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Journal articles on the topic 'Light GBM'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Vasilev, Alex, Roba Sofi, Ruman Rahman, Stuart J. Smith, Anja G. Teschemacher, and Sergey Kasparov. "Using Light for Therapy of Glioblastoma Multiforme (GBM)." Brain Sciences 10, no. 2 (2020): 75. http://dx.doi.org/10.3390/brainsci10020075.

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Glioblastoma multiforme (GBM) is the most malignant form of primary brain tumour with extremely poor prognosis. The current standard of care for newly diagnosed GBM includes maximal surgical resection followed by radiotherapy and adjuvant chemotherapy. The introduction of this protocol has improved overall survival, however recurrence is essentially inevitable. The key reason for that is that the surgical treatment fails to eradicate GBM cells completely, and adjacent parenchyma remains infiltrated by scattered GBM cells which become the source of recurrence. This stimulates interest to any su

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Savige, J. A., S. P. Yeung, A. R. Bierre, and Priscilla Kincaid-Smith. "Lambda-Light-Chain-Mediated Anti-GBM Disease." Nephron 52, no. 2 (1989): 144–48. http://dx.doi.org/10.1159/000185617.

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Dumitru, Claudia Alexandra, Eileen Brouwer, Tamina Stelzer, et al. "Dynein Light Chain Protein Tctex1: A Novel Prognostic Marker and Molecular Mediator in Glioblastoma." Cancers 13, no. 11 (2021): 2624. http://dx.doi.org/10.3390/cancers13112624.

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The purpose of this study was to determine the role of Tctex1 (DYNLT1, dynein light chain-1) in the pathophysiology of glioblastoma (GBM). To this end, we performed immunohistochemical analyses on tissues from GBM patients (n = 202). Tctex1 was additionally overexpressed in two different GBM cell lines, which were then evaluated in regard to their proliferative and invasive properties. We found that Tctex1 levels were significantly higher in GBM compared to healthy adjacent brain tissues. Furthermore, high Tctex1 expression was significantly associated with the short overall- (p = 0.002, log-r

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Han, Mingzhi, and Xingang Li. "IMMU-23. CLINICAL AND IMMUNOLOGICAL CHARACTERIZATION OF IMMUNE CHECKPOINT MOLECULE LIGHT IN HUMAN GLIOMAS." Neuro-Oncology 22, Supplement_2 (2020): ii109. http://dx.doi.org/10.1093/neuonc/noaa215.453.

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Abstract BACKGROUND Dysregulation of immune checkpoint molecules leads to immune evasion in human tumors but has become a viable target for tumor therapy. Here, we examined expression of LIGHT (TNFSF14), an immune checkpoint molecule, in human glioblastoma (GBM) to assess its potential as a molecular target for treatment. METHODS Molecular and clinical data from publicly available genomic databases containing WHO grade II-IV human glioma cases were analyzed. Immunohistochemistry was applied to assess LIGHT protein levels in primary tumor sections. Statistical analysis was performed using Matla

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Dr.S. Poornima, K Elankumaran, M Nandhana, B Parthasarathy, and V Sudharshan. "Autonomous Vehicle Lane-Changing System using Light GBM." International Research Journal on Advanced Engineering Hub (IRJAEH) 3, no. 07 (2025): 3185–94. https://doi.org/10.47392/irjaeh.2025.0469.

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Traffic dynamics and autonomous vehicle navigation depend heavily on lane-changing behaviour. This paper introduces a machine learning-based method to predict lane-changing intentions using vehicle trajectory data and driver behaviour analysis. Our model achieves high accuracy while maintaining computational efficiency by utilizing the Gaussian Mixture Model (GMM) for driver behaviour clustering and LightGBM for lane-change classification. The system incorporates feature engineering, and hyperparameter optimization to improve prediction reliability. Our experimental results show that the sugge

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Kruthika, Banavathy S., Harsha Sugur, Kanuri Nandaki, Arivazhagan Arimappamagan, Kondaiah Paturu, and Vani Santosh. "Expression pattern and prognostic significance of myosin light chain 9 (MYL9): a novel biomarker in glioblastoma." Journal of Clinical Pathology 72, no. 10 (2019): 677–81. http://dx.doi.org/10.1136/jclinpath-2019-205834.

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AimsTumour recurrence is inevitable in glioblastoma (GBM) and mostly noted in the peritumoural brain zone (PT). In our previous microarray-based study, we identified Myosin Light Chain 9 (MYL9) as a highly expressed gene in the PT of GBM. Therefore, we aimed to study the expression pattern and clinical significance of MYL9 in GBM.MethodsPatient samples included three retrospective cohorts: 25 GBM cases with differential biopsies of tumour core and PT, 62 retrospective cases of newly diagnosed GBM with survival information and 20 paired samples (newly diagnosed and recurrent GBM). All tumour ti

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Becker, Aline, Blake Sells, S. Haque, and Arnab Chakravarti. "Tumor Heterogeneity in Glioblastomas: From Light Microscopy to Molecular Pathology." Cancers 13, no. 4 (2021): 761. http://dx.doi.org/10.3390/cancers13040761.

