Journal articles: 'Lindsay family'

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McMahon, Theo, Phyllis Lindsay Hiller, and Helen Fair Bennett. "Fair, Lindsay and Lundy Family History." Clogher Record 12, no. 1 (1985): 134. http://dx.doi.org/10.2307/27699219.

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Devitt, Patric. "The Child and Family B Lindsay , editor Bailliere Tindall 218pp > £10.95 0-7020-1646-2." Nursing Standard 8, no. 40 (June 29, 1994): 56. http://dx.doi.org/10.7748/ns.8.40.56.s67.

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McArver, Susan Wilds. "Maria Martin's World: Art & Science, Faith & Family in Audubon's America by Debra J. Lindsay." Lutheran Quarterly 34, no. 1 (2020): 96–97. http://dx.doi.org/10.1353/lut.2020.0020.

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Nobles, Gregory. "Maria Martin's World: Art and Science, Faith and Family in Audubon's America by Debra J. Lindsay." Journal of Southern History 85, no. 1 (2019): 155–56. http://dx.doi.org/10.1353/soh.2019.0017.

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Burningham, Kate. "Book Review: Jo Lindsay and JaneMaree Maher, Consuming Families: Buying, Making, Producing Family Life in the 21st Century." Sociology 50, no. 4 (June 4, 2015): 828–29. http://dx.doi.org/10.1177/0038038515586140.

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Devitt, Patric. "The Child and Family: Contemporary Nursing Issues Lindsay Bruce Editor The Child and Family: Contemporary Nursing Issues Bailliere Tindall 218pp £10.95 0-7020-1646-2." Paediatric Nursing 6, no. 5 (June 1994): 23. http://dx.doi.org/10.7748/paed.6.5.23.s21.

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Wyte-Lake, Tamar, and Leah Haverhals. "THE ROLE OF CAREGIVERS DURING DISASTERS." Innovation in Aging 6, Supplement_1 (November 1, 2022): 158. http://dx.doi.org/10.1093/geroni/igac059.629.

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Abstract The COVID-19 pandemic laid bare the critical role caregivers play in supporting the older adult population, and how easily care structures can fall apart under the stress of a disaster event. As our population rapidly ages, it is imperative to better understand how to support caregivers to ensure relationships between caregivers and older adults remain robust and guarantee everyone’s safety. Therefore, this symposium focuses on the roles of formal and informal caregivers during disasters, primarily the COVID-19 pandemic. Dr. Richard Chunga will present findings from a survey of homecare aides, exploring drivers of high turnover rates and describing how employers can improve job satisfaction. Dr. Lindsay Peterson will describe barriers and facilitators to disaster preparedness among caregivers, using interviews with caregivers from diverse backgrounds in Florida. Ms. Jessica McLaughlin (PhDc) will share experiences of informal female caregivers, derived from interviews across the United States (US). Chelsea Manheim (LCSW) will describe adaptations to care provision for rural Medical Foster Home (MFH) Veterans from interviews conducted with MFH care providers from across the US. Dr. Carrie Wendel-Hummell will share data around the strengths and challenges of the self-directed care model for home-based long-term care, drawing on interviews with consumers, caregivers, workers, and providers in Kansas. As a whole, these presenters will provide insights into experiences of caregivers as they navigated challenges associated with the COVID-19 pandemic and generate forward thinking on how to inform future disaster response. Sponsoring SIGs: Paid Caregiving, Family Caregiving, Assisted Living, Disaster and Older Adults

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. "Lindaan uit de handel." Huisarts en Wetenschap 51, no. 11 (November 2008): 522. http://dx.doi.org/10.1007/bf03086923.

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Hassan, Amal S., and Said G. Nassr. "Power Lindley-G Family of Distributions." Annals of Data Science 6, no. 2 (March 16, 2018): 189–210. http://dx.doi.org/10.1007/s40745-018-0159-y.

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Zink, T. "Response to Dr. S. Lindsey Clarke." Journal of the American Board of Family Medicine 20, no. 1 (January 1, 2007): 97–98. http://dx.doi.org/10.3122/jabfm.2007.01.060173.

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Mayekar, Manasi, Deborah Caswell, Natalie Vokes, Emily K. Law, Wei Wu, William Hill, Eva Gronroos, et al. "Abstract 2197: Targeted cancer therapy induces APOBEC fueling the evolution of drug resistance." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2197. http://dx.doi.org/10.1158/1538-7445.am2022-2197.

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Abstract Introduction: Increasing our understanding of drivers of mutagenesis in lung cancer is critical in our efforts to prevent tumor reoccurrence and resistance. Results: Using the multi-region TRACERx lung cancer study, we uncovered that APOBEC3B is significantly upregulated when compared with other APOBEC family members in EGFR driven lung cancer and identified subclonal enrichment of APOBEC mutational signatures. To model APOBEC mutagenesis in lung cancer, several novel EGFR mutant mouse models containing a human APOBEC3B transgene were generated. Using these models, it was uncovered that APOBEC3B expression is detrimental at tumor initiation when expressed continuously in a p53 wildtype background. This detrimental effect is likely due to elevated chromosomal instability, which was observed to increase significantly with APOBEC3B expression in an EGFR mutant TP53 deficient mouse model. Induction of subclonal expression of APOBEC3B in an EGFR mutant mouse model with tyrosine kinase inhibitor (TKI) therapy resulted in a significant increase in resistant tumor development. Significant downregulation of the base excision repair gene uracil-DNA glycosylase (UNG) was also observed in APOBEC3B expressing mice, which paralleled findings in patient tumors and cell lines treated with TKI therapy. Finally, a mouse mutational signature was identified in APOBEC3B expressing cell lines, reinforcing the idea that APOBEC driven mutagenesis contributes to TKI resistance. Conclusion: This study demonstrates a unique principle by which targeted therapy induces changes within tumors ideal for APOBEC driven tumor evolution, fueling therapy resistance. Citation Format: Manasi Mayekar, Deborah Caswell, Natalie Vokes, Emily K. Law, Wei Wu, William Hill, Eva Gronroos, Andrew Rowan, Maise Al Bakir, Clare Weeden, Caroline E. McCoach, Collin M. Blakely, Nuri Alpay Temiz, Ai Nagano, Daniel L. Kerr, Julia K. Rotow, Oriol Pich, Franziska Haderk, Michelle Dietzen, Carlos Martinez Ruiz, Bruna Almeida, Lauren Cech, Beatrice Gini, Joanna Przewrocka, Chris Moore, Miguel Murillo, Bjorn Bakker, Brandon Rule, Cameron Durfee, Shigeki Nanj, Lisa Tan, Lindsay K. Larson, Prokopios P. Argyris, William L. Brown, Johnny Yu, Carlos Gomez, Philippe Gui, Rachel I. Vogel, Elizabeth A. Yu, Nicholas J. Thomas, Subramanian Venkatesan, Sebastijan Hobor, Su Kit Chew, Nicholas McGranahan, Nnennaya Kanu, Eliezer M. Van Allen, Julian Downward, Reuben S. Harris, Trever Bivona, Charles Swanton. Targeted cancer therapy induces APOBEC fueling the evolution of drug resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2197.

