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Journal articles on the topic 'Limitations of extended-release tablet'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chandra, Prakash Sunuwar* Meenakshi Kandwal Shivanand Patil. "A Review on Formulation and Evaluation of Mirabegron Extended-Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4859–65. https://doi.org/10.5281/zenodo.15547921.

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A type of modified-release dosage form known as an extended-release (ER) tablet is designed to release the active pharmaceutical ingredient (API) gradually over a long period of time. The human body metabolizes and excretes drugs at different rates. Fast drug absorption may result in peak plasma concentrations that could be harmful, whereas fast clearance in conventional formulations causes subtherapeutic levels that necessitate frequent dose. Extended-release formulations get around these issues and ensure a long-lasting therapeutic effect by modifying the kinetics of medicine release. This s

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2

Madhu, Rajak*, Amal Raj A., Singh Dhakad Rajendra, and Singh Rajput Hakim. "FORMULATION AND EVALUATION OF BILAYER TABLET OF ANTIHYPERTENSIVE DRUG." World Journal of Pharmaceutical Science and Research 3, no. 5 (2024): 440–53. https://doi.org/10.5281/zenodo.14050790.

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The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a sustained release layer. The immediate release layer was prepared using super disintegrant sodium starch glycolate and sustained release layer is formulated with different polymers. The bilayer tablets of losartan potassium were prepared by the direct compression method. The drug, polymers and other excipients used for both immediate (IR) and sustained release (SR) layers were passed through sieve #80 before their use in the formulation. The immediate dose of drug was calculated from to

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Galankar, Vipulata P., Ganesh D. Basarkar, Chandrashekhar D. Upasani, and Sunil V. Amrutkar. "Indomethacin-Loaded Nanosponges for Oral Delivery: Formulation Strategy, Optimization, and In-vitro Evaluation." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–07. https://doi.org/10.25258/ijddt.15.2.15.

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Chronic illnesses like arthritis cause pain and inflammation, requiring extended oral analgesic therapy. To reduce adverse reactions, active pharmaceutical ingredients are administered through sustained-release dosage forms. However, methods like matrix tablets, osmotic systems, and ion exchange resins have limitations. Nanotechnological approaches like nanosponges improve precision and accuracy in medication release manufacturing. Encapsulated formulations offer benefits like reduced side effects, varied dose options, non-irritating properties, and aesthetic appeal. Nanosponges are used in fo

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Agale, Karan A., and Sanket Pandurang Shinde. "A Review on Floating Tablet." Journal of Drug Delivery and Therapeutics 15, no. 2 (2025): 204–9. https://doi.org/10.22270/jddt.v15i2.7015.

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Floating drug delivery systems (FDDS) are designed with a lower bulk density than gastric fluids, enabling them to remain buoyant in the stomach for extended periods without affecting the gastric emptying rate. While floating on the stomach's contents, these systems release medication in a controlled and sustained manner. Once the drug is fully released, the system disintegrates or is emptied from the stomach. This mechanism increases the Gastric Residence Time (GRT), leading to improved control over fluctuations in plasma drug concentration. To achieve this, FDDS must possess sufficient struc

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Lee, Sang-Ho, and Joo-Eun Kim. "Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet." Pharmaceutics 13, no. 2 (2021): 259. http://dx.doi.org/10.3390/pharmaceutics13020259.

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The aim of this study was to develop immediate-release oral rabeprazole sodium tablets with rapid efficacy and gastric stability for the treatment of gastroesophageal reflux disease. Rabeprazole sodium is a commonly prescribed proton pump inhibitor; however, it is extremely unstable and degrades in acidic environments. Hence, it has been manufactured and supplied only in enteric-coated tablet form, while immediate-release (IR) formulations for this drug are very limited. In this study, we applied the quality by design (QbD) approach to formulate and optimize an IR dry-coated tablet containing

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Lamkhade, Snehal* Shelke Pranali Dr. Wakale Vijaykumar S. "A Brief Review on Quinine Sulphate Sustained Release Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4558–64. https://doi.org/10.5281/zenodo.15527245.

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Malaria continues to pose a significant global health burden, particularly in developing regions with limited healthcare access. Conventional antimalarial therapies, while effective, suffer from limitations such as short drug half-lives, poor patient compliance, and the rising threat of drug resistance. In response to these challenges, sustained release (SR) tablet formulations are emerging as a promising strategy to optimize antimalarial drug delivery. This review paper presents a comprehensive overview of the formulation approaches, materials used, pharmacokinetic benefits, and clinical impl

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Shrikant, S. Dongare* Mr. Dnyaneshwar S. Vyavhare Dr. Megha T. Salve. "Concept And Recent Advancement In Tablet Coating Technologies: A Comprehensive Review." International Journal in Pharmaceutical Sciences 1, no. 11 (2023): 496–506. https://doi.org/10.5281/zenodo.10207162.

