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Journal articles on the topic 'Lip function'

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Published: 2 June 2025

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Rayner, Colin R., M. L. Fogel, and M. F. Stranc. "Lip function." Plastic and Reconstructive Surgery 79, no. 4 (1987): 674. http://dx.doi.org/10.1097/00006534-198704000-00057.

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Bonilla, A., та J. C. Fariña. "Lip α Approximation on Closed Sets with Lip α Extension". Canadian Mathematical Bulletin 38, № 1 (1995): 23–33. http://dx.doi.org/10.4153/cmb-1995-004-3.

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AbstractLet F be a relatively closed subset of a domain G in the complex plane. Let f be a function that is the limit, in the Lip α norm on F, of functions which are holomorphic or meromorphic on G (0 < α < 1). We prove that, under the same conditions that give Lip α-approximation (0 < α < 1 ) on relatively closed subsets of G, it is possible to choose the approximating function m in such a way that f — m can be extended to a function belonging to lip

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Griffiths, Richard W. "Comparison of lip function." Plastic and Reconstructive Surgery 83, no. 1 (1989): 202. http://dx.doi.org/10.1097/00006534-198901000-00069.

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Jiménez-Vargas, A., J. M. Sepulcre, and M. Villegas-Vallecillos. "Biduality and density in Lipschitz function spaces." MATHEMATICA SCANDINAVICA 121, no. 1 (2017): 92. http://dx.doi.org/10.7146/math.scand.a-25987.

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For pointed compact metric spaces $(X,d)$, we address the biduality problem as to when the space of Lipschitz functions $\mathrm{Lip}_0 (X,d)$ is isometrically isomorphic to the bidual of the space of little Lipschitz functions $\mathrm{lip}_0 (X,d)$, and show that this is the case whenever the closed unit ball of $\mathrm{lip}_0 (X,d)$ is dense in the closed unit ball of $\mathrm{Lip}_0 (X,d)$ with respect to the topology of pointwise convergence. Then we apply our density criterion to prove in an alternative way the real version of a classical result which asserts that $\mathrm{Lip}_0 (X,d^\alpha )$ is isometrically isomorphic to $\mathrm{lip}_0 (X,d^\alpha )^{**}$ for any $\alpha \in (0,1)$.

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Mihas, Elena. "Interactional functions of lip funneling gestures." Gesture 16, no. 3 (2017): 432–79. http://dx.doi.org/10.1075/gest.00004.mih.

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Abstract Based on extensive ethnographic fieldwork in lowland Peru, this study examines interactional functions of Northern Kampa (Arawak) lip funneling gestures. The study has shown that lip funnels have two functions, spatial deictic and upgrading. Spatial deictic lip funnels orient the addressee to a referential target in acts of direct and deferred ostension and abstract pointing; they are accompanied with aligned gaze and coupled with a variety of lexical items (although they need not be). Spatial deictic lip funnels are intense, sometimes held for the duration of the entire utterance. The second function of lip funnels is to amplify the speaker’s claim to epistemic authority in upgraded responses. In the upgrading function, lip funnels are paired with a limited range of grammatical constructions (negative-interrogative, polar focus and exhaustive focus); the gesturer’s gaze is directed at the recipient, or eyes are shut. Nasalization of vowels is in complementary distribution with eye shutting. ‘Upgrading’ lip funnels are transitory facial actions, normally lasting a split second.

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Buczolich, Zoltán, Bruce Hanson, Balázs Maga, and Gáspár Vértesy. "Lipschitz one sets modulo sets of measure zero." Mathematica Slovaca 70, no. 3 (2020): 567–84. http://dx.doi.org/10.1515/ms-2017-0372.

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AbstractWe denote the local “little” and “big” Lipschitz functions of a function f : ℝ → ℝ by lip f and Lip f. In this paper we continue our research concerning the following question. Given a set E ⊂ ℝ is it possible to find a continuous function f such that lip f = 1E or Lip f = 1E?In giving some partial answers to this question uniform density type (UDT) and strong uniform density type (SUDT) sets play an important role.In this paper we show that modulo sets of zero Lebesgue measure any measurable set coincides with a Lip 1 set.On the other hand, we prove that there exists a measurable SUDT set E such that for any Gδ set E͠ satisfying ∣EΔE͠∣ = 0 the set E͠ does not have UDT. Combining these two results we obtain that there exist Lip 1 sets not having UDT, that is, the converse of one of our earlier results does not hold.

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Flores Genaro, Katia, Alceu Sergio Trindade, and Inge Elly Kiemle Trindade. "Electromyographic Analysis of Lip Muscle Function in Operated Cleft Subjects." Cleft Palate-Craniofacial Journal 31, no. 1 (1994): 56–60. http://dx.doi.org/10.1597/1545-1569_1994_031_0056_eaolmf_2.3.co_2.

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EMG activity of the upper lip was measured with bipolar surface electrodes during speech and nonspeech tasks In order to assess labial function in subjects with repaired clefts. Eighteen patients between 15 and 23 years of age with repaired unilateral cleft lip (Isolated or combined with repaired cleft palate) were compared to 24 matched noncleft subjects. Data analysis demonstrated that the amplitude of action potentials of the upper lip was significantly greater In the cleft group. We hypothesize that the enhanced activity of the repaired upper lip during function may contribute to the facial growth abnormalities usually seen In the cleft population.

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KATO, Rie, Takahiro FUNATSU, Tomomi SUGIYAMA, et al. "Study of Lip Function in Children with Cleft Lip and Palate;." Dental Medicine Research 31, no. 2 (2011): 113–22. http://dx.doi.org/10.7881/dentalmedres.31.113.

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Murotani, Yuki, Kodai Hatta, Toshihito Takahashi, et al. "Oral Functions Are Associated with Muscle Strength and Physical Performance in Old-Old Japanese." International Journal of Environmental Research and Public Health 18, no. 24 (2021): 13199. http://dx.doi.org/10.3390/ijerph182413199.

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Grip strength and walking speed are considered to be important indicators of physical frailty. However, no study has contemporaneously examined any association of multiple oral functions with grip strength and walking speed. The purpose of this study was to examine which oral functions are associated with muscle strength (grip strength), physical performance (walking speed) or both. The study participants were 511 community-dwelling people (254 men and 257 women) aged 77–81 years old. Six oral functions—oral wetness, occlusal force, tongue-lip motor function, tongue pressure, masticatory performance and swallowing function—were measured. Grip strength and walking speed were also measured. A partial correlation analysis, adjusted for gender, showed that occlusal force, tongue-lip motor function, masticatory performance and swallowing function were significantly associated with both grip strength and walking speed. In addition, tongue pressure was significantly associated with grip strength. A general linear model showed that tongue pressure and occlusal force were significantly associated with grip strength. Swallowing function and tongue-lip motor function were significantly associated with walking speed. It is suggested that there are different oral function measures for muscle strength and physical performance, and these oral function measures could be a useful proxy for physical frailty.