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Marthin, Pius, and Gadde Srinivasa Rao. "Generalized Weibull–Lindley (GWL) Distribution in Modeling Lifetime Data." Journal of Mathematics 2020 (August 31, 2020): 1–15. http://dx.doi.org/10.1155/2020/2049501.

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In this manuscript, we have derived a new lifetime distribution named generalized Weibull–Lindley (GWL) distribution based on the T-X family of distribution specifically the generalized Weibull-X family of distribution. We derived and investigated the shapes of its probability density function (pdf), hazard rate function, and survival function. Some statistical properties such as quantile function, mode, median, order statistics, Shannon entropy, Galton skewness, and Moors kurtosis have been derived. Parameter estimation was done through maximum likelihood estimation (MLE) method. Monte Carlo simulation was conducted to check the performance of the parameter estimates. For the inference purpose, two real-life datasets were applied and generalized Weibull–Lindley (GWL) distribution appeared to be superior over its competitors including Lindley distribution, Akash distribution, new Weibull-F distribution, Weibull–Lindley (WL) distribution, and two-parameter Lindley (TPL) distribution.

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Alkarni, Said H. "GENERALIZED LINDLEY POWER SERIES FAMILY OF DISTRIBUTIONS." Advances and Applications in Statistics 53, no. 5 (November 17, 2018): 537–67. http://dx.doi.org/10.17654/as053050537.

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Gomes-Silva, Frank S., Ana Percontini, Edleide de Brito, Manoel W. Ramos, Ronaldo Venâncio, and Gauss Moutinho Cordeiro. "The Odd Lindley-G Family of Distributions." Austrian Journal of Statistics 46, no. 1 (January 4, 2017): 65–87. http://dx.doi.org/10.17713/ajs.v46i1.222.

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We propose a new generator of continuous distributions with one extra positive parameter called the odd Lindley-G family. Some special cases are presented. The new density function can be expressed as a linear combination of exponentiated densities based on the same baseline distribution. Various structural properties of the new family, which hold for any baseline model, are derived including explicit expressions for the quantile function, ordinary and incomplete moments, generating function, Renyi entropy, reliability, order statistics and their moments and k upper record values. We discuss estimation of the model parameters by maximum likelihood and provide an application to a real data set.

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Hassan, A., A. Rashid, and N. Akhtar. "Correction* Exponentiated quasi power Lindley power series distribution with applications in medical science." Journal of Applied Mathematics, Statistics and Informatics 16, no. 2 (December 1, 2020): 85–108. http://dx.doi.org/10.2478/jamsi-2020-0011.

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Abstract The present paper introduces an advanced five parameter lifetime model which is obtained by compounding exponentiated quasi power Lindley distribution with power series family of distributions. The EQPLPS family of distributions contains several lifetime sub-classes such as quasi power Lindley power series, power Lindley power series, quasi Lindley power series and Lindley power series. The proposed distribution exhibits decreasing, increasing and bathtub shaped hazard rate functions depending on its parameters. It is more flexible as it can generate new lifetime distributions as well as some existing distributions. Various statistical properties including closed form expressions for density function, cumulative function, limiting behaviour, moment generating function and moments of order statistics are brought forefront. The capability of the quantile measures in terms of Lambert W function is also discussed. Ultimately, the potentiality and the flexibility of the new class of distributions has been demonstrated by taking three real life data sets by comparing its sub-models.

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Hassan, A., A. Rashid, and N. Akhtar. "Exponentiated quasi power Lindley power series distribution with applications in medical science." Journal of Applied Mathematics, Statistics and Informatics 16, no. 1 (May 1, 2020): 37–60. http://dx.doi.org/10.2478/jamsi-2020-0004.

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AbstractThe present paper introduces an advanced five parameter lifetime model which is obtained by compounding exponentiated quasi power Lindley distribution with power series family of distributions. The EQPLPS family of distributions contains several lifetime sub-classes such as quasi power Lindley power series, power Lindley power series, quasi Lindley power series and Lindley power series. The proposed distribution exhibits decreasing, increasing and bathtub shaped hazard rate functions depending on its parameters. It is more flexible as it can generate new lifetime distributions as well as some existing distributions. Various statistical properties including closed form expressions for density function, cumulative function, limiting behaviour, moment generating function and moments of order statistics are brought forefront. The capability of the quantile measures in terms of Lambert W function is also discussed. Ultimately, the potentiality and the flexibility of the new class of distributions has been demonstrated by taking three real life data sets by comparing its sub-models.

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Cakmakyapan, Selen, and Gamze Ozel. "The Lindley Family of Distributions: Properties and Applications." Hacettepe Journal of Mathematics and Statistics 46, no. 116 (February 10, 2016): 1. http://dx.doi.org/10.15672/hjms.201611615850.

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Tomy, Lishamol, Veena G, and Christophe Chesneau. "The Sine Modified Lindley Distribution." Mathematical and Computational Applications 26, no. 4 (December 16, 2021): 81. http://dx.doi.org/10.3390/mca26040081.

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The paper contributes majorly in the development of a flexible trigonometric extension of the well-known modified Lindley distribution. More precisely, we use features from the sine generalized family of distributions to create an original one-parameter survival distribution, called the sine modified Lindley distribution. As the main motivational fact, it provides an attractive alternative to the Lindley and modified Lindley distributions; it may be better able to model lifetime phenomena presenting data of leptokurtic nature. In the first part of the paper, we introduce it conceptually and discuss its key characteristics, such as functional, reliability, and moment analysis. Then, an applied study is conducted. The usefulness, applicability, and agility of the sine modified Lindley distribution are illustrated through a detailed study using simulation. Two real data sets from the engineering and climate sectors are analyzed. As a result, the sine modified Lindley model is proven to have a superior match to important models, such as the Lindley, modified Lindley, sine exponential, and sine Lindley models, based on goodness-of-fit criteria of importance.