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Tablet coating, an enduring pharmaceutical process, involves the application of a dry outer layer to confer specific benefits on the dosage form, such as taste and odor masking, physical and chemical protection, protects the drug from the gastric surroundings, and control over release profiles. This technique, applicable to various solid oral forms, including particles, powders, granules, crystals, pellets, and tablets, employs a sugar or polymeric coat.  Traditional methods, like sugar coating, film coating, and enteric coating, were once prevalent, but recent advancements have circumven

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Kute, Vaibhav Ghansham, Rajeshwari Satish Patil, Vaishnavi Ghansham Kute, and Priti Dilip Kaluse. "Immediate-release dosage form; focus on disintegrants use as a promising excipient." Journal of Drug Delivery and Therapeutics 13, no. 9 (2023): 170–80. http://dx.doi.org/10.22270/jddt.v13i9.6217.

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Disintegrants are materials or mixtures of substances added in the drug formulations, which make easier dispersion or breakup of tablets and ingredients of capsules in small-scale particles for fast dissolution then it comes in contact with water in the GI tract. Immediate drug release dosage forms disintegrate rapidly after administration with an enhanced rate of dissolution. The superdisintegrants provide instantaneous disintegration of tablets after administration in the stomach. In this field, immediate-release liquid dosage forms and parenteral dosage forms have also been introduced for t

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9

Kotame, Radhika N., and Kratika Daniel. "Formulation, Development and Optimization of Silymarin Loaded Nanoparticle Orodispersible Tablets for its Anti-inflammatory Activity." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1722–27. http://dx.doi.org/10.25258/ijddt.14.3.67.

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The objective of this work was to enhance the anti-inflammatory properties of silymarin by developing and refining an orodispersible tablet formulation loaded with nanoparticles. Formulation development and optimization of silymarin-loaded nanoparticle orodispersible tablet for its anti-inflammatory activity is the focus of this research paper. Nanoparticle drug delivery systems can help to overcome these limitations by enhancing solubility and absorption. Disintegration and dissolution of Orodispersible tablets take place in the mouth rapidly without water, providing a faster onset of action.

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Patil, Vinod S., Benjamin C. Burdette, J. Zach Hilt, Douglass S. Kalika та Thomas D. Dziubla. "Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin". Gels 8, № 6 (2022): 337. http://dx.doi.org/10.3390/gels8060337.

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Oral drug delivery remains the most common and well tolerated method for drug administration. However, its applicability is often limited due to low drug solubility and stability. One approach to overcome the solubility and stability limitations is the use of amorphous polymeric prodrug formulations, such as poly(β-amino ester) (PBAE). PBAE hydrogels, which are biodegradable and pH responsive, have shown promising results for the controlled release of drugs by improving the stability and increasing the solubility of these drugs. In this work, we have evaluated the potential use of PBAE prodrug

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Sahu, Dr Gyanesh Kumar. "A Review on Role of Sustained Release Tablets in Improving Patient Compliance and Therapeutic Outcomes." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 12 (2024): 1–7. https://doi.org/10.55041/ijsrem39580.

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Sustained release tablets represent a significant advancement in pharmaceutical drug delivery, offering controlled and prolonged release of active ingredients to enhance therapeutic outcomes. This novel approach addresses the limitations of conventional dosage forms by maintaining consistent plasma drug levels, reducing dosing frequency, and improving patient compliance. Sustained release systems utilize various technologies, including matrix systems, reservoir systems, and osmotic pumps, to regulate drug release over an extended period. This review provides a comprehensive analysis of the des

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Ahmed, Mohd Salman, Nikita Upadhyay, and P. K. Dubey. "A REVIEW ON FAST DISSOLVING TABLET." International Journal of Pharmaceutical Sciences and Medicine 7, no. 5 (2022): 37–47. http://dx.doi.org/10.47760/ijpsm.2022.v07i05.004.

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Fast dissolving tablets (FDTs) emerged as one of the popular and widely accepted dosage forms. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia) resulting many incidences of non-compliance and making the therapy ineffective. Specifically for paediatric patients because of incomplete development of the muscular and nervous system and case of geriatric patients suffering from Parkinson’s disorder. Oral dosage form and oral route are the most preferred administration route for various drugs with limitations like first-p

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Pawar, Harshala, Aishwarya Pawar, and Shraddha N. Bhavsar. "FAST DISINTEGRATING TABLETS - A NEW ERA IN NOVEL DRUG DELIVERY SYSTEM." International Journal of Advanced Research 10, no. 01 (2022): 94–109. http://dx.doi.org/10.21474/ijar01/14018.