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Cahill, Louise M., Bruce E. Murdoch, Deborah G. Theodoros, Edward J. Triggs, Bruce G. Charles, and Amy A. Yao. "Effect of Oral Levodopa Treatment on Articulatory Function in Parkinson's Disease: Preliminary Results." Motor Control 2, no. 2 (1998): 161–72. http://dx.doi.org/10.1123/mcj.2.2.161.

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To quantify lip function in 16 subjects with Parkinson's disease, a computerized semiconductor lip pressure transducer system was used prior to subjects being administered oral levodopa and at approximately 0.5 hr, 1.5 hr, and 3.0 hr postmedication. Two blood samples were taken from each subject at varying times during the levodopa dosage interval, and the exact time and dosage of levodopa were noted. Lip function measurements were expressed as percentage changes from baseline and were plotted for each subject against time and levodopa concentrations to determine the effects of levodopa therapy on articulatory function. The results supported the effectiveness of levodopa therapy in improving lip function. In particular, lip pressures recorded during both speech and nonspeech tasks tended to improve after levodopa administration, the lip measures improving somewhat in parallel with the rise and fall of blood plasma levodopa concentrations. Evidence of a hysteresis effect was noted.

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Panthi, Sunny, Mohit Kamra, Amrit Khosla, Atulya Sharma, and Swati Kapoor. "Modified Complete Denture Prosthesis to Support Lip and Improve Speech in Completely Edentulous Patients with Neurological Problem—A Case Report." Dental Journal of Advance Studies 05, no. 03 (2017): 127–29. http://dx.doi.org/10.1055/s-0038-1672096.

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AbstractLip has an important role in esthetics and phonetics of an individual. Damage to marginal mandibular nerve leads to loss of motor function and muscle tone of the affected side of lip. Eventually, it leads to loss of both primary functions of lip. Various surgical approaches of treatment do exist, but the treatment time is long and results are often not satisfactory. Prosthetically, these patients can be managed with the help of lip plumber prosthesis. This case report presents simple and accurate method to restore the harmonious relation of the lip.

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Peled, Isaac J. "Aesthetics and Function in Lip Reconstruction." Aesthetic Plastic Surgery 23, no. 4 (1999): 275–78. http://dx.doi.org/10.1007/s002669900282.

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He, Qiong, and Hai Yun Xiong. "Complex Potentials for Plane Problem of Two-Dimensional Quasicrystals with a Lip-Shape Crack." Advanced Materials Research 1004-1005 (August 2014): 1415–18. http://dx.doi.org/10.4028/www.scientific.net/amr.1004-1005.1415.

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By introducing a conformal mapping and applying the complex variable function method, two potential functions are determined for plane problem of two-dimensional quasicrystals with a lip-shape crack. When the height of the lip-shape crack approaches to zero, the results can be reduced to the solutions of the Griffith crack.

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Trotman, Carroll-Ann, Ceib Phillips, Julian J. Faraway, and Kelly Ritter. "Association between Subjective and Objective Measures of Lip Form and Function: An Exploratory Analysis." Cleft Palate-Craniofacial Journal 40, no. 3 (2003): 241–48. http://dx.doi.org/10.1597/1545-1569_2003_040_0241_absaom_2.0.co_2.

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Objective In patients with cleft lip and palate, the aims of this study were to generate objective measures of different attributes of lip movement and to explore the utility of these objective measures by examining the association between examiners’ subjective assessments with the objective measures. Patients and Participants Thirteen patients with unilateral cleft lip and palate with varying degrees of cleft scar severity were selected. All patients had a previously repaired complete unilateral cleft lip and palate. Interventions Photographs and videotape recordings were made of the patients with cleft at rest and during smiling. Measurements of lip movement were obtained by means of a motion analysis system. Main Outcome Measures The study sought to obtain rankings of cleft scar severity and impairment on a 6-point Likert scale by a lay and professional panel and measurements of displacement, asymmetry, speed, and velocity of upper lip during smiling. Results Displacement was the most consistent and valid objective measurement. An objective analysis of the entire upper lip provided the most information. In general, there was a decrease in the objective measures of upper lip movement as examiners’ perceptions of facial appearance or disfigurement at rest and impairment during movement became worse. This relationship was stronger for the at-rest perceptions, implying that subjective assessments should be made with the face at rest. Conclusions Objective measures provided the promise for differentiation of the components of movement and should be used to supplement subjective evaluations of lip appearance at rest and during movement.

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Henkel, Kai-Olaf, Karsten Gundlach, and Basam Saka. "Incidence of Secondary Lip Surgeries as a Function of Cleft Type and Severity: One Center's Experience." Cleft Palate-Craniofacial Journal 35, no. 4 (1998): 310–12. http://dx.doi.org/10.1597/1545-1569_1998_035_0310_ioslsa_2.3.co_2.

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Objective This study was conducted to ascertain the frequency of surgeries typically required to adequately repair a cleft lip. Material All operations performed on patients with clefts of the lip (alveolus and palate) from 1968 to 1990 in the Rostock Cleft Center were evaluated. Methods Procedures were classified as primary labioplasties versus secondary revisions. Patients were also classified according to cleft type, the anatomical segment revised, and the reason for lip revision. Two indices were calculated. The revision index related the number of revisions to the number of primary labioplasties. The index of indication related the number of patients with revisions to the number of primary labioplasties. Results During the period of study, 712 primary labioplasties and 771 secondary revisions were performed. The overall revision index was 1.10. The index of indication varied from 0.28 for unilateral complete clefts of the lip to 0.67 for bilateral complete clefts of the lip. Revision of the lip was the most common secondary procedure, followed by nostril and columella revision, and revision of the oral vestibule. Conclusions The incidence of secondary surgery of the repaired cleft lip (index of indication) of about 35% is similar to previously reported data. However, the incidence varies with cleft type and is required more often with bilateral complete clefts of the lip.

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Maltsev, Alexey P., Ilya V. Chepkasov, Alexander G. Kvashnin, and Artem R. Oganov. "Ionic Conductivity of Lithium Phosphides." Crystals 13, no. 5 (2023): 756. http://dx.doi.org/10.3390/cryst13050756.

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We comprehensively study the ionic conductivity in lithium phosphides, promising materials for energy storage applications, by using a combination of first-principles computations and machine learning interatomic potentials. Using the quasiharminic approximation, we calculated convex hulls of the Li-P system at various temperatures and the temperature-composition phase diagram was obtained, delineating the stability regions of each phase. The ionic conductivity of stable (Li3P, LiP, Li3P7, Li3P11, LiP7) and metastable (Li4P3, Li5P4, LiP5) compounds was studied as a function of temperature. In some compounds we found have high ionic conductivity at room temperatures (10−3–10−2 S cm−1). Structures with the lowest ionic conductivity are LiP, Li3P11, and LiP7, in which diffusion is negligible in the whole temperature range 300–500 K. In Li3P, Li3P7, and Li4P3, LiP, there is the 3D diffusion of Li atoms, while in Li5P4 the 2D mechanism prevails, and in LiP5 and LiP7 the 1D mechanism was observed. This study may provide insights for the development of Li-P materials in lithium ion and lithium metal battery applications.

