Dissertations / Theses: 'Line Profile Analysis'

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Thompson, Gregory Brandon. "Time-series Analysis of Line Profile Variability in Optical Spectra of ε Orionis." University of Toledo / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1249511358.

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Pourghahramani, Parviz. "Effects of grinding variables on structural changes and energy conversion during mechanical activation using line profile analysis (LPA) /." Luleå : Luleå tekniska universitet/Chemical Engineering and Geosciences/Mineral Processing, 2006. http://epubl.ltu.se/1402-1757/2006/19/index.html.

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Topping, Matthew. "An investigation into the formation and stability of dislocation loops in irradiated Zr alloys." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/an-investigation-into-the-formation-and-stability-of-dislocation-loops-in-irradiated-zr-alloys(176ab44b-bf14-4b78-98b0-70058a59624c).html.

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The present PhD project was carried out as part of an EPSRC Leadership Fellowship for the study of irradiation damage in zirconium alloys. The National Nuclear Laboratory (NNL) directly supported the project in terms of additional funding and insightful discussions regarding irradiation damage in zirconium alloys. The research carried out within the project aims to gain a better understanding of both a- and c-loops, formed during irradiation damage in zirconium alloys. A range of techniques have been utilised to assess the morphology and density of the dislocation loops after proton-irradiations. These techniques include transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS) and line profile analysis (LPA) using synchrotron X-ray diffraction (SXRD) profiles and analysing the data utilizing the extended convolutional multiple whole profile (CMWP) analysis software. The effect of experimental conditions on dislocation loop formation and stability of a-loops during post-irradiation annealing have also been investigated. Proton-irradiations were carried out on the commercial alloys Zircaloy-2, Optimized ZIRLOTM and also on binary Zr-0.1Fe and Zr-0.6Fe alloys. A mechanism has been proposed as to the effect of Fe redistribution on dislocation loop formation. By comparing proton-irradiated Zr-0.1Fe and Zircaloy-2 alloys it was possible to investigate the effect of increased amount of Fe redistribution, which occurs from secondary phase particle (SSP) dissolution, on the microstructural features that develop during irradiation. Zircaloy-2 has a higher density of SPPs and these are more homogenously distributed throughout the matrix in comparison to the Zr3Fe SPPs found in the Zr-0.1Fe alloy. It was found that Fe redistribution facilitates the formation of Fe-rich nano-precipitation. Bright-field STEM imaging has been used to image a- and c-loops and it was found that Zircaloy-2 had a lower dislocation line density compared to Zr-0.1Fe for both types of loops at similar damage levels. Therefore it has been proposed that Fe redistributed from SPPs precipitates in the matrix and the subsequent irradiation-induced precipitates act as annihilation sites for point defects; therefore preventing the formation of new dislocation loops and the growth of existing loops. In order to assess the effect of proton-irradiation temperature on a-loops, Zircaloy-2 and Optimized ZIRLOTM were proton irradiated to 2.3 dpa at 280°C, 350°C and 450°C. It was found that the a-loop density dropped in both alloys as irradiation temperature was increased and the a-loop diameter decreased. The changes in the density and size were more dramatic in Zircaloy-2 and this was explained by the presence of fine irradiation induced clustering of Nb seen in Optimized ZIRLOTM. These trends were calculated from both STEM imaging and CMWP, highlighting the suitability of using CMWP to investigate irradiation-induced dislocations. Finally the stability of the a-loops in proton-irradiated Zr-Fe binary alloys were investigated using novel in-situ SXRD and TEM annealing experiments. From CMWP analysis of the profiles generated during the in-situ annealing of a Zr-0.6Fe 3 dpa sample it was shown that the majority of the annealing takes place between 300°C-400°C. This was highlighted by a period of no change in the dislocation density up to 300°C, after which the density drops dramatically. In-situ annealing of a 1.5 dpa Zr-0.1Fe sample in the TEM allowed for the observation of a-loop gliding along prismatic planes enabling the annealing process taking place between 280°C-450°C, i.e. a similar temperature range at which SXRD analysis indicates the greatest level of annealing.

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Beyerlein, Kenneth Roy. "Simulation and modeling of the powder diffraction pattern from nanoparticles: studying the influence of surface strain." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41211.

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Accurate statistical characterization of nanomaterials is crucial for their use in emerging technologies. This work investigates how different structural characteristics of metal nanoparticles influence the line profiles of the corresponding powder diffraction pattern. The effects of crystallite size, shape, lattice dynamics, and surface strain are all systematically studied in terms of their impact on the line profiles. The studied patterns are simulated from atomistic models of nanoparticles via the Debye function. This approach allows for the existing theories of diffraction to be tested, and extended, in an effort to improve the characterization of small crystallites. It also begins to allow for the incorporation of atomistic simulations into the field of diffraction. Molecular dynamics simulations are shown to be effective in generating realistic structural models and dynamics of an atomic system, and are then used to study the observed features in the powder diffraction pattern. Furthermore, the characterization of a sample of shape controlled Pt nanoparticles is carried out through the use of a developed Debye function analysis routine in an effort to determine the predominant particle shape. The results of this modeling are shown to be in good agreement with complementary characterization methods, like transmission electron microscopy and cyclic voltammetry.

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PAPITTO, ALESSANDRO. "Analysis of the rotational behaviour and evolutionary scenarios of Accreting Millisecond Pulsars." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/812.

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In questo studio viene presentata un'analisi dell'evoluzione rotazionale ed orbitale delle Pulsar X al millisecondo (AMSP). Queste sorgenti sono delle stelle di neutroni (NS) che emettono energia in raggi X accrescendo la materia trasferita da una stella compagna, tramite un disco di accrescimento. Poichè le AMSP poseggono una magnetosfera che interrompe il flusso di materia nel disco prima della superficie, concentrando l'accrescimento nelle vicinanze dei poli magnetici, l'emissione X è pulsata al periodo di rotazione della stella, che è di qualche millisecondo per una AMSP. Il mio progetto di ricerca si basa sull'utilizzo di questa proprietà fondamentale per valutare la reazione della NS all'accrescimento di materia. Infatti le particelle di un disco di accrescimento posseggono un elevato momento angolare specifico, specialmente nelle vicinanze della NS; quando la materia viene accresciuta il suo momento angolare viene rilasciato alla stella, che tende quindi ad accellerare. E' proprio questo meccanismo che ha condotto le AMSP alla estrema velocità di rotazione attuale (un decimo della velocità della luce). Avendo a disposizione un tale orologio solidale alla stella, ho utilizzato le pulsazioni X provenienti dalla superficie per misurare le piccole variazioni della frequenza di rotazione della NS mentre accresce massa. Se ne trae quindi una misura delle coppie che agiscono su di essa e la stima delle grandezze che le regolano, principalmente il tasso di accrescimento di massa e l'intensità del campo magnetico della NS. Tali misure sono estremamente delicate, specialmente nel caso delle AMSP. Infatti queste sorgenti accrescono massa al più per qualche mese ed, a causa dell'elevata inerzia di una NS, la variazione di frequenza attesa è solamente di poche parti su dieci miliardi. Innanzi tutto le tecniche standard di timing sono state quindi adattate al caso particolare di questi oggetti, permettendo per la prima volta una misura affidabile del loro stato rotazionale. Sono state prese in considerazione sei delle dieci AMSP scoperte sin ora. In particolare, le due alle quali mi sono dedicato maggiormente mostrano adeguatamente come il semplice schema di accellerazione della NS delineato sopra non valga in ogni caso, e come una AMSP possa anche decelerare durante l'accrescimento. La causa di tale decelerazione è individuata dalla teoria dell'accrescimento nell'interazione tra il campo magnetico e il disco di accrescimento, interazione che può quindi rallentare la stella specialmente se questa ruota molto rapidamente. In questo lavoro mostro come questi rallentamenti vengono effettivamente osservati e come consentano di ottenere stime del campo magnetico della NS. Gli elementi basilari delle teorie dell'accrescimento su un rotatore veloce sono stati testati non solo sulla base dei risultati dell'analisi temporale. Si mostra infatti come le attese teoriche siano supportate anche alla luce dell'informazione spettrale. In particolare l'osservazione di una AMSP mostra la presenza di una riga del ferro molto larga nel suo spettro in raggi X. Essendo la regione interna del disco di accrescimento l'unica possibile regione di formazione di una riga così larga, è stato possibile misurare, per la prima volta nel caso di una pulsar, l'estensione del bordo interno del disco. Il valore misurato è perfettamente in accordo con il ristretto intervallo permesso dalla teoria, rappresentando così una verifica fondamentale della sua consistenza. L'analisi temporale consente inoltre di valutare l'evoluzione orbitale del sistema binario al quale appartiene la NS. Nell'unico caso di un sistema che abbia mostrato più di un episodio di attività, si è trovata evidenza di una evoluzione molto più rapida di quella attesa. Questo comportamento può essere spiegato solo in termini di rilevanti perdite di massa, massa che porta con sé la quantità di momento angolare necessaria per rendere conto dell'evoluzione misurata. Ciò supporta inoltre l'ipotesi che tali perdite di massa siano dovute all'accensione di una pulsar alimentata dalla rotazione durante le sue fasi di quiete del sistema. Questo può in definitiva essere considerato uno dei pochi casi astrofisici in cui viene osservata in tempo reale un'evoluzione altamente non conservativa. I risultati presentati in questa tesi coprono quindi molti aspetti della fisica di questi sistemi, mostrando come l'unione dell'analisi temporale e spettrale possa fornire una gran quantità di informazioni su questi sistemi estremi e per certi versi sconcertanti. In definitiva sono state confermate le attese teoriche di base sull'accrescimento su NS veloci, ma si aprono anche diverse questioni che promettono di gettare maggiore luce sulla fisica dell'ambiente immediatamente circostante la stella e sull'effettiva linea evolutiva delle AMSP.
I present in this study an analysis of the spin and orbital evolution of Accreting Millisecond Pulsars (AMSP). These sources are neutron stars (NS) emitting X-rays because of the accretion of mass transferred by a nearby companion star through an accretion disc. As AMSP owns a magnetosphere that truncates the disc before the NS, thus channelling accreted matter in the vicinity of the magnetic poles, their X-ray emission is pulsed at the NS spin period, which is of few milliseconds in an AMSP. My scientific project relies on the use this invaluable property to evaluate the rotational reaction of the NS to the accretion of mass. As a matter of fact, mass orbiting in an accretion disc has a large specific angular momentum especially close to the NS; when this matter is accreted, it releases its angular momentum to the NS that is therefore expected to accelerate. It is indeed through this mechanism that AMSP have been spun up to their extreme rotational velocities (up to 0.1 times the speed of light in vacuum). I therefore used the X-ray pulsations coming from the NS surface as a clock to precisely measure the tiny variations of the accretor spin frequency as it accretes. This is ultimately a measure of the accretion torques acting on the NS and allows a model dependent estimate of the physical quantities regulating these torques, mainly the rate at which mass is accreted on the NS and the magnetic field straight. Such measurements can be very tricky especially for AMSP. They accrete mass for at most few months, and because of to the large inertia of a NS, the expected frequency variations are of only few parts on ten billions. Standard timing techniques were therefore first tailored to the particular case of these sources, allowing for the first time reliable estimates of their spin state. Six among the ten AMSP discovered so far are considered in this work. In particular, the two sources I focused on the most show how the simple picture of the NS spin-up outlined above does not hold in every case, as the outcome of the accretion can also be the deceleration of the NS. The reason for this behaviour is interpreted by the accretion theory in terms of the interaction between the magnetic field and the accretion disc. This interaction may then brake of the compact object especially if it is very fast. I show in this work how these spin-down are effectively observed and how this allows an estimate of the NS magnetic field. The basics of the accretion picture onto a fast object are tested not only on the basis of a temporal analysis. I show in fact how the spectral information also supports the theoretical expectations. In particular a high spectral resolution observation of a AMSP shows the presence of a broadened iron line in its X-ray spectrum. The only viable location for the formation of a line so broadened is the inner part of the accretion disc, thus allowing for the first time the measure of the size of the inner disc rim of a pulsar. This measure is perfectly consistent with the small range allowed by theory, thus representing a fundamental test of their consistency. Temporal analysis also allows to enlighten the evolution of the binary system the NS belongs to. In the only case of a system which recurred more than once, we could find evidence of a faster than expected evolution. We interpret such behaviour as an indication of relevant mass lost which carries away the angular momentum needed to match the observations. This supports the hypothesis that a rotation powered pulsar switches on during the quiescent phases of the binary. Moreover, this observation can be considered as one of the few astrophysical cases in which a highly non conservative evolution was directly observed. The results presented in this thesis cover many aspects of the physics of these fast accretors, and show how X-ray temporal and spectral analysis can jointly supply a wealth of information on the physical state of these extreme and puzzling systems. These results confirm the basic theoretical expectations but open also several issues which are very promising to shed some light in particular on the environment surrounding these fast rotating NS and on their actual evolutionary progeny.