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Among all dosage forms, fast-Disintegrating tablets are one of the most commonly used dosage forms, especially in children, because their nervous system and muscular system are not well developed compared to them in adults. and in adult patients with Parkinsons disease or hand tremors. Some fixed dosage forms, such as capsules and tablets, now have difficulty swallowing (dysphagia), which results in many cases of non-compliance and renders therapy ineffective. The most preferred routes of administration for various drugs are oral dosage forms and the oral route with specific limitations such a

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Nishigandha, Pandurang Gite1* Vinayak Munde2. "Formulation And Evaluation Of Mucoadhesive Buccal Tablet Of Favipiravir." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3733–54. https://doi.org/10.5281/zenodo.13371490.

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This research work investigates the formulation and evaluation of mucoadhesive buccal tablets containing Favipiravir, an antiviral medication with proven efficacy against various RNA viruses, including influenza and certain strains of coronaviruses. The objective of this study is to develop a novel drug delivery system that enhances the bioavailability and therapeutic efficacy of Favipiravir through buccal administration, thereby addressing the limitations associated with conventional oral dosage forms. The formulation development phase involves the selection of suitable mucoadhesive polymers

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Pund, Atul, Atishkumar Mundada, Manoj Magar, and Abhijeet Kadam. "Recent Patents on Modified Release Oral Dosage Forms." Journal of Drug Delivery and Therapeutics 11, no. 4-S (2021): 195–211. http://dx.doi.org/10.22270/jddt.v11i4-s.4973.

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Background: Conventional oral dosage forms have limited bioavailability and frequent dosing of the drug is needed to maintain the effective therapeutic concentration in the body. This results in poor patient compliance and fluctuations in the plasma drug levels, especially in the chronic diseases and disorders. Objective: To overcome such problems and to enhance the efficiency and bioavailability of the drug, modified drug delivery systems such as extended release delivery systems (controlled release; sustained release) and delayed release delivery systems are developed which can prolong

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Chandani, Rajak* Meenakshi Kandwal Shivanand Patil. "Non-Effervescent Gastro-Retentive Tablets For Controlled Release Of Pregabalin." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 732–42. https://doi.org/10.5281/zenodo.13764897.

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The development and assessment of non-effervescent tablets are essential for ensuring the controlled release of active ingredients such as Pregabalin. Non-effervescent tablets are specifically designed to release medication gradually and consistently over an extended period, which is particularly advantageous for drugs like Pregabalin utilizing HPMC K100M and Carbopol 971P as release-retarding polymers. The objective of this study was to create and assess controlled release matrix tablets containing Pregabalin. The main purpose of this study was to develop gastroretentive tablets with floating

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17

Mohammed, B. B., T. J. Hayab, and Z. S. Yahaya. "Evaluation of the sustained release potential of a co-processed excipient in Ibuprofen tablet formulation." Journal of Basic and Social Pharmacy Research 1, no. 4 (2020): 13–23. http://dx.doi.org/10.52968/27453177.

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Background: The oral route happens to be the most preferred route among the various routes of drug delivery. However, the conventional dosage form has few limitations which could be resolved by modifying the existing dosage form. Sustained and controlled drug delivery systems help to maintain constant plasma drug concentration and retarding the release rate of drug thereby extending the duration of action. Objectives: To develop by co-processing technique a two-component excipient and evaluate its sustained release potential in ibuprofen tablet formulation. Method: Maize starch (MS) was co-pro

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Tejal, T. Patil* S. S. Shelake N. B. Chougle. "A Brief Review on Tablet Coating." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 850–62. https://doi.org/10.5281/zenodo.10854709.

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A tablet or granule for API is coated using pharmaceutical technology with a thin polymer-based film. It has the benefit of disguising the drug's taste, odor, and color.It generates physical, chemical, and gastrointestinal environment protection for the medication In pharmaceutical dosage forms, coating is an important element that affects bioavailability, shelf life, and drug release. Different coating methods are applied to solid dosage forms to enhance their performance, such as enteric coating, film coating, and sugar coating. Getting over the limitations of solvent-based coating is the ke

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Afreen, Nagori* Akanksha Jagwani Vikas Jain. "A Review Of Fast Dissolving Tablet." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 601–9. https://doi.org/10.5281/zenodo.11186249.

