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Journal articles on the topic 'Limiting cycle'

Author: Grafiati
Published: 28 May 2022
Last updated: 30 July 2025

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1

Fisher, A. J. "Loran-C cycle identification in hard-limiting receivers." IEEE Transactions on Aerospace and Electronic Systems 36, no. 1 (2000): 290–97. http://dx.doi.org/10.1109/7.826332.

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2

Vasseur, E., P. Navidi, and S. Hariri. "Direct determination of limiting cycle during cyclic loading." Computational Materials Science 7, no. 1-2 (1996): 11–15. http://dx.doi.org/10.1016/s0927-0256(96)00053-5.

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3

Molokov, K. A., Valery V. Novikov, Ya R. Domashevskaya, and A. I. Mamontov. "Engineering Method for Calculating the Limiting Amplitudes of Stress Cycles for Structural Steels." Materials Science Forum 1084 (April 13, 2023): 117–22. http://dx.doi.org/10.4028/p-rm063t.

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In large-sized metal structures, various stress concentrators are often present, which affects the operation of the material. These are intermittent bonds, holes, welded joints, material defects, etc. As a result of overloads under the action of an external cyclic load on structures in the area of stress raisers, the cycle asymmetry, the level of maximum stresses and deformations increase. In this case, the determination of the limit values of the stress cycles can be performed using a diagram of the limit stress amplitudes. The paper presents an engineering method for calculating the limiting
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4

Fu, Jiawei, Zhenhua Liu, Xingyang Yang, Sumin Jin, and Jilei Ye. "Limiting Performance of the Ejector Refrigeration Cycle with Pure Working Fluids." Entropy 25, no. 2 (2023): 223. http://dx.doi.org/10.3390/e25020223.

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An ejector refrigeration system is a promising heat-driven refrigeration technology for energy consumption. The ideal cycle of an ejector refrigeration cycle (ERC) is a compound cycle with an inverse Carnot cycle driven by a Carnot cycle. The coefficient of performance (COP) of this ideal cycle represents the theoretical upper bound of ERC, and it does not contain any information about the properties of working fluids, which is a key cause of the large energy efficiency gap between the actual cycle and the ideal cycle. In this paper, the limiting COP and thermodynamics perfection of subcritica
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5

Degtyarev, V. A. "Prediction of limiting amplitudes of cycle stresses of welded joints with steady residual stresses." Paton Welding Journal 2016, no. 10 (2016): 14–19. http://dx.doi.org/10.15407/tpwj2016.10.03.

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6

Klik, Ivo, and Ching-Ray Chang. "Approach to a Limiting Cycle in Thermally Relaxing Media." SPIN 05, no. 01 (2015): 1550001. http://dx.doi.org/10.1142/s2010324715500010.

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The thermally activated dynamics of an uniaxial superparamagnetic particle are studied here from the point of view of approach towards a steady state minor hysteresis loop representing a limiting cycle. The particle is initially at an arbitrary state, and is driven by a sufficiently small external applied ac magnetic field till the limiting minor hysteresis loop is reached with a desired precision. The number of periods required to reach the limiting cycle is found to satisfy an Arrhenius-type law, with an exponential dependence on the inverse ambient temperature. We tentatively associate this
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7

Tsou, Meng-Fu Bryan, and Tim Stearns. "Mechanism limiting centrosome duplication to once per cell cycle." Nature 442, no. 7105 (2006): 947–51. http://dx.doi.org/10.1038/nature04985.

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8

Jordinson, C., and D. O. Gough. "The Effect of the Solar Cycle on the Resonant Coupling of g Modes." International Astronomical Union Colloquium 176 (2000): 390. http://dx.doi.org/10.1017/s0252921100058164.

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AbstractWe consider the effect of the solar cycle on g-mode parametric resonance, and hence on the limiting amplitude of the overstable solar g1(ℓ = 1) mode. We find no change in the expected limiting amplitude from that found by Dziembowski (1983), who ignored cycle variations.
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9

Kim, Jin-Seok, Sung-Hun Lim, and Jae-Chul Kim. "Comparative Analysis on Current Limiting Characteristics of Hybrid Superconducting Fault Current Limiters (SFCLs) with First Half Cycle Limiting and Non-Limiting Operations." Journal of Electrical Engineering and Technology 7, no. 5 (2012): 659–63. http://dx.doi.org/10.5370/jeet.2012.7.5.659.

