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Journal articles on the topic "Lion – Therapeutic use"
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Bano, Parween, Sakhitha K. S, and K. Shankar Rao. "VANGA IN AYURVEDA - A LITERARY REVIEW." International Ayurvedic Medical Journal 8, no. 9 (September 23, 2020): 4520–27. http://dx.doi.org/10.46607/iamj3608092020.
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Regarding the use of metals (Dhatu), history observation reveals that India was the first country to start the use of Vanga for various industrial, alchemical and therapeutic purposes. The word Trapu is mentioned regarding Vanga in Veda and Samhita. In Brihatrayi, external and internal use of Vanga is found with ref-erence to ‘Suvarna Samala Pancha Loha’, ‘Bhouma Dravyas’ etc. In Rasa classics, Vanga and its thera-peutic properties have been widely described under Puti Loha the metal which emit obnoxious smell, while they are melting. Rasa scholars mentioned its synonyms like Vanga, Picchata, Shukraloha etc which de-notes its distribution, physical and therapeutic properties. One of the properties of Vanga is Drutdravam i.e. melt at low heat which proves by its low melting point (2320C). On observing various literature, it is seen that in Samhita, only therapeutic use of mentioned. But in Rasashastra, its types, Pharmaceutical pro-cess like Shodhana, Jarana, Marana and use in alchemical and therapeutic purposes are described widely. Much importance has been given to its efficacy and told that ‘as lion destroy the group of elephants, like wise Vanga destroy all types of Meha Roga’. The author of Ayurveda Prakash has indicated that for Prameha Roga (diabetes), Vanga Bhasma is a drug of choice which is also evaluate by various research works on Vanga Bhasma.
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Rollando, Rollando, Warsito Warsito, Masruri Masruri, and Widodo Widodo. "Potential Therapeutic Use of Sterculia quadrifida R.Br and Sterculia foetida Linn.: Review." Asian Journal of Plant Sciences 19, no. 4 (September 15, 2020): 325–34. http://dx.doi.org/10.3923/ajps.2020.325.334.
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Klimek-Szczykutowicz, Szopa, and Ekiert. "Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies." Plants 9, no. 1 (January 17, 2020): 119. http://dx.doi.org/10.3390/plants9010119.
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This review presents important botanical, chemical and pharmacological characteristics of Citrus limon (lemon)—a species with valuable pharmaceutical, cosmetic and culinary (healthy food) properties. A short description of the genus Citrus is followed by information on the chemical composition, metabolomic studies and biological activities of the main raw materials obtained from C. limon (fruit extract, juice, essential oil). The valuable biological activity of C. limon is determined by its high content of phenolic compounds, mainly flavonoids (e.g., diosmin, hesperidin, limocitrin) and phenolic acids (e.g., ferulic, synapic, p-hydroxybenzoic acids). The essential oil is rich in bioactive monoterpenoids such as D-limonene, β-pinene, γ-terpinene. Recently scientifically proven therapeutic activities of C. limon include anti-inflammatory, antimicrobial, anticancer and antiparasitic activities. The review pays particular attention, with references to published scientific research, to the use of C. limon in the food industry and cosmetology. It also addresses the safety of use and potential phototoxicity of the raw materials. Lastly, the review emphasizes the significance of biotechnological studies on C. limon.
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Ishtiyaq, Ahmad, ABRAR ALAM, Javed Inam Siddiqui, and Munawwar Husain Kazmi. "Therapeutic Potential of Widely Used Unani Drug Asl-Us-Soos (Glycyrrhiza glabra Linn.): A Systematic Review." Journal of Drug Delivery and Therapeutics 9, no. 4-s (August 25, 2019): 765–73. http://dx.doi.org/10.22270/jddt.v9i4-s.3318.
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Plants have been one of the important sources of therapeutics or other human health benefits since the beginning of human civilization throughout history. Currently, there is increasing awareness and general acceptability of the use of herbs, as a medicines, health products, pharmaceuticals, food supplements, cosmetics etc. Traditional system of medicine including Ayurveda, Unani, and Siddha etc. contributed in Health care dealing worldwide. The Unani system of medicine (USM) is an age old system of medicine which has a holistic approach to treat various kind of disease; most of the time the drugs mentioned in this system has tremendous effects in chronic disease.