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The fast-dissolving tablet (FDT) is an innovative and unique drug delivery system that is rapidly gaining attention in fast-dissolving technology research. Fast dissolving tablets are proving to be one of the most popular and widely accepted dosage forms, especially in pediatric patients due to incomplete development of muscles and nervous system and in geriatric patients suffering from Parkinson's disease or hand tremors. The oral dosage form and route is the most preferred route of administration for various drugs that have limitations such as e.g. First-pass metabolism, psychiatric patients

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Masih, Ashish, Amar Kumar, Shivam Singh, and Ajay Kumar Tiwari. "FAST DISSOLVING TABLETS: A REVIEW." International Journal of Current Pharmaceutical Research 9, no. 2 (2017): 8. http://dx.doi.org/10.22159/ijcpr.2017v9i2.17382.

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Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitation

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Vlachou, Marilena, Georgios-Marios Bolbasis, Anna-Evaggelia Trikali, et al. "Release Behavior of the Pineal Hormone Melatonin from Modified Matrix Tablets Based on Poly(L-Lactic Acid) and Its Derivatives." Applied Sciences 15, no. 4 (2025): 2054. https://doi.org/10.3390/app15042054.

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Biodegradable polyesters have been researched intensively over the last two decades because of their biodegradability and superb physical properties. However, the use of linear biodegradable polyesters, for the preparation of drug delivery systems (DDS), is hampered by several limitations. In view of this, scientific attention has been shifted to the employment of branched-chain (co-)polymers. In this context, we present herein the development of new melatonin (MLT) tablet formulations, using novel branched polylactide (PLA)-based copolymers of different architectures. Specifically, three PLA-

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Shivaji, Patil* Samrudh Shinde Pritam Salokhe Nilesh Chougule. "Formulation & Evaluation Of Mucoadhesive Tablet Of Ranolazine." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1627–35. https://doi.org/10.5281/zenodo.12795739.

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Ranolazine is an anti-anginal drug with extensive and highly variable hepatic first pass metabolism following oral administration, with systemic bio-availability of 76% and ranolazine also has a relatively short plasma half-life of 2.5+0.5 hours. Ranolazine, a promising therapeutic agent for the management of chronic angina, poses challenges in its conventional tablet formulation due to its low bioavailability and short half-life. To address these limitations, novel drug delivery systems (NDDS) offer innovative approaches to enhance drug efficacy and patient compliance. This research paper exp

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Lenz, Jan, Frederik Fuest, Jan Henrik Finke, Heike Bunjes, Arno Kwade, and Michael Juhnke. "Tablet Disintegration and Dispersion under In Vivo-like Hydrodynamic Conditions." Pharmaceutics 14, no. 1 (2022): 208. http://dx.doi.org/10.3390/pharmaceutics14010208.

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Disintegration and dispersion are functional properties of tablets relevant for the desired API release. The standard disintegration test (SDT) described in different pharmacopoeias provides only limited information on these complex processes. It is considered not to be comparable to the biorelevant conditions due to the frequent occurrence of high hydrodynamic forces, among other reasons. In this study, 3D tomographic laser-induced fluorescence imaging (3D Tomo-LIF) is applied to analyse tablet disintegration and dispersion. Disintegration time (DT) and time-resolved particle size distributio

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Rushikesh Mahale, Rushikesh Mahale, Dr Shivraj Jadhav Dr. Shivraj Jadhav, and Dr Sunil Mahajan Dr. Sunil Mahajan. "Gastro- Retentive floating tablets: A promising strategy for improving dapsone therapeutic efficacy." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 254–70. https://doi.org/10.35629/4494-1003254270.

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This review explores the formulation and development of floating tablets for gastro-retentive drug delivery systems (GRDDS), focusing on their ability to prolong gastric retention and enhance the therapeutic efficacy of drugs with narrow absorption windows. The article discusses key components of floating tablet systems, mechanisms of buoyancy, materials, methods, and evaluation parameters. The significance of such systems for improving therapeutic outcomes and patient compliance is highlighted, along with the limitations and challenges faced in formulation.Dapsone is a widely used antimicrobi

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Hida, Yuki, Teruhiko Imamura, and Koichiro Kinugawa. "Impact of Conversion from Conventional Pemafibrate to Novel Pemafibrate XR on Hypertriglyceridemia: An Observational Retrospective Study." Journal of Clinical Medicine 13, no. 19 (2024): 5879. http://dx.doi.org/10.3390/jcm13195879.