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Lee, Olivia W., Danielle M. Karyadi, Chip Stewart, Tetiana I. Bogdanova, Jieqiong Dai, Stephen W. Hartley, Sara J. Schonfeld, et al. "Abstract 980: Genomic characterization of lymph node metastases in papillary thyroid carcinoma following the Chernobyl accident reveals an expression profile specific to metastatic process." Cancer Research 82, no. 12_Supplement (June 15, 2022): 980. http://dx.doi.org/10.1158/1538-7445.am2022-980.

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Abstract Following the Chernobyl nuclear power plant explosion in Ukraine in 1986, increased childhood exposure to radioactive iodine (131I), which occurred primarily through contaminated food sources, has been consistently associated with increased risk of developing papillary thyroid carcinoma (PTC). Increased frequency of cervical lymph node metastases (LNM) is well recognized in pediatric PTC, including pediatric cases following the Chernobyl accident. We recently leveraged the collection of fresh-frozen tumor tissues from the Chernobyl Tissue Bank to conduct a genomic landscape analysis of 440 cases of PTC that provided new insights into radiation-related molecular characteristics of PTC occurring after the accident (Morton et al., Science 2021). Here, we extend that study to conduct a genomic landscape analysis of LNMs for a subset of 48 PTC cases to investigate the specific genomic alterations occurring in LNM. The analysis set comprised 144 samples, including fresh-frozen treatment-naïve primary and LNM PTC tumor samples as well as matched normal tissue or blood. Overall, the mutational load was highly concordant between primary and metastatic PTC. On average, 50% of somatic single nucleotide variants and 97% structural variants were shared between primary and metastatic PTCs. In contrast, the burden of somatic copy number alterations (SCNA) between primary tumor and LNM pairs was less concordant, particularly for copy number gains, whereas most of the copy number loss was found to be shared between matched pairs. PTC is usually driven by one driver mutation, most often involving the mitogen-activated protein kinase (MAPK) pathway. All driver mutations were shared between primary and metastatic PTC and were clonal; thus, no additional driver mutations were detected in metastatic PTC. Notably, however, the matched pairs in this study disproportionately had fusion drivers (77%), whereas only 23% of the drivers were BRAF V600E and none were RAS mutations. Transcriptome analysis revealed differentially expressed genes (DEGs) in metastatic PTC compared to primary PTC; three-quarters of the DEGs were overexpressed in metastatic PTC. Half of the LNM overexpressed DEGs were members of the HOXC family, which has been linked with epithelial-mesenchymal transition in cancer progression. There was also reduced expression in LNM for the DLX family, which relates to TGF-beta signaling. Our findings did not reveal a relationship between radiation dose and expression profiles in the LNM, comparable to our findings for the primary PTCs. We still observe that the efficiency of the radiation-induced PTC is paramount and subsequent events are directly related to the drivers in the MAPK pathway. For the cervical LNMs, we observed expression profiles not observed in the primary PTC that could give new insights into PTC local metastases. Citation Format: Olivia W. Lee, Danielle M. Karyadi, Chip Stewart, Tetiana I. Bogdanova, Jieqiong Dai, Stephen W. Hartley, Sara J. Schonfeld, Vidushi Kapoor, Marko Krznaric, Meredith Yeager, Amy Hutchinson, Belynda D. Hicks, Casey L. Dagnall, Julie M. Gastier-Foster, Jay Bowen, Mitchell J. Machiela, Elizabeth K. Cahoon, Kiyohiko Mabuchi, Vladimir Drozdovitch, Sergii Masiuk, Mykola Chepurny, Liudmyla Y. Zurnadzhy, Amy Berrington de González, Gad Getz, Gerry A. Thomas, Mykola D. Tronko, Lindsay M. Morton, Stephen J. Chanock. Genomic characterization of lymph node metastases in papillary thyroid carcinoma following the Chernobyl accident reveals an expression profile specific to metastatic process [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 980.

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Chipepa, Fastel, Broderick Oludeye, and Boikanyo Makubate. "The New Odd Lindley-G Power Series Class of Distributions: Theory, Properties and Applications." Afrika Statistika 16, no. 3 (July 1, 2021): 2825–949. http://dx.doi.org/10.16929/as/2021.2819.186.

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We propose a new generalized class of distributions called the odd Lindley-G Power Series (OL-GPS) family of distributions and a special class, namely, odd Lindley-Weibull power series (OL-WPS) family of distributions. We also derive the structural properties of the OL-GPS family of distributions including moments, order statistics, Rényi entropy, mean and median deviations, Bonferroni and Lorenz curves, and maximum likelihood estimates. Sub-models of the special cases were also obtained together with their structural properties. A simulation study to examine the consistency of the maximum likelihood estimators for each parameter is presented. Finally, real data examples are presented to illustrate the applicability and usefulness of the proposed model

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Chipepa, Fastel, Broderick Oludeye, and Boikanyo Makubate. "The New Odd Lindley-G Power Series Class of Distributions: Theory, Properties and Applications." Afrika Statistika 16, no. 3 (July 1, 2021): 2825–949. http://dx.doi.org/10.16929/as/2021.2825.186.

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We propose a new generalized class of distributions called the odd Lindley-G Power Series (OL-GPS) family of distributions and a special class, namely, odd Lindley-Weibull power series (OL-WPS) family of distributions. We also derive the structural properties of the OL-GPS family of distributions including moments, order statistics, Rényi entropy, mean and median deviations, Bonferroni and Lorenz curves, and maximum likelihood estimates. Sub-models of the special cases were also obtained together with their structural properties. A simulation study to examine the consistency of the maximum likelihood estimators for each parameter is presented. Finally, real data examples are presented to illustrate the applicability and usefulness of the proposed model

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Arana, Marcelo Daniel. "Lectotypification of the name Regnellidium diphyllum (Marsileaceae)." Phytotaxa 221, no. 1 (July 28, 2015): 97. http://dx.doi.org/10.11646/phytotaxa.221.1.12.

