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1

Simanov, Daniil, Imre Mellaart-Straver, Irina Sormacheva, and Eugene Berezikov. "The FlatwormMacrostomum lignanoIs a Powerful Model Organism for Ion Channel and Stem Cell Research." Stem Cells International 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/167265.

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Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in regulation of cytoplasmic or vesicular ion concentrations, pH, cell volume, and membrane potentials. Together with ion transporters and gap junction complexes, ion channels form steady-state voltage gradients across the cell membranes in nonexcitable cells. These membrane potentials are involved in regulation of such processes as migration guidance, cell proli
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2

Zadesenets, Kira S., Ilyas Y. Jetybayev, Lukas Schärer, and Nikolay B. Rubtsov. "Genome and Karyotype Reorganization after Whole Genome Duplication in Free-Living Flatworms of the Genus Macrostomum." International Journal of Molecular Sciences 21, no. 2 (2020): 680. http://dx.doi.org/10.3390/ijms21020680.

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The genus Macrostomum represents a diverse group of rhabditophoran flatworms with >200 species occurring around the world. Earlier we uncovered karyotype instability linked to hidden polyploidy in both M. lignano (2n = 8) and its sibling species M. janickei (2n = 10), prompting interest in the karyotype organization of close relatives. In this study, we investigated chromosome organization in two recently described and closely related Macrostomum species, M. mirumnovem and M. cliftonensis, and explored karyotype instability in laboratory lines and cultures of M. lignano (DV1/10, 2n = 10) an
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3

Wasik, Kaja, James Gurtowski, Xin Zhou, et al. "Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano." Proceedings of the National Academy of Sciences 112, no. 40 (2015): 12462–67. http://dx.doi.org/10.1073/pnas.1516718112.

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The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity. Following injury, it can regenerate almost an entirely new organism because of the presence of an abundant somatic stem cell population, the neoblasts. This set of unique properties makes many flatworms attractive organisms for studying the evolution of pathways involved in tissue self-renewal, cell-fate specification, and regeneration. The use of these organisms as models, however, is hampered by the lack of a well-assembled and annotated genome sequences, fundamental to modern genetic and molecular studies
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4

Nimeth, K. "CELL RENEWAL AND APOPTOSIS IN MACROSTOMUM SP. [LIGNANO]." Cell Biology International 26, no. 9 (2002): 801–15. http://dx.doi.org/10.1016/s1065-6995(02)90950-9.

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5

Monties, Bernard. "Composition chimique des bois de chêne: composés phénoliques, relations avec quelques propriétés physiques et chimiques susceptibles d'influencer la qualité des vins et des eaux-de-vie." OENO One 21, no. 3 (1987): 169. http://dx.doi.org/10.20870/oeno-one.1987.21.3.1282.

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<p style="text-align: justify;">Les polyphénols du bois de chêne, extractibles et composés liés à la paroi végétale = lignines, lignanes, tanins et aldéhydes phénoliques, ont été envisagés au niveau moléculaire de leurs relations avec les propriétés physico-chimiques des bois : retrait, porosité, propriétés mécaniques.</p><p style="text-align: justify;">Des résultats originaux ont été aussi présentés concernant le fractionnement des polyphénols pariétaux, l'incrustation des parois par les tanins hydrolysables: acide ellagique associé à des fractions de lignine, ainsi que la f
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6

Mouton, Stijn, Magda Grudniewska, Lisa Glazenburg, Victor Guryev, and Eugene Berezikov. "Resilience to aging in the regeneration-capable flatwormMacrostomum lignano." Aging Cell 17, no. 3 (2018): e12739. http://dx.doi.org/10.1111/acel.12739.

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7

Petti, Marco, Silvia Bosa, Sara Pascolo, and Erika Uliana. "Marano and Grado Lagoon: Narrowing of the Lignano Inlet." IOP Conference Series: Materials Science and Engineering 603, no. 3 (2019): 032066. http://dx.doi.org/10.1088/1757-899x/603/3/032066.

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8

Mouton, Stijn, Maxime Willems, Patricia Back, Bart P. Braeckman, and Gaetan Borgonie. "Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano." Frontiers in Zoology 6, no. 1 (2009): 15. http://dx.doi.org/10.1186/1742-9994-6-15.

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9

De Mulder, Katrien, Georg Kuales, Daniela Pfister та ін. "Potential of Macrostomum lignano to recover from γ-ray irradiation". Cell and Tissue Research 339, № 3 (2010): 527–42. http://dx.doi.org/10.1007/s00441-009-0915-6.

