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Journal articles on the topic 'Limonin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Yang, Jingguo, Yuhong Hu, and Kuan Chang. "Limonin Derivatives via Hydrogenation: Structural Identification and Anti-Inflammatory Activity Evaluation." Applied Sciences 12, no. 21 (2022): 11169. http://dx.doi.org/10.3390/app122111169.

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Limonin is a natural compound which is rich in the fruit of various plants of the Rutaceae family and demonstrated to have a wide range of biological activities. In this work, seven limonin derivatives were successfully synthesized by hydrogenation of limonin, using different reducing agents (sodium cyanoborohydride, lithium aluminum hydride, and sodium borohydride). The chemical structure of the seven derivatives was characterized and identified by a series of techniques, including HR-ESI-MS, 1H-NMR, 13C-NMR, 2D-NMR, and IR. Among the seven limonin derivatives, six limonin derivatives were fo

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2

SETHI, A. P. S., M. SINGH, M. WADHWA, et al. "Impact of kinnow peel and nano-limonin on the performance and meat quality of commercial broilers." Indian Journal of Animal Sciences 90, no. 6 (2020): 917–22. http://dx.doi.org/10.56093/ijans.v90i6.105005.

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This study was taken up with the objective to assess the effect of limonin on the performance of commercial broilers and quality of meat. Day old chicks (200) were divided into 8 groups, each group contained 4 replicates of 6 chicks each in equal sex ratio. The iso-nitrogenous and iso-caloric diets were fed for 35 days, i.e. starter, grower and finisher phase. Kinnow peel powder (KPP) and solid lipid nanoparticles (SLN) of kinnow peel powder containing 7.47 mg limonin/g was added in the required quantity of feed to supply 0, 0.5, 1.0 and 1.5 mg limonin/bird/day. The data was analyzed using 2Ã—

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3

AMARENDRA, PATRA, K. MISRA SWAPAN, and K. CHAUDHURI SWAPAN. "Constituents of Limonia acidissima. Applications of Two-dimensional NMR Spectroscopy in Structure Elucidation." Journal of Indian Chemical Society Vol. 65, Mar 1988 (1988): 205–8. https://doi.org/10.5281/zenodo.6076015.

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Department of Chemistry, University College of Science, Calcutta-700 009 <em>Manuscript  received 19 November 1987, accepted 27 January 1988</em> The leaves and stems of <em>Limonia acidissima</em> afforded coumarins (luvangetin, xanthotoxin and marmesin), triterpenoids (lupeol and limonin) and steroids (sitosterol <em>O</em>-\(\beta\)-D glucoside). These compounds have been characterised by their spectral (uv, ir. <sup>1</sup>H- and <sup>12</sup>C-nmr, mass) characteristics. Detailed proton and carbon 13 spectral analyses of limonin have been made using two-dimensional nmr spectrosc

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4

Fan, Zhang, Luo, et al. "Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics." Molecules 24, no. 20 (2019): 3679. http://dx.doi.org/10.3390/molecules24203679.

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Limonin is a natural tetracyclic triterpenoid compound, which widely exists in Euodia rutaecarpa (Juss.) Benth., Phellodendron chinense Schneid., and Coptis chinensis Franch. Its extensive pharmacological effects have attracted considerable attention in recent years. However, there is no systematic review focusing on the pharmacology, toxicity, and pharmacokinetics of limonin. Therefore, this review aimed to provide the latest information on the pharmacology, toxicity, and pharmacokinetics of limonin, exploring the therapeutic potential of this compound and looking for ways to improve efficacy

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5

Zhang, Wei-Feng, Cheng-Wei Ruan, Jun-Bo Wu, Guo-Liang Wu, Xiao-Gan Wang, and Hong-Jin Chen. "Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling." World Journal of Clinical Oncology 15, no. 2 (2024): 317–28. http://dx.doi.org/10.5306/wjco.v15.i2.317.