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Regnellidium Lindman (1904: 2) is a genus that includes only the extant species Regnellidium diphyllum Lindman (1904: 14) in the family Marsileaceae Mirbel (1802: 126), which encompasses a total of three extant genera of aquatic, heterosporous ferns. While the other two genera within the family, Marsilea L. (1753: 1099) with 50–75 spp., and Pilularia L. (1753: 1100) with 3–6 spp., are nearly cosmopolitan in distribution, the extant species of Regnellidium is restricted to a small region of South America, found only in northeastern Argentina, southern Brazil, and Uruguay (Schultz, 1949; de la Sota & Mitchel 1970; Tryon & Tryon 1982; Kramer, 1990; Alonso Paz & Bassagoda, 2002; Cúneo et al., 2013). It was only in 1892, on the first Regnell expedition, that Lindman discovered the plants, which he described as Regnellidium (Lindman, 1904), on the banks of the Rio Grande do Sul, in southern Brazil. The species was not found again until November 1935, when it was located at Santa Maria by Dr. W. Rau and at São Leopoldo by Dr. J. Dutra (Johnson & Chrysler, 1938). Today it is widely cultivated in Botanic Gardens.

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Abd El-Bar, Ahmed, Willams da Silva, and Abraão Nascimento. "An Extended log-Lindley-G Family: Properties and Experiments in Repairable Data." Mathematics 9, no. 23 (December 2, 2021): 3108. http://dx.doi.org/10.3390/math9233108.

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In this article, two new families of distributions are proposed: the generalized log-Lindley-G (GLL-G) and its counterpart, the GLL*-G. These families can be justified by their relation to the log-Lindley model, an important assumption for describing social and economic phenomena. Specific GLL models are introduced and studied. We show that the GLL density is rewritten as a two-member linear combination of the exponentiated G-densities and that, consequently, many of its mathematical properties arise directly, such as moment-based expressions. A maximum likelihood estimation procedure for the GLL parameters is provided and the behavior of the resulting estimates is evaluated by Monte Carlo experiments. An application to repairable data is made. The results argue for the use of the exponential law as the basis for the GLL-G family.

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ODYUO, NRIPEMO, DILIP KUMAR ROY, AVISHEK BHATTACHARJEE, and PAUL ORMEROD. "Rhomboda monensis (Orchidaceae), a new species of terrestrial orchid from India." Phytotaxa 405, no. 1 (May 29, 2019): 61. http://dx.doi.org/10.11646/phytotaxa.405.1.6.

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The genus Rhomboda Lindley (1857: 181), belonging to the family Orchidaceae (Orchidoideae: Cranichideae: Goodyerinae), was first described by John Lindley with a single species, viz. R. longifolia Lindley (1857: 181). Bentham (1881: 346) reduced Rhomboda to Hetaeria Blume (1825: 409), but Hooker (1890: 109) transferred it to Zeuxine Lindley (1826: 9). Tang & Wang (1951: 34) included R. longifolia in Odontochilus Blume (1858: 66), overlooking the priority of Rhomboda over Odontochilus. Finally, Ormerod (1995) reinstated Rhomboda and reviewed its generic affinities, circumscription and clarified some of the confusions about the genus. Rhomboda is characterised by a labellum with large, saccate hypochile having two glands within (one at either side), medially with a bicarinate, semidiscoid keel, hypochile outside with a narrow flange each side, the column with two large medial wings, and a short rostellum.

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Abouammoh, Abdulrahman, and Mohamed Kayid. "A New Family of Extended Lindley Models: Properties, Estimation and Applications." Mathematics 8, no. 12 (December 2, 2020): 2146. http://dx.doi.org/10.3390/math8122146.

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There are many proposed life models in the literature, based on Lindley distribution. In this paper, a unified approach is used to derive a general form for these life models. The present generalization greatly simplifies the derivation of new life distributions and significantly increases the number of lifetime models available for testing and fitting life data sets for biological, engineering, and other fields of life. Several distributions based on the disparity of the underlying weights of Lindley are shown to be special cases of these forms. Some basic statistical properties and reliability functions are derived for the general forms. In addition, comparisons among various forms are investigated. Moreover, the power distribution of this generalization has also been considered. Maximum likelihood estimator for complete and right-censored data has been discussed and in simulation studies, the efficiency and behavior of it have been investigated. Finally, the proposed models have been fit to some data sets.

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Shanker, Rama, and Umme Habibah Rahman. "A New Two-Parameter Lindley Distribution." Nepal Journal of Mathematical Sciences 1 (October 31, 2020): 33–42. http://dx.doi.org/10.3126/njmathsci.v1i0.34157.

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In this paper, a new two-parameter Lindley distribution has been proposed. Descriptive statistical properties along with order statistics, Fisher information matrix and confidence interval of the proposed distribution have been discussed. Parameters are estimated by the method of Maximum Likelihood estimation. A real lifetime data has been presented to test the goodness of fit of the proposed distribution over other one parameter and two –parameter Lindley family of distributions.

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Shanker, Rama, and Umme Habibah Rahman. "A New Two-Parameter Lindley Distribution." Nepal Journal of Mathematical Sciences 1 (October 31, 2020): 33–42. http://dx.doi.org/10.3126/njmathsci.v1i0.34157.

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In this paper, a new two-parameter Lindley distribution has been proposed. Descriptive statistical properties along with order statistics, Fisher information matrix and confidence interval of the proposed distribution have been discussed. Parameters are estimated by the method of Maximum Likelihood estimation. A real lifetime data has been presented to test the goodness of fit of the proposed distribution over other one parameter and two –parameter Lindley family of distributions.

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Romo-Mayor, Paula. "Violence, Vulnerability and the Overcoming of Trauma in Rachel Seiffert’s The Walk Home." Estudios Irlandeses, no. 17 (March 17, 2022): 115–29. http://dx.doi.org/10.24162/ei2022-10678.

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Rachel Seiffert’s The Walk Home (2014) tells the story of a Protestant Irish family living in Glasgow that has been haunted by a problematic fanaticism since the Partition of Ireland (1922). Its narrative builds an intricate family tree where its members, immersed in the vicious cycle of ethno-sectarian violence, reveal their own traumas and intrinsic frailties. Their isolation and helplessness are further exacerbated by their tendency to repress their traumatic past. However, the encounter between Lindsey and Eric, two relatives-in-law, encourages them to run away and confront the past through art respectively, thus casting some light on the unending transmission of trauma in the family. Drawing on theories of trauma and ethics (Freud 1950 [1917], 2001 [1914]; Levinas 1986, 1998 [1993]; Volkan 2001, 2017; Butler 2004; LaCapra 2014 [2001]), I will attempt to demonstrate, firstly, that the narrative form of The Walk Home performs the disruptive and repetitive symptoms of transgenerational trauma; and secondly, that the ethical encounter with the other and the recognition of a shared vulnerability transmitted through families can empower characters like Lindsey and Eric to change their lives. The analysis also considers the possibility of challenging the perpetuity of the traumas arising out of the British-Irish conflict and developing resilience through the acknowledgement of vulnerability, the need for interdependency and the heling power of artistic representation.

