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Dissertations / Theses on the topic 'Limb bone'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Suliman, Isam Ahmed. "Neuromuscular effects related to hind limb disuse : experimental studies in the rat /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3786-9/.

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2

Smith, Caitlin Caryl Danielle. "Giraffa camelopardalis: limb bone histology through ontogeny." Master's thesis, Faculty of Science, 2020. http://hdl.handle.net/11427/32351.

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Although there are many studies on mammalian bone histology, there are only a few that have examined the bone histology of artiodactyls, or focused specifically on osteohistological changes during ontogeny. The current study investigates the microanatomy and histology of giraffe limb bones through ontogeny. Mid-diaphyseal sections of humeri, radii, metacarpals, femora, and tibiae of 14 individuals representing individuals of known sex, as well as at different ontogenetic stages (foetal, juveniles, subadults, and adults). Thin sections were prepared for all the bones, and microanatomical (using

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3

Lloyd, Brandon R. "Comparison of Bone Marrow Mesenchymal Stem Cells from Limb and Jaw Bones." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1458678153.

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4

Newcombe, Lindsay Kathleen. "Biomechanics of limb prostheses directly attached to bone." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/1443994/.

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The technique of attaching a limb directly to the skeleton has clear benefits, when compared with socket-attachment, for the many amputees who encounter skin problems. A potential risk of attaching a limb to the skeleton is the wound where the implant breaches the skin. At the Centre for Biomedical Engineering in the Institute of Orthopaedics and Musculoskeletal Science at UCL, a method has been devised which enhances epithelial attachment to the implant, resisting infection, and this has been used to develop a system for attaching a limb to the skeleton: Intraosseous Transcutaneous Amputation

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5

Mahoney, Emilia. "Molecular Alterations in Bone Development and Bone Tumorigenesis." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243957525.

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6

Lalonde, Robert. "Mechanisms of Appendicular Dermal Bone Loss and Endochondral Bone Expansion during the Fin-To-Limb Transition." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37988.

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The evolution of the tetrapod limb from paired fish fins involved drastic changes to the appendicular dermal and endochondral skeleton. Fish fin rays were lost, and the endochondral bone was modified and elaborated to form three distinct segments common to all tetrapod limbs: the stylopod, the zeugopod, and the autopod. Identifying the molecular mechanisms that contributed to these morphological changes presents a unique insight into our own evolutionary history. Chapter II of this thesis focuses on the actinodin gene family and how their disappearance from the tetrapod genome during the fin-t

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7

Forbes-Robertson, Sarah Anne Natasha. "Structure and expression of the chicken bone morphogenetic protein-2 gene." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244093.

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8

Yamanaka, Atsushi. "Biomechanical Investigation of Anthropoid Limb Bone Morphology in Terms of Bending Strength." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/149551.

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9

Kinsella, Elaine. "Investigation of the E3 ubiquitin ligase UBR5, a novel regulator of Hh gene expression." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21106.

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The Hedgehog (Hh) signalling pathway is essential for embryogenesis and regulating cellular homeostasis in the adult, however much remains unknown about the molecular mechanisms that control ligand expression. In 2002, Lee et al. demonstrated that conditional mutation of the Drosophila hyperplastic discs gene (hyd) resulted in increased hh levels, suggesting that Hyd can act as a negative regulator of hh gene expression. Based on this evidence, the aim of this project was to investigate the hypothesis that UBR5, the murine homologue of Hyd, acts as a novel regulator of Hh gene expression in ma

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10

Bell, Johanna C. "Methodology for Quantifying Biomechanical Bone Movement of Transtibial Amputations." Wright State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=wright1166490962.

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11

Henderson, Donald Mackenzie. "A mathematical and computational analysis of the biomechanics of walking theropod dinosaurs." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297709.

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12

Sinclair, Rhona Ann. "Pre-clinical evaluation of the forces during limb lengthening using manual and automated devices." Thesis, Brunel University, 2011. http://bura.brunel.ac.uk/handle/2438/7669.