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BACKGROUND Limonin is one of the most abundant active ingredients of Tetradium ruticarpum . It exerts antitumor effects on several kinds of cancer cells. However, whether limonin exerts antitumor effects on colorectal cancer (CRC) cells and cancer stem-like cells (CSCs), a subpopulation responsible for a poor prognosis, is unclear. AIM To evaluate the effects of limonin on CSCs derived from CRC cells. METHODS CSCs were collected by culturing CRC cells in serum-free medium. The cytotoxicity of limonin against CSCs and parental cells (PCs) was determined by cholecystokinin octapeptide-8 assay. T

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6

Kang, Jung-Il, Youn Kyoung Choi, Sang-Chul Han, et al. "Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells." Nutrients 14, no. 24 (2022): 5358. http://dx.doi.org/10.3390/nu14245358.

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Hair loss remains a significant problem that is difficult to treat; therefore, there is a need to identify safe natural materials that can help patients with hair loss. We evaluated the hair anagen activation effects of limonin, which is abundant in immature citrus fruits. Limonin increased the proliferation of rat dermal papilla cells (rDPC) by changing the levels of cyclin D1 and p27, and increasing the number of BrdU-positive cells. Limonin increased autophagy by decreasing phosphorylated mammalian target of rapamycin levels and increasing the phospho-Raptor, ATG7 and LC3B. Limonin also act

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7

Jin, Jie, Xinhuang Lv, Ben Wang та ін. "Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2". Oxidative Medicine and Cellular Longevity 2021 (9 листопада 2021): 1–15. http://dx.doi.org/10.1155/2021/7292512.

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Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common forms of arthritis. Limonin (Lim) is extracted from lemons and other citrus fruits. Limonin has been reported to have anti-inflammatory effects, while inflammation is a major cause of OA; thus, we propose that limonin may have a therapeutic effect on OA. In this study, the therapeutic effect of limonin on OA was assessed in chondrocytes in vitro in IL-1β induced OA and in the destabilization of the medial meniscus (DMM) mice in vivo. The Nrf2/HO-1/NF-κB signaling pathway was evaluated to illustrate the wor

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8

Yu*, Jun, Romeo Toledo, Rakesh Singh, Leonard Pike, and Bhimanagouda Patil. "Supercritical Fluid Extraction of Limonoids from Grapefruit Seeds." HortScience 39, no. 4 (2004): 806D—806. http://dx.doi.org/10.21273/hortsci.39.4.806d.

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Grapefruit seeds were studied for the extraction of limonoids using supercritical CO2 extraction (SC-CO2) technique. Limonin aglycone was successfully extracted with SC-CO2 directly from grapefruit seeds; and the limonin glycoside was extracted using SC-CO2 and ethanol as co-solvent from the spent seeds after the extraction of limonin aglycone. In an effort to optimize the extraction conditions of limonin aglycone, pressure, temperature, time effects were investigated. Various times of extraction, CO2 flow rate and the feeding modes of CO2 were also employed to obtain the highest yield of limo

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9

Liu, C., J. Liu, Y. Rong, N. Liang, and L. Rong. "Aqueous extraction of limonin from Citrus reticulate Blanco." Czech Journal of Food Sciences 30, No. 4 (2012): 364–68. http://dx.doi.org/10.17221/108/2011-cjfs.

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The replacement of organic solutions in the extraction of limonin from citrus seeds with an alkaline solution was investigated. This method was based on the reversible conversion of limonin to limonoate A-ring lactone via ring-opening of D-ring lactone at different pH values. The extraction conditions, optimised using Taguchi experimental design, were as follows: pH 11, temperature 70&deg;C, alkaline solution/seeds ratio 20:1 (v/w), ultrasonic power 800 W for 30 minutes. A yield of 7.5 mg/g (limonin/citrus seeds) of 98% pure limonin was obtained. &nbsp;

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10

Takahashi, K., M. Obayashi, and M. Nakatani. "Structure of limonin." Acta Crystallographica Section C Crystal Structure Communications 46, no. 3 (1990): 425–27. http://dx.doi.org/10.1107/s0108270189007225.

