for creatine have emerged suggesting that it may be important in preventing or delaying the onset of neurodegenerative diseases associated with aging. On

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Tu, Xinhang, Victor Peng, and Jennifer So. "1043 A Rare Case of Non-24-hour Sleep-Wake Rhythm Disorder in A Sighted Patient." SLEEP 46, Supplement_1 (2023): A457—A458. http://dx.doi.org/10.1093/sleep/zsad077.1043.

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Abstract Introduction Non-24-hour sleep-wake disorder is a circadian rhythm sleep disorder which causes failure of endogenous circadian rhythm cycles to synchronize to a 24-hour day. Despite an unknown prevalence in sighted people, it's thought to be rare. We present a case of a sighted patient with concurrent bipolar disorder who presented with excessive sleepiness since preadolescence, and was later found to have N24SWD. Report of case(s) A 29 year old woman with bipolar disorder presented with excessive daytime sleepiness and irregular sleep schedule since age 12. During her teenage years s

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Wanot, Bartosz, Barbara Szczygieł, Wojciech Wanot, and Mariana Magerčiaková. "DEPRESSION - TYPES AND TREATMENT OF DEPRESSION." Scientific Journal of Polonia University 32, no. 1 (2019): 121–30. http://dx.doi.org/10.23856/3216.

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The key symptom of depression is lowering the mood, but this is not the only sign of depression. Depression is a disease in which the symptoms reach various intensities and occur in many configurations. We distinguish the following types of depression: reactive, endogenous, neurotic, anankastic, agitated, large and small, morning (subclinical and subliminal), seasonal, masked, psychotic, postpartum, drug resistant, in children and adolescents, in the elderly, involutional, organic , in bipolar disorder, dysthymia, depression and anxiety, and in somatic diseases. Psychotherapy is now a popular

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Mishma S, Vinola Shrim, and Arun Shanmugam. "The Prevalence of Psychiatric and Behavioral Comorbid Among Autistic adults." Biosciences Biotechnology Research Asia 21, no. 2 (2024): 501–7. http://dx.doi.org/10.13005/bbra/3242.

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ABSTRACT: This article aims to shed light on the co-occurrence of behavioural and mental comorbidities in people with Autism. In 1943, psychiatrist Leo Kanner coined the term "Autism." Autism is a neurodevelopmental disease known as autism spectrum disorder (ASD). The three following categories are more likely to cause difficulties for adults with Autism: Social interaction, communication, and flexibility in thought and action. Autism has long-lasting effects on a person's life. People living with ASD are more likely to have one or more co-occurring mental disorders. For people with Autism, ad

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Wang, Yi-Guang, Chih-Chung Huang, Ta-Chuan Yeh, et al. "Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study." Medicina 61, no. 3 (2025): 486. https://doi.org/10.3390/medicina61030486.

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Background and Objectives: In recent years, bipolar disorder (BD), a multifaceted mood disorder marked by severe episodic mood fluctuations, has been shown to have an impact on disability-adjusted life years (DALYs). The increasing prevalence of BD highlights the need for better diagnostic tools, particularly those involving genetic insights. Genetic association studies can play a crucial role in identifying variations linked to BD, shedding light on its genetic underpinnings and potential therapeutic targets. This study aimed to identify novel genetic variants associated with BD in the Taiwan

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Snedkov, E. V., A. E. Veraksa, and P. Y. Muchnik. "Schizoaffective disorder: the past and the future of hybrid construction." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY 56, no. 2 (2022): 8–20. http://dx.doi.org/10.31363/2313-7053-2022-56-2-8-20.

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The article argues for the discrepancy between the artificial construction of «schizoaffective disorder» (SAD) and the principles of nosological diagnostics. The term of «acute schizoaffective psychoses», was introduced by Y. Kazanin in 1933, is still remain a controversial nosological unit. This diagnosis often made at the cut of a psychotic episode on a «dichotomous scale» by «weighing» schizophrenic and affective symptoms. In the history of the creation of the concept of SAD, there is a tendency towards reductionism and the search for universal manifestations. Each individual clinical case

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Moura, Mateus T., Flávio V. Machado, Gabriela L. Martins, et al. "P14: Chronobiological assessment of stable elderly individuals with type I bipolar disorder." International Psychogeriatrics 36, S1 (2024): 126. http://dx.doi.org/10.1017/s1041610224002485.