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Benredjem, Djamel. "Etude théorique du déplacement des raies spectrales par effet de polarisation dans les plasmas denses : cas des raies de l'hélium hydrogenoïde." Paris 6, 1986. http://www.theses.fr/1986PA066016.

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Le déplacement des raies de l'hélium hydrogenoïde émises dans les plasmas denses a été calculé en considérant l'effet des électrons libres et celui des ions perturbateurs sur l'émetteur. Le premier, déterminé par une méthode de potentiel auto-consistant, induit un déplacement vers le rouge alors que le second, calcule par perturbation, décale les raies vers le bleu. Deux méthodes de calcul de cette grandeur ont été développées : l'une permet d'évaluer le déplacement comme moment spectral du profil complet; l'autre, plus simple, séparé les deux contributions et peut s'appliquer à des états très excités. Les résultats théoriques obtenus sont en accord quantitatif avec les expériences les plus récentes.

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Khemiri, Rym. "Vers l'OLAP collaboratif pour la recommandation des analyses en ligne personnalisées." Thesis, Lyon 2, 2015. http://www.theses.fr/2015LYO22015/document.

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La personnalisation vise à recueillir les intérêts, les préférences, les usages, les contraintes, le contexte, etc. souvent considérés comme faisant partie de ce que l'on appelle ''profil utilisateur'' pour ensuite les intégrer dans un système et les exploiter afin de permettre à l'utilisateur d'accéder rapidement aux informations les plus pertinentes pour lui. Par ailleurs, au sein d'une organisation, différents acteurs sont amenés à prendre des décisions à différents niveaux de responsabilité et ont donc besoin de réaliser des analyses à partir de l'entrepôt de données pour supporter la prise de décision. Ainsi, dans le contexte de cette communauté d'utilisateurs de l'entrepôt de données, la notion de collaboration émerge. Il est alors intéressant de combiner les concepts de personnalisation et de collaboration pour approcher au mieux les besoins des utilisateurs en leur recommandant des analyses en ligne pertinentes. L'objectif de ce mémoire est de proposer une approche collaborative pour l'OLAP, impliquant plusieurs utilisateurs, dirigée par un processus de personnalisation intégré aux systèmes décisionnels afin de pouvoir aider l'utilisateur final dans son processus d'analyse en ligne. Qu'il s'agisse de personnalisation du modèle d'entrepôt, de recommandation de requêtes décisionnelles ou de recommandation de chemins de navigation au sein des cubes de données, l'utilisateur a besoin d'un système décisionnel efficace qui l'aide dans sa démarche d'analyse en ligne. La finalité est de fournir à l'utilisateur des réponses pertinentes proches de ses besoins pour qu'il puisse mieux appréhender ses prises de décision. Nous nous sommes intéressés dans cette thèse à trois problèmes relevant de la prise en compte de l'utilisateur au sein des entrepôts de données et de l'OLAP. Nos contributions s'appuient sur la combinaison de techniques issues de la fouille de données avec les entrepôts et OLAP. Notre première contribution est une approche qui consiste à personnaliser les hiérarchies de dimensions afin d'obtenir des axes d'analyse nouveaux sémantiquement plus riches pouvant aider l'utilisateur à réaliser de nouvelles analyses non prévues par le modèle de l'entrepôt initial. En effet, nous relâchons la contrainte du modèle fixe de l'entrepôt, ce qui permet à l'utilisateur de créer de nouveaux axes d'analyse pertinents en tenant compte à la fois de ses contraintes et des connaissances enfouies dans les données entreposées. Notre approche repose sur une méthode d'apprentissage non-supervisé, le k-means contraint, capable de créer de nouveaux regroupements intéressants des données entreposées pouvant constituer un nouveau niveau de hiérarchie permettant de réaliser de nouvelles requêtes décisionnelles. L'intérêt est alors de pouvoir exploiter ces nouveaux niveaux de hiérarchie pour que les autres utilisateurs appartenant à la même communauté d'utilisateurs puissent en tirer profit, dans l'esprit d'un système collaboratif dans lequel chacun apporte sa pierre à l'édifice. Notre deuxième contribution est une approche interactive pour aider l'utilisateur à formuler de nouvelles requêtes décisionnelles pour construire des cubes OLAP pertinents en s'appuyant sur ses requêtes décisionnelles passées, ce qui lui permet d'anticiper sur ses besoins d'analyse futurs. Cette approche repose sur l'extraction des motifs fréquents à partir d'une charge de requêtes associée à un ou à un ensemble d'utilisateurs appartenant à la même communauté d'acteurs d'une organisation. Notre intuition est que la pertinence d'une requête décisionnelle est fortement corrélée avec la fréquence d'utilisation par l'utilisateur (ou un ensemble d'utilisateurs) des attributs associés à l'ensemble de ses (leurs) requêtes précédentes. Notre approche de formulation de requêtes (...)
The objective of this thesis is to provide a collaborative approach to the OLAP involving several users, led by an integrated personalization process in decision-making systems in order to help the end user in their analysis process. Whether personalizing the warehouse model, recommending decision queries or recommending navigation paths within the data cubes, the user need an efficient decision-making system that assist him. We were interested in three issues falling within data warehouse and OLAP personalization offering three major contributions. Our contributions are based on a combination of datamining techniques with data warehouses and OLAP technology. Our first contribution is an approach about personalizing dimension hierarchies to obtain new analytical axes semantically richer for the user that can help him to realize new analyzes not provided by the original data warehouse model. Indeed, we relax the constraint of the fixed model of the data warehouse which allows the user to create new relevant analysis axes taking into account both his/her constraints and his/her requirements. Our approach is based on an unsupervised learning method, the constrained k-means. Our goal is then to recommend these new hierarchy levels to other users of the same user community, in the spirit of a collaborative system in which each individual brings his contribution. The second contribution is an interactive approach to help the user to formulate new decision queries to build relevant OLAP cubes based on its past decision queries, allowing it to anticipate its future analysis needs. This approach is based on the extraction of frequent itemsets from a query load associated with one or a set of users belonging to the same actors in a community organization. Our intuition is that the relevance of a decision query is strongly correlated to the usage frequency of the corresponding attributes within a given workload of a user (or group of users). Indeed, our approach of decision queries formulation is a collaborative approach because it allows the user to formulate relevant queries, step by step, from the most commonly used attributes by all actors of the user community. Our third contribution is a navigation paths recommendation approach within OLAP cubes. Users are often left to themselves and are not guided in their navigation process. To overcome this problem, we develop a user-centered approach that suggests the user navigation guidance. Indeed, we guide the user to go to the most interesting facts in OLAP cubes telling him the most relevant navigation paths for him. This approach is based on Markov chains that predict the next analysis query from the only current query. This work is part of a collaborative approach because transition probabilities from one query to another in the cuboids lattice (OLAP cube) is calculated by taking into account all analysis queries of all users belonging to the same community. To validate our proposals, we present a support system user-centered decision which comes in two subsystems: (1) content personalization and (2) recommendation of decision queries and navigation paths. We also conducted experiments that showed the effectiveness of our analysis online user centered approaches using quality measures such as recall and precision

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Beyerlein, Kenneth Roy. "Simulation and Modeling of the Powder Diffraction Pattern from Nanoparticles: Studying the Effects of Faulting in Small Crystallites." Doctoral thesis, Università degli studi di Trento, 2011. https://hdl.handle.net/11572/368693.

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Accurate statistical characterization of nanomaterials is crucial for their use in emerging technologies. This work investigates how different structural characteristics of metal nanoparticles influence the line profiles of the corresponding powder diffraction pattern. The effects of crystallite size, shape, lattice dynamics, and faulting are all systematically studied in terms of their impact on the line profiles. The studied patterns are simulated from atomistic models of nanoparticles via the Debye function. This approach allows for the existing theories of diffraction to be tested, and extended, in an effort to improve the characterization of small crystallites. It also begins to allow for the incorporation of atomistic simulations into the field of diffraction. Molecular dynamics simulations are shown to be effective in generating realistic structural models and dynamics of an atomic system, and are then used to study the observed features in the powder diffraction pattern. Furthermore, the characterization of a sample of shape controlled Pt nanoparticles is carried out through the use of a developed Debye function analysis routine in an effort to determine the predominant particle shape. The results of this modeling are shown to be in good agreement with complementary characterization methods, like transmission electron microscopy and cyclic voltammetry.

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Cohen, D. H., M. A. Leutenegger, and R. H. D. Townsend. "Quantitative analysis of resolved X-ray emission line profiles of O stars." Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2008/1811/.

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By quantitatively fitting simple emission line profile models that include both atomic opacity and porosity to the Chandra X-ray spectrum of ζ Pup, we are able to explore the trade-offs between reduced mass-loss rates and wind porosity. We find that reducing the mass-loss rate of ζ Pup by roughly a factor of four, to 1.5 × 10−6 M⊙ yr−1, enables simple non-porous wind models to provide good fits to the data. If, on the other hand, we take the literature mass-loss rate of 6×10−6 M⊙ yr−1, then to produce X-ray line profiles that fit the data, extreme porosity lengths – of h∞ ≈ 3 R∗ – are required. Moreover, these porous models do not provide better fits to the data than the non-porous, low optical depth models. Additionally, such huge porosity lengths do not seem realistic in light of 2-D numerical simulations of the wind instability.

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Butchar, Jonathan P. "Microarray analysis of drosophila EGF receptor signaling and cell line expression profiles." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1141824872.

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Crenshaw, Daniel Michael. "An analysis of the broad emmission line profiles of Seyfert 1 galaxies /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487260135357676.

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Bradshaw, Emma. "Intrinsic and extrinsic aspirations and psychological well-being: a meta-analysis and latent profile analyses of life goals." Thesis, Australian Catholic University, 2019. https://acuresearchbank.acu.edu.au/download/19ce043e15af9a376182be73c2398fb8555b481f94ac7417dbae472c8e99d54f/3511870/BRADSHAW_2019_Intrinsic_and_extrinsic_aspirations.pdf.

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Goal contents theory (Kasser & Ryan, 1993, 1996, 2001; Ryan & Deci, 2017) holds that intrinsic life goals (personal growth, relationships, community giving, and health) and extrinsic life goals (wealth, fame, and image) differentially relate to psychological well-being. Intrinsic life goals, or aspirations, inherently satisfy basic psychological needs and therefore promote optimal functioning, while an emphasis on extrinsic aspirations represents a reliance on external contingencies which, at best, only indirectly satisfies basic psychological needs. Despite abundant evidence supporting goal contents theory, positive links between extrinsic aspiring and well-being, observed particularly in Eastern European countries, have led some authors to contend that extrinsic aspirations may not be damaging in all contexts (Frost & Frost, 2000; Rijavec, Brdar, & Miljković, 2011). In addition, the frequently observed positive correlation between intrinsic and extrinsic aspirations suggests that they are not universally divergent. Indeed, consistent unexplained heterogeneity in the results indicates there are unobserved sources of heterogeneity in the data, suggesting there may be subgroups with distinct patterns of aspiring. In Chapter 2 of this thesis, a meta-analysis of more than 1’000 effect sizes showed support for the universality of goal contents theory across countries, age groups, and socioeconomic statuses. In Chapters 3, 4, and 5, bifactor structural equation modelling (B-ESEM) was combined with latent profile analysis (LPA) in three large, independent samples from Hungary, Australia, and the United States of America, and derived three replicable profiles of aspiring. Chapters 4 and 5 showed that profile membership predicted additional variance in well-being, even in highly conservative tests that control for the aspirations that comprise the profiles. The profiles also differed in the breadth of their care for others. From Profile 1 to Profile 3, increasingly more (and more distal) others are central in the configurations of aspiring, starting with the self (Profile 1), then close others (Profile 2), and then the world in general (Profile 3). These studies make a unique contribution to the literature by synthesizing the available evidence and by identifying replicable latent profiles of aspiring that account for variance in well-being and other-oriented-ness over and above the constituent variables.