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Bentham, Robert, David A. Moore, Lorelle Brownlee, Raju Veeriah, Lizi Manzano, Fiona Blackhall, Colin R. Lindsay, Nicholas McGranahan, Charles Swanton, and Mariam Jamal-Hanjani. "Abstract 6080: The heterogeneity and evolution of lung neuroendocrine tumors within TRACERx." Cancer Research 82, no. 12_Supplement (June 15, 2022): 6080. http://dx.doi.org/10.1158/1538-7445.am2022-6080.

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Abstract Introduction: Primary pulmonary neuroendocrine tumors (NETs) contribute to 20-25% of all lung cancer diagnoses and lie on a spectrum of malignant behavior, ranging from low grade classical carcinoid tumors to high grade, aggressive small cell carcinomas. The evolutionary relationships between NETs of different grades remain poorly understood, here we seek to use the TRACERx study to explore the genomic evolution of these lung cancers. Methods: Tissue and blood samples were taken from a cohort of 20 patients with pulmonary NETs in a sub-study within TRACERx. Multi-region sampling (84 total regions) and whole exome sequencing was performed on fresh frozen tissue from each tumor. Histological classification of each tumor region was confirmed and scoring of tumor infiltrating lymphocytes (TILs) was performed. The data were then analyzed using the established TRACERx bioinformatics pipeline. Results: Phylogenetic evolutionary histories were generated, illustrating the genomic divergence in each tumor and identifying points at which specific known drivers were acquired during tumor evolution. Lower grade classical and atypical carcinoids were characterized by a low mutational and copy number burden with a high fraction of subclonal mutations, with 5/12 cases having no apparent somatic mutational driver mutation. In contrast higher grade large cell neuroendocrine carcinomas and small cell carcinomas had higher mutational and copy number burden, as well as higher rates of genome instability and whole genome doubling. We identified no evolutionary link between subtypes such as commonly shared clonal drivers, suggesting that atypical or classical carcinoids later evolve into higher grade carcinomas. Dn/ds was used to investigate for evidence of selection in the carcinoid tumors; while there was no evidence for selection in known cancer driver genes associated with NETs or lung cancer, there was a high global dn/ds value suggesting the existence of unknown drivers for this cancer type. Furthermore, there was evidence of parallel evolution in one atypical carcinoid case with two distinct subclonal MEN1 frameshift mutations co-occurring with loss of the other allele. One small cell carcinoma patient was identified as having two genetically unrelated tumors. A germline predisposition for this tumor was suspected since we identified a variant in BRCA2 (rs11571833) that was maintained under loss of heterozygosity in one tumor with a corresponding somatic BRCA2 mutation in the other, suggesting two independent double hit events. Conclusions: Genomic differences are identifiable between different members of the pulmonary NET family, with high grade tumors showing increased whole genome instability indices and phylogenetic divergence than low grade tumors. This work has shed light on the genomic landscape of pulmonary NETs and enabled the identification of distinct evolutionary trajectories in the different subtypes. Citation Format: Robert Bentham, David A. Moore, Lorelle Brownlee, Raju Veeriah, Lizi Manzano, Fiona Blackhall, Colin R. Lindsay, TRACERx Consortium, Nicholas McGranahan, Charles Swanton, Mariam Jamal-Hanjani. The heterogeneity and evolution of lung neuroendocrine tumors within TRACERx [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6080.

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Unyime, Patrick Udoudo, and Ette Harrison Etuk. "A New Extension of Quasi Lindley Distribution: Properties and Applications." International Journal of Advanced Statistics and Probability 7, no. 2 (October 24, 2019): 28. http://dx.doi.org/10.14419/ijasp.v7i2.29791.

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In this paper, we introduced and studied the statistical properties of a new distribution called the Marshall-Olkin extended quasi Lindley distribution. Specifically, we derived the crude moment, moment generating function, quantile function, and distributions of order statisticsbased on the distribution. The maximum likelihood point estimation method was used to estimate the parameters of the newly introduced model. Some AR minfication processes were discussed. We illustrated the applicability of the distribution using a real dataset.Keywords: Marshal-Olkin family of distributions; maximum likelihood estimates; minification processes; quasi Lindley distribution; quantile function.

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Chipepa, Fastel, Broderick O. Oluyede, and Boikanyo Makubate. "A New Generalized Family of Odd Lindley-G Distributions With Application." International Journal of Statistics and Probability 8, no. 6 (September 25, 2019): 1. http://dx.doi.org/10.5539/ijsp.v8n6p1.

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A new family of distributions, namely the Kumaraswamy Odd Lindley-G distribution is developed. The new density function can be expressed as a linear combination of exponentiated-G densities. Statistical properties of the new family including hazard rate and quantile functions, moments and incomplete moments, Bonferroni and Lorenz curves, distribution of order statistics and R´enyi entropy are derived. Some special cases are presented. We conduct some Monte Carlo simulations to examine the consistency of the maximum likelihood estimates. We provide an application of KOL-LLo distribution to a real data set.

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Konishi, Eiichi, Yasuaki Nakashima, Thomas C. Smyrk, and Seiji Masuda. "Clear Cell Carcinoid Tumor of the Gallbladder." Archives of Pathology & Laboratory Medicine 127, no. 6 (June 1, 2003): 745–47. http://dx.doi.org/10.5858/2003-127-745-ccctot.

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Abstract A golden yellow polyp was detected in the gallbladder of a 64-year-old man who presented with epigastric pain. The lesion was composed of clear polygonal cells arranged in a trabecular and glandular pattern. The tumor invaded through the wall into the perimuscular subserosal layer. Immunohistochemical stains showed that neoplastic cells were positive for chromogranin A, synaptophysin, somatostatin, gastrin, and pancreatic polypeptide and negative for glucagon, serotonin, insulin, S100 protein, and inhibin. This tumor resembles the recently described clear cell endocrine tumors of the gallbladder and pancreas that are associated with von Hippel-Lindau disease. Our patient, however, had neither personal nor family history indicative of von Hippel-Lindau disease. Furthermore, published accounts of clear cell endocrine tumors in von Hippel-Lindau disease describe immunoreactivity for inhibin; the current case was negative for the disease. There may be a subtype of clear cell carcinoid tumor not associated with von Hippel-Lindau disease, which is characterized by its lack of immunoreactivity against inhibin.