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One of the main reasons for the aggressive behavior of glioblastoma (GBM) is its intrinsic intra-tumor heterogeneity, characterized by the presence of clonal and subclonal differentiated tumor cell populations, glioma stem cells, and components of the tumor microenvironment, which affect multiple hallmark cellular functions in cancer. “Tumor Heterogeneity” usually encompasses both inter-tumor heterogeneity (population-level differences); and intra-tumor heterogeneity (differences within individual tumors). Tumor heterogeneity may be assessed in a single time point (spatial heterogeneity) or al

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Vasilev, Alex, Roba Sofi, Stuart J. Smith, Ruman Rahman, Anja G. Teschemacher, and Sergey Kasparov. "Feasibility of Photodynamic Therapy for Glioblastoma with the Mitochondria-Targeted Photosensitizer Tetramethylrhodamine Methyl Ester (TMRM)." Biomedicines 9, no. 10 (2021): 1453. http://dx.doi.org/10.3390/biomedicines9101453.

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One of the most challenging problems in the treatment of glioblastoma (GBM) is the highly infiltrative nature of the disease. Infiltrating cells that are non-resectable are left behind after debulking surgeries and become a source of regrowth and recurrence. To prevent tumor recurrence and increase patient survival, it is necessary to cleanse the adjacent tissue from GBM infiltrates. This requires an innovative local approach. One such approach is that of photodynamic therapy (PDT) which uses specific light-sensitizing agents called photosensitizers. Here, we show that tetramethylrhodamine met

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Bielecka-Wajdman, Anna M., Tomasz Ludyga, Grzegorz Machnik, Miłosz Gołyszny, and Ewa Obuchowicz. "Tricyclic Antidepressants Modulate Stressed Mitochondria in Glioblastoma Multiforme Cells." Cancer Control 25, no. 1 (2018): 107327481879859. http://dx.doi.org/10.1177/1073274818798594.

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A common feature of solid tumors, including glioblastoma multiforme (GBM), is mitochondrial dysfunction. However, it is reported that the current standard of anti-GBM therapies may potentiate mitochondrial damage and, in effect, support the aggressive character of cancer. As mitochondria are implicated in the modulation of cellular drug sensitivity and chemoresistance mechanisms, activation-stressed mitochondria in GBM cells may represent a new target for anti-GBM therapy that is nontoxic for normal cells. Methods: As mitochondria are possible targets for antidepressant drugs used as adjuvant

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Dupont, Clement, Fabienne Lecomte, Marie-Edith Bonneterre, Maximilien Vermandel, and Constantinos Hadjipanayis. "SURG-18. INNOVATIVE DRUG-DEVICE COMBINATION FOR THE PHOTODYNAMIC TREATMENT OF PRIMARY GLIOBLASTOMA (GBM) PATIENTS." Neuro-Oncology 26, Supplement_8 (2024): viii277. http://dx.doi.org/10.1093/neuonc/noae165.1098.

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Abstract Despite advances in neurosurgical technology and techniques, the survival rate of GBM patients has remained relatively unchanged. The main treatments for GBM are associated with difficulties resulting from incomplete tumor resection and recurrence. In such situations, Photodynamic Therapy (PDT) is increasingly popular as an advanced therapeutic strategy, characterized by fewer side effects, minimal toxicity, and more controlled treatment. 5-aminolevulinic acid hydrochloride, (5-ALA HCl) has been used for years as a photosensitizing drug for the intraoperative visualization of GBM tumo

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Wu, Qiong, Anders Berglund, Dapeng Wang, et al. "GENE-46. XAF1 DRIVES DIFFERENTIAL PLASTICITY TOWARDS ADAPTIVE RESISTANCE BETWEEN MGMT-HYPERMETHYLATED AND MGMT-HYPOMETHYLATED GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (2019): vi107. http://dx.doi.org/10.1093/neuonc/noz175.448.

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Abstract Although, the epigenetic regulation of O6-alkylguanine DNA alkyltransferase (MGMT) in GBM is an established surrogate of intrinsic resistance to temozolomide (TMZ), the evolution of GBM habitats towards adaptive resistance to TMZ relative to MGMT promoter methylation status remains unclear. We report a novel epigenetic regulation of plasticity towards adaptive resistance in GBM. Using an adaptive TMZ resistance model of MGMT-hypermethylated and MGMT-hypomethylated GBM cellular habitats, a counter-intuitive inverse correlation was noted between intrinsic MGMT-dependent TMZ resistance v

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Schweiger, Markus, Mao Li, Renata Fleming, Elie Tabet, Thomas Würdinger, and Bakhos Tannous. "STEM-15. SMALL BUT FIERCE: THE ROLE OF EXTRACELLULAR VESICLES IN MESENCHYMAL TRANSITION AND THERAPEUTIC RESISTANCE IN GLIOBLASTOMA." Neuro-Oncology 22, Supplement_2 (2020): ii199. http://dx.doi.org/10.1093/neuonc/noaa215.832.

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Abstract Glioblastoma (GBM) is a dismal disease and despite optimal treatment, long-term survival remains uncommon. Molecular classification revealed three distinct GBM subgroups and has helped to shine light on the tumor’s inter/intratumoral heterogeneity. Interestingly, recent evidence shows plasticity between these subtypes in which the proneural (PN) glioma stem-like cells undergo transition into the more aggressive mesenchymal (MES) subtype leading to therapeutic resistance. Extracellular vesicles (EVs) are considered a heterogeneous group of membrane-limited vesicles secreted by nearly e

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Sudhir, Sweta, Maria Anastasiadou, Gabrielle Price, and Constantinos Hadjipanayis. "CSIG-18. ANTI-TUMOR EFFECTS OF VERTEPORFIN AND PHOTODYNAMIC THERAPY IN COMBINATION WITH STANDARD OF CARE ON PATIENT-DERIVED GBM CELL LINES." Neuro-Oncology 24, Supplement_7 (2022): vii42—vii43. http://dx.doi.org/10.1093/neuonc/noac209.167.