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Ichikawa, Rodrigo Uchida. "Aplicações do método Warren-Averbach de análise de perfis de difração." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-10012014-103427/.

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O objetivo deste trabalho foi desenvolver e implementar uma metodologia envolvendo a análise de perfis de difração de raios X (X-ray Line Profile Analysis - XLPA) para o estudo e determinação do tamanho médio de cristalitos e microdeformação em materiais. Para isto houve o desenvolvimento de um programa computacional para facilitar o tratamento dos picos presentes em um difratograma e realizar a deconvolução de perfis através do Método de Stokes para se corrigir a contribuição instrumental nos perfis de difração. Os métodos de XLPA de espaço real estudados e aplicados neste trabalho foram os métodos de Scherrer, Williamson-Hall e Single-Line (ou Linha Única) e o método de Warren-Averbach de espaço de Fourier. Além disso, utilizando-se um modelamento matemático foi possível calcular a distribuição de tamanhos de cristalitos para um caso isotrópico, onde considerou-se a distribuição log-normal e cristalitos com forma esférica. Foi possível demonstrar que a teoria proposta pode ser considerada como uma boa aproximação avaliando-se uma razão de dispersão. As metodologias descritas acima foram aplicadas em dois materiais distintos: na liga metálica Zircaloy-4 e em ZnO.
The objective of this work was to develop and implement a methodology of X-ray Line Profile Analysis (XLPA) for the study and determination of the mean crystallite sizes and microstrains in materials. A computer program was developed to speed up the treatment of diffraction peaks and perform the deconvolution utilizing the Stokes method to correct the instrumental contribution in the X-ray diffraction measurements. The XLPA methods used were the Scherrer, Williamson-Hall and Single-Line methods, which can be called real space methods, and the Fourier space method of Warren-Averbach. Furthermore, considering a mathematical modelling it was possible to calculate the crystallite size distribution, considering the log-normal distribution and spherical crystallites. It was possible to demonstrate the proposed theory can provide reliable results evaluating a dispersion parameter. The methodologies described above were applied in two distinct materials: in the alloy Zircaloy-4 and in ZnO.

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Llewellyn, Bonny C. "A Profile and Analysis of Repeat Bankruptcy Petitioners in the District of Utah 1984-2004." DigitalCommons@USU, 2005. https://digitalcommons.usu.edu/etd/2849.

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The purpose of this study was to describe the incidence of repeat filers in Utah and estimate the extent that repeat filers may be abusing the bankruptcy system. This study sought to develop a profile of repeat filers . Demographic and financial variables were examined to detem1ine their association with abuser/nonabuser status. In this study, abuse of bankruptcy was characterized only by the timing and number of filings over 20 years. Debtors with three filings in a 2-year period or less and debtors with four or more total filings were classified as abusers. Nonabusers were defined as debtors who filed only once as well as debtors who had two or three scattered filings over the 20-year period. About I I% of the total sample appeared to be abusing the bankruptcy system by filing repeatedly. The majority (76.2%) of the I 997 cases filed by abusers were dismissed while only 23.8% received a discharge of their unsecured debts. Only five (2.9%) of the I 71 abusers who filed chapter I 3 in I 997 completed their payment plan and received a discharge of their debts. The logistic regression model found chapter (7 versus 13), filing status, unsecured debt, and monthly income to be the most significant variables in estimating abuse. Males and females filing alone were nearly 50% less likely than joint filers to be abusers. Chapter 13 debtors are nearly five times as likely to be abusers when compared to chapter 7 debtors. Filers who had unsecured debt levels above the median were less likely to be abusers, and filers who had incomes above the median were almost twice as likely to be abusers. Realistic repayment plans that pay careful attention to construction of budgets and a financial counselor to work with debtors who miss payments is one approach to combating abuse by repeat filing. Judges may need to discipline attorneys who file cases repeatedly. Perhaps a new Code is not what we need to combat abusers; instead, closer monitoring of cases by trustees, more responsible attorneys, and more responsible lending are needed.

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15

Gerhartz, Cody J. "Temporal Variations in The Circumstellar Disks of Be Stars from Analysis of Optical and IR Line Profiles." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501602656319988.

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16

Chien, Yung-hsin. "SHELF LIFE EXTENSION OF SEED BUTTER MADE WITH SESAME, SUNFLOWER AND PUMPKIN SEEDS." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449235219.

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17

Mundy, Jo-Anne Shirley. "Life cycle assessment of UK forest products : evaluation of environmental profiles and analysis of their communication." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/11845.

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18

Tinaglia, V. "INTEGRATED GENOMICS ANALYSIS OF GENE AND MICRORNA EXPRESSION PROFILES IN CLEAR CELL RENAL CARCINOMA CELL LINES." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/169561.

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Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney, accounting for a total of 2-3% of adult neoplasias, and it arises from the renal epithelium. Clear cell renal cell carcinoma (ccRCC) is the most common, invasive and metastatic among RCC subtypes, representing 75-80% of kidney primary malignancies. The von Hippel-Lindau (VHL) gene, which is the main tumor suppressor gene involved in early steps of RCC tumorigenesis, undergoes complete inactivation by mutation, deletion, and promoter methylation in the majority of sporadic ccRCCs and in all inherited forms. Defining the prognosis for RCC cases is important for both decision-making and counseling patients, but sometimes the diagnosis is difficult because tumor subtypes have overlapping histo-pathological features, thus resulting undistinguishable by microscopy investigation. In recent years, in several human cancers, microarray gene expression profiling proved to be a powerful tool to better classify tumor subtypes and to identify novel molecular biomarkers potentially useful for clinical applications. In fact, tumor transcriptomic profiling may identify patterns of genes that are functionally related to patients’ prognosis, response to therapy and overall survival. Recent evidences have shown that microRNA (miRNA) molecules are involved in tumorigenesis, indicating that miRNAs might function as both tumor suppressors and oncogenes, and their role in RCC pathogenesis is now emerging. miRNAs are small single-stranded non-protein-coding RNA molecules, that function as negative post-transcriptional gene regulators in animals, plants and viruses, and are involved in many biological processes, also including haematopoietic cell differentiation, apoptosis, cell proliferation and organ development. miRNA and gene expression patterns are closely related, since they cooperatively work to create gene regulatory networks. Therefore, integrative genomics approach might be a useful tool to elucidate the complex relationships underlying these networks. The aim of my PhD fellowship work was to reconstruct miRNA-gene post-transcriptional regulatory networks involved in RCC biology, using miRNA and gene expression profiles of three RCC cell lines compared to a normal one, obtained by Affymetrix high-density microarray technology. We calculated differentially expressed genes and miRNAs, and, by functional enrichment analysis, we identified genes and miRNAs that were already known to be associated with RCC and involved in relevant pathways for this pathology, such as hypoxia, p53 signaling, focal adhesion, angiogenesis and mTOR signaling. Through integrated analysis of miRNA-gene expression profiles, we reconstructed potentially active regulatory networks involving miRNAs and their predicted target genes. We validated some miRNA-gene pairs by quantitative PCR, thus confirming their anti-correlated expression levels. Our results demonstrated that RCC cell lines can be an useful in vitro model for RCC pathology, since they showed gene and miRNA expression profiles similar to renal tumoral tissues, as obtained by comparing our results with published data. The analysis of the correlations between gene and miRNA expression profiles using a genome-wide integrative approach could help the identification of both post-transcriptional regulatory networks and novel candidate markers functionally relevant for RCC pathology. However, further investigations are necessary to elucidate the actual role of miRNA-gene networks in the context of RCC progression and outcome.

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Arcand, Isabelle. "“I Refuse to Give Up!” A Qualitative Investigation of the Conditions and Experience Undergone by Students on Academic Probation Who Participated in Academic Companioning in a University Context." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23903.

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This study examined the conditions and experience of students who were placed on academic probation in view of key elements of Dewey’s (1958, 1938/1997, 1934/2005) theory of experience. Core data emerged from 16 in-depth interviews with five students who received assistance from an academic support program while on probation. An additional interview was conducted with the academic companion and another with the program developer. A document analysis and a researcher journal supplemented the data. The interviews were analyzed according to a three-dimensional narrative inquiry space (Clandinin & Connelly, 2000; Dewey, 1958, 1938/1997) to produce profiles and thematic connections (Seidman, 2006). Findings are presented in five texts. The first and second manuscripts depict the stories of two students using the profile genre. These texts disclose rich stories where the meaning of experience is lived. A third manuscript examines students’ experience from the student and professional perspectives. Major themes uncovered, include (a) resistance to seek help; (b) deep personal costs; and (c) a desire to succeed and complete their undergraduate studies. A fourth manuscript explores companioning as experienced by students and supported by resource personnel. It reveals that (a) the companioning role was defined by a specific form of guidance and attendance to self-confidence and (b) the program helped students clarify their needs, promoted their adaptation to the university context, and offered support through a positive relationship. A fifth manuscript examined the characteristics of a fruitful helping relationship. Findings suggest that (a) a rapport characterized by presence and trust and (b) an approach promoting responsibility, awareness, and holism were key. These findings offer a weighty contribution to the literature on post-secondary education by revealing rich and unique experiences. By tapping in the complexity of the participants’ experience, findings help shift away from the current focus on obstacles and deficiencies often attributed to probationary students. Résumé Cette étude a examiné l’expérience d’étudiants ayant été placés en probation académique à la lumière d’éléments-clés de la théorie de l’expérience de Dewey (1958, 1938/1997, 1934/2005). La principale source de données provenait de 16 entrevues en profondeur auprès de cinq étudiants ayant participé à un programme d’accompagnement universitaire alors qu’ils étaient en probation académique. Une entrevue a aussi été menée avec l’accompagnatrice et une autre avec la conceptrice du programme. Une analyse documentaire et un journal de bord de la chercheure complètent les données. Les entrevues ont été analysées selon une analyse narrative tridimensionnelle (Clandinin & Connelly, 2000; Dewey, 1958, 1938/1997) de façon à produire des profils et des liens thématiques (Seidman, 2006). Les résultats sont présentés dans cinq textes. Les premier et deuxième textes dépeignent l’histoire de deux étudiants sous forme de profils. Ces textes découvrent de riches et profondes histoires véhiculant la probation comme expérience de vie et la signification attribuée à celle-ci. Le troisième texte présente l’examen collectif de l’expérience des cinq étudiants ayant participé au programme d’accompagnement. Cette analyse est enrichie des perspectives de l’accompagnatrice et de la conceptrice du programme. Trois thèmes se dégagent de l’expérience de ces étudiants en probation académique soit (a) une résistance à faire usage des services de soutien; (b) des coûts personnels considérables; et (c) un désir de réussir et de compléter leur programme d’études. Un quatrième texte explore l’expérience d’accompagnement tel que perçu par les étudiants et les professionnels. L’analyse révèle que (a) l’accompagnatrice agissait à titre de guide et était attentive à la dimension de la confiance en soi et (b) le programme a aidé les étudiants à identifier leurs besoins, a soutenu leur adaptation au contexte universitaire, et a offert un soutien personnalisé par l’entremise d’une relation d’aide positive. Le cinquième texte se concentre sur les particularités d’une relation d’aide efficace en contexte de probation académique. Les résultats relèvent que cette expérience est qualifiée par (a) un rapport de présence empathique et empreinte de confiance réciproque et (b) une approche globale favorisant la responsabilité et la conscientisation. En dévoilant la richesse et l’unicité de l’expérience, ces résultats offrent une contribution intéressante. Illustrant la complexité des expériences de probation ils contribuent à s’éloigner d’une vision centrée sur les obstacles et les déficits des étudiants en probation académique.

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Little, Jonathon. "Multilevel and longitudinal factor structure of the life skills profile-16 : an application of multilevel covariance structure analysis and its variants." Phd thesis, Canberra, ACT : The Australian National University, 2015. http://hdl.handle.net/1885/151122.

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21

Wittchen, Hans-Ulrich, Silke Behrendt, Michael Höfler, Axel Perkonigg, Jürgen Rehm, Roselind Lieb, and Katja Beesdo. "A typology of cannabis-related problems among individuals with repeated illegal drug use in the first three decades of life: Evidence for heterogeneity and different treatment needs." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-111264.