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10

Sefkow, M., M. Raschke, and C. Steiner. "Enantioselective synthesis and biological evaluation of a-hydroxylated lactone lignans." Pure and Applied Chemistry 75, no. 2-3 (2003): 273–78. http://dx.doi.org/10.1351/pac200375020273.

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A short and efficient synthesis of enantiomerically pure α-hydroxylated lactone lignans starting from commercially available diisopropyl malate is presented. Stereoselective alkylation with various benzyl bromides and saponification yielded the corresponding succinic acids. Acetalization afforded the dioxolanones, which were stereoselectively alkylated. Reduction (and deprotection, where required) yielded the lactone lignans in up to 30 % overall yield. The inhibition of the proliferation of HT29 colon cancer cells was investigated. One lignane, bis-2,4,6 trimethylbenzyllactone lignan, was act
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11

Lengerer, Birgit, Julia Wunderer, Robert Pjeta, et al. "Organ specific gene expression in the regenerating tail of Macrostomum lignano." Developmental Biology 433, no. 2 (2018): 448–60. http://dx.doi.org/10.1016/j.ydbio.2017.07.021.

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12

Li, Mi, Yunqiao Pu, Chang Geun Yoo, and Arthur J. Ragauskas. "The occurrence of tricin and its derivatives in plants." Green Chemistry 18, no. 6 (2016): 1439–54. http://dx.doi.org/10.1039/c5gc03062e.

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Review on the occurrence of tricin and its derivatives such as tricin-glycosides, tricin-lignans, and tricin-lignan-glycosides in plants. The recent discovery of tricin incorporated with lignin implies the possible association of lignification and tricin biosynthesis.
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13

Petti, Marco, Silvia Bosa, Sara Pascolo, and Erika Uliana. "An Integrated Approach to Study the Morphodynamics of the Lignano Tidal Inlet." Journal of Marine Science and Engineering 8, no. 2 (2020): 77. http://dx.doi.org/10.3390/jmse8020077.

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The morphological evolution of a tidal inlet is the combined result of tides and wind waves, which interact in a non-linear manner and over very different time-scales. Likewise, the presence of maritime structures built in the vicinity of the tidal inlet, for coastal or port defense or to stabilize the inlet itself, can greatly affect this dynamic equilibrium, changing erosional and depositional patterns of the adjacent shoreline. In this study, the narrowing phenomenon of the Lignano tidal inlet subsequent to the construction of the related port, is examined through an integrated approach in
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14

Mouton, Stijn, Jakub Wudarski, Magda Grudniewska, and Eugene Berezikov. "The regenerative flatworm Macrostomum lignano, a model organism with high experimental potential." International Journal of Developmental Biology 62, no. 6-7-8 (2018): 551–58. http://dx.doi.org/10.1387/ijdb.180077eb.

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15

Willems, Maxime, Frederic Leroux, Myriam Claeys, et al. "Ontogeny of the complex sperm in the macrostomid flatwormMacrostomum lignano(Macrostomorpha, Rhabditophora)." Journal of Morphology 270, no. 2 (2009): 162–74. http://dx.doi.org/10.1002/jmor.10675.

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16

Willems, Maxime, Mieke Boone, Marjolein Couvreur, et al. "Use of freeze-cracking in ontogenetic research in Macrostomum lignano (Macrostomida, Rhabditophora)." Development Genes and Evolution 219, no. 5 (2009): 273–79. http://dx.doi.org/10.1007/s00427-009-0284-x.

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17

Weber, Michael, Athina Giannakara, and Steven A. Ramm. "Seminal fluid‐mediated fitness effects in the simultaneously hermaphroditic flatworm Macrostomum lignano." Ecology and Evolution 9, no. 24 (2019): 13889–901. http://dx.doi.org/10.1002/ece3.5825.

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18

Mansikkala, Tuomas, Minna Patanen, Anna Kärkönen, et al. "Lignans in Knotwood of Norway Spruce: Localisation with Soft X-ray Microscopy and Scanning Transmission Electron Microscopy with Energy Dispersive X-ray Spectroscopy." Molecules 25, no. 13 (2020): 2997. http://dx.doi.org/10.3390/molecules25132997.