Asl-Us-Soos (Glycyrrhiza glabra Linn), is a widely used herb in USM. Although the review articles on this plant are already published, this review article is presented to comply all the updated information on its therapeutic potency based on phytoconstituents and pharmacological activities and the potency which is described by renowned Unani physicians and scholars. The evidence based studies provides strengthen to the concept of Unani physicians as the Unani physician used and recommended the drug since along. Moreover the evidence based studies indicate that Glycyrrhiza glabra Linn possesses antibacterial, antioxidant, antimalarial, antispasmodic, expectorant, aphrodisiac, antimycobacterial activity, antiinflammatory and anti-hyper glycemic properties. Various other effects like antiulcer, antiviral, antihepatotoxic, antifungal and herpes simplex have also been studies. These results are very encouraging and indicate that this Unani drug can be studies more extensively with a well-planned and systematic scientific preclinical and clinical approach to explore the promising outcome. Further this review gives an account of the current knowledge on the morphological characters, microscopic characters, phytochemistry, and pharmacological actions present in root of Glycyrrhiza glabra along with its actions and therapeutic potential in the perspective of USM.
Keywords: Glycyrrhiza glabra, therapeutic potential, USM
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N, Mishra D., Gomare K. S, and Sheelwant S. V. "GC-MS Analysis and Phytochemical Screening of Indigofera tinctoria (Linn.) Leaf Extract Characterizing its Medicinal Use." International Journal of Ayurvedic Medicine 11, no. 2 (July 3, 2020): 289–99. http://dx.doi.org/10.47552/ijam.v11i2.1540.
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Indigofera tinctoria (Linn.), a perennial shrub belongs to the family Fabaceae (Leguminosae) is well known in Indian system of medicines for its traditional uses. The present study was carried to find out the possible bioactive components in the leaves of this plant in ethanol extract by Gas Chromatography-Mass Spectrometry (GC-MS) analysis and the therapeutic uses of each compound as per PASS and other database. The mass spectra of the extract found compounds that were matched with the National Institute of Standards and Technology (NIST version 5.7.1) library database. The GC-MS study observed different peaks as per retention time and then those peaks were analysed determining presence of 26 phytochemical compounds. The qualitative phytochemical screening done by routine laboratory methods also indicated presence of these bioactive compound groups like alkaloids, flavonoids, tannins and phenols, saponins, glycosides and terpenoids. These 26 compounds are understood to have different therapeutic activities as per in-silico databases, e.g. 2-Acetylamino-3-hydroxy-propionoic acid (glutamic acid) - used as Anti-diarrheal, Antiviral, Antipyretic, Protein synthesis inhibitor, Antidiabetic, Non-steroidal, Anti-inflammatory agent, Antipsoriatic, Antioxidant, Antifungal, Antineoplastic (sarcoma), Antiparasitic, Antibiotic Aminoglycoside-like, Antiseborrheic, Anticataract, Antithyroid, Anticarcinogenic, Antileprosy, Hair growth stimulant, Lipoprotein lipase inhibitor, Dermatologic, Testosterone, Antituberculosic, Antirickettsial, Antianemic, etc. activities. Hence, Indigofera tinctoria is an excellent source of phytocompounds, which help to heal various diseases and health complications in human beings. The use of this plant in traditional methods for the treatment of such diseases appears scientifically relevant as per the therapeutic activity data of its bioactive compounds.
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Mohan, Nayana, V. Meera, J. Soja, and M. S. Latha. "in silico Docking Analysis of Small Molecule Inhibitors from Nyctanthes arbor-tristis against Nipah Virus Infection." Asian Journal of Organic & Medicinal Chemistry 4, no. 4 (2019): 244–47. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p235.
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Nipah virus is a highly pathogenic paramyxovirus belonging to the genus Henipavirus, classified as Biosafety Level 4 (BSL4) agents. The virus causes severe illness characterized by encephalitis or respiratory disease in human. The case-lethality rate of Nipah was reported to be 70 % in India, since year 2001. Despite the high pathogenicity of virus, no therapeutics are currently approved for use in human. But, ribavirin, favipiravir and human mono clonal antibody was found to reduce the intensity in early stage. Medicinal plants serve as a rich source of therapeutically active compounds. Nyctanthus arbortristis Linn or pavizhamalli (Harsinger) is traditionally known to have activity against Nipha virus. In this study, therapeutic activity of phytochemicals arbortristoside A and arbortristoside C present in pavizhamalli plant against Nipha virus target was investigated by computational docking simulation. Computational docking analysis was performed using Schrodinger Suite. The phytochemicals arbortristoside A and arbortristoside C show promising binding affinity with the target Nipah virus than the reference drugs. Results of the study could be advantageous to develop a new lead molecule against Nipah virus infection.