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Objectives: Evaluate the chronobiological rhythm of elderly people with type I bipolar disorder (BD), stable and without dementia, compared to controls.Methods: A cross-sectional study was performed with 20 patients diagnosed with type I bipolar disorder, diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and 20 controls. Actigraphic records were gathered from all participants over 7 days, besides clinical and demographic information. Non-parametric chronobiological measurements were calculated to evaluate the activity-rest cycle. Comparisons betwe

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Liu, Zhuolin, Kazuhiro Kurokawa, Furu Zhang, John J. Lee, and Donald T. Miller. "Imaging and quantifying ganglion cells and other transparent neurons in the living human retina." Proceedings of the National Academy of Sciences 114, no. 48 (2017): 12803–8. http://dx.doi.org/10.1073/pnas.1711734114.

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Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human retina, GCs remain elusive due to their high optical translucency. Failure of conventional imaging—using predominately singly scattered light

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Basavaraj, K., G. S. Jasudasu, V. Prakasam, et al. "Enhanced sporulation by different light and nutritional sources in Bipolaris oryzae causing brown spot disease of rice." Journal of Environmental Biology 44, no. 3 (2023): 380–89. http://dx.doi.org/10.22438/jeb/44/3/mrn-4036.

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Aim: The present study aimed to investigate the inter-relation of different light and nutritional sources on the sporulation of fungus. Methodology: Two isolates of Bipolaris oryzae collected from IIRR, Hyderabad and Lonavala were used in the present study. These isolates were cultured on routine culture media-potato dextrose agar for five days and irradiated with different regimes of near ultraviolet (NUV), ultraviolet and visible light to assess their ability to induce sporulation in fungus. With standardized light source (exposure of fungus to NUV 12hr and 12 hr of darkness), different stre

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Oriolo, G., A. Brugués, J. M. Goikolea, and L. Pintor. "Lamotrigine induced DRESS syndrome in bipolar disorder: Multiple snares behind a potentially life-threatening adverse reaction." European Psychiatry 33, S1 (2016): S616. http://dx.doi.org/10.1016/j.eurpsy.2016.01.2304.

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BackgroundLamotrigine is widely used to prevent bipolar depression. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a rare, potentially life-threatening adverse effect. The long latency between drug exposure and disease onset, added to the high variability of its clinical presentation, can increase the risk of misdiagnosis lamotrigine withdrawal delay.ObjectiveTo highlight potential risk factors that can be related to a worse clinical onset and evolution of lamotrigine-induced DRESS syndrome.MethodsWe report the case of a 25-year-old-man, with a type I bipolar disorder, treate

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Lan, Yi-Feng Carol, Diane C. Zelman, and Wen-Tao Chao. "Angry characters and frightened souls: Patients and family explanatory models of bipolar disorder in Taiwan." Transcultural Psychiatry 55, no. 3 (2018): 317–38. http://dx.doi.org/10.1177/1363461518761924.

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Bipolar disorder (BD) affects a significant proportion of Taiwanese individuals (Weissman et al., 1996; Yang, Yeh, & Hwu, 2012). Psychotropic medications are typically the mainstay of treatment for BD, and there is an abundance of international research on biological etiology and medication options. However, there is comparatively little research on psychosocial aspects of BD, including how it is understood and managed within families. As culture provides the context in which psychiatric disease is managed, there is a need to identify distinct Chinese psychosocial perspectives that might s

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Yang, Tsai-Hsuan, Eugene Yu-Chuan Kang, Pei-Hsuan Lin, Pei-Liang Wu, Jacob Aaron Sachs, and Nan-Kai Wang. "The Value of Electroretinography in Identifying Candidate Genes for Inherited Retinal Dystrophies: A Diagnostic Guide." Diagnostics 13, no. 19 (2023): 3041. http://dx.doi.org/10.3390/diagnostics13193041.