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Fuhrimann, S., A. Sch pbach, U. Th er, and B. Ingervall. "Natural lip function in wind instrument players." European Journal of Orthodontics 9, no. 1 (1987): 216–23. http://dx.doi.org/10.1093/ejo/9.1.216.

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Fuhrimann, S., A. Schupbach, U. Thuer, and B. Ingervall. "Natural lip function in wind instrument players." European Journal of Orthodontics 9, no. 3 (1987): 216–23. http://dx.doi.org/10.1093/ejo/9.3.216.

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Smithard, D., P. O'Neill, C. Park, and R. Wyatt. "Lip and Tongue Function Following Acute Stroke." Age and Ageing 26, suppl 3 (1997): P5. http://dx.doi.org/10.1093/ageing/26.suppl_3.p5-b.

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Kennedy, J. "Comparison of lip function: Surgery vs radiotherapy." Journal of Oral and Maxillofacial Surgery 46, no. 8 (1988): 714. http://dx.doi.org/10.1016/0278-2391(88)90128-0.

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Stranc, M. F., M. Fogel, and S. Dische. "Comparison of lip function: surgery vs radiotherapy." British Journal of Plastic Surgery 40, no. 6 (1987): 598–604. http://dx.doi.org/10.1016/0007-1226(87)90154-8.

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Hirano, Minoru, Shigejiro Kurita, and Hidetaka Matsuoka. "Vocal Function following Hemilaryngectomy." Annals of Otology, Rhinology & Laryngology 96, no. 5 (1987): 586–89. http://dx.doi.org/10.1177/000348948709600521.

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Vocal function following hemilaryngectomy was investigated in 54 cases in which a superiorly based sternohyoid muscle flap was used for glottic reconstruction. Four types of material were employed for covering the muscle flap: Hypopharyngeal mucosa, lip mucosa, thyroid perichondrium, and island cervical skin flap. The vocal function varied greatly from individual to individual; however, the following tendencies were observed in many cases: 1) the glottis did not close completely; 2) supraglottic structures (false fold, arytenoid region, and epiglottis) were hyperfunctional and vibrated instead of or together with the unaffected vocal fold; 3) vibrations of the laryngeal structures were irregular; 4) maximum phonation time was short; 5) mean airflow rate was high; 6) fundamental frequency and intensity ranges of phonation were limited; 7) the voice was rough, breathy, and/or strained; and 8) cases with poor vocal function were most frequent in the skin flap group and least frequent in the lip mucosa group.

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Singh, Uaday, and Shailesh Kumar Srivastava. "Trigonometric approximation of functions belonging to certain Lipschitz classes by C1 ⋅ T operator." Asian-European Journal of Mathematics 07, no. 04 (2014): 1450064. http://dx.doi.org/10.1142/s1793557114500648.

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The study of approximation properties of the periodic functions in Lp (p ≥ 1)-spaces, in general and in Lipschitz classes Lip α, Lip (α, p), Lip (ξ(t), p) and weighted Lipschitz class W(Lp, ω(t), β), in particular, through trigonometric Fourier series, although is an old problem and known as Fourier approximation in the existing literature, has been of a growing interests over the last four decades due to its application in filters and signals [E. Z. Psarakis and G. V. Moustakides, An L2-based method for the design of 1-D zero phase FIR digital filters, IEEE Trans. Circuits Systems I Fundam. Theory Appl., 44(7) (1997) 551–601]. The most common methods used for the determination of the degree of approximation of periodic functions are based on the minimization of the Lp-norm of f(x) - Tn(x), where Tn(x) is a trigonometric polynomial of degree n and called approximant of the function f. In this paper, we discuss the approximation properties of the periodic functions in the Lipschitz classes Lip α and W(Lp , ω(t), β), p ≥ 1 by a trigonometric polynomial generated by the product matrix means of the Fourier series associated with the function. The degree of approximation obtained in our theorems of this paper is free from p and sharper than earlier results.

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Hollenberg, Lloyd C. L. "The Didjeridu: Lip Motion and Low Frequency Harmonic Generation." Australian Journal of Physics 53, no. 6 (2000): 835. http://dx.doi.org/10.1071/ph00100.

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The dynamic acoustics of the Australian didjeridu are studied by separately considering transverse and longitudinal lip vibration models in the context of highly non-sinusoidal lip motion. Timedomain computer simulations are performed based on these lip models coupled to the input impedance function of a straight pipe. For the purposes of direct comparison, detailed results are reported here for lip motion leading to both sinusoidal lip opening area functions (characteristic of higher frequency brass instruments) and the more complex non-sinusoidal (approximately half-closed cycle) case characteristic of the didjeridu. Over a range of lip resonance frequencies, the sounding frequency for the transverse (longitudinal) model is found to be below (above) both the lip and fundamental pipe resonance frequencies, in qualitative agreement with linear theory for these value types. A striking difference is found between the two models when comparing the effect of significant lip closure in the non-sinusoidal cycle—the sounding frequency in the transverse case is raised by up to 10%, whilst essentially unaltered in the longitudinal model. The effect the lips sticking during the non-sinusoidal cycle was considered by increasing the damping force upon closure, and was found in both transverse and longitudinal models to weaken significantly the generation of harmonics in the sound.

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Oh, Tae-Suk, and Young Chul Kim. "A comprehensive review of surgical techniques in unilateral cleft lip repair." Archives of Craniofacial Surgery 24, no. 3 (2023): 91–104. http://dx.doi.org/10.7181/acfs.2023.00268.

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Unilateral cleft lip is a common congenital anomaly that affects the appearance and function of the upper lip and nose. Surgical repair of cleft lip aims to restore the normal anatomy and functionality of the affected structures. In recent years, several advances have been made in the field of cleft lip repair, including new surgical techniques and approaches. This comprehensive review discusses the surgical management of patients with unilateral cleft lip and palate and provides step-by-step instructions for the surgical procedures.

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Owens, Winston R., Diego M. Quirarte, Srinithya R. Gillipelli, Sarah A. Layon, John D. Bovill, and Lucas A. Dvoracek. "Lip Reconstruction." Seminars in Plastic Surgery 38, no. 04 (2024): 304–20. https://doi.org/10.1055/s-0044-1792107.