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Limb lengthening procedures use fixation devices to extend the constantly regenerating bone and surrounding soft tissues. Automated devices have been developed that aim to provide a more gradual tissue extension, resulting in better quality of treatment for the patient. Benefits include pain reduction and probable enhanced tissue outcomes. The development of one such new smart lengthening device is described. An integrated numerical model of tissue mechanics during lengthening is presented. It represents the mechanical environment in which the devices extend. The mechanism of the automated dev

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13

Björnsdóttir, Sigrídur. "Bone spavin in Icelandic horses : aspects of predisposition, pathogenesis and prognosis /." Uppsala : Dept. of Clinical Radiology, Swedish Univ. of Agricultural Sciences ([Institutionen för klinisk radiologi], Sveriges lantbruksuniv, 2002. http://epsilon.slu.se/avh/2002/91-576-6382-3.pdf.

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14

Serrat, Maria A. "Environmentally-determined tissue temperature modulates extremity growth in mammals a potential comprehensive explanation of Allen's Rule /." [Kent, Ohio] : Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1185486409.

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Thesis (Ph.D.)--Kent State University, 2007.<br>Title from PDF t.p. (viewed Mar. 5, 2009). Advisor: C. Owen Lovejoy. Keywords: temperature, bone growth, Allen's Rule, skeletal morphology, limb proportions, environmental effects on bone growth. Includes bibliographical references (p. 157-176).

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15

Eggert, Donna Marie. "Case Study Analysis Of Osseointegration And Limb-Salvaging Technology In Animal Subject's Bilateral Osseointegrated Implant Journey With Potential Human Translation." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/332675.

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In the twenty-first century, new cutting-edge osseointegration technology is improving quality of life. Osseointegration is a new technique to suspend an implant prosthetic device for individuals with a limb-loss. The science of osseointegration is not clearly understood although there appears to be a special relationship between pure titanium that promotes activation of our bone building cells and bone remodeling. Direct bone-anchored osseointegration to integrate a foreign device into the body without the body rejecting the prosthesis is the new technology lacking knowledge and research clin

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16

Uhrig, Brent A. "Tissue regeneration in composite injury models of limb trauma." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/49080.

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Severe extremity trauma often involves significant damage to multiple tissue types, including bones, skeletal muscles, peripheral nerves, and blood vessels. Such injuries present unique challenges for reconstruction, and improving structural and functional outcomes of intervention remains a pressing, unmet clinical need. While tissue engineering/regenerative medicine (TE/RM) therapeutics offer promising potential to overcome the status quo limitations of surgical reconstruction, very few products have transitioned to clinical practice. Improving treatment options will likely require advanci

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17

Mastrandrea, Carmelo. "The Role of Bone Marrow Adipose Tissue on Unloading-Induced Bone Losses in a Mouse Model." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSES046.

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Chez la souris, la suspension par la queue (SUSP, mise en décharge des membres postérieurs) induit une perte osseuse trabéculaire et corticale liée a une augmentation de la résorption ostéoclastique. dans ce modèle, une expansion de l’adiposité médullaire (BMA) a été démontrée dans des études en microgravité lors d’un vol spatial, suggérant des interactions entre BMA et métabolisme osseux. cependant, des données récentes indiquent que les modifications osseuses de la SUSP pourraient être liées à celles du métabolisme énergétique induit par la SUSP. Dans ce contexte, nous avons utilise les sour

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18

Duvall, Craig Lewis. "The Role of Osteopontin in Postnatal Vascular Growth: Functional Effects in Ischemic Limb Collateral Vessel Formation and Long Bone Fracture Healing." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14567.