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11

Zhang, Jun, Zhiqiang Yang, Yan Liang, et al. "Effects of Postharvest Time, Heat Treatment, pH and Filtration on the Limonin Content in Newhall Navel Orange (Citrus sinensis Osbeck cv. Newhall) Juice." Molecules 23, no. 10 (2018): 2691. http://dx.doi.org/10.3390/molecules23102691.

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Delayed bitterness causes severe economic loss in citrus juice industry worldwide, which is mostly due to the formation of limonoid compounds, especially limonin, in juice. In this study, effects of postharvest time of fruits, heat treatment, pH and filtration of juice on limonin content in Newhall navel orange (Citrus sinensis Osbeck cv. Newhall) juice were investigated. Our research indicated for the first time that: (1) limonin content in juice would gradually increase to a maximal level and then remained almost constant thereafter as storage time going on, whereas the maximum constant valu

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12

Lee, Seung Taek, Jong Yeong Lee, Ha Eun Kim, Jun-Young Park, and Jin Kyeong Choi. "Limonin Exhibits Anti-Inflammatory Effects by Inhibiting mTORC1 and Mitochondrial Reactive Oxygen Species in Psoriatic-like Skin Inflammation." Antioxidants 13, no. 12 (2024): 1541. https://doi.org/10.3390/antiox13121541.

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Psoriasis is a chronic inflammatory skin disorder characterized by abnormal immune responses and keratinocyte hyperproliferation. Limonin, a bioactive compound found in citrus fruits, has anti-inflammatory properties in various models; however, its effects on psoriasis are not fully understood. We investigated the therapeutic potential of limonin in a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced psoriasis mouse model. Mice were treated with TPA to induce psoriasis-like skin lesions, followed by intraperitoneal administration of limonin (200 or 400 μg/mouse) for six days. The results show

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13

Breksa, Andrew P., and Gary D. Manners. "Evaluation of the Antioxidant Capacity of Limonin, Nomilin, and Limonin Glucoside." Journal of Agricultural and Food Chemistry 54, no. 11 (2006): 3827–31. http://dx.doi.org/10.1021/jf060901c.

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14

Mesquita, Estela, Eliane Barbosa, Maria Rita Olivati Estevam, Daniela Kharfan, Alberto José Cavalheiro, and Magali Monteiro. "The influence of rootstock and extraction setting on the Limonin and Flavonoids levels in orange juice during ripeness." Brazilian Journal of Development 8, no. 11 (2022): 74904–20. http://dx.doi.org/10.34117/bjdv8n11-281.

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The influence of rootstock, maturity and extraction settings on limonin, hesperidin and narirutin levels of orange juice was evaluated. A liquid chromatographic method to determine limonin was developed and validated. The linear range was 0.410 to 61.5 µg.mL-1, with a linear correlation coefficient higher than 0.999. The limit of detection was 0.144 µg.mL-1and limit of quantification 0.363 µg; precision showed RSD≤5.0% and accuracy was from 92.6 to 100.4%. Limonin was identified in Pêra-Rio orange juices from Cleopatra mandarin and Rangpur lime rootstocks extracted in the NFC and FCOJ settings

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15

Salom, S. M., J. A. Carlson, B. N. Ang, D. M. Grosman, and E. R. Day. "Laboratory Evaluation of Biologically-Based Compounds as Antifeedants for the Pales Weevil, Hylobius pales (Herbst) (Coleoptera: Curculionidae)." Journal of Entomological Science 29, no. 3 (1994): 407–19. http://dx.doi.org/10.18474/0749-8004-29.3.407.

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Twenty plant-produced compounds or mixtures and one insect-produced semiochemical were evaluated as potential antifeedants for the pales weevil, Hylobius pales (Herbst). Initially, a choice laboratory feeding bioassay was conducted to screen the compounds and identify antifeedant activity. This was followed by a no-choice dose-response bioassay to further evaluate the most active compounds from the choice test. In the choice test, nine compounds inhibited feeding by H. pales on white pine, Pinus strobus L., twigs after 24 h: borneol, bornyl acetate, cucurbitacin, limonin, myrcene, neem extract

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16

Nurhaliza, Nurhaliza Nurhaliza, Rudiyansyah Rudiyansyah, and Harlia Harlia. "PERBANDINGAN METODE EKSTRAKSI TERHADAP KANDUNGAN LIMONIN PADA EKSTRAK METANOL BIJI JERUK SAMBAL (Citrus microcarpa Bunge) (COMPARISON OF EXTRACTION METHODS FOR LIMONIN CONTENT IN METHANOL EXTRACT OF SEEDS OF Citrus microcarpa Bunge)." Indonesian Journal of Pure and Applied Chemistry 5, no. 1 (2022): 20. http://dx.doi.org/10.26418/indonesian.v5i1.53663.