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AbstractLip reconstruction is challenging for plastic surgeons due to the unique functionality and aesthetic complexity of the lips within the lower third of the face. The etiology of lip defects varies from congenital to acquired causes of origin. The most common acquired cause of lip defects is resection of malignancy. Defects can present as various shapes and sizes and may affect any location on the lip. Each defect requires a full workup, and algorithms such as the rule of thirds, are commonly used to swiftly identify optimal reconstructive options. The goal of lip reconstruction is to ensure oral competence while restoring intricate, cutaneous landmarks. The approach to lip reconstruction makes use of many rungs of the reconstructive ladder. This article primarily focuses on repairing lip defects secondary to Mohs surgery; however, the reconstructive methods discussed are useful for lip defects of all causes. This article will review lip defect evaluation, reconstructive methods, common complications, and adjuvant therapies to ensure optimal lip function and cosmesis.

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Rathod, Rohit Narendra, and Bikash Kumar Bal. "Modalities of lip reconstruction in facial surgery- A literature review." IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain 9, no. 4 (2024): 117–22. http://dx.doi.org/10.18231/j.ijashnb.2023.025.

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The authors provide an overview of lip reconstruction of various defects. Lip reconstruction offers unique challenges to preserve not only lip function but also aesthetics. Lip reconstruction must take into consideration the three anatomical layers that comprise the lip and defects that involve the mucosa, the muscle, the skin or more than one layer will help determine the modality of repair. The authors offer an algorithm based on defect location, tissue involvement, and severity of defect to simplify an often complex decision-making process.

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Hadikhosuma, Jessica Novia, Bambang Wicaksono, and Rionaldo Dhiparedja. "COMPLETE UNILATERAL CLEFT LIP SURGERY USING MODIFIED ROTATION-ADVANCEMENT FLAP TO ENHANCE AESTHETIC APPEARANCE IN RSPAL DR. RAMELAN HOSPITAL: A CASE SERIES." Jurnal Rekonstruksi dan Estetik 9, no. 2 (2024): 100–110. https://doi.org/10.20473/jre.v9i2.59067.

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ABSTRACT Introduction: Unilateral cleft lip is a common congenital anomaly that impacts both the appearance and function of the upper lip and nose. Surgical cleft lip repair aims to return the affected structures to their normal anatomy and functionality. In recent years, several advances have been made in cleft lip repair, including new surgical techniques and approaches. In this current study, authors have adapted Millard's rotation-advancement flap technique and further modified it throughout his 14 years of experience. Case Presentation: This case series included 4 patients at RSPAL Dr Ramelan Hospital between September 2023 and February 2024, focusing only on complete unilateral cleft lip repair using the modified rotation-advancement flap. The surgery techniques and outcomes of the surgeries, including aesthetic improvements and functional outcomes, are discussed. This case series highlights the effectiveness of the modified techniques in achieving satisfactory results for patients with complete unilateral cleft lips, contributing to their overall well-being and quality of life. Conclusion: The modified rotation-advancement flap represents a valuable approach for complete unilateral cleft lip repair, providing satisfactory outcomes in aesthetics and function. Further research, long-term follow-up studies, and larger sample sizes are needed to validate its effectiveness and refine surgical techniques. Keywords: Cleft lip surgery, complete unilateral cleft lip, modified rotation-advancement flap.

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Sanniec, Kyle, Jourdan Carboy, and James Thornton. "Simplifying Lip Reconstruction: An Algorithmic Approach." Seminars in Plastic Surgery 32, no. 02 (2018): 069–74. http://dx.doi.org/10.1055/s-0038-1645882.

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AbstractThe authors provide an overview of lip reconstruction after Mohs surgery based on the senior author's practice. Lip reconstruction offers unique challenges to preserve not only lip function but also aesthetics. Lip reconstruction must take into consideration the three anatomical layers that comprise the lip and defects that involve the mucosa, the muscle, the skin or more than one layer will help determine the modality of repair. The authors offer an algorithm based on defect location, tissue involvement, and severity of defect to simplify an often complex decision-making process.

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Sato, Atsushi, Asumi Yokota, Yoshihiro Hayashi та ін. "C/EBPβ Isoforms Regulate Proliferation and Differentiation of Regenerating Hematopoietic Stem/Progenitor Cells". Blood 134, Supplement_1 (2019): 3713. http://dx.doi.org/10.1182/blood-2019-128026.

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Under stress or regenerative conditions, HSCs rapidly enter into cell cycle and are reprogrammed toward myeloid-biased hematopoiesis to meet the increasing demand of myeloid cells. We have previously shown that the transcription factor C/EBPβ plays critical roles at the level of HSPCs under stress conditions (Nat Immunol 2006, J Immunol 2012, Leukemia 2013 and Blood Adv 2019). However, underlying molecular mechanisms of action remain largely unknown. In this study, we have investigated the detailed function of C/EBPβ in regulation of HSPCs. We first evaluated the impact of C/EBPβ on the cell cycle status of LT-HSCs. To exclude the cell-extrinsic contribution of C/EBPβ, CD45.2+ BM cells from WT or Cebpb-/- mice were transplanted into lethally irradiated CD45.1+ WT mice, and these "BM-replaced" recipients were subjected to the following experiments. At steady state, the cell cycle statuses and the numbers of HSPCs did not significantly differ between the recipients of WT cells and those of Cebpb-/- cells. Immediately after 5-FU treatment, WT LT-HSCs entered the cell cycle, as revealed by the decreased percentage of cells in G0 phase and the increased percentage of cells in S/G2M phase. All these parameters of cell cycle acceleration were observed prior to the nadir of LT-HSCs induced by 5-FU and were significantly attenuated in Cebpb-/- LT-HSCs. Next, we assessed the numbers of LT-HSCs, KSL cells, and KL cells after 5-FU treatment. Following the nadir, the recovery of LT-HSCs preceded that of KSL and KL cells, suggesting the differentiation of LT-HSCs to KSL and KL cells. In the recipients of Cebpb-/- cells, the recovery of KSL and KL cells was delayed significantly. Collectively, cell cycle acceleration and subsequent differentiation of LT-HSCs under stress conditions were impaired in the absence of Cebpb. The Cebpb is a single exon gene, and three isoforms, namely, LAP*, LAP and LIP which lacks N-terminus, are translated from its unique mRNA. Due to their structural difference, they should have distinct functions. Here, we focused on expression and functions of these isoforms in regenerating HSPCs. To monitor expression of these isoforms in small numbers of HSCs, we devised a novel intracellular double staining method for flow cytometric analysis using two distinct anti-C/EBPβ antibodies. An antibody against the C-terminus of C/EBPβ recognized all three isoforms, while an antibody against the N-terminus of C/EBPβ only recognized LAP* and LAP. Thus, simultaneous staining with both antibodies should enable us to distinguish cells that dominantly expressed LIP (C-term+ N-term-) from those that expressed all three isoforms (C-term+ N-term+). Using this method, we monitored the expression patterns of these isoforms in LT-HSCs after 5-FU treatment. LT-HSCs initially became C-term single positive in response to 5-FU and subsequently changed to C- and N-term double positive, suggesting that LIP was upregulated prior to LAP/LAP* under stress conditions. These results suggest that phase-specific upregulation of LIP and LAP/LAP* is strongly associated with phase-specific functions of C/EBPβ in cell cycle activation and differentiation, respectively. Indeed, when EML cells, a mouse HSC line, were retrovirally transduced with LIP, the transduced cells were more proliferative and actively cycling than those transduced with the control vector, whereas proliferation and cell cycle were markedly suppressed in LAP*- and LAP-expressing EML cells. LIP-expressing cells remained undifferentiated, while LAP*- and LAP-expressing cells rapidly differentiated into CD11b+ myeloid cells and eventually stopped proliferating. In summary, our findings clearly suggest that sequential upregulation of C/EBPβ isoforms is critical for the regulation of HSCs under stress conditions. LIP amplifies the "reservoir" of HSPCs by accelerating the proliferation of HSCs during the early phase of regeneration, while LAP*/LAP induce their myeloid differentiation at a later phase. These findings should facilitate our understanding of the pathophysiology of infection, inflammation, and regenerating hematopoiesis in response to myeloablative chemotherapies or hematopoietic stem cell transplantation, all of which increase the hematopoietic demands. Disclosures Hirai: Kyowa Kirin: Research Funding.

