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Relevant bibliographies by topics / Limitations of extended-release tablet

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Academic literature on the topic 'Limitations of extended-release tablet'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Limitations of extended-release tablet"

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Chandra, Prakash Sunuwar* Meenakshi Kandwal Shivanand Patil. "A Review on Formulation and Evaluation of Mirabegron Extended-Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4859–65. https://doi.org/10.5281/zenodo.15547921.

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A type of modified-release dosage form known as an extended-release (ER) tablet is designed to release the active pharmaceutical ingredient (API) gradually over a long period of time. The human body metabolizes and excretes drugs at different rates. Fast drug absorption may result in peak plasma concentrations that could be harmful, whereas fast clearance in conventional formulations causes subtherapeutic levels that necessitate frequent dose. Extended-release formulations get around these issues and ensure a long-lasting therapeutic effect by modifying the kinetics of medicine release. This s

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Madhu, Rajak*, Amal Raj A., Singh Dhakad Rajendra, and Singh Rajput Hakim. "FORMULATION AND EVALUATION OF BILAYER TABLET OF ANTIHYPERTENSIVE DRUG." World Journal of Pharmaceutical Science and Research 3, no. 5 (2024): 440–53. https://doi.org/10.5281/zenodo.14050790.

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The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a sustained release layer. The immediate release layer was prepared using super disintegrant sodium starch glycolate and sustained release layer is formulated with different polymers. The bilayer tablets of losartan potassium were prepared by the direct compression method. The drug, polymers and other excipients used for both immediate (IR) and sustained release (SR) layers were passed through sieve #80 before their use in the formulation. The immediate dose of drug was calculated from to

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Galankar, Vipulata P., Ganesh D. Basarkar, Chandrashekhar D. Upasani, and Sunil V. Amrutkar. "Indomethacin-Loaded Nanosponges for Oral Delivery: Formulation Strategy, Optimization, and In-vitro Evaluation." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–07. https://doi.org/10.25258/ijddt.15.2.15.

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Chronic illnesses like arthritis cause pain and inflammation, requiring extended oral analgesic therapy. To reduce adverse reactions, active pharmaceutical ingredients are administered through sustained-release dosage forms. However, methods like matrix tablets, osmotic systems, and ion exchange resins have limitations. Nanotechnological approaches like nanosponges improve precision and accuracy in medication release manufacturing. Encapsulated formulations offer benefits like reduced side effects, varied dose options, non-irritating properties, and aesthetic appeal. Nanosponges are used in fo

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Agale, Karan A., and Sanket Pandurang Shinde. "A Review on Floating Tablet." Journal of Drug Delivery and Therapeutics 15, no. 2 (2025): 204–9. https://doi.org/10.22270/jddt.v15i2.7015.

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Floating drug delivery systems (FDDS) are designed with a lower bulk density than gastric fluids, enabling them to remain buoyant in the stomach for extended periods without affecting the gastric emptying rate. While floating on the stomach's contents, these systems release medication in a controlled and sustained manner. Once the drug is fully released, the system disintegrates or is emptied from the stomach. This mechanism increases the Gastric Residence Time (GRT), leading to improved control over fluctuations in plasma drug concentration. To achieve this, FDDS must possess sufficient struc

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Lee, Sang-Ho, and Joo-Eun Kim. "Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet." Pharmaceutics 13, no. 2 (2021): 259. http://dx.doi.org/10.3390/pharmaceutics13020259.

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The aim of this study was to develop immediate-release oral rabeprazole sodium tablets with rapid efficacy and gastric stability for the treatment of gastroesophageal reflux disease. Rabeprazole sodium is a commonly prescribed proton pump inhibitor; however, it is extremely unstable and degrades in acidic environments. Hence, it has been manufactured and supplied only in enteric-coated tablet form, while immediate-release (IR) formulations for this drug are very limited. In this study, we applied the quality by design (QbD) approach to formulate and optimize an IR dry-coated tablet containing

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Lamkhade, Snehal* Shelke Pranali Dr. Wakale Vijaykumar S. "A Brief Review on Quinine Sulphate Sustained Release Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4558–64. https://doi.org/10.5281/zenodo.15527245.