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Limonin is a limonoid compound belonging to a terpenoid and it is found in Citrus plants including in the seeds of C. microcarpa. According to literature, limonin has been isolated by different methods from various Citrus plants with variable concentration. In this study, three extraction methods, maceration, soxhletation, and sonication were compared to examine a limonin concentration from the seeds of C. microcarpa. The purpose of this study is to determine the best extraction method which is able to give the highest concentration of limonin in the methanol extract. On the basis of phytochem

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17

Phucharoenrak, Pakkapong, Chawanphat Muangnoi, and Dunyaporn Trachootham. "A Green Extraction Method to Achieve the Highest Yield of Limonin and Hesperidin from Lime Peel Powder (Citrus aurantifolia)." Molecules 27, no. 3 (2022): 820. http://dx.doi.org/10.3390/molecules27030820.

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Green extraction is aimed at reducing energy consumption by using renewable plant sources and environmentally friendly bio-solvents. Lime (Citrus aurantifolia) is a rich source of flavonoids (e.g., hesperidin) and limonoids (e.g., limonin). Manufacturing of lime products (e.g., lime juice) yields a considerable amount of lime peel as food waste that should be comprehensively exploited. The aim of this study was to develop a green and simple extraction method to acquire the highest yield of both limonin and hesperidin from the lime peel. The study method included ethanolic-aqueous extraction an

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18

Wang, Xi, Long He, Sa Wang, Yunsen Zhu, Liming Hu, and Wenting You. "Influence of ultrasonic treatment parameters on extraction yield of limonin from Wenling Gaocheng peels analysed by HPLC-UV." International Food Research Journal 31, no. 3 (2024): 614–23. http://dx.doi.org/10.47836/ifrj.31.3.07.

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Ultrasound-assisted extraction (UAE) is a promising technique for isolating bioactive compounds from plant materials, as ultrasound disrupts cell walls through mechanical effects, and facilitates the release of cellular constituents. Despite its growing popularity, the efficiency of UAE for extracting limonin from citrus peels, particularly Wenling Gaocheng, remains understudied. In the present work, we systematically explored the influence of various operational parameters on the yield of limonin using UAE. The limonin content was quantified using a Waters 2695 HPLC system coupled with a Wate

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19

Zhou, Yu, Yuxiang Zhang, Detian Mu, et al. "Selection of Reference Genes in Evodia rutaecarpa var. officinalis and Expression Patterns of Genes Involved in Its Limonin Biosynthesis." Plants 12, no. 18 (2023): 3197. http://dx.doi.org/10.3390/plants12183197.

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E. rutaecarpa var. officinalis is a traditional Chinese medicinal plant known for its therapeutic effects, which encompass the promotion of digestion, the dispelling of cold, the alleviation of pain, and the exhibition of anti-inflammatory and antibacterial properties. The principal active component of this plant, limonin, is a potent triterpene compound with notable pharmacological activities. Despite its significance, the complete biosynthesis pathway of limonin in E. rutaecarpa var. officinalis remains incompletely understood, and the underlying molecular mechanisms remain unexplored. The m

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Phucharoenrak, Pakkapong, Chawanphat Muangnoi, and Dunyaporn Trachootham. "Metabolomic Analysis of Phytochemical Compounds from Ethanolic Extract of Lime (Citrus aurantifolia) Peel and Its Anti-Cancer Effects against Human Hepatocellular Carcinoma Cells." Molecules 28, no. 7 (2023): 2965. http://dx.doi.org/10.3390/molecules28072965.