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Telee, Lal Babu Sah, and Vijay Kumar. "Lindley Generalized Inverted Exponential Distribution: Model and Applications." Pravaha 27, no. 1 (December 31, 2021): 61–72. http://dx.doi.org/10.3126/pravaha.v27i1.50616.

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In this article, we have proposed three parameters distribution using lindley family of distribution and Generalized inverted Exponential distribution called Lindley Generalized Inverted Exponential Distribution: Model and Applications(LGIE). The statistical properties as well as different characteristics like the hazard rate function (HRF), the probability density function (PDF), the cumulative distribution function (CDF), quantile function , skewness, and kurtosis of the proposed distribution are discussed. The parameters of the proposed distribution are estimated by using the maximum likelihood estimation (MLE), least-square estimation (LSE) and Cramer-Von-Mises (CVM) methods. All the computations are performed in R programming software. To assess the application of the proposed distribution, a real lifetime data set is analyzed and performed the goodness-of-fit.

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JUDSON, MARK L. I. "First fossil record of the pseudoscorpion family Pseudochiridiidae (Arachnida, Chelonethi, Cheiridioidea) from Dominican amber." Zootaxa 1393, no. 1 (January 18, 2007): 45–51. http://dx.doi.org/10.11646/zootaxa.1393.1.5.

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Pseudochiridium lindae n. sp. is described from Dominican amber (Miocene), representing the first fossil record of the family Pseudochiridiidae. The extant species Pseudochiridium insulae Hoff, 1964 is newly recorded from the Dominican Republic. Paracheiridium vachoni Vitali-di Castri, 1970 is transferred to the genus Pseudochiridium With, 1906 (n. comb.). The correct publication date for family-group names based on Cheiridiinae Hansen is shown to be 1894.

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JUDSON, MARK L. I. "First fossil record of the pseudoscorpion family Pseudochiridiidae (Arachnida, Chelonethi, Cheiridioidea) from Dominican amber." Zootaxa 1393, no. 1 (January 18, 2007): 45. http://dx.doi.org/10.11646/zootaxa.1393.5.

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Pseudochiridium lindae n. sp. is described from Dominican amber (Miocene), representing the first fossil record of the family Pseudochiridiidae. The extant species Pseudochiridium insulae Hoff, 1964 is newly recorded from the Dominican Republic. Paracheiridium vachoni Vitali-di Castri, 1970 is transferred to the genus Pseudochiridium With, 1906 (n. comb.). The correct publication date for family-group names based on Cheiridiinae Hansen is shown to be 1894.

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Korkmaz, Mustafa C., Haitham M. Yousof, and G. G. Hamedani. "The Exponential Lindley Odd Log-Logistic-G Family: Properties, Characterizations and Applications." Journal of Statistical Theory and Applications 17, no. 3 (2018): 554. http://dx.doi.org/10.2991/jsta.2018.17.3.10.

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Sengweni, Whatmore, Brodrick Oluyede, and Boikanyo Makubate. "The exponentiated half-logistic odd lindley-G family of distributions with applications." Journal of Nonlinear Sciences and Applications 14, no. 05 (January 18, 2021): 287–309. http://dx.doi.org/10.22436/jnsa.014.05.01.

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Reyad, Hesham, Morad Alizadeh, Farrukh Jamal, and Soha Othman. "The Topp Leone odd Lindley-G family of distributions : Properties and applications." Journal of Statistics and Management Systems 21, no. 7 (October 2018): 1273–97. http://dx.doi.org/10.1080/09720510.2018.1495157.

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Korkmaz, Mustafa C., Emrah Altun, Haitham M. Yousof, and G. G. Hamedani. "The Odd Power Lindley Generator of Probability Distributions: Properties, Characterizations and Regression Modeling." International Journal of Statistics and Probability 8, no. 2 (January 25, 2019): 70. http://dx.doi.org/10.5539/ijsp.v8n2p70.

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In this study, a new flexible family of distributions is proposed with its statistical properties as well as some useful characterizations. The maximum likelihood method is used to estimate the unknown model parameters by means of two simulation studies. A new regression model is proposed based on a special member of the proposed family called, the log odd power Lindley Weibull distribution. Residual analysis is conducted to evaluate the model assumptions. Four applications to real data sets are given to demonstrate the usefulness of the proposed model.

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Islam Khan, Md Awwal, Amirah Saeed Alharthi, Hassan M. Aljohani, Taghreed M. Jawa, Neveen Sayed-Ahmed, Md Shohel Rana, and Md Mahabubur Rahman. "Classical Inference of the Cubic Transmuted Lindley Distribution under Type-II Censored Sample." Mathematical Problems in Engineering 2022 (May 17, 2022): 1–16. http://dx.doi.org/10.1155/2022/3543517.

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Statistician always tries to find an easy method that gives a suitable fit. However, proposing a new distribution always solves many statistical problems. In this paper, we introduce a new extension of the Lindley distribution. We made a statistical inference under complete and Type-II censored sample on a new extension of the Lindley distribution. We have deduced its PDF and CDF using a cubic transmuted family that is because the new equations are very easy in computation. We called the new form the cubic transmuted Lindley distribution. The probability distribution function and the cumulative distribution function were also written as a closed form along with some mathematical properties. The classical method, which is the maximum likelihood estimation technique and maximum product of spacing technique, was used to find the estimators of the unknown model parameters. At last, to prove the superiority and applicability of the model, three real data sets are implemented and compared using the proposed method. We made a comparison with some of its baseline distributions and some other extensions, and our model outperforms the published ones.

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Hassan, Amal, Salwa Assar, and Kareem Ali. "The complementary Poisson-Lindley class of distributions." International Journal of Advanced Statistics and Probability 3, no. 2 (June 29, 2015): 146. http://dx.doi.org/10.14419/ijasp.v3i2.4624.