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10

Lehnert, Nicolai, Bradley W. Musselman, and Lance C. Seefeldt. "Grand challenges in the nitrogen cycle." Chemical Society Reviews 50, no. 6 (2021): 3640–46. http://dx.doi.org/10.1039/d0cs00923g.

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In this Viewpoint, we address limitations within our current understanding of the complex chemistry of the enzymes in the Nitrogen Cycle. Understanding of these chemical processes plays a key role in limiting anthropogenic effects on our environment.
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11

Birchfield, Edward, and Matthew Wyant. "Diverse Limiting Circulations In A Simple Ocean Box Model." Annals of Glaciology 14 (1990): 330. http://dx.doi.org/10.3189/s0260305500008892.

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A coupled ocean-atmosphere model is formulated, incorporating an ocean comprised of two surface and one deep-ocean boxes, horizontal and vertical mixing, a thermohaline circulation, and forcing by latitudinal differential surface heating and evaporation. Surface fluxes are determined through coupling with a two-box steady-state atmospheric energy-balance model The hydrological cycle, thermohaline circulation and latitudinal exchange rate in the atmosphere are each controlled by an independent parameter. For a weak hydrological cycle, a cold low-salinity deep-ocean equilibrium exists with deep
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12

Birchfield, Edward, and Matthew Wyant. "Diverse Limiting Circulations In A Simple Ocean Box Model." Annals of Glaciology 14 (1990): 330. http://dx.doi.org/10.1017/s0260305500008892.

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A coupled ocean-atmosphere model is formulated, incorporating an ocean comprised of two surface and one deep-ocean boxes, horizontal and vertical mixing, a thermohaline circulation, and forcing by latitudinal differential surface heating and evaporation. Surface fluxes are determined through coupling with a two-box steady-state atmospheric energy-balance model The hydrological cycle, thermohaline circulation and latitudinal exchange rate in the atmosphere are each controlled by an independent parameter. For a weak hydrological cycle, a cold low-salinity deep-ocean equilibrium exists with deep
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13

Finkelstein, Maxim. "On Some Ageing Properties of General Repair Processes." Journal of Applied Probability 44, no. 2 (2007): 506–13. http://dx.doi.org/10.1239/jap/1183667417.

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We consider ageing properties of a general repair process. Under certain assumptions we prove that the expectation of an age at the beginning of the next cycle in this process is smaller than the initial age of the previous cycle. Using this reasoning, we show that the sequence of random ages at the start (end) of consecutive cycles is stochastically increasing and is converging to a limiting distribution. We discuss possible applications and interpretations of our results.
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14

Finkelstein, Maxim. "On Some Ageing Properties of General Repair Processes." Journal of Applied Probability 44, no. 02 (2007): 506–13. http://dx.doi.org/10.1017/s002190020011798x.

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We consider ageing properties of a general repair process. Under certain assumptions we prove that the expectation of an age at the beginning of the next cycle in this process is smaller than the initial age of the previous cycle. Using this reasoning, we show that the sequence of random ages at the start (end) of consecutive cycles is stochastically increasing and is converging to a limiting distribution. We discuss possible applications and interpretations of our results.
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15

Finkelstein, Maxim. "On Some Ageing Properties of General Repair Processes." Journal of Applied Probability 44, no. 02 (2007): 506–13. http://dx.doi.org/10.1017/s0021900200003120.

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We consider ageing properties of a general repair process. Under certain assumptions we prove that the expectation of an age at the beginning of the next cycle in this process is smaller than the initial age of the previous cycle. Using this reasoning, we show that the sequence of random ages at the start (end) of consecutive cycles is stochastically increasing and is converging to a limiting distribution. We discuss possible applications and interpretations of our results.
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16

Makhnenko, O. V., O. S. Milenin, O. A. Velykoivanenko, G. P. Rozynka, and N. I. Pivtorak. "Numerical analysis of the features of limiting state of welded pipeline elements under ultra-low-cycle loading conditions." Paton Welding Journal 2021, no. 1 (2021): 29–34. http://dx.doi.org/10.37434/tpwj2021.01.06.