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Sharma, Gaurav Kumar, and Meenakshi Dhanawat. "Effectual qualitative chemical evaluation of Euphorbia neriifolia Linn. by using fluorescence analysis." Journal of Drug Delivery and Therapeutics 9, no. 1-s (February 15, 2019): 44–47. http://dx.doi.org/10.22270/jddt.v9i1-s.2248.
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Objective -Plants contain numerous biologically active compounds, many of these have been shown to exhibit therapeutic and antimicrobial properties and therefore they were in use as antimicrobial drugs in traditional medicines. Euphorbia neriifolia Linn. belongs to the family Euphorbiaceae. Assessment of medication implies affirmation of its personality and assurance of its quality and virtue and recognition of nature of debasement. Throughout the years the nature and level of assessment of rough medications has experienced an efficient changes. Hence, in the present study an attempt has been made for effectual qualitative evaluation of dried powdered leaves and stem of Euphorbia neriifolia Linn. by fluorescence analysis.
Design & Intervention- The dried powdered sample of Euphorbia neriifolia Linn. leaves and stem has been used to perform fluorescence analysis under the visible day light and UV light of short wavelength (254 nm) and long wavelength (365 nm) for their characteristic colour.
Main outcome measures- The ultra violet light creates fluorescence in numerous common items, which don't noticeably fluoresce in sunshine. In the event that the substances themselves are not fluorescent, they may frequently be changed over into fluorescent subordinates or disintegration items by applying diverse reagents. The hues created by these reagents speak to the nearness of dynamic constituents.
Results- The fluorescence character of any powdered character of any powdered medication is exceptionally particular and supportive distinctive highlights for the assurance of a medication.
Conclusion- The dried powder and herbal extracts of Euphorbia neriifolia Linn. leaves and stem showed varied fluorescence character which is an essential parameter for standardization of herbs.
Keywords: Euphorbia neriifolia Linn., Standardization, Fluorescence analysis, Evaluation, Euphorbiaceae.
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Pallie, Mumtaz S., Pathirage K. Perera, Nishantha Kumarasinghe, Menuka Arawwawala, and Charitha L. Goonasekara. "Ethnopharmacological Use and Biological Activities of Tragia involucrata L." Evidence-Based Complementary and Alternative Medicine 2020 (December 15, 2020): 1–17. http://dx.doi.org/10.1155/2020/8848676.
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Plants have been utilized as medicines to treat various ailments since ancient times. Formulations made by plant materials have been used in traditional, complementary, and alternative medicine and remain widespread in both developing and developed countries. In developing countries, traditional medicines are widely practiced due to its accessibility and affordability, while in developed countries, complementary and alternative medicine are widely popular due to the adverse effects of chemical drugs. Tragia involucrata Linn. (family: Euphorbiaceae) is a highly used medicinal plant used in both Sri Lankan and Indian traditional medical systems. Since this plant is a weed, it is being extensively destroyed due to the lack of knowledge regarding the medicinal value of this plant. Hence, the objective of this study was to collect data on the medicinal value of this plant by correlating its scientifically validated biological activities with its ethnopharmacological uses. An attempt was made to gather as much information available regarding the ethnopharmacological uses and scientifically validated biological activities of Tragia involucrata through authentic traditional texts, scientific journals, and other authentic texts regarding medicinal plants. Thus, the review provides an insight to the capability of Tragia involucrata to be used as a monoherbal formulation for diseases pertaining to multiple systems of the body. With all the scientifically validated biological activities and the ethnopharmacological uses, Tragia involucrata may qualify as a potent candidate to be developed into a phytomedicine to be utilized as both a preventive and as a therapeutic agent.
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Gul, Somia, Sabeen Raza, Zaira Rashid, Maria Ayub, and Ghulam Sarwar. "Neuropharmacological screening of Ficus Carica Linn; Fruit for Anxiolytic and Antidepressant Activity." Bangladesh Journal of Medical Science 17, no. 4 (September 19, 2018): 606–11. http://dx.doi.org/10.3329/bjms.v17i4.38323.