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Abstract Glioblastoma (GBM) is the most common and aggressive primary brain tumor with a median survival of approximately 15 months. GBM tumorigenicity frequently arises from aberrant signaling transduction pathways involving receptor tyrosine kinases (RTKs), such as EGFR and PI3K. Amplification of the Epidermal Growth Factor Receptor (EGFR) gene upregulates Hippo pathway transcription factors YAP1 and TAZ, leading to tumor cell proliferation, radiation resistance, and poor survival. Verteporfin (VP), also known as Visudyne, is an FDA-approved macular degeneration photosensitizer that has phot

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Tajiknia, Vida, Wafik El Deiry, Lanlan Zhou, William Macdonald, and Praveen Srinivasan. "Abstract A050: Ferritin, associated with worse overall survival in recurrent GBM, is reduced by combination of HDACi, ONC206 and radiation." Cancer Research 84, no. 5_Supplement_1 (2024): A050. http://dx.doi.org/10.1158/1538-7445.brain23-a050.

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Abstract Background: GBM is the most common primary brain malignancy with dismal prognosis. Current standard of care is chemoradiation&surgery. The main issue with GBM is the resistance & recurrence. GBM can have high Ferritin levels associated with disease progression & immunosuppression in the GBM TME. Ferritin light chain (FTL), a key protein in iron metabolism, is mutated in GBM leading to high ferritin levels (both light& heavy chain) & is associated with poor survival of (GBM) patients in part due to inhibition of ferroptosis. Panobinostat is a histone deacetylase inh

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Spatz, Jordan Matthew, Ming Ru Wu, Karen Weisinger, Tim Lu, and Manish Aghi. "3352 Surgical Adjuvant of Immunomodulatory Gene Circuits for Treatment of Glioblastoma." Journal of Clinical and Translational Science 3, s1 (2019): 155. http://dx.doi.org/10.1017/cts.2019.355.

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OBJECTIVES/SPECIFIC AIMS: Glioblastoma (GBM) is a brain cancer with a devastatingly short overall survival of under two years. The poor prognosis of GBM is largely due to cell invasion and maintenance of cancer initiating cells that evade the brain’s innate and adaptive immune responses which enables escape from surgical resection and drives inevitable recurrence. While targeting the brain’s immune microenvironment has long been proposed as a strategy for treating GBM, translational progress has been slow, underscoring the need to investigate the brain’s immune microenvironment for therapeutic

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Yin, Yi-Han Iris, Bin-Bin Zhang, Jun Yang, et al. "Triggering the Untriggered: The First Einstein Probe-detected Gamma-Ray Burst 240219A and Its Implications." Astrophysical Journal Letters 975, no. 2 (2024): L27. http://dx.doi.org/10.3847/2041-8213/ad8652.

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Abstract The Einstein Probe (EP) achieved its first detection and localization of a bright X-ray flare, EP240219a, on 2024 February 19, during its commissioning phase. Subsequent targeted searches triggered by the EP240219a alert identified a faint, untriggered gamma-ray burst (GRB) in the archived data of Fermi Gamma-ray Burst Monitor (GBM), Swift Burst Alert Telescope (BAT), and Insight-HXMT/HE. The EP Wide-field X-ray Telescope (WXT) light curve reveals a long duration of approximately 160 s with a slow decay, whereas the Fermi/GBM light curve shows a total duration of approximately 70 s. T

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Bhanja, Debarati, Hannah Wilding, Angel Baroz, et al. "Photodynamic Therapy for Glioblastoma: Illuminating the Path toward Clinical Applicability." Cancers 15, no. 13 (2023): 3427. http://dx.doi.org/10.3390/cancers15133427.

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Glioblastoma (GBM) is the most common adult brain cancer. Despite extensive treatment protocols comprised of maximal surgical resection and adjuvant chemo–radiation, all glioblastomas recur and are eventually fatal. Emerging as a novel investigation for GBM treatment, photodynamic therapy (PDT) is a light-based modality that offers spatially and temporally specific delivery of anti-cancer therapy with limited systemic toxicity, making it an attractive option to target GBM cells remaining beyond the margins of surgical resection. Prior PDT approaches in GBM have been predominantly based on 5-am

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La Torre, Domenico, Attilio Della Torre, Erica Lo Turco, et al. "Primary Intracranial Gliosarcoma: Is It Really a Variant of Glioblastoma? An Update of the Clinical, Radiological, and Biomolecular Characteristics." Journal of Clinical Medicine 13, no. 1 (2023): 83. http://dx.doi.org/10.3390/jcm13010083.