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<p>This paper proposed a new general class of continuous lifetime distributions, which is a complementary to the Poisson-Lindley family proposed by Asgharzadeh et al. [3]. The new class is derived by compounding the maximum of a random number of independent and identically continuous distributed random variables, and Poisson-Lindley distribution. Several properties of the proposed class are discussed, including a formal proof of probability density, cumulative distribution, and reliability and hazard rate functions. The unknown parameters are estimated by the maximum likelihood method and the Fisher’s information matrix elements are determined. Some sub-models of this class are investigated and studied in some details. Finally, a real data set is analyzed to illustrate the performance of new distributions.</p>

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Refaie, Mohamed. "A New Family of Continuous Distributions: Properties, Copulas and Real Life Data Modeling." Statistics, Optimization & Information Computing 9, no. 3 (July 26, 2021): 748–68. http://dx.doi.org/10.19139/soic-2310-5070-1130.

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A new family of distributions called the Kumaraswamy Rayleigh family is defied and studied. Some of its relevant statistical properties are derived. Many new bivariate type G families using the of Farlie-Gumbel-Morgenstern, modified Farlie-Gumbel-Morgenstern copula, Clayton copula and Renyi’s entropy copula are derived. The method of the maximum likelihood estimation is used. Some special models based on log-logistic, exponential, Weibull, Rayleigh, Pareto type II and Burr type X, Lindley distributions are presented and studied. Three dimensional skewness and kurtosis plots are presented. A graphical assessment is performed. Two real life applications to illustrate the flexibility, potentiality and importance of the new family is proposed.

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Awodutire, Phillip Oluwatobi, Oluwafemi Samson Balogun, Akintayo Kehinde Olapade, and Ethelbert Chinaka Nduka. "The modified beta transmuted family of distributions with applications using the exponential distribution." PLOS ONE 16, no. 11 (November 18, 2021): e0258512. http://dx.doi.org/10.1371/journal.pone.0258512.

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In this work, a new family of distributions, which extends the Beta transmuted family, was obtained, called the Modified Beta Transmuted Family of distribution. This derived family has the Beta Family of Distribution and the Transmuted family of distribution as subfamilies. The Modified beta transmuted frechet, modified beta transmuted exponential, modified beta transmuted gompertz and modified beta transmuted lindley were obtained as special cases. The analytical expressions were studied for some statistical properties of the derived family of distribution which includes the moments, moments generating function and order statistics. The estimates of the parameters of the family were obtained using the maximum likelihood estimation method. Using the exponential distribution as a baseline for the family distribution, the resulting distribution (modified beta transmuted exponential distribution) was studied and its properties. The modified beta transmuted exponential distribution was applied to a real life time data to assess its flexibility in which the results shows a better fit when compared to some competitive models.

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Ariyarathne, Menaka, and Deepthi Yakandawala. "Notes on fairy orchids (Magnoliopsida: Asparagales: Orchidaceae: Oberonia) of Sri Lanka: revision in regional distribution and documentation on vegetative propagation." Journal of Threatened Taxa 10, no. 5 (April 26, 2018): 11683. http://dx.doi.org/10.11609/jott.3854.10.5.11683-11685.

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Genus Oberonia Lindley is one of the species rich genera in the family Orchidaceae. According to the latest literature found in Sri Lanka, there are 50 endemic species, including nine endemics belonging to the genus Oberonia among 184 species in the family Orchidaceae. On comparing it with global level information, a revision of statistics on regional level seems vital. This short communication discusses the required revision in regional distribution of the genus Oberonia while documenting the first observation of vegetative propagation of the genus Oberonia from Sri Lanka.

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Lindsay, Robert, H. Roger Grant, Marsha L. Frey, John T. Reilly, James F. Marran, Victoria L. Enders, Benjamin Tate, et al. "Book Reviews." Teaching History: A Journal of Methods 14, no. 1 (May 5, 1989): 36–56. http://dx.doi.org/10.33043/th.14.1.36-56.

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Martin K. Sorge. The Other Price of Hitler's War. German Military and Civilian Losses Resulting from World War II. Westport, CT: Greenwood Press, 1986. Pp. xx, 175. Cloth, $32.95; M. K. Dziewanowski. War At Any Price: World War II in Europe, 1939-1945. Englewood Cliffs, NJ: Prentice-Hall, 1987. Pp. xiv, 386. Paper, $25.67. Review by Lawrence S. Rines of Quincy Community College. David Goldfield. Promised Land: The South Since 1945. Arlington Heights, IL: Harlan Davidson, Inc., 1987. Pp. xiii, 262. Cloth, $19.95, Paper, $9.95; Alexander P. Lamis. The Two Party South. New York: Oxford University Press, 1984. Pp. x, 317. Cloth, $25.00; Paper, $8.95. Review by Ann W. Ellis of Kennesaw College. Walter J. Fraser, Jr., R. Frank Saunders, Jr., and Jon L. Wakelyn, eds. The Web of Southern Social Relations: Women, Family, and Education. Athens: University of Georgia Press, 1985. Pp. XVII, 257. Paper, $12.95. Review by Thomas F. Armstrong of Georgia College. William H. Pease and Jane H. Pease. The Web of Progress: Private Values and Public Styles in Boston and Charleston, 1828-1842. New York and Oxford: Oxford University Press, 1985. Pp. xiv, 334. Paper, $12.95. Review by Peter Gregg Slater of Mercy College. Stephen J. Lee. The European Dictatorships, 1918-1945. London and New York: Methuen, 1987. Pp. xv, 343. Cloth, $47.50; Paper, $15.95. Review by Brian Boland of Lockport Central High School, Lockport, IL. Todd Gitlin. The Sixties: Days of Hope, Days of Rage. New York: Bantam, 1987. Pp. 483. Cloth, $19.95; Maurice Isserman. IF I HAD A HAMMER... : The Death of the Old Left and the Birth of the New Left. New York: Basic Books, 1987. Pp. xx, 244. Cloth, $18.95. Review by Charles T. Banner-Haley of Martin Luther King, Jr. Center for Nonviolent Social Change, Inc. Donald Alexander Downs. Nazis in Skokie: Freedom, Community, and the First Amendment. Notre Dame IN: Notre Dame Press, 1985. Pp. 227. Paper, $9.95. Review by Benjamin Tate of Macon Junior College. Paul Preston, The Triumph of Democracy in Spain. London and New York: Methuen, 1986. Pp. 227. Cloth, $32.00. Review by Victoria L. Enders of Northern Arizona University. Robert B. Downs. Images of America: Travelers from Abroad in the New World. Urbana and Chicago: University of Illinois Press, 1987. Pp. 232. Cloth, $24.95. Review by James F. Marran of New Trier Township High School, Winnetka, IL. Joel H. Silbey. The Partisan Imperative: The Dynamics of American Politics Before the Civil War. New York and Oxford: Oxford University Press, 1985. Pp. viii, 234. Paper, $8.95. Review by John T. Reilly of Mount Saint Mary College. Barbara J. Howe, Dolores A. Fleming, Emory L. Kemp, and Ruth Ann Overbeck. Houses and Homes: Exploring Their History. Nashville: The American Association for State and Local History, 1987. Pp. xii, 168. Paper, $13.95; $11.95 to AASLH members. Review by Marsha L. Frey of Kansas State University. Thomas C. Cochran. Challenges to American Values: Society, Business and Religion. New York and Oxford: Oxford University Press, 1987. Pp. 147. Paper, $6.95. Review by H. Roger Grant of University of Akron. M.S. Anderson. Europe in the Eighteenth Century, 1713-1783. London and New York: Longman, 1987. Third Edition. Pp. xii, 539. Cloth, $34.95. Review by Robert Lindsay of the University of Montana.