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Lignans are bioactive compounds that are especially abundant in the Norway spruce (Picea abies L. Karst.) knotwood. By combining a variety of chromatographic, spectroscopic and imaging techniques, we were able to quantify, qualify and localise the easily extractable lignans in the xylem tissue. The knotwood samples contained 15 different lignans according to the gas chromatography-mass spectrometry analysis. They comprised 16% of the knotwood dry weight and 82% of the acetone extract. The main lignans were found to be hydroxymatairesinols HMR1 and HMR2. Cryosectioned and resin-embedded ultrath
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19

Kuales, Georg, Katrien De Mulder, Jade Glashauser, et al. "Boule-like genes regulate male and female gametogenesis in the flatworm Macrostomum lignano." Developmental Biology 357, no. 1 (2011): 117–32. http://dx.doi.org/10.1016/j.ydbio.2011.06.030.

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20

De Miguel-Bonet, Maria Del Mar, Sally Ahad, and Volker Hartenstein. "Role of neoblasts in the patterned postembryonic growth of the platyhelminth Macrostomum lignano." Neurogenesis 5, no. 1 (2018): e1469944. http://dx.doi.org/10.1080/23262133.2018.1469944.

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21

Verdoodt, Freija, Maxime Willems, Stijn Mouton, et al. "Stem Cells Propagate Their DNA by Random Segregation in the Flatworm Macrostomum lignano." PLoS ONE 7, no. 1 (2012): e30227. http://dx.doi.org/10.1371/journal.pone.0030227.

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22

Mouton, Stijn, Maxime Willems, Bart P. Braeckman, et al. "The free-living flatworm Macrostomum lignano: A new model organism for ageing research." Experimental Gerontology 44, no. 4 (2009): 243–49. http://dx.doi.org/10.1016/j.exger.2008.11.007.

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23

Nimeth, Katharina Theresia, Bernhard Egger, Reinhard Rieger, Willi Salvenmoser, Roland Peter, and Robert Gschwentner. "Regeneration in Macrostomum lignano (Platyhelminthes): cellular dynamics in the neoblast stem cell system." Cell and Tissue Research 327, no. 3 (2006): 637–46. http://dx.doi.org/10.1007/s00441-006-0299-9.

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24

Rivera-Ingraham, G. A., U. Bickmeyer, and D. Abele. "The physiological response of the marine platyhelminth Macrostomum lignano to different environmental oxygen concentrations." Journal of Experimental Biology 216, no. 14 (2013): 2741–51. http://dx.doi.org/10.1242/jeb.081984.

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25

Ma, Yuanyuan, Georgina Rivera-Ingraham, Aude Nommick, Ulf Bickmeyer, and Thomas Roeder. "Copper and cadmium administration induce toxicity and oxidative stress in the marine flatworm Macrostomum lignano." Aquatic Toxicology 221 (April 2020): 105428. http://dx.doi.org/10.1016/j.aquatox.2020.105428.

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26

Zhou, Xin, Giorgia Battistoni, Osama El Demerdash, et al. "Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatwormMacrostomum lignano." RNA 21, no. 11 (2015): 1885–97. http://dx.doi.org/10.1261/rna.052456.115.

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27

Sekii, Kiyono, Willi Salvenmoser, Katrien De Mulder, Lukas Scharer, and Peter Ladurner. "Melav2, an elav-like gene, is essential for spermatid differentiation in the flatworm Macrostomum lignano." BMC Developmental Biology 9, no. 1 (2009): 62. http://dx.doi.org/10.1186/1471-213x-9-62.

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28

Morris, Joshua, Peter Ladurner, Reinhard Rieger, et al. "The Macrostomum lignano EST database as a molecular resource for studying platyhelminth development and phylogeny." Development Genes and Evolution 216, no. 11 (2006): 695–707. http://dx.doi.org/10.1007/s00427-006-0098-z.

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29

Demircan, Turan, and Eugene Berezikov. "The Hippo Pathway Regulates Stem Cells During Homeostasis and Regeneration of the Flatworm Macrostomum Lignano." Stem Cells and Development 22, no. 15 (2013): 2174–85. http://dx.doi.org/10.1089/scd.2013.0006.

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30

Bolvig, Anne Katrine, Herman Adlercreutz, Peter Kappel Theil, Henry Jørgensen, and Knud Erik Bach Knudsen. "Absorption of plant lignans from cereals in an experimental pig model." British Journal of Nutrition 115, no. 10 (2016): 1711–20. http://dx.doi.org/10.1017/s0007114516000829.

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AbstractPlant lignans are diphenolic compounds ingested with whole grains and seeds and converted to enterolignans by the colonic microbiota. In the present study, we investigated absorption and metabolism of plant lignans and enterolignansin vivoafter consumption of cereal-based diets. Six pigs fitted with catheters in the mesenteric artery and portal vein and with a flow probe attached to the portal vein along with twenty pigs for quantitative collection of urine were used for this study. The animals were fed bread based on wheat flour low in plant lignans and three lignan-rich breads based
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31

Yamauchi, Satoshi, Yasuka Yamashita, Asuka Nishimoto, and Hisashi Nishiwaki. "Effects of Substituents on the Aromatic Ring of Lignano-9,9′-lactone on Plant Growth Inhibitory Activity." Journal of Agricultural and Food Chemistry 66, no. 17 (2018): 4551–58. http://dx.doi.org/10.1021/acs.jafc.8b01948.