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Malaria continues to pose a significant global health burden, particularly in developing regions with limited healthcare access. Conventional antimalarial therapies, while effective, suffer from limitations such as short drug half-lives, poor patient compliance, and the rising threat of drug resistance. In response to these challenges, sustained release (SR) tablet formulations are emerging as a promising strategy to optimize antimalarial drug delivery. This review paper presents a comprehensive overview of the formulation approaches, materials used, pharmacokinetic benefits, and clinical impl

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Shrikant, S. Dongare* Mr. Dnyaneshwar S. Vyavhare Dr. Megha T. Salve. "Concept And Recent Advancement In Tablet Coating Technologies: A Comprehensive Review." International Journal in Pharmaceutical Sciences 1, no. 11 (2023): 496–506. https://doi.org/10.5281/zenodo.10207162.

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Tablet coating, an enduring pharmaceutical process, involves the application of a dry outer layer to confer specific benefits on the dosage form, such as taste and odor masking, physical and chemical protection, protects the drug from the gastric surroundings, and control over release profiles. This technique, applicable to various solid oral forms, including particles, powders, granules, crystals, pellets, and tablets, employs a sugar or polymeric coat.  Traditional methods, like sugar coating, film coating, and enteric coating, were once prevalent, but recent advancements have circumven

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Kute, Vaibhav Ghansham, Rajeshwari Satish Patil, Vaishnavi Ghansham Kute, and Priti Dilip Kaluse. "Immediate-release dosage form; focus on disintegrants use as a promising excipient." Journal of Drug Delivery and Therapeutics 13, no. 9 (2023): 170–80. http://dx.doi.org/10.22270/jddt.v13i9.6217.

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Disintegrants are materials or mixtures of substances added in the drug formulations, which make easier dispersion or breakup of tablets and ingredients of capsules in small-scale particles for fast dissolution then it comes in contact with water in the GI tract. Immediate drug release dosage forms disintegrate rapidly after administration with an enhanced rate of dissolution. The superdisintegrants provide instantaneous disintegration of tablets after administration in the stomach. In this field, immediate-release liquid dosage forms and parenteral dosage forms have also been introduced for t

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Kotame, Radhika N., and Kratika Daniel. "Formulation, Development and Optimization of Silymarin Loaded Nanoparticle Orodispersible Tablets for its Anti-inflammatory Activity." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1722–27. http://dx.doi.org/10.25258/ijddt.14.3.67.

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The objective of this work was to enhance the anti-inflammatory properties of silymarin by developing and refining an orodispersible tablet formulation loaded with nanoparticles. Formulation development and optimization of silymarin-loaded nanoparticle orodispersible tablet for its anti-inflammatory activity is the focus of this research paper. Nanoparticle drug delivery systems can help to overcome these limitations by enhancing solubility and absorption. Disintegration and dissolution of Orodispersible tablets take place in the mouth rapidly without water, providing a faster onset of action.

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Patil, Vinod S., Benjamin C. Burdette, J. Zach Hilt, Douglass S. Kalika та Thomas D. Dziubla. "Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin". Gels 8, № 6 (2022): 337. http://dx.doi.org/10.3390/gels8060337.

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Oral drug delivery remains the most common and well tolerated method for drug administration. However, its applicability is often limited due to low drug solubility and stability. One approach to overcome the solubility and stability limitations is the use of amorphous polymeric prodrug formulations, such as poly(β-amino ester) (PBAE). PBAE hydrogels, which are biodegradable and pH responsive, have shown promising results for the controlled release of drugs by improving the stability and increasing the solubility of these drugs. In this work, we have evaluated the potential use of PBAE prodrug

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Dissertations / Theses on the topic "Limitations of extended-release tablet"

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TILLOTSON, JOHN KING. "DEVELOPMENT AND EVALUATION OF EXTENDED-RELEASE BUMETANIDE TABLETS." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085067185.

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Draganoiu, Elena Simona. "Evaluation Of Kollidon® SR for Ph-Independent Extended Release Matrix Systems." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054756192.

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Peres, Carolina [UNESP]. "Planejamento de estudo clínico para a avaliação da biodisponibilidade comparativa de nova formulação de liberação prolongada de benzonidazol." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151961.