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17

Daduna, Hans, Christian Malchin, and Ryszard Szekli. "Weak Convergence Limits for Sojourn Times in Cyclic Queues Under Heavy Traffic Conditions." Journal of Applied Probability 45, no. 2 (2008): 333–46. http://dx.doi.org/10.1239/jap/1214950351.

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We consider sequences of closed cycles of exponential single-server nodes with a single bottleneck. We study the cycle time and the successive sojourn times of a customer when the population sizes go to infinity. Starting from old results on the mean cycle times under heavy traffic conditions, we prove a central limit theorem for the cycle time distribution. This result is then utilised to prove a weak convergence characteristic of the vector of a customer's successive sojourn times during a cycle for a sequence of networks with population sizes going to infinity. The limiting picture is a com
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18

Daduna, Hans, Christian Malchin, and Ryszard Szekli. "Weak Convergence Limits for Sojourn Times in Cyclic Queues Under Heavy Traffic Conditions." Journal of Applied Probability 45, no. 02 (2008): 333–46. http://dx.doi.org/10.1017/s0021900200004265.

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We consider sequences of closed cycles of exponential single-server nodes with a single bottleneck. We study the cycle time and the successive sojourn times of a customer when the population sizes go to infinity. Starting from old results on the mean cycle times under heavy traffic conditions, we prove a central limit theorem for the cycle time distribution. This result is then utilised to prove a weak convergence characteristic of the vector of a customer's successive sojourn times during a cycle for a sequence of networks with population sizes going to infinity. The limiting picture is a com
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19

Mauer, A. M., G. A. Masters, D. J. Haraf, et al. "Phase I study of docetaxel with concomitant thoracic radiation therapy." Journal of Clinical Oncology 16, no. 1 (1998): 159–64. http://dx.doi.org/10.1200/jco.1998.16.1.159.

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PURPOSE The taxanes have demonstrated activity as radiation sensitizers in preclinical studies. This study was designed to determine the maximum-tolerated dose (MTD), optimal schedule, and toxicities of docetaxel in combination with concomitant standard chest radiotherapy. PATIENTS AND METHODS Twenty-nine patients with advanced non-small-cell lung or esophageal cancer enrolled in this phase I study to evaluate escalating docetaxel doses at three schedules. Docetaxel was administered as two 21-day cycles at doses of 40, 60, and 75 mg/m2 per cycle. Docetaxel administration schedules were as foll
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20

Hamraoui, Lamiae, Tinghui Zhang, Angela Crespi, et al. "Atomic layer etching of gallium nitride using fluorine-based chemistry." Journal of Vacuum Science & Technology A 41, no. 3 (2023): 032602. http://dx.doi.org/10.1116/6.0002452.

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Atomic layer etching (ALE) of GaN on silicon substrates has been investigated using fluorine-based chemistry. The ALE process used for this study consists of a modification step using SF6 plasma and a removal step using argon plasma. Two configurations were studied in which the distance between the sample and the plasma source was modified. The energy scan, synergy, selective etching of GaFx by Ar+ ion bombardment, and self-limiting etching regime of the ALE of GaN were first investigated. An etch per cycle of 0.50 nm/cycle averaged over 100 cycles was reached for GaN ALE. The self-limiting re
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21

Michael, Michael, MaryAnne Brittain, Jane Nagai, et al. "Phase II Study of Activated Charcoal to Prevent Irinotecan-Induced Diarrhea." Journal of Clinical Oncology 22, no. 21 (2004): 4410–17. http://dx.doi.org/10.1200/jco.2004.11.125.