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Postnatal vascular growth is a complex process involving multiple cells types whose functionality is orchestrated by a variety of soluble extracellular growth factors, mechanical stimuli, and matrix derived cues. The central goal for this dissertation project was to elucidate the role of osteopontin, a non-collagenous extracellular matrix protein, in postnatal vascular growth. At the onset, we concluded that the current methods for measurement of vascularity in small animal models were lacking. To address this shortcoming, we pursued micro-CT imaging for analysis of three-dimensio

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19

Duvall, Craig L. "The Role of osteopontin in postnatal vascular growth functional effects in ischemic limb collateral vessel formation and long bone fracture healing /." Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-01102007-130423/.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2007.<br>David Harrison, Committee Member ; Ravi Bellamkonda, Committee Member ; Larry McIntire, Committee Member ; Oskar Skrinjar, Committee Member ; W. Robert Taylor, Committee Chair ; Robert Guldberg, Committee Chair.

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20

Monsell, F. P. "The effect of cytotoxic chemotherapy on the structural and material properties of regenerate bone in a rabbit model of limb lengthening." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1306767/.

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Abstract: A New Zealand White (NZW) rabbit model was used to investigate the effect of cyclical cytotoxic chemotherapy on the structural and material properties of regenerate bone. This attempted to reproduce the biological situation encountered in a human adolescent with a primary malignant bone tumour, treated by surgical resection and either adjuvant or neo-adjuvant cyclical chemotherapy with bone transport to reconstruct the skeletal defect. General Hypothesis It is possible to produce normal bone by distraction osteogenesis in the presence of cyclical cytotoxic therapy. Materials and Meth

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21

Wright, Kathryn M. "Loading mechanics in femora of tiger salamanders (Ambystoma tigrinum) and tegu lizards (Tupinambis merianae) implications for the evolution of limb bone design /." Connect to this title online, 2008. http://etd.lib.clemson.edu/documents/1220474405/.

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22

Noble, Garrett John. "Evaluation of a Press Fit, Percutaneous, Skeletally Anchored Endoprosthesis for Prosthetic Limb Attachment: Bone Response and the Effect of Low Intensity Vibration." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437649394.

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23

Onodera, Rie. "Bone marrow mononuclear cells versus G-CSF-mobilized peripheral blood mononuclear cells for treatment of lower limb ASO: pooled analysis for long-term prognosis." Kyoto University, 2010. http://hdl.handle.net/2433/131879.

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24

Liodakis, Emmanouil [Verfasser], and Stefan [Mitwirkender] Hankemeier. "Monorail technique or external fixators for segmental bone defects of the lower limb? : Long term follow-up of 50 cases / Emmanouil Liodakis. Stefan Hankemeier. Unfallchirurgischen Klinik der Medizinischen Hochschule Hannover." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2010. http://d-nb.info/1004469675/34.

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25

Layman, Hans Richard William. "Tissue Engineering Strategies for the Treatment of Peripheral Vascular Diseases." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/461.

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Peripheral vascular diseases such as peripheral artery disease (PAD) and critical limb ischemia (CLI) are growing at an ever-increasing rate in the Western world due to an aging population and the incidence of type II diabetes. A growing economic burden continues because these diseases are common indicators of future heart attack or stroke. Common therapies are generally limited to pharmacologic agents or endovascular therapies which have had mixed results still ending in necrosis or limb loss. Therapeutic angiogenic strategies have become welcome options for patients suffering from PAD due

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26

Trieb, Alicia, and Jennie Lönnesjö. "Lim i skor : Vattenbaserade lim som ett mindre riskfyllt alternativ till lösningsbaserade lim." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-23492.

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NilsonGroup presenterade uppdraget att undersöka vattenbaserade lim som alternativ till lösningsbaserade lim vid tillverkning av skor, vilket var grunden till det här arbetets ämne och avgränsningar har tagits fram. Vattenbaserade lim är ett alternativ till lösningsbaserade lim som inte är lika hälsofarligt, då lösningsmedelkan orsaka allvarliga hälsoeffekter. Enligt NilsonGroup ligger skobranschen steget efter vad det gäller hållbarhet och i nuläget saknas det en satsning på hållbarutveckling, medan andra branscher är bättre på att leta efter nya möjligheter. Det här arbetet vill lyfta fram p

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27

Fincke, Jonathan Randall. "Non-contact quantitative imaging of limbs, bone and tissue, using ultrasound tomographic techniques." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119342.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 123-131).<br>Non-contact and quantitative ultrasound images of bone and soft tissue are produced from original algorithms applied to observational data sets collected on two custom built ultrasound imaging systems for limb imaging. The images are quantitative in that the distribution of sound speeds and dimensionally accurate geometry of tissue structures are reconstructed. The first imaging system is based on

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28

Zhou, Zhaoxia. "Development of bond strength in hydraulic lime mortared brickwork." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550613.