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Background: Pemafibrate is a novel selective peroxisome proliferator-activated receptor-α modulator, which was demonstrated to reduce serum triglyceride levels with few drug-related adverse events in several clinical studies, as well as phase II and III clinical trials. One of the limitations of this medicine was the requirement of twice-daily oral administration, resulting in reduced medication adherence, particularly in elderly patients, who are rather good targets for this medicine. Recently, a once-daily extended-release (XR) tablet has been introduced. Given an improvement in medication a

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Senthil, S. P. "FORMULATION AND INVITRO EVALUATION OF MOUTH MELTING TABLETS OF TELMISARTAN USING NATURAL SUPERDISINTEGRANT." YMER Digital 21, no. 03 (2022): 300–312. http://dx.doi.org/10.37896/ymer21.03/33.

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This tablet is formulated by direct compression method by using natural superdisintegrant such as Hibiscus and Fenugreek for the benefits of agents which make the drug disintegrate rapidly in water by wicking or swelling or by any other mechanisms This type of property in dosage form can be attained by addition of different excipients, from which disintegrant is the key adjuvant. In recent years, several newer agents have been developed known as superdisintegrants. Diverse categories of superdisintegrants such as synthetic, semisynthetic, natural and co-processed blends etc. have been employed

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Vishakha, Vishwanath Doke, M. Khutle Nilesh, Sharma Maya, and Gupta Khemchand. "Solubility Enhancement of Poorly Soluble Drug Ezetimibe by Developing Self Nano Emulsifying Drug Delivery System." Indian Journal of Science and Technology 15, no. 30 (2022): 1504–16. https://doi.org/10.17485/IJST/v15i30.582.

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Abstract <strong>Objectives:</strong> To enhance solubility, dissolution, and permeability of poorly water-soluble drug Ezetimibe (EZE) using a self-nano emulsifying drug delivery system (SNEDDS). <strong>Methods:</strong> Initially, the solubility of the EZE was determined in various oils and buffers. Surfactants and co-surfactants were screened based on the solubility of the drug in oil as per the emulsification efficacy test. Liquid SNEDDS was developed and characterized. Solid SNEDDS was developed and characterized using optimized liquid SNEDDS followed by the development of

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Alqahtani, Abdulsalam A., Abdul Aleem Mohammed, Farhat Fatima, and Mohammed Muqtader Ahmed. "Fused Deposition Modelling 3D-Printed Gastro-Retentive Floating Device for Propranolol Hcl Tablets." Polymers 15, no. 17 (2023): 3554. http://dx.doi.org/10.3390/polym15173554.

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Three-dimensional printing has revolutionized drug manufacturing and has provided a solution to the limitations associated with the conventional manufacturing method by designing complex drug delivery systems with customized drug release profiles for personalized therapies. The present investigation aims to design a gastric floating tablet with prolonged gastric floating time and sustained drug release profile. In the present study, a gastro retentive floating device (GRFD) was designed and fabricated using a fused deposition modelling (FDM)-based 3D printing technique. This device acts as a m

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Schoedel, Kerri A. "Reduced Cognitive and Psychomotor Impairment with Extended-Release Oxymorphone Versus Controlled-Release Oxycodone." Pain Physician 6;13, no. 6;12 (2010): 561–73. http://dx.doi.org/10.36076/ppj.2010/13/561.

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Background: Opioids provide effective pain control, yet have risks including adverse events (AEs) (e.g., constipation, nausea/vomiting, sedation) and cognitive/psychomotor effects. Objective: To compare cognitive and psychomotor effects of oxymorphone extended release (OM-ER) versus oxycodone controlled release (OC-CR). Study design: Randomized, double-blind, 5-way crossover Setting: Single inpatient research unit Methods: Nondependent recreational opioid users were administered single intact oral tablets of placebo, OM-ER (15 and 30 mg), and OC-CR (30 and 60 mg), separated by a 7- to 21-day w

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Nilesh, Mhaske Sudarshan Rashinkar. "Formulation And Evaluation Of Sustained Release Tablet Of Captoprilusing Cross-Linked Alginate." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 2054–64. https://doi.org/10.5281/zenodo.13117591.

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Over the past three decades, formulation technology has significantly advanced, particularly in drug delivery systems. Innovations include novel dosage forms and new uses for existing drugs, offering benefits like improved patient compliance, sustained drug concentration, reduced dosing frequency, targeted delivery, and minimized side effects. Transdermal drug delivery systems (TDDS) are key developments, allowing controlled, continuous medication administration through the skin, bypassing gastrointestinal degradation and hepatic first-pass metabolism, and enhancing bioavailability and patient

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Bílik, Tomáš, Jakub Vysloužil, Martina Naiserová, et al. "Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study." Pharmaceutics 14, no. 1 (2022): 127. http://dx.doi.org/10.3390/pharmaceutics14010127.