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Inherited retinal dystrophies (IRDs) are a group of heterogeneous diseases caused by genetic mutations that specifically affect the function of the rod, cone, or bipolar cells in the retina. Electroretinography (ERG) is a diagnostic tool that measures the electrical activity of the retina in response to light stimuli, and it can help to determine the function of these cells. A normal ERG response consists of two waves, the a-wave and the b-wave, which reflect the activity of the photoreceptor cells and the bipolar and Muller cells, respectively. Despite the growing availability of next-generat

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Yurko, Ronald, Max G’Sell, Kathryn Roeder, and Bernie Devlin. "A selective inference approach for false discovery rate control using multiomics covariates yields insights into disease risk." Proceedings of the National Academy of Sciences 117, no. 26 (2020): 15028–35. http://dx.doi.org/10.1073/pnas.1918862117.

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To correct for a large number of hypothesis tests, most researchers rely on simple multiple testing corrections. Yet, new methodologies of selective inference could potentially improve power while retaining statistical guarantees, especially those that enable exploration of test statistics using auxiliary information (covariates) to weight hypothesis tests for association. We explore one such method, adaptiveP-value thresholding (AdaPT), in the framework of genome-wide association studies (GWAS) and gene expression/coexpression studies, with particular emphasis on schizophrenia (SCZ). Selected

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Mimura, Masaru. "FC19: PET imaging of late-life psychosis and mood disorder." International Psychogeriatrics 36, S1 (2024): 50. http://dx.doi.org/10.1017/s1041610224001418.

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Summary: In his 1910 textbook, 8th Edition, Mental Illness in Old Age’’, E. Kraepelin stated, “The realm of late-life psychiatric disorders is perhaps the most unclear in the entirety of psychiatry.’’ More than a century later, it remains challenging to fully understand late-life psychiatric disorders, including late-life depression, late-life bipolar disorder, and late-life delusional states such as late paraphrenia. However, recent years have seen significant advancements. Neuropathological examinations of these late-life psychiatric disorders are gradually uncovering the underlying diseases

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Grzywacz, Anna, Małgorzata Ryder, Iwona Małecka, and Jolanta Chmielowiec. "The current state of research on psychiatric genetics in Poland and the world: A report covering recent years." Postępy Higieny i Medycyny Doświadczalnej 72 (January 12, 2018): 1–12. http://dx.doi.org/10.5604/01.3001.0010.7979.

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The aim of this article was to review the results of research carried out in recent years in relation to genetic studies in psychiatry. The authors’ focus is on the selected disorders, with particular emphasis on the reports from Poland. For this purpose, the most often mentioned studies describing genes and biomarkers involved in psychiatry were selected. Genetic polymorphisms were described in relation to schizophrenia, alcoholism, addiction to psychoactive substances, autistic spectrum, unipolar depression and bipolar disorder, eating disorders and other psychiatric disorders. Characterizin

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Delvecchio, G., M. Serpente, L. Di Consoli, et al. "Investigating Epigenetic and Neuroimaging Profiles in Bipolar Disorder and Behavioral Variant Frontotemporal Dementia: An integrated epigenetic-neuroimaging approach." European Psychiatry 67, S1 (2024): S625. http://dx.doi.org/10.1192/j.eurpsy.2024.1296.

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IntroductionDiscriminating between bipolar disorder (BD) and behavioral variant Frontotemporal Dementia (bvFTD) is a clinical challenge as it is still based on clinical judgement, which often leads to misdiagnosis. This challenge is particularly pronounced in cases involving the C9orf72 hexanucleotide expansion, a genetic factor responsible for a substantial portion of familial FTD cases, as in these patients the development of late psychoses is particularly frequent. Moreover, individuals with C9orf72 bvFTD are also characterized by behavioral changes that resemble those seen in late-life BD,

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Velakoulis, Dennis, and Dhamidhu Eratne. "Using the axonal protein neurofilament light to distinguish psychiatric and neurodegenerative disorders across a program of clinical research studies." International Psychogeriatrics 35, S1 (2023): 7–8. http://dx.doi.org/10.1017/s1041610223001552.