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The first recorded use of hydraulic lime in construction can be traced back to at least two thousand years ago. Hydraulic lime, produced through either adding pozzolanic materials or calcining clay containing limestone, unlike air lime, can set and harden under water, developing strength through initial hydration reaction and subsequent carbonation. After WWII Portland cement mortars had almost completely replaced lime based mortars in modern construction. However, through conservation and specialist construction the benefits of hydraulic lime are becoming increasingly recognised. To support w

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29

McCrady, Shelly. "Response surface analysis of rat bone composition changes by dietary calcium and silicon." Online version, 2003. http://www.uwstout.edu/lib/thesis/2003/2003mccradys.pdf.

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30

Reese, Nathaniel E. "The Ecomorphology of White-tailed Deer Lower Limb Bones Through the Holocene in Central North America." Thesis, Southern Illinois University at Edwardsville, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1589560.

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<p> Recent studies have used ecomorphological methods to look at morphological variation in artiodactyl postcranial elements as indicators of paleoenvironment conditions. From these studies, a continuum of variations in the lower limb bones of members of Bovidae and Cervidae in association with habitat conditions have been developed. The focus of this study is to look at variation in a single species, white-tailed deer (<i>Odocoileus virginianus</i>), that occupies a wide range of habitats and determine if regional adaptations exist in populations of different habitat conditions. </p><p> Thi

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31

Okita, Yusuke. "Compensation by nonoperated joints in the lower limbs during walking after endoprosthetic knee replacement following bone tumor resection." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188714.

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32

Humphrey, Kristen. "Relationship between functional performance and bone mineral density of various skeletal sites in overweight postmenopausal women." Tallahassee, Fla. : Florida State University, 2008. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/341817.

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Thesis (Honors paper)--Florida State University, 2008.<br>Advisor: Dr. Jasminka Ilich-Ernst, Florida State University, College of Arts and Sciences, Dept. of Nutrition, Food and Exercise Sciences. Includes bibliographical references.

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33

Mossor, Angela. "A Horse of a Different Color?: Material Strength and Elasticity of Bones and Tendons in Sloth Limbs." Youngstown State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1597166028044999.

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34

Castro, Tomaylla Rosa María. "Vínculo afectivo en parejas de adultos mayores de Lima y Callao." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/652043.

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.<br>La presente investigación tiene como objetivo describir la manera en la se manifiesta el vínculo afectivo en parejas de adultos mayores de Lima y Callao. Este estudio fue de tipo cualitativo de diseño fenomenológico en él que se utilizó la técnica de entrevista semiestructurada. La muestra estuvo comprendida por 8 parejas de adultos mayores entre 60 a 80 años. Se utilizó el análisis de contenido para establecer las categorías: Contextualización, Expresiones Afectivas, Compromiso de la Pareja y Calidad de la Relación (de manera inductiva y deductiva) con las que se analizó lo expresado por

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35

Portmann, Fabian. "Spectral Inequalities and Their Applications in Quantum Mechanics." Doctoral thesis, KTH, Matematik (Avd.), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-145210.

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The work presented in this thesis revolves around spectral inequalities and their applications in quantum mechanics. In Paper A, the ground state energy of an atom confined to two dimensions is analyzed in the limit when the charge of the nucleus Z becomes very large. The main result is a two-term asymptotic expansion of the ground state energy in terms of Z. Paper B deals with Hardy inequalities for the kinetic energy of a particle in the presence of an external magnetic field. If the magnetic field has a non-trivial radial component, we show that Hardy’s classical lower bound can be improved

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36

ALBUQUERQUE, Maria Luciene Luzia Tavares. "Estratégias de manejo para aclimatar o camarão marinho Litopenaeus vannamei (Boone,1931) à água doce." Universidade Federal Rural de Pernambuco, 2005. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6394.