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Background: Cannabis use (CU) and disorders (CUD) are highly prevalent among adolescents and young adults. We aim to identify clinically meaningful latent classes of users of cannabis and other illegal substances with distinct problem profiles. Methods: N= 3021 community subjects aged 14–24 at baseline were followed-up over a period ranging up to 10 years. Substance use (SU) and disorders (SUD) were assessed with the DSM-IV/M-CIDI. Latent class analysis (LCA) was conducted with a subset of N= 1089 subjects with repeated illegal SU. The variables entered in the LCA were CU-related problems, CUD, other SUD, and other mental disorders. Results: Four latent classes were identified: “Unproblematic CU” (class 1: 59.2%), “Primary alcohol use disorders” (class 2: 14.4%), “Delinquent cannabis/alcohol DSM-IV-abuse” (class 3: 17.9%), “CUD with multiple problems” (class 4: 8.5%). Range and level of CU-related problems were highest in classes 3 and 4. Comorbidity with other mental disorders was highest in classes 2 and 4. The probability of alcohol disorders and unmet treatment needs was considerable in classes 2–4. Conclusion: While the majority of subjects with repeated illegal SU did not experience notable problems over the 10-year period, a large minority (40.8%) experienced problematic outcomes, distinguished by clinically meaningful profiles. The data underline the need for specifically tailored interventions for adolescents with problematic CU and highlight the potentially important role of alcohol and other mental disorders.

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22

Yorgancioglu, Kaan. "Using Anchor Nodes for Link Prediction." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1578499802599777.

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23

Gaveau, David. "Emergence de l’identité tutorale : fonctions et profils de tuteurs dans un cours en ligne de FLE." Thesis, Bourgogne Franche-Comté, 2019. http://www.theses.fr/2019UBFCC016.

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Notre projet de recherche trouve ses racines dans le projet PrépaFLE, dispositif de formation en ligne tutoré qui a pour objectif de préparer les étudiants japonais en FLE avant leur arrivée en France. Afin de contextualiser notre problématique de recherche qui cherche à caractériser les fonctions tutorales déployées au sein de ce dispositif de formation en ligne, nous choisirons d’analyser les échanges entre tuteurs et apprenants japonais. Afin de nous aider dans notre recherche, nous passerons en revue les différents principes théoriques qui nourrissent le champ de la recherche en didactique des langues étrangères et plus particulièrement du français langue étrangère dans le cadre de l’utilisation pédagogique des environnements numériques. Partant de résultats de recherche, nous exposerons le concept de Community of Inquiry qui permet de poser les contours d’une présence tutorale. Nous nous appuierons également sur les résultats de travaux s’intéressant aux catégories de fonctions tutorales identifiées chez les enseignants engagés dans dispositif de FOAD à travers l’analyse de discours de ces derniers. La démarche méthodologique retenue nous permettra de positionner notre recherche dans le cadre d’une recherche descriptive convoquant l’analyse de discours. Notre analyse de discours s’appuiera en même temps sur une approche pragmatique qualitative convoquant le concept d’acte de parole et sur une analyse de contenu de nature quantitative qui visera à classer les actes de paroles identifiés dans notre corpus. Notre analyse fera apparaître que les tuteurs développent différents profils en fonction de la proportion des fonctions tutorales qu’ils déploient à travers leur discours
Our research project has its roots in the PrépaFLE project, a tutored online training device that aims to prepare Japanese students in FLE before their arrival in France. In order to contextualize our research problem that seeks to characterize the tutorial functions deployed within this online training device, we will choose to analyze the exchanges between tutors and Japanese learners. To help us in our research, we will review the different theoretical principles that nourish the field of research in the teaching of foreign languages and more particularly French as a foreign language in the context of the pedagogical use of digital environments. Starting from research results, we will expose the concept of Community of Inquiry which allows to lay the contours of a tutorial presence. We will also rely on the results of studies looking at the categories of tutorial functions identified in the teachers engaged in ODL device through the discourse analysis of the latter. The methodological approach chosen will enable us to position our research within the framework of a descriptive research that calls for discourse analysis. At the same time, our discourse analysis will be based on a qualitative pragmatic approach that calls for the concept of a speech act and a quantitative content analysis that will classify the acts of speech identified in our corpus. Our analysis will show that tutors develop different profiles according to the proportion of tutorial functions that they deploy through their speech

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24

Wittchen, Hans-Ulrich, Silke Behrendt, Michael Höfler, Axel Perkonigg, Jürgen Rehm, Roselind Lieb, and Katja Beesdo. "A typology of cannabis-related problems among individuals with repeated illegal drug use in the first three decades of life: Evidence for heterogeneity and different treatment needs." Technische Universität Dresden, 2009. https://tud.qucosa.de/id/qucosa%3A26837.

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Background: Cannabis use (CU) and disorders (CUD) are highly prevalent among adolescents and young adults. We aim to identify clinically meaningful latent classes of users of cannabis and other illegal substances with distinct problem profiles. Methods: N= 3021 community subjects aged 14–24 at baseline were followed-up over a period ranging up to 10 years. Substance use (SU) and disorders (SUD) were assessed with the DSM-IV/M-CIDI. Latent class analysis (LCA) was conducted with a subset of N= 1089 subjects with repeated illegal SU. The variables entered in the LCA were CU-related problems, CUD, other SUD, and other mental disorders. Results: Four latent classes were identified: “Unproblematic CU” (class 1: 59.2%), “Primary alcohol use disorders” (class 2: 14.4%), “Delinquent cannabis/alcohol DSM-IV-abuse” (class 3: 17.9%), “CUD with multiple problems” (class 4: 8.5%). Range and level of CU-related problems were highest in classes 3 and 4. Comorbidity with other mental disorders was highest in classes 2 and 4. The probability of alcohol disorders and unmet treatment needs was considerable in classes 2–4. Conclusion: While the majority of subjects with repeated illegal SU did not experience notable problems over the 10-year period, a large minority (40.8%) experienced problematic outcomes, distinguished by clinically meaningful profiles. The data underline the need for specifically tailored interventions for adolescents with problematic CU and highlight the potentially important role of alcohol and other mental disorders.

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25

Andorf, Sandra. "A systems biological approach towards the molecular basis of heterosis in Arabidopsis thaliana." Phd thesis, Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5117/.

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Heterosis is defined as the superiority in performance of heterozygous genotypes compared to their corresponding genetically different homozygous parents. This phenomenon is already known since the beginning of the last century and it has been widely used in plant breeding, but the underlying genetic and molecular mechanisms are not well understood. In this work, a systems biological approach based on molecular network structures is proposed to contribute to the understanding of heterosis. Hybrids are likely to contain additional regulatory possibilities compared to their homozygous parents and, therefore, they may be able to correctly respond to a higher number of environmental challenges, which leads to a higher adaptability and, thus, the heterosis phenomenon. In the network hypothesis for heterosis, presented in this work, more regulatory interactions are expected in the molecular networks of the hybrids compared to the homozygous parents. Partial correlations were used to assess this difference in the global interaction structure of regulatory networks between the hybrids and the homozygous genotypes. This network hypothesis for heterosis was tested on metabolite profiles as well as gene expression data of the two parental Arabidopsis thaliana accessions C24 and Col-0 and their reciprocal crosses. These plants are known to show a heterosis effect in their biomass phenotype. The hypothesis was confirmed for mid-parent and best-parent heterosis for either hybrid of our experimental metabolite as well as gene expression data. It was shown that this result is influenced by the used cutoffs during the analyses. Too strict filtering resulted in sets of metabolites and genes for which the network hypothesis for heterosis does not hold true for either hybrid regarding mid-parent as well as best-parent heterosis. In an over-representation analysis, the genes that show the largest heterosis effects according to our network hypothesis were compared to genes of heterotic quantitative trait loci (QTL) regions. Separately for either hybrid regarding mid-parent as well as best-parent heterosis, a significantly larger overlap between the resulting gene lists of the two different approaches towards biomass heterosis was detected than expected by chance. This suggests that each heterotic QTL region contains many genes influencing biomass heterosis in the early development of Arabidopsis thaliana. Furthermore, this integrative analysis led to a confinement and an increased confidence in the group of candidate genes for biomass heterosis in Arabidopsis thaliana identified by both approaches.
Als Heterosis-Effekt wird die Überlegenheit in einem oder mehreren Leistungsmerkmalen (z.B. Blattgröße von Pflanzen) von heterozygoten (mischerbigen) Nachkommen über deren unterschiedlich homozygoten (reinerbigen) Eltern bezeichnet. Dieses Phänomen ist schon seit Beginn des letzten Jahrhunderts bekannt und wird weit verbreitet in der Pflanzenzucht genutzt. Trotzdem sind die genetischen und molekularen Grundlagen von Heterosis noch weitestgehend unbekannt. Es wird angenommen, dass heterozygote Individuen mehr regulatorische Möglichkeiten aufweisen als ihre homozygoten Eltern und sie somit auf eine größere Anzahl an wechselnden Umweltbedingungen richtig reagieren können. Diese erhöhte Anpassungsfähigkeit führt zum Heterosis-Effekt. In dieser Arbeit wird ein systembiologischer Ansatz, basierend auf molekularen Netzwerkstrukturen verfolgt, um zu einem besseren Verständnis von Heterosis beizutragen. Dazu wird eine Netzwerkhypothese für Heterosis vorgestellt, die vorhersagt, dass die heterozygoten Individuen, die Heterosis zeigen, mehr regulatorische Interaktionen in ihren molekularen Netzwerken aufweisen als die homozygoten Eltern. Partielle Korrelationen wurden verwendet, um diesen Unterschied in den globalen Interaktionsstrukturen zwischen den Heterozygoten und ihren homozygoten Eltern zu untersuchen. Die Netzwerkhypothese wurde anhand von Metabolit- und Genexpressionsdaten der beiden homozygoten Arabidopsis thaliana Pflanzenlinien C24 und Col-0 und deren wechselseitigen Kreuzungen getestet. Arabidopsis thaliana Pflanzen sind bekannt dafür, dass sie einen Heterosis-Effekt im Bezug auf ihre Biomasse zeigen. Die heterozygoten Pflanzen weisen bei gleichem Alter eine höhere Biomasse auf als die homozygoten Pflanzen. Die Netzwerkhypothese für Heterosis konnte sowohl im Bezug auf mid-parent Heterosis (Unterschied in der Leistung des Heterozygoten im Vergleich zum Mittelwert der Eltern) als auch auf best-parent Heterosis (Unterschied in der Leistung des Heterozygoten im Vergleich zum Besseren der Eltern) für beide Kreuzungen für die Metabolit- und Genexpressionsdaten bestätigt werden. In einer Überrepräsentations-Analyse wurden die Gene, für die die größte Veränderung in der Anzahl der regulatorischen Interaktionen, an denen sie vermutlich beteiligt sind, festgestellt wurde, mit den Genen aus einer quantitativ genetischen (QTL) Analyse von Biomasse-Heterosis in Arabidopsis thaliana verglichen. Die ermittelten Gene aus beiden Studien zeigen eine größere Überschneidung als durch Zufall erwartet. Das deutet darauf hin, dass jede identifizierte QTL-Region viele Gene, die den Biomasse-Heterosis-Effekt in Arabidopsis thaliana beeinflussen, enthält. Die Gene, die in den Ergebnislisten beider Analyseverfahren überlappen, können mit größerer Zuversicht als Kandidatengene für Biomasse-Heterosis in Arabidopsis thaliana betrachtet werden als die Ergebnisse von nur einer Studie.

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26

Zillmer, Stephanie [Verfasser], Michaela [Akademischer Betreuer] [Gutachter] Nathrath, and Stefan [Gutachter] Burdach. "Integrative analysis of microRNA and mRNA expression profiles in osteosarcoma cell lines / Stephanie Zillmer. Betreuer: Michaela Nathrath. Gutachter: Michaela Nathrath ; Stefan Burdach." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1106382161/34.

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27

Chaabi, Youness. "Apport des Systèmes Multi-Agent et de la logique floue pour l'assistance au tuteur dans une communauté d'apprentissage en ligne." Thesis, Belfort-Montbéliard, 2016. http://www.theses.fr/2016BELF0293/document.