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Introduction:There is an urgent need for clinical blood biomarkers which can rule in/out neurological disorders early in those with psychiatric symptoms, personality or behavioural changes and/or functional decline together with cognitive symptoms. The neuronal axonal protein neurofilament light (NfL) is released from damaged neuronal axons and can be measured in in blood and cerebrospinal fluid (CSF). We have undertaken a series of studies aimed at examining the clinical utility of blood and CSF NfL in assisting with the distinction between psychiatric and neurodegenerative / neurological dis

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Loi, Samantha M., Dhamidhu Eratne, Alexander F. Santillo, and Dennis Velakoulis. "Biofluid biomarkers in distinguishing young-onset dementia from primary psychiatric disorders." Current Opinion in Psychiatry 38, no. 2 (2025): 134–43. https://doi.org/10.1097/yco.0000000000000979.

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Purpose of review There has been growing interest in the role of biofluid biomarkers to aid the diagnosis of dementia in older people. However, less attention has been given to younger people who have dementia (young-onset dementia), who frequently experience misdiagnoses of primary psychiatric disorders diagnostic delay and challenges accessing appropriate care. Recent findings We describe 12 studies from the previous 2 years of which the majority have investigated the role of neurofilament light chain protein (NfL) in blood and cerebrospinal fluid in distinguishing young-onset dementia from

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Haq, Wadood, Eberhart Zrenner, Marius Ueffing, and François Paquet-Durand. "Using Micro-Electrode-Array Recordings and Retinal Disease Models to Elucidate Visual Functions: Simultaneous Recording of Local Electroretinograms and Ganglion Cell Action Potentials Reveals the Origin of Retinal Oscillatory Potentials." Bioengineering 10, no. 6 (2023): 725. http://dx.doi.org/10.3390/bioengineering10060725.

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Background: The electroretinogram (ERG) is an essential diagnostic tool for visual function, both in clinical and research settings. Here, we establish an advanced in vitro approach to assess cell-type-specific ERG signal components. Methods: Retinal explant cultures, maintained under entirely controlled conditions, were derived from wild-type mice and rd10 rod- and cpfl1 cone-degeneration mouse models. Local micro-ERG (µERG) and simultaneous ganglion cell (GC) recordings were obtained from the retinal explants using multi-electrode arrays. Band-pass filtering was employed to distinguish photo

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Wyględowska-Promieńska, Dorota, Marta Świerczyńska, Dorota Śpiewak, et al. "Aland Island Eye Disease with Retinoschisis in the Clinical Spectrum of CACNA1F-Associated Retinopathy—A Case Report." International Journal of Molecular Sciences 25, no. 5 (2024): 2928. http://dx.doi.org/10.3390/ijms25052928.

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Aland island eye disease (AIED), an incomplete form of X-linked congenital stationary night blindness (CSNB2A), and X-linked cone-rod dystrophy type 3 (CORDX3) display many overlapping clinical findings. They result from mutations in the CACNA1F gene encoding the α1F subunit of the Cav1.4 channel, which plays a key role in neurotransmission from rod and cone photoreceptors to bipolar cells. Case report: A 57-year-old Caucasian man who had suffered since his early childhood from nystagmus, nyctalopia, low visual acuity and high myopia in both eyes (OU) presented to expand the diagnostic process

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Wu, Xuan, Yaqi Song, and Xinrui Zhao. "Exploring Memes as a Form of Illness Trivialization in Young People: Social and Psychological ConsequencesA Literature Review." Communications in Humanities Research 64, no. 1 (2024): 50–55. https://doi.org/10.54254/2753-7064/2024.18988.