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Submitted by (edna.saturno@ufrpe.br) on 2017-02-16T13:41:53Z No. of bitstreams: 1 Maria Luciene Luzia Tavares Albuquerque.pdf: 748109 bytes, checksum: ed6d14d8d94e3639f3bb58a2eb31663a (MD5)<br>Made available in DSpace on 2017-02-16T13:41:53Z (GMT). No. of bitstreams: 1 Maria Luciene Luzia Tavares Albuquerque.pdf: 748109 bytes, checksum: ed6d14d8d94e3639f3bb58a2eb31663a (MD5) Previous issue date: 2005-03-01<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Experiments had been carried in the Laboratory of Shrimp culture of the Fishery Department of the Federal Rural

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37

Verdegan, Laura. "Assessment of risk factors for stress fractures and future osteoporosis in female collegiate cross country runners." Menomonie, WI : University of Wisconsin--Stout, 2007. http://www.uwstout.edu/lib/thesis/2007/2007verdeganl.pdf.

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38

Shintcovsk, Ricardo Lima. "Efeito da nicotina na remodelação óssea durante o movimento dentário induzido em ratos : estudo histológico = Nicotine effect upon bone remodeling during orthodontic tooth movement in rats: a histological study / Ricardo Lima Shintcovsk ; orientador, Hiroshi Maruo ; co-orientadora, Maria Ângela Naval Machado." reponame:Biblioteca Digital de Teses e Dissertações da PUC_PR, 2008. http://www.biblioteca.pucpr.br/tede/tde_busca/arquivo.php?codArquivo=1248.

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Dissertação (mestrado) - Pontifícia Universidade Católica do Paraná, Curitiba, 2008<br>Inclui bibliografias<br>O tabaco é considerado o principal fator de risco para o desenvolvimento de doenças cardiovasculares e pulmonares. Não há relatos na literatura que associem a eventual ação da nicotina no movimento dentário induzido. O objetivo deste estudo foi investigar<br>Abstract: Tobacco is considered the main risk factor for developing cardiovascular and lung disease. There are no reports in the literature demonstrating the effect of nicotine on orthodontic movement. The aim of this study was to

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39

Kostíková, Martina. "Návrh testovací figuríny pro nárazové zkoušky." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318116.

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The main objective of this thesis is construction of crash test dummy for vehicle-pedestrian crash tests. There is review of nowadays used crash test dummies types in the introduction of this thesis. This is followed by part describing construction itself. Chapter about construction begins by characterizing of used materials features in relation with real human body physiology. Main part of chapter is describing construction of crash test dummy’s skeleton and its individual components including 3D modelling and strength analysis. Thesis is finished by cost assessment.

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40

Gros, Catherine-Isabelle. "Dysplasie ectodermique hypohidrotique : mise en évidence de nouveaux marqueurs phenotypiques crâniens et post-crâniens chez le mutant Tabby." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ101/document.

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La Dysplasie Ectodermique Hypohidrotique liée à l'X (DEX) est une maladie génétique liée à une mutation du gène EDA. Le phénotype exprimé par le modèle murin Tabby est l'équivalent de celui observé dans l'espèce humaine et présente des anomalies dentaires, cranio-faciales, vertébrales et des défauts de trabéculation osseuse. Dans ce contexte, une cartographie de ces anomalies chez le mutant Tabby était nécessaire et l'analyse de l’impact de la mutation Eda/Ta sur la croissance du squelette crânien et post-crânien a été étudiée. Un suivi longitudinal d'une cohorte d'individus murin Tabby (5 mâl

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Jacqmin, Thibaut. "Mesures de corrélations dans un gaz de bosons unidimensionnel sur puce." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00779447.