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Alimdjanovich, Rizaev Jasur, and Tuksonboev Nurmukhammad Khamza Ugli. "CLINICAL AND ANATOMICAL FEATURES OF NASAL DEFORMITY IN PATIENTS WITH UNILATERAL CLEFT LIP AND PALATE AFTER CHEILOPLASTY." American Journal of Medical Sciences and Pharmaceutical Research 5, no. 8 (2023): 13–22. http://dx.doi.org/10.37547/tajmspr/volume05issue08-04.

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Over the past 50 years, significant progress has been made in the treatment of cleft lip and palate. Cleft lip and nasal deformity can permanently transform at an early age to a minimal or residual variation of the norm. To date, it is possible to achieve predictable results of surgical treatment of patients with unilateral cleft lip and nasal deformity, in which a normal aesthetic appearance and preservation of function are an important goal of treatment. However, patients may require multiple surgical procedures, from infancy to adulthood, to achieve the desired function and aesthetic quality.

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Santoso, Boedy Setya, and Citra Dwi Novastuti. "Upper Lip Reconstruction after Lip Cancer Wide Excision." Folia Medica Indonesiana 55, no. 2 (2021): 147. http://dx.doi.org/10.20473/fmi.v55i2.24631.

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Head and neck reconstruction serves two purposes, namely to restore function and aesthetics. The priority goals for lip reconstruction should be determined before surgery. In cases of large lip defects, maintaining the goal makes lip reconstruction difficult. This is a case report of a 66 year old man who came to ORL-HNS OPD, Dr. Soetomo Hospital, Surabaya with the main complaint of ulcers on the upper lip since one year ago accompanied by pain. A mass biopsy result on the right vestibule in Malang on October 11, 2016 showed adenosquamous cell carcinoma. The patient planned to have a wide excision and reconstruction of the lip defect. Wide excision and lip reconstruction was performed on 15 September 2016. Total resection of the upper lip was performed up to the vestibule of the nose. The results showed that squamous cell carcinoma was poorly differentiated. The evaluation after myocutaneous flap surgery was well combined, there were no signs of inflammation or infection. Patients can open their mouths, eat, drink and speak without complaint. The patient then received regular chemoradiotherapy two weeks after surgery.

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Chate, Rob AC. "The FR BCPPm: A novel, hybrid function regulator." Orthodontic Update 16, no. 1 (2023): 10–18. http://dx.doi.org/10.12968/ortu.2023.16.1.10.

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The design features of a novel, hybrid function regulator, the FR BCPPm, are presented to facilitate the construction of other such appliances that may be used in the treatment of juveniles with a prominent premaxilla associated with a bilateral cleft lip and palate and mandibular retrusion. As an essential prerequisite to facilitate secondary alveolar bone grafting, how it may be used and the results that can be achieved are documented in a single case. CPD/Clinical Relevance: To illustrate the design features of a novel function regulator in detail, which may be used to correct a prominent premaxilla in a patient with bilateral cleft lip and palate.

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Courbebaisse, Guy, Frederic Trunde, and Michel Jourlin. "WAVELET TRANSFORM AND LIP MODEL." Image Analysis & Stereology 21, no. 2 (2011): 121. http://dx.doi.org/10.5566/ias.v21.p121-125.

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The Fourier transform is well suited to the study of stationary functions. Yet, it is superseded by the Wavelet transform for the powerful characterizations of function features such as singularities. On the other hand, the LIP (Logarithmic Image Processing) model is a mathematical framework developed by Jourlin and Pinoli, dedicated to the representation and processing of gray tones images called hereafter logarithmic images. This mathematically well defined model, comprising a Fourier Transform "of its own", provides an effective tool for the representation of images obtained by transmitted light, such as microscope images. This paper presents a Wavelet transform within the LIP framework, with preservation of the classical Wavelet Transform properties. We show that the fast computation algorithm due to Mallat can be easily used. An application is given for the detection of crests.

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Nopoulos, Peg, Ian Choe, Stephanie Berg, Duane Van Demark, John Canady, and Lynn Richman. "Ventral Frontal Cortex Morphology in Adult Males with Isolated Orofacial Clefts: Relationship to Abnormalities in Social Function." Cleft Palate-Craniofacial Journal 42, no. 2 (2005): 138–44. http://dx.doi.org/10.1597/03-112.1.

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Objective In a previous magnetic resonance imaging (MRI) study, men with nonsyndromic clefts of the lip and/or palate (NSCLP) were found to have abnormalities in the structure of the frontal lobe of the brain. Moreover, many subjects with nonsyndromic clefts of the lip and/or palate have been described as being socially inhibited. A subregion of the frontal lobe, the ventral frontal cortex (VFC), has been shown to be related to social function. This study was designed to evaluate the morphology of the ventral frontal cortex in men with nonsyndromic clefts of the lip and/or palate, and the morphology's relationship to social function. Methods Subjects were 46 men with nonsyndromic clefts of the lip and/or palate and 46 sex matched controls. Social function was assessed using a standardized scale. The morphology of the ventral frontal cortex (composed of the orbitofrontal cortex [OFC] and the straight gyrus [SG]) was obtained from magnetic resonance imaging scans using the software BRAINS. Results After controlling for frontal lobe gray matter, the patient group had significant reductions in orbitofrontal cortex volume and area. The straight gyrus was not morphologically abnormal. Measures of orbitofrontal cortex morphology were significantly correlated to measures of social function—the greater the structural abnormality, the greater the social dysfunction. Conclusion Compared with healthy controls, subjects with nonsyndromic clefts of the lip and/or palate showed morphologic abnormalities in the cortical surface anatomy of a brain region known to govern social function, the orbitofrontal cortex. Moreover, the structural abnormality in this brain region was directly correlated with social function.