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Background: Rutin and polyphenol which are present in ficus carica linn are responsible for anti-depressant and anxiolytics effect.Aims: We have conducted the study to evaluate the anti depressant and anxiolytic effect of ficuscaricalinn on mice and compare its effect with well known prescribed anti depressant and anxiolytic drug alprazolam.Methods: Three groups of mice were marked as Control, Reference and Test. Each group comprise of 5 mice. Control group was on normal diet. Reference group was feeded alprazolam at a dose of 0.5mg/60kg while test group were provided two different dilution of ficuscaricalinn, one dilution is 250mg/ kg/100ml of water and second dilution is 500mg/kg/100ml of water. We used Light/dark box method and Elevated plus maze method to evaluate the anxiolytic effect of ficus carica linn. To determine the anti-depressant effect of ficus carica linn.Results: we was used one method that is Head Dip Method. Results were collected and observed readings and data were clearly indicating the great and pronounced anti depressant and anxiolytic effect of ficus carica linn at a dose of 500mg/kg compare with a widely prescribed drug alprazolam for its anti-depressant and anxiolytic effect.Ficus carica is well known for its numerous biological activities also found to be one of excellent distressing agent. Stress provoking several disorders could be limit by the use of ficus carica fruit in doses 250mg/kg and 500mg/kg. Ficus carica linn as a natural product may prove better therapeutic agent if more study is conducted on it.Conclusion: As this study is confined to the mice, there’s much possibilities to have similar effect in humans but require more work on it.Bangladesh Journal of Medical Science Vol.17(4) 2018 p.606-611
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Onuoha, Chinyere Henrietta, Charity Chinenye Nwachukwu, Ruth Tochukwu Nwachukwu, Chinwe Glory Nwogu Nwogu, Chieme Sunday Chukwudoruo, and Favour Ntite Ujowundu. "Comparative evaluation of proximate composition and anti-sickling potential of Annona muricata Linn seeds and leaves." AROC in Natural Products Research 01, no. 02 (September 14, 2021): 29–35. http://dx.doi.org/10.53858/arocnpr01022935.
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Background: Annona muricata Linn is a notable, well-studied plant of therapeutic value. Based on the abundant pharmacological constituents contained in the understudied plant, it is imperative that the plant parts are investigated for nutritional value and anti-sickling potentials. Sickle cell anaemia (SCA) is an inheritable haematological disorder, caused by an amino acid substitution on the haem protein. The outcomes for SCA are poor health indices and high mortality. Therefore, the use of natural products is necessary and widely promoted in countries with poor health infrastructure. Methods: In this study, A. muricata seeds and leaves were comparatively analysed for the proximate compositions. In addition, aqueous and ethanol extracts of A. muricata seeds and leaves were respectively analysed for anti-sickling potentials with the use of spectrophotometry. Results: Proximate composition of A. muricata seeds and leaves showed that both plant parts contain ash, carbohydrate, fat, fibre, moisture and protein. However, percentage proximate composition of A. muricata seeds was not significantly different from the percentage proximate composition of A. muricata leaves (p ≤ 0.05). From anti-sickling analysis, the aqueous extracts of A. muricata seeds and leaves were observed to inhibit HbSS polymerisation, while the ethanol extracts of A. muricata seeds and leaves showed limitations to the inhibition of HbSS polymerisation. Conclusion: A. muricata seeds and leaves possess potentials as health or nutritional supplements for the management of SCA. Further studies are necessary in order to ascertain efficacy and safety in in vivo models
Dissertations / Theses on the topic "Lion – Therapeutic use"
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Liozon, Corinne. "De la répétition à la figuration : logiques de la construction du lien thérapeuthique dans les troubles autistiques et psychotiques : « Il est une fois… encore une fois… »." Thesis, Lyon 2, 2015. http://www.theses.fr/2015LYO20052/document.