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Thulung, Suraj, Ashish Baniya, Subodh Sharma Paudel, Anirudra Devkota, and Shikher Shrestha. "Von Hippel-Lindau Syndrome- A Case Report." Journal of Brain and Spine Foundation Nepal 1, no. 1 (October 16, 2020): 25–28. http://dx.doi.org/10.3126/jbsfn.v1i1.32227.

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Von Hippel–Lindau (VHL) disease is a rare, familial disorder involving multiple organs, and characterized by the development of many benign and malignant tumors. It is an autosomal dominant disorder with high penetrance and variable expression. We present a case of a 31-year-old gentleman with gradual onset painless bilateral diminution in the vision for one and a half months with significant positive family history. Radiographic study revealed multiple cerebellar hemangioblastomas with obstructive hydrocephalus, renal cortical and pancreatic cysts and cystic renal cell carcinoma. Symptoms were relieved after endoscopic third ventriculostomy. These constellations of findings suggested von Hippel Lindau (VHL) syndrome and we present this case.

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Neumann, Hartmut P. H., Hans R. Eggert, Klaus Weigel, Hartmut Friedburg, Otmar D. Wiestler, and Peter Schollmeyer. "Hemangioblastomas of the central nervous system." Journal of Neurosurgery 70, no. 1 (January 1989): 24–30. http://dx.doi.org/10.3171/jns.1989.70.1.0024.

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✓ The findings of a 10-year study (1976 to 1986) conducted in southwest Germany on hemangioblastomas (HBL's) of the central nervous system (CNS) are presented. During that period, 47 HBL's were diagnosed and surgically removed in 44 patients, with a good postoperative survival rate and prognosis. The majority (83%) of these tumors were located in the cerebellum. By thorough clinical examination of the patients and careful evaluation of their family background, it was found that 23% of the HBL patients were afflicted with von Hippel-Lindau syndrome. In addition to the CNS tumors, 14 neoplastic or similar lesions were detected in other tissues. These included angiomatosis of the retinae, pheochromocytomas, pancreatic cysts, renal cysts, and renal carcinoma. The diagnosis of von Hippel-Lindau syndrome was thus established in seven families. The authors suggest the need for a screening program for patients with HBL of the CNS which is designed to confirm or exclude ocular or visceral lesions associated with von Hippel-Lindau syndrome.

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Kanayama, Hiro-omi, Seiichi Naruo, Hiroshi Takigawa, Susumu Kagawa, Keiichi Kondo, Masahiro Yao, Taro Shuin, and Masahiko Hosaka. "MOLECULAR GENETIC ANALYSIS OF A FAMILY WITH VON HIPPEL-LINDAU DISEASE." Japanese Journal of Urology 86, no. 7 (1995): 1216–20. http://dx.doi.org/10.5980/jpnjurol1989.86.1216.

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Dodd, Lindsey. "Wartime Rupture and Reconfiguration in French Family Life: Experience and Legacy." History Workshop Journal 88 (2019): 134–52. http://dx.doi.org/10.1093/hwj/dbz025.

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Abstract ‘Wartime Rupture and Reconfiguration in French Family Life: Experience and Legacy’, by Lindsey Dodd Family separation is a widespread consequence of war, particularly war which targets civilian populations. This article draws on oral history narratives recorded by the author with French people who became child evacuees or refugees in France during the Second World War. All ended up in the département of the Creuse, in central France, hosted by people with whom they had no previous connection. Experiences of family rupture and reconfiguration have been considered by psychologists, but rarely by historians. As children live their lives mainly in the domestic sphere, close examination of their wartime worlds gives insight into the indirect effects of conflict on the youngest members of society. I argue that the experience of the Second World War must be understood as profound and lasting, even among those who did not experience combat, persecution or aggression directly. My case studies complicate understandings of family separation as a wholly negative experience for children in war, without compromising sensitivity to the nuances of individual difference. And I show the power of subjective retrospective sources to reveal the legacy of war inside commemorative actions situated well below national levels, which go unacknowledged in studies focused on the ‘collective’ or ‘cultural’ memory of the period.

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Larina, I. I., N. M. Platonova, E. A. Troshina, A. A. Roslyakova, D. G. Belzevich, L. S. Selivanova, M. Yu Ukina, et al. "VON HIPPEL-LINDAU SYNDROME: ASPECTS OF TREATMENT AND MANAGEMENT. CASE REPORT AND LITERATURE REVIEW." Russian Archives of Internal Medicine 9, no. 3 (May 28, 2019): 165–71. http://dx.doi.org/10.20514/2226-6704-2019-9-3-165-171.

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The steadily growing interest in studying of endocrine genetics is driven not only by the search for new pathologies but also by the most pressing need to develop methods for early diagnosis, treatment and management of patients. Though 20% of all the patients with von Hippel-Lindau syndrome do not have a family history of the disease; a genetic basis is a natural characteristic of the disease and determinates a phenotype. Despite the nonaggressive course, in general, a relative unpredictability of the syndrome signs onset and the lack of regular monitoring can increase the risk of surgery complications and cause a disability at a young age. The presented clinical case shows the need for a multidisciplinary approach to management of the patients with von Hippel-Lindau syndrome.

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Journal articles on the topic 'Lindsay family'

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