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PurposeThe dose-limiting toxicity of irinotecan (CPT-11; Camptosar) is delayed-onset diarrhea, with an incidence at the grade 3 to 4 level of 20% to 35%. SN38, its active moiety, is responsible by a direct effect on mucosal topoisomerase-I. The aim of this study was to assess whether activated charcoal (AC), possibly by adsorbing free lumenal SN38, can reduce irinotecan-induced diarrhea (CID) and optimize its dose-intensity.Patients and MethodsPatients with advanced colorectal cancer receiving irinotecan 125 mg/m2intravenously once a week for 4 weeks every 6 weeks were studied. In cycle 1, pat
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22

Gao, Xun, Li Zhang, Jianxin Zhu, Fan Wu, Yu Fang, and Yan Xing. "A Switch Partial Turned OFF Cycle by Cycle Current Limiting Method for 3L-NPC Half-Bridge Inverters." IEEE Access 8 (2020): 15632–39. http://dx.doi.org/10.1109/access.2020.2967152.

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23

Shapiro, C. L., L. Ayash, I. J. Webb, et al. "Repetitive cycles of cyclophosphamide, thiotepa, and carboplatin intensification with peripheral-blood progenitor cells and filgrastim in advanced breast cancer patients." Journal of Clinical Oncology 15, no. 2 (1997): 674–83. http://dx.doi.org/10.1200/jco.1997.15.2.674.

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PURPOSE As an alternative to single-cycle cyclophosphamide, thiotepa, and carboplatin (CTCb) intensification, we evaluated the feasibility of administering one-quarter dose CTCb for four cycles with peripheral-blood progenitor-cell (PBPC) and filgrastim (granulocyte colony-stimulating factor [G-CSF]) in advanced-stage breast cancer patients. PATIENTS AND METHODS From June 1992 to August 1993, 20 stage IIIB (n = 7) and IV (n = 13) breast cancer patients received 78 cycles of induction with doxorubicin 90 mg/m2 by intravenous (IV) bolus with G-CSF 5 microg/kg/d by subcutaneous injection (SC) rep
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24

Abraham, Jame, Manish Agrawal, Susan Bakke, et al. "Phase I Trial and Pharmacokinetic Study of BMS-247550, an Epothilone B Analog, Administered Intravenously on a Daily Schedule for Five Days." Journal of Clinical Oncology 21, no. 9 (2003): 1866–73. http://dx.doi.org/10.1200/jco.2003.03.063.

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Purpose: The epothilones are a novel class of nontaxane microtubule-stabilizing agents. BMS-247550 is a semisynthetic analog of the natural product epothilone B. We conducted a phase I study administering BMS-247550 as a 1-hour intravenous infusion daily for 5 consecutive days every 21 days. Patients and Methods: Twenty-one patients received BMS-247550 without filgrastim in the first cycle. An additional six patients were enrolled at a starting dose of 8 mg/m2/d with filgrastim support. Twenty-one of the 27 patients had received prior paclitaxel, docetaxel, or both. Results: One hundred seven
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25

Laisk, Agu, and Gerald E. Edwards. "CO2 and Temperature-dependent Induction in C4 Photosynthesis: an Approach to the Hierarchy of Rate-limiting Processes." Functional Plant Biology 24, no. 4 (1997): 505. http://dx.doi.org/10.1071/pp97011.

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Rate-limiting processes for C4 photosynthesis were examined in Sorghum bicolor, an NADP-ME type species, and Amaranthus cruentus, an NAD-ME type C4 species, by studying the kinetics of transient changes in photosynthetic rates following rapid changes in CO2 or temperature. Primary responses (faster than 15 s) to increasing CO2 or temperature are considered direct effects on the turnover rate of the C4 cycle, whereas medium transient changes (2–3 min) are considered due to build-up of C4 cycle intermediates, and the slowest transient changes (20–30 min) are thought to be related to end product
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26

Leen, S. B., T. H. Hyde, C. H. H. Ratsimba, E. J. Williams, and I. R. McColl. "An investigation of the fatigue and fretting performance of a representative aero-engine spline coupling." Journal of Strain Analysis for Engineering Design 37, no. 6 (2002): 565–83. http://dx.doi.org/10.1243/030932402320950161.