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Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in various pharmaceutical fields of interest. We aimed to explore its application in hypromellose matrix systems (HPMC content 10–30%) compared to the traditionally used microcrystalline cellulose (MCC) PH 102. The properties of powder mixtures and directly compressed tablets containing individual fillers NEU or MCC, or their blend with ratios of 1.

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Vitthal, S. Shinde* Vijay M. Kanade Ajit B. Tuwar Megha T. Salve. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE ANASTROZOLE TABLET FOR TREATMENT OF BREAST CANCER." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 1084–90. https://doi.org/10.5281/zenodo.11234851.

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Breast cancer is the major global health concern and second most common cancer in women. While breast cancer can also occur in men, but it is much less common. Early detection and treatment are important for improving the outcome of breast cancer. The past decade has gain significant advancements in both understanding breast cancer and developing preventative methods. The most common preventive method is the chemotherapy which including various types of medication. Anastrozole is a nonsteroidal drug and act as selective aromatase inhibitor, which plays a crucial role in endocrine therapy for c

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Roman, Vaishnavi* Gaikwad Rutuja. "Development And Characterization of Lornoxicam Tablets Incorporating Banana Starch as A Superdisintegrating for Enhanced Dissolution." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2058–63. https://doi.org/10.5281/zenodo.15232534.

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Orally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, in which disintegrants are the key adjuvant. In recent years, several newer agents have been developed known as super-disintegrants. Super-disintegrants are used to improve the efficacy of solid dosage form and influence the release rate

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Farhaj, Samia, Barbara R. Conway, and Muhammad Usman Ghori. "Nanofibres in Drug Delivery Applications." Fibers 11, no. 2 (2023): 21. http://dx.doi.org/10.3390/fib11020021.

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Over the years, scientists have been continually striving to develop innovative solutions to design and fabricate medicines with improved therapeutic potential. Conventional dosage forms, such as tablets, capsules, and injections, are limited when exploited for advanced therapeutics, such as drug targeting. To cater to these limitations, nanofibres have emerged as novel nanomaterials to provide enhanced bioavailability, targeted drug release, extended drug release profile, minimum toxicity, and reduced dosage frequency, which has indisputably improved patient adherence and compliance. This rev

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Zimina, L. V. "Interactive eBook Applications in the Context of the Modern Media System: Release and Promotion Strategies." Bibliosphere, no. 4 (November 8, 2021): 29–38. http://dx.doi.org/10.20913/1815-3186-2021-4-29-38.

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The article treats digital technologies impact on modern ways of content producing, promotion and consumption. The focus is on interactive book apps as innovative publishing projects that use interactive multimedia content. Interactive book apps are designed for tablets and smartphones and combine different elements (texts, images, video, audio, animation and so on). The author traces back in short e-books prehistory from Kindle gadgets to the time of innovative iPad tablet that resulted in a new generation of e-books. Different types of interactive book apps are highlighted in the article on

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Pandav, Tisha, Tejal Devare, Pankaj Pant, Tejal Devare, and Ashwin Mali. "Dr DEVELOPMENT OF POSACONAZOLE DELAYED RELEASE FORMULATION FOR MUCORMYCOSIS BY HOT MELT EXTRUSION USING QBD APPROACH." Journal of Advanced Scientific Research 14, no. 08 (2023): 28–39. http://dx.doi.org/10.55218/jasr.202314805.

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Amorphous solid dispersion (ASD) by hot-melt extrusion (HME) is an industrially feasible approach to overcome the solubility and bioavailability limitations of poorly soluble active pharmaceutical actives. The creation of HME-based ASDs was significantly impacted by the implementation of Quality by Design (QbD). The objective of the study was to develop an ASD of posaconazole for the effective management of mucormycosis. The impact of change in levels of extra granular materials were identified as critical quality attributes (CQA's) for the development of delayed release tablet. A 23 full fact

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Disha, Wankhede* Damini Mundhare. "Formulation And Evaluation Of Oral Dispersible Tablet Containing Giloy." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 342–50. https://doi.org/10.5281/zenodo.14045993.