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Lime peels are food waste from lime product manufacturing. We previously developed and optimized a green extraction method for hesperidin-limonin-rich lime peel extract. This study aimed to identify the metabolomics profile of phytochemicals and the anti-cancer effects of ethanolic extract of lime (Citrus aurantifolia) peel against liver cancer cells PLC/PRF/5. The extract’s metabolomics profile was analyzed by using LC-qTOF/MS and GC-HRMS. The anti-cancer effects were studied by using MTT assay, Annexin-PI assay, and Transwell-invasion assay. Results show that the average IC50(s) of hesperidi

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Yamashita, Shuji, Akito Naruko, Yuki Nakazawa, Le Zhao, Yujiro Hayashi, and Masahiro Hirama. "Total Synthesis of Limonin." Angewandte Chemie International Edition 54, no. 29 (2015): 8538–41. http://dx.doi.org/10.1002/anie.201503794.

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Yamashita, Shuji, Akito Naruko, Yuki Nakazawa, Le Zhao, Yujiro Hayashi, and Masahiro Hirama. "Total Synthesis of Limonin." Angewandte Chemie 127, no. 29 (2015): 8658–61. http://dx.doi.org/10.1002/ange.201503794.

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23

Li, Yi, Runan Zhao, Yan Li, and Zhiqin Zhou. "Limonin Enhances the Antifungal Activity of Eugenol Nanoemulsion against Penicillium Italicum In Vitro and In Vivo Tests." Microorganisms 9, no. 5 (2021): 969. http://dx.doi.org/10.3390/microorganisms9050969.

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Penicillium italicum, the cause of citrus blue mold, is a pathogenic fungus that seriously affects the postharvest quality of citrus fruit and causes serious economic loss. In this study, a eugenol nanoemulsion containing limonin, an antimicrobial component from citrus seeds, was prepared using a high-pressure microfluidizer and the antifungal activity of the nanoemulsions against P. italicum was evaluated based on the conidial germination rate, mycelial growth, and scanning electron microscopy analysis. The results showed that the minimum inhibitory concentration and the inhibition rate of li

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Widayanti, Setyo, Rudiyansyah Rudiyansyah, and Andi Hairil Alimuddin. "PENENTUAN STRUKTUR SENYAWA ANTIOKSIDAN LIMONOID DARI BIJI JERUK SAMBAL (Citrus microcarpa Bunge) KALIMANTAN BARAT." Indonesian Journal of Pure and Applied Chemistry 1, no. 3 (2019): 77. http://dx.doi.org/10.26418/indonesian.v1i3.34193.

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Limonoid has been isolated from orange seeds of Citrus microcarpa Bunge using extraction and partitioning methods. It is a yellowish-white crystal with a melting point of 276-277 oC. Based on the phytochemical analysis and FTIR spectroscopy, 1H NMR and compared with the literature, the compound is limonin which is a triterpenoid. The purpose of this study was to determine the structure and evaluate antioxidant activity of the limonin. The antioxidant activity by DPPH obtained IC50 value of limonin was 199.18 ppm. Whereas, the test antioxidant activity by FRAP method using a comparative solutio

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Jia, Chengshu, Bin Hu, Yingying Ji, et al. "Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties." Letters in Drug Design & Discovery 17, no. 3 (2020): 285–99. http://dx.doi.org/10.2174/1570180816666181113102359.

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Background: Limonoids represent an important class of natural products which possess a broad range of biological activities. Albeit their enormous potentials as therapeutic candidates, they usually suffer from low bioavailability, poor aqueous solubility and relatively weak biological activities which result in significant challenges in the clinic applications. Therefore, the exploration and development of novel limonin derivatives with improved drug-like properties through the structural modifications recently have attracted great attention in the biological and medicinal chemistry field. Met

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RAM, BHANU P., LARRY JANG, LORELEI MARTINS, and PRITHIPAL SINGH. "An Improved Enzyme Immunoassay for Limonin." Journal of Food Science 53, no. 1 (1988): 311–12. http://dx.doi.org/10.1111/j.1365-2621.1988.tb10245.x.