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La place importante du tutorat dans la réussite d'un dispositif de formation en ligne a ouvert un nouvel axe de recherche dans le domaine des EIAH (Environnements Informatiques pour l'Apprentissage Humain). Nos travaux se situent plus particulièrement dans le champ de recherches des ACAO. Dans un contexte collaboratif, le tutorat et les outils « d'awareness » constituent des solutions admises pour faire face à l'isolement qui très souvent, mène à l'abandon de l'apprenant. Ainsi, du fait des difficultés rencontrées par le tuteur pour assurer un encadrement et un suivi appropriés à partir des traces de communication (en quantités conséquentes) laissées par les apprenants, nous proposons une approche multi-agents pour analyser les conversations textuelles asynchrones entre apprenants. Ces interactions sont révélatrices de comportements sociaux-animateur, indépendant, etc... qu'il nous paraît important de pouvoir repérer lors d'une pédagogie de projet pour permettre aux apprenants de situer leurs travaux par rapport aux autres apprenants et situer leur groupe par rapport aux autres groupes d'une part, et d'autre part permettre au tuteur d'accompagner les apprenants dans leur processus d'apprentissage, repérer et soutenir les individus en difficulté pour leur éviter l'abandon. Ces indicateurs seront déduits à partir des grands volumes d'échanges textuels entre apprenants.L'approche a été ensuite testée sur une situation réelle, qui a montré une parfaite concordance entre les résultatsobservés par des tuteurs humains et ceux déterminés automatiquement par notre système
The growing importance of online training has put emphasis on the role of remote tutoring. A whole new area of research, dedicated to environment for human learning (EHL), is emerging. We are concerned with this field. More specifically, we will focus on the monitoring of learners.The instrumentation and observation of learners activities by exploiting interaction traces in the EHL and the development of indicators can help tutors to monitor activities of learners and support them in their collaborative learning process. Indeed, in a learning situation, the teacher needs to observe the behavior of learners in order to build an idea about their involvement, preferences and learning styles so that he can adapt the proposed activities. As part of the automatic analysis of collaborative learner¿s activities, we describe a multi agent approach for supporting learning activities in a Virtual Learning Environment context. In order to assist teachers who monitor learning processes, viewed as a specific type of collaboration, the proposed system estimates a behavioral (sociological) profile for each student. This estimation is based on automatic analysis of students textual asynchronous conversations. The determined profiles are proposed to the teacher and may provide assistance toteacher during tutoring tasks. The system was experimented with students of the master "software quality" of the Ibn Tofail University. The results obtained show that the proposed approach is effective and gives satisfactory results

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Le, Clerc Sigrid. "Analyses 'genome entier' de la cohorte griv de patients à profil extrême du sida." Phd thesis, Conservatoire national des arts et metiers - CNAM, 2010. http://tel.archives-ouvertes.fr/tel-00592265.

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Après 25 ans de recherche intensive, aucun vaccin ou traitement définitif contre le SIDA n'existe, et les mécanismes moléculaires de pathogenèse de l'infection VIH-1 ne sont pas clairement élucidés. Les avancées technologiques permettent de comparer des sujets malades avec des sujets contrôles sur tout le génome. Il est ainsi possible d'identifier sans a priori des gènes potentiellement impliqués dans le développement de la maladie avec pour conséquence le développement rationnel de nouvelles stratégies diagnostiques ou thérapeutiques. Durant ma thèse, j'ai réalisé deux études d'association 'génome entier' dans le SIDA, en comparant les 275 non-progresseurs à long terme ou les 85 progresseurs rapides de la cohorte GRIV avec une cohorte de contrôles séronégatifs. J'ai réalisé une troisième analyse en exploitant les données issues de trois études 'génome entier' internationales dont la nôtre (France, Pays-Bas, USA), ciblant plus particulièrement les SNPs de fréquence faible (fréquence de l'allèle mineur, MAF<5%). Ces approches 'génome entier' ont réaffirmé le rôle central du HLA dans la progression vers le SIDA, mais aussi dévoilé de nouveaux gènes candidats très pertinents donnant une nouvelle lumière sur les mécanismes moléculaires de la maladie.

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Valentine, Thomas Robert. "Illness Perceptions and Psychological and Physical Health Outcomes in Non-Small Cell Lung Cancer: A Self-Regulatory Model Approach." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1594830809190808.

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30

Villeneuve, Claire. "Déterminants et évolution de profils de qualité de vie et d’adhésion aux traitements : analyse dans une cohorte de patients transplantés rénaux." Thesis, Limoges, 2016. http://www.theses.fr/2016LIMO0053/document.

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En parallèle des facteurs cliniques et biologiques, de nombreux déterminants psychologiques, dont l’adhésion et la qualité de vie, peuvent influencer la survie des greffons et des patients transplantés. Dans ce contexte notre objectif était d’étudier l’hétérogénéité des profils d’évolution de la qualité de vie et d’adhésion chez les patients transplantés rénaux et d’en identifier les déterminants. Dans un premier temps, l’étude de la qualité de vie a permis d’identifié deux sous-populations homogènes de patients: une majorité présentaient une qualité de vie semblable à la population générale alors que 40% des patients montraient une qualité de vie dégradée associé à une augmentation d’épisodes d’anxiété et de faiblesse musculaire. Nous avons pu montrer, dans un deuxième temps, qu’il existait deux profils d’évolution de l’adhésion : la majorité des patients étaient adhérents alors que 15 % des patients présentaient une non-adhésion en constante augmentation, une qualité de vie mentale dégradée et de plus nombreux épisodes de dépression. Enfin, nous présentons dans ce travail un nouvel outil dédié à l'évaluation de l’adhésion aux immunosuppresseurs des patients transplantés francophones. Cette thèse fournit de nouveaux outils, facile à utiliser précocement ou à distance de la greffe, permettant de détecter les patients présentant une qualité de vie et/ou une adhésion dégradée afin de mettre en place, pour ces patients, une prise en charge personnalisée
In parallel to clinical and biological factors, many psychological determinants could influence transplant patient grafts survival and contributes to patients’ morbidity and mortality. Among them, adherence and quality of life were largely reported. In this context, our objective was to study, in kidney transplant patients, quality of life and adherence time-profiles heterogeneity and to identify determinants of distinct time-course. First, we identified two homogeneous subpopulations of patients: a majority presented a quality of life similar to the general population, while 40% of patients showed a poor quality of life associated with more episodes of anxiety and muscle weakness. Secondly, we found two distinct adherence time-profiles: the majority of patients were adherent while 15% presented a non-adherence constantly increasing associated with a poor mental quality of life and more depressive episodes. Finally, we proposed in this work a new tool dedicated to the evaluation of adherence in French-speaking transplant patients. This thesis provides new tools, easy to use even early on after transplantation, to detect patients with poor quality of life and / or adhesion in order to individualize the management of these patients with appropriate interventions

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Palazzo, Alessandra Bugatte 1981. "Avanços no estudo de edulcorantes em chocolates tipo ao leite , light em calorias e isentos de lactose e sacarose = perfil sensorial descritivo, tempo-intensidade múltiplo e vida útil = Advances in the study on chocolate milk sweeteners, light of calories, free of lactose and sucrose : sensory descriptive profile, multiple time-intensity and shelf-life." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254243.

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Orientador: Helena Maria Andre Bolini
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
Made available in DSpace on 2018-08-22T21:24:46Z (GMT). No. of bitstreams: 1 Palazzo_AlessandraBugatte_D.pdf: 3757920 bytes, checksum: c5aacf04a4c0054e8161cba577ed32e0 (MD5) Previous issue date: 2013
Resumo: Mundialmente a exigência por dietas controladas tem crescido vertiginosamente. Entre elas, destacam-se alimentação com redução calórica, restrição de açúcares, gorduras e sódio, almejando a prevenção de doenças e tratamento de certas deficiências. Em função dessa demanda do mercado, aliada a políticas de incentivo ao avanço tecnológico, buscou-se um alimento que atendesse a essas necessidades. Nesse contexto, verificou-se também a expansão do mercado interno de chocolates, a qual destaca aumento de 14% no consumo de chocolates entre 2009 e 2010, fomentando competitividade e necessidade de inovação neste segmento. Diante disso, o presente projeto visou formular diferentes chocolates dietéticos isentos de lactose, produzidos à base de extrato proteico de soja, utilizando três distintos edulcorantes em substituição à sacarose. Além disso, os mesmos edulcorantes foram incorporados a massas de chocolates ao leite, garantindo dessa forma, um comparativo entre as amostras. Os edulcorantes analisados foram sucralose, rebaudiosídeo e neotame, juntamente com polidextrose e eritritol, como agentes de corpo e agregaores de doçura. As doçuras equivalentes foram determinadas através da análise tempo-intensidade para gosto doce. Visando a caracterização dos produtos formulados foram realizados dois testes sensoriais descritivos. Conduziu-se uma Análise Descritiva Quantitativa com equipe treinada composta de 11 provadores, os quais avaliaram 17 termos descritores durante sessões individuais de análise. No teste tempo-intensidade foram abordados os atributos considerados mais relevantes para análise de chocolate em função do tempo, como os gostos doce e amargo, sabor de chocolate e derretimento na boca. Paralelamente a avaliação afetiva foi conduzida através de teste de aceitação com, no mínimo, 112 consumidores potenciais de chocolates. Os parâmetros relacionados ao processamento dos chocolates também foram controlados, como tamanho máximo de partículas durante o refino da massa e índice de temperagem. Após oito horas de conchagem e resfriamento controlado, os chocolates foram avaliados quanto à viscosidade e textura instrumental. Consolidando a caracterização do produto foi elaborado um estudo de vida útil durante o período de 12 meses, o qual os chocolates permanecerem armazenados em câmara à 23ºC. Dessa forma, justifica-se o estudo voltado ao chocolate, produto este altamente comercializado e apreciado mundialmente por consumidores de diferentes faixas etárias. Através da análise de tempo-intensidade para doçura equivalente, determinaram-se as concentrações dos edulcorantes, sendo 0,075% de sucralose, 0,0215% de rebaudiosídeo, 0,005% de neotame, 17% de polidextrose e 26% de eritritol. Durante a ADQ, os provadores descreveram todos os chocolates semelhantes em relação ao aroma de cacau e aroma de manteiga de cacau. Os resultados de aceitabilidade para os chocolates de soja apontaram aceitação pelos consumidores até 6 meses de estocagem. Ao contrário disso, os chocolates ao leite permaneceram com valores de aceitação entre 4,8 a 6,0 (considerando a escala de 9 pontos) no prazo final de 12 meses de estudo. A sucralose demonstrou semelhança sensorial em relação ao controle, visando à substituição integral da sacarose, evidenciada pela ADQ, tempo-intensidade múltipla e aceitação. Atributos como brilho e homogeneidade contribuíram positivamente na aceitação dos chocolates, verificada pela correlação dos Quadrados Mínimos Parciais entre os chocolates ao leite e de soja em relação aos atributos da ADQ e impressão global do teste de aceitação. Em contrapartida, tem-se aroma de manteiga de cacau como parâmetro que contribui de forma negativa à aceitabilidade pelos consumidores. A redução calórica calculada em torno de 28% em relação a todos os chocolates formulados reforçou a denominação light/diet destes alimentos destinados ao público em questão. Conclui-se assim, que indivíduos que apresentem alterações metabólicas como intolerância à lactose ou diabetes, além de alergias relacionadas às proteínas lácteas, podem ser beneficiados com essas opções de chocolates
Abstract: Worldwide the demand for controlled diets has grown dramatically. Among them, calorie reduction, restriction of sugar, reduction of fat and sodium, targeting disease prevention and treatment of certain deficiencies. According to this market demand, combined with politics to encourage technological advancement, we searched for a food that meets those needs. In this context the expansion of the internal market of chocolates, with 14% of increase in chocolate consumption between 2009 and 2010, together with competitiveness and requeriments for segment¿s innovation. Therefore, the objetive of this project is to formulate different diet lactose free chocolates, produced based on soy protein extract, using four different sweeteners to replace sucrose. Furthermore, the same sweeteners are incorporated in the milk chocolates mass, thereby ensuring a comparison between the samples. The sweeteners analyzed were sucralose, rebaudioside and neotame, and polydextrose and erithritol as bulk agents. The sweetness equivalent was determined by time-intensity analysis for sweet taste. Two descriptive sensory tests were conduced to characterize the formulated products. A Quantitative Descriptive Analysis was done with 11 trained painel, who rated 17 parameters during individual sessions to analyze and describe all the chocolates similar regarding the cocoa flavor and aroma of cocoa butter. The time-intensity analysis have been conduced with the most important attributes for chocolate analysis of time, such as tastes sweet and bitter, chocolate flavor and melting in the mouth. Both an affective evaluation was conducted through the acceptance test with at least 112 potential consumers of chocolates. The processing parameters of chocolates were also controlled, as medium particle size during the refining mass and index value of tempering. After eight hours of conching and controlled cooling, the chocolate were evaluated for viscosity and texture analysis. Complementing the characterization of the product, a study of shelf life was done during 12 months, which the chocolates were stored in the camera 23ºC. The objective of this study was justified considering that chocolate are marketed and highly appreciated worldwide for consumers of different age groups. Through multiple time-intensity for sweet taste, sweetners concentrations were determined, 0,075% to sucralose, 0,0215% to rebaudioside, 0,005% to neotame, 17% to polydextrose and 26% to erithritol. The results of acceptability for chocolate soy showed consumer acceptance until six months of storage. In contrast, the milk chocolates remained with acceptance values between 4,8 to 6,0 (considering 9-point scale) on the deadline of 12 months of study. Sucralose showed similar sensory compared to control, aiming at the replacement of the sucrose, as evidenced by the QDA, multiple time-intensity and acceptance. Attributes as brigthness and homogeneity have positively contributed for chocolate acceptance, realized in Partial Least Square between milk and soy chocolates, QDA attributes and global feeling to acceptance test. On the other hand, cocoa butter aroma as attribute that contributed with negative form to accetpance by consumers. The calculated caloric reduction of around 28% on all chocolates formulated claim the denomination light / diet of these foods to the public in question. Thus, individuals who have metabolic disorders such as lactose intolerance or diabetes, plus related allergies to milk proteins may benefit from these options of chocolate products
Doutorado
Consumo e Qualidade de Alimentos
Doutor em Alimentos e Nutrição