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Arcos Núñez, Nicole Andrea, Esteban Joel Gómez Quesada, Brian Steven López Nacimba, and Fuertes Paguay Mario Andrés. "Functional and aesthetic improvement through upper labial frenectomy.case report." Interamerican Journal of Health Sciences 4 (July 22, 2024): 96. http://dx.doi.org/10.59471/ijhsc202496.

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Long upper lip frenulums are bands of tissue that connect the upper lip to the gums and are longer than normal. This can cause functional and aesthetic difficulties. To correct this problem, an upper lip frenectomy can be performed, which involves removing or modifying the upper lip frenulum through a simple surgical procedure with quick recovery. A case is reported of a 21-year-old female patient who attended a consultation with complaints of difficulty in upper lip mobility, altered speech, and aesthetic dissatisfaction. After a thorough evaluation, it was determined that the patient had a long upper lip frenulum that limited lip mobility and affected oral function. An upper lip frenectomy was performed as a treatment, with the main purpose being the removal of the frenulum insertion fibers through a simple and minimally invasive surgical procedure.

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Perry, Bridget J., Brian D. Richburg, Bohdan Pomahac, Ericka M. Bueno, and Jordan R. Green. "The Effects of Lip-Closure Exercise on Lip Strength and Function Following Full Facial Transplantation: A Case Report." American Journal of Speech-Language Pathology 26, no. 2S (2017): 682–86. http://dx.doi.org/10.1044/2017_ajslp-16-0101.

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Purpose Facial transplantation is a relatively new option for individuals with severe facial disfigurements. Clinical case studies on existing patients indicate many instances of persistent facial motor impairment for facial expression, speech, and swallowing. These preliminary findings motivate additional research on the impact of lip-strengthening exercises following facial transplantation. Method In this study, we assessed the efficacy of an 8-week, biofeedback-driven, lip closure–strengthening exercise program in a single patient 1-year status post–full facial transplantation. Exercise was at 60% of peak strength. Outcome measures included instrumental measures of lip strength and mobility, clinical measures of speech, and patient-reported outcomes in feeding and facial expression. Results Results revealed improvements in labial strength, speed of lip movement, and range of motion during speech. A 3-point improvement in sentence speech intelligibility was also observed following strength-training exercise. The patient reported improvements in her ability to drink from a straw and communicate via facial expression. Conclusion These preliminary findings motivate additional research on the efficacy of lip-strengthening exercises following facial transplantation.

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Grigorescu, Ovidiu Dan, Marius Irimie, Nadinne Roman, et al. "Original Personalized Reconstruction Method for Certain Large Tumors of the Lower Lip (Not Including Oral Commissures)." Medicina 61, no. 1 (2024): 4. https://doi.org/10.3390/medicina61010004.

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Background/Objective: Surgical treatment of extensive tumors of the lower lip generates important defects in its structure and functions. Over time, a multitude of reconstruction options for these defects have been imagined. Unfortunately, the majority involve the use of both local and regional flaps, which either lack labial structure or disorganize the oral commissures as nodal oral function points. We set out to design a new reconstruction method that is not burdened by any of the above disadvantages, starting from the necessity to reconstruct large lower lip defects by exclusively using local and/or regional labial flaps belonging only to the healthy upper lip and the remaining structures of the lower lip after surgical tumor removal. In this way, the tissues involved in lower lip reconstruction will have a 100% labial structure and, supplementarily, the remaining oral commissures will not be damaged. Method: This new reconstruction method is based on the original association of WY-plasty to reduce the size of the large primary defect until it becomes congruent with the Abbe–Sabattini cross-lip flap. Results: Applied in a personalized manner, impressive results were obtained in several patients with lip tumors affecting about one-half of the lower lip length and in whom oncological surgical ablation produced defects in more than two-thirds of it. Conclusions: This new method is characterized by functional oral advantages, and can be applied in a personalized way to only certain categories of patients. Other disadvantages are characteristic and specific of Abbe–Sabattini cross-lip flap plasty.

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Safitri, Safitri, Sri Ayu Winarti, Windi Ikhtianingsih, and Nia Yuniarsih. "Optimalisasi Lip Balm Ekstrak Lidah Buaya (Aloe Vera L) Sebagai Pelembab Bibir." Syntax Idea 4, no. 7 (2022): 1160–65. http://dx.doi.org/10.46799/syntax-idea.v4i7.1919.

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Aloe vera has the potential to be used as a lip moisturizer because Aloe vera exudate contains lignin compounds that can help moisturize the skin of the lips. The use of lip balm on the lips has a function to maintain lip moisture and help treat chapped lips such as dry lips, chapped lips and dark lips. Lip balm or lip salve is a waxy substance that is applied to the lips from the mouth, the purpose is to moisturize the lips so they are not easily dry and cracked. Usually lip balm is used for lips that need protection, for example in conditions of low humidity or because the temperature is too cold, to prevent evaporation of water and epithelial cells of the lip mucosa. Lip balms often contain beeswax or carnauba wax, camphor, cetyl alcohol, lanolin, paraffin, petrolatum, and other ingredients. The purpose of this study was to determine how the stability of the preparation of Aloe vera extract lip balm. The results of this study showed that the stability of the lip balm preparation has good stability

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SJÖGREEN, L., A. LOHMANDER, and S. KILIARIDIS. "Exploring quantitative methods for evaluation of lip function." Journal of Oral Rehabilitation 38, no. 6 (2010): 410–22. http://dx.doi.org/10.1111/j.1365-2842.2010.02168.x.

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Lüsi, I., and G. Anbarjafari. "Mimicking speaker’s lip movement on a 3D head model using cosine function fitting." Bulletin of the Polish Academy of Sciences Technical Sciences 65, no. 5 (2017): 733–39. http://dx.doi.org/10.1515/bpasts-2017-0079.

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Abstract Real-time mimicking of human facial movement on a 3D head model is a challenge which has attracted attention of many researchers. In this research work we propose a new method for enhancing the capturing of the shape of lips. We present an automatic lip movement tracking method which employs a cosine function to interpolate between extracted lip features in order to make the detection more accurate. In order to test the proposed method, mimicking lip movements of a speaker on a 3D head model is studied. Microsoft Kinect II is used in order to capture videos and both RGB and depth information are used to locate the mouth of a speaker followed by fitting a cosine function in order to track the changes of the features extracted from the lips.

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Enfield, N. J. "‘Lip-pointing’." Gesture 1, no. 2 (2002): 185–211. http://dx.doi.org/10.1075/gest.1.2.06enf.