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Yamashita, Shuji, Akito Naruko, Yuki Nakazawa, Le Zhao, Yujiro Hayashi, and Masahiro Hirama. "ChemInform Abstract: Total Synthesis of Limonin." ChemInform 46, no. 38 (2015): no. http://dx.doi.org/10.1002/chin.201538199.

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28

Yang, Qi, Feng Zhang, Shou-Hong Gao, Lian-Na Sun, and Wan-Sheng Chen. "Determination of Bioactive Compounds in Cortex Phellodendri by High-Performance Liquid Chromatography." Journal of AOAC INTERNATIONAL 93, no. 3 (2010): 855–61. http://dx.doi.org/10.1093/jaoac/93.3.855.

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Abstract An HPLC method combined with a photodiode array detector was developed for quantitative determination of five bioactive compounds that belong to two subclasses, including limonin, phellodendrine, jatrorrhizine, palmatine, and berberine in Cortex Phellodendri. The analysis was performed on an Agilent Diamonsil C18 column (4.6 250 mm, 5 m) using a gradient of acetonitrile and 0.3 aqueous diethylamine phosphate (v/v), a flow rate of 0.8 mL/min, and a detection wavelength of 220 nm. The calibration curve was linear over the range of 2.5100.0 g/mL for both phellodendrine and jatrorrhizine,

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Liu, Yeqian, Hong Li, Lei Chen, et al. "Mechanism and Pharmacodynamic Substance Basis of Raw and Wine-Processed Evodia rutaecarpa on Smooth Muscle Cells of Dysmenorrhea Mice." Pain Research and Management 2023 (June 1, 2023): 1–14. http://dx.doi.org/10.1155/2023/7711988.

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Objectives. Evodia rutaecarpa (ER) is a well-known herbal Chinese medicine traditionally used for analgesia in dysmenorrhea, headaches, abdominal pain, etc. Notably, the analgesic effect of wine-processed Evodia rutaecarpa (PER) was more potent than that of raw ER. This research aimed to investigate the mechanism and pharmacodynamic substance basis of raw ER and PER on smooth muscle cells of dysmenorrhea mice. Methods. Metabolomics methods based on UPLC-Q-TOF-MS were utilized to analyse the differential components of ER before and after wine processing. Afterwards, the uterine smooth muscle ce

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Liang, Y., L. Xie, X. D. Liu, Y. Z. Hu, T. Lu, and G. J. Wang. "Gender differences in limonin pharmacokinetics in rats." European Journal of Drug Metabolism and Pharmacokinetics 30, no. 4 (2005): 243–48. http://dx.doi.org/10.1007/bf03190627.

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Mart�nez-Madrid, C., A. Manj�n, and J. L. Iborra. "Degradation of limonin by entrappedRhodococcus fascians cells." Biotechnology Letters 11, no. 9 (1989): 653–58. http://dx.doi.org/10.1007/bf01025277.

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Breksa III, Andrew P., Marlene B. Hidalgo, and Rosalind Y. Wong. "Stability of limonin glucoside in beverage matrices." Journal of the Science of Food and Agriculture 88, no. 12 (2008): 2194–200. http://dx.doi.org/10.1002/jsfa.3344.

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Matsumoto, Ryoji, Daisuke Ikematsu, Terutaka Yoshioka, and Masashi Yamamoto. "Quantification of Limonin Glucoside, Phytonutrient Component, in Citrus by Means of an Enzyme Immunoassay Using Anti-limonin Antiserum." Horticultural Research (Japan) 7, no. 4 (2008): 481–89. http://dx.doi.org/10.2503/hrj.7.481.

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Gu, Min, Jin Sun, Ce Qi, et al. "The gastrointestinal fate of limonin and its effect on gut microbiota in mice." Food & Function 10, no. 9 (2019): 5521–30. http://dx.doi.org/10.1039/c9fo01274e.

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Zhang, Aihua, Huiyu Wang, Hui Sun, et al. "Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis." Food & Function 6, no. 11 (2015): 3540–49. http://dx.doi.org/10.1039/c5fo00489f.