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Aboualmal, Abdulhadi M. A. "Analysis and modelling of the impact of anomalous propagation on terrestrial microwave links in a subtropical region, based on long-term measurements : statistical analysis of long-term meteorological and signal strength measurements in a subtropical region and investigation of the impact of anomalous refractivity profiles on radio propagation in terrestrial microwave wireless systems." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14804.

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Prevailing propagation phenomena in certain areas play a vital role in deciding terrestrial wireless systems performance. Vertical refractivity profile below 1 km is a critical parameter for designing reliable systems; noting that there is a shortage of upper-air data worldwide. Anomalous phenomena may cause severe signal fading and interference beyond the horizon. The objectives of this thesis are to investigate dominant refractive conditions in the subtropical Arabian Gulf region, develop new approaches and empirical models for evaluating vertical refractivity profiles and relevant propagation parameters in the low troposphere, and to examine the impact of frequently experienced anomalous phenomena on terrestrial microwave links. Twenty-three years of meteorological measurements, from 1990 to 2013, are utilized using spatially separated surface stations and a single radiosonde in the United Arab Emirates (UAE). Profiles of sea level, surface and upper refractivity components are statistically analysed. Three major atmospheric layers; namely 65 m, 100 m and 1 km above the ground are studied to analyse relevant propagation parameters such as sub-refraction, super-refraction, anomalous propagation probability parameter β0 and point refractivity gradient not exceeded for 1% of time. The effective earth radius factor k is investigated using a new weighted averaged approach. In addition, the seasonal structure of atmospheric ducting is dimensioned within 350 m layer above ground. Finally, microwave measurement campaign is conducted using multiple radio links operating in UAE using various frequency bands. The link budget simulations are compared with the signal strength measurements. Fading scenarios are studied against the observed anomalous conditions and several recommendations are concluded.

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BATTAGLIA, Giuseppe. "NOVEL TOOLS FOR THE MECHANICAL ANALYSIS OF THIN PLATES AND RELEVANCE ON MEMBRANE-BASED TECHNOLOGIES." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395417.

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Rocha, Michele Roberta. "Análise do perfil empreendedor de Lair Antonio de Souza: um estudo de caso no Laticínio Xandô." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/74/74134/tde-14062017-103356/.

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O presente estudo aborda uma análise de fundamentação teórica a partir de um estudo de caso, com base no perfil empreendedor de um agente do agronegócio do setor leiteiro: Lair Antonio de Souza. Ele foi o fundador da marca de Laticínio Xandô, no ano de 1982, em Araras/SP embora sua trajetória empreendedora tenha começado bem antes. O trabalho atual objetiva contribuir para o estudo comportamental do empreendedorismo, enquanto se propõe a aprofundar aspectos envolvidos na construção e consolidação do perfil empreendedor do principal responsável pela história de sucesso da marca Xandô. A metodologia proposta permite a realização de pesquisa qualitativa e exploratória, parte apoiada em entrevistas semi-estruturadas aplicadas junto aos diferentes tipos de atores que conheceram e interagiram com o empresário Lair Antonio de Souza no passado e parte apoiada em pesquisa de entrevistas concedidas por ele em diferentes mídias e de depoimentos de familiares e funcionários. Como base metodológica para o tratamento das informações será utilizada a técnica de análise de discurso. Extrai-se dos resultados de que a forma com que o empreendedor enxergava o trabalho, como componente de sua cultura e visão de mundo, é tida por todos como a \"pedra fundamental\" de sua trajetória de sucesso. Na análise da história de vida deste empreendedor, busca-se entender como se deu a combinação de habilidades de liderança, inovação, articulação, assunção de riscos e de captura de oportunidades frente aos desafios que contextualizam, histórica, econômica e socialmente, o empreendimento na área de produção e comercialização de uma das mais antigas e relevantes marcas de leite tipo A no país.
An analysis of a case is adopted in this study - based on the entrepreneurial profile of an agent in the agribusiness, more specifically, in the dairy sector: Lair Antonio de Souza, founder of Xandô dairy brand in 1982 in Araras / SP (even though his entrepreneurial trajectory had begun a lot earlier). The results to be achieved aim to contribute to the study of entrepreneurship and deepen aspects involved in building and consolidating the entrepreneurial profile of the main responsible for the story of success related to Xandô brand as well. The proposed methodology allows the accomplishment of a qualitative and exploratory research supported by semi-structured interviews with the different types of actors who knew and interacted with the entrepreneur (Lair Antonio de Souza) in the past. Some interviews he gave to different media together with accounts provided by family members and employees were also taken into consideration in our research. As a methodological basis for the processing of the information the discourse analysis technique will be used. We conclude that the way the entrepreneur considered the activities related to the operation was a component of his culture and world view, and as such viewed as the \"cornerstone\" of his trajectory of success. Through the analysis of this entrepreneur\'s history of life we attempt to understand how the combination of abilities such as leadership, innovation, articulation, risk-taking, and the capture of opportunities in the face of challenges (which contextualize historically, economically and socially the entrepreneurship related to the production and commercialization of one of the oldest and most relevant brands of type \'A\' milk in the country) took place.

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Mokoena, Temeki Daniel. "A critical analysis of community-driven development projects aimed at poverty alleviation in Evaton West / by Temeki Daniel Mokoena." Thesis, North-West University, 2004. http://hdl.handle.net/10394/2416.

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Cave, Christine. "Living with One Foot in the Grave: the elderly in Early Anglo-Saxon England." Phd thesis, Canberra, ACT : The Australian National University, 2017. http://hdl.handle.net/1885/144492.

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Although historical documents and texts tell us otherwise, it is generally believed, not only by people without the expertise to know better, that nobody lived to what we would consider to be old age in the distant past. While it is certainly true that fewer individuals reached their allotted three score years and ten, most communities would have had people who lived to their seventies, eighties or even nineties. It is not that the elderly didn’t exist, it is that the methods used to identify and age people in the past, combined with current attitudes, have rendered them invisible. This thesis seeks to examine the implications on life, both social and physical, of living to old age in Early Anglo-Saxon England. To do this, elderly individuals first need to be made visible and identified. For this purpose then, an approach that identifies the invisible elderly in a cemetery context is proposed, illustrated with an Anglo-Saxon cemetery example. Subsequently, the elderly in three Early Anglo-Saxon cemeteries are examined: Great Chesterford, Essex; Mill Hill, Deal, Kent; Worthy Park, Kingsworthy, Hampshire. The graves of the individuals buried in these cemeteries, their grave goods and their skeletal remains are discussed and elderly people are compared to those younger to determine whether old age increased their relative status, decreased it, or whether it remained the same. Whether sex or its close relative gender had an effect on these determinations is also explored. A case study involving two elderly women concludes this thesis. In general, it is found that while the elderly are not a homogenous group, some evidence for respect is found, as well as some lesser treatment, and that the elderly are treated similarly in death to younger cohorts. In contrast, when examined through the lens of sex, it was found that males, fewer of whom reach the oldest age categories, tend to increase their status with age, while the status of females appears to decline from about the age of about thirty. The two women in the case study, who were given somewhat less than average burial treatment, may have been the last pagans in the community.

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Mounier, Anaïs. "Analyses post-génomiques : étude de l'implication d'IL-33 et de BIN1 dans la physiopathologie de la maladie d'Alzheimer." Phd thesis, Université du Droit et de la Santé - Lille II, 2013. http://tel.archives-ouvertes.fr/tel-00966351.

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Les analyses génomiques ont permis d'identifier des gènes et des protéinesimpliqués dans la maladie d'Alzheimer (MA). Au laboratoire, des approchesdifférentes ont mis en évidence deux gènes différentiellement exprimés dans lamaladie : le gène IL-33, retrouvé comme étant sous-exprimé chez les patientsatteints de MA, et le gène BIN1, identifié par des approches de GWAS et retrouvécomme étant sur-exprimés dans le cerveau des patients.Nous avons observé que la protéine IL-33 avait un impact sur le métabolismedu précurseur du peptide amyloïde (APP) de par sa fonction de facteur de régulationtranscriptionnelle. Nous avons alors cherché à identifier les gènes modulés par IL-33ainsi que des sites potentiels de fixation de la protéine sur l'ADN par des analyses àhaut débit. Il a été observé qu'IL-33 avait une forte implication dans la transcriptiondes gènes et pouvait agir directement sur l'ADN de par son impact sur les histones.De plus, IL-33 augmenterait l'expression de la préséniline 2, ce qui expliquerait alorsson impact sur le métabolisme de l'APP.Nous avons identifié un polymorphisme fonctionnel dans la région régulatricedu gène BIN1 associé à la maladie et pouvant expliquer la variation de sonexpression retrouvée dans le cerveau des patients. Nous avons également retrouvéune interaction de la protéine BIN1 avec Tau. BIN1 est alors le premier déterminantgénétique de la MA retrouvé comme étant associé à Tau et pourrait expliquer le lienentre la pathologie amyloïde et la pathologie Tau.Nos analyses nous ont donc permis, à partir des résultats d'analysesgénomiques, de mieux comprendre les mécanismes impliqués dans laphysiopathologie de la MA.

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Strothmann, Wolfram. "Multi-wavelength laser line profile sensing for agricultural applications." Doctoral thesis, 2016. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2016110315110.

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This dissertation elaborates on the novel sensing approach of multi-wavelength laser line profiling (MWLP). It is a novel sensor concept that expands on the well-known and broadly adopted laser line profile sensing concept for triangulation-based range imaging. Thereby, the MWLP concept does not just use one line laser but multiple line lasers at different wavelengths scanned by a single monochrome imager. Moreover, it collects not only the 3D distance values but also reflection intensity and backscattering of the laser lines are evaluated. The system collects spectrally selective image-based data in an active manner. Thus, it can be geared toward an application-specific wavelength configuration by mounting a set of lasers of the required wavelengths. Consequently, with this system image-based 3D range data can be collected along with reflection intensity and backscattering data at multiple, selectable wavelengths using just a single monochrome image sensor. Starting from a basic draft of the idea, the approach was realized in terms of hardware and software design and implementation. The approach was shown to be feasible and the prototype performed well as compared with other state-of-the-art sensor systems. The sensor raw data can be visualized and accessed as overlayed distance images, point clouds or mesh. Further, for selected example applications it was demonstrated that the sensor data gathered by the system can serve as descriptive input for real world agricultural classification problems. The sensor data was classified in a pixel-based manner. This allows very flexible, quick and easy adaptation of the classification toward new field situations.