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32

Azlan, Azali, Mardani Abdul Halim, and Ghows Azzam. "Genome-wide identification and characterization of long intergenic noncoding RNAs in the regenerative flatworm Macrostomum lignano." Genomics 112, no. 2 (2020): 1273–81. http://dx.doi.org/10.1016/j.ygeno.2019.07.016.

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33

Egger, B., and S. Ishida. "Chromosome fission or duplication in Macrostomum lignano (Macrostomorpha, Plathelminthes) - remarks on chromosome numbers in 'archoophoran turbellarians'." Journal of Zoological Systematics and Evolutionary Research 43, no. 2 (2005): 127–32. http://dx.doi.org/10.1111/j.1439-0469.2005.00300.x.

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34

Verdoodt, Freija, Wim Bert, Marjolein Couvreur, Katrien De Mulder, and Maxime Willems. "Proliferative response of the stem cell system during regeneration of the rostrum in Macrostomum lignano (Platyhelminthes)." Cell and Tissue Research 347, no. 2 (2012): 397–406. http://dx.doi.org/10.1007/s00441-011-1299-y.

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35

Esperandim, Viviane Rodrigues, Daniele da Silva Ferreira, Juliana Saraiva, et al. "Reduction of parasitism tissue by treatment of mice chronically infected with Trypanosoma cruzi with lignano lactones." Parasitology Research 107, no. 3 (2010): 525–30. http://dx.doi.org/10.1007/s00436-010-1885-z.

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36

Ustyantsev, K. V., V. Yu Vavilova, A. G. Blinov, and E. V. Berezikov. "Macrostomum lignano as a model to study the genetics and genomics of parasitic flatworms." Vavilov Journal of Genetics and Breeding 25, no. 1 (2021): 108–16. http://dx.doi.org/10.18699/vj21.013.

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37

Sujan, SMA, MA Kashem, and ANM Fakhruddin. "Lignin: a valuable feedstock for biomass pellet." Bangladesh Journal of Scientific and Industrial Research 55, no. 1 (2020): 83–88. http://dx.doi.org/10.3329/bjsir.v55i1.46735.

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Pelletization and briquettization have been extensively used for mass and energy densification of biomass. As the demand for pellets increases, the biorefinery waste lignin can be used with the conventional raw materials for pellet preparation. Sugarcane bagasse (20-40 mesh) is treated with NaOH (8% & 16%) for bioethanol production and obtained lignin is used to prepare pellet along and with sugarcane bagasse (SB). SB, Lignin1 (8% NaOH treated SB), Lignin2 (16% NaOH treated SB) and various composition of SB and Lignin1 were used to produce pelletswith different applied pressures (5kN, 10kN
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38

Huh, Jungmoo, Chang-Min Lee, Seoyoung Lee, Soeun Kim, Namki Cho, and Young-Chang Cho. "Comprehensive Characterization of Lignans from Forsythia viridissima by UHPLC-ESI-QTOF-MS, and Their NO Inhibitory Effects on RAW 264.7 Cells." Molecules 24, no. 14 (2019): 2649. http://dx.doi.org/10.3390/molecules24142649.

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Lignans are known to be an important class of phenylpropanoid secondary metabolites. In the course of our studies on the chemodiversity of lignans, the necessity arose to develop a method for the fast detection and identification of bioactive lignan subclasses. In this study, we detected 10 lignan derivatives of different extracts of F. viridissima by UHPLC-ESI-QTOF-MS. Lignan glycosides (1 and 2), lignans (3 and 4), and lignan dimers (5–10) were identified by analysis of their exact masses and MSe spectra along with the characteristic mass fragmentation patterns and molecular formulas. We fur
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39

Pfister, Daniela, Katrien De Mulder, Volker Hartenstein, et al. "Flatworm stem cells and the germ line: Developmental and evolutionary implications of macvasa expression in Macrostomum lignano." Developmental Biology 319, no. 1 (2008): 146–59. http://dx.doi.org/10.1016/j.ydbio.2008.02.045.