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Gliosarcomas (GS) are sporadic malignant tumors classified as a Glioblastoma (GBM) variant with IDH-wild type phenotype. It appears as a well-circumscribed lesion with a biphasic, glial, and metaplastic mesenchymal component. The current knowledge about GS comes from the limited literature. Furthermore, recent studies describe peculiar characteristics of GS, such as hypothesizing that it could be a clinical–pathological entity different from GBM. Here, we review radiological, biomolecular, and clinical data to describe the peculiar characteristics of PGS, treatment options, and outcomes in lig

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Barzegar Behrooz, Amir, Zahra Talaie, and Amir Syahir. "Nanotechnology-Based Combinatorial Anti-Glioblastoma Therapies: Moving from Terminal to Treatable." Pharmaceutics 14, no. 8 (2022): 1697. http://dx.doi.org/10.3390/pharmaceutics14081697.

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Aggressive glioblastoma (GBM) has no known treatment as a primary brain tumor. Since the cancer is so heterogeneous, an immunosuppressive tumor microenvironment (TME) exists, and the blood–brain barrier (BBB) prevents chemotherapeutic chemicals from reaching the central nervous system (CNS), therapeutic success for GBM has been restricted. Drug delivery based on nanocarriers and nanotechnology has the potential to be a handy tool in the continuing effort to combat the challenges of treating GBM. There are various new therapies being tested to extend survival time. Maximizing therapeutic effect

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Chae, Minsu, Heesoo Yoon, Hwamin Lee, and June Choi. "Hearing Recovery Prediction for Patients with Chronic Otitis Media Who Underwent Canal-Wall-Down Mastoidectomy." Journal of Clinical Medicine 13, no. 6 (2024): 1557. http://dx.doi.org/10.3390/jcm13061557.

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Background: Chronic otitis media affects approximately 2% of the global population, causing significant hearing loss and diminishing the quality of life. However, there is a lack of studies focusing on outcome prediction for otitis media patients undergoing canal-wall-down mastoidectomy. Methods: This study proposes a recovery prediction model for chronic otitis media patients undergoing canal-wall-down mastoidectomy, utilizing data from 298 patients treated at Korea University Ansan Hospital between March 2007 and August 2020. Various machine learning techniques, including logistic regression

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Ho, Nguyen Thi Thanh, Chinmay Satish Rahane, Subrata Pramanik, Pok-Son Kim, Arne Kutzner, and Klaus Heese. "FAM72, Glioblastoma Multiforme (GBM) and Beyond." Cancers 13, no. 5 (2021): 1025. http://dx.doi.org/10.3390/cancers13051025.

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Neural stem cells (NSCs) offer great potential for regenerative medicine due to their excellent ability to differentiate into various specialized cell types of the brain. In the central nervous system (CNS), NSC renewal and differentiation are under strict control by the regulation of the pivotal SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2)—Family with sequence similarity 72 (FAM72) master gene (i.e., |-SRGAP2–FAM72-|) via a divergent gene transcription activation mechanism. If the gene transcription control unit (i.e., the intergenic region of the two sub-gene units, SRGAP2 and FAM72) g

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Drumm, Michael, Karan Dixit, Sean Grimm, et al. "HOUT-11. EXTENSIVE BRAINSTEM INFILTRATION, NOT MASS EFFECT, IS A COMMON FEATURE OF END-STAGE CEREBRAL GLIOBLASTOMAS." Neuro-Oncology 21, Supplement_6 (2019): vi114. http://dx.doi.org/10.1093/neuonc/noz175.476.

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Abstract BACKGROUND Progress in extending the survival of glioblastoma (GBM) patients has been slow, suggesting that preclinical and clinical trial approaches may not fully take into account the nature of this cancer. A better understanding of why GBM patient survival remains poor is critical to developing new strategies. Postmortem studies on GBM can shed light on how GBM spreads and how GBM patients are dying. METHODS The brains of 25 GBM patients were autopsied and examined for gross and microscopic abnormalities. Clinical-pathologic correlations were accomplished through detailed chart rev

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Goud, Dadi Jagan. "Cryptocurrency Prediction." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 06 (2025): 1–9. https://doi.org/10.55041/ijsrem51114.

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Cryptocurrency price prediction has become crucial for informed trading decisions due to the volatile nature of assets like Bitcoin, Ethereum, Ripple, and Litecoin. Traditional methods like ARIMA and GARCH struggle with this volatility, while modern approaches such as machine learning and deep learning provide better accuracy. This study evaluates advanced models, including LSTM, GRU, and Light GBM, to predict cryptocurrency prices and assess trading strategies before and after the COVID-19 pandemic. GRU and LSTM excel at identifying patterns in price data, with GRU performing best for Ripple.

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Wang, Lin, Karin Shamardani, Husam Babikir, et al. "EPCO-10. CHANGES IN ALTERNATIVE SPLICING AND ASSOCIATED NEOANTIGENS DUE TO THERAPY." Neuro-Oncology 22, Supplement_2 (2020): ii71. http://dx.doi.org/10.1093/neuonc/noaa215.289.

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Abstract Recent studies have identified alternative splicing (AS) as a novel source of neoantigens for immunotherapy. Surprisingly little is known about the AS milieu in recurrent glioblastoma (GBM), despite this being the venue for most clinical trials. We profiled 29 primary-recurrent paired human GBM specimens via RNA sequencing and re-analyzed RNA-sequencing data from non-malignant human brain tissues. From these data, we reconstructed the landscape of AS in GBM through recurrence and contrasted that to isoforms observed in non-malignant brain. The AS events we identified were cross-refere

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Meneses, João, Tom van de Kemp, Raquel Costa-Almeida, et al. "Fabrication of Polymer/Graphene Biocomposites for Tissue Engineering." Polymers 14, no. 5 (2022): 1038. http://dx.doi.org/10.3390/polym14051038.