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‘Lip-pointing’ is a widespread but little-documented form of deictic gesture, which may involve not just protruding one or both lips, but also raising the head, sticking out the chin, lifting the eyebrows, among other things. This paper discusses form and function of lip-pointing with reference to a set of examples collected on video in Laos. There are various parameters with respect to which the conventional form of a lip-pointing gesture may vary. There is also a range of ways in which lip-pointing gestures can be coordinated with other kinds of deictic gesture such as various forms of hand pointing. The attested coordinating/sequencing possibilities can be related to specific functional properties of lip-pointing among Lao speakers, particularly in the context of other forms of deictic gesture, which have different functional properties. It is argued that the ‘vector’ of lip-pointing is in fact defined by gaze, and that the lip-pointing action itself (like other kinds of ‘pointing’ involving the head area) is a ‘gaze-switch’, i.e. it indicates that the speaker is now pointing out something with his or her gaze. Finally, I consider the position of lip-pointing in the broader deictic gesture system of Lao speakers, firstly as a ‘lower register’ form, and secondly as a form of deictic gesture which may contrast with forms of hand pointing.

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Meng, Ying Jie, Li Xin Bai, Wen Jun Liu, and Ming Wen Liu. "Extraction Algorithm of Lip Characteristic Parameters Based on Interpolation." Applied Mechanics and Materials 536-537 (April 2014): 235–40. http://dx.doi.org/10.4028/www.scientific.net/amm.536-537.235.

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In the research of identity recognition based on lip motion features, there are limitations for the existing algorithms of lip characteristic parameters extraction. This paper uses the strategy of lip static/dynamic geometric features fusion, designs the lip feature parameter extraction program based on interpolation, and implements the major aspects of processing algorithm of the program. The solution is based on the speaker's key six primitives spelling lip sequence image, firstly generates the lip key point coordinates in the image, then based on Lagrange interpolation obtains function curve coefficient of upper and lower lips' key points , lastly the two curve coefficients are combined to form lip motion feature information of human speaker's some specific sounds; Simulation results show that the extraction of characteristic parameters of the program not only have a high efficiency and availability, but also have the advantages of good storage.

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Aleksandrova, L. I. "COMPLEX TREATMENT EFFICIENCY, ANALYZED IN CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE, USING INTERNATIONAL CLASSIFICATION OF FUNCTIONING." Perm Medical Journal 35, no. 3 (2018): 74–78. http://dx.doi.org/10.17816/pmj35374-78.

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Aim. To determine the structure of functional disorders and their dynamic changes in children with congenital cleft lip and palate from the position of International Classification of Functioning. Materials and methods. The indices, included into International Classification of Functioning, were assessed in 77 children (age range 1 to 6 years) with congenital cleft lip and palate, who received a complex five-stage therapy. Results. Direct correlation between the type of cleft and the value of disorders in classification constituents “function” and “structure” was revealed. Thus, in patients with bilateral cleft lip and palate, disorders of functions reached 82 %, in children with one-sided cleft lip and palate - 45 %. In children of group I, more marked structural disorders were observed, forming from 24 to 96 %, in children of groups 2 and 3 - from 5 to 49 %. In children with bilateral cleft lip and palate, there were observed more marked abnormalities in the category “activity and participation” (25-95 %) compared to children of groups 2 and 3 (0-24 %). Conclusions. Application of International Classification of Functioning for children with congenital cleft lip and palate shows a wide range of the assessed functional disorders and the possibility of using it for dynamic analysis of efficiency and treatment.

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Oku, Saori, Kiyomi Iyota, Shinsuke Mizutani, et al. "The Association of Oral Function with Oral Health-Related Quality of Life in University Students: A Cross-Sectional Pilot Study." International Journal of Environmental Research and Public Health 17, no. 13 (2020): 4863. http://dx.doi.org/10.3390/ijerph17134863.

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The aim of this cross-sectional study was to investigate the association between oral function and oral health-related quality of life (OHRQoL) in healthy university students. Oral functions and OHRQoL (General Oral Health Assessment Index; GOHAI) were investigated in 58 healthy university students. Oral functions, such as tongue pressure, tongue-lip motor function, occlusal force, and masticatory function, were examined. The participants were divided into two groups based on low and high GOHAI scores. Information about oral health, dental caries treatment history, insomnia, and personality and lifestyle was obtained using a self-reported questionnaire. Oral mucosal wetness scores and tongue-lip motor functions (oral diadochokinesis /ka/) were significantly decreased in the low GOHAI score group compared to the high GOHAI score group (p = 0.001 and p = 0.017, respectively). In the logistic regression model, the GOHAI score was independently associated with the oral mucosal wetness score (odds ratio (OR) = 0.622; 95% confidence interval (CI), 0.411–0.941; p = 0.025) and oral diadochokinesis /ka/ (OR = 0.376; 95% CI, 0.170–0.832; p = 0.016). Our study demonstrated the presence of low oral function in university students and suggested its association to low OHRQoL in this population.

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Chinchai, Supaporn, Thanasak Kalaysak, Piyawan Jareontonyakorn, Natwipa Wanicharoen, and Kalyanee Makarabhirom. "Executive function performance in persons with non-syndromic cleft lip and palate." Journal of Associated Medical Sciences 57, no. 3 (2024): 36–42. http://dx.doi.org/10.12982/jams.2024.045.

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Background: Executive functions (EFs) are crucial cognitive functions that mature from birth to adolescence. They are vital for daily task execution and overall success and also influence language and communication development. Children with EFs deficits often experience delays in language and speech abilities. These impairments are particularly prevalent among individuals with cleft lip and palate. Consequently, speech and language pathologists must address these impairments through assessments and interventions. Despite this urgent need for action, there is a scarcity of research on executive function performance in this population in Thailand, prompting an investigation to address this issue. This study explores executive function performance in this population to enhance the quality of life for individuals with cleft lip and palate. Materials and methods: Using a survey-based approach, executive function performance was assessed in 5- to 15-year-old volunteer with non-syndromic cleft lip and palate attending the speech therapy camp provided by the Princess Sirindhorn IT Foundation Craniofacial Center at Chiang Mai University in April 2024. Parents completed the Behavior Rating Inventory of Executive Function (Parent form), with scores ≥65 indicating executive function difficulties. Results: The study involved 29 participants, 14 males (48.28%) and 15 females (51.72%), with a mean age of 8 years and 9 months. Average scores for executive function abilities in BRI, MI, and GEC were 52.21, 56.48, and 58.90, respectively. There are several participants with abnormal executive function in each age group, along with their average T-scores across different domains. Children aged 5, 6-8, and 9-11 have T-scores for executive function performances falling into problematic levels for 1, 2, and 5 individuals, respectively. Conclusion: Most of the sample group demonstrated executive function skills within the normal range. However, a certain number of individuals experienced issues with executive function. These findings offer guidance for speech and language pathologists and emphasize the importance of executive function in individuals with cleft palates.