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40

Weber, Michael, Bahar Patlar, and Steven A. Ramm. "Effects of two seminal fluid transcripts on post‐mating behaviour in the simultaneously hermaphroditic flatworm Macrostomum lignano." Journal of Evolutionary Biology 33, no. 5 (2020): 714–26. http://dx.doi.org/10.1111/jeb.13606.

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41

Morris, Joshua, Albert Cardona, Maria Del Mar De Miguel-Bonet, and Volker Hartenstein. "Neurobiology of the basal platyhelminth Macrostomum lignano: map and digital 3D model of the juvenile brain neuropile." Development Genes and Evolution 217, no. 8 (2007): 569–84. http://dx.doi.org/10.1007/s00427-007-0166-z.

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42

Schärer, Lukas, Dagmar Knoflach, Dita B. Vizoso, Gunde Rieger, and Ursula Peintner. "Thraustochytrids as novel parasitic protists of marine free-living flatworms: Thraustochytrium caudivorum sp. nov. parasitizes Macrostomum lignano." Marine Biology 152, no. 5 (2007): 1095–104. http://dx.doi.org/10.1007/s00227-007-0755-4.

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43

Andargie, Mebeaselassie, Maria Vinas, Anna Rathgeb, Evelyn Möller, and Petr Karlovsky. "Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review." Molecules 26, no. 4 (2021): 883. http://dx.doi.org/10.3390/molecules26040883.

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Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans. Sesamol, sesaminol, its epimers, and episesamin are transformation products found in processed products. Synthetic routes to all lignans are known but only sesamol is synthesized industrially. Biosynthesis of furofuran lignans begins with the dimerization of coniferyl alcohol, followed by the formation of dioxoles, oxidation, and glycosylation. Most genes of the lignan pathway in sesame have been identified but the inheritance of lignan content is poorly understood. Health-promoting properties make lignans a
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44

Oestmann, Peter. "Brix, Thomas , Ein unbekanntes Rechtsgutachten von Felinus Sandeus über die Auslegung des Testaments des Juristen Johannes de Lignano." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 135, no. 1 (2018): 467–69. http://dx.doi.org/10.26498/zrgga-2018-1350134.

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45

Willems, Maxime, An-Sofie Stevens, Els Adriaens, et al. "An Adult Stem Cell Proliferation Assay in the Flatworm Model Macrostomum lignano to Predict the Carcinogenicity of Compounds." Applied In Vitro Toxicology 1, no. 3 (2015): 213–19. http://dx.doi.org/10.1089/aivt.2015.0011.

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46

Beltrame, Carlo, and Dario Gaddi. "Report on the first research campaign on the Napoleonic brick,Mercure, wrecked off Lignano, Udine, Italy in 1812." International Journal of Nautical Archaeology 31, no. 1 (2002): 60–73. http://dx.doi.org/10.1111/j.1095-9270.2002.tb01400.x.

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47

Beltrame, C. "Report on the first research campaign on the Napoleonic brick, Mercure, wrecked off Lignano, Udine, Italy in 1812." International Journal of Nautical Archaeology 31, no. 1 (2002): 60–73. http://dx.doi.org/10.1006/ijna.2002.1016.

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48

Petti, Marco, Sara Pascolo, Silvia Bosa, Erika Uliana, and Matteo Faggiani. "Sea defences design in the vicinity of a river mouth: the case study of Lignano Riviera and Pineta." IOP Conference Series: Materials Science and Engineering 603 (September 18, 2019): 032067. http://dx.doi.org/10.1088/1757-899x/603/3/032067.

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49

Willems, Maxime, Bernhard Egger, Carsten Wolff, et al. "Embryonic origins of hull cells in the flatworm Macrostomum lignano through cell lineage analysis: developmental and phylogenetic implications." Development Genes and Evolution 219, no. 8 (2009): 409–17. http://dx.doi.org/10.1007/s00427-009-0304-x.

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50

Rodríguez-García, Carmen, Cristina Sánchez-Quesada, Estefanía Toledo, Miguel Delgado-Rodríguez, and José Gaforio. "Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?" Molecules 24, no. 5 (2019): 917. http://dx.doi.org/10.3390/molecules24050917.

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Dietary guidelines universally advise adherence to plant-based diets. Plant-based foods confer considerable health benefits, partly attributable to their abundant micronutrient (e.g., polyphenol) content. Interest in polyphenols is largely focused on the contribution of their antioxidant activity to the prevention of various disorders, including cardiovascular disease and cancer. Polyphenols are classified into groups, such as stilbenes, flavonoids, phenolic acids, lignans and others. Lignans, which possess a steroid-like chemical structure and are defined as phytoestrogens, are of particular
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