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Submitted by Carolina Peres null (carol_peres88@hotmail.com) on 2017-10-20T13:48:07Z No. of bitstreams: 1 Dissertação completa mestrado.pdf: 3043086 bytes, checksum: 409a3054d7b6e44ea30ba5eca7aac1bf (MD5)<br>Approved for entry into archive by Luiz Galeffi (luizgaleffi@gmail.com) on 2017-10-23T19:13:46Z (GMT) No. of bitstreams: 1 peres_c_me_bot.pdf: 3043086 bytes, checksum: 409a3054d7b6e44ea30ba5eca7aac1bf (MD5)<br>Made available in DSpace on 2017-10-23T19:13:46Z (GMT). No. of bitstreams: 1 peres_c_me_bot.pdf: 3043086 bytes, checksum: 409a3054d7b6e44ea30ba5eca7aac1bf (MD5) Previous issue

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Peres, Carolina. "Planejamento de estudo clínico para a avaliação da biodisponibilidade comparativa de nova formulação de liberação prolongada de benzonidazol." Botucatu, 2017. http://hdl.handle.net/11449/151961.

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Orientador: Rosângela Gonçalves Peccinini<br>Resumo: A doença de Chagas é uma enfermidade que afeta milhões de pessoas no mundo, principalmente em países em desenvolvimento. No Brasil, o único fármaco disponível para tratamento desta doença é o benzonidazol (BNZ). Atualmente o regime posológico para adultos consiste na administração deste fármaco na forma de comprimidos de liberação imediata de 100 mg em duas ou três tomadas diárias, durante 60 dias. Apesar da elevada eficácia desse fármaco na fase aguda da doença (aproximadamente 70%), os eventos adversos são frequentes e muitas vezes causam

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Meneghini, Leonardo Zanchetti. "Desenvolvimento e validação de metodologia analítica para bromidrato de darifenacina comprimido." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/96032.

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O objetivo deste trabalho foi o desenvolvimento e validação de métodos analíticos para determinação do bromidrato de darifenacina (DF) em comprimidos de liberação modificada. Na fase de identificação, a matéria-prima do fármaco (substância química de referência) foi analisada e caracterizada utilizando-se de medidas físicas (ponto de fusão, polarimetria, solubilidade), espectroscopia (infravermelho, ultravioleta-visível, massas) e técnicas cromatográficas (cromatografia a líquido de alta eficiência, cromatografia em camada delgada). Nos estágios posteriores, os experimentos para quantificação

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Li, Shu-Hui, and 李淑惠. "Preparation and Evaluation of Nicardipine HCl Matrix Tablet for Extended Release." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/53508166659912483998.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>92<br>Controlled release may be defined as a technique by which drug are made available to a target at a fixed rate and duration to produce a desirable therapeutic effect. The purpose of the study was to prepare nicardipine matrix for extended release. HPMC was selected as carrier to prepare nicardipine tablets and Sodium alginate and Avicel® were used to confer the release of drug. The response surface methodology (RSM) and multiple responses optimization polynomial equation were used to obtain optimal nicardipine matrix for extended release. First of all the relea

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Books on the topic "Limitations of extended-release tablet"

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Cavacuiti, Christopher. The Pharmacology of Opioids (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190265366.003.0008.

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This chapter focuses on the attributes of and component medications within the class of opioids, emphasizing kinetics, dynamics, and therapeutic and adverse effects. To help patients make informed decisions about opioid use, the clinicians prescribing these medications must be able to explain when opioids are likely to help and when they are likely to do harm. Subclasses of opioids include phenanthrenes, benzomorphans, phenylpiperidines, and diphenylheptanes; examples are given of each, with respective utilities and limitations. A discussion then follows of pharmacodynamics, pharmacokinetics,

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Book chapters on the topic "Limitations of extended-release tablet"

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Pazhayattil, Ajay Babu, and Sanjay Sharma. "Case Study: Dissolution OOT Observed for an Extended-Release Tablet Formulation." In AAPS Introductions in the Pharmaceutical Sciences. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-86504-6_6.

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Navabhatra, A., and B. Yingngam. "Biocompatible Tablet Film Coatings for Active Pharmaceutical Ingredients." In Medical Applications for Biocompatible Surfaces and Coatings. Royal Society of Chemistry, 2024. http://dx.doi.org/10.1039/9781837675555-00076.