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Ce travail propose d’interroger la constitution du lien thérapeutique avec des enfants présentant des troubles autistiques ou psychotiques. Ces pathologies narcissiques-identitaires considérées comme troubles majeurs de l’intersubjectivité soumettent nos dispositifs de soins à de constants ajustements, pour accueillir ce que ces sujets nous livrent avec insistance, et qui prend la forme de comportement répétitifs. Nous sommes dans une pratique clinique extrême, aux confins du langage qui nous oblige à repenser notre cadre interne, à redéfinir nos postures, pour soutenir un travail de symbolisation. Retirés dans une sensorialité réconfortante ou absorbés dans des activités ritualisées, ces sujets nous engagent psychiquement et corporellement à « trouver-créer » comment leur faire signe pour établir le contact et relancer les processus de réflexivité entravés. La trajectoire vers l’autre, détour essentiel à la subjectivation des éprouvés corporels est à construire. Ce travail est une modélisation de cette trajectoire du retrait devant l’objet à l’attrait pour l’objet. Deux notions sont développées, celle de l’effacement et celle de l’oscillatoire, qui viennent figurer la dynamique de la rencontre, faite de rapprochements et d’éloignements. Les « états de présence » du thérapeute sont un rouage essentiel de ce processus d’attraction, dont l’accomplissement sera « le partage d’affects »This work presents an investigation of the therapeutic relation to children with autistic or psychotic problems. These narcissistic-identity pathologies, considered as a major problem of intersubjectivity, submit our instruments of care to constant adjustment; in order to harvest what these subjects insistently present in the form of repetitive behaviors. We find ourselves in an extreme of clinical practice, at the limits of language, which forces us to reconsider our internal framework and redefine our positions with the aim of supporting a task of symbolization. Withdrawn into a comforting sensoriality or absorbed in ritualized activities, these subjects engage us psychically and corporally to "find-create" how to draw attention so as to establish contact and relaunch the inhibited processes of reflection.The trajectory towards the other, an essential detour towards the subjectivizing of corporeal feelings, is in need of construction. This work models that trajectory from withdrawal before the object to the attraction towards the object. Two concepts are developed, that of erasure and of the oscillatory. They come to fashion the dynamics of interaction, composed of advances and retreats. The "states of presence" of the therapist are an essential cog in the process of attraction, for which attainment becomes "affective sharing"
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Naidoo, Kerusha. "A homoeopathic drug proving of Panthera leo with a subsequent comparison of Lac leoninum." Thesis, 2015. http://hdl.handle.net/10321/1335.
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Submitted in partial compliance with the requirements of the Master’s Degree in Technology: Homoeopathy, Department of Homepathy, Durban University of Technology, Durban, South Africa, 2015.Introduction This study was a double-blind, placebo controlled proving of Panthera leo 30CH (claw of a African lioness); the aim being to determine the effect of this substance induces on healthy persons and in doing do explore the homoeopathic therapeutic potential thereof, in addition a subsequent comparison with the provings of Lac leoninum (milk of a lioness) (Sankaran,1998) (Herrick,1998) was performed. Objectives The primary objective of this proving was to determine the effect that Panthera leo 30 CH on healthy provers so that the therapeutic potential of the substance could be determined. The secondary objective was to compare the Materia medica of Panthera leo with that of Lac leoninum (Herrick, 1998) and Sankaran (1998). Lastly, the third objective was to further develop the homoeopathic Materia medica by adding the remedy picture of Panthera leo. Methodology The drug proving of Panthera leo was conducted as a randomized, exploratory, double blind placebo controlled study. Thirty participants (healthy volunteers) who met the inclusion criteria (Appendix B) participated in the proving, twenty – four were given the verum and the remaining six placebo. Upon obtaining written informed consent the researcher performed a full case history and comprehensive physical examination on each prover before commencement of the proving. A subsequent follow up case history and physical examination at the end of the proving was also performed to establish whether provers had returned to their respective healthy states. The provers took their first dose of the proving remedy at a dosage of 1 dose three times daily for 2 days and recorded all symptoms they experienced in their respective journals according to the guidelines in Appendix C. On completion of the proving, all provers handed in their journals which were then transcribed, assessed and analyzed. An extensive comparison between the proving of Panthera leo and the two provings of Lac leoninum (Herrick, 1998) (Sankaran, 1998) followed. The respective remedies were compared and contrasted with respect to Materia medica and repertory and similarities and differences highlighted. Results A total of 1255 rubrics were obtained of which the mind section of the Materia medica weighed heavily comprising 35 % (435 rubrics) of the proving symptoms, the generals section (11% = 135 rubrics) and head section (9% = 109 rubrics) respectively. Therefore it can be suggested that this remedy’s sphere of action is limited largely to the mind (emotional state) however unique physical indications specifically regarding headaches are also within its sphere of action. Of the total, 1255 rubrics that were obtained only 11% (138 rubrics) where shared with the two other provings of the African lion (Herrick 1998 & Sankaran 1998); as suggested by Naude (2011) one can speculate that these shared symptoms may represent the unique mammalian component of the animal the differences however considerably outweigh the similarities between these provings and for this reason one can conclude that factors in addition to the species of animal from which the remedy is sourced further influence the resultant proving symptoms. Conclusion It can be concluded that Panthera leo 30CH produced clearly observable symptoms in healthy provers who participated in this proving, furthermore there was clear congruency between certain aspects of this proving and that of Herrick and Sankaran however such similarities were limited.