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The fatigue behaviour of a representative high-performance aero-engine spline coupling is investigated under test conditions designed to simulate in-service conditions. The test load cycles consist of major cycle torque and axial load, simulating maximum thrust, combined with minor cycle rotating bending moment and fluctuating torque, simulating life-limiting conditions at take-off. The objective of the study is to develop understanding of the fatigue behaviour of the coupling over a range of loading conditions, including interaction between low-cycle fatigue, fretting fatigue and fretting wea
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27

Hao, Desiree, Quincy Chu, Stephen Welch, et al. "A phase I and pharmacokinetic (PK) study of continuous daily administration of P1446A-05, a potent and specific oral Cdk4 inhibitor." Journal of Clinical Oncology 30, no. 15_suppl (2012): 3013. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.3013.

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3013 Background: P1446A-05 is a novel oral inhibitor of Cdk4-D1, Cdk1-B, and Cdk9-T, and has been shown to inhibit tumor growth both in vitro and in vivo. Pharmacodynamic studies demonstrate that activation of Cdk1 reappears within 48 hours after P1446A-05 is withdrawn, suggesting the need for prolonged administration hence, we sought to evaluate the feasibility, safety and tolerability of a continuous daily schedule of P1446A-05 in patients (pts) with advanced malignancies. Methods: P1446A-05 was given at escalating doses of 75, 150, 250, 350 and 500mg. Samples were collected for PK at multip
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28

MATHIEU, CLAIRE, and DAVID B. WILSON. "The Min Mean-Weight Cycle in a Random Network." Combinatorics, Probability and Computing 22, no. 5 (2013): 763–82. http://dx.doi.org/10.1017/s0963548313000229.

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The mean weight of a cycle in an edge-weighted graph is the sum of the cycle's edge weights divided by the cycle's length. We study the minimum mean-weight cycle on the complete graph on n vertices, with random i.i.d. edge weights drawn from an exponential distribution with mean 1. We show that the probability of the min mean weight being at most c/n tends to a limiting function of c which is analytic for c ≤ 1/e, discontinuous at c = 1/e, and equal to 1 for c > 1/e. We further show that if the min mean weight is ≤ 1/(en), then the length of the relevant cycle is Θp(1) (i.e., it has a limit
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29

Kemp, S., M. Scholze, T. Ziehn, and T. Kaminski. "Limiting the parameter space in the Carbon Cycle Data Assimilation System (CCDAS)." Geoscientific Model Development 7, no. 4 (2014): 1609–19. http://dx.doi.org/10.5194/gmd-7-1609-2014.

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Abstract. Terrestrial ecosystem models are employed to calculate the sources and sinks of carbon dioxide between land and atmosphere. These models may be heavily parameterised. Where reliable estimates are unavailable for a parameter, it remains highly uncertain; uncertainty of parameters can substantially contribute to overall model output uncertainty. This paper builds on the work of the terrestrial Carbon Cycle Data Assimilation System (CCDAS), which, here, assimilates atmospheric CO2 concentrations to optimise 19 parameters of the underlying terrestrial ecosystem model (Biosphere Energy Tr
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30

Kemp, S., M. Scholze, T. Ziehn, and T. Kaminski. "Limiting the parameter space in the Carbon Cycle Data Assimilation System (CCDAS)." Geoscientific Model Development Discussions 7, no. 1 (2014): 659–89. http://dx.doi.org/10.5194/gmdd-7-659-2014.

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Abstract. Terrestrial ecosystem models are employed to calculate the sources and sinks of carbon dioxide between land and atmosphere. These models may be heavily parameterised. Where reliable estimates are unavailable for a parameter, it remains highly uncertain; uncertainty of parameters can substantially contribute to overall model output uncertainty. This paper builds on the work of the terrestrial Carbon Cycle Data Assimilation System (CCDAS), which, here, assimilates atmospheric CO2 concentrations to optimise 19 parameters of the underlying terrestrial ecosystem model (Biosphere Energy Tr
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31

Stueland, C. S., K. Gorden, and D. C. LaPorte. "The isocitrate dehydrogenase phosphorylation cycle. Identification of the primary rate-limiting step." Journal of Biological Chemistry 263, no. 36 (1988): 19475–79. http://dx.doi.org/10.1016/s0021-9258(19)77658-3.

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32

Chang, Maria, Elizabeth A. Parker, Tessa J. M. Muller, et al. "Changes in Cell-Cycle Kinetics Responsible for Limiting Somatic Growth in Mice." Pediatric Research 64, no. 3 (2008): 240–45. http://dx.doi.org/10.1203/pdr.0b013e318180e47a.