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In the pharmaceutical industry, the process of coating tablets with active pharmaceutical ingredients (APIs) poses significant challenges related to biocompatibility and drug efficacy. Traditional coatings often have limitations in terms of their compatibility with the human body, which can lead to decreased bioavailability and adverse reactions. This chapter aims to address these challenges by focusing on the development of biocompatible tablet film coatings that are specifically designed to deliver APIs while also ensuring safety and enhancing patient compliance. The chapter explores the for

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Sunitha, Ramineni, Praveen Sivadasu, and Raghavendra Kumar Gund. "Statistical Optimization and Evaluation of Extended Release Tablets for Divalproex Sodium." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00549.

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The purpose of current experimental research is to optimize the quantities of macromolecules such as EudragitL/100-55, HPMC-K-100M for the development of divalproex sodium extended release tablets. Divalproexsodium, an anticonvulsant or epileptic agent. It was used in the effective management of bipolar disorders, Mania, seizures, convulsions, tremors/epilepsy. Divalproex sodium ER tablets were formulated with the help of EudragitL/100-55 and HPMC-K-100M in variable composition and variable amounts as per 32 factorial design technique. They were prepared by direct compression technique. Quanti

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Dias-Souza, Marcus Vinícius, and Cleiton Gonçalves Dias. "Metal-Organic Frameworks." In Emerging Applications and Implementations of Metal-Organic Frameworks. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4760-1.ch009.

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In the field of bioinorganic chemistry, porosity has been explored for the development of metal-organic frameworks (MOFs), innovative polymers, or networks composed of metal centers that stabilize organic molecules with high contact surface and well-defined crystalline structures. MOFs have also been investigated for drug therapies due to their high loading capacity, thermal stability, low electrical conductivity, biodegradability, biocompatibility, easy functionalization, and size considered adequate to control drug release in vivo. MOFs can be sensitive to variations in pH, magnetism, temper

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Martino Capuzzo, Arnaud, Riccardo Ossanna, Lindsey Alejandra Quintero Sierra, et al. "From the Classification of Stem Cells to the Release of Potential in Cell Therapies: Limits, Considerations and Future Aspects in Regenerative Medicine." In Possibilities and limitations in current translational stem cell research [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.110572.

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Regenerative medicine aims to repair organs or tissues that have congenital abnormalities, or that have been damaged by disease, aging, or trauma, and to restore or at least improve their native function. One of the strategies used in regenerative medicine is stem cell therapy, due to the enormous regenerative potential of stem cells. A staminal cell line is a group of cells that can replicate for an extended period in vitro, that is outside the body. These cells are grown in incubators using a culture medium that should have a temperature and an oxygen/carbon dioxide composition that simulate

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Phukan, Mayuri, Bitu Gogoi, Abhishek Parasar, and Farida Pegu. "RECENT DEVELOPMENTS IN THE MUCOADHESIVE DRUG DELIVERY SYSTEM DOMAIN." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 3. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn3ch7.

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Mucoadhesive drug delivery systems have emerged as a promising approach to enhance the efficacy and specificity of drug administration. In recent years, significant advancements in this domain have expanded the possibilities of targeted drug delivery to mucosal surfaces, revolutionizing the Pharmaceutical field. The utilization of novel mucoadhesive polymers and nanoparticles has paved the way for controlled and sustained drug release, overcoming the limitations of conventional dosage forms. By exploiting the adhesive properties of these formulations, drug bioavailability has been substantiall

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Thakur, Priya, Pooja Kumari, Shital Mahendra Sonawane, and Avinash Kumar Rao Rao. "MICROENCAPSULATION IN PHARMACEUTICAL SCIENCE: UNVEILING THE LIMITATIONS, METHODS, AND APPLICATIONS OF MICROSPHERES, MICROCAPSULES, AND MICROPARTICLES." In Novel Drug Delivery System from Fundamental Principles to Advanced Applications. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurndch3.