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Tablets, the most common drug delivery system, provide the opportunity to incorporate new technologies to produce more dosage forms. Orally dispersible drug delivery systems are widely used to improve bioavailability and patient compliance. Orally dispersible tablets (ODT) have been developed for children, the elderly, bedridden patients, and patients without access to water. In fact, swallowing problems develop in young people due to weakening of muscles and nerves. In some cases, such as cold, cough and inability to drink, tablets may be difficult or uncomfortable to swallow. ODT creates a s

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Christina Viju John, Nisarga Arun Vavre, Shilpa Sampat Sawant, Abhishek Lalan Sharma, Kajal Shankar Shah, and Shrutika Dipesh Patil. "Oral mucoadhesive drug delivery system: Formulation strategies and evaluation techniques." World Journal of Advanced Research and Reviews 24, no. 1 (2024): 1706–19. http://dx.doi.org/10.30574/wjarr.2024.24.1.3199.

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Mucoadhesive drug delivery systems (MDDS) represent an innovative method for administering drugs through oral routes such as the buccal, sublingual, and gingival areas. These systems leverage natural or synthetic polymers to ensure prolonged adherence to mucosal surfaces, enabling extended and controlled release of medication. Several factors influence the effectiveness of mucoadhesion, including the hydrophilicity of polymers, molecular weight, and environmental factors like pH and moisture levels. MDDS can take various forms, including tablets, films, patches, lozenges, and gels, each offeri

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Christina, Viju John, Arun Vavre Nisarga, Sampat Sawant Shilpa, Lalan Sharma Abhishek, Shankar Shah Kajal, and Dipesh Patil Shrutika. "Oral mucoadhesive drug delivery system: Formulation strategies and evaluation techniques." World Journal of Advanced Research and Reviews 24, no. 1 (2024): 1706–19. https://doi.org/10.5281/zenodo.15039388.

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Mucoadhesive drug delivery systems (MDDS) represent an innovative method for administering drugs through oral routes such as the buccal, sublingual, and gingival areas. These systems leverage natural or synthetic polymers to ensure prolonged adherence to mucosal surfaces, enabling extended and controlled release of medication. Several factors influence the effectiveness of mucoadhesion, including the hydrophilicity of polymers, molecular weight, and environmental factors like pH and moisture levels. MDDS can take various forms, including tablets, films, patches, lozenges, and gels, each offeri

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Abhijeet, Welankiwar* Gunjan Sahu Pradyumna Keche. "Exploring Process Analytical Technology: Applications and Benefits in Pharma Operations A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 238–48. https://doi.org/10.5281/zenodo.14972354.

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The integration of advanced analytical technologies, specifically Continuous Process Verification (CPV), Quality by Design (QbD), and Process Analytical Technology (PAT), within pharmaceutical manufacturing. Traditional Quality Control (QC) methods, which primarily rely on post-manufacturing checks, are limited in addressing real-time variability in the process. To overcome these limitations, CPV enables continuous monitoring and a better understanding of process variations. QbD fosters a systematic approach to correlate critical process parameters (CPPs) with critical quality attributes (CQAs

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Kreft, Klemen, Marina Fanous, and Volker Möckel. "The potential of three-dimensional printing for pediatric oral solid dosage forms." Acta Pharmaceutica 74, no. 2 (2024): 229–48. http://dx.doi.org/10.2478/acph-2024-0012.

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Abstract Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid formulations, have limitations in terms of dosing accuracy and palatability. This paper explores the potential of 3D printing as a solution to address the challenges and provide tailored doses of medication for each pediatric patient. The technological overview of 3D printing is discussed, highlighting various 3D printing technologies and

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Zeng, Hui-lin, Qian Qiu, Ting-xiong Fu, Ai-ping Deng, and Xiang-yang Xie. "Development and optimization of sustained release triptolide microspheres." PLOS ONE 18, no. 10 (2023): e0292861. http://dx.doi.org/10.1371/journal.pone.0292861.

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Rheumatoid arthritis is considered a chronic systemic autoimmune disorder that may cause joint destruction. Triptolide, an active component isolated from Tripterygium wilfordii Hook.f., is considered to have promising potential for clinical use in treating rheumatoid arthritis. However, its clinical application has been limited by the narrow therapeutic window, side effects associated with plasma drug fluctuations, low oral bioavailability, and poor patient compliance with the long and frequent dosing regimen. An extended drug release preparation may address these limitations. The aim of this

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Trivedi, Dipali, Arti Majumdar, and Neelesh Malviya. "Development and Evaluation of Gastro-retentive Floating Tablet of Rilpivirine Hydrochloride for the Treatment of HIV." Journal of Drug Delivery and Therapeutics 10, no. 3-s (2020): 43–46. http://dx.doi.org/10.22270/jddt.v10i3-s.4115.