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Graphene-based materials (GBM) are considered one of the 21st century’s most promising materials, as they are incredibly light, strong, thin and have remarkable electrical and thermal properties. As a result, over the past decade, their combination with a diverse range of synthetic polymers has been explored in tissue engineering (TE) and regenerative medicine (RM). In addition, a wide range of methods for fabricating polymer/GBM scaffolds have been reported. This review provides an overview of the most recent advances in polymer/GBM composite development and fabrication, focusing on methods s

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Thapa, Bikram Bahadur, Joshan Neupane, and Sunil Moktan. "Bilateral Blindness Due to Left Fronto-Temporal Lobe Glioblastoma Multiforme." Journal of Nepalgunj Medical College 18, no. 1 (2020): 107–10. http://dx.doi.org/10.3126/jngmc.v18i1.35224.

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Introduction: Glioblastoma multiforme is the most common primary malignant brain tumor, with a very poor prognosis. Direct compression of any structure in the visual pathway or chronic papilloedema is the cause of loss of vision in these patients. Case Report: 30 years old male from Dailekh was brought by his elder brother with the complaint of complete vision loss in both eyes for 45 days. He also had hearing difficulty on right side, headache, right sided weakness and abnormal body movement. His Visual acuity was no perception of Light in both eyes. Pupil was mid-dilated and not reacti

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Wardhana, Indrawata, Musi Ariawijaya, Vandri Ahmad Isnaini, and Rahmi Putri Wirman. "Gradient Boosting Machine, Random Forest dan Light GBM untuk Klasifikasi Kacang Kering." Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) 6, no. 1 (2022): 92–99. http://dx.doi.org/10.29207/resti.v6i1.3682.

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Bean seed classification is critical in determining the quality of beans. Previously, the same dataset was tested using the MLP, SVM, KNN, and DT algorithms, with SVM producing the best results. The purpose of this study is to determine the most effective model through the use of the BoxCox transformation selection feature and the random forest (RF) algorithm, as well as the gradient boosting machine (GBM), light GBM, and repeated k-folds evaluation model. The bean dataset is available on the UCI Repository website. The BoxCox transformation and repeated k-folds improved the classification pre

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Liu, Hao, Yanjia Hu, and Zhaoying Zhu. "ANGI-04. IKIP SUPPRESSES MIGRATION AND INVASION OF GLIOBLASTOMA BY DOWNREGULATING THBS1/FAK SIGNALING." Neuro-Oncology 25, Supplement_5 (2023): v1—v2. http://dx.doi.org/10.1093/neuonc/noad179.0004.

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Abstract BACKGROUND The role of the inhibitor of NF-κB kinase-interacting protein (IKIP) in glioblastoma (GBM) migration and invasion remains poorly understood, despite its known involvement in the negative regulation of NF-κB signaling and inflammation. This study aimed to investigate the impact of IKIP on GBM metastasis and elucidate the underlying molecular mechanisms. METHODS Expression levels of IKIP were analyzed in gliomas and normal brain tissues using bioinformatic analysis of public databases and immunohistochemical staining of clinical samples. Transwell and wound healing assays wer

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Kurniadi, Felix Indra, and Pramitha Dwi Larasati. "Light Gradient Boosting Machine untuk Deteksi Penyakit Stroke." Jurnal SISKOM-KB (Sistem Komputer dan Kecerdasan Buatan) 6, no. 1 (2022): 67–72. http://dx.doi.org/10.47970/siskom-kb.v6i1.328.

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Abstract—Stroke merupakan salah satu penyakit yang berbahaya di dunia penyakit stroke merupakan penyakit kedua yang mengakibatkan kematian. Pada saat ini proses pendeteksian factor resiko seseorang untuk terkena stroke sangat penting dilakukan sebagai early detection. Pada saat ini sudah banyak algoritma machine learning yang mencoba mengatasi permasalahan dalam clinical data seperti SVM, dan Random Forest. Kedua metode ini sayangnya memiliki problem utama terbesar yaitu mudah sekali overfitting dan sangat rentan terhadap noise. Disebabkan oleh kelemahan yang diusulkan oleh kedua metode ini, p

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Horta, Erika, Tobias Walbert, and James Snyder. "EPID-11. OCCURRENCE OF SYSTEMIC CANCER IN PATIENTS WITH GLIOBLASTOMA: POPULATION CHARACTERIZATION AND COMPLICATIONS." Neuro-Oncology 21, Supplement_6 (2019): vi76. http://dx.doi.org/10.1093/neuonc/noz175.311.

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Abstract It is unclear how the diagnosis of a second cancer influences the treatment and complications of patients with glioblastoma (GBM). A chart review of adults with primary or secondary GBM and another systemic cancer seen in the last five years was performed. Demographic data, thromboembolic events, cytopenia and deviations from the standardized GBM treatment protocol (EBRT with 60 Gy plus concurrent temozolomide followed by adjuvant temozolomide) were analyzed. Exclusion criteria was the diagnosis of genetic syndromes that predispose to tumorigenesis. A total of 56 GBM patients with 61

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Sun, Xueqin Sherine, and Alea Mills. "EPCO-27. CHROMATIN REMODELING REPROGRAMS THE TRANSCRIPTION NETWORK IN GLIOBLASTOMA." Neuro-Oncology 26, Supplement_8 (2024): viii7. http://dx.doi.org/10.1093/neuonc/noae165.0026.