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Chen, Chien-Feng, and 陳建鋒. "The relationship between FH-E line angle and Chinese beauty profile: silhouette, photometric analysis and clinical application." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/c45r8x.

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碩士
國防醫學院
牙醫科學研究所
107
Objectives The pursuit of beauty and charm has forever been an aim of human beings, but “beauty” is difficult to define. This study investigated the relationship between the Frankfort horizontal plane- aesthetic line (FH–E line) angle and the Chinese beauty profile. Materials and methods We altered the incline of the E-line of silhouettes using Photoshop 6.0 and used a questionnaire to ask 322 laypersons to select a favorite profile. We also collected 66 photographs of the 10 most popular male and female Chinese celebrities for 2010–2018 from the network and measured the angle of the FH plane and E-line. Retrospective analysis was performed to assess the change of the FH–E line angle of 15 orthognathic surgery patients and the results were compared with the celebrities. Results The FH–E line angle of the favorite silhouette identified in the questionnaire is 50° for women and 60° for men. The mean and range values of the FH–E line angle are sequentially 59.39° ± 3.97° (range 51°–67°) for female stars and 60.67° ± 4.06° (range 53°–70°) for male stars. The average preoperative FH–E line angle in female and male patients was 68.0° ± 3.56° and 68.33° ± 1.70°, respectively, and the postoperative average angle for female and male patients was 61.58° ± 3.87° and 62.33° ± 1.70°, respectively. Apply the results to clinical practice in 3D surgical simulation. Conclusions A similar FH–E line angle was found by comparing the postoperative orthognathic surgery patients and famous movie stars through photographic analysis. The FH–E line angle could be a major reference angle in Chinese populations.

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Li, Li. "Deformation Study of Nanocrystalline Ni-Fe Alloy using Synchrotron Diffraction." 2010. http://trace.tennessee.edu/utk_graddiss/820.

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This dissertation addresses two critical issues in the deformation of nc metals and alloys: (1) A stress-induced genuine grain growth after the plastic deformation rather than just a change of the grain shape; (2) A systematically quantitative study of micrsostructural evolution during the plastic deformation. These two critical issues point to the deformation of nc materials with the average-grain sizes within the range of 10 to 50 nm, which is the most interesting and controversial region in the current time. The current study provides a systematic and detailed microstructural evolution for this region, which is definitely beneficial for the investigation of the deformation mechanism in this region, especially for the simulation. The main experimental and data-analysis methods employed in this research are synchrotron high-energy X-ray diffraction, X-ray line profile analysis, and texture analysis. The combination of these methods is beneficial to the accurate microstructural interpretation of the bulk materials.

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Arunachalam, Subbiah. "Life Sciences Research in India: A Profile Based on Biosis 1998." 2001. http://hdl.handle.net/10150/105873.

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Life sciences research in India is mapped based on papers published in 1998 and indexed in Biosis Biological Abstracts. The findings are compared with those of an earlier study covering the years 1992-1994. There were 8352 papers in all, and these were published in more than 1080 journals. About 55% o'f life science papers were published in 75 Indian journals and more than 82% of papers were published in journals of impact factor less than 1.0. The two areas in which the largest numbers of papers were published are Agriculture and Biochemistry and molecular biophysics. While most agriculture papers had appeared in journals of impact factor zero or less than 1.0, many Biochemistry and molecular biophysics papers were published in journals of moderate to high impact factors. There has been a tendency over the years to publish papers in journals of higher impact factor. Close to 59% of papers were published by academic institutions, much less than the 64.5% in 1992-1994. This decline in research in academic institutions needs to be addressed. This report was prepared by the M.S. Swaminathan Research Foundation and was submitted to NISSAT, Department of Scientific & Industrial Research Government of India, New Delhi in November 2001.

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Arunachalam, Subbiah. "Mapping Life Sciences Research in India: A Profile Based on BIOSIS 1992-1994." 1999. http://hdl.handle.net/10150/106200.

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Life sciences research carried out in India, as seen from the journal literature indexed in three years of BIOSIS Biological Abstracts (1992-1994), is quantified and mapped. The Indian institutions active in life sciences research, the journals and sub-fields in which they publish their work, and the impact factors of the journals as seen from Journal Citation Reports 1992 and 1994 are identified. In the three years studied researchers from over 1,400 institutions located in over 450 cities/ towns have authored 20,046 papers in 1,582 journals published from 52 countries. Over 54% of these papers have appeared in 18 Indian journals. While India has contributed papers to al 10 sub-fields, her contribution has exceeded 1,000 papers in three years in only four sub-fields, and 500 papers in seven other sub-fields. Only 49 institutions have published more than 100 papers each. The contribution made by different institutions to 26 sub-fields and to 36 often used journals is highlighted. More than 64% of Indian papers indexed in BIOSIS come from academic institutions. Among scientific agencies, Indian Council of Agricultural Research and Council of Scientific and Industrial Research have published more than 1,500 papers each. In all Indian researchers have published 188 papers (less than 1.0%) in journals with a 1994 impact factor greater than 4.0. More than 46.3% of Indian papers have appeared in non-5CY journals, and a further 37.5% of papers have been published in journals with impact factors less than 1.0. The analysis reveals the existence of two clusters: a large number of institutions devoted to agriculture and classical biology, publishing mostly in low-impact journals, often in Indian journals, and a smaller group of institutions publishing some papers in new biology and some areas of medicine in quality international journals of medium impact. The larger cluster includes the agricultural universities and many general universities, while the smaller cluster includes the Indian Institute of Science, All India Institute of Medical Sciences, Centre for Cellular and Molecular Biology, National Institute of Immunology, and Indian Institute of Chemical Biology. While it would be desirable for Indian researchers to publish bulk of the agricultural research and a substantial part of medical research in Indian journals, they have no such constraint in new biology and can publish their work in high-impact international journals. Yet only a small proportion of Indian papers in biochemistry and molecular biology, general and internal medicine, microbiology, biophysics, immunology, and gastroenterology have appeared in such journals.

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CHEN, YEN-PENG, and 陳彥鵬. "A Meta-Analysis on the Effects of Empirical Studies Using Life Attitudes Profile." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/28002055461211469012.

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碩士
中國文化大學
心理輔導學系
104
The purpose of this research aims to investigate the effectiveness of the dependent variable and criterion variable in empirical research (including experimental research and correlation research) by using life attitude profile as measuring tools. Based on the purpose of this research, a total of 47 experimental research literatures were chosen using literature retrieval system. In accordance with the research method (Meta-analysis), 42 research literatures were screening out to be used in this research which categorised into experimental research (18 comparison numbers) and correlation research (39 comparison numbers). Fixed effect model was used in investigating the total effect size in experimental research literature while the random effect model was used for correlation analysis literature. In addition, both experimental research literature and correlation analysis of literatures were investigated to explore the sub scale effect size and variable adjustment. The findings are as follows: 1. The effect size of life attitude profile using in the life education program research is 0.471, which were below the average. The effect size from the tracking test is below the average at approximately 0.446. 2. The effect size of the life attitude profile subscale effect size using in the experimental research as follows, 1) Will to meaning, 0.413 (2) Existential Vacuum, 0.322 (3) Life purpose, 0.288 (4) Life control, 0.323 (5)Suffer acceptance, 0.269 (6)death acceptance, 0.314. It shown that all the subscale effect result are below the average. 3. The effect size of the prediction on types of psychology and demand criterion variables using life attitude profile in correlation research is 0.488, the strength of association were approaching to the moderate range. The effect size of the cognition and belief variables is 0.279, the strength of association were below the average. The effect size of the social and behavioral criterion variable is 0.473, the strength of association were approaching to the moderate range. It indicated that the life attitude profile is better to be used in measuring the strength of association of the effect size of the prediction on types of psychology and demand criterion variables, the effect size of social and behavioural criterion variable than measuring strength of association of the effect size of the cognition and belief using the life attitude profile. 4. The effect size of the total scale on life attitude profile using in the correlation research is 0.430, the strength of association is below the average. 5. The effect size in the correlation research using the life attitude profile subscale effect size as follows, (1) Will to meaning, 0.338 (2) Existential Vacuum, 0.395 (3) Life purpose, 0.338 (4) Life control, 0.302 (5)Suffer acceptance, 0.270 (6)death acceptance, 0.275. It shown that all the subscale effect result are below the average. 6. There are a total of 4 variables that have impact on the use of life attitude profile in experimental research, as follows: publishing style, subject groups,subscale deletion, publication style and statistics method. It indicated that the effectiveness of the experimental research is affected by the 4 different variables. 7. Criterion variable is the only variable that have impact on the use of life attitude profile in correlation research. It indicated that criterion variable is main factor affect the strength of association. 8. In conclusion, the average effect size of the life attitude profile using in either experimental research or correlation research are approaching to 0.5. It demonstrated that life attitude profile achieved a great result in measuring the meaning of life. A number of general comments and suggestions are offered for future research in the findings and conclusion above.

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44

Santos, Francisco José Furtado. "Studying prostate cancer cell lines metabolome with FTIR spectroscopy." Master's thesis, 2018. http://hdl.handle.net/10773/24218.

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Cancer is one of the leading causes of death worldwide, with prostate cancer being the second most common neoplasia amongst men. Thus, strategies that can provide an early diagnosis of this disease are of great importance. Because biochemical alterations precede morphological changes in cells, cancer metabolome has gained relevance and may contribute to the understanding of tumor biology and to the identification of early diagnostic biomarkers. Fourier-transform infrared (FTIR) spectroscopy is a metabolomics technique that, unlike staining procedures and other histopathologic approaches, is rapid, non-destructive and does not require reagents. This technique probes the biochemical composition of the analyzed samples and allows the discrimination of samples with distinct metabolic profiles, thus discriminating cancerous and non-cancerous samples. The main goals of this work were to explore the ability of FTIR spectroscopy, coupled with multivariate analysis, in the: (1) discrimination between prostate cancer cells derived from a primary tumor (22Rv1) and normal epithelial cells (PNT1A and PNT2); and (2) discrimination between prostate primary tumor cells (22Rv1) from metastatic cells derived from two distinct sites (LNCaP, from lymph node, and PC-3, from bone). A clear discrimination between the different prostate cell lines was observed, indicating that they exhibit different metabolic profiles. This discrimination can be attributed to an altered lipid metabolism (3000-2800 cm-1, 1800-1700 cm-1 and 1500-1400 cm-1) and the presence of protein aggregates (1622 cm-1). Our results suggest that studying cancer metabolome with FTIR spectroscopy not only allows the understanding of tumor pathogenesis, but also may be a valuable tool for the identification of early diagnostic biomarkers, which are crucial for a good prognosis.
O cancro é uma das principais causas de morte no mundo, sendo o cancro da próstata o segundo mais comum nos homens. Por isso, o desenvolvimento de estratégias que possam fornecer um diagnóstico precoce é de extrema relevância. Uma vez que as alterações bioquímicas precedem as modificações morfológicas nas células, o estudo do metaboloma do cancro tem ganhado relevância e poderá contribuir para a compreensão da biologia do cancro e identificação de biomarcadores de diagnóstico precoce. A espectroscopia de infravermelho, em particular por FTIR, é uma técnica de metabolómica que, ao contrário de procedimentos histopatológicos, é rápida, não destrutiva e não requer o uso de reagentes. Esta técnica é capaz de detetar a composição bioquímica das amostras e permite a distinção de amostras com perfis metabólicos distintos, possibilitando, assim, a discriminação de células tumorais e normais. Os principais objetivos deste estudo foram explorar a capacidade do FTIR, acoplado a análise multivariada, na: (1) discriminação entre células de tumor primário de próstata (22Rv1) e células epiteliais normais (PNT1A e PNT2); e (2) discriminação entre células de tumor primário e células provenientes de metástases (LNCaP, de nódulo linfático, e PC-3, de osso). Através da análise por PCA observou-se uma discriminação entre as diferentes linhas celulares, sugerindo que possuem diferentes perfis metabólicos. A separação entre as diferentes células pode ser atribuída a alterações no metabolismo lipídico (3000-2800 cm-1, 1800-1700 cm-1 and 1500-1400 cm-1) e à presença de agregados proteicos (1622 cm-1). Os nossos resultados sugerem que o estudo do metaboloma do cancro, por FTIR, não só permite a compreensão da patogénese tumoral, como também poderá contribuir para a identificação de biomarcadores de diagnóstico precoce, que são importantes para um bom prognóstico.
POCI-01-0145-FEDER-016728; PTDC/DTP-DES/6077/2014; POCI-01-0145-FEDER-007628
Mestrado em Biomedicina Molecular

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45

Huang, Shyh-Ming, and 黃識銘. "Life-Style, Consumption Attitude, and Consumption Behavior - A profile Analysis of the Generation Cohort In Taiwan." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/64299606573023336967.