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Nous présentons dans ce manuscrit des mesures de corrélations spatiales à un et deux corps effectuées sur un gaz de bosons unidimensionnel et ultra-froid piégé à la surface d'une microstructure. Les corrélations à deux corps sont mises en évidence par des mesures de fluctuations de densité in situ ; les corrélations à un corps sont sondées grâce à des mesures de distributions en impulsion. Nous avons observé des fluctuations de densité sub-poissoniennes dans le régime d'interactions faibles, mettant ainsi en évidence pour la première fois le sous-régime du régime de quasi-condensat dans lequel

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JAPIASSÚ, Pammila. "Estudo do mecanismo de aderência de azulejos e argamassas de cal em revestimentos históricos." Universidade Federal de Goiás, 2011. http://repositorio.bc.ufg.br/tede/handle/tde/1339.

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Made available in DSpace on 2014-07-29T15:18:22Z (GMT). No. of bitstreams: 1 Dissertacao parte 1 Pammila Japiassu.pdf: 6094546 bytes, checksum: 79242a16f08c8b4ca8b8d6b2112d1cda (MD5) Previous issue date: 2011-05-16<br>The historical glazed tiles facades are an important luso-brazilian cultural expression that must be conserved and preserved. The bonding loss of glazed tiles to laying mortars is one of the most critical pathologic manifestations of this kind of coating. However, despite this importance, there‟s still a lack of studies about the bonding mechanism between this historical

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"Functional analysis of Smad1/Smad5 signaling in mouse limb development." 2012. http://library.cuhk.edu.hk/record=b5549490.

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骨形態發生蛋白（BMPs）是調節小鼠發育中肢體的頂外胚層脊（AER）功能和趾間程序性細胞死亡（PCD）的分泌信號。然而這些信號的細胞內第二信使者的身份不明。本研究旨在分析Smad蛋白在受骨形態發生蛋白調節的頂外胚層（AER）功能和趾間程序性細胞死亡的功用和相互作用。基因剔除骨形態發生蛋白信號元件，包括細胞內第二信使者和骨形態發生蛋白，會導致早期胚胎死亡。本研究採用Cre/loxP系統，選擇性地在小鼠發展中肢體的頂外胚層脊和腹側外胚層剔除Smad1和/或Smad5基因。本研究採用Smad1和/或Smad5 floxed等位基因和En1[superscript Cre/]⁺ 敲等位基因。<br>單一選擇性地在發展中肢體的頂外胚層脊和腹側外胚層剔除Smad1或Smad5不會導致肢體畸形。然而，同時選擇性剔除Smad1/Smad5會導致帶子手指和腳趾(syndactyly)。帶子手指和腳趾的形成是因趾間程序性細胞死亡減少和趾間細胞異常增生。 Smad1/Smad5雙突變體的細胞跟踪實驗顯視腹側外胚層增厚和原在腹側的外胚層En1[superscript Cre/]⁺後裔細胞出現異位轉移到背側趾間位置。在分子水平上，Fgf8在Smad1/Smad5雙突變體趾間外胚層的表達延長至胚胎發育的第十三天(E13)。這異位Fgf8表達可作為一個趾間的上皮細胞和間質細胞的生存信號。本研究結果表明，S

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Huang, Wei-Hua, and 黃緯華. "Allogeneic transplantation of hypoxic-cultured bone marrow-derived mesenchymal stem cells ameliorate limb ischemia." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/06072847256961701419.

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博士<br>國立陽明大學<br>口腔生物研究所<br>102<br>Critical limb ischemia (CLI) caused by arterial occlusion often leads to limb necrosis and amputations. One effective therapeutic approach has involved the local injection of stem cells directly into ischemic tissue. Multipotent stromal cells, also termed mesenchymal stem cells (MSCs) are multipotential, ease to isolate, and amenable to ex vivo expansion which represent a promising cell source for ischemic limb autologous cell therapy. MSCs have been applied in neoangiogenesis via incorporation into newly formed vessels and muscle cells. However, the therapeu

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Chen, Lo Wan, and 羅琬真. "Longitudinal Research on Adolescents and Young Adults with Bone Tumor after Limb Salvage Surgery." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/w23mxq.