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Khumalo, Nozipho Lindiwe. "Optimisation of the lion (Panthera leo) specific interferon gamma assay for detection of tuberculosis in lions in South Africa." Diss., 2017. http://hdl.handle.net/10500/27011.
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Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB)
which has a diverse host range. The maintenance host of BTB in South
Africa is the African buffalo (Syncerus caffer). It is believed that lions get
infected by feeding on infected buffalo or through wounds. The spread of
the disease amongst lions has raised concern regarding the future of the
animals and the impact on tourism in the country. Diagnoses of
tuberculosis in free ranging wildlife is often dependent on post-mortem
samples due to logistical challenges, the use of the lion specific interferon
gamma release assay as an antemortem test offers a simpler
methodology to testing live animals. The aim was to optimise an already
developed assay by Maas et al.,2012 and to harmonise it with the
Rhinoceros specific interferon gamma assay developed by Morar-Leather
et al 2007. Optimisation of the interferon gamma specific ELISA included:
determination of optimal concentrations for the capture and detection
monoclonal antibodies; optimal concentrations for the conjugate and
evaluation of alternative blocking agents. Different mitogens and
incubation times were evaluated for the stimulation of whole blood as
positive control in the assay. The optimum concentration for coating the
plates with the capture monoclonal antibody was 2 g/ml. An optimum
dilution of 1:5000 was selected for both the biotinylated detection
monoclonal antibody and the streptavidin horseradish peroxidase
conjugate. The assay was optimised using recombinant lion interferon
gamma and the lower detection limit was calculated to be 109 pg/ml.
Phosphate buffered saline with 1% bovine serum albumin was found to be
Chapter 1
© University of South Africa iii
a suitable blocking agent. Native interferon gamma was detected in whole
blood samples from 5 lions and a 24 hour incubation time with PMA and
ionomycin was selected as the optimal mitogen positive control. This
assay system demonstrated good potential as an ante mortem test for the
diagnosis of tuberculosis in lions.
In conclusion, the assay can detect IFN- from supernatants harvested
from whole blood cultures stimulated with specific antigens and mitogensAgriculture and Animal Health
M. Sc. (Agriculture)
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"Treatment of allergic rhinitis using a Chinese herbal formula Shi-Bi-Lin (SBL): animal study, in vitro study and clinical trial." Thesis, 2005. http://library.cuhk.edu.hk/record=b6073981.
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Conclusions. SBL showed its efficacy in treating the animal model of allergic rhinitis. Its mechanisms may be related to its suppressive action on PCA reaction, the production of TXB2 and the expression of eNOS, as well as its modulation of cytokines, including IL-4, IL-6, IL-8, GM-CSF and TNF-alpha, release from mast cells. The clinical trial showed that SBL had more beneficial action on the quality of life, in comparison to the placebo, in the domains of RE and BP. Some symptoms evaluations of PAR patients, including GF, NB and SF were more markedly improved in the SBL group when compared with the placebo group. Furthermore, the use of SBL, with the study dose and treatment period, was safe. However, the accurate efficacy and mechanisms of SBL are largely unknown and need further investigation. (Abstract shortened by UMI.)Introduction. Although great progress in treatment of allergic rhinitis have made in recent years, remarkably increasing prevalence and cost in epidemiology studies strongly suggest the difficulties in the management of allergic rhinitis. Shi-Bi-Lin (SBL) is a formula modified from the traditional Chinese herbal formula Cang-Er-Zi-San (CEZS) and a classic European formula SinupretRTM. CEZS has been used for the treatment of allergic rhinitis for several centuries in East Asia communities, and SinupretRTM has been used in treating paranasal sinusitis and rhinitis widely in Europe for decades. However, its therapeutic mechanisms remain unclear. We examined the efficacy and the possible mechanism of SBL in an animal model of allergic rhinitis and in cell culture study using Human Mast Cell Line (HMC-1) and Peripheral Blood Mononuclear Cells (PBMC). In addition, a clinical trial was conducted to examine its clinical efficacy and safety.