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碩士
元智大學
管理研究所
87
Life-style, Consumption Attitude, and Consumption Behavior -A Profile Analysis of the Generation Cohort In Taiwan This research starts from social issue to localization and combines with lifestyle, value, consumption attitude and behavior to see the whole picture. In order to Taiwan generation cohort type and definition, studies and described, analyze the relationship of consumption attitude, value, and consumption behavior. This research uses secondary data that provided by ICAN Company in 1998 research data. The samples of this study aged from 15-49 and the samples include 30cites in Taiwan. As the same as Yankelovich Monitor, this study uses 1062 samples and error is ±3.0%. This defined aged below 19as Y generation,20-34as X generation,35-49as baby boom. This study discovery the difference between generation cohort in several point of view which not only are the consumption behavior of product purchasing ,product use frequency, multi-media contact but also in value and consumption behavior. However this varies were not been paid much attention in the past. Marketing people use generation varies can reach goal of effective and segmentation. According to the research ,we found that generation cohort can be differentiate into 3 clusters(shared 96.7%),X generation cohort into 4 clusters(shared 93.5%),and B generation cohort into 3 clusters(shared 96.9%). Demographic variables between generation cohort is different, but within the generation cohort of cluster are same. On the contrary, in the generation cohort, there is bigger difference in lifestyle value and consumption attitude. Different cluster will make difference consumption attitude and value . There are differences on product penetration the type of using frequency, and product purchasing behavior among different generation cohorts. In the same generation cohort, the consumption behavior of the product type of using frequency is different as well. So, in regard to the consumption behavior of the product type of using frequency ,while we are make plan, we should not only consider the different phenomena of generation cohort, but also in the same generation cohort clusters. Among the different generation cohort, we should consider the product penetration rate and the difference of purchasing behavior of consumption behavior as well. There is difference on media contacting among three generation cohorts, but in the same generation cohort of different clusters, it is similar media behavior. So, the strategic suggestion on media communication, we should uses the different media strategy among generation cohorts, for the same generation cluster, we suggest to use the same media strategy. In this research, we found that obvious relationship between value and consumption attitude, the obvious relationship happened between consumption attitude and consumption behavior as well. In the media communication, we should have different strategies. For example, the new products developing, we should put most efforts on Y generation cohort. This generation cohort has big affection result on the new things. Marketing strategy for X generation cohort, we suggest to use rational communication, for B generation cohort, we can stress on the importance of healthy. The conclusion for better planning and the delicate market strategy for consumption behavior, we should not only understand the backside of value and consumption attitude, but also considering the beginning thinking of different generation cohorts and the same generation cohort of different cluster.

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46

Chao, Chen-Yen, and 趙偵言. "New Profile Geometric Design, Finite Element Analyses of Contact Stress, Flow Analyses and LIGA-like Fabrication of Roots Type Rotors." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/23040390292444398717.

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碩士
國立高雄應用科技大學
機械與精密工程研究所
99
Nowadays, Roots type rotors are widely used in various industrial applications, such as rotary blower, pump, supercharger, and compressor, etc. The aim of this paper is to present a new profile geometric design of Roots type rotors, the compound profile of driving rotor is consisted of three-segment curves formed by cycloid-circular-cycloid and circular-cycloid-circular. Based on theory of gearing and continuous connected condition for compound curves, the profile of new Roots type rotors are derived. In order to avoid yielding during rotors rotation of micro Roots type pump, the contact stress of rotors for two-lobe, three-lobe and four-lobe were simulated separately by using the finite element analyses software ANSYS/Workbench. Otherwise, the pressure head of new Roots type pump of two-lobe, three-lobe and four-lobe were analyzed separately by using the computational fluid dynamics software FLUENT. From the analyses results of area efficiency and pressure head, it reveals that the proposed new Roots type rotors can provides more better pump efficiency than those of traditional Roots rotors. The new micro Roots type rotors were successfully fabricated by LIGA-like process and nickel70-cobalt30 electroforming process for the purpose of achieving the high aspect ratio new micro Roots type rotors.

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47

Smith, William Mike. "A comparative analysis of selected pastors' personality profiles and their conflict management styles." Thesis, 2003. http://hdl.handle.net/10392/239.

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This dissertation is a comparative analysis of selected pastors' personality profiles and their conflict management styles. As pastors understand their personalities, this will decrease conflict within themselves and with church members. This research presents three theological presuppositions. They are shared and examined by detailed biblical word studies and biblical examples. It was determined that this research presents the unique study of relationship using the DISC personality profile and Speed Leas' "Discover Your Conflict Management Style." Similar studies were examined and critiqued. The study involved 1,532 pastors in East Texas. The correlation coefficient Pearson (r) was utilized to examine relationships of pastors in their relationship of personality profile and conflict management style, along with scatter plots, and the Chi-square. The significance of the study is that there is a relationship between pastors' personalities and their conflict management styles. Pastors who are (D)ominance in personality tend to have a Persuade conflict management style. Pastors who are (I)nfluencing in personality tend to exhibit a Collaborate conflict management style. Pastors who are (S)teadiness in their personality tend toward a Collaborate style of conflict management. Lastly, those pastors who are (C)ompliance in personality tend to have a Persuade conflict management style. The research found that years in the ministry have little or no effect upon pastors' personalities. Those with less than six years experience and those with twenty-one or more years experience tend to be Collaborate in their conflict management style. All other pastors are inclined to be Persuade. Another significant finding of the research is that the more conflict a pastor faces, the more likely he is to be Persuade in his conflict management style. The education of a pastor affected his conflict management style if he obtained a doctoral degree, making him more likely than any other group to be Persuade. The research will be helpful to pastors to better understand who they are and how they respond to conflict. The research can serve as a resource for churches in leadership development. The research can provide valuable information for church pastor search committees. The committee could administer the survey to a prospective pastor, and together they could discuss his personality and conflict management style as it pertains to the needs of that church. The research can serve as a foundation for future research in this area.
This item is only available to students and faculty of the Southern Baptist Theological Seminary. If you are not associated with SBTS, this dissertation may be purchased from http://disexpress.umi.com/dxweb or downloaded through ProQuest's Dissertation and Theses database if your institution subscribes to that service.

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48

Lane, Crystal A. "Investigating the Health Profile and Quality of Life of Adult Marijuana Users in the United States: Analysis of Self-reported NHANES 2007-2010 Data." 2013. http://scholarworks.gsu.edu/iph_theses/311.

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Background: Marijuana is the most widely used illicit substance in the United States. Public approval of marijuana has driven its legalization in twenty states and the District of Columbia for medical use; and, this year alone (2013), two states have legalized recreational use of the drug. Despite the nation’s growing trend towards marijuana acceptance, the evidence regarding the health effects of its use remains vague. This study was designed to evaluate the health profile of marijuana users by determining the association of marijuana use with quality of life, defined in terms of perceived overall health and as self-reported medical conditions. Methods: The 2007-2010 National Health and Nutrition Examination Survey data was used to evaluate the health profile and quality of life of marijuana smokers. Chi-square and one-way ANOVA analyses were respectively used to compare prevalence and mean differences of select characteristics across different categories grouped by marijuana use. Logistic regression analyses were then performed to determine the association between the reported number of unhealthy days or medical conditions and marijuana use in the past month. All analyses were performed with SAS 9.2 software using weighted data, while 95% confidence intervals were used to determine statistical significance. Results: In total, 7716 cases were included in the study analysis. The prevalence of lifetime marijuana use was 59% (N = 3632), while the prevalence of current (past month) marijuana use was 12.6% (N = 861). Current marijuana users differed significantly from never users with respect to age, gender, income-to-poverty ratio, cigarette smoking, and alcohol and drug use. Current marijuana users also reported more unhealthy days per month, but less frequently reported diagnosis of a medical condition. Results of logistic regression analysis demonstrated that after controlling for confounders, there was no significant association between unhealthy days and current marijuana use, but there was an inverse association with reporting 3+ medical conditions and current marijuana use. Conclusions: This study shows that marijuana users are more likely to engage in health risk behaviors, and report lower quality of life when compared to individuals who have never used marijuana. However, after controlling for confounders, marijuana use was not found to be associated with poor health outcomes.

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49

Erdem, Necip Fazil. "Characterization and Comparative Analysis of Gene Expression Profiles of Three Different Human Oral Squamous Carcinoma Cell Lines With Different Invasion and Metastatic Capacities." 2007. http://trace.tennessee.edu/utk_graddiss/162.

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Matrix metalloproteinases (MMP’s) and cathepsins are thought to play key roles in oral squamous cell carcinoma (OSCC) invasion and metastasis. Three OSCC human cell lines, BHY, HN and HSC-3, have been studied based on their reported ability to invade adjacent bone or metastasize to lymph nodes and/or distant organs. The working hypothesis of this study is that OSCC that demonstrate different actions have different proteolytic enzyme and gene expression profiles. Immunocytochemistry and flow cytometry were used to determine the expression levels of certain proteolytic enzymes. Complementary DNA (cDNA) microarray technique was used to determine the gene expression profiles of each of the three OSCC cell lines. The immunocytochemistry and flow cytometry results showed that the BHY cell line expresses MMP- 9 and extracellular matrix metalloproteinase inducer (EMMPRIN). The BHY cell line expressed 139 upregulated genes and 117 downregulated genes. The HN cell line expressed 214 upregulated and 262 downregulated genes. Finally, the HSC-3 cell line expressed 128 upregulated and 117 downregulated genes. There were 13 genes that were upregulated and 83 genes that were downregulated in all three OSCC cell lines. Eight pathways were upregulated and 3 pathways were downregulated in the BHY cell line. In the HN cell line 10 pathways were upregulated and 9 were downregulated. Finally, in the HSC-3 cell line 3 pathways were upregulated and 6 pathways were downregulated. MMP-1, MMP-9 and EMMPRIN appear to play a role in the invasion of OSCC to bone. KIAA, was upregulated in our study in the HN cell line. Upregulation of KIAA may be involved in the late stage of OSSC. PAM gene was the only downregulated gene in the HN cell line. The TM4SF10 gene was downregulated in all three OSCC cell lines. The COL1A2 and COL4A1 genes were upregulated in the HSC-3 cell line and they may cause the lymph node metastasis of OSCC. Based on this study OSCC involves multiple molecular genetic events that take place in many chromosomes and genes. Upregulation of the Jak-STAT signaling pathway may be involved in bone invasion of OSCC. The MAPK signaling pathway was upregulated in all three OSCC cell lines.

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50

Huang, Leiway, and 黃笠崴. "Discovery of a biomarker of oral cancer by MALDI-TOF MS analysis of protein profiles in oral cancer cell lines and cancer tissues." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/19365771391786178597.

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碩士
東海大學
化學系
100
Oral squamous cell carcinoma (OSCC) is a malignant and aggressive tumor which was occurred mostly in smokers, alcoholics, and betel squid chewers. OSCC is one of the top ten causes of death from cancers in Taiwan, therefore, there is an urgent need to develop a method for detecting oral cancer and identifying high risk individuals at the earlier stages. The goal of this study is to optimize experimental conditions for developing an efficient method for detecting the progression of oral cancer. We have extracted total proteins from six oral cancer cell lines, three normal cell lines and eight oral tumor tissues and their matched normal mucosas, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of protein profiles. Cell lines and tissues were homogenized with protein extraction solution, after centrifugation, supernatant were desalted by solid phase extraction using C18 column. The desalted supernatant was analyzed by MALDI-TOF MS, and results demonstrated that the intensity of a protein fragment with molecular weight of 10.9 kD was correlated with progression of oral cancer. We have optimized experimental conditions and discovered a protein biomarker (10.9 kD) of oral cancer. This biomarker can be applied for the development of efficient methods for monitoring the progression of and diagnosis of oral cancer.

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