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33

Zhang, Guo Zhi, and Jun Jing Fu. "Study on Bending Mechanical Mechanism of ARB Specimen Based on Randomness." Advanced Materials Research 337 (September 2011): 650–54. http://dx.doi.org/10.4028/www.scientific.net/amr.337.650.

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The bending mechanical mechanism of ARB(accumulative roll bonding) specimen was studied. Based on macro-micro plastic theory, theoretical model of the limiting bending load of ARB specimen was established every cycle. Through comparing with the experiment of the reference, this model was verified. Moreover, based on reliability analysis method, considering the randomness of the grains and the dislocation, theoretical model of standard deviation of limiting bending load of ARB specimen was established. Furthermore, the critical curve theoretical model of plastic zone of ARB specimen was establi
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34

Xu, Weicong, Shuai Deng, Li Zhao, Dongpeng Zhao, and Ruihua Chen. "Identification of key affecting parameters of zeotropic working fluid on subcritical organic Rankine cycle according limiting thermodynamic cycle." Energy Conversion and Management 197 (October 2019): 111884. http://dx.doi.org/10.1016/j.enconman.2019.111884.

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35

Duston, J., and R. L. Saunders. "Effect of 6-, 12-, and 18-month Photoperiod Cycles on Smolting and Sexual Maturation in Juvenile Atlantic Salmon (Salmo salar)." Canadian Journal of Fisheries and Aquatic Sciences 49, no. 11 (1992): 2273–80. http://dx.doi.org/10.1139/f92-249.

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The results support the hypothesis that the commencement of smolting can occur during the decreasing phase of the annual photoperiod cycle, and sexual maturation during the increasing phase of the cycle, provided individuals have attained certain (unknown) growth thresholds. Thereafter the completion of smolting is entrained by the increasing phase of the photoperiod cycle, and sexual maturation by the decreasing phase. Three groups of Atlantic salmon (Salmo salar) were raised in freshwater for over 2 yr from the eyed egg stage under photoperiod cycles of either 6-, 12- (control), or 18-mo per
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36

Wiśniewski, Jan, Krzysztof Rogowski, Konrad Gumowski, and Jacek Szumbarski. "Wind tunnel comparison of four VAWT configurations to test load-limiting concept and CFD validation." Wind Energy Science 6, no. 1 (2021): 287–94. http://dx.doi.org/10.5194/wes-6-287-2021.

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Abstract. The article describes results of experimental wind tunnel testing of four different straight-bladed vertical axis wind turbine model configurations. The experiment tested a novel concept of vertically dividing and azimuthally shifting a turbine rotor into two parts with a specific uneven height division in order to limit cycle amplitudes and average cycle values of bending moments at the bottom of the turbine shaft to increase product lifetime, especially for industrial-scale turbines. Testing reduction effects of simultaneously including a vertical gap between turbine rotor levels,
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37

Neidhart, J. A., W. Kohler, C. Stidley, et al. "Phase I study of repeated cycles of high-dose cyclophosphamide, etoposide, and cisplatin administered without bone marrow transplantation." Journal of Clinical Oncology 8, no. 10 (1990): 1728–38. http://dx.doi.org/10.1200/jco.1990.8.10.1728.

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Forty-two patients with advanced malignancy judged unlikely to respond to standard treatment received high-dose combination chemotherapy with cyclophosphamide, etoposide, and cisplatin in a phase I trial. Twenty-two of these patients who had at least a partial response (PR) to the first cycle of therapy received a second cycle, and eight patients received three or more cycles of therapy. Bone marrow replacement was not used. The maximum-tolerated doses (MTDs) were cyclophosphamide 2.5 g/m2 on days 1 and 2; etoposide 500 mg/m2 on days 1, 2, and 3; and cisplatin 50 mg/m2 on days 1, 2, and 3. Hem
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38

Driver, Oliver G. A., Marc E. J. Stettler, and Edward Gryspeerdt. "Factors limiting contrail detection in satellite imagery." Atmospheric Measurement Techniques 18, no. 5 (2025): 1115–34. https://doi.org/10.5194/amt-18-1115-2025.