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In recent years, network culture and humor, particularly among young people, have exhibited distinct age-related characteristics. A notable and concerning trend within this culture is the increasing trivialization phenomenon of serious illnesses. Conditions such as depression, suicide, bipolar disorder, and Down Syndrome are increasingly being trivialized and used as subjects of jokes and self-mockery in online discourse and everyday conversation. While diseases are humorized and made light of, many patients and their families, who are deeply affected by these illnesses, continue to struggle n

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Wiratnaya, I. Gede Eka, Sri Mahadhana, Andrew Sutheno, Leonardus William Kuswara, and Nyoman Gede Grenata Nanda Ustriyana. "Lactate dehydrogenase (LDH) and C-reactive protein (CRP) as a potential prognostic factor in metastatic bone disease (MBD) of proximal femur based on Harris hip score (HHS) underwent cephalomedullary nailing and bipolar hemiarthroplasty." Bali Medical Journal 12, no. 2 (2023): 2378–82. http://dx.doi.org/10.15562/bmj.v12i2.4714.

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Introduction: Pathological fractures in the proximal femur are common, often caused by metastatic bone disease (MBD). Treatment options include resection, reconstruction, or fixation. This study explores the prognostic value of C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels in the Harris Hip Score (HHS) for patients with pathological fractures due to MBD. Methods: Forty patients with pathological fractures were divided into cephalomedullary nail (CM) and bipolar hemiarthroplasty (BHA) groups. CRP and LDH levels were measured. The correlation between CRP, LDH, and HHS was asses

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Chen, Bo, Bogale Aredo, Yi Ding, et al. "Forward genetic analysis using OCT screening identifiesSfxn3mutations leading to progressive outer retinal degeneration in mice." Proceedings of the National Academy of Sciences 117, no. 23 (2020): 12931–42. http://dx.doi.org/10.1073/pnas.1921224117.

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Retinal disease and loss of vision can result from any disruption of the complex pathways controlling retinal development and homeostasis. Forward genetics provides an excellent tool to find, in an unbiased manner, genes that are essential to these processes. UsingN-ethyl-N-nitrosourea mutagenesis in mice in combination with a screening protocol using optical coherence tomography (OCT) and automated meiotic mapping, we identified 11 mutations presumably causative of retinal phenotypes in genes previously known to be essential for retinal integrity. In addition, we found multiple statistically

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Evrensel, Alper, and Nevzat Tarhan. "Inflammation Biomarkers in Psychiatry." Current Psychiatry Research and Reviews 16, no. 2 (2020): 78–85. http://dx.doi.org/10.2174/2666082216999200625115701.

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Introduction: There has long been a need for diagnostic, theragnostic, and prognostic biomarkers for psychiatric disorders. Biomarkers help in reducing ambiguity and arbitrariness and increase objectivity. In this context, many candidates for hormonal, immunological, serological, and neuroimaging markers have been proposed, but none of these marker candidates alone nor a biomarker panel has been approved for any disease. The fact that almost all psychiatric disorders are heterogeneous makes this process challenging. However, strong biomarker candidates have been identified, especially in light

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Pangestiningsih, Tri Wahyu, Woro Danur Wendo, Yulfia Nelymalik Selan, Filphin Adolfin Amalo, Nemay Anggadewi Ndaong, and Victor Lenda. "Histological Features of Catecholaminergic Neuron in Substantia Nigra Induced by Paraquat Dichloride (1,1-dimethyl-4,4 bipyridinium) in Wistar Rat as A Model of Parkinson Disease." Indonesian Journal of Biotechnology 19, no. 1 (2015): 91. http://dx.doi.org/10.22146/ijbiotech.8638.

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Paraquat dichloride has been used by farmers as a herbicide to kill the grass. On the other hand, paraquatdichloride is harmful if enters to the body, causing Parkinson’s disease, since it is disrupting dopamineproduction in the substantia nigra pars compacta or dopamine pathways Nigro striatal pathway. The studywas done to fi nd out the histological changes of catecholaminergic neurons and Nigro striatal pathway causedby paraquat dichloride treatment in Wistar rats as a model of Parkinson’s disease.Twenty-two Wistar rats 3,5 months old were divided into 4 groups, 5 rats each. Group I (control

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Santos, Helena Lúcia Carneiro, Gabriela Linhares Pereira, Rhagner Bonono do Reis, Igor Cardoso Rodrigues, Claudia Masini d’Avila, and Vitor Ennes Vidal. "Using Acanthamoeba spp. as a cell model to evaluate Leishmania infections." PLOS Neglected Tropical Diseases 18, no. 10 (2024): e0012517. http://dx.doi.org/10.1371/journal.pntd.0012517.