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Zhang, Junhua, Rui Bao, Faisal Raza, et al. "Preparation and Evaluation of Onjisaponin B-Loaded Liposomes for Drug Delivery to Enhance Mitochondrial Function and Rescue Parkinson’s Disease by Activating Mitophagy." Journal of Clinical Pharmacy and Therapeutics 2023 (November 8, 2023): 1–13. http://dx.doi.org/10.1155/2023/1262109.

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Onjisaponin B (OB) is the main active ingredient of Radix Polygalae with various bioactivities. However, the protective effect of OB in Parkinson’s disease (PD) has not been fully studied. Liposomes are ideal nanocarriers for drugs targeting the brain. In this study, we investigated the therapeutic effect of OB-loaded liposomes (lip OB) on a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced mouse model of PD and 1-methyl-4-phenylpyridinium- (MPP+-) induced cell model of PD. Our results showed that lip OB significantly ameliorated MPTP-induced motor deficits and dopaminergic neuron loss in vivo and prevented MPP+-triggered cell viability reduction and apoptosis in vitro. Lip OB also improved mitochondrial dysfunction in PD models by driving PINK1/Parkin-mediated mitophagy. Furthermore, silencing PINK1 compromised the beneficial effects of lip OB on MPP+-treated PC12 cells. These findings suggested lip OB mitigates Parkinsonism in vivo and in vitro by enhancing mitochondrial dysfunction through the PINK1/Parkin pathway of mitophagy, which provides a new possibility for treating PD.

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Turan, Aydın. "Functional and Aesthetic Lower Lip Reconstruction With Depressor Anguli Oris Muscle Flap and Reverse Superior Labial Artery Flap." Annals of Plastic Surgery 93, no. 5 (2024): 589–96. http://dx.doi.org/10.1097/sap.0000000000004113.

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Background The lower lip is an important anatomical structure involved in daily activities such as eating, drinking, and speaking, as well as in facial expressions. Lower lip defects should be repaired to preserve lip function without disrupting the aesthetic harmony of the lips within the face. This goal is difficult for plastic surgeons because, for functional and aesthetic repair, it is necessary to replace the mucosa, muscle (especially contractile), and skin tissues present in the lip. Methods Subtotal lower lip repair was performed using an innervated depressor anguli oris muscle flap and a desepithelialized reverse superior labial artery flap in seven male patients with a mean age of 63 years. A depressor anguli oris muscle flap was used to repair the orbicularis oris muscle defect. The desepithelialized part of the reverse superior labial artery flap was used for mucosal defect repair, whereas the remaining part was used for skin defect repair. Patients were followed up for an average of 15 months. Patient lips, epithelialization, sensation, and sphincter function were clinically evaluated. Electromyography (EMG) was performed at 6 and 12 months to evaluate the function of the depressor anguli oris muscle flap. Results All the reverse superior labial artery flaps survived without any loss. Trapdoor deformity developed in the flaps of two patients. The desepithelialized parts of the flaps were completely epithelialized (covered with mucosa) by approximately 6th week. In the EMG controls of the patients at 6 months, the depressor anguli oris muscle was contractible. Sensation regained in the operated lip during the follow-up period. Conclusions The combination of an innervated depressor anguli oris muscle flap and a desepithelialized reverse superior labial artery flap is an important surgical option for the functional and aesthetic repair of subtotal lower lip defects.

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Suzuki, Toshihiro, Hidehiro Kishimoto, and Ryo Abe. "Initial IL7R signaling regulate the induction of effector CD8+ T cells and subsequent anti-tumor immune response in lymphopenic host (CCR3P.208)." Journal of Immunology 192, no. 1_Supplement (2014): 115.5. http://dx.doi.org/10.4049/jimmunol.192.supp.115.5.

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Abstract Induction of lymphopenia and adoptive transfer of T cells are followed by lymphopenia-induced proliferation (LIP), and generated a anti-tumor immune response. However, the distinct role of redundant IL7 in lymphopenic host and subsequent LIP of T cells for anti-tumor immune response has been unclear, since multiple mechanisms are involved in the anti-tumor immune response under lymphopenic conditions. To clarify the correlation between LIP and the anti-tumor effect, LIP was inhibited by IL7R blockade with anti-IL7Ra mAb at various stages, and the anti-tumor effect was assessed. When LIP was occurred, the growth of transplanted LLC expressing model antigen gp33, was markedly regressed. Using IL7R blockade with mAb at various stages, we found that IL7R signaling at the start of LIP is crucial for the anti-tumor immune response. Although some reports focused on the benefit of IL7 for the improvement of effector T cell function, later IL7R blockade did not arrest the expansion of CTLs, and anti-tumor effect was occurred. IFN-g production also depend on IL7R signaling during induction phase, but not later phase, and, the expression of co-inhibitory molecules, PD-1, on CTLs was unchanged in IL7R blockade hosts. In conclusion, our results demonstrated that initial IL7R signaling and subsequent LIP regulated the expansion of IL7Ra+ effector precursors mainly, but that the effector function of CTL precursors and migration into tumor did not require IL7R signaling.

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Yata, Tomomi, Norio Aoyama, Toshiya Fujii, et al. "Decreased Tongue–Lip Motor Function in Japanese Population with Low Taste Sensitivity: A Cross-Sectional Study." Journal of Clinical Medicine 13, no. 16 (2024): 4711. http://dx.doi.org/10.3390/jcm13164711.

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Background/Objectives: Taste disorders have a negative impact on meal enjoyment, which is essential for maintaining adequate nutrition and quality of life. Japan is a rapidly aging society with an increasing number of individuals with taste disorders. However, despite the increasing prevalence of taste disorders, the correlation between oral frailty and taste sensitivity remains largely unknown. The objective of this study was to assess the relationship between oral health status and taste sensitivity among the Japanese population. Methods: Participants were recruited from Kanagawa Dental University Hospital Medical–Dental Collaboration Center between 2018 and 2021. The exclusion criteria were severe systemic infections, pregnancy, or lactation. Clinical examinations, oral function assessments, and taste tests were conducted using tap water and 1% sweet, 0.3% salty, 0.03% umami, and 0.1% umami tastants. The relationships between oral function, systemic indicators, and taste sensitivity were statistically evaluated. Results: Of the 169 participants included in this cross-sectional study, 39.6% were male and 60.4% were female (median age, 68 years). Participants with low taste sensitivity showed a decline in tongue–lip motor function, independent of age, sex, or smoking status. A multiple logistic regression analysis conducted using two age categories—younger than 65 years and older than 65 years—revealed an association between tongue–lip motor function and taste sensitivity among participants younger than 65 years. Conclusions: Decreased taste sensitivity is associated with tongue–lip motor function. Therefore, the early maintenance of oral function and taste sensitivity may be beneficial for optimal tongue–lip motor function.

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