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Abstract Fundamentally, cancer arises from genetic and epigenetic alterations that interplay to reprogram gene expression networks, leading to unrestrained proliferation. Glioblastoma (GBM) is the most prevalent and aggressive primary brain cancer, with a median survival of approximately one year and a 5-year survival rate of just 5%. The standard care for GBM patients has remained unchanged for decades, underscoring the need for a better understanding of GBM biology to develop more effective therapies. The relatively low genetic mutation burden in GBM highlights the significant role of epigen

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Sohrabi, Alireza, Elnaz Guivatchian, Weikun Xiao, et al. "TAMI-16. BIOMATERIAL MATRICES TO STUDY GLIOBLASTOMA INVASION." Neuro-Oncology 22, Supplement_2 (2020): ii216. http://dx.doi.org/10.1093/neuonc/noaa215.905.

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Abstract INTRODUCTION Glioblastoma (GBM) is a highly infiltrative and lethal brain cancer. Previous studies have suggested that GBM tumors are stiffer than healthy brain tissues. We posit that local changes in the mechanical microenvironment near the tumor/tissue interface promote migration of GBM cells away from primary tumors. These studies seek to improve our understanding of how mechanical changes to the microenvironment of GBM tumors and surrounding brain tissue drive GBM progression using an in vitro, 3D model incorporating patient-derived primary GBM cells and a brain matrix-mimetic sca

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Choy, Tiffany, Qi Ye, Benjamin Deneen, Melissa Bondy, and Hyun Kyoung Lee. "MODL-38. DEFINING THE ROLE OF DAAM2 R414W MUTATION IN GLIOMAGENESIS AND GBM GROWTH." Neuro-Oncology 25, Supplement_5 (2023): v307. http://dx.doi.org/10.1093/neuonc/noad179.1189.

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Abstract Each year in the United States, more than 13,000 people are diagnosed with glioblastoma multiforme (GBM), and more than 10,000 are estimated to succumb to the disease, making GBM the most common and lethal primary adult brain tumor. Despite advancing therapies, GBM patient survival has not improved over the decades, so it is critical to better understand glioma etiology. The majority of GBM cases arise from a sporadic accumulation of somatic mutations, but approximately 5-10% of gliomas are classified as “familial”, occurring clustered with hereditary cancer predispositions. These fam

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Gaytan, A. S., A. L. Krivoshapkin, A. M. Karaskov, V. V. Kanygin, and A. V. Valentik. "Results of surgical treatment of patients with glioblastomas using a combined 5-ala fluorescent-guided resection." Patologiya krovoobrashcheniya i kardiokhirurgiya 18, no. 3 (2015): 37. http://dx.doi.org/10.21688/1681-3472-2014-2-37-41.

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Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. It was previously shown that 5-ala fluorescence-guided resection (FGR) of malignant gliomas, as compared to white-light microscopy resection, demonstrates a significantly higher frequency of complete removal of the contrast-enhancing tumor and significantly prolongs overall survival. A combination of 5-ala microscopy and endoscopy may provide some benefits for GBM surgery. The purpose of this study was to evaluate the immediate results of combined 5-ala FGR in patients with GBMs. All in all, 80 patients with GBMs we

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Nguyen, Lina, Gabrielle Romena, Ethan Nguyen, et al. "Light-Activated Local Drug Delivery From Hydrogels: Potential for GBM Treatment." OBM Neurobiology 05, no. 01 (2021): 1. http://dx.doi.org/10.21926/obm.neurobiol.2101090.

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Kim, Ji-Yoon, Hun-Seok Lee, and Jin-Seok Oh. "Study on prediction of ship’s power using light GBM and XGBoost." Journal of Advanced Marine Engineering and Technology 44, no. 2 (2020): 174–80. http://dx.doi.org/10.5916/jamet.2020.44.2.174.

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Mashi, Boryanka T., Ibrahim S. Ahmad, Habeebah A. Kakudi, and Jesse J. Tanimu. "An Improved Light GBM using Bayesian Optimization for Vulnerability Exploitation Prediction." Journal of Science Research and Reviews 1, no. 1 (2024): 49–62. https://doi.org/10.70882/josrar.2024.v1i1.17.

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Despite the significant advances in software security research, exploitability prediction remains elusive due to the uncertainty of which vulnerability to be prioritized. Though many studies have been done on vulnerability prediction, some problems still persist such as efficient parameter optimization, which has significant effect on the algorithm performance and efficiency. To address these challenges, we proposed an Improved Light Gradient Boosting Machine (LGBM) model using Bayesian Optimization (BO) Method. Three experiments were conducted to compare prediction accuracy and computational

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Kriz, Wilhelm, Jana Löwen, Giuseppina Federico, Jacob van den Born, Elisabeth Gröne, and Hermann Josef Gröne. "Accumulation of worn-out GBM material substantially contributes to mesangial matrix expansion in diabetic nephropathy." American Journal of Physiology-Renal Physiology 312, no. 6 (2017): F1101—F1111. http://dx.doi.org/10.1152/ajprenal.00020.2017.