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Leishmaniasis represents a severe global health problem. In the last decades, there have been significant challenges in controlling this disease due to the unavailability of licensed vaccines, the high toxicity of the available drugs, and an unrestrained surge of drug-resistant parasites, and human immunodeficiency virus (HIV)–Leishmania co-infections. Leishmania spp. preferentially invade macrophage lineage cells of vertebrates for replication after subverting cellular functions of humans and other mammals. These early events in host–parasite interactions are likely to influence the future co

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Pereira, Priscila Moreira de Lima, and Ana paula Carlos Cándido. "Medidas antropométricas para la evaluación de la masa muscular en pacientes con enfermedad renal crónica bajo tratamiento conservador." Nutrición Clínica y Dietética Hospitalaria 40, no. 2 (2020): 120–27. https://doi.org/10.12873/402pereira.

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Introduction: Patients with chronic kidney disease (CKD) have increased protein catabolism, leading to worse quality of life, cardiometabolic complications and increased risk of hospitalizations. Nutritional assessment is important, although it has limitations due to changes in body water and bone mass. The aim of the study was to identify the correlation of anthropometric measurements with muscle mass in patients with CKD. Methods: Epidemiological cross-sectional study. Patients with CKD under conservative treatment from 60 years of age were evaluated. We collected: weight, height, BMI, arm c

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Hong, Eunji, Christopher Glynn, Qianbin Wang, and Siyuan Rao. "Non-Invasive Electroretinogram Recording with Simultaneous Optogenetics to Dissect Retinal Ganglion Cells Electrophysiological Dynamics." Biosensors 13, no. 1 (2022): 42. http://dx.doi.org/10.3390/bios13010042.

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Electroretinography (ERG) is a non-invasive electrophysiological recording technique that detects the electrical signaling of neuronal cells in the visual system. In conventional ERG recordings, the signals are considered a collective electrical response from various neuronal cell populations, including rods, cones, bipolar cells, and retinal ganglion cells (RGCs). However, due to the limited ability to control electrophysiological responses from different types of cells, the detailed information underlying ERG signals has not been analyzed and interpreted. Linking the features of ERG signals

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Magnusson, Andres, and Timo Partonen. "The Diagnosis, Symptomatology, and Epidemiology of Seasonal Affective Disorder." CNS Spectrums 10, no. 8 (2005): 625–34. http://dx.doi.org/10.1017/s1092852900019593.

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AbstractThe operational criteria for seasonal affective disorder (SAD) have undergone several changes since first proposed in 1984. SAD is currently included as a specifier of either bipolar or recurrent major depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The International Classification of Diseases, Tenth Edition has provisional diagnostic criteria for SAD. The most characteristic quality of SAD is that the symptoms usually present during winter and remit in the spring. Furthermore, the symptoms tend to remit when the patients are exposed to

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Connors, Michael H., Lena Quinto, and Henry Brodaty. "Longitudinal outcomes of patients with pseudodementia: a systematic review." Psychological Medicine 49, no. 5 (2018): 727–37. http://dx.doi.org/10.1017/s0033291718002829.

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AbstractDepression and a number of other psychiatric conditions can impair cognition and give the appearance of neurodegenerative disease. Collectively, this group of disorders is known as ‘pseudodementia’ and are important to identify given their potential reversibility with treatment. Despite considerable interest historically, the longitudinal outcomes of patients with pseudodementia remain unclear. We conducted a systematic review of longitudinal studies of pseudodementia. Bibliographic databases were searched using a wide range of search terms. Two reviewers independently assessed papers

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