Results. In the animal study, SBL showed a potent effect in relieving the symptoms of nasal obstruction, sneezing and nasal scratching (P<0.05 or P<0.01), but had no convincing effect in decreasing the nasal discharge (P>0.05). In PCA test, IgG1 increased in a modest manner in the SBL-treated group when compared with the sham group (P<0.05 or P<0.01). Eosinophil infiltration and the expression of eNOS in nasal mucosa, but not iNOS, were obviously lower in the SBL treated group (P<0.05 or P<0.01) in comparison to the sham group. The levels of thromboxane B (TXB)2 in the nasal lavage fluid, but not histamine and peptide leukotrienes (p-LTs), showed significantly lower than that of the sham group (P<0.05). In vitro study showed that SBL modulated the cytokines, including interleukin (IL)-4, IL-6, IL-8, Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) and tumor necrosis factor (TNF)-alpha, release from human mast cell line (HMC-1). However, the mRNA expressions of these cytokines were not significantly altered. As the controls, dexamethasone, desloratadine and budesonide had more potently inhibitory effects on cytokines release from HMC-1. The component herbs generally had stimulatory effects on the cytokine release from HMC-1 and variable effects on PBMC. In the clinical trial, a total of 84 patients were recruited in the clinical trial and 77 of them completed the trial. Although no significant differences of each domain between the SBL and placebo groups were detected, findings supported the efficacy of SBL were obtained.
by Zhao Yu.
"July 2005."
Advisers: C. A. Van Hasselt; Ping-Chung Leung; Kong-Sang Woo.
Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0172.
Thesis (Ph.D.)--Chinese University of Hong Kong, 2005.
Includes bibliographical references.
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Abstract in English and Chinese.
School code: 1307.
Books on the topic "Lion – Therapeutic use"
1
Li, Sun, and Zhou Lihua, eds. Lian qi. Taibei Shi: Zhi qing pin dao chu ban you xian gong si, 2008.
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2
Ai lian fang xiang: A journey into the aroma of essential oils. Taibei Shi: Zhi hui shi ye ti, 2000.
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3
Jian kang yang sheng tang bian wei hui, ed. Ming yi jiao ni zu bu dui zheng cong gen zhi: Quan guo 27 wei ming yuan ming yi lian shou da zao. Nanjing: Feng huang chu ban chuan mei gu fen you xian gong si, 2014.
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Qing xu pai du: 50 zu hu xi shen zhan lian xi, shu tong ren ti qi da bu wei, zhao hui zi xin xin, an quan gan, xing dong li. Taibei Shi: Cai shi chu ban ji tuan, 2017.
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Sŏ, Chae-gŏl. Chi yi kou jiang huang, da kai shen ti zi yu li: Tian ran de zui jia kang sheng su, yi tian chi san ci, Han'guo ming yi yi lian chi ba nian, xiao guo you ru bu bi dong de you yang. Taibei Shi: Da shi wen hua you xian gong si, 2017.
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6
Xiuhui, Zhang, ed. Mei tian 5 fen zhong, che di gai bian ti zhi de chao qiang zu liao fa: Zhen dui 78 zhong chang jian bing zheng, lian ai zheng, bu yun zheng dou you zhi yu shi ji de zu bu an mo / Jinze Aisha zhu ; [fan yi Zhang Xiuhui]. Xinbei Shi: Da shu lin chu ban she, 2013.
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Ijūin, Kasumi. Yi tian yi shen zhan geng nian qi zi yu qing yun dong: 30 zhong ti gan xun lian huan jie geng nian qi fan ren de zheng zhuang, fang song ji rou geng nian qing! Xinbei Shi: Taiwan guang sha you sheng tu shu you xian gong si, 2014.
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