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Besides enormous improvements in drug delivery, oral route has been highly and effectively utilized route of administration. Floating drug delivery that is also known to be low density system is advancement in the class of gastro-retentive drug delivery system. In the present research work, floating drug delivery of Rilpivirine hydrochloride was developed by overcoming various limitations and troubles associated with the drug including poor absorption in intestinal pH and degradation when comes in contact with higher pH environment. [2] Prepared formulations were evaluated for various paramete

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Darkes, Malcolm J. M., and Caroline M. Perry. "Clarithromycin Extended-Release Tablet." American Journal of Respiratory Medicine 2, no. 2 (2003): 175–201. http://dx.doi.org/10.1007/bf03256648.

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Guembe-Michel, Nerea, Paul Nguewa, and Gustavo González-Gaitano. "Soluplus®-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications." International Journal of Molecular Sciences 26, no. 4 (2025): 1499. https://doi.org/10.3390/ijms26041499.

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Poor water solubility remains a significant challenge in the pharmaceutical industry that limits the therapeutic efficacy and bioavailability of many active pharmaceuticals. Soluplus® (SLP), an amphiphilic graft copolymer made of polyethylene glycol, polyvinyl caprolactam, and polyvinyl acetate, has been gaining interest in recent years as it addresses these limitations by acting as a versatile carrier. Its ability to form stable amorphous dispersions and enhance drug solubility, as well as its physicochemical properties, support its role as a key excipient in advanced drug delivery systems. R

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Khodade, Rajendra Kisanrao, and Kore Kakasaheb Jagannath. "Quality By Design (Qbd) Based Manufacturing Process Optimization For Robust Manufacturing Of Ibuprofen Tablets." Journal of Neonatal Surgery 14, no. 24S (2025): 382–413. https://doi.org/10.63682/jns.v14i24s.5968.

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The pharmaceutical industry continues to face challenges in the seamless manufacturing of ibuprofen tablets, despite decades of commercial production. Key issues include the drug’s inherent properties—such as its low melting point (70°C), which causes sticking during compression—as well as solubility and in vitro release challenges due to its BCS Class II classification. Additionally, modifying API properties and approved formulations involves significant regulatory and cost constraints under SUPAC Level 2 changes. While Quality by Design (QbD) approaches have primarily focused on Critical Mat

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Rauck, MD, Richard L., Stephen A. Bookbinder, MD, Timothy R. Bunker, MD, et al. "A randomized, open-label, multicenter trial comparing once-a-day AVINZA® (morphine sulfate extended-release capsules) versus twice-a-day OxyContin® (oxycodone hydrochloride controlled-release tablets) for the treatment of chronic, moderate to severe low back pain: Improved physical functioning in the ACTION trial." Journal of Opioid Management 3, no. 1 (2007): 35. http://dx.doi.org/10.5055/jom.2007.0037.

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This multicenter trial compared the efficacy, safety, and effect on quality of life and work limitation of once-daily extended-release morphine sulfate capsules (AVINZA9, A-MQD) and twice-daily controlled-release oxycodone HCl tablets (OxyContin9, O-ER) in subjects with chronic, moderate to severe low back pain. After randomization and a period of opioid dose titration, subjects (n = 266) underwent an eight-week evaluation phase and an optional four-month extension phase (n = 174 in extension phase). Subjects were assessed using the 12-item Short-Form Health Survey9 (SF-12) and the Work Limita

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Saha, Shreya, Mithun Bhowmick, and Rimpa Goswami. "Bilayer Tablet: Novel Technology Use in Extended Release Drug Delivery System." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 962–65. http://dx.doi.org/10.22270/jddt.v9i3-s.2877.

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Bilayer tablet is a successful technology of controlled release formulation or extended release formulation to provide successful drug delivery. The name of this development is clear that the tablets have been consisting of two layers, these are immediate release layer (IR) and another is extended release layer (ER). In this era it is very useful in many developing countries as a combination therapy for various disease treatment purposes. Bilayer tablet are needs to separate incompatible active pharmaceutical ingredients (API) by physical separation. In this formulation IR and ER both layers a

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Menon, R., D. Tolbert, and E. Cefali. "The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet." Biopharmaceutics & Drug Disposition 28, no. 6 (2007): 297–306. http://dx.doi.org/10.1002/bdd.555.

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MAHAJAN, NILESH M., Kalyanee Wanaskar, Yogesh Bhutada, Raju Thenge, and Vaibhav Adhao. "DESIGN AND IN VITRO EVALUATION OF EXTENDED RELEASE TABLET OF NATEGLINIDE." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 235–39. http://dx.doi.org/10.22270/jddt.v8i5-s.2012.

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The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15, it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were st

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