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Thickening of the glomerular basement membrane (GBM) and expansion of the mesangial matrix are hallmarks of diabetic nephropathy (DN), generally considered to emerge from different sites of overproduction: GBM components from podocytes and mesangial matrix from mesangial cells. Reevaluation of 918 biopsies with DN revealed strong evidence that these mechanisms are connected to each other, wherein excess GBM components fail to undergo degradation and are deposited in the mesangium. These data do not exclude that mesangial cells also synthesize components that contribute to the accumulation of m

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Cai, Changcheng, Xingyu Chen, Jimin He, et al. "Correlation between LSM1 Expression and Clinical Outcomes in Glioblastoma and Functional Mechanisms." International Journal of Genomics 2023 (November 2, 2023): 1–11. http://dx.doi.org/10.1155/2023/1543620.

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Background. Glioblastoma (GBM) is an aggressive form of brain tumor characterized by limited treatment options and a bleak prognosis. Although the role of Like-Sm 1 (LSM1), a component of the mRNA splicing machinery, has been studied in various cancers, its significance in GBM remains unclear. The purpose of this research was to investigate the expression of LSM1 and its role in driving GBM progression. Methods. We analyzed gene expression data obtained from TCGA and GTEx databases to compare the levels of LSM1 expression between GBM and normal brain tissues. To assess the impact of LSM1, we c

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Chang, Shoujin, Yong He, Haitao Hu, Jiaxin Chai, Minghe Hu, and Chi Zhang. "Development of fault diagnosis platform for liquid rocket engine based on experimental data." Journal of Physics: Conference Series 2093, no. 1 (2021): 012022. http://dx.doi.org/10.1088/1742-6596/2093/1/012022.

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Abstract Aiming at the defects of difficult to establish fault diagnosis models caused by the small scale of liquid rocket engine test data, imbalanced categories and high fault coupling, the fault diagnosis platform with 10 fault diagnosis models are developed for fault diagnosis, covering K-nearest neighbor (KNN) model, optimized KNN model, logistic regression (LR) model, optimized LR model, support vector machine model, K-means model, decision tree model, neural network model, random forest model and light-GBM model. The prediction accuracies of these models are validated based on the exper

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Abikenari, Matthew, Ethan Schonfeld, John Choi, Lily H. Kim, and Michael Lim. "Revisiting glioblastoma classification through an immunological lens: A narrative review." Glioma 7, no. 2 (2024): 3–9. http://dx.doi.org/10.4103/glioma.glioma_4_24.

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Glioblastoma (GBM) is characterized by a high recurrence rate, significant heterogeneity, and poor prognosis. While there has been a shift in recent years to focus on molecular phenotyping, there are limited data regarding the relationship between the immune milieu and heterogeneous molecular signatures in GBM. Given the success of immunotherapies in other cancers such as non-small-cell lung cancer and melanoma, there has been a concerted effort to correlate the immune compartment of the GBM tumor microenvironment to clinical outcomes. The aim of this narrative review is to establish the role

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Gunturkun, Fatma, Berna Bakir-Batu, Adeel Siddiqui, et al. "Development of a Deep Learning Model for Retinal Hemorrhage Detection on Head Computed Tomography in Young Children." JAMA Network Open 6, no. 6 (2023): e2319420. http://dx.doi.org/10.1001/jamanetworkopen.2023.19420.

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ImportanceAbusive head trauma (AHT) in children is often missed in medical encounters, and retinal hemorrhage (RH) is considered strong evidence for AHT. Although head computed tomography (CT) is obtained routinely, all but exceptionally large RHs are undetectable on CT images in children.ObjectiveTo examine whether deep learning–based image analysis can detect RH on pediatric head CT.Design, Setting, and ParticipantsThis diagnostic study included 301 patients diagnosed with AHT who underwent head CT and dilated fundoscopic examinations at a quaternary care children’s hospital. The study asses

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Alhaddad, Lina, Andreyan N. Osipov, and Sergey Leonov. "The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance." International Journal of Molecular Sciences 23, no. 21 (2022): 13577. http://dx.doi.org/10.3390/ijms232113577.

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Ionizing radiation (IR) has been shown to play a crucial role in the treatment of glioblastoma (GBM; grade IV) and non-small-cell lung cancer (NSCLC). Nevertheless, recent studies have indicated that radiotherapy can offer only palliation owing to the radioresistance of GBM and NSCLC. Therefore, delineating the major radioresistance mechanisms may provide novel therapeutic approaches to sensitize these diseases to IR and improve patient outcomes. This review provides insights into the molecular and cellular mechanisms underlying GBM and NSCLC radioresistance, where it sheds light on the role p

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Lin, Martin Hsiu-Chu, Li-Ching Chang, Chiu-Yen Chung, et al. "Photochemical Internalization of Etoposide Using Dendrimer Nanospheres Loaded with Etoposide and Protoporphyrin IX on a Glioblastoma Cell Line." Pharmaceutics 13, no. 11 (2021): 1877. http://dx.doi.org/10.3390/pharmaceutics13111877.