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Abstract. Contrails (ice clouds, originally line-shaped after initiation by aircraft exhaust) provide a significant warming contribution to the overall climate impact of aviation. This makes reducing them a key target for future climate strategies in the sector. Identifying pathways for contrail reduction requires accurate models of contrail formation and life cycle, which in turn need suitable observations to constrain them. Infrared imagers on geostationary satellites provide widespread contrail observations, with sufficient time resolution to observe the evolution of their properties. Howev
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39

Taylor, M. "The Product-Cycle Model: A Critique." Environment and Planning A: Economy and Space 18, no. 6 (1986): 751–61. http://dx.doi.org/10.1068/a180751.

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The product-cycle model is an important explanatory device that has been used extensively in geography. However, it is also a model with significant limiting assumptions that have not been adequately taken into account when it has been used. In this paper the problems and limitations imposed on the model by the assumptions it contains are outlined. Six broad aspects of the model are addressed: the ambiguity of the enterprise context implied in the model; its treatment of the processes of invention and innovation; its simplification of the nature of products; assumptions about scale, labour, an
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40

Lyu, Jiaying, Emily Curran, and Yuan Ji. "Bayesian Adaptive Design for Finding the Maximum Tolerated Sequence of Doses in Multicycle Dose-Finding Clinical Trials." JCO Precision Oncology, no. 2 (November 2018): 1–19. http://dx.doi.org/10.1200/po.18.00020.

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Purpose Statistical designs for traditional phase I dose-finding trials consider dose-limiting toxicity in the first cycle of treatment. In reality, patients often go through multiple cycles of treatment and may experience toxicity events in more than one cycle. Therefore, it is desirable to identify the maximum tolerated sequence of three doses across three cycles of treatment. Methods Motivated by a three-cycle dose-finding clinical trial for a rare cancer with a JAK inhibitor, we proposed and implemented a simple Bayesian adaptive dose-cycle finding (BaSyc) design that allows intercycle and
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41

Cramer, Stuart, Elizabeth Ann Gilger, Susan Burlingame, et al. "ADVL1514, a phase 1 study of ABI-009 (nab-sirolimus) in pediatric patients with recurrent or refractory solid tumors, including CNS tumors as a single agent and in combination with temozolomide and irinotecan: A Children’s Oncology Group pediatric early-phase clinical trial network study." Journal of Clinical Oncology 40, no. 16_suppl (2022): 10022. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.10022.

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10022 Background: nab-Sirolimus (formerly know ABI-009 and nab-rapamycin) is a novel human albumin-bound preparation of sirolimus, a potent mTOR inhibitor. We report results of a Phase I study of ABI-009 alone and in combination with irinotecan and temozolomide in children with relapsed/refractory solid or CNS tumors. Methods: Patients (age 1-21 years) with relapsed/refractory solid or CNS tumors were eligible. Using a rolling 6 design, ABI-009 was administered intravenously as a single agent on Days 1 and 8 of cycle 1 (cycle = 21d), then subsequent cycles ABI-009 was administered in combinati
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Молоков, К. А., В. В. Новиков, and А. И. Мамонтов. "CALCULATION METHOD FOR EVALUATING THE LIMITING STRESS AMPLITUDES OF CYCLES IN CASE OF INHOMOGENEITY OF THE STRUCTURAL AND MECHANICAL CHARACTERISTICS OF WELDED JOINTS." ВЕСТНИК ВОРОНЕЖСКОГО ГОСУДАРСТВЕННОГО ТЕХНИЧЕСКОГО УНИВЕРСИТЕТА 19, no. 5 (2023): 121–30. http://dx.doi.org/10.36622/vstu.2023.19.5.017.