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Microencapsulation, a crucial technique in the field of pharmaceutical science, involves enclosing active pharmaceutical ingredients (APIs) within microspheres, microcapsules, or microparticles. This study systematically explores the various facets of microencapsulation, encompassing its definition, advantages, disadvantages, methodologies, and diverse applications in the pharmaceutical sector. The definition section delves into the fundamental concept microencapsulation, elucidating of the process that protects APIs within a protective matrix. The research uncovers advantages such as improved

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Ram*, Dr Darshit, Dr Santosh Kirtane, and Dr Dhara Chavda. "THIN FILMS: NOVEL ASPECTS OF DRUG DELIVERY." In Emerging Pharmaceutical Sciences: Today and Tomorrow. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurch329.

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These days, scientists are concentrating their efforts on creating novel dosage forms for thin films in the pharmaceutical industry. Compared to typical dose forms, thin film has become an uncommon dosage type. Thin film has various benefits, including ease of administration, rapid dose release, and patient convenience, all of which make it an excellent choice for medication delivery. This delivery mechanism has been used via a variety of channels, including transdermal, buccal, ocular and oral for both local and systemic movement. Effective film layout necessitates a thorough understanding of

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Yalcinkaya, D. B., S. Dogan, V. C. Ozalp, and B. Guvenc Tuna. "Targeted Nanocarriers." In Characterisation of Drug Nanocarriers. Royal Society of Chemistry, 2024. https://doi.org/10.1039/9781837672981-00297.

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This chapter provides an overview of targeted nanocarriers in medicine, discussing their significant advancement in drug delivery and focusing on the general characterization methods. Nanocarriers significantly enhance drug delivery efficacy and specificity, addressing the limitations of traditional methods. These carriers are designed to transport therapeutic agents efficiently to targeted sites, with modifications allowing for ligand attachment and the incorporation of various molecules. A key challenge in drug delivery, the rapid fluctuation of drug concentration in the bloodstream, is addr

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Li, Kai, Qing Shao, Peng Zhang, et al. "Model-Based Testing Platform for Coordinated Control of Electromagnetic Suspension, Guidance, and Eddy-Current Braking in High-Speed Maglev Trains." In Advances in Transdisciplinary Engineering. IOS Press, 2025. https://doi.org/10.3233/atde250245.

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The Electromagnetic Suspension (EMS) high-speed maglev system, as a representative intelligent transportation system, employs intelligent electromagnetic attraction control to achieve stable levitation above the track, enabling contactless operation and establishing itself as a next-generation sustainable transport solution. Unlike conventional wheel-rail systems, this intelligent transportation innovation addresses critical challenges including real-time system integration, automated control coordination, and multi-sensor data fusion. The development faces significant technical barriers such

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Conference papers on the topic "Limitations of extended-release tablet"

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Grundy, John, Anthony Blackburn, Ed Parsley, Yong Tang, Christopher King, and John Adams. "Clinical pharmacokinetic (PK) performance of a ralinepag extended-release (XR) tablet." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa3037.

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Anton, Margareta, and Corina Ivan. "COACH`S EYE SOFTWARE USE IN JAVELIN THROWING TECHNIQUE IMPROVEMENT." In eLSE 2015. Carol I National Defence University Publishing House, 2015. http://dx.doi.org/10.12753/2066-026x-15-223.

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The high degree of applicability of various software in high performance athlete training, allows for a more detailed analysis of any technical aspects. It also underlines any deviations, thus improving execution through the addition of specific restructured means. Any trainer whom owns a current generation smart-phone or tablet may download an application known as Coach's Eye for a modest sum. Keeping in mind one must be able with one's fingers, the software may be employed in order to underline various flaws in technique that may appear throughout a certain event. These errors may be address

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Sunzel, Eva-Maria, Laura Rabinovich-Guilatt, Malini Iyengar, et al. "A Bioequivalence Comparison at Steady State between the Newly Developed Once-Daily Extended Release Tablet Formulation and the Approved Twice-Daily Tablet Formulation of Deutetrabenazine (P2-11.015)." In 2023 Annual Meeting Abstracts. Lippincott Williams & Wilkins, 2023. http://dx.doi.org/10.1212/wnl.0000000000202209.

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Mohamed, M.-EF, J. Zeng, I.-H. Song, and AA Othman. "THU0177 ABT-494 pharmacokinetics following administration of the once-daily extended-release tablet formulation being utilized in the ongoing rheumatoid arthritis phase 3 trials." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3224.

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Hansen, Matthew E. "New rainbow holograms with extended viewing angles." In OSA Annual Meeting. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/oam.1987.wq1.