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Glioblastoma multiforme (GBM) is the most common malignant primary neoplasm of the adult central nervous system originating from glial cells. The prognosis of those affected by GBM has remained poor despite advances in surgery, chemotherapy, and radiotherapy. Photochemical internalization (PCI) is a release mechanism of endocytosed therapeutics into the cytoplasm, which relies on the membrane disruptive effect of light-activated photosensitizers. In this study, phototherapy by PCI was performed on a human GBM cell-line using the topoisomerase II inhibitor etoposide (Etop) and the photosensitiz

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Pudelko, Linda, Steven Edwards, Mirela Balan, et al. "An orthotopic glioblastoma animal model suitable for high-throughput screenings." Neuro-Oncology 20, no. 11 (2018): 1475–84. http://dx.doi.org/10.1093/neuonc/noy071.

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Abstract Background Glioblastoma (GBM) is an aggressive form of brain cancer with poor prognosis. Although murine animal models have given valuable insights into the GBM disease biology, they cannot be used in high-throughput screens to identify and profile novel therapies. The only vertebrate model suitable for large-scale screens, the zebrafish, has proven to faithfully recapitulate biology and pathology of human malignancies, and clinically relevant orthotopic zebrafish models have been developed. However, currently available GBM orthotopic zebrafish models do not support high-throughput dr

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Zhou, Chengmao, Ying Wang, Mu-Huo Ji, Jianhua Tong, Jian-Jun Yang, and Hongping Xia. "Predicting Peritoneal Metastasis of Gastric Cancer Patients Based on Machine Learning." Cancer Control 27, no. 1 (2020): 107327482096890. http://dx.doi.org/10.1177/1073274820968900.

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Objective: The aim is to explore the prediction effect of 5 machine learning algorithms on peritoneal metastasis of gastric cancer. Methods: 1080 patients with postoperative gastric cancer were divided into a training group and test group according to the ratio of 7:3. The model of peritoneal metastasis was established by using 5 machine learning (gbm(Light Gradient Boosting Machine), GradientBoosting, forest, Logistic and DecisionTree). Python pair was used to analyze the machine learning algorithm. Gbm algorithm is used to show the weight proportion of each variable to the result. Result: Co

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Ellis, John, Nick E. Mavromatos, and Dimitri V. Nanopoulos. "Remarks on graviton propagation in light of GW150914." Modern Physics Letters A 31, no. 26 (2016): 1675001. http://dx.doi.org/10.1142/s0217732316750018.

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The observation of gravitational waves from the Laser Interferometer Gravitational-Wave Observatory (LIGO) event GW150914 may be used to constrain the possibility of Lorentz violation in graviton propagation, and the observation by the Fermi Gamma-Ray Burst Monitor (GBM) of a transient source in apparent coincidence may be used to constrain the difference between the velocities of light and gravitational waves: [Formula: see text].

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Menezes, Aline, Gustavo Henrique dos Reis, Maria Cecília Oliveira-Nunes, et al. "Live Cell Imaging Supports a Key Role for Histone Deacetylase as a Molecular Target during Glioblastoma Malignancy Downgrade through Tumor Competence Modulation." Journal of Oncology 2019 (August 8, 2019): 1–16. http://dx.doi.org/10.1155/2019/9043675.

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Glioblastoma (GBM) is the most aggressive tumor of the central nervous system, and the identification of the mechanisms underlying the biological basis of GBM aggressiveness is essential to develop new therapies. Due to the low prognosis of GBM treatment, different clinical studies are in course to test the use of histone deacetylase inhibitors (iHDACs) in anticancer cocktails. Here, we seek to investigate the impact of HDAC activity on GBM cell behavior and plasticity by live cell imaging. We pharmacologically knock down HDAC activity using two different inhibitors (TSA and SAHA) in two diffe

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Sloan, Anthony, Andrew Sloan, Alok Khorana, et al. "CSIG-19. CANCER STEM CELL MEDIATED F11 DRIVES HYPER-THROMBOTIC ACTIVITY IN GLIOBLASTOMA." Neuro-Oncology 25, Supplement_5 (2023): v44. http://dx.doi.org/10.1093/neuonc/noad179.0175.

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Abstract Cancer-related thrombosis is the second leading cause of death for cancer patients and glioblastoma (GBM), the most common primary malignant brain tumor, is associated with approximately a 30% risk of venous thromboembolism, deep vein thrombosis, or pulmonary embolisms. While this remains a major clinical issue, the interaction between platelets and cancer cells has been underexplored in solid tumor models that do not metastasize, including GBM. GBM is a tumor which contains a high degree of cellular heterogeneity and has populations of therapeutically resistant cancer stem cells (CSC

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Zhai, Kevin, Alena Mazurakova, Lenka Koklesova, Peter Kubatka, and Dietrich Büsselberg. "Flavonoids Synergistically Enhance the Anti-Glioblastoma Effects of Chemotherapeutic Drugs." Biomolecules 11, no. 12 (2021): 1841. http://dx.doi.org/10.3390/biom11121841.

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Flavonoids are polyphenolic plant secondary metabolites with pleiotropic biological properties, including anti-cancer activities. These natural compounds have potential utility in glioblastoma (GBM), a malignant central nervous system tumor derived from astrocytes. Conventional GBM treatment modalities such as chemotherapy, radiation therapy, and surgical tumor resection are beneficial but limited by extensive tumor invasion and drug/radiation resistance. Therefore, dietary flavonoids—with demonstrated anti-GBM properties in preclinical research—are potential alternative therapies. This review

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