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碩士<br>國立臺北護理健康大學<br>護理研究所<br>107<br>Background: Surgery is one of the treatment methods for bone tumor, and amputation used to be the predominant surgical method applied. However, the advance in chemotherapy, diagnostic radiology, and surgical techniques has enabled most patients to retain their limbs through limb salvage surgery. Nevertheless, such surgery involves excising a considerable part of the infected bone for tumor removal, after which the damaged bone requires suitable reconstruction. This can substantially affect patients’ muscle strength, joint movement, recovery of limb functions

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Sheng-Min, Kao, and 高聖閔. "Four-Point-Bending Simulation Analysis of Dynamic Compression Bone Plate of Human Lower Limb." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/65512948380701518567.

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碩士<br>正修科技大學<br>機電工程研究所<br>103<br>In Taiwan, there are thirty thousand patients treated long bone fracture every year. The system of bone plate and screws is one of the most commonly treatment method for bone trauma. In addition to bone plate for the fracture fixing also has to share bone’s loading, therefor the bone plate strength is a priority factor for this system design. In this research, based on ASTM F382 standard, a four-point bending test simulation model of the dynamic compression bone plate has been developed for human lower limb by using SolidWorks first. Then through the ANSYS sof

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HUANG, JYUN-Yi, and 黃俊毅. "The Verification of Bending Fatigue Analysis Model for Dynamic Compression Bone Plate of Human Lower Limb." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/39r8qf.

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碩士<br>正修科技大學<br>機電工程研究所<br>105<br>In Taiwan, due to aging population, osteoporosis patients are increasing. According to the statistics of the Department of Health, more and more people are often caused comminuted fracture by car accident, fall etc. Metal bone plate is the most effective treatment used for reconstruction on orthopedic surgery. Since bone plates bears the external force that caused the bone fracture, sufficient strength design is the major factor that determines if the bone plates are able to be implemented in human body. Other than the control of the static properties such as

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Ashe, Maureen Celeste. "Upper limb bone health : cadaveric, imaging and clinical studies with special emphasis on peripheral quantitative computed tomography." Thesis, 2005. http://hdl.handle.net/2429/16996.

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Introduction: Osteoporotic fractures are a major health care problem. A radial fracture is an important risk factor for osteoporosis that should initiate the assessment of bone health. Purpose: 1) To validate pQCT measures of bone in aged cadaveric radii. 2) To examine side-side differences in radial bone variables after disuse. 3) To test a novel intervention for secondary prevention of osteoporosis after an index radial fracture. Methods: Study Design: Part 1: Parts 1A and 1B are descriptive cadaveric studies. Part 2: Cross-sectional observational studies of bone response to disuse; Part 3:

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LIU, XIAO-JING, and 劉曉靜. "The Effects Of Intensive Martial Art Training On Bone Mineral Density And Lower Limb Muscle Strength Of The Elementary School Children." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/25365019310767700622.

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碩士<br>國立臺南大學<br>體育學系體育科教學碩士班<br>105<br>ABSTRACT 　　The study is to investigate the effects of intensive martial art training on bone mineral density and lower limb muscle strength of the elementary school children. Children of intermediate grade from an elementary school in Yunlin county construct two groups of twelve-person: 1) the experimental group, which members receive five times martial art training per week during the twelve-week test period, and 2) the control group, which members do not get any further training except two regular physic education classes every week. In this study, SONO

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"The effectiveness of an educational intervention on pain management and post-operative outcomes of Chinese patients with fracture limb." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074725.

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Aim. The overall aims of this study were to develop a tailor-made educational intervention and to examine its effectiveness on short- and longer-term outcomes among Chinese patients with traumatic limb fractures who had undergone surgery.<br>Background. Fracture limb and undergoing surgery is the common problem after injury. It is the most common source of pain and anxiety and research continues to demonstrate a high prevalence of unrelieved pain in injured patients who have undergone surgery. Patient's belief in pain is the major barrier in pain management. Strategies directed to have appropr

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