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Two new rainbow holograms avoid the viewing limitations of the slit-master rainbow hologram. These two holograms are the rainbow-master rainbow hologram and the ring-master rainbow hologram. Both holograms are displayed horizontally while white light is reilluminated from directly above or below. The rainbow viewing window of the ring-master rainbow hologram is a truncated cone shape which hovers above and around the horizontal holographic image. This allows for 360° viewing. The rainbow-master rainbow hologram exhibits the same properties with a 180° viewing window. As with the slit-master ra

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Vetter, Daniel, Thomas Hagemann, and Hubert Schwarze. "Potentials and Limitations of an Extended Approximation Method for Nonlinear Dynamic Journal and Thrust Bearing Forces." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-75662.

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Nonlinear dynamic journal bearing modeling within rotordynamic analyses requires the calculation of the nonlinear bearing forces particularly depending on shaft eccentricity and velocity. The bearing forces can be calculated properly using Reynolds differential equation and mass conserving cavitation algorithms, based for example on Elrod’s cavitation algorithm. This approach achieves high model accuracy and allows the consideration of additional effects like misalignment, variable viscosity and transient local oil distribution in the lubricant film. However, despite rising calculating capacit

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Sunzel, Eva-Maria, Giulia Ghibellini, Malini Iyengar, et al. "Assessment of Dose Proportionality of Three Dose Strengths (6 mg, 12 mg and 24 mg) over the Clinical Dose Range (6–48 mg) of the Newly Developed Once-Daily Extended Release Tablet Formulation of Deutetrabenazine (P2-11.016)." In 2023 Annual Meeting Abstracts. Lippincott Williams & Wilkins, 2023. http://dx.doi.org/10.1212/wnl.0000000000202218.

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Lee, Joomyung, Mostafa M. Hamza, Havva Tayfur, Yahya A. Alzahrani, and Mihai A. Diaconeasa. "Probabilistic Risk Assessment Study for Uncertainty Quantification of Spent Pebble-Bed Dry Cask Storage System Operation." In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-117024.

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Abstract The development of on-site interim dry storage systems has become an important issue, not only for existing nuclear power plant (NPP) operations but also for next-generation NPP designs, due to space limitations in the spent fuel pool. To ensure the safety of the spent fuel dry storage system operation, probabilistic risk assessment (PRA) elements are utilized throughout the non-light water reactor (LWR) lifecycle. Uncertainty quantification is an essential aspect to evaluate the risk through PRA performance, particularly in assessing off-site risks associated with advanced NPPs and r

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Wu, Zijie, Peng Chen, Xinhao Zhao, Chao Guo, Dekui Zhan, and Shaoxiong Xia. "Sensitivity and Uncertainty Analysis of Molten Corium-Concrete Interaction (MCCI) for ALWR During Severe Accident." In 2022 29th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/icone29-89217.

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Abstract Molten corium-concrete interaction is an important phenomenon in the late phase of severe accident, threatening the integrity of containment and might causing potential large release of radioactivity. A sensitivity and uncertainty analysis of MCCI under severe accident of a 1000 MW advanced light water reactor (ALWR) was performed with ASTEC (MEDICIS) [1], a lumped parametric integral severe accident code developed by IRSN. Several representative phenomena were screened out referenced by EURSAFE severe accident Phenomena Identification and Ranking Table (PIRT) [2], including debris be

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Azari, Fatemeh, and Robabeh Jazaei. "Advancements and Challenges in Soft Tissue Engineering: A Comprehensive Review of Additive Manufacturing Technologies." In ASME 2024 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2024. https://doi.org/10.1115/imece2024-145980.

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Abstract In contemporary biomedical innovation, Additive Manufacturing (AM) has been pivotal since the 1980s, crafting complex structures for bioengineering, biomedicine, and pharmacology [1]. Particularly in pharmacology, AM, notably through Stereolithography (SLA), has transformed drug delivery, enhanced dosage precision and advancing personalized therapies [2]. In tissue engineering, AM is crucial for bioprinting scaffolds and tissue constructs using bio-inks to mimic human tissues, facilitating significant advances in medical treatments [3]. (i) Key techniques include SLA achieving 30-micr

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