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Arabi, Faten Abu, Nawal H. Al Bahtiti, Mohammed h. Kailani, Ibrahim Abderahman, Zahra O. Akfaquri, and Hind H. Al Abdallat. "A Comparative LC/MS Analysis of Jordanian Lemon (Citrus limon): Peels, Pulp, Leaves, Branches, and Juice." Journal of Posthumanism 5, no. 6 (2025): 1648–57. https://doi.org/10.63332/joph.v5i6.2262.

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Citrus limon (lemon) is important in pharmaceutical, restorative, and culinary (solid nourishment). It has uncommon properties and distinctive chemical compositions. The advantageous organic action of C. limon is decided by its tall substance of phenolic compounds, basically flavonoids (e.g., diosmin, hesperidin, limonin) and phenolic acids (e.g., ferulic, synaptic, p-hydroxybenzoic acids). The fundamental oil contains bioactive monoterpenoids such as D-limonene, Î²-pinene, and Î³-terpinene. As of late, deductively demonstrated restorative exercises of C. limon incorporate anti-inflammatory, a

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Glabasnia, Anneke, та Thomas Hofmann. "On the non-enzymatic liberation of limonin and C17-epilimonin from limonin-17-β-d-glucopyranoside in orange juice". European Food Research and Technology 228, № 1 (2008): 55–63. http://dx.doi.org/10.1007/s00217-008-0906-y.

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Sun, Di, Yifan Liu, Zihui Jin, et al. "Preparation of limonin monoclonal antibody and establishment of a sensitive icELISA for analyzing limonin in citrus and herbal samples." Food Chemistry 447 (July 2024): 138989. http://dx.doi.org/10.1016/j.foodchem.2024.138989.

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Muñoz, Mariela, Jessica Holtheuer, Lorena Wilson, and Paulina Urrutia. "Grapefruit Debittering by Simultaneous Naringin Hydrolysis and Limonin Adsorption Using Naringinase Immobilized in Agarose Supports." Molecules 27, no. 9 (2022): 2867. http://dx.doi.org/10.3390/molecules27092867.

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Naringin and limonin are the two main bitter compounds of citrus products such as grapefruit juice. The aim of this investigation was to evaluate the reduction in both bitter components simultaneously using a combined biochemical and physical approach. The proposed strategy was based on the use of heterofunctional supports with glyoxyl groups that allow for the covalent immobilization of naringinase, which hydrolyses naringin and alkyl groups that allow for the adsorption of limonin. The supports were butyl-glyoxyl agarose (BGA) and octyl-glyoxyl agarose (OGA), which were characterized in term

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Deng, Yujie, Yudong Fu, Shumin Xu, et al. "Detection and Structural Characterization of Nucleophiles Trapped Reactive Metabolites of Limonin Using Liquid Chromatography-Mass Spectrometry." Journal of Analytical Methods in Chemistry 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/3797389.

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Limonin (LIM), a furan-containing limonoid, is one of the most abundant components of Dictamnus dasycarpus Turcz. Recent studies demonstrated that LIM has great potential for inhibiting the activity of drug-metabolizing enzymes. However, the mechanisms of LIM-induced enzyme inactivation processes remain unexplored. The main objective of this study was to identify the reactive metabolites of LIM using liquid chromatography-mass spectrometry. Three nucleophiles, glutathione (GSH), N-acetyl cysteine (NAC), and N-acetyl lysine (NAL), were used to trap the reactive metabolites of LIM in in vitro an

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Malik, Meenakshi, Abhijit Ganguli, and Moushumi Ghosh. "Enhancement of bioconversion efficiency of limonin byPseudmonas putidaG7." International Journal of Food Sciences and Nutrition 63, no. 1 (2011): 59–65. http://dx.doi.org/10.3109/09637486.2011.596823.

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Zhou, Xianke, Xue Hong, Dier Li, Menghua Zhong, and Haiyan Fu. "Limonin Protects Against AKI by Targeting ERK Signaling." Journal of the American Society of Nephrology 32, no. 10S (2021): 152–53. http://dx.doi.org/10.1681/asn.20213210s1152d.