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в результате перегрузок при действии внешней циклической нагрузки на конструкции в области концентраторов напряжений повышаются степень асимметрии цикла, уровень максимальных напряжений и деформаций в областях значительной неоднородности, имеющей место особенно при сварке термоупрочненных сталей. Учитывая это, важно уметь строить диаграммы предельных амплитуд напряжений циклов с учетом структурной и механической неоднородности для сварных соединений. Оценка таких предельных амплитуд напряжений для действующих циклических напряжений на участках сварного соединения может быть выполнена с помощью
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Agustami, Agustami. "PENGGUNAAN MODEL PEMBELAJARAN KOOPERATIF TIPE JIGSAW UNTUK MENINGKATKAN KEMAMPUAN SISWA PADA MATERI LIMIT FUNGSI ALJABAR PADA SMA NEGERI 1 KEMBANG TANJONG." Jurnal Sosial Humaniora Sigli 5, no. 1 (2022): 63–67. http://dx.doi.org/10.47647/jsh.v5i1.632.

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The purpose of this study was to determine the improvement of students' abilities in class XII MIPA-4 material on the limit of algebraic functions in Mathematics by using the Jigsaw type cooperative learning model at SMA Negeri 1 Kembang Tanjong. The benefit of this research is to make it easier for students to learn, especially Mathematics, especially the material on the limit of algebraic functions by using the Jigsaw type of cooperative learning model. The subjects in this classroom action research are students of class XII MIPA-4 SMA Negeri 1 Kembang Tanjong for the academic year 2021/2022
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Gyeong-Ho Lee, Kwon-Bae Park, Jungwook Sim, et al. "Hybrid Superconducting Fault Current Limiter of the First Half Cycle Non-Limiting Type." IEEE Transactions on Applied Superconductivity 19, no. 3 (2009): 1888–91. http://dx.doi.org/10.1109/tasc.2009.2017873.

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Gorodokin, Vladimir, Vadim Mavrin, Zlata Almetova, and Elena Shepeleva. "Method to ensure crossing capacity when limiting the cycle time and roadway width." Transportation Research Procedia 50 (2020): 167–73. http://dx.doi.org/10.1016/j.trpro.2020.10.021.

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Hamilton, Scott A., and Dennis D. Murphy. "Analysis of Limiting Factors Across the Life Cycle of Delta Smelt (Hypomesus transpacificus)." Environmental Management 62, no. 2 (2018): 365–82. http://dx.doi.org/10.1007/s00267-018-1014-9.

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Oldyrev, P. P. "Diagram of limiting stresses in the asymmetric high-cycle bending of reinforced plates." Mechanics of Composite Materials 21, no. 1 (1985): 56–58. http://dx.doi.org/10.1007/bf00611808.

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Bobyr', N. I., I. N. Grigor'ev, O. N. Mukoida, and S. N. Shukaev. "Deformation resistance and limiting state of structural materials in multiaxial low-cycle deformation." Strength of Materials 22, no. 10 (1990): 1393–99. http://dx.doi.org/10.1007/bf00767218.

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Hamm, J. T., D. Richards, R. K. Ramanathan, et al. "Dose-finding study of NKTR-102 in combination with cetuximab." Journal of Clinical Oncology 27, no. 15_suppl (2009): e13503-e13503. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e13503.

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e13503 Background: NKTR-102 is an advanced polymer conjugate of irinotecan with broad single agent activity and a unique pharmacokinetic (pk) profile. The apparent half-life of the active metabolite SN-38 in patients (pts) administered NKTR-102 is approximately 50 days. NKTR-102 in combination with cetuximab was evaluated in pts with refractory solid tumors to define the maximum tolerated dose (MTD). Methods: NKTR-102 was infused over 90 minutes every 3 weeks per cycle. Cetuximab was infused over 2 hours at 400mg/m2 on day 1 followed by a weekly 1 hour infusion at 250mg/m2. Cohorts of 3 -12 pt
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Zaniewski, Taylor M., Allison M. Gicking, John Fricks, and William O. Hancock. "A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle." Journal of Biological Chemistry 295, no. 52 (2020): 17889–903. http://dx.doi.org/10.1074/jbc.ra120.014961.

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The kinesin-3 family contains the fastest and most processive motors of the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transitions that comprise the chemomechanical cycle and give rise to their unique properties are poorly understood. We used stopped-flow fluorescence spectroscopy and single-molecule motility assays to delineate the chemomechanical cycle of the kinesin-3, KIF1A. Our bacterially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivity behavior similar to WT KIF1A. We establishe
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