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Wang, Shaochi, Xueqing Han, Yun Yang, et al. "A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception." RSC Medicinal Chemistry 11, no. 7 (2020): 843–47. http://dx.doi.org/10.1039/d0md00117a.

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Liu, Qi Zhi, He Qin Li, and Zhi Long Liu. "Nematocidal Constituents from the Ethanol Extract ofEvodia rutaecarpaHort Unripe Fruits." Journal of Chemistry 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/939215.

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The ethanol extract of Chinese medicinal herb,Evodia rutaecarpaHort unripe fruits, was found to possess nematocidal activity against the root-knot nematodes,Meloidogyne incognita, during the screening program for new agrochemicals from local wild plants and Chinese medicinal herbs. Bioactivity-guided chromatographic separation of the ethanol extract ofE. rutaecarpaon repeated silica gel columns led to isolate five constituent components (two limonoids, evodol and limonin; three alkaloids, evodiamine, rutaecarpine, and wuchuyuamide I). Evodiamine (LC50=73.55 μg/mL) and rutaecarpine (LC50=120.85

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Ramos-Ibarra, J. R., E. Arriola-Guevara, G. Toriz, G. M. Guatemala-Morales, and R. I. Corona-González. "Enzymatic extraction of limonene, limonin and other relevant compounds from Citrus sinensis (orange) and Citrus aurantiifolia (lime) by-products." Revista Mexicana de Ingeniería Química 20, no. 3 (2021): 1–11. http://dx.doi.org/10.24275/rmiq/bio2404.

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Breksa, Andrew P., and Klaus Dragull. "Development and validation of a decigram-scale method for the separation of limonin from limonin glucoside by C-18 flash chromatography." Food Chemistry 113, no. 4 (2009): 1308–13. http://dx.doi.org/10.1016/j.foodchem.2008.08.046.

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Sahu, Rajnish Kumar, Shashi Kiran Minj, and Pooja Sahu. "Thermosonication an Alternative to Thermal Pasteurization for Nagpur Mandarin Juice." International Journal of Plant & Soil Science 35, no. 18 (2023): 1181–90. http://dx.doi.org/10.9734/ijpss/2023/v35i183502.

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Nagpur mandarin is well known globally for its excellent nutritional benefits and flavour. These all characteristics get affected due to a lack of knowledge & processing techniques. Thermal pasteurization is a processing technique mostly used for juice processing before storage. Thermal pasteurization treatment leads to a loss in various physicochemical qualities of juice viz. ascorbic acid content, and carotenoid content. Thermal pasteurization treatment also leads to an increase in limonin content and the browning value of the juice. Therefore, an experiment was carried out to check the

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Cakrawati, D., and M. N. Handayani. "Microencapsulation of Limonin From Orange Juice Waste Using Maltodextrin." IOP Conference Series: Materials Science and Engineering 180 (March 2017): 012096. http://dx.doi.org/10.1088/1757-899x/180/1/012096.

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Mayank and Yogesh Kumar. "Limonin as serotonin mimetic to protect from Alzheimer’s disease." Journal of Phytopharmacology 13, no. 5 (2024): 359–60. https://doi.org/10.31254/phyto.2024.13503.

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Limonin (LM), a limonoid glycoside isolated from leaves, fruits, and seeds of citrus plants, belongs to the class of furanolactones [1]. Recently, LM has gained significant interest due to its multiple biological activities such as anti-inflammatory, antitumor, antimicrobial, and antifeedant activity. Lu et al. [2] demonstrated that pretreatment of LPS-induced microglial cells with LM substantially prohibited the formation of ROS and prevented the deposition of NO, PGE2, IL-1β, IL-6, and TNF-α [2]. Furthermore, LM significantly reduced the expressions of iNOS and COX-2 [3]. Their results indic

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Herman, Z. "Limonin biosynthesis from obacunone via obacunoate in Citrus limon." Phytochemistry 23, no. 12 (1985): 2911–13. http://dx.doi.org/10.1016/s0031-9